SHENZHEN HEPALINK PHARMACEUTICAL GROUP CO., LTD.
                   （深 圳 市 海 普 瑞 藥 業 集 團 股 份 有 限 公 司）

                                                      9989



 RESVERLOGIX




           Resverlogix Corp.   Resverlogix          RVX
         Apabetalone    –                           -2 (SGLT2)

(eGFR)                                          (HbA1c)                 BETonMACE 3
                      Resverlogix
                             Apabetalone                     SGLT2


         SGLT2                      (p=0.05)                                      Apabetalone
SGLT2                                                            eGFR
                        (p<0.001)                             Apabetalone    SGLT2
                        HbA1c




Apabetalone   SGLT2                                                         Resverlogix
                                               2040
                                                   MACE             Apabetalone      SGLT2
                                                                   CKD


    eGFR HbA1c
  BETonMACE                                                       CKD
           CKD
    Resverlogix Apabetalone         SGLT2


                                                1
       eGFR       CKD

                                         eGFR                                        CKD
                                                                                            CKD

        CKD                      700                                        CKD




       HbA1c

HbA1c                                           HbA1c                                         II
        (T2DM)                                                HbA1c
                     HbA1c               4.0%       5.6%                     HbA1c
5.7%    6.4%      HbA1c         6.5%                                                 T2DM
                                                                           T2DM
           HbA1c




SGLT2                                                                   T2DM
          HbA1c                                T2DM                                  HbA1c
       7.0%         SGLT2                HbA1c    7.0%
                  2013                                         FDA
T2DM
                   2024                                    250        Mordor Intelligence     2019
                                                             SGLT2
                    (ACS)         MACE

       RESVERLOGIX

Resverlogix          2000   8    17
                                  RVX                                      Resverlogix      38.50%


Resverlogix                                     Apabetalone (RVX-208)
BET                                       Apabetalone                             FDA




                                                2
BET                                                 Apabetalone      BET
            (BD2)         BET       Apabetalone   BD2




            RVX-208 (Apabetalone)
                                                             RVX-208 (Apabetalone)




2020   11   12




                                       3