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公司公告

康龙化成:H股公告2021-06-21  

                                                                         32

571




           1933
                                  S          S




                Pharmaron Beijing Co., Ltd.*


                                      3759




      300.0            2026
                                        40725

      1,916.0         2026
                                        40733




                              1
    37.39A




                      37




2021    6    21




*




                  2
                                                     IMPORTANT

              NOT FOR DISTRIBUTION TO ANY PERSON OR ADDRESS IN THE UNITED STATES

IMPORTANT: You must read the following before continuing. The following applies to the attached offering circular
following this page, and you are therefore advised to read this carefully before reading, accessing or making any other use
of the attached offering circular. In accessing the attached offering circular, you agree to be bound by the following terms
and conditions, including any modifications to them any time you receive any information from us as a result of such access.

NOTHING IN THIS ELECTRONIC TRANSMISSION CONSTITUTES AN OFFER OF SECURITIES FOR SALE IN
THE UNITED STATES OR ANY OTHER JURISDICTION WHERE IT IS UNLAWFUL TO DO SO. THE
SECURITIES HAVE NOT BEEN, AND WILL NOT BE, REGISTERED UNDER THE UNITED STATES
SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY
STATE OF THE UNITED STATES OR OTHER JURISDICTION AND THE SECURITIES MAY NOT BE OFFERED
OR SOLD WITHIN THE UNITED STATES, EXCEPT PURSUANT TO AN EXEMPTION FROM, OR IN A
TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND
APPLICABLE STATE OR LOCAL SECURITIES LAWS.

THIS OFFERING CIRCULAR MAY NOT BE FORWARDED OR DISTRIBUTED TO ANY OTHER PERSON AND
MAY NOT BE REPRODUCED IN ANY MANNER WHATSOEVER, AND IN PARTICULAR, MAY NOT BE
FORWARDED TO ANY ADDRESS IN THE UNITED STATES. ANY FORWARDING, DISTRIBUTION OR
REPRODUCTION OF THIS DOCUMENT IN WHOLE OR IN PART IS UNAUTHORIZED. FAILURE TO COMPLY
WITH THIS DIRECTIVE MAY RESULT IN A VIOLATION OF THE SECURITIES ACT OR THE APPLICABLE
LAWS OF OTHER JURISDICTIONS.

Confirmation of your Representation: This offering circular is being sent to you at your request and by accepting the
e-mail and accessing this attached offering circular, you shall be deemed to have represented to us that the e-mail address
that you gave us and to which this e-mail has been delivered is not located in the United States and that you consent to
delivery of the attached offering circular and any amendments or supplements thereto by electronic transmission.

Actions that You May Not Take: If you receive this document by e-mail, you should not reply by e-mail to this electronic
transmission, and you may not purchase any securities by doing so. Any reply e-mail communications, including those you
generate by using the “Reply” function on your e-mail software, will be ignored or rejected.

You are reminded that this offering circular has been delivered to you on the basis that you are a person into whose
possession this offering circular may be lawfully delivered in accordance with the laws of the jurisdiction in which you are
located and you may not, nor are you authorized to, deliver this offering circular to any other person.

The materials relating to the offering of securities to which this offering circular relates do not constitute, and may not be
used in connection with, an offer or solicitation in any place where offers or solicitations are not permitted by law. If a
jurisdiction requires that the offering be made by a licensed broker or dealer and the Joint Lead Managers or any affiliate
of the Joint Lead Managers is a licensed broker or dealer in that jurisdiction, the offering shall be deemed to be made by
the Joint Lead Managers or such affiliate on behalf of the Issuer (as defined in this offering circular) in such jurisdiction.

This offering circular has been sent to you in an electronic form. You are reminded that documents transmitted via this
medium may be altered or changed during the process of electronic transmission and consequently none of the Issuer,
Goldman Sachs (Asia) L.L.C., CLSA Limited and J.P. Morgan Securities plc (the “Joint Lead Managers” and “Joint
Bookrunners”), any person who controls the Issuer, the Joint Lead Managers, or any director, officer, employee or agent
of the Joint Lead Managers, or affiliate of any such person accepts any liability or responsibility whatsoever in respect of
any difference between this offering circular distributed to you in electronic format and the hard copy version available to
you on request from the Joint Lead Managers.

You are responsible for protecting against viruses and other destructive items. Your use of this e-mail is at your own risk
and it is your responsibility to take precautions to ensure that it is free from viruses and other items of a destructive nature.
                                         Pharmaron Beijing Co., Ltd.*
                                            (    )
                   (A joint stock company incorporated in the People’s Republic of China with limited liability)
                                                                    (stock code: 3759)
      US$300,000,000 Zero Coupon Convertible Bonds due 2026 (the “Series 1 Bonds”)
    RMB1,916,000,000 Zero Coupon USD Settled Convertible Bonds due 2026 (the “Series 2
                                           Bonds”)
                      Issue Price for the Series 1 Bonds: 100 per cent.
                      Issue Price for the Series 2 Bonds: 100 per cent.
The zero coupon convertible bonds due 2026 in the aggregate principal amount of US$300,000,000 (the “Series 1 Bonds”) and the zero coupon convertible bonds
due 2026 in the aggregate principal amount of RMB1,916,000,000 (the “Series 2 Bonds”, and together with the Series 1 Bonds, the “Bonds” and each a “Series”,
which term shall include, unless the context requires otherwise, any further bonds issued in accordance with the terms and conditions of each series of the Bonds
set out in “Terms and Conditions of the Series 1 Bonds” and “Terms and Conditions of the Series 2 Bonds” (together, the “Conditions” or the “Terms and Conditions”
and each of the Conditions, a “Condition” and the Terms and Conditions shall mean the Terms and Conditions of the Series 1 Bonds or the Series 2 Bonds as the
context requires) will be issued by Pharmaron Beijing Co., Ltd.* (the “Company”, the “Issuer”, “Pharmaron”, “we” or “us”).
The Bonds will constitute direct, unsubordinated, unconditional and (subject to Condition 3.1 (Negative Pledge) of the Terms and Conditions) unsecured obligations
of the Issuer and shall at all times rank pari passu and without any preference or priority among themselves. The payment obligations of the Issuer under the Bonds
shall, save for such exceptions as may be provided by mandatory provisions of applicable law and subject to Condition 3.1 of the Terms and Conditions, at all times
rank at least equally with all of its other present and future direct, unsubordinated, unconditional and unsecured obligations.
Each Bond will, at the option of the holder, be convertible (unless previously redeemed, converted or purchased and canceled) at any time on or after the 41st day
after June 18, 2021 (the “Issue Date”) up to the close of business (at the place where the Certificate evidencing such Bond is deposited for conversion) on the date
falling 10 working days prior to the Maturity Date (as defined herein) of each respective Series (both days inclusive) into fully paid ordinary H Shares with a nominal
value of RMB1.00 each of the Company (the “Shares”) at an initial conversion price of HK$250.75 per Share for Series 1 Bonds and HK$229.50 per Share for Series
2 Bonds, respectively, with a fixed exchange rate of HK$ 7.7588 to US$1.00 and a fixed exchange rate of HK$1.2143 to RMB1.00 (each, a “Fixed Exchange Rate”).
The conversion price is subject to adjustment in the circumstances described under “Terms and Conditions of the Series 1 Bonds – Conversion” and “Terms and
Conditions of the Series 2 Bonds – Conversion”.
The Bonds are zero coupon and do not bear interest unless, upon due presentation thereof, payment of principal and premium (if any) is improperly withheld or
refused.
Unless previously redeemed, converted or purchased and canceled as provided in the Terms and Conditions, the Issuer will redeem each Series 1 Bond at 100.0 per
cent. of its principal amount and each Series 2 Bond at the U.S. Dollar Equivalent (as defined therein) of 107.76% of its principal amount on the Maturity Date. On
giving not less than 30 nor more than 60 days’ notice, the Issuer may redeem the Bonds in whole, but not in part at, in respect of the Series 1 Bonds, the principal
amount, and in respect of the Series 2 Bonds, the U.S. Dollar Equivalent of the Early Redemption Amount as of the date specified for redemption, in relation to the
Series 1 Bonds only (i) at any time after June 18, 2024 but prior to the Maturity Date, subject to certain conditions as specified in the Terms and Conditions, or in
relation to both Series (ii) at any time if, the aggregate principal amount of the Bonds outstanding is less than 10 per cent. of the aggregate principal amount originally
issued (which shall for this purpose include any further bonds issued in accordance with Condition 15 (Further Issues) of the Terms and Conditions and consolidated
and forming a single series therewith) (which shall for this purpose include any further bonds issued in accordance with Condition 15 (Further Issues) of the Terms
and Conditions and consolidated and forming a single series therewith) has already been converted, redeemed or purchased and canceled. The Bonds may also be
redeemed, at the option of the Issuer in whole, but not in part, at any time, on giving not less than 30 nor more than 60 days’ notice, at, in respect of the Series 1
Bonds, the principal amount, and in respect of the Series 2 Bonds, the U.S. Dollar Equivalent of the Early Redemption Amount as of the date of redemption in the
event of certain changes or amendments relating to the People’s Republic of China (the “PRC”) or Hong Kong taxation, as further described in the Terms and
Conditions, subject to the non-redemption option of each holder after the exercise by the Issuer of its tax redemption option as described in the Terms and Conditions.
The holder of each Bond will also have the right at such holder’s option, to require the Issuer to redeem all or some only of such holder’s Bonds at, in relation to
the Series 1 Bonds, their principal amount, and in relation to the Series 2 Bonds, the U.S. Dollar Equivalent of the Early Redemption Amount as of the date of
redemption following the occurrence of a Relevant Event (as defined in the Terms and Conditions). See “Terms and Conditions of the Series 1 Bonds – Redemption,
Purchase and Cancellation” and “Terms and Conditions of the Series 2 Bonds – Redemption, Purchase and Cancellation”. The holder of each Bond will also have
the right at such holder’s option, to require the Issuer to redeem all or some only of the Bonds of such holder on June 18, 2024 (the “Put Option Date”) at, in relation
t o the Series 1 Bonds, 100.0 per cent., and in relation to the Series 2 Bonds, the U.S. Dollar Equivalent of 104.59 per cent. of their principal amount.
Application will be made to the The Stock Exchange of Hong Kong Limited (the “Hong Kong Stock Exchange”) for the permission to deal in, and for the listing
of, the Bonds on the Hong Kong Stock Exchange by way of debt issues to professional investors (as defined in Chapter 37 of the Rules Governing the Listing of
Securities on The Stock Exchange of Hong Kong Limited (the “Listing Rules”) ) (“Professional Investors”) only. This document is for distribution to Professional
Investors only. Notice to Hong Kong investors: The Issuer confirms that the Bonds are intended for purchase by Professional Investors only and will be listed on
the Hong Kong Stock Exchange on that basis. Accordingly, the Issuer confirms that the Bonds are not appropriate as an investment for retail investors in Hong Kong.
Investors should carefully consider the risks involved.
The Hong Kong Stock Exchange has not reviewed the contents of this document, other than to ensure that the prescribed form disclaimer and responsibility
statements, and a statement limiting distribution of this document to Professional Investors only have been reproduced in this document. Listing of the Bonds
on the Stock Exchange is not to be taken as an indication of the commercial merits or credit quality of the Bonds or the Issuer, or quality of disclosure in
this document. Hong Kong Exchanges and Clearing Limited and the Hong Kong Stock Exchange take no responsibility for the contents of this document, make no
representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole
or any part of the contents of this document.
This document includes particulars given in compliance with the Listing Rules for the purpose of giving information with regard to the Issuer. The Issuer accepts
full responsibility for the accuracy of the information contained in this document and confirms, having made all reasonable enquiries, that to the best of its knowledge
and belief there are no other facts the omission of which would make any statement herein misleading.
Investing in the Bonds and the Shares involves certain risks. See “Risk Factors” beginning on page 31 for a discussion of certain factors to be considered
in connection with the investment in the Bonds and the Shares. Specifically, investors should be aware that the Bonds are convertible into ordinary H Shares of
the Company and that there are various other risks relating to the Bonds, the Issuer and its subsidiaries, their business and their jurisdictions of operations which
investors should familiarise themselves with before making an investment in the Bonds. See “Risk Factors” in relation to the convertible feature beginning on page
54.
The Bonds and the Shares to be issued upon conversion of the Bonds have not been and will not be registered under the United States Securities Act of 1933,
as amended (the “Securities Act”), or other securities laws and, subject to certain exceptions, may not be offered or sold within the United States. The Bonds
are being offered and sold only outside the United States in reliance on Regulation S under the Securities Act (“Regulation S”). For a description of these
and certain further restrictions on offers and sales of the Bonds and the Shares to be issued upon conversion of the Bonds and the distribution of this Offering
Circular, see “Subscription and Sale.”
Each Series of the Bonds will be represented by beneficial interests in a global certificate (each, a “Global Certificate”, and together, the “Global Certificates”)
in registered form, which will be registered in the name of a nominee of, and shall be deposited on or about the Issue Date, with a common depositary for, Euroclear
Bank SA/NV (“Euroclear”) and Clearstream Banking S.A. (“Clearstream”). Beneficial interests in the Global Certificate will be shown on, and transfers thereof
will be effected only through, records maintained by Euroclear and Clearstream. Except in the limited circumstances as described herein, certificates for Bonds will
not be issued in exchange for interests in the Global Certificate.

