T I G E R M E D 01 ConTenTs Tigermed Sustainability report LEADING CHANGE While the world is facing unprecedented changes in decades, changing to respond to change and welcoming change over responding. Tigermed proactively adapts to changes in regulations, customer needs and social patterns, and keeps innovating its own mindsets, technologies and operational models to lead industry development. Amidst complex changes, keeping a clear goal helps one stay on course. Tigermed stays true to the mission of "serving healthcare partners through innovation, advancing human health through excellence", and builds itself on the core values – honest & reliable, open & inclusive, collaborative & accountable, professional & innovative. Tigermed positions itself as a compliant business and works hand in hand with stakeholders towards sustainability. CoNtENts Driving innovation guiDing our PeoPle in the of CliniCal researCh 20 Quest for suCCess 38 02 LEADER'S SPEECH 52 KEY PERFORMANCE PoWeRInG GLoBAL MeDICAL InnoVATIon 22 ensURInG eMPLoYees' BAsIC RIGHTs AnD InTeResTs 40 04 ABOUT TIGERMED BeCoMInG A TRUsTeD CLInICAL ReseARCH PARTneR 25 ACTIVAInG TALenT AnD UnLeAsHInG PoTenTIAL 42 54 OUTLOOK UPHoLDInG QUALITY As THe CoRe oF THe BUsIness FosTeRInG An enGAGInG TIGeRMeD CULTURe 08 CORPORATE GOVERNANCE 56 HONG KONG STOCK EXCHANGE 28 44 ESG (ENVIRONMENTAL, SOCIAL AND 16 FEATURE: COUNTERMARCHING, Promoting inDustry Contributing to a GOVERNANCE) REPORTING GUIDE INDEX IN THE FIGHT AGAINST COVID-19 DeveloPment 30 shareD future 46 58 GRI (GLOBAL REPORTING INITIATIVE) ACCeLeRATInG THe DeVeLoPMenT oF HeALTH InDUsTRY LoCALLY 32 GReen TIGeRMeD: sTRenGTHenInG 48 INDEX enVIRonMenTAL MAnAGeMenT sHARInG IDeAs AnD ResoURCes WITH InDUsTRY PeeRs 34 CARInG TIGeRMeD: IMPRoVInG HeALTH 60 ABOUT THIS REPORT BUILDInG A sTRonG TALenT PooL FoR HIGH-QUALITY InDUsTRY 50 36 AWAReness AT CoMMUnITY LeVeL DeVeLoPMenT 02 01 LeADeR's sPeeCH Tigermed Sustainability report In the past 2019, Tigermed worked towards accelerating the 100% of top ten customers. such a success hinged upon the fast in work practice and are entrusted with key positions. Many launch of more innovative drugs for the benefit of patients. We pragmatic cooperation of our clinical research team. Through senior managers are veteran employees who have worked yielded fruitful results and ushered in a number of important industrial chain extension and regional service capacity with us for over ten years. We believe the development of the milestones. building, we provided customers with all-round solutions, Company and the growth of employees go hand in hand. timely response and effective countermeasures to address their During the year, the continued reform of China's drug and demands. We have witnessed the development of innovative drugs in medical device reviewing and approval brought us new China over the past 10 years. Drug innovation in China evolved opportunities and challenges. We concentrated our efforts on This year, we continued to expand our business landscape from one man's fight to a battle of thousands of innovators, innovative drugs and medical devices, and put more health in the Asia Pacific Region, europe and the United states, and in the meantime, the regulatory system keeps innovating to LEAD products to the market to drive the development of innovative drugs in China. We were behind a number of innovative products, such as BeiGene's Zanubrutinib, the first FDA- and further internationalized ourselves. We set up a joint venture with the Japanese company Accerise Inc. to provide international multi-center clinical trial services in Japan. in alignment with global practices. We have deeply felt the profound changes of the era, thus upgrading ourselves proactively to adapt to changes in regulations, customer needs, to INNovAtE approved anti-cancer drug developed in China, the first China- made biosimilar Rituximab Injection developed by Henlius, and the first China-made artificial heart "Yongrenxin". As of the first our first international multi-center clinical trial in singapore enrolled the first subject. We acquired 100% stake in Tigermed-BDM Inc. in U.s. and integrated its data statistics and social and cultural patterns. We keep innovating our own mindsets, technologies, service and operational models to respond to changes in the pharmaceutical industry and the quarter of 2020, we had helped cumulatively 36 Chinese Class and management resources into ours to adapt to global rapid growth of the Company. our robust growth is predicated I innovative drugs go on the market, rendering patients more competition. By the end of the reporting period, we have set up on the commitment to corporate mission and values, and on " We have deeply felt the profound changes of the era, thus upgrading ourselves proactively options. In 2019, our projects passed numerous inspections with outstanding performance, and won wide recognition from 17 overseas operation sites across 12 countries and regions in the Asia-Pacific region, north America and europe to fuel drug clinical trials by leveraging the wide-coverage service network. compliance management, which underpin our ability to lead the change. Looking forward to 2020, Tigermed will ride the trend of to adapt to changes in regulations, customer customers. We took pride in the trophies and letters of thanks 2019 was a year of milestones. We released the first social worldwide innovation and waves of continued reform in the needs, and social and cultural patterns. handed to us: Hua Medicine (shanghai) granted us the Handin- responsibility report to demonstrate our responsibilities, Chinese pharmaceutical industry, and continue to fulfill its Hand Progress Award; Hutchison MediPharma (shanghai) commitments and practices. our subsidiary, Frontage Holdings mission. We will adhere to the strategy of "Global excellence, We keep innovating our own mindsets, bestowed Hangzhou simo the excellent Team Award; and (1521 HK), launched a listing on the Hong Kong stock exchange China expertise", and align with high quality standards in the technologies, service and operational models 3DMed named Fantastic Bioimaging the Best Partner. We are to further globalize itself as a pharmaceutical CRo. Hangzhou R&D of CoVID-19 drugs. We will fuel the clinical development of chosen by more customers , and every year we remained Combak Hospital Co., Ltd. passed the GCP accreditation and more new drugs through efficient operation, and contribute to to respond to changes in the pharmaceutical obtained the Qualification Certificate of Drug Clinical Trial the health of humankind. i n d u st r y a n d t h e ra p i d g ro w t h o f t h e Institution. "small shield" APP developed by Hangzhou slanHealth Co., Ltd., our investee, was successfully licensed Company. " as a medical device – an Auxiliary Management software for Prevention Mother-to-Child Transmission of Viral Hepatitis B (VHB) by Zhejiang Medical Products Administration. Product quality is the lifeline of Tigermed, and the foundation of all our accomplishments. not long after our inception, we developed a quality management system in line with ICH-GCP Guideline to ensure project quality. We have fostered a quality culture to raise employees' quality awareness and gradually influence their work pattern and mindset. In the meantime, we incorporate the same quality standards into the supply chain to tighten quality management with suppliers. our priority on quality wins us lasting trust from and cooperation with more customers. Dedication of every employee has led to Tigermed's sustained and rapid growth. As talent is the most important asset of a CRo, we have developed management systems for talent selection, employment, training and retention, and customized management and training systems for professional and managerial personnel respectively. We are proud that our mid- Dr. Ye Xiaoping level and above managers benefit a lot from internal training. Ms. Cao Xiaochun Co-founder and Chairman Many employees have joined us right after graduation, grown Co-founder and General Manager 02 03 ABoUT TIGeRMeD Tigermed Sustainability report Regulatory Affairs Clinical Operations Biometrics solutions Integrated Technology Services Medical Devices / IVD Post-Marketing / Real World Evidence / Vaccine About tIGErmED business overview Tigermed builds an integrated and all-round platform that covers the whole industrial chain of clinical research, and spans across the overall development cycle of new drugs and medical Hangzhou Tigermed Consulting Co., Ltd. is committed to supporting clients in their clinical devices. In the pre-clinical stage, we offer bioanalysis, pharmaceutical research (including The Company was listed on development in the best possible way. As the leading clinical Contract Research organization Chemistry, Manufacturing and Control), bio-equivalency (Be) trials, and PK/PD services. For Phase the Growth enterprise Market (CRo) in China, Tigermed is dedicated to provide services for new drug research and development (GeM) of the shenzhen stock I to IV trials, our service covers project management and implementation, medical writing (such and other supporting services to global and Chinese pharmaceutical and biotechnology exchange (stock code: 300347. as clinical protocol and report), clinical monitoring, data management and statistical analysis, sZ) on August 17, 2012, and on companies. since our inception in 2004, Tigermed has always embraced new technologies and central imaging, pharmacovigilance, and site management organization (sMo). In addition, we the main board of the Hong partnerships to accelerate product development and generate the clinical evidence that our Kong stock exchange on August provide regulatory submission & approval service, medical translation, Good Manufacturing clients require to demonstrate real-world value. 7, 2020 (stock code: 3347.HK). Practice (GMP) qualification, training and auditing, and other integrated clinical services for medical devices from pre-clinical to post-launch stage. 04 05 ABoUT TIGeRMeD Tigermed Sustainability report honors Mission Serve healthcare partners through innovation, Advance human health through excellence Vision tigermed To be the recognized as the leading CRO Values The 11th China Healthcare summit of entrepreneurs, scientists, Honest & Reliable, Open & Inclusive, Collaborative & Accountable, Professional & Innovative The 12th China Pharmaceutical strategy Conference co- and Investors and Pharmaceutical Achievement exhibition of sponsored by China national Pharmaceutical Industry the 70th Anniversary of the Founding of the P.R.C. held by China Information Center and Taizhou Medical new & High-tech Pharmaceutical enterprises Association and China Medicinal Brand slogan Industrial Development Zone's Management Committee Biotech Association Global Excellence, China Expertise Trusted Clinical Research Organization partner innovative Chinese Cro of 2019 "top 10 Chinese listed Pharmaceutical Patient operational Quality Continuous Companies in investment value of 2019"; Centric excellence Priority innovation and "outstanding enterprises of the Pharmaceutical industry in Celebration of By collaborating We are committed to We strictly abide by the Looking forward "2020 China enterprise Credit Development Forum and closely with regulatory building a stable and ethics and regulations to the future, we the 11th Integrity Public Welfare Ceremony" held by China agencies, medical high-quality team in clinical research challenge ourselves enterprise Reform and Development society Association the 70th anniversary of the founding of the research institutes, with a strong sense and are committed to explore innovative and China Cooperative Trade enterprises Association hospitals, and our of responsibility. We to quality. To this solutions internally and P.r.C." global customers, we provide professional purpose, we provide externally. Through provide high-quality services and execute standardized, efficient, continuous optimization 2019 top 500 trustworthy listed medical solutions for efficiently through rapid and proven clinical trial unmet patient needs. response and internal services and we assure and breakthroughs, we enable our clients Companies in China coordination. product safety with a to market their scientific, rigorous, and products successfully professional attitude. worldwide and to Hangzhou Municipal Zhejiang Association for Corporate social ensure the sustainable Hua Medicine (shanghai) Ltd. Bureau of Commerce Responsibility development of our company. 1898 hand-in-hand Progress model hangzhou 2019 model Company in number of total customers (by the end of the reporting award Company in Corporate social responsibility Headquartered in Hangzhou, Tigermed runs 123 service outlets in China's mainland, Hong Kong period) and Taiwan.To drive the internationalization of pharmaceutical R&D, the Company has also service and trade in zhejiang Province opened overseas subsidiaries and offices in 10 countries and regions, including Korea, Japan, (for Practice Dimension) Malaysia, the United states, Romania and switzerland. 130+ number of global hangzhou simo fantastic bioimaging branches and service outlets (as of Q1 2020) The District economic Work Conference and Mobilization switzerlanD CanaDa Hutchison MediPharma (shanghai) Ltd. Meeting for Building the strongest Digital economy Zone romania held by Hangzhou High-Tech Zone (Binjiang) JaPan usa 36 excellent team award Korea number of Class I Chinese excellent young eagle enterprise innovative drugs successfully inDia launched (as of Q1 2020) Beijing Cancer Hospital malaysia singaPore 3DMed According to the report of 2019 beijing Cancer hospital best smo Frost & sullivan, Tigermed has become the largest clinical award for Clinical trials best Partner award CRo in China and among top ten in the world in terms of the australia operating revenue of 2019. frontage laboratories Life science Leader magazine 2019 Cro leadership awards 06 07 CoRPoRATe GoVeRnAnCe Tigermed Sustainability report CorporAtE general meeting of We hold general meetings of shareholders as required, and facilitate shareholders' participation so that they can fully exercise their rights. Certain proceedings are followed for the deliberation of each proposal to ensure all shareholders are GovErNANCE shareholders treated equally. shareholders' inquiries will be answered, and their suggestions and opinions be listened to. The discourse right of small and medium shareholders will be ensured. overview We comprehensively consider age, education Composition of the Fourth In accordance with the law, we have established the general meeting of shareholders, the Board ba c kg ro u n d , p ro fe s s i o n a l ex p e r i e n ce , s k i l l s , of Directors and the Board of supervisors, launched a system of independent directors, and set 6 board of and industry experience of directors to ensure Board of Directors by Age: up special committees under the Board. We have clearly defined the roles, powers, procedures number of general meetings of diversification of the Board. In April 2020, the and obligations of the general meeting, the Board of Directors, the Board of supervisors and the shareholders Directors Company held a re-election for the fourth Board 1 5 management in decision-making, implementation and supervision. As a result, we have leveraged Membership which comprises three non-independent Aged 40-49 Aged 50-59 directors and three independent directors. Among well according to the duties of authorities, decision-makers, business units, and supervisors, creating a governance mechanism of checks and balances. We act in strict accordance with the 15 them, 50% i.e.,three are female. Company Law of the People's Republic of China , the securities Law of the People's Republic of number of meetings of the Board of Directors China and regulations, as well as the internal control system including the Articles of Association , the Rules of Procedure of General Meeting , and the Procedural Rules of the Board of Directors to The Fourth Board of supervisors comprises two continuously improve the corporate governance system, and lay a solid foundation for regulated operations and sustainable development. 8 shareholder super visors and one employee supervisor, two of which are male and one is female. Composition of the Fourth Board of supervisors by Age: number of meetings of the Board of supervisors board of The shareholder and employee supervisors are During the reporting period, as our international development strategy was further implemented, supervisors respectively elected by the general meeting of 1 2 and the industrial chain continued to extend, we launched organizational reforms and built shareholders and the staff Representative Meeting. a "headquarters + business units" structure to empower the headquarters in creating value. The term of office of supervisors is 3 years. Aged 30-39 Aged 50-59 We have established six business units and functional headquarters to better accommodate development needs. President Office of Administration In accordance with the requirements of the relevant laws, regulations and the Finance Department Management system for Investor Relations , the Company designated the secretary Audit Committee to the Board as the person-in-charge for the management of investor relations, who Human Resources Department is responsible for coordinating investor relations, receiving visiting shareholders, Remuneration and Evaluation Committee Quality Assurance Department Internal Audit investor relationship answering enquires from investors and providing them with information already Department management disclosed by the Company. The Company responds to enquires from investors Strategic Development Data Resources and Compliance Department by means of phone calls, e-mails, interactive investor relations platform, investor Committee Legal Affairs Marketing and Business Development Department Department relations section in the corporate website, investor reception day, etc, which Nomination Committee enhances the exchange of information and promotes positive interactions with executive vice President Policy and Regulatory Affairs Department investors. Government Affairs Department board of Directors President / Ceo Administration Department The Company discloses its information in a true, accurate, complete and timely Chief operating officer Board Secretary Procurement Department manner in strict compliance with the relevant laws and regulations and the information Management system for Information Disclosure . During the reporting period, the Tigermed Investment Chief financial officer IT Department Disclosure Company issued a total of 4 periodic reports and 212 temporary announcements via the media outlets designated by the CsRC,namely The securities Times and the Innovation Center Preclinical and Generic Drug CnInFo website (www.cninfo.com.cn). Business Department Chief science officer Innovative Drugs Business Department Medical Devices Business Department In 2019 Biometrics Business Department 2.78 269.9168 Dividend per 10 shares Total cash dividend SMO Business Department (tax included) (RMB) (including share repurchase in 2019) (million RMB) New Industry Development Department 08 09 CoRPoRATe GoVeRnAnCe Tigermed Sustainability report Raising Employees' Anti- Launching Internal Audits corruption Awareness W e h a ve e sta b l i s h e d a n i n te r n a l s u p e r v i s i o n a n d Anti-corruption has been incorporated into our routine management system composed of both business units training. We cover all employees with anti-corruption and functional departments, such as risk supervision, training and assessment to raise their compliance compliance management, and audit departments. A multi- awareness. During the reporting period, we provided level supervision mechanism was also put in place to cover special anti-corruption training to the management, the headquarters, subsidiaries & branches and business including members of the Board, to enhance compliance units, to supervise and inspect the Company's financial awareness at the leadership level in clinical research and status, operation & management, salary distribution, and business operation. the performance of directors and senior executives on either a regular or irregular basis. The audit department should inspect and evaluate the audit supervision of the headquarters and holding and joint-stock companies, and submit internal audit reports to the Board of Directors. Protecting the Rights and Interests of Whistleblowers Protection of privacy: The personal information and Strengthening Supply Chain tips provided by the whistleblowers are kept strictly Compliance Management confidential. other units, departments and individuals have no right to access the information unless authorized. We integrate compliance requirements for suppliers Guard against retaliation: We have set up a mechanism into our anti-briber y and anti-corruption policies. to guard against retaliation against informants. When the C o o p e ra t i o n i s g r o u n d e d o n o b s e r v a n c e o f t h e Compliance management reports come from the inside, the Company will follow up aforementioned requirements. Suppliers should sign a to protect whistleblowers from workplace exclusion and third-party anti-bribery and anti-corruption statement retaliation. When the reports come from suppliers and in the bidding process, which specifies that suppliers partners, the Company will take measures to protect their shall not offer economic incentives in any form to Tigermed's steady development cannot be separated from its culture of compliance, integrity 100% rights and interests. once it is confirmed that the informant Tigermed employees. With these measures, we swear to and honesty. We strictly abide by national laws and regulations, international conventions and Coverage of staff anti-corruption has been retaliated, the Company will strictly deal with the strengthen compliance management from the very start business ethics, and constantly improve the internal supervision mechanism and risk control training personnel involved. of the supply chain. system. We boost integrity management to adapt to increasingly stringent supervision and regulations, and live up to compliance requirements for internationalization. in 2019 The column of "Compliance Concern" was opened up on the home page of our official website. According to the General Data Anti-corruption Protection Regulation (GDPR) Official website Informants shall fill in the form according to the guidance and may choose to report either anonymously or in real name. of the european Union, we have We conduct business with high ethical standards and strictly implement Policies of Anti-bribery improved soPs and management systems regarding legal affairs, Hotline Tip-off hotline for noncompliant conducts: 400-687-272-02 and Anti-corruption of Tigermed and Policies of Conflict of Interest. During the reporting period, IT and other departments we issued the notice on strengthening Compliance Management of Tigermed , and appointed involving personal information For anti-corruption and compliance: compliance.officer@tigermedgrp.com; Email addresses compliance and data security officers to strengthen compliance management across the of project personnel. We invited For data security: DPo@tigermedgrp.com european lawyers to carry out Clearing Company. As our presence in the global marketplace increases, we employ local legal consultants assessment and certification, Reporting The tips will go straight to our compliance officer / data protection officer, who will set up a and develop standard operating procedures (soP) to align operations to local policies and and organized training sessions working group for investigation, and deal with the reported matters according to investigation regulations. For example, we come up with Tigermed Physician Payments sunshine Act referring for all employees to enhance Channels results. Since the establishment of the reporting channels, the Company has not received any the awareness of personal to relevant regulations in the United states to meet compliance requirements. information protection and reports on compliance violation. compliance management. 10 11 CoRPoRATe GoVeRnAnCe Tigermed Sustainability report Risk management and control Csr management We have built a corporate governance structure consisting of the general meeting of shareholders, As of March 31, 2020 We work tirelessly to integrate social responsibility into corporate governance and operation, and the Board of Directors, the Board of supervisors and the management, and a risk control push for sustainability management and practices. We also continuously deepen the harmonious framework of the internal audit department, audit committee and business QA with a clear relationship with stakeholders to safeguard health for mankind, fulfill social responsibility, and division of duties, either of risk assessment or of risk management strategy. We have also set up risk assessment and control systems to standardize the management of business, finance, legal 19 achieve sustainable development. number of registered patents affairs, internal audit and information to improve security and guarantee sound and sustainable Leading organization and working mechanism development. IPR protection 377 We have set up a well-coordinated organizational structure to promote sustainability management. As a decision-maker, the Board of Directors is charged with the top-level design number of software copyrights of sustainable development affairs. The social Responsibility Department, as a coordinator We have put in place an intellectual property right management system. We manage intangible and supervisor, is responsible for promoting and monitoring implementation progress. The assets carefully, and strictly abide by provisions of our asset management system, scientific subordinate business units under the guidance of the headquarters perform CsR-related tasks as research management system, and personnel management system. And we actively reach out designated. to the national Copyright Administration to apply for and renew software copyrights and utility model patents. Formulate sustainable development strategies and policies Decision board of Directors Clinical trial ethics maker supervise and review achievements in sustainable development We strictly follow the Declaration of Helsinki and include it in staff training in the hope of 100% Implement resolutions of the Board of Directors on encouraging more employees to understand, support and participate in clinical research, and of Coverage of ethics training for sustainable development social responsibility accelerating the R&D of new drugs to contribute to public health. clinical trial practitioners Coordinator Communicate on and coordinate sustainable development Department issues Prepare sustainability reports Manage esG information on a daily basis subordinate business executives Fulfill esG management objectives units Provide timely feedback Tigermed's social Responsibility Management Mechanism Goals and objectives We continue to consolidate the foundation of social responsibility management. We focus on CsR management, responsible practices and sustainability branding to enhance the capacity for sustainable development and build competitiveness. Csr management Csr practices sustainability branding Improve the sustainable Fulfill social responsibility Through releasing social development mechanism and summarize model cases responsibility reports and put forth policies in line with our sustainable (sustainability reports), and systems to promote development strategy and we spread our sustainable normalized CsR key sustainability concerns development philosophy management of the industry and gradually create a brand image as a sustainable enterprise 12 13 CoRPoRATe GoVeRnAnCe Tigermed Sustainability report Sustainable relationship with stakeholders We conscientiously identify and manage the impacts