                          Joint Global Coordinators, Joint Lead Managers and Joint Bookrunners

                             Goldman Sachs (Asia) L.L.C.                                                CLSA Limited

                                                Joint Bookrunners and Joint Lead Managers

      Goldman Sachs (Asia) L.L.C.                                        CLSA Limited                                J.P. Morgan Securities plc

                                       The date of this Offering Circular is June 8, 2021

*        For identification purpose only
                                       IMPORTANT NOTICE

This Offering Circular includes particulars given in compliance with the Listing Rules for the purpose of
giving information with regard to the Issuer. The Issuer accepts full responsibility for the accuracy of the
information contained in this Offering Circular and confirms, having made all reasonable enquiries, that to
the best of its knowledge and belief there are no other facts the omission of which would make any
statement herein misleading.

The Company, having made all reasonable enquiries, confirms that (i) this Offering Circular contains all
information with respect to the Company, and to the Company and its subsidiaries (collectively, the
“Group”) and to the issue of the Bonds and Shares, which is material in the context of the issue and offering
of the Bonds (the “Offering”) (including all information which, according to the particular nature of the
Company, the Group and of the Bonds and the Shares, is necessary to enable investors to make an informed
assessment of the assets and liabilities, financial position, profits and losses and prospects of the Company,
the Group, the Bonds and the Shares), (ii) all statements of fact relating to the Company, the Group and to
the Bonds and the Shares contained in this Offering Circular are in all material respects true and accurate
and not misleading, and that there are no other facts in all material respects in relation to the Company, the
Group and to the Bonds and the Shares the omission of which would in the context of the issue and offering
of the Bonds make any statement in this Offering Circular misleading, (iii) the statements of intention,
opinion, belief or expectation with regard to the Company and the Group contained in this Offering Circular
are honestly made or held and have been reached after considering all relevant circumstances and have been
based on reasonable assumptions and (iv) all reasonable enquiries have been made by the Company to
ascertain such facts and to verify the accuracy of all such information and statements in this Offering
Circular. The Company accepts full responsibility for the information contained in this Offering Circular.

This Offering Circular has been prepared by the Company solely for use in connection with the proposed
offering of the Bonds described in this Offering Circular and may not be reproduced, redistributed or made
available in whole or in part to any other person for any purpose. The distribution of this Offering Circular
and the offering of the Bonds in certain jurisdictions may be restricted by law. Persons into whose
possession this Offering Circular comes are required by the Company and the Joint Lead Managers to
inform themselves about and to observe any such restrictions. No action is being taken to permit a public
offering of the Bonds or the distribution of this document in any jurisdiction where action would be required
for such purposes. There are restrictions on the offer and sale of the Bonds, and the circulation of documents
relating thereto, in certain jurisdictions including the United States, the United Kingdom, European
Economic Area (“EEA”), the PRC, Hong Kong, Singapore, Japan and the Cayman Islands, and to persons
connected therewith. For a description of certain further restrictions on offers, sales and resales of the
Bonds and distribution of this Offering Circular, see “Subscription and Sale”.

Each prospective investor acknowledges that it is purchasing the Bonds for its own account and not with
a view to distribution thereof, and it is, or at the time of its purchase will be, the beneficial owner of the
Bonds purchased and (i) outside the United States; and (ii) not an affiliate of the Issuer or a person acting
on behalf of such an affiliate. Each prospective investor acknowledges that its purchase of the Bonds is
lawful under the securities laws of the jurisdiction in which such prospective investor accepts the offer to
purchase the Bonds.

The completion of the Offering is subject to the satisfaction and/or waiver of customary conditions
precedent and the Joint Lead Managers may exercise their discretion to terminate the transaction for reasons
set forth in the Subscription Agreement (as defined below). Each person receiving this Offering Circular
represents and acknowledges that none of the Joint Lead Managers will be held liable for any damages as
a result of non-completion of the Offering or for the exercise of such rights or discretion.

No person has been or is authorized to give any information or to make any representation concerning the
Company, the Group or the Bonds other than as contained herein and, if given or made, any such other
information or representation should not be relied upon as having been authorized by the Company, the
Joint Lead Managers, Citicorp International Limited as the trustee (the “Trustee”) or the Agents (as defined


                                                       i
in “Terms and Conditions of the Bonds”). Neither the delivery of this Offering Circular nor any offering,
sale or delivery made in connection with the issue of the Bonds shall, under any circumstances, constitute
a representation that there has been no change or development reasonably likely to involve a change in the
affairs of the Company, the Group or any of them since the date hereof or create any implication that the
information contained herein is correct as of any date subsequent to the date hereof. This Offering Circular
does not constitute an offer of, or an invitation by or on behalf of the Company, the Joint Lead Managers,
the Trustee or the Agents to subscribe for or purchase any of the Bonds and may not be used for the purpose
of an offer to, or a solicitation by, anyone in any jurisdiction or in any circumstances in which such offer
or solicitation is not authorized or is unlawful.

None of the Joint Lead Managers, the Trustee or the Agents or any of their respective directors, officers,
employees, agents, advisers, representatives or affiliates has separately verified the information contained
in this Offering Circular and none of them can give any assurance that this information is accurate, truthful
or complete. Accordingly, no representation, warranty or undertaking, express or implied, is made and no
responsibility or liability is accepted, by the Joint Lead Managers, the Trustee or the Agents or any of their
respective directors, officers, employees, agents, advisers, representatives or affiliates as to the accuracy,
completeness or sufficiency of the information contained in this Offering Circular or any other information
supplied in connection with the Bonds or Shares, and nothing contained in this Offering Circular is, or shall
be relied upon as, a promise, recommendation, representation or warranty, express or implied, by the Joint
Lead Managers, the Trustee, the Agents or any of their respective directors, officers, employees, agents,
advisers, representatives or affiliates. This Offering Circular is not intended to provide the basis of any
credit or other evaluation nor should it be considered as a recommendation by the Company, the Joint Lead
Managers, the Trustee, the Agents or any of their respective directors, officers, employees, agents, advisers,
representatives or affiliates that any recipient of this Offering Circular should purchase the Bonds.

Each prospective investor agrees not to hold the Joint Lead Managers, the Trustee, the Agents or any of their
respective directors, officers, employees, agents, advisers, representatives or affiliates responsible for any
misstatements in or omissions from this Offering Circular. Each person receiving this Offering Circular
acknowledges that such person has not relied on any investigation or due diligence conducted by the Joint
Lead Managers, the Trustee, the Agents or any of their respective directors, officers, employees, agents,
advisers, representatives or affiliates in connection with its investigation of the accuracy of such
information or its investment decision, and each such person must rely on its own examination of the
Company and the Group and the merits and risks involved in investing in the Bonds. Each prospective
investor of the Bonds should determine for itself the relevance of the information contained in this Offering
Circular and its purchase of the Bonds should be based upon such investigations with its own tax, legal and
business advisers as it deems necessary.