of our decisions and operations. We prioritize material topics closely related to our own development, and regard the government, shareholders, customers, employees, partners, environment, and community as important players propelling our continued development. We are committed to answering for each and every stakeholder. We refer to Iso 26000 Guidance on social Responsibility, GRI sustainability Reporting standards issued by the Global sustainability standards Board, and environmental, social and Governance Reporting Guidelines of the Hong Kong stock exchange, to benchmark ourselves against outstanding practices in and outside China. Then, we proceed from the realities of the industry and our own conditions to identify material topic material topics for us and our stakeholders. We maintain active communication with all stakeholders. Through management Communication diversified mechanisms and channels, we listen to the voices and To fully grasp the expectations and needs of stakeholders, we with stakeholders concerns of all parties for mutual benefit and sustainable social conducted research and survey (with 454 valid questionnaires development. collected), and analyzed material topics from two dimensions, namely "relevance to stakeholders" and "relevance to Tigermed's sustainable development" for accurate results. stakeholders Demands Communication channels Tax payment according to law Inspection visits by leaders and competent departments Compliance operation Regular work summary and official document government and regulators Fair operation exchanges Creating jobs Daily policy implementation High Quality of products and services The general meeting of shareholders Protecting the rights and interests of subjects Compliant operations Information disclosure through regular reports and Raising customers' satisfaction Protecting the rights and interests of employees shareholders economic performance official website Tax payment according to law Employee training and development and investors Information transparency Investors' hotline Information transparency Risk management Employee welfare and care Work-life balance Business online platform irm.cninfo.com.cn of shenzhen stock Be Important to stakeholders Occupational health and safety performance R&D ethics Fair operation exchange Cultivating talents Responsible supply chain R&D innovation Product and service quality Customers, Customer visits Raising environment protection awareness Promoting industrial exchanges R&D ethics compliance Resource conservation including sponsors Daily communication by email and telephone and hospitals Waste management Environment management Reduce R&D costs Customer satisfaction surve Industry-university-research integration Improve R&D efficiency Participating in industrial investment Fair partnership Cooperation agreement Coping with climate change Partners Responsible procurement Industrial activities, such as exhibitions, and seminars Organizing public welfare activities Commitment to community health Protection of basic rights and interests Internal emails employees Personal growth and career development Internal publications Work-life balance Channels of soliciting demands low low Be Important to Tigermed's sustainable development High Communities and Health knowledge seminars Promoting community health the general public Public consultation and complaints Tigermed's Matrix of Material Topics 14 15 FeATURe: CoUnTeRMARCHInG, In THe FIGHT AGAInsT CoVID-19 Tigermed Sustainability report Rendering Immediate "this spring festival is meaningful. i'm heading out!" Support to "i'm a mom. i'm racing for life." Countermarchers on the ——Guo Tingting, project manager, after hearing the news, immediately informed her family and rushed to the hospital for help. Front Line ——Li Mei, after learning that the potential drug was about to go through Phase III clinical trial, picked up the phone and volunteered to help with the researcher just ten days after giving birth to her child. "Darling, wait for me back." A s the spring Festival of the year of 2020 approached, FEAturE CoVID-19 spread rapidly from Wuhan to the whole China. The "Count my dad in." pharmaceutical industry was racing against the clock to find ——Cao Lianjun, project manager, left potential effective antiviral drugs and rush to put them in "Please, drive me there asaP!" his months-old child and hurried off to clinical trials. Countermarching, the hospital to help researchers expedite ——Wan Yan, CRA based in Wuhan, trials. recommended her father as a Among them, one drug showed sound antiviral activity ——Gong Yunyan, CRA based in Beijing, volunteer to support transportation in the Fight Against against sARs coronavirus and MeRs coronavirus in early cell asked her sister to drive her to commute work during the Wuhan's lockdown. and animal experiments, and was regarded as a potential between the hospital and printing stores. therapeutic drug in the early stage of the outbreak. It was of With their efforts, our clinical trials got "my baby will take pride in me." COVID-19 great significance to find out its clinical effect and to verify its approved. efficacy and safety. An Mingru, an expectant mother at 36 At this critical moment, employees of Tigermed were informed weeks of pregnancy, still kept on working. that the China-Japan Friendship Hospital had already kicked off If one compares the fight against COVID-19 to a the study in Jinyintan Hospital of Wuhan. They volunteered to war without gunfire and smoke. step into the epicenter and threw themselves into the research. In addition to the clinical studies (for drugs, diagnostic Then those people who risk their lives to grapple reagents, and vaccines) at the onset of the pandemic, Tigermed Issued by the Party Committee of Binjiang District of Issued by Zhejiang Association for Corporate social Hangzhou City in recognition of the outstanding contribution Responsibility in recognition of Tigermed's impressive sense of with the lethal virus are not born heroes sent from donated money and supplies to the epicenter through of Tigermed during the fight against the pandemic. social responsibility and patriotism reflected in the donations. specialized agencies. In the case of shortage of materials, the the heaven. Company leveraged its own resources in the medical industry chain to purchase protective supplies for front-line medical "binjiang's Power in anti-CoviD-19 fight" 2020 outstanding Contribution award of zhejiang They are instead, ordinary people sacrificing their personnel. award enterprises in anti-CoviD-19 fight lives for the greater good. Tigermed chose to countermarch in the looming Letter of Thanks to the Family Members of Tigermed Staff shadow of the pandemic. In the battle against COVID-19, we deeply appreciate the efforts of your families. It's an honor of Tigermed to have such a group of excellent employees. We believe they will be able to complete the task smoothly and look forward to their safe return. Dr. Ye Xiaoping, Chairman of Tigermed on January 25, 2020, Dr. Ye Xiaoping, Chairman of Tigermed, and Ms. Ms. Cao Xiaochun, General Manager of Tigermed Cao Xiaochun, General Manager of Tigermed, along with all Tigermed's medical staff, donated RMB 2.08 million to support the fight against CoVID-19 in Wuhan. 16 17 FeATURe: CoUnTeRMARCHInG, In THe FIGHT AGAInsT CoVID-19 Tigermed Sustainability report Delivering High-quality Safeguarding Employees' Service as Always Health Wholeheartedly At 10:00 on January 23, 2020, Wuhan was locked down, and the "saving others is saving oneself." fast-running city was put on hold. Considering the pandemic and the unique nature of clinical trials, we However, our responsibility towards the sponsors and patients As a company specialized in medical pay high attention to the health and safety of employees. never ends. and health services, we stay true to the After informed of the outbreak before the spring Festival, The Wuhan team did a We established the emergency response team, worked online, supported mission of "serving healthcare partners functional teams, provided one-on-one services, initiated employee marvelous job for the recent Tigermed immediately established an emergency response assistance program (eAP), popularized protection knowledge, and sent through innovation, advancing human team for epidemic prevention and control. We launched our regards via the Labor Union… health through excellence". There are projects. Hope they and their the business continuity plan (BCP), and made detailed arrangements for research projects with sponsors to minimize our care for employees permeate the slightest matters. still cascades of difficulties in beating families are all fine. the impact of the pandemic. The pandemic tests the resilience of all enterprises. Despite the year- COVID-19. Therefore, we are pressing After learning Wuhan's lockdown, our project team members in Wuhan took immediate actions. They entered the research on-year decrease in business volume, we insist on no salary cuts and no ahead with clinical trials of therapeutic layoffs to reassure our staff, and do our best to maintain social stability. center after obtaining permission to transfer project data drugs worldwide to secure the final urgently and keep the test drugs properly. — Tigermed delivered products on time despite the pandemic, and was highly praised by our American As of the date of this report, there was not a single case of infection or victory of the battle, and contribute to To minimize the impact of the pandemic on clinical trials and client. suspected infection in Tigermed. public health. ensure the health and safety of subjects, CRAs and project managers, we introduced various solutions, such as online tigermed timeline of fight against CoviD-19 follow-up, online monitoring, and mailing samples and drugs, to ensure uninterrupted clinical operations and medication In response to the government's appeal, supply to the subjects. Issued a warning Transferred clinical we extended the holiday, postponed work company-wide to materials and drugs resumption and rolled out emergency response stay vigilant about during Wuhan's plans for business operation. The functional the epidemic. lockdown. departments introduced home office measures. January 20 January 23 February 2 January 21 January 25 February 3 Set up an emergency Donated RMB 2.08 Tigermed staff arrived at Jinyintan response team headed million to the Red Hospital and officially joined the by the President. Cross Society of China clinical trials. Zhejiang Branch. Issued Tigermed's Project members for COVID-19 Requirements on COVID-19 Tigermed and potential drug clinical trial Prevention and Control, Hangzhou Simo were in Wuhan returned back to specifying protection among the first batch of Completed the Hangzhou and Changsha and measures after business enterprises approved to first subject went on to a 14-day quarantine. resumption. resume work. administration. March 28 February 12 February 10 February 6 April 15 March 20 February11 February 7 All project members Successfully Donated PPEs such as Established Tigermed COVID-19 for COVID-19 potential launched Tigermed protective gowns, face Prevention and Control Team drug clinical trial in Annual Conference masks and gloves. specifically for clinical trials project Wuhan returned home. online. members in Wuhan. 18 19 Tigermed Sustainability report DrIvING INNovAtIoN poWErING GLobAL mEDICAL oF CLINICAL INNovAtIoN rEsEArCH Our Actions: Provide clinical trial services and bring new and effective drugs to patients bEComING A Promote innovation and marketization of pharmaceutical trustED CLINICAL products rEsEArCH pArtNEr expand clinical research business in Asia Pacific, north America and europe Protect the basic rights and interests of subjects strengthen quality management and integrate quality control into the whole supply chain Innovation is in the genes of Tigermed. The Company takes innovation as the key to harness changes in science and technology, in domestic and foreign pharmaceutical policies, and in customer demand. We upHoLDING QuALItY embrace innovation in technology, management and As tHE CorE oF tHE service to speed up corporate development, facilitate global pharmaceutical R&D, and safeguard the health of busINEss mankind. DRIVING INNOVATION OF CLINICAL RESEARCH Tigermed Sustainability report As of Q1 2020 poWErING GLobAL facilitated the marketing of the first indigenous anti-cancer Drug in the us Case once, it was taken for granted that effective anti-cancer drugs are mEDICAL 319 number of clinical research only developed by foreign companies. only after years of marketing overseas can these drugs finally enter China, depriving many INNovAtIoN projects of Class I Chinese patients of the best timing for treatment. In november 2019, the U.s. innovative drugs Tigermed participated in Food and Drug Administration (FDA) approved Zanubrutinib, a novel anti-cancer drug independently developed by Chinese biomedical enterprise BeiGene. Zanubrutinib thus became the first China- Under the policy guidance of the national pharmaceutical regulators, China's pharmaceutical industry has ushered in an era of boosting innovative drug R&D rather than confining itself to 36 developed anti-cancer drug approved by the FDA. Hangzhou simo provided sMo services throughout the clinical research process, generic drug production. It is now more actively engaged in global pharmaceutical innovation. number of Class I Chinese innovative drugs gained approval while Frontage Laboratories manufactured the experimental drug The development and application of innovative technologies such as big data and cloud to market with the support of and conducted heart safety clinical studies for Phase I trial. computing also empower the digital transformation of the CRo industry. Tigermed Powering Drug innovation, bringing Driving the "go global" of China's Patients new hope innovative Drugs China is now vigorously promoting the R&D of new drugs. It is committed to launching more In 2019 In 2019 In the wave of the globalization of pharmaceutical R&D, China became a member of the innovative drugs to the market to endow patients with more options. since its inception in 2004, International Conference on Harmonization (ICH) in 2017 and has aligned with global standards Tigermed has developed a sound pharmaceutical R&D service system that provides integrated for more global cooperation. To accommodate the growing demands for overseas R&D projects, and comprehensive clinical trial solutions for innovative drug R&D. 124 116 we actively plan our overseas business layout, and extend our businesses step by step to Asia R&D investment (million RMB) number of updated and Pacific, europe and the United states to boost our international competitiveness and bring improved soPs for supporting China's innovative drugs to the international arena. Tigermed focuses on clinical global project cooperation trial operation services for Tigermed provides other innovative drugs, generic drugs and medical devices, as well Clinical-related important services in the drug development process, 4.43% Participating in Riding the trend of globalized pharmaceutical R&D, we actively carry out Clinical trial R&D investment to operating as complementary services services and including data management revenue international projects multicenter trials worldwide. directly associated with solutions and statistical analysis, site clinical trial operations such laboratory management and patient as medical writing, translation services recruitment, medical imaging and registration services and pharmacovigilance services. as well as laboratory services. 7 Building strategic We join hands with overseas pharmaceutical enterprises and laboratories services for Pharmaceutical Innovation Among the 13 Class I drugs partnership to promote innovation and research. approved in China, 7 were developed with the assistance of Contributed to the approval of the first China-made artificial heart "yongrenxin", Tigermed or its subsidiaries. Case creating a medical miracle to regain a new life by new heart Joining hands with We communicate with overseas pharmaceutical organizations and learn Patients with heart failure and in need of heart transplantation overseas organizations from their best practices to narrow the gap. are often plagued by problems such as the lack of donors and the necessity of long-term anti-rejection and anti-infection treatments. The artificial heart has brought new hope for such patients. To the first subject successfully enrolled in singapore for international multi- Case break the monopoly of developed countries in the artificial heart Center trials technology and better address the needs of domestic patients, artificial heart "Yongrenxin" developed by Chongqing Yongrenxin In July 2019, Jiangsu Alpha Biopharma Technology's study of the new generation of oral small- Medical Devices was approved to be launched in the market in molecule reversible epidermal growth factor receptor (eGFR) tyrosine kinase inhibitor (TKI) - August 2019. Tigermed provided clinical research and technical AZD3759 successfully enrolled the first subject for a Phase II/III international multi-center trials services throughout the product's R&D. "Yongrenxin" fills the and finished administration in singapore. For Tigermed, this is the first international multicenter technical gap in the field of artificial heart in China. The innovative trial project and the first subject enrollment in singapore, which sets a shining example for product will rekindle the hope of patients for life. following research and development in southeast Asian countries. 22 23 DRIVING INNOVATION OF CLINICAL RESEARCH Tigermed Sustainability report teddy Clinical research laboratory established strategic Partnership with mlm Case (european) To better adapt to the trend of international multi-center clinical trial cooperation and meet the needs of global customers, Teddy Laboratory has formally established strategic partnership with MLM, a european based medical lab. Both sides will carry out extensive cooperation in international multi-center trials and one-stop laboratory services. Jiaxing Clinflash officially recognized as a member of CDisC to Deliver high- Case Quality service As an active advocate of the globalization of clinical trials, Jiaxing Clinflash was recognized as a gold member of CDIsC in May 2019. CDIsC is a global open non-profit organization (nPo) of whole disciplines. It aims to integrate best practices in the industry and establish unified standards for clinical R&D, to support the electronic acquisition, exchange, submission, and archiving of clinical and preclinical data. Through CDIsC's platform, Jiaxing Clinflash will continue to improve its system and service quality, meet CDIsC standards, and enhance the efficiency and benefits of pharmaceutical enterprises. ushering in organizational reforms in the bEComING A Digital age trustED CLINICAL The digital reform in the medical industry has been unveiled and accelerated by CoVID-19. We rEsEArCH pArtNEr embrace the changes by integrating innovative technologies into our strategy and decision- making. We formulate prudent digital upgrade plans to keep up with the fast-pace industrial Tigermed's popularity among customers hinges on the hard-working and pragmatic clinical transformation, and shoulder due responsibility for customers and patients. research team. We tirelessly extend the industrial chain and build regional service capacity to provide comprehensive and timely solutions, and strive to become a reliable clinical research partner for sponsors, clinical trial centers / researchers, and subjects. We appoint Chief Innovation officer (CIo) for the first time. Through reasonable data Business data use, we gradually build a digital management platform and an office collaboration collection platform to improve the transparency and efficiency of business operation, and lay a solid technical foundation for international collaboration. The sense of mission is deeply embedded in the mind of Tigermed Digital business We combine traditional business scenarios with digital technologies to facilitate the employees. We feel proud when the product we processed is marketed scenarios innovation, development and application of drugs. and benefiting patients. The recognition of customers is our perpetual source of motivation. We set up an innovation center to enhance the awareness of all staff at all levels, and tap Digital culture ——Ms. Cao Xiaochun, General Manager of Tigermed into the potential of each employee for innovation. 24 25 DRIVING INNOVATION OF CLINICAL RESEARCH Tigermed Sustainability report Continuously upgrading service Capacity To improve the efficiency of clinical trials, we build stronger professional service capacity to improve customer experience and protect the rights and interests of subjects. We strictly 100% guarantee the security of clinical trials and research data to safeguard the privacy of all parties. Annual retention rate of top ten customers Improve the ability of Protect the rights and Safeguard information on-site service interests of subjects security We set up a clinical trial center We sign the Informed We formulate information management organization Consent Form with subjects security policies and specify (Hangzhou simo) to assist beforehand to protect their the responsibilities and research institutions and right to be informed. And we requirements of confidentiality, researchers in clinical trial provide sponsors and research as well as the processing management. We have also institutions with patient procedures and transfer developed standard operating health training and academic requirements of personal data. procedures (soP) for seminars to protect the safety, We organize regular trainings Hangzhou simo to standardize welfare and rights of subjects. for all employees to enhance management and improve the By the first quarter of 2020, their awareness of data and quality and progress of clinical we had recruited over 7,100 information security. During the trials. As of the first quarter subjects. reporting period, there was no of 2020, Hangzhou simo had major information leakage or provided professional services data/agreement loss. in 956 sites across 106 cities. In september 2019, Hutchison MediPharma (shanghai) awarded top-performing suppliers for the first time, and Hangzhou simo won excellent voice from a CrC: Charging forward with the hope for life Case Team Award. establishing Complaint handling Tigermed is home to teams of hardworking frontline staff in clinical trials, whose daily routine is full of hustle and bustle. These people choose to march forward with the hope of marketing more mechanism new drugs for public use. "When will Patient 02 be here and has he made an Patient A failed to store appointment?" "The data for the interim analysis must be urine samples from this ready by next Wednesday." "The first PK blood sample of According to the satisfaction As a service-oriented enterprise, customer satisfaction is our goal. We have built a comprehensive morning as required; subject 1001 was hemolyzed just now. Do we need to give survey results in 2019 (10 customer feedback mechanism which allows us to understand customer demand, timely solve Patient B failed to additional explanation?" points in total) problems, and improve customer satisfaction through visits, telephone calls, survey and other complete CT examination means of communication. as scheduled; Patient Receive complaint As a clinical research coordinator (CRC), he/ she often says the following: And he/she often must face such incidents: C refused to return for safety follow-up. 9 Average score of PM satisfaction of sponsors / CRo Product Manager analyzes the complaint and forwards the message to relevant As a CRC, one may thus feel "I am a CRC, a bridge connecting doctors fighting for lives departments / Person in charge discouraged, but always and patients struggling to survive. To let patients access the holds on to this belief: latest treatment, I will not give up." 9.7 Product Manager / Responsible departments / Person in charge handles the Average score of researchers' satisfaction of CRC complaint (investigation, solutions, feedback, follow-up) After years of arduous work, the new drugs are finally put on the market. once again, in the battle between life and death, our clinical research team seizes the final victory. Post-solution survey over the years, I have grown from a novice to a veteran with the memories of dozens of patients engraved on my mind. There were hard times when mounting difficulties blocked our way; and Customer Complaint Handling Mechanism there were good times when the new drugs we worked on finally hit the market. eventually, the good trumped the bad. Marketing a new drug, for doctors, subjects, and CRCs alike means hope The Company keeps detailed records of customer complaints and divides them into four for survival and for life. categories, namely major (key issues), moderate (serious issues), minor (general issues) and invalid complaints for efficient management. In 2019, we received 17 complaints from customers ——An anonymous CRC and handled all effectively. 26 27 DRIVING INNOVATION OF CLINICAL RESEARCH Tigermed Sustainability report upHoLDING QuALItY As tHE Cultivating a Culture of Quality High-quality clinical research results cannot be guaranteed without a powerful culture of CorE oF tHE busINEss In 2019 quality. We focus on cultivating the quality awareness of employees during production and operation. Through orientation special training and regular trainings, we gradually change the way employees work and think, improve their awareness and make sure they understand and Drug quality concerns life and death. only by putting quality first can Tigermed gain a foothold 4 shoulder due responsibility. in the market, win more trust and sustain long-term cooperation. We continue to optimize the number of meetings on the quality management system held the first annual Quality management meeting to improve Quality awareness quality management system, create a quality culture with full participation of staff, integrate Case of the leadership quality control into the supply chain, and work with suppliers to ensure quality throughout the clinical research process. 1 In september 2019, Tigermed held the first annual quality management meeting in shanghai. The meeting welcomed 72 senior managers, 66 of which were heads of departments of the number of annual meeting on quality management headquarters and subsidiaries in China and 6 were from overseas institutions. The meeting, Continuously optimizing the Quality focusing on three themes: quality management, annual quality management activities and annual quality management audit reports, introduced the Company's annual quality management system management progress to the senior managers to consolidate the quality awareness of the In 2019 management and clinical teams from top to bottom, and create a quality-oriented corporate culture. We build a quality control system composed of the Quality Management Committee, Quality Assurance Department and Internal Audit Department, and constantly upgrade the system 13 number of projects passing by adopting the PDCA (Plan-Do-Check-Action) approach. In 2019, we integrated the soPs of inspection by nMPA domestic and foreign subsidiaries to build a unified quality management system, and improved the current processes in line with the Us and european regulations and the international strategy of Tigermed to better adapt to global development. 