In making an investment decision, investors must rely on their own examination of the Company, the Group
and the terms of the offering of the Bonds, including the merits and risks involved. Each prospective
investor acknowledges that it has such knowledge and experience in financial, business and international
investment matters such that it is capable of evaluating the merits and risks of investing in the Bonds, and
understands that entering into the Offering involves a high degree of risk and that the Bonds are a
speculative investment. See “Risk Factors” for a discussion of certain factors to be considered in connection
with an investment in the Bonds. Each prospective investor acknowledges that the Shares are listed on the
Hong Kong Stock Exchange and the Company is therefore required to publish certain business and financial
information in accordance with the rules and practices of the Hong Kong Stock Exchange, which includes,
among other things, descriptions of the Group’s principal activities, and the balance sheets, income
statements and cash flow statements and other information relating to the Group which is necessary to
enable holders of the Shares and the public to appraise the position of the Company and the Group, and each
prospective investor is able to obtain or access such information without undue difficulty. Nothing herein
shall be construed as a recommendation to each such person to purchase the Bonds. To the fullest extent
permitted by law, none of the Joint Lead Managers, the Trustee, the Agents or any of their respective
directors, officers, employees, agents, advisers, representatives or affiliates accepts any responsibility for
the contents of this Offering Circular.


                                                      ii
Each of the Joint Lead Managers, the Trustee, the Agents and their respective directors, officers, employees,
agents, advisers, representatives or affiliates accordingly disclaims all and any liability whether arising in
tort or contract or otherwise which it might otherwise have in respect of this Offering Circular or any such
statement. None of the Joint Lead Managers, the Trustee, the Agents or any of their respective directors,
officers, employees, agents, advisers, representatives or affiliates undertakes to review the Company’s or
the Group’s business, financial condition, results of operations, prospects or affairs after the date of this
Offering Circular nor to advise any investor or potential investor in the Bonds of any information coming
to the attention of any of the Joint Lead Managers, the Trustee, the Agents or any of their respective
directors, officers, employees, agents, advisers, representatives or affiliates.

Listing of the Bonds on the Hong Kong Stock Exchange is not to be taken as an indication of the merits
of the Company, the Group, the Bonds or the Shares. In making an investment decision, prospective
investors must rely on their examination of the Company, the Group and the terms of this Offering,
including the merits and risks involved. The Bonds have not been approved or recommended by any Hong
Kong or other regulatory authority. Furthermore, the contents of this Offering Circular have not been
reviewed by any Hong Kong or other regulatory authority. The foregoing authorities have not passed upon
or endorsed the merits of the Offering or confirmed the accuracy or determined the adequacy of this
Offering Circular. Prospective investors should not construe anything in this Offering Circular as legal,
business or tax advice. Each prospective investor should determine for itself the relevance of the
information contained in this Offering Circular and consult its own legal, business and tax advisers as
needed to make its investment decision and determine whether it is legally able or advisable to purchase
the Bonds under applicable laws or regulations.

Singapore SFA Product Classification – In connection with Section 309B of the Securities and Futures
Act (Chapter 289) of Singapore (the “SFA”) and the Securities and Futures (Capital Markets Products)
Regulations 2018 of Singapore (the “CMP Regulations 2018”), the Issuer has determined, and hereby
notifies all relevant persons (as defined in Section 309A(1) of the SFA), that the Bonds are ‘prescribed
capital markets products’ (as defined in the CMP Regulations 2018) and are Excluded Investment Products
(as defined in MAS Notice SFA 04-N12: Notice on the Sale of Investment Products and MAS Notice
FAA-N16: Notice on Recommendations on Investment Products).




                                                     iii
                               FORWARD-LOOKING STATEMENTS

This Offering Circular includes “forward-looking statements”. All statements other than statements of
historical fact contained in this Offering Circular, including, without limitation, those regarding the
Company’s and the Group’s future financial position and results of operations, strategy, plans, objectives,
goals and targets, future developments in the markets where the Company or the Group participates or is
seeking to participate, and any statements preceded by, followed by or that include the words “believe”,
“expect”, “aim”, “intend”, “will”, “may”, “anticipate”, “seek”, “should”, “estimate” or similar expressions
or the negatives thereof, are forward-looking statements. These forward-looking statements involve known
and unknown risks, uncertainties and other factors, some of which are beyond the Company’s or the Group’s
control, which may cause its actual results, performance or achievements, or industry results to be
materially different from any future results, performance or achievements expressed or implied by the
forward-looking statements. These forward-looking statements are based on numerous assumptions
regarding the Company’s and the Group’s present and future business strategies and the environment in
which the Company or the Group will operate in the future. Important factors that could cause the
Company’s or the Group’s actual results, performance or achievements to differ materially from those in the
forward-looking statements include regional, national or global political, economic, business, competitive,
market and regulatory conditions and the following:

      the Group’s operations and business prospects;

      business strategies and plans to achieve these strategies;

      future developments, trends and conditions in and competitive environment for the industries and
      markets in which the Group operates;

      general economic, political and business conditions in locations where the Group operates;

      the Group’s financial condition, performance and results of operations;

      the Group’s capital expenditure plans;

      various business opportunities that the Group may pursue;

      availability of and changes to bank loans and other forms of financing;

      the Group’s ability to expand and manage its growth, both within the PRC and abroad;

      the Group’s dividend policy;

      changes to the regulatory environment, politics, operating conditions of and general outlook in the
      industries and markets in which the Group operates;

      possible disruptions to commercial activities due to natural and human-induced disasters, including,
      but not limited to, floods, earthquakes, epidemics, terrorist attacks and armed conflicts;

      the Group’s expectation with respect to the ability to acquire and maintain regulatory licenses or
      permits;

      the amount and nature of, and potential for, future development of the Group’s business;

      the actions of and developments affecting competitors of the Group;

      the actions of and development affecting the major customers and suppliers of the Group;

      certain statement in the Offering Circular with respect to overall market trends;


                                                             iv
     changes in currency exchange control and rates; and

     other factors beyond the Group’s control.

Additional factors that could cause actual results, performance or achievements to differ materially include,
but are not limited to, those discussed in “Risk Factors” and elsewhere in this Offering Circular. The
Company cautions investors not to place undue reliance on these forward-looking statements which reflect
its managements’ view only as of May 31, 2021. The Company does not undertake any obligation to update
or revise any forward-looking statements, whether as a result of new information, future events or
otherwise. In light of these risks, uncertainties and assumptions, the forward-looking events discussed in
this Offering Circular might not occur.




                                                     v
                  PRESENTATION OF FINANCIAL INFORMATION

The Company’s consolidated statements of profit or loss, consolidated statements of comprehensive income
and consolidated statements of financial position as of December 31, 2018, 2019 and 2020 and for the years
ended December 31, 2018, 2019 and 2020 have been extracted from the consolidated financial statements
of the Company for the years ended December 31, 2018, 2019 and 2020 contained in the prospectus of the
Company dated November 14, 2019 (the “Prospectus”) and/or the Company’s 2020 annual report (“2020
Annual Report”), which have been audited by Ernst & Young, Certified Public Accountants, and
incorporated by reference in this Offering Circular. The Company prepares its consolidated financial
statements in accordance with the International Financial Reporting Standards (“IFRSs”).

The audited consolidated financial statements of the Company (including the related audit reports and the
notes thereto) which are contained in pages I-1 to I-93 of the Prospectus, pages 121 to 217 of the 2020
Annual Report are incorporated by reference in this Offering Circular. Copies of the Prospectus, the 2020
Annual Report are available and may be downloaded free of charge from the website of the Hong Kong
Stock Exchange at www.hkexnews.hk.

Certain amounts and percentages included in this Offering Circular have been rounded. Accordingly, in
certain instances, the sum of the numbers in a column may not exactly equal the total figure for that column.
You should not construe any exchange rate translations as representations that the relevant exchange and
amounts could actually be converted into the amounts expressed.




                                                     vi
                                                 TABLE OF CONTENTS
IMPORTANT NOTICE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .             i
FORWARD-LOOKING STATEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                          iv
PRESENTATION OF FINANCIAL INFORMATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                                 vi
SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .      1
THE OFFERING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .         5
SELECTED CONSOLIDATED FINANCIAL INFORMATION OF THE COMPANY . . . . . . . . . .                                                          13
NON-IFRS ADJUSTED NET PROFIT ATTRIBUTABLE TO OWNERS OF THE COMPANY . . .                                                                16
DEFINITIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     17
GLOSSARY OF TECHNICAL TERMS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                         25
RISK FACTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .        31
TERMS AND CONDITIONS OF THE SERIES 1 BONDS . . . . . . . . . . . . . . . . . . . . . . . . . . . .                                      66
TERMS AND CONDITIONS OF THE SERIES 2 BONDS . . . . . . . . . . . . . . . . . . . . . . . . . . . .                                     108
SUMMARY OF PROVISIONS RELATING TO THE BONDS IN GLOBAL FORM . . . . . . . . . .                                                         150
USE OF PROCEEDS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .          152
CAPITALIZATION AND INDEBTEDNESS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                          153
DESCRIPTION OF THE GROUP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                   154
RECENT DEVELOPMENT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                181
DIRECTORS, SUPERVISORS AND SENIOR MANAGEMENT . . . . . . . . . . . . . . . . . . . . . . . .                                           182
MARKET PRICE INFORMATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                     190
EXCHANGE RATE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .          191
DIVIDENDS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .    193

SUBSTANTIAL SHAREHOLDERS’ AND DIRECTORS’ AND CHIEF EXECUTIVES’
  INTERESTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .    194
DESCRIPTION OF THE SHARES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                    201
TAXATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   202
SUBSCRIPTION AND SALE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                206
GENERAL INFORMATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .                210




                                                                     vii
                                               SUMMARY

The summary below is only intended to provide a limited overview of information described in more detail
elsewhere in this Offering Circular. As it is a summary, it does not contain all of the information that may
be important to investors and terms defined elsewhere in this Offering Circular shall have the same
meanings when used in this summary. Prospective investors should therefore read this Offering Circular in
its entirety, including the section entitled “Risk Factors”, to determine whether an investment in the Bonds
is appropriate.