15 We formulated regulations and soPs such as Measures of Handling non-Compliance , and Received 15 audits of both domestic and overseas customers Corrective Action and Preventative Action to deal with major or serious quality incidents. our with no major issues found, and Quality Assurance Department will investigate the incidents at once, implement handling the reception and follow-up work measures, formulate corrective and preventive measures, and optimize the process according to were highly recognized by our integrating Quality Control into the customers. the PDCA principle to control risks and prevent the recurrence of similar problems. In 2019 supply Chain To control quality throughout the clinical research process, we incorporate supplier management 1604 into the soPs, and formulate specific management procedures for suppliers engaged in clinical number of suppliers trials with key performance indicators. In this way, we aim to further integrate quality control into the supply chain, and work with suppliers to strengthen quality management. 1028 We have formulated the supplier Management system to clarify the responsibilities and approval Strict supplier management Domestic suppliers authority of buying requisition, approval, purchase, acceptance, warehousing, payment, and inventory. We select suppliers based on principles like fairness and justice, full competition, integrity and self-discipline, and evaluate candidates from multiple dimensions to reduce economic, social and environmental risks threatening product quality and business ethics. 576 overseas suppliers We include supplier audit into the annual audit plan, and examine the quality performance of suppliers involved in clinical trials on a regular basis. We carry out on-the-spot on-cause audit of Supplier 8 quality incidents, and understand the whole operation process from personnel qualification and audit training to the establishment and improvement of the quality system through communication, to number of supplier audits help suppliers identify defects and enhance their quality management system. completed 28 29 Tigermed Sustainability report promotING INDustrY ACCELErAtING tHE DEvELopmENt DEvELopmENt oF HEALtH INDustrY LoCALLY Our Actions: Fuel the development of regional healthcare industry establish platforms for industry exchange and cooperation sHArING IDEAs AND Cultivate talents for the industry rEsourCEs WItH empower sMes INDustrY pEErs As a leading clinical CRO in China, Tigermed leverages its experience, resources and expertise to build a sound and enabling healthcare ecosystem together with industry peers, contributing to health for all. buILDING A stroNG tALENt pooL For HIGH-QuALItY INDustrY DEvELopmENt Promoting industry develoPment Tigermed Sustainability report assisted in Developing national biomedical industry base in Pingshan District, Case shenzhen The biomedical industry is developing rapidly in the Guangdong-Hong Kong-Macau Greater Bay Area, one of the most open and economically vigorous regions in China. Tigermed and shenzhen ACCELErAtING tHE Pingshan District People's Government have entered into cooperation to build an integrated service platform for clinical research. Building on Tigermed's expertise in the clinical research of DEvELopmENt oF HEALtH drugs and medical devices as well as the solid foundation for developing the biomedical industry in Pingshan District, we make full use of local preferential policies and favorable business environment to empower more biomedical innovation companies in the area, and to make it a INDustrY LoCALLY highland for biomedical innovation. Rising health awareness has led to increasing public demands for high-quality healthcare. Tigermed seizes the opportunity to assist in the reform of local healthcare industry and capitalizes on the clinical research expertise and best practices it has built up over the years to expedite drug innovation and R&D, and benefit more patients. Tigermed has signed a framework agreement with shenzhen Pingshan District People's Government to build an integrated service platform for clinical research. Contributed to the biomedical industry in wuxi Case Biomedicine is one of the strategic emerging industries of Wuxi City. Tigermed is the first partner of AstraZeneca in founding Wuxi International Life-science Innovation Campus (iCampus). We hope to share best practices and achievements in international business with innovative pharmaceutical companies, help Chinese companies go international, and introduce foreign innovative drugs and medical devices into China. We are committed to building a patient- centered and innovation-enabling ecosystem across the entire industry chain. Dr. Ye Xiaoping (right front), Chairman of Tigermed, attended the iCampus signing Ceremony. 32 33 Promoting industry develoPment Tigermed Sustainability report sHArING IDEAs AND rEsourCEs WItH INDustrY pEErs Based on professional service capacity in new drug clinical research and rich global resources for collaboration, Tigermed strives to build a high-level exchange and cooperation platform for industry partners at home and abroad. Through sharing best practices and opinions, players in the industry could grasp new frontiers of the industry, come up with new ideas, and thereby generate continuous industry breakthroughs. sharing experience At the 2019 China Clinical Trial organizations . Innovation . Practice summit Forum, Mr. Wu Qiang, Vice President of Tigermed Project Management Department, introduced the development situation of Chinese clinical trial organizations, and shared insights about opportunities and challenges brought by the new early-stage clinical R&D is key to the development of innovative drugs. Tigermed held the seminar clinical trial policy. He also shared the experience of cooperating with clinical trial organizations. on early-stage Clinical R&D of Innovative Drugs to create opportunities for industry peers to share experience and insights in this regard. Tigermed organized the First Anhui Institutional Development Conference to strengthen ties offering advice and suggestions for industry Development between CRos and sMos, and improve the efficiency and quality of clinical trials. Tigermed, together with three subsidiaries: Talent MedConsulting, Frontage Laboratories, and Jiaxing Clinflash, participated in the Third new Drug Clinical Development summit and shared Tigermed participated in the seminar of ICH e8 (R1) Guideline on General Considerations for requirements for new drug application and measures for clinical research risk control. Clinical Trials organized by the national Medical Products Administration, and offered key takeaways from frontline practices to help push the Guideline to enter the third phase. In Tigermed and Korea national enterprise for Clinical Trials (KoneCT) signed an MoU to promote addition, Tigermed was invited to share its experience as a private enterprise in a meeting exchanges, cooperation and experience sharing between CRos in the two countries. soliciting opinions for the Regulations on the Promotion of Private enterprises in Zhejiang Province. experience sharing for gCP improvement tapping the enormous potential of innovative biologic drugs Tigermed shared ways to cut R&D expenditure and shorten the R&D cycle of biosimilars at the 2019 Biopharma Developer Innovation Conference & 1st Turning Point Annual Meeting, to expedite the "go global" of Chinese new drugs. Tigermed exchanges with industry peers Tigermed actively participated in major international conferences, such as the DIA 2019 Global Annual Meeting, the Biotechnology Innovation organization (BIo) International Convention, BIo- europe, europe's largest biotechnology partnering conference, and the 38th Annual J.P. Morgan Healthcare Conference, where the Company shared the latest progress and achievements of Ms. Chang Jianqing, Vice President of Tigermed Policy and Regulations, was invited to the DIA China Drug China's clinical research with international counterparts and built a two-way bridge for high- Discovery Innovation Conference, where she introduced key points relevant to clinical research in the Drug quality medical products at home and abroad. Administration Law of the People's Republic of China. 34 35 Promoting industry develoPment Tigermed Sustainability report our actions value contribution Tigermed works with top hospitals and Tigermed jointly established the Beijing has developed a unique and innovative Clinical Research Ability Training Center CRC training model, which will help the with Beijing Ditan Hospital, Capital Medical domestic healthcare industry build core University. competitiveness. giving lectures Tigermed co-opens courses on Clinical Tigermed jointly develops clinical research- Trial Management with Zhejiang related courses with universities and Pharmaceutical College and Hangzhou colleges, which will help arouse students' Medical College. interest in clinical research, and thereby cultivate talents for the industry. Tigermed built a China-south Korea The China-south Korea clinical research clinical research exchange and cooperation exchange and cooperation platform platform and sent lecturers abroad to give creates good opportunities for building an courses to international industry peers. international industry-university-research team. forms of cooperation Tigermed offers internships for more than 20 universities and colleges including Zhejiang Pharmaceutical College, Tigermed expands employment channels for internships shenyang Pharmaceutical University, college students and creates opportunities nanjing Medical University, Beijing for students to know more about clinical University of Chinese Medicine, Zhejiang research, so as to build a sustainable talent Chinese Medical University, China pool. Pharmaceutical University, and Guangxi Medical University. buILDING A stroNG tALENt pooL Tigermed supports clinical research scholarships Tigermed set up the "Tigermed education by improving school conditions. For HIGH-QuALItY INDustrY scholarship" at Hangzhou Medical College." Tigermed strives to boost its attractiveness to talents and enhance the popularity of clinical research in universities. DEvELopmENt Tigermed carries out extensive cooperation to train talents for the future The CRo industry is currently in a stage of rapid development, with a growing demand for high- Tigermed gives play to its resources and technical expertise to provide financial and technical quality talents. To achieve further progress and high-quality development, advance preparation support for start-up pharmaceutical companies, contributing to the lasting development of the and talent pooling matter. We invest a lot in finding industry talents and building a clinical innovative healthcare industry. research talent pool by adding systematic clinical research courses to the current medical education curriculum and adding clinical research-related content to the standardized training of resident doctors. funded Pharmaceutical start-ups to enable their rapid growth Case At present, pharmaceutical innovation in China is in its infancy, and high-quality innovation projects are often forced into suspension due to lack of financial and technical support. Tigermed students may not have a clear idea of what kind of job they want to take. the project of has directly invested in a number of leading biopharmaceutical companies in China, such as cooperation between schools and enterprises provides us with a valuable opportunity CAnbridge, Genor Biopharma and shanghai Zerun Biotechnology. Among them, shanghai to understand the Cro industry. the project has equipped me with not only theoretical Zerun Biotechnology leads the domestic industry in the clinical progress of the 9-valent HPV knowledge, but also hands-on skills, and prepared me for the industry and the job in a vaccine. And Genor Biopharma plans to launch several new drugs within two years. Besides short time. direct investment, we have also invested in eight leading domestic healthcare funds, in the hope of providing both financial and intellectual support to innovative healthcare industries like ———Xu siqing, an intern and then an employee of Tigermed innovative drugs, innovative medical devices, medical AI, big data, and cellular immunotherapy. Graduated from Zhejiang Pharmaceutical College in 2019 our investment will empower recipient enterprises and drive the development of China's healthcare industry. 36 37 Tigermed Sustainability report GuIDING our pEopLE ENsurING EmpLoYEEs' bAsIC rIGHts AND IN tHE QuEst For INtErEsts suCCEss Our Actions: Protect the fundamental rights and interests of employees Pay attention to employee growth and development ACtIvAtING tALENt Care for female employees AND uNLEAsHING potENtIAL Talents are invaluable assets and the cornerstone of sustainability for Tigermed. We always put people first, respect the value of employees, and support them in career development. While helping employees grow and fulfill themselves, we retain them and grow into a talent- backed industry leader. FostErING AN ENGAGING tIGErmED CuLturE GuidinG Our PeOPle in the Quest fOr success Tigermed Sustainability report a People-centered approach for Common Development Talents define Tigermed's core competitiveness. While we are growing fast, we adopt a more scientific and reasonable approach in selecting, employing, training and retaining talents. our employees have a strong sense of happiness, not only because they echo with our corporate culture, but also because they find Tigermed to be the right place for unleashing their talent. While our employees strive for excellence in Ceo's view work, we give them all-round support and care in mental health counseling, relocation on talents and returning to work after childbirth, etc. such challenges are fully identified and properly handled at Tigermed. We are committed to becoming a talent magnet in the CRo industry and keep investing in a stable and high-quality talent pool. ENsurING EmpLoYEEs' bAsIC Consolidating the Compensation and rIGHts AND INtErEsts Performance management system Tigermed offers diversified salary packages to win the war for talent in the pharmaceutical R&D We act in strict accordance with relevant laws and regulations, such as the Labor Law of the industry. We combine salary with equity incentives, and evaluate the performance of employees People's Republic of China and the Company Law of the People's Republic of China, international 100% by introducing multi-dimensional KPIs to perfectly balance employees' efforts and gains. We have formulated a set of human resource management systems such as the employee Handbook , conventions and labor standards, and eliminate child labor and forced labor. We effectively employee labor contract protect the legitimate rights and interests of employees, and endeavor to maintain equal and signing rate organization Performance Management system , employee Performance Management system and harmonious labor relations. All our employees are treated equally regardless of gender, age, Remuneration Management system , to ensure the openness and transparency of the performance educational background, ethnicity and nationality, and enjoy equal and inclusive development evaluation standards and procedures for directors, supervisors and senior executives, as well as the transparency and law compliance of the appointment of senior executives. and promotion opportunities. 100% Key indicators occupational health and safety social insurance coverage employees Professional teams excellent educational background employees worldwide Tigermed defines occupational health as mental and physical health. To ensure that clinical laboratories are health-friendly and safe, we 4959 have formulated safety management systems such as the Laboratory Technical staff Master's degree Asia-pacific region [China included] Facilities, environment and sanitation Procedures , and Procedures for 4959 89.31% Financial staff 1.63% and above 25.29% 239 Responding Risks and opportunities , to keep testing and environmental number of employees Asia-pacific region [China excluded] facilities under strict control. We also arrange annual health checkups for Marketing employees, and all our employees received health checkups last year. staff 1064 2.88% Administrative Junior college and lower Bachelo's degree 428 north America The CRo industry is full of challenges, and employees face high pressure number of employees of staff from work and interpersonal relationships. To help employees better the parent company 11.71% 63.00% 6.18% 12 address challenges, we have launched the employee Assistance Program europe (eAP), the first of its kind in the CRo industry. Note: The statistics above were current as at the end of December 2019. Please refer to “KEY PERFORMANCE” on P52-53 for more HR statistics. 40 41 GuidinG Our PeOPle in the Quest fOr success Tigermed Sustainability report During the reporting period Sparing no efforts in empowering employees ACtIvAtING tALENt AND Tigermed provides targeted training programs to employees at different levels and uNLEAsHING potENtIAL 3580 Training positions. From new hire training to MBA and eMBA degree education for senior executives, from vocational skill training to management capacity building, we are number of employees trained committed to providing employees with uninterrupted and full-course training resources, to empower them and render them into productive, efficient and creative Tigermed continues to help employees boost their value. We have formulated the Training Management Policy, Personal Training and relative soPs, and on the basis of which, established a 37 talents who have excellent problem-solving skills and take pride in their jobs. Average training hours per full-coverage, multi-pronged training framework. At Tigermed, one can learn anywhere, anytime employee as long as he or she wants. We offer a platform for employees to grow fast, and thus nurture and Project Manager Enabling Program retain the high-quality talent team. 4.67 To help employees better adapt to the new role as Project Manager (hereinafter referred to as PM), grow faster and improve team productivity, Tigermed has customized a two-year Backbone PM enabling Program. The During the reporting Investment in employee training program aims to help PMs consolidate basic know-how, improve the ability of managing clinical trial projects, period (million RMB) strengthen hands-on skills, and thereby lay a solid foundation for career development. Launching the recruitment management system Book-reading and sharing employees formulate IDPs To meet the needs of Tigermed's group-oriented and international development, The Direct Manager provides assistance and and to build an employer brand of Tigermed, we integrate the recruitment of all subsidiaries into one platform, and launch a recruitment management system 192 sharing project management skills lea rn in g ID P reviews IDP progress on a quarterly basis number of employees promoted HRBP serves as the supervisor Selection up for full-process human resource management, including job vacancy posting, through the professional talent Gro candidate screening, ability assessment, and talent pool construction. The platform channel Project review and summary Coaching PMs in key learning points every h a ri n g allows us to continuously improve recruitment efficiency, and find top talents who month, helping them adapt to the new role Coachi Project experience sharing fit in with our vacancies and agree with our corporate values, thus laying a good and build capacity 120 es Case sharing ng foundation for medium and long-term development of Tigermed. Trainees take notes in the monthly coaching as C Training number of employees promoted HRBP serves as the supervisor through the managerial talent channel specialized knowledge Best practices in clinical trial project management General skill training Expanding the career development ladder The PM training program is mainly in five forms: IDP (Individual Development Plan), coaching, training, case sharing, and group learning. It aims to unleash constant and conscious enthusiasm of trainees for learning and We offer a dual career development ladder for technical and managerial talents to growth and enable them to learn by themselves, so as to sustain long-term individual development. give full play to each employee's ability in the most suitable position and to fully recognize the value created by employees in different positions. To meet the needs Employment Private Board meetings for senior executives of business development, we added a site management promotion channel during the reporting period as a novel and exclusive pipeline for CRCs on the frontline of senior executives at Tigermed often need to cope with complex and everchanging issues. only with higher overall quality and leadership can they address challenges smoothly. During the reporting period, we clinical research. organized three private Board meetings for the senior management team and invited coaches to strengthen their leadership and corporate management skills. At the same time, senior executives were paired up to solve management problems together. such methods have helped improve the cohesion and capabilities of our senior management team. internal Job transfer encourages Proactive Career management of employees Case During the reporting period Tigermed is fully aware that employees may seek job transfer at different stages of life Retaining key talents with incentive policies due to personal or family reasons, to obtain opportunities for further fulfilling themselves. During the reporting period, Tigermed continued to foster the KPI-oriented corporate To this end, we have put in place an internal job transfer mechanism. When an employee 535 culture mainly based on company-level and department-level bonuses. We also Key technical (business) Retention released incentive measures such as equity incentives for talents at key positions applies for a job transfer, as long as there is a vacancy and the applicant is qualified, he personnel participating in the equity incentives program and core managerial personnel, and continuously enhanced the competitiveness of or she can switch the role unimpededly. During the reporting period, 55 employees had our overall compensation package to attract outstanding external talents to join us. switched positions, including CRCs, CRAs and senior executives who have been with our employee turnover rate is lower than the industry average. Tigermed for more than 15 years. 42 43 GuidinG Our PeOPle in the Quest fOr success Tigermed Sustainability report FostErING AN supporting work-life balance of employees ENGAGING tIGErmED Tigermed attaches great importance to the work-life balance of employees and encourages employees to work hard and live a healthy life. We vigorously enrich employees' cultural life by CuLturE providing benefits such as badminton clubs, football clubs, photography clubs, and free gyms to ease their work pressure. employees are encouraged to participate in public welfare activities. They donated clothes to Limin Vocational school in Yushu Tibetan Autonomous prefecture Tigermed cares about how employees feel, listens to their needs, and provides them with all- of northwest China's Qinghai Province via the second "Love transcending distance" activity, round care and support, making the Company a big loving family. and donated KRW 2.89 million (about RMB 17,315) to an orphanage in south Korea to support children in need. By doing this, employees themselves have become more responsible and more grateful. an unblocked internal Communication mechanism that allows employees to share their views Tigermed endeavors to establish an efficient internal communication mechanism that meets the new demands brought by business expansion and fresh blood, and ensures the accuracy, timeliness and transparency of information transmission. Senior leadership We inform employees of the Middle management Company's strategy and business performance, commend We optimize the reporting and Employee engagement outstanding employees, and instruction mechanism, and send holiday greetings via the share professional knowledge employees can give feedback email of the President office of and best practices across the and suggestions on corporate Tigermed northern China Badminton Competition 2019 Administration, annual meetings, Company through monthly development through the Caring for female employees celebration activities, and HRBP meetings, Monthly Talking Points internal IT platform, employee email. and live streaming. salons, Tigermed innovation talks and various other channels. Internal Communication Mechanism of Tigermed Tigermed pays attention to the workplace and life challenges faced by female employees, and 68.29% responds to national policies of guaranteeing benefits and career development opportunities for women. We make it easier for female employees to become mothers by providing wedding leave, Women in management maternity leave, breastfeeding leave, prenatal care check-up leave, pregnancy leave, and birth control leave, and allow paternity leave for male employees. According to work arrangements, we create work flexibility for female employees in pregnancy and provide them with child care subsidies of the highest local standard. Moreover, we have set up maternity rooms in the 2.67% Company to support new moms return to work. As of December 31, 2019, more than 1,000 "Tigermed babies" had been born. A year-on-year increase of Reading salon for new employees to be familiar with corporate culture "Tigermed babies" 44 45 Tigermed Sustainability report CoNtrIbutING to A sHArED FuturE GrEEN tIGErmED: strENGtHENING Our Actions: ENvIroNmENtAL Popularize knowledge of clinical trials mANAGEmENt support the "small shield" project for blocking hepatitis B mother-to-child transmission Regulate waste disposal strictly Advocate green office Healthy ecosystem and social system are the foundation for the survival and development of mankind. As a member of the global village, Tigermed links its own development with the goal of sustainable development of the world. While supporting drug R&D to protect people's health, we actively respond to climate change and other environmental challenges faced by the world, and take on the responsibility to increase public CArING tIGErmED: awareness of clinical trials, so as to change the world for ImprovING HEALtH the better. AWArENEss At CommuNItY LEvEL Contributing to a Shared Future Tigermed Sustainability report GrEEN tIGErmED: saving resources strENGtHENING In 2019 We strictly control water and electricity use by continuously strengthening the inspection and maintenance of water equipment and facilities, phasing out outmoded electricity-consuming appliances, and managing water and electricity consumption statistics. We have enhanced ENvIroNmENtAL mANAGEmENt 0.0640 electricity consumption per employees' awareness of resource conservation through communication, putting up slogans on saving water and electricity and other means to help build a resource-saving society. We use capita (10000 kWh) municipal water and haven't posed any major risk to the environment. Tigermed strictly complies with laws and regulations, such as the environmental Protection Purchased electricity by Tigermed's possessed Law of the People's Republic of China . We pursue green development in everyday office tasks and clinical research, and have gradually developed our own eHs (environment, Health and 32.6087 2017 and leased properties (Unit: 10000 kWh) 128.9931 2017 Water consumption (Unit: Ton) 61298 safety) management system by drawing from best practices of advanced industry peers. We Water consumption per capita (ton) are also integrating green development requirements into business operations to reduce our environmental footprint and achieve green development. 