Overview

Pharmaron is a leading fully-integrated pharmaceutical R&D service platform with global operations to
accelerate drug innovation for our customers. The Company is one of the top three drug discovery service
providers globally in terms of total revenue in 2020, according to Frost & Sullivan. The Company has
established our leadership in drug discovery, pre-clinical and early clinical-stage development, while it has
also been expanding its capabilities downstream to late clinical-stage development and commercial
manufacturing. In expanding along the pharmaceutical R&D process, the Company has established
expertise in all major R&D functions to deliver key milestones in each R&D stage, thereby enabling its
customers to conduct their R&D programs in an accelerated manner.

As a leading drug discovery pharmaceutical R&D service provider, the Company accumulated profound
scientific insights on molecules and built customers’ trust since early stage of their innovative drug research
and development. As such, when its customers further develop their R&D programs to the preclinical and
clinical development stages, the Company is in the unique position to become their partner of choice in their
subsequent R&D programs. In order to meet the customers’ needs for R&D services, the Company naturally
expanded its service offerings into clinical development and CMC (small molecule CDMO) services and
became a fully integrated service provider. In 2019 and 2020, the Company further expanded its service
offerings into biologics services and strengthened our technology platforms through strategic acquisitions
in the U.S. and the U.K. the Company’s integrated solutions and profound understanding of customers’
needs further enable it to provide customized pharmaceutical R&D services beyond service and geographic
boundaries.

The Company operates globally through its 16 laboratories, clinical and manufacturing facilities in China,
the U.S. and the U.K., of which eight operating facilities are located overseas. The Company’s profound
experience in global pharmaceutical R&D, together with its global operations and world-class technical
capabilities, allows it to offer its customers a unique proposition that combines the Company’s technical
expertise in different geographic location and efficient services with seamless integration. In addition, the
Company’s experience to conduct regulatory filings in various jurisdictions and its total solution approach
enable its customers to file investigational new drug (IND) applications for their drug candidates in China,
the U.S. or Europe in parallel and better support them when they enter into the overseas markets, which
provides greater flexibility and efficiency in their business development strategies. In 2020, the Company
submitted 58 IND applications for its pharmaceutical and biotech customers in China, among which 46 were
IND applications targeting multiple jurisdictions (include China, the U.S. and EU), which demonstrated the
advantage of and strong demand for its total solution approach.

The Company has a large, diverse and loyal customer base. As of December 31, 2020, it had an aggregate
of over 1,500 customers, which included all of the top 20 global pharmaceutical companies that contributed
to 23.7% of its revenue in 2020, and many reputable biotech companies. The Company is also a partner of
choice of fast-growing start-ups and virtual biotech companies. Its loyal and growing customer base allows
it to expand to new services along the drug discovery and development processes, as its existing customers’
projects progress further. In addition, the comprehensive service offerings of the Company enable it to
cross-sell services of different scientific functions to meet the customers’ evolving needs. For example, over
80% of the revenue from its biologics services in 2020 was generated from its existing customers who used
the Company’s laboratory services for small molecule drugs, and nearly 80% of the revenue from the
Company’s CMC (small molecule CDMO) services in 2020 was generated from existing customers using
its laboratory services. The strong execution capabilities of the Company and quality customer services are
widely recognized by our customers, which increases its customer stickiness and enables it to develop long
term cooperation/partner relationship with them.


                                                       1
The Company is devoted to providing customers with world-class pharmaceutical R&D services. Since
inception, the Company has put great emphasis on technology and innovation to fuel the constant growth
of its business and satisfy the evolving R&D needs of its customers. It develops new technologies through
multiple measures such as internal research and development, collaboration with academic and professional
institutions, customer collaboration and acquisitions. In recent years, the Company has been strategically
developing new technologies and capabilities in chemistry and bioscience areas, and committed to further
strengthening of the integrated services platform.

Led by Dr. LOU, the chairman and chief executive officer of the Company, the highly skilled and
experienced management team with diverse expertise and extensive knowledge has significantly
contributed to the growth of the Company’s institutional knowledge base. In addition, their international
background, together with their deep understanding of the China market and the open and embracing
corporate culture of the Group, provide it with global expansion capabilities. In addition, the management
team of the Company has established a highly experienced talent pool with strong execution capabilities.
As of December 31, 2020, it had over 9,800 scientists and research technicians in China, the U.K. and the
U.S. The Company is committed to its corporate philosophy of “Employee First and Customer Centric”
which puts strong emphasis on employee training and improves all mechanisms so as to integrate their
career development into the Company’s overall development strategy. In order to develop and train its
talents, the Company provides continuous training programs to its employees through “Pharmaron
College,” visiting scholar programs and various symposiums, forums and lectureship. Through these
initiatives, its team members can acquire updates on the most advanced technology and techniques, thereby
supporting the Company’s continued and sustainable expansion with a cohesive, vibrant and stable
mid-level management team.

The Company experienced significant growth during the three years ended December 31, 2020. Its revenue
increased significantly from RMB2,908.1 million in 2018 to RMB3,757.2 million in 2019 and further to
RMB5,133.6 million in 2020, representing a CAGR of 32.9%. Its net profit increased significantly from
RMB335.8 million in 2018 to RMB530.7 million in 2019 and further to RMB1,147.0 million in 2020,
representing a CAGR of 84.8%.

Competitive Strengths

The Group believes the following strengths have contributed to its success and differentiate the Group from
its competitors:

     Leading fully-integrated pharmaceutical R&D services platform with strong capabilities and
     comprehensive service offerings across the globe;

     Global operations, profound experience in pharmaceutical R&D and state-of-the-art technologies to
     provide customized solutions;

     Committed to utilizing innovative technologies to meet evolving R&D needs and increase efficiency;

     Dedicated, stable and visionary management teams, experienced talent pools with progressive
     corporate culture;

     Reputable, loyal and expanding customer base that contributes to our sustainable growth and business
     collaboration; and

     Insight into industry trends and well positioned to capture growth opportunities arising from industry
     evolution.




                                                    2
Growth Strategies

The Group aims to solidify its leading position as a global fully-integrated pharmaceutical R&D service
platform. In order to achieve this goal, The Group has been executing and will continue to execute the
following key strategies:

     Continue to maintain our leading position in pharmaceutical R&D services of small molecule
     innovative drugs and further expand our development service offerings;

     Accelerate the buildup of biologics and CGT services platform;

     Deepen collaborations with existing customers and broaden customer base;

     Continue to enlarge our talent pool and enhance our operation efficiency to support long-term and
     sustainable growth.

Risk Factors

The Group’s operations and the offering of the Bonds involve certain risks and uncertainties, some of which
are beyond the Company’s control and may affect your decision to invest in the Bonds and/or the value of
your investment. Please refer to the section headed “Risk Factors” in this Offering Circular. You should read
this entire section and this Offering Circular before you decide to invest.

The primary risks and uncertainties that may affect the Group’s business, results of operations, financial
condition and prospects include: (i) risks related to the Group’s business and industry; (ii) risks relating to
conducting business in China; and (iii) risks relating to the Bonds, the Shares and the Offering. Moreover,
the Group may also be subject to other risks and uncertainties that are not foreseen or known to the Group
at this time. The occurrence of any of the risk factors disclosed in this Offering Circular may have a material
adverse effect on the Group’s business, results of operations, financial condition and prospects.

Recent Development

In February 2021, Pharmaron Biologics (UK) Holdings Limited and Pharmaron (Hong Kong) International
Limited (both are our wholly-owned subsidiaries) entered into a sale and purchase Agreement with AGN
Sundry LLC to acquire 100% equity interest of Allergan Biologics Limited (“ABL”), at an estimated cash
consideration of US$120,000,000 (equivalent to RMB776,556,000). ABL (an indirect subsidiary of AbbVie
Inc., a company listed on the New York Stock Exchange) is an in-house R&D center of AbbVie Inc. for
biologics and other advanced therapeutics. It operates a manufacturing facility in Liverpool, U.K., which
is one of the most advanced research and development and clinical manufacturing facilities in the area. The
acquisition was completed in April 2021, and we expect the newly acquired facilities will be highly
synergistic to Absorption Systems, one of our operating subsidiaries in the U.S., for building an integrated
CGT services platform.

In addition, we continued to develop the discovery biologics service capabilities and accelerated the
establishment of our biologics CDMO service platform. In early 2020, we started the construction of
approximately 70,000 sq.m. of our biologics product development and manufacturing facility at our Ningbo
Hangzhou Bay service center II phase I site, and which is expected to start internal installation in June 2021
and become operational for GMP production in the second half of 2022.

The Company proposed to repurchase and cancel 193,024 Restricted A Shares granted under the A Share
Incentive Scheme due to the resignation of the three grantees of such Restricted A Shares in accordance with
the provisions of the A Share Incentive Scheme, and the reduction of registered capital from
RMB794,387,462 to RMB794,194,438 and the decrease of number of issued shares of the Company from
794,387,462 shares to 794,194,438 shares, which were approved by the Company’s shareholders at the
annual general meeting dated May 28, 2021.


                                                       3
Subject to the required approvals by the Board and the shareholders of the Company, respectively, the
Company plans to adopt the Pharmaron 2021 A Restricted Share Incentive Scheme (the “2021 Share
Incentive Scheme”) and issue up to 774,200 A Shares of the Company under the 2021 Share Incentive
Scheme (the “Restricted A Shares”), which represents 0.0975% of the Company’s share capital as of the
date hereof. It is expected that all Restricted A Shares will be granted to eligible employees of the Company
upon the respective approvals by the Board and the shareholders of the Company, and none of the Restricted
A Shares will be reserved for future option grants. The Restricted A Shares have a vesting period of four
years, with 25% of the awards to be released on the first, second, third and fourth anniversary date of the
A Shares registration date with respect to such Restricted A Shares, respectively, and upon relevant annual
performance conditions being met.