2018 125.9178 2018 58268 regulating waste Disposal strictly 2019 103.3363 2019 52663 30 60 90 120 150 50000 53000 56000 59000 62000 The Company's non-hazardous waste mainly includes office wastepaper, cleaning supplies waste, In 2019 food waste, and hazardous waste mainly consists of toxic liquid waste generated during clinical trials. Reducing waste discharge is one of our environmental goals. To fulfill the goal, we sort and manage non-hazardous office waste in a rigorous manner, and handle it to environmental 88.453 non-hazardous waste such as protection authorities for proper treatment on a regular basis. Laboratory environment domestic and office waste (ton) management procedures have been formulated. And a specific department was established to be in charge of registering and handling laboratory waste, helping strengthen laboratory waste treatment and prevent the waste from affecting water and soil. 0.055 emissions per capita (ton) Poured into designated recycling bins for waste liquid and low-toxic and non-toxic waste liquid collected regularly by partner agencies Laboratory waste disposal waste acid and alkali Discharged after being neutralized with dilute alkali or acid Chemical experiments that produce exhaust gases are done We hand over hazardous office exhaust gas waste, such as empty toner in labs with fume hoods to treat and vent exhaust gases cartridges and waste fluorescent Catchy electricity slogan in the office area tubes, to third-party agencies Combating Climate Change everyday solid waste Landfilled after collection or the real estate management service for disposal. In 2019 biological waste Inactivated before disposal As a CRo, Tigermed's day-to-day energy consumption mainly comes from electricity consumption 181.561 of office equipment such as computers and lighting facilities, and oil consumption of vehicles. We keep a close eye on the impact of our daily operation on climate change, and work hard to The Company's total direct and indirect greenhouse gas reduce pollution by launching a remote online collaborative office system, promoting green office emissions decreased by 181.561 (such as replacing printed business cards with electronic ones), and effectively controlling and tons Co2e on a year-on-year managing self-owned vehicles. basis. 831.444 65.834 Note: Please refer to "KEY Indirect greenhouse gas (scope 2) Direct greenhouse gas (scope 1) PERFORMANCE" on P52-53 for the emissions (ton Co2e) emissions (ton Co2e) scope and calculation method of environmental data, and more 0.515 0.041 emissions statistics. emissions per capita (ton Co2e) emissions per capita (ton Co2e) Calculated based on the Company's Calculated based on the Company's purchased electricity gasoline consumption 48 49 Contributing to a Shared Future Tigermed Sustainability report CArING tIGErmED: ImprovING Q Subject A Doctor HEALtH AWArENEss At we answer questions from subjects on the Doctor, are the trials and tests free? What obligations CommuNItY LEvEL CrPf official weChat do I need to fulfill? account: The development of an enterprise is inseparable from the engagement and support of the Hi, we encourage and respect every subject for the clinical trials of a new drug. since community, while the development of a community also requires the invention and contribution the uncertainties and safety issues are unknown before a new drug is launched to the of enterprises. For Tigermed, health is a key issue on our agenda to contribute to community market, to avoid risks, it is necessary for subjects to take regular tests in accordance development. We strive to open a communication channel between the Company and society, with the protocol. In this way, to comply with necessary obligations is to better spread our health philosophy to more people through benign interactions, and thereby enhance protect the rights and interests of subjects themselves, and to ensure the safety of health awareness of the entire society. clinical trials. Popularizing Knowledge about the the CrPf uses vivid Clinical trials of Drugs animation to disseminate knowledge about clinical trials to the media and the Clinical trials are still misunderstood by the general public. Most people believe they will be public: treated like "guinea pigs" in such trials and won't benefit much. However, clinical trial is a key link before bringing a new drug to the market, and the participation of subjects is indispensable. scan the QR code to learn about scan the QR code to learn about clinical trials of new drugs clinical trials of generic drugs In fact, subjects could access new drugs or new therapies with better efficacy for free in clinical trials. Thus, Tigermed is actively popularizing knowledge of clinical trials among the public, helping the general public, especially subjects, know that such trials are scientific and advanced. By doing this, the Company contributes to building a healthy, virtuous, and trustworthy my genuine opinion (on being a subject) is that patients spend less or even no money pharmaceutical R&D ecosystem. to get good treatment, while also providing true data for the r&D of the new drug and paving the way for future drug users. it is beneficial to the subjects themselves, to drug r&D institutions, and to future subjects. In september 2017, Tigermed and large hospitals, pharmaceutical companies and other organizations from across China jointly established the Clinical Research Promotion Fund (CRPF), and opened ———A comment on the CRPF official WeChat account an official WeChat account to popularize clinical research knowledge, publish latest news on clinical research, and educate subjects. blocking mother-to-Child transmission of hepatitis b with the "small shield" In 2015, the "Zero Mother-to-Child Transmission of Hepatitis B" project (the "small shield"), in november 2019 initiated by the Chinese Foundation for Hepatitis Prevention and Control and fully supported The "small shield" APP by Tigermed, was officially launched. With the establishment of the management network that obtained the medical device includes pregnancy demonstration bases, project hospitals and community-level hospitals, and license of Auxiliary Management software for Blocking Mother- with the help of the "small shield" APP, a mobile medical tool developed by the Company's to-Child Transmission of investee Hangzhou slanHealth Co., Ltd., the project aims to carry out follow-up management of Hepatitis B issued by the pregnant women with hepatitis B and their babies in accordance with standard procedures to Zhejiang Medical Products Administration. It was the first minimize or even completely block mother-to-child transmission of the disease. As of the end of officially approved mobile APP the reporting period, the "small shield" project had covered nearly 200 hospitals in 31 provinces, software device license in the municipalities, and autonomous regions, with more than 1,600 registered doctors serving 30,000 field of liver disease prevention and treatment since the expectant mothers carrying hepatitis B virus. The success rate of blocking mother-to-child implementation of the new list. transmission was above 99.5%. 50 51 KeY PeRFoRMAnCe Tigermed Sustainability report Social performance indicator Unit 2019 2018 2017 Total count of active employees / 4959 3898 3214 Female employees / 4217 3233 2667 employees aged 30 and below / 3623 2874 2320 employees aged 31 to 50 / 1296 994 860 employees aged 51 and above / 40 30 34 Women in management % 68.29 65.62 66.84 Average paid vacation days / 13.85 12.34 9.3 Hse investment RMB 10000 740 620 460 Health checkup coverage % 100 100 100 staff turnover rate % 18.7% 20.7% 23.0% Work-related fatalities / 0 0 0 number of suppliers / 1604 1896 1507 Cumulative donations RMB 10000 870.60 767.60 652.60 Environmental performance indicator Unit 2019 2018 2017 KEY non-hazardous waste such as domestic waste and office waste Purchased electricity by Tigermed's possessed and leased Ton 88.453 73.950 59.520 10000 kWh 103.3363 125.9178 128.9931 pErFormANCE properties Water consumption Ton 52663 58268 61298 Mileage of the Company's light vehicles (<=2.5 tons) Kilometer 112567 105548 95477 Economic performance Mileage of the Company's light vehicles (2.5-3.5 tons) Kilometer 132000 130000 135000 indicator Unit 2019 2018 2017 Gasoline consumption Liter 24312 24264 23332 Total assets RMB 100 million 75.33 42.80 35.83 emission of nitrogen oxides Kilogram 252.03 243.51 240.37 operating revenue RMB 100 million 28.03 23.01 16.87 emission of particulates Kilogram 23.74 22.93 22.61 net profit of shareholders of listed companies RMB 100 million 8.42 4.72 3.01 emission of sulfur oxides Kilogram 0.36 0.37 0.34 Taxes payable RMB 100 million 1.12 0.79 0.43 Direct greenhouse gas (scope 1) emissions Ton 65.834 65.704 63.180 Basic earnings per share RMB per share 1.13 0.94 0.61 Indirect greenhouse gas (scope 2) emissions Ton 831.444 1013.135 1037.878 number of R&D personnel / 468 426 378 note 1: The environmental data comes from Tigermed's Hangzhou office, Jiaxing office and shanghai office. The Company will gradually expand Proportion of R&D personnel % 9.44 10.93 11.76 statistics management to cover the entire group. R&D investment RMB 100 million 1.24 0.88 0.50 note 2: The emission of nitrogen oxides and particulate matter are calculated based on the mileage of light vehicles held by the company; the emission of sulfur oxides and direct greenhouse gases (scope 1) are calculated based on gasoline consumption; and the emission of indirect greenhouse gases R&D investment to operating revenue % 4.43 3.83 2.94 (scope 2) are calculated based on purchased electricity. The calculation method is in line with the environmental KPI reporting principles in the environmental, social and Governance Reporting Guide (esG Guide) formulated by Hong Kong stock exchange. The emission coefficient of indirect Drug clinical research project / 287 283 218 greenhouse gases (scope 2) is 0.8046, which is derived from the China Regional Power Grid Baseline emission Factors for emission Reduction Projects in 2017 issued by the Ministry of ecology and environment. 52 53 oUTLooK Tigermed Sustainability report talent strategy In terms of human resource management, we will stick to the people-centered approach for common development, and create a sound development platform Quality and qualification for employees. We retain employees with corporate culture and career growth opportunities, and grow along In an ever changing world, change is the Riding on the global trend of pharmaceutical with them. R&D, we will consolidate soPs of subsidiaries, only constant. successful organizations continuously optimize quality management procedures, and foster a quality culture with bear the mark of the times. full participation of employees, in an effort to build Tigermed into a CRo aligned with global quality management standards. excellent operation ——by John P. Kotter, author of Leading Change We have established a global operation system. With a competent and stable team and reliable quality assurance, we will be able to deliver 100% projects on time with guaranteed quality, and sustain our competitive profitability. market strategy We pay attention to new business drivers such as real-world evidence (RWe), with a focus on Customer first developing non-regulated businesses. We will We are always customer-focused. We will timely learn outLooK go global together with our customers, and build an international operation team with the and analyze the needs and expectations of customers and the market, and continue to optimize customer support of overseas projects of our strategic relationship management, improve the communication customers, so as to expand our market to mechanism and complaint management, and strive to In the global wave of pharmaceutical innovation, the emergence of new technologies like big data the Asia-Pacific, north America and Western become a trustworthy clinical research partner. and AI and breakthrough therapies will change the original CRo model. As China has become europe. the second largest pharmaceutical market in the world, and Healthy China 2030 has become a national strategy, the government is now vigorously promoting pharmaceutical innovation by tigermed will actively embrace the mounting policy, capital, and industry support. era of pharmaceutical r&D and innovation, stand firm on being quality- oriented and innovate in services to cope with changes in the industry and across the world. In 2020, Tigermed will stay true to the mission of "service innovation, health for all" and adhere to the strategy of "excellence in every Trial for every Patient" to serve the cause of innovation-driven development responsibility management innovative medicine. we will orient our efforts toward customer demand and We closely follow frontier technologies in the industry We will further implement the sustainable development globalization, expedite the set-up of a global clinical service network, and develop our own leading technologies based on philosophy by formulating and improving policies and continuously improve the ability of operating and managing global strengths in different business lines. We will follow up and regulations and strengthening the roles of key with innovative business models such as RWe and risk- departments, especially the Board of Directors, in the projects, thus providing integrated solutions and one-stop services for based monitoring (RBM), and improve customer service sustainability management of Tigermed. global pharmaceutical r&D, and contribute to the health of humankind. procedures through innovation. 54 55 Tigermed HonG KonG sToCK eXCHAnGe esG (enVIRonMenTAL, Sustainability report soCIAL AnD GoVeRnAnCe) RePoRTInG GUIDe InDeX HoNG KoNG stoCK EXCHANGE EsG (ENvIroNmENtAL, Information on: We comply with China's laws and regulations, including Work safety Law soCIAL AND GovErNANCE) rEportING GuIDE INDEX (a) the policies; and General of the People's Republic of (b) compliance and material non-compliance with relevant standards, rules and P41 Disclosure China, and Prevention and regulations on providing a safe working environment and protecting employees b2 health and Control of occupational from occupational hazards safety Diseases Law of the This report has complied with the "non-compliance and interpretation" provisions set out in the People's Republic of China environment, social and Governance Reporting Guidelines. B2.1 number and rate of work-related fatalities P53 B2.2 Lost days due to work injury. / Description of occupational health and safety measures adopted, how they are B2.3 P41 implemented and monitored environmental aspect General Policies on improving employees' knowledge and skills for discharging duties at indicator Page note Disclosure work. Description of training activities P42-43 b3 Development Information on: The percentage of employees trained by employee category (e.g. senior and training B3.1 P43 (a) the policies; and management, middle management) General (b) compliance and material non-compliance with relevant standards, rules and P48-49 B3.2 The average training hours completed per employee by employee category P43 Disclosure regulations on air and greenhouse gas emissions, discharges into water and land, and generation of hazardous and non-hazardous waste Information on: General (a) the policies; and P40 A1.1 The types of emissions and respective emissions data P53 Disclosure (b) compliance and material non-compliance with relevant standards, rules and b4 labor regulations on preventing child and forced labor Greenhouse gas emissions in total (in tons) and, where appropriate, intensity (e.g. A1.2 P49 standards per unit of production volume, per facility) Description of measures to review employment practices to avoid child and forced B4.1 P40 a1 emissions labor We entrust a third party to Total hazardous waste produced (in tons) and, where appropriate, intensity (e.g. per dispose of hazardous office B4.2 Description of steps taken to eliminate such practices when discovered / no violation A1.3 P48 unit of production volume, per facility) waste and do not acquire General relevant data Policies on managing environmental and social risks of the supply chain. P11, P29 Disclosure Total non-hazardous waste produced (in tons) and, where appropriate, intensity (e.g. A1.4 P48 B5.1 number of suppliers by geographical region P29 per unit of production volume, per facility) Description of practices relating to engaging suppliers, number of suppliers where A1.5 Description of measures to mitigate emissions and results achieved P48 b5 supply Chain B5.2 P29 the practices are being implemented, how they are implemented and monitored. management Description of how hazardous and non-hazardous wastes are handled, reduction A1.6 P48 Description of practices used to identify environmental and social risks along the initiatives and results achieved B5.3 P29 supply chain, and how they are implemented and monitored. Policies on the efficient use of resources, including energy, water and other raw Description of practices used to promote environmentally preferable products and General materials. B5.4 P29 P49 services when selecting suppliers, and how they are implemented and monitored. Disclosure Resources may be used in production, in storage, transportation, in buildings, electronic equipment, etc. We comply with China's Information on: laws and regulations, Direct and/or indirect energy consumption by type (e.g. electricity, gas or oil) in total A2.1 P49 (a) the policies; and including Drug (kWh in '000s) and intensity (e.g. per unit of production volume, per facility) General (b) compliance and material non-compliance with relevant standards, rules and P26-29 Administration Law of the Disclosurea a2 use of Water consumption in total and intensity (e.g. per unit of production volume, per regulations on health and safety, advertising, labelling and privacy matters relating People's Republic of China, A2.2 P49 resources facility) to products and services provided and methods of redress and Provisions for Drug Registration. A2.3 Description of energy use efficiency initiatives and results achieved P49 Percentage of total products sold or shipped subject to recalls for safety and health Description of whether there is any issue in sourcing water that is fit for purpose, b6 Product B6.1 / no such incident A2.4 P49 reasons. water efficiency initiatives and results achieved responsibility number of products and service related complaints received and how they are dealt our clinical research of B6.2 P27 Total packaging material used for finished products (in tons) and, if applicable, with not with A2.5 drugs do not involve reference to per unit produced applicable packages Description of practices relating to observing and protecting intellectual property B6.3 P12 rights a3 the General Policies on minimizing the operation's significant impact on the environment and P48-49 environment Disclosure natural resources B6.4 Description of quality assurance process and recall procedures. P27-28 and natural Description of the significant impacts of activities on the environment and natural Description of consumer data protection and privacy policies, how they are resources A3.1 P49 B6.5 P26 resources and the actions taken to manage them. implemented and monitored General Information on: Policies on identification and mitigation of significant climate-related issues which Disclosure / General (a) the policies; and aspect 4: have impacted, and those which may impact, the issuer. P10-11 Disclosure (b) compliance and material non-compliance with relevant standards, rules and Climate Change regulations on bribery, extortion, fraud and money laundering Description of the significant climate-related issues which have impacted, and those A4.1 P49 b7 anti- which may impact, the issuer, and the actions taken to manage them. number of concluded legal cases regarding corrupt practices brought against the corruption B7.1 / no such litigation issuer or its employees during the reporting period and the outcomes of the cases. social aspect Description of preventive measures and whistle-blowing procedures, how they are indicator Page note B7.2 P11 implemented and monitored Information on: B7.3 Description of anti-corruption training provided to directors and staff. P10-11 (a) the policies; and General (b) compliance and material non-compliance with relevant standards, rules and Policies on community engagement to understand the communities' needs where P40-41 General Disclosure regulations on compensation and dismissal, recruitment and promotion, working it operates and to ensure its activities take into consideration the communities' P50-51 Disclosure b1 employment hours, rest periods, equal opportunity, diversity, anti-discrimination, and other interests b8 Community benefits and welfare investment Focus areas of contribution (e.g. education, environmental concerns, labor needs, B8.1 P50-51 B1.1 Total workforce by employment type, age group and geographical region P40 health, culture, sport) B1.2 employee turnover rate by age group and geographical region P53 B8.2 Resources contributed (e.g. money or time) to the focus area P53 56 57 GRI (GLoBAL RePoRTInG InITIATIVe) InDeX Tigermed Sustainability report Disclosure items Page note gri 200 economic GRI 103 Management Approach P8-12,P22-29 GrI (GLobAL rEportING INItIAtIvE) gri 201 economic Performance 201-1 Direct economic value generated and distributed 201-3 Defined benefit plan obligations and other retirement plans P52 P41,P43 INDEX gri 203 indirect economic 203-2 significant indirect economic impacts GRI 103 Management Approach P51 P10-11 205-2 Communication and training about anti-corruption policies and gri 205 anti-corruption P10-11 procedures 205-3 Confirmed incidents of corruption and actions taken no corruption This report has been prepared in accordance with the GRI standards: Core option. gri 206 anti-competitive 206-1 Legal actions for anti-competitive behavior, anti-trust, and monopoly no such litigation behavior practices Disclosure items Page note gri 300 environment GRI 103 Management Approach P48-49 102-1 name of the organization P04 gri 302 energy 302-1 energy consumption within the organization P49 102-2 Activities, brands, products, and services P04-06 303-1 Water withdrawal by source P49 gri 303 water 102-3 Location of headquarters P06 303-2 Water sources significantly affected by withdrawal of water P49 no such influence 102-4 Location of operations P06 305-1 Direct (scope 1) GHG emissions P49 102-5 ownership and legal form P04 305-2 energy indirect (scope 2) GHG emissions P49 102-6 Markets served P06 gri 305 emissions 305-5 Reduction of GHG emissions P49 organizational profile 102-7 scale of the organization P06,P40 305-7 nitrogen oxides (noX), sulfur oxides (soX), and other significant air P53 emissions 102-8 Information on employees and other workers P40 306-2 Waste by type and disposal method P48 102-9 supply chain P29 gri 306 effluents and waste 306-3 significant spills no significant spills 102-10 significant changes to the organization and its supply chain P08 gri 307 environmental 102-11 Precautionary Principle or approach P12 307-1 non-compliance with environmental laws and regulations no violation Compliance 102-13 Membership of associations P24 gri 400 society GRI 103 Management Approach P38-44,P50-51 102-14 statement from senior decision-maker P02-03 401-1 new employee hires and employee turnover P53 strategy 102-15 Key impacts, risks, and opportunities P02-03,P12 gri 401 employment 401-2 Benefits provided to full-time employees that are not provided to P40-43 102-16 Values, principles, standards, and norms of behavior P06 temporary or part-time employees ethics and integrity 102-17 Mechanisms for advice and concerns about ethics P12 404-1 Average hours of training per year per employee P43 gri 404 training and 102-18 Governance structure P08 education 404-2 Programs for upgrading employee skills and transition assistance P42-43 programs 102-29 Identifying and managing economic, environmental, and social impacts P14 GRI 103 Management Approach P40 governance 102-30 effectiveness of risk management processes P12 gri 405 Diversity and equal 405-1 Diversity of governance bodies and employees P40 102-31 Review of economic, environmental, and social topics P14 opportunity 405-2 Ratio of basic salary and remuneration of women to men P41 102-32 Highest governance body's role in sustainability reporting P13 gri 406 non-discrimination 406-1 Incidents of discrimination and corrective actions taken no discrimination 102-40 List of stakeholder groups P15 gri 408 Child labor 408-1 operations and suppliers at significant risk for incidents of child labor no such incident 102-42 Identifying and selecting stakeholders P15 gri 409 forced or 409-1 operations and suppliers at significant risk for incidents of forced or 102-43 Approach to stakeholder engagement P15 no such incident Compulsory labor compulsory labor 102-44 Key topics and concerns raised P15 gri 411 rights of indigenous 411-1 Incidents of violations involving rights of indigenous peoples P10 no such incident Peoples 102-46 Defining report content and topic Boundaries P15,P60 GRI 103 Management Approach P45,P5-51 102-47 List of material topics P15 gri 413 local Communities 413-2 operations with significant actual and potential negative impacts on local no such location of no restatements of 102-48 Restatements of information communities operations information stakeholder engagement gri 414 supplier social no significant 414-1 new suppliers that were screened using social criteria P11 102-49 Changes in reporting assessment changes 417-1 Requirements for product and service information and labeling P26 102-50 Reporting period P60 gri 417 marketing and 417-2 Incidents of non-compliance concerning product and service information 102-51 Date of most recent report P60 no such incident labeling and labeling 102-52 Reporting cycle P60 417-3 Incidents of non-compliance concerning marketing communications no such incident 102-53 Contact point for questions regarding the report P60 GRI 103 Management Approach P10-12 102-54 Claims of reporting in accordance with the GRI standards P58 gri 419 socioeconomic Compliance 419-1 non-compliance with laws and regulations in the social and economic no violation 102-55 GRI content index P58 area 58 59 Tigermed Sustainability report About tHIs rEport reporting Period The time frame for the report is January 1 to December 31, 2019, though some contents may extend beyond the stated reporting period. release Cycle The report is released annually. And the first social responsibility report was released on August 22, 2019. reporting boundary This report covers Tigermed's headquarters and subsidiaries. For the convenience of readers, "Hangzhou Tigermed Consulting Co., Ltd." is also referred to as "Tigermed", "the Company" and "we" in the report. "Hangzhou simo Co., Ltd." is referred to as "Hangzhou simo". "Macrostat (China) Clinical Research Co., Ltd." is referred to as "Macrostat". "Jiaxing Tigermed Data Management Co., Ltd." is referred to as "Jiaxing Tigermed". "Jiaxing Clinflash Computer Technology Co., Ltd." is referred to as "Jiaxing Clinflash". "Hangzhou Talent MedConsulting Co., Ltd." is referred to as "Talent MedConsulting". "Frontage Laboratories, Inc." is referred to as "Frontage Laboratories". "Fantastic Bioimaging Co., Ltd." is referred to as "Fantastic Bioimaging", and "Teddy Clinical Research Laboratory (shanghai) Limited" is referred to as "shanghai Teddy". reporting Commitment Tigermed assures that the report contains no false records, misleading information or material omission, and is responsible for the authenticity, accuracy, and integrity of its content. Data sources Data in the report is mainly from the statistical reports and official documents of Tigermed from January 1 to December 31, 2019. Compilation Conformance This report is compiled in accordance with the Iso 26000: Guidance on social Responsibility , the GRI sustainability Reporting standards (GRI standards) issued by Global sustainability standard Board (GssB) and the environmental, social and Governance Reporting Guide (esG Guide) formulated by Hong Kong stock exchange. Contact us Corporate social Responsibility Department, Tigermed email:CsR@tigermedgrp.com For more information about Tigermed's CsR practices, please go to https://tigermedgrp.com/ note: Tigermed's headquarters (Hangzhou) relocation is estimated to be completed by the end of scan the QR code to give August 2020. Please refer to our official website for the new address. feedback on the report. 60