                                                     4
                                                         THE OFFERING

The following summary contains basic information about the Bonds and is not intended to be complete. It
does not contain all the information that is important to investors. For a more complete description of the
Bonds, please refer to the section of this Offering Circular entitled “Terms and Conditions of the Series 1
Bonds” and “Terms and Conditions of the Series 2 Bonds.” Phrases used in this summary and not otherwise
defined shall have the meaning given to them in the section entitled “Terms and Conditions of the Series
1 Bonds” and “Terms and Conditions of the Series 2 Bonds.”

Issuer .............................................   Pharmaron Beijing Co., Ltd. (            (    )
                                                         ).

Series 1 Bonds ...............................         US$300,000,000 zero coupon convertible bonds due 2026
                                                       convertible at the option of the holder thereof into fully paid
                                                       ordinary H Shares of the Issuer of par value RMB1.00 each at the
                                                       initial conversion price of HK$250.75 per Share.

Series 2 Bonds ...............................         RMB1,916,000,000 U.S. dollar settled zero coupon convertible
                                                       bonds due 2026 convertible at the option of the holder thereof into
                                                       fully paid ordinary H Shares of the Issuer of par value RMB1.00
                                                       each at the initial conversion price of HK$229.50 per Share.

                                                       The issue of the Bonds was authorized by the Company pursuant to
                                                       the general mandate granted to the Board by the Shareholders at the
                                                       annual general meeting of the Company held on May 28, 2021 and
                                                       the resolutions of the Board of Directors of the Company passed on
                                                       June 4, 2021.

A Share(s) ......................................      Domestic share(s) with a nominal value of RMB1.00 each in the
                                                       share capital of the Issuer, which are listed for trading on the
                                                       Shenzhen Stock Exchange and traded in Renminbi (Stock Code:
                                                       300759.SZ).

H Share(s)......................................       Overseas-listed foreign share(s) with a nominal value of RMB1.00
                                                       each in the share capital of the Issuer, which are listed on the Hong
                                                       Kong Stock Exchange and traded in Hong Kong dollars (Stock Code
                                                       3759).

Issue Price .....................................      100 per cent. of the principal amount for the Series 1 Bonds and 100
                                                       per cent. of the principal amount of the Series 2 Bonds.

Form and Denomination of                               The Series 1 Bonds will be issued in registered form in the specified
  Bonds ..........................................     denomination of US$200,000 each and integral multiples of
                                                       US$100,000 in excess thereof and the Series 2 Bonds will be issued
                                                       in registered form in the specified denomination of RMB2,000,000
                                                       each and integral multiples of RMB1,000,000 in excess thereof.

Interest...........................................    The Bonds are zero coupon and do not bear interest.

Issue Date ......................................      Series 1 Bonds: June 18, 2021

                                                       Series 2 Bonds: June 18, 2021

Maturity Date ................................         Series 1 Bonds: June 18, 2026

                                                       Series 2 Bonds: June 18, 2026



                                                                     5
Negative Pledge .............................        So long as any Bond remains outstanding, the Issuer will not create
                                                     or permit to subsist, and the Issuer will procure that no Subsidiary
                                                     will create, or have outstanding, any mortgage, charge, pledge, lien
                                                     or other form of encumbrance or security interest upon the whole or
                                                     any part of its undertaking, assets or revenues (including any
                                                     uncalled capital), present or future, to secure any Investment
                                                     Securities or to secure any guarantee of or indemnity in respect of
                                                     any Investment Securities unless, at the same time or prior thereto
                                                     according to the Bonds the same security as is created or subsisting
                                                     to secure any such Investment Securities, guarantee or indemnity or
                                                     such other security as either (i) the Trustee shall in its absolute
                                                     discretion deem not materially less beneficial to the interests of the
                                                     Bondholders or (ii) shall be approved by an Extraordinary
                                                     Resolution of the Bondholders. See “Terms and Conditions of the
                                                     Series 1 Bonds – Negative Pledge” and “Terms and Conditions of
                                                     the Series 2 Bonds – Negative Pledge”.

Status of the Bonds .......................          The Bonds will constitute direct, senior, unconditional,
                                                     unsubordinated and (subject to Condition 3.1 (Negative Pledge) of
                                                     the Terms and Conditions) unsecured obligations of the Issuer and
                                                     shall rank pari passu and without any preference or priority among
                                                     themselves. The payment obligations of the Issuer under the Bonds
                                                     shall, save for such exceptions as may be provided by mandatory
                                                     provisions of applicable law and subject to Condition 3.1 (Negative
                                                     Pledge) of the Terms and Conditions, at all times rank at least
                                                     equally with all of its other present and future unsecured and
                                                     unsubordinated obligations. See “Terms and Conditions of the Series
                                                     1 Bonds – Status” and “Terms and Conditions of the Series 2 Bonds
                                                     – Status”.

Taxation .........................................   All payments made by or on behalf of the Issuer in respect of the
                                                     Bonds will be made free from any restriction or condition and will
                                                     be made without deduction or withholding for or on account of any
                                                     present or future taxes, duties, assessments or governmental charges
                                                     of whatever nature imposed, levied, collected, withheld or assessed
                                                     by or on behalf of the PRC or Hong Kong or any authority thereof
                                                     or therein having power to tax, unless deduction or withholding of
                                                     such taxes, duties, assessments or governmental charges is
                                                     compelled by law. If the Issuer is required to make a deduction or
                                                     withholding in respect of PRC tax in excess of the aggregate rate
                                                     applicable on June 8, 2021, or any Hong Kong deduction or
                                                     withholding is required, in such event that the Issuer shall pay such
                                                     additional amounts as will result in receipt by the Bondholders of
                                                     such amounts as would have been received by them had no such
                                                     withholding or deduction been required, except in circumstances
                                                     specified in Condition 8 (Taxation) of the Terms and Conditions.
                                                     See “Terms and Conditions of the Series 1 Bonds – Taxation” and
                                                     “Terms and Conditions of the Series 2 Bonds – Taxation”.




                                                                   6
Conversion Right and Period .......            Subject as provided in the Terms and Conditions, each Bond shall
                                               entitle the holder to convert such Bond into H Shares (the
                                               “Conversion Right”). Subject to and upon compliance with the
                                               Terms and Conditions, the Conversion Right attaching to any Bond
                                               may be exercised, at the option of the Bondholder, at any time on or
                                               after 41st day after the Issue Date up to the close of business (at the
                                               place where the Certificate evidencing such Bond is deposited for
                                               conversion) on the date falling 10 working days prior to the Maturity
                                               Date, or if such Bond shall have been called for redemption by the
                                               Issuer before the Maturity Date, then up to and including the close
                                               of business (at the place aforesaid) on a date no later than 10
                                               working days (at the place aforesaid) prior to the date fixed for
                                               redemption thereof provided that (i) no Conversion Right may be
                                               exercised in respect of a Bond where the holder shall have exercised
                                               its right to require the Issuer to redeem or repurchase such Bond
                                               pursuant to Condition 7.4 (Redemption at the Option of the
                                               Bondholders) or Condition 7.5 (Redemption for Relevant Events) of
                                               the Terms and Conditions or during a Restricted Conversion Period
                                               (both dates inclusive) and (ii) the Conversion Right is exercised
                                               subject to any applicable fiscal or other laws or regulations or as
                                               hereafter provided in the Terms and Conditions (the “Conversion
                                               Period”). See “Terms and Conditions of the Series 1 Bonds –
                                               Conversion Right” and “Terms and Conditions of the Series 2 Bonds
                                               – Conversion Right”.

Conversion Price ...........................   The price at which H Shares will be issued upon conversion will
                                               initially be HK$250.75 per H Share with respect to the Series 1
                                               Bonds and HK$229.50 per H Share with respect to the Series 2
                                               Bonds, but will be subject to adjustments for, among other things,
                                               consolidation, subdivision or re-classification, capitalization of
                                               profits or reserves, capital distributions, rights issues of Shares or
                                               options over Shares, rights issues of other securities, issues at less
                                               than current market price and certain other dilutive events. See
                                               “Terms and Conditions of the Series 1 Bonds – Conversion –
                                               Adjustments to Conversion Price” and “Terms and Conditions of the
                                               Series 2 Bonds – Conversion – Adjustments to Conversion Price”.

Redemption at Maturity ...............         Unless previously redeemed, converted or purchased and cancelled
                                               as provided in the Terms and Conditions, the Issuer will redeem each
                                               Series 1 Bond at 100.0 per cent. of its outstanding principal amount
                                               on the Maturity Date and each Series 2 Bond at the U.S. Dollar
                                               Equivalent of 107.76% of its principal amount on the Maturity Date.
                                               See “Terms and Conditions of the Series 1 Bonds – Redemption,
                                               Purchase and Cancellation – Maturity” and “Terms and Conditions
                                               of the Series 2 Bonds – Redemption, Purchase and Cancellation –
                                               Maturity”.




                                                             7
Redemption for Taxation                               The Bonds may be redeemed, at the option of the Issuer in whole,
  Reasons.......................................      but not in part, at any time, on giving not less than 30 nor more than
                                                      60 days’ notice to the Trustee, the Principal Agent and the
                                                      Bondholders (which notice shall be irrevocable), at, in respect of the
                                                      Series 1 Bonds, the principal amount, and in respect of the Series 2
                                                      Bonds, the U.S. Dollar Equivalent of the Early Redemption Amount
                                                      as of the relevant redemption date, if the Issuer satisfies the Trustee
                                                      immediately prior to the giving of such notice that (i) the Issuer has
                                                      or will become obliged to pay Additional Tax Amounts as provided
                                                      or referred to in Condition 8 (Taxation) of the Terms and Conditions
                                                      as a result of any change in, or amendment to, the laws or
                                                      regulations of the PRC or Hong Kong or any political subdivision or
                                                      any authority thereof or therein having power to tax, or any change
                                                      in the general application or official interpretation of such laws or
                                                      regulations, which change or amendment becomes effective on or
                                                      after June 8, 2021, and (ii) such obligation cannot be avoided by the
                                                      Issuer taking reasonable measures available to it, provided that no
                                                      such notice of redemption shall be given earlier than 90 days prior
                                                      to the earliest date on which the Issuer would be obliged to pay such
                                                      Additional Tax Amounts were a payment in respect of the Bonds
                                                      then due. If the Issuer exercises its tax redemption right, each
                                                      Bondholder shall have the right to elect that its Bonds shall not be
                                                      redeemed. Upon a Bondholder electing not to have its Bonds
                                                      redeemed in such circumstances, any payments due after the
                                                      relevant date of redemption shall be made subject to any deduction
                                                      or withholding of any taxation required to be deducted or withheld.
                                                      See “Terms and Conditions of the Series 1 Bonds – Redemption,
                                                      Purchase and Cancellation – Redemption for Taxation” and “Terms
                                                      and Conditions of the Series 2 Bonds – Redemption, Purchase and
                                                      Cancellation – Redemption for Taxation Reasons”.

Redemption at the Option of the                       On giving not less than 30 nor more than 60 days’ notice to the
  Issuer ..........................................   Bondholders, the Trustee and the Principal Agent (which notice will
                                                      be irrevocable), the Bonds may be redeemed by the Issuer in whole,
                                                      but not in part, on the date specified in the Optional Redemption
                                                      Notice at, in respect of the Series 1 Bonds, the principal amount, and
                                                      in respect of the Series 2 Bonds, the U.S. Dollar Equivalent of the
                                                      Early Redemption Amount, (i) in respect of the Series 1 Bonds only
                                                      at any time after June 18, 2024 but prior to the Maturity Date,
                                                      subject to certain conditions as specified in the Terms and
                                                      Conditions, or (ii) in respect of both Series at any time if, the
                                                      aggregate principal amount of the Bonds outstanding is less than 10
                                                      per cent. of the aggregate principal amount originally issued (which
                                                      shall for this purpose include any further bonds issued in accordance
                                                      with Condition 15 (Further Issues) of the Terms and Conditions and
                                                      consolidated and forming a single series therewith). See “Terms and
                                                      Conditions of the Series 1 Bonds – Redemption, Purchase and
                                                      Cancellation – Redemption at the Option of the Issuer” and “Terms
                                                      and Conditions of the Series 2 Bonds – Redemption, Purchase and
                                                      Cancellation – Redemption at the Option of the Issuer”.




                                                                    8
Redemption at the Option of the                 The Issuer will, at the option of the holder of any Bond, redeem all
  Bondholders ...............................   or some only of that holder’s Bonds on June 18, 2024 (the “Put
                                                Option Date”) at, in respect of the Series 1 Bonds, 100.0 per cent.,
                                                and in respect of the Series 2 Bonds, the U.S. Dollar Equivalent of
                                                104.59 per cent. of their outstanding principal amount. See “Terms
                                                and Conditions of the Series 1 Bonds – Redemption, Purchase and
                                                Cancellation – Redemption at the Option of the Bondholders” and
                                                “Terms and Conditions of the Series 2 Bonds – Redemption,
                                                Purchase and Cancellation – Redemption at the Option of the
                                                Bondholders”.

Redemption for Relevant Events..                Following the occurrence of a Relevant Event, the holder of each
                                                Bond will have the right at such holder’s option, to require the Issuer
                                                to redeem all but not some only of such holder’s Bonds on the
                                                Relevant Event Put Date at, in respect of the Series 1 Bonds, their
                                                principal amount, and in respect of the Series 2 Bonds, the U.S.
                                                Dollar Equivalent of the Early Redemption Amount as of the
                                                Relevant Event Put Date.

                                                A “Relevant Event” occurs when:

                                                (i)    there is a Change of Control (as defined in the Terms and
                                                       Conditions) in the Issuer;

                                                (ii)   when the H Shares cease to be listed or admitted to trading on
                                                       the Hong Kong Stock Exchange; or

                                                (iii) the suspension in trading of the H Shares for a period of 30
                                                      consecutive H Share Stock Exchange Business Days.

                                                See “Terms and Conditions of the Series 1 Bonds – Redemption,
                                                Purchase and Cancellation – Redemption for Relevant Events” and
                                                “Terms and Conditions of the Series 2 Bonds – Redemption,
                                                Purchase and Cancellation – Redemption for Relevant Events”.




                                                               9
Issuer Lock-up...............................     The Issuer has agreed in the Subscription Agreement that neither the
                                                  Issuer nor any person acting on its behalf will (a) issue, offer, sell,
                                                  pledge, encumber, contract to sell or otherwise dispose of or grant
                                                  options, issue warrants or offer rights entitling persons to subscribe
                                                  or purchase any interest in any Shares or securities of the same class
                                                  as the Bonds or the Shares or any securities convertible into,
                                                  exchangeable for or which carry rights to subscribe or purchase the
                                                  Bonds, the Shares or securities of the same class as the Bonds, the
                                                  Shares or other instruments representing interests in the Bonds, the
                                                  Shares or other securities of the same class as them, (b) enter into
                                                  any swap or other agreement that transfers, in whole or in part, any
                                                  of the economic consequences of the ownership of the Shares, (c)
                                                  enter into any transaction with the same economic effect as, or
                                                  which is designed to, or which may reasonably be expected to result
                                                  in, or agree to do, any of the foregoing, whether any such transaction
                                                  of the kind described in (a), (b) or (c) is to be settled by delivery of
                                                  Shares or other securities, in cash or otherwise or (d) announce or
                                                  otherwise make public an intention to do any of the foregoing, in
                                                  any such case without the prior written consent of the Managers
                                                  between the date hereof and the date which is 90 days after the Issue
                                                  Date (both dates inclusive); except for (i) the Bonds and the New
                                                  Shares issued on conversion of the Bonds, or (ii) any Shares or other
                                                  securities (including rights or options) which are issued, offered,
                                                  exercised, allotted, appropriated, modified or granted to, or for the
                                                  benefit of employees (including directors) of the Issuer or any of its
                                                  subsidiaries pursuant to any employee share scheme or plan.

Cross Default .................................   The Bonds may be accelerated in the event of, (i) any other present
                                                  or future indebtedness of the Issuer or any of its Subsidiaries for or
                                                  in respect of moneys borrowed or raised becomes (or becomes
                                                  capable of being declared) due and payable prior to its stated
                                                  maturity by reason of any actual or potential default, event of
                                                  default or the like (howsoever described), or (ii) any such
                                                  indebtedness is not paid when due or, as the case may be, within any
                                                  applicable grace period, or (iii) the Issuer or any of its Subsidiaries
                                                  fails to pay when due any amount payable by it under any present or
                                                  future guarantee for, or indemnity in respect of, any present or future
                                                  indebtedness in respect of moneys borrowed or raised, provided that
                                                  the aggregate amount of the relevant indebtedness, guarantees and
                                                  indemnities in respect of which one or more of the events mentioned
                                                  above have occurred equals or exceeds US$25,000,000 or its
                                                  equivalent in any other currency. See “Terms and Conditions of the
                                                  Series 1 Bonds – Events of Default” and “Terms and Conditions of
                                                  the Series 2 Bonds – Events of Default”.




                                                               10
Further Issues................................        The Issuer may from time to time, without the consent of the
                                                      Bondholders, create and issue further bonds having the same terms
                                                      and conditions as the Bonds in all respects (or in all respects except
                                                      for the issue date, the first payment of interest thereon and the
                                                      timing for complying with the requirements set out in the Terms and
                                                      Conditions in relation to the NDRC Post-Issuance Filing and the
                                                      Foreign Debt Registration) and so that such further issue shall be
                                                      consolidated and form a single series with the Bonds. See “Terms
                                                      and Conditions of the Series 1 Bonds – Further Issues” and “Terms
                                                      and Conditions of the Series 2 Bonds – Further Issues”.

Clearing Systems ...........................          The Bonds will be cleared through Euroclear and Clearstream.
                                                      Euroclear and Clearstream each hold securities for their customers
                                                      and facilitate the clearance and settlement of securities transactions
                                                      by electronic book entry transfer between their respective account
                                                      holders.

Governing Law ..............................          The Bonds and any non-contractual obligations arising out of or in
                                                      connection with the Bonds will be governed by, and construed in
                                                      accordance with English law.

Legal Entity Identifier ..................            300300JYXHGVS5SNGG54

Listing and Trading of the                            Application will be made to the Hong Kong Stock Exchange for the
  Bonds ..........................................    listing of, and permission to deal in, the Bonds to Professional
                                                      Investors only and formal permission is expected to become
                                                      effective on June 21, 2021.

Listing of Shares ...........................         The Shares are listed on the Hong Kong Stock Exchange.
                                                      Application will be made to the Hong Kong Stock Exchange for the
                                                      listing of the Shares issuable upon conversion of the Bonds (the
                                                      “New Shares”).

Trustee ...........................................   Citicorp International Limited

Principal Agent and Registrar .....                   Citibank, N.A., London Branch

Calculation Agent ..........................          Conv-Ex Advisors Limited

Selling Restrictions .......................          There are restrictions on the offer, sale and transfer of the Bonds in,
                                                      among others, the United States, the United Kingdom, EEA, the
                                                      PRC, Hong Kong, Singapore, Japan and the Cayman Islands. For a
                                                      description of the selling restrictions on offers, sales and deliveries
                                                      of the Bonds, see “Subscription and Sale”.




                                                                   11
Global Certificate..........................           For as long as the Bonds are represented by the respective Global
                                                       Certificates and the respective Global Certificates are deposited
                                                       with a common depositary for Euroclear and Clearstream, payments
                                                       of principal and premium (if any) in respect of the Bonds
                                                       represented by the respective Global Certificates will be made
                                                       without presentation or if no further payment falls to be made in
                                                       respect of the Bonds, against presentation and surrender of the
                                                       respective Global Certificates to or to the order of the Principal
                                                       Agent or such other Paying Agent as shall have been notified to
                                                       Bondholders for such purpose. The Bonds which are represented by
                                                       the respective Global Certificates will be transferable only in
                                                       accordance with the rules and procedures for the time being of the
                                                       relevant Clearing System.

Use of Proceeds .............................          See “Use of Proceeds”.

Risk Factors ..................................        For a discussion of certain factors that should be considered in
                                                       evaluating an investment in the Bonds, see “Risk Factors”.

ISIN................................................   Series 1 Bonds: XS2352395748

                                                       Series 2 Bonds: XS2353011724

Common Code ...............................            Series 1 Bonds: 235239574

                                                       Series 2 Bonds: 235301172




                                                                    12
SELECTED CONSOLIDATED FINANCIAL INFORMATION OF THE COMPANY

The following tables set forth the selected consolidated financial and other operating information of the
Company as of and for the periods indicated.

The selected consolidated financial statements of the Company as of and for the years ended December 31,
2018, 2019 and 2020 set forth below have been extracted from the Company’s consolidated financial
statements as of and for the years ended December 31, 2019 and 2020, which have been audited by Ernst
& Young, Certified Public Accountants, the independent auditor of the Company accountant and are
incorporated by reference in this Offering Circular.

The audited consolidated financial statements of the Company as of and for the years ended December 31,
2019 and 2020 have been prepared and presented in accordance with the IFRSs.

You should read the selected consolidated financial statements of the Company set forth below in
conjunction with the consolidated financial statements of the Company. In evaluating the business of the
Group, you should carefully consider the information provided in the section headed “Risk Factors” in this
Offering Circular.

Consolidated Statement of Profit or Loss

                                                                                              For the year ended December 31,
                                                                                          2020             2019             2018
                                                                                        RMB’000         RMB’000         RMB’000
Revenue ............................................................................      5,133,597       3,757,160        2,908,123
Cost of sales ......................................................................     (3,217,484)     (2,425,459)      (1,960,073)
Gross profit ......................................................................      1,916,113        1,331,701          948,050
Other income and gains .....................................................               493,006           70,153           53,759
Other expenses ..................................................................         (143,814)         (11,761)          (6,767)
Selling and distribution expenses ......................................                   (92,643)         (72,989)         (54,647)
Administrative expenses ....................................................              (684,705)        (526,408)        (420,456)
Research and development costs .......................................                    (105,345)         (62,872)         (31,611)
Impairment losses on financial and contract assets, net of
  reversal ..........................................................................      (14,823)          (5,495)             (8,886)
Finance costs .....................................................................        (23,854)         (82,476)            (82,366)
Share of losses of associates .............................................                (24,565)          (7,303)             (1,132)
Profit before tax...............................................................         1,319,370          632,550             395,944
Income tax expense ...........................................................            (172,378)        (101,878)            (60,101)
Profit for the year............................................................          1,146,992          530,672             335,843
Attributable to:
Owners of the parent .........................................................           1,172,383          547,190             336,042
Non-controlling interests ...................................................              (25,391)         (16,518)               (199)
                                                                                         1,146,992          530,672             335,843
Earnings Per Share Attributable to Ordinary Equity
  Holders of the Parent
Basic
For profit for the year .......................................................         RMB1.4825      RMB0.8284         RMB0.5689
Diluted
For profit for the year .......................................................         RMB1.4781      RMB0.8282         RMB0.5689




                                                                           13
Consolidated Statement of Comprehensive Income

                                                                                           For the year ended December 31,
                                                                                        2020            2019             2018
                                                                                      RMB’000        RMB’000         RMB’000
Profit for the year............................................................        1,146,992         530,672             335,843
Other Comprehensive Income
Other comprehensive income/(loss) that may be
  reclassified to profit or loss in subsequent periods:
Exchange difference on translation of foreign operations..                               (40,578)         11,847              (7,376)
Net other comprehensive income that may be
  reclassified to profit or loss in subsequent periods....                               (40,578)         11,847              (7,376)
Other comprehensive income/(loss) for the year,
  net of tax ......................................................................      (40,578)         11,847              (7,376)
Total comprehensive income for the year ......................                         1,106,414         542,519             328,467
Attributable to:
  Owners of the parent .....................................................           1,131,835         558,937             328,094
  Non-controlling interests................................................              (25,421)        (16,418)                373
                                                                                       1,106,414         542,519             328,467




                                                                         14
Consolidated Statement of Financial Position

                                                                                             For the year ended December 31,
                                                                                          2020            2019             2018
                                                                                        RMB’000        RMB’000         RMB’000
Non-Current Assets
Property, plant and equipment ...........................................                3,841,445       2,973,354        2,677,138
Right-of-use assets ............................................................           567,630         498,989          498,921
Investment properties ........................................................              43,889          46,013           44,428
Goodwill............................................................................     1,166,172         203,286          139,917
Other intangible assets ......................................................             189,976          35,352           13,900
Investments in associates...................................................               280,474         131,246           28,868
Equity investments at fair value through profit or loss .....                              121,230          59,054           24,267
Deferred tax assets ............................................................             8,436           6,372            8,446
Other non-current assets ....................................................              149,162          36,921           90,087
Total non-current assets .....................................................           6,368,414       3,990,587        3,525,972
Current Assets
Inventories .........................................................................      128,757          97,050              70,148
Contract costs ....................................................................        152,860          60,347              50,313
Trade receivables...............................................................         1,076,614         857,069             603,993
Contract assets...................................................................         133,764          89,105              51,078
Prepayments, other receivables and other assets ...............                            196,020         197,576             179,451
Financial assets at fair value through profit or loss ..........                           825,312         169,762                   –
Derivative financial instruments ........................................                   84,698          13,689                 413
Pledged deposits ................................................................            7,263          17,634              13,476
Cash and cash equivalents .................................................              2,935,090       4,442,218             307,235
Total current assets ............................................................        5,540,378       5,944,450        1,276,107
Current Liabilities
Interest-bearing bank and other borrowings ......................                         386,146          300,654             534,968
Trade payables...................................................................         191,497          117,978             108,220
Other payables and accruals ..............................................                819,313          486,702             403,955
Contract liabilities .............................................................        473,289          271,547             187,156
Lease liabilities .................................................................        83,925           64,150              60,336
Tax payable .......................................................................        27,620           28,649              13,413
Total current liabilities ......................................................         1,981,790       1,269,680        1,308,048
Net Current Assets/Liabilities .........................................                 3,558,588       4,674,770          (31,941)
Total Assets Less Current Liabilities..............................                      9,927,002       8,665,357        3,494,031
Non-Current Liabilities
Interest-bearing bank and other borrowings ......................                         394,811          543,791             898,999
Deferred tax liabilities.......................................................           106,906           40,782              22,306
Financial liabilities at fair value through profit or loss .....                          146,810                –                  –
Deferred income ................................................................          158,128          111,606             100,989
Lease liabilities .................................................................       186,608          131,160             145,166
Total non-current liabilities ...............................................             993,263          827,339        1,167,460
Net Assets .........................................................................     8,933,739       7,838,018        2,326,571
Equity
Share Capital .....................................................................        794,387         794,387          590,664
Treasury shares..................................................................          (45,475)        (72,781)               –
Reserves ............................................................................    8,121,407       7,045,457        1,722,916
Equity attributable to owners of the parent ..................                           8,870,319       7,767,063        2,313,580
Non-controlling interests ...................................................               63,420          70,955           12,991
Total equity .......................................................................     8,933,739       7,838,018        2,326,571




                                                                           15
NON-IFRS ADJUSTED NET PROFIT ATTRIBUTABLE TO OWNERS OF THE COMPANY

To supplement our consolidated financial statements which are presented in accordance with the IFRS, the
Company use adjusted net profit attributable to owners as an additional financial measure. The Company
defines adjusted net profit attributable to owners as profit/(loss) for the year before certain expenses and
depreciation and amortization as set out in the table below. Adjusted net profit attributable to owners is not
an alternative to: (1) profit before income tax or profit for the year (as determined in accordance with IFRS)
as a measure of our operating performance, (2) cash flows from operating, investing and financing activities
as a measure of our ability to meet our cash needs, or (3) any other measures of performance or liquidity.

The Company believes that the adjusted non-IFRS net profit attributable to owners of the Company is useful
for understanding and assessing underlying business performance and operating trends, and that the
Company’s management and investors may benefit from referring to these adjusted non-IFRS financial
measures in assessing the Group’s financial performance by eliminating the impact of certain unusual and
non-recurring items that the Group does not consider indicative of the performance of the Group’s business.
However, the presentation of the adjusted non-IFRS net profit attributable to owners of the Company is not
intended to be considered in isolation or as a substitute for the financial information prepared and presented
in accordance with the IFRS. The adjusted non-IFRS net profit attributable to owners of the Company does
not have a standardized definition prescribed under the IFRS and therefore may not be comparable to
similar measures presented by other companies.

Shareholders and potential investors should not view the adjusted non-IFRS net profit attributable to owners
of the Company on a stand-alone basis or as a substitute for results under the IFRS, or as being comparable
to results reported or forecasted by other companies.

                                                                                            For the year ended December 31,
                                                                                         2020            2019             2018
                                                                                       RMB’000        RMB’000         RMB’000
Profit attributable to owners of the parent....................                         1,172,383         547,190             336,042
Add:
  Share-based compensation expenses ..............................                         51,949            9,496                  –
  Foreign exchange related losses/(gains) .........................                       111,431           (1,579)           (25,530)
  (Gains)/losses on derivative financial instruments
    related to foreign exchange ........................................                 (119,678)           7,364              1,814
Non-IFRS net profit attributable to owners of the
  parent............................................................................    1,216,085         562,471             312,326
Add:
  Realized and unrealized (gains)/losses from equity
    investments.................................................................         (152,056)        (13,338)               886
Non-IFRS adjusted net profit attributable to owners
  of the parent .................................................................       1,064,029         549,133             313,212




                                                                          16
                                                            DEFINITIONS

In this Offering Circular, unless the context otherwise requires, the following expressions shall have the
following meanings.

“A Share(s)”...................................       domestic shares of our Company, with a nominal value of RMB1.00
                                                        each, which are listed for trading on the Shenzhen Stock Exchange
                                                        and traded in Renminbi

“A Share Incentive Scheme” .........                  the share incentive scheme adopted by our Company on August 15,
                                                        2019

“A Share Offering”........................            the initial public offering and listing of A Shares of our Company on
                                                        the Shenzhen Stock Exchange in January 2019

“Articles of Association” or                          the articles of association of our Company, as amended
   “Articles”....................................

“Board” or “Board of Directors”                     the Board of Directors of our Company

“Bondholder” or “Holder” ............               a holder of the Bonds

“Business Day” or “business                          any day (other than a Saturday, Sunday or public holiday) on which
   day” ............................................   banks in Hong Kong are generally open for normal banking business
                                                        to the public

“CAGR” .........................................      compound annual growth rate

“CCASS” ........................................      the Central Clearing and Settlement System established and
                                                        operated by HKSCC

“CCASS Clearing Participant”.....                     a person admitted to participate in CCASS as a direct clearing
                                                        participant or general clearing participant

“CCASS Custodian Participant” ..                      a person admitted to participate in CCASS as a custodian participant

“CCASS Investor Participant” .....                    a person admitted to participate in CCASS as an investor participant
                                                        who may be an individual, joint individuals or a corporation

“CCASS Operational                                     the operational procedures of HKSCC in relation to CCASS,
   Procedures” ................................        containing the practices, procedures and administrative
                                                        requirements relating to the operations and functions of CCASS, as
                                                        from time to time in force

“CCASS Participant” ....................              A CCASS Clearing Participant, a CCASS Custodian Participant or a
                                                        CCASS Investor Participant

“CFIUS” .........................................     Committee on Foreign Investment in the United States

“China” or “PRC” .........................          the People’s Republic of China, excluding, for the purpose of this
                                                        Offering Circular only, Hong Kong, Macau and Taiwan




                                                                     17
“CITIC M&A Fund” .....................              CITIC M&A Fund Management Co., Ltd (
                                                        ), a company established in the PRC on September 4, 2012 with
                                                      limited liability and is wholly-owned by Gold Stone Investment,
                                                      which is in turn wholly-owned by CITIC Securities Company
                                                      Limited, a company listed on the Hong Kong Stock Exchange (stock
                                                      code: 6030)

“Clearing Systems”........................          Euroclear and Clearstream

“Companies Ordinance” ...............               the Companies Ordinance (Chapter 622 of the Laws of Hong Kong),
                                                      as amended, supplemented or otherwise modified from time to time

“Companies (Winding up and                           the Companies (Winding up and Miscellaneous Provisions)
   Miscellaneous Provisions)                          Ordinance (Chapter 32 of the Laws of Hong Kong), as amended,
   Ordinance” .................................      supplemented or otherwise modified from time to time

“Company”, “the Company”, “the                   Pharmaron Beijing Co., Ltd. (            (    )
   Issuer”, or “we”..........................        ), a joint stock limited company incorporated under the laws of
                                                      the PRC, the predecessor of which, Pharmaron Beijing Ltd. (
                                                        (     )                   ) was established under the laws of the
                                                      PRC as an enterprise legal person in July 2004, the A Shares of
                                                      which are listed on the Shenzhen Stock Exchange (stock code:
                                                      300759) and the H Shares of which are listed on the Main Board of
                                                      the Hong Kong Stock Exchange (stock code: 3759) and if the
                                                      context requires, includes its predecessor.

“Company Law” or “PRC                              Company Law of the People’s Republic of China (
   Company Law” ..........................                  ) as amended, supplemented or otherwise modified from time
                                                      to time, which was lately amended on October 26, 2018 to take
                                                      effective on the same date

“CR Medicon” ...............................        Nanjing Ximaidi Medical Technology Co., Ltd. (
                                                                 ) a company incorporated in PRC on January 20, 2017,
                                                      which is held as of 100% by Nanjing Sirui Biotechnology Co., Ltd.
                                                      (                          ), our subsidiary

“CR Medicon Research” ...............               CR Medicon Research, Inc., a company incorporated in the State of
                                                      Delaware on February 11, 2019, which is held as to 100% by
                                                      Nanjing Ximaidi, our subsidiary

“CSRC” ..........................................   the China Securities Regulatory Commission (
                                                           )

“Director(s)” ..................................    director(s) of our Company

“Dr. LOU”......................................     Dr. LOU Boliang (         ), our chairman, chief executive officer
                                                      and executive Director, and a substantial shareholder upon Listing.
                                                      Dr. LOU is a brother of Mr. LOU

“EIT Law” .....................................     Enterprise Income Tax Law of the PRC (
                                                           ), as amended, supplemented or otherwise modified from time
                                                      to time




                                                                   18
“EMA” ...........................................       European Medicines Agency, a European Union body responsible
                                                          for the protection and promotion of human and animal health by
                                                          means of evaluating and monitoring medicines within the European
                                                          Union and the European Economic Area

“EU” ...............................................    European Union

“Exchange Participants” ...............                 a person: (a) who, in accordance with the Hong Kong Listing Rules,
                                                          may trade on or through the Hong Kong Stock Exchange; and (b)
                                                          whose name is entered in a list, register or roll kept by the Hong
                                                          Kong Stock Exchange as a person who may trade on or through the
                                                          Hong Kong Stock Exchange

“FDA” ............................................      the Food and Drug Administration of the United States

“Founders” or “our Founders” .....                    Dr. LOU, Mr. LOU and Ms. ZHENG

“Frost & Sullivan” ........................             Frost & Sullivan (Beijing) Inc., Shanghai Branch Co., an
                                                          independent market research and consulting company

“FVTPL” ........................................        fair value through profit or loss

“GAAP” .........................................        Generally Accepted Accounting Principles

“GFA” ............................................      gross floor area

“Global Offering” ..........................            the Hong Kong Public Offering and the International Offering

“Gold Stone Investment” ..............                  Gold Stone Investment Co., Ltd. (                 ), a company
                                                          established in the PRC on October 11, 2007 with limited liability
                                                          and is wholly-owned by CITIC Securities Company Limited, a
                                                          company listed on the Hong Kong Stock Exchange (stock code:
                                                          6030)

“Group,” “our Group,” “we” or                       our Company and its subsidiaries (or our Company and any one or
   “us” .............................................   more of its subsidiaries, as the context may require)

“H Share(s)” ..................................         overseas-listed foreign shares in the share capital of our Company
                                                          with nominal value of RMB1.00 each, which are to be subscribed for
                                                          and traded in HK dollars and are to be listed on the Hong Kong
                                                          Stock Exchange

“HK$” or “HK dollars” .................               Hong Kong dollars, the lawful currency of Hong Kong

“Hong Kong” or “HK” ..................                the Hong Kong Special Administrative Region of the PRC

“Hong Kong Listing Rules” or                            the Rules Governing the Listing of Securities on The Stock
   “Listing Rules”...........................           Exchange of Hong Kong Limited (as amended from time to time)




                                                                       19
“IFRS” ...........................................   International Financial Reporting Standards, which include
                                                       standards, amendments and interpretations promulgated by the
                                                       International Accounting Standards Board and the International
                                                       Accounting Standards and interpretation issued by the International
                                                       Accounting Standards Committee

“IIT Law” ......................................     the Individual Income Tax Law of the PRC (
                                                                   )

“Legend Capital”...........................          Legend Capital Co., Ltd. (                           ) (formerly
                                                       known as Legend Capital Investment Co., Ltd. (
                                                          )), a company established in the PRC in November 19, 2003 and
                                                       is owned as to 80% by Beijing Juncheng Hezhong Investment
                                                       Management Partnership (Limited Partnership) (
                                                                     (          )) and 20% by Legend Holdings
                                                       Corporation, a company listed on the Hong Kong Stock Exchange
                                                       (stock code: 3396). Legend Capital controls and is deemed to be
                                                       interested in our A Shares held by Tianjin Junlian Wenda Equity
                                                       Investment Partnership (Limited Partnership) (
                                                                   (         )) and Beijing Junlian Maolin Equity
                                                       Investment Partnership (Limited Partnership) (
                                                                   (         ))

“LinkStart” ....................................     Beijing LinkStart Biotechnology Co., Ltd. (
                                                                  ), a company incorporated in PRC on July 19, 2012, one
                                                       of our associates. We own 48% of the equity interests in LinkStart.
                                                       The other shareholders of LinkStart include Liu Yang (22.4%), Qiu
                                                       Shuangjun (1.6%), Beijing Deshu Enterprise Management Center
                                                       (Limited Partnership) (8%), and Yu Yuejiang (20%), each being an
                                                       Independent Third Party

“M&A” ...........................................    merger and acquisition

“Main Board” ................................        the stock market (excluding the option market) operated by the
                                                       Hong Kong Stock Exchange which is independent from and
                                                       operated in parallel with the Growth Enterprise Market of the Hong
                                                       Kong Stock Exchange

“Model Code” ................................        the Model Code for Securities Transactions by Directors of Listed
                                                       Issuers as set out in Appendix 10 to the Listing Rules

“MOF” ...........................................    the Ministry of Finance of the PRC (                         )

“MOFCOM” ..................................          the Ministry of Commerce of the PRC (                            )

“Mr. LOU” .....................................      Lou Xiaoqiang (        ), our chief operating officer, president and
                                                       executive Director, and a substantial shareholder upon Listing. Mr.
                                                       LOU is a brother of Dr. LOU and the spouse of Ms. ZHENG

“Ms. ZHANG” ...............................          Jane Jinfang ZHANG, the spouse of Dr. LOU




                                                                    20
“Ms. ZHENG” ...............................          Zheng Bei (       ), our executive vice president and executive
                                                       Director, and a substantial shareholder upon Listing. Ms. ZHENG is
                                                       the spouse of Mr. LOU

“Nanjing Sirui”..............................        Nanjing Sirui Biotechnology Co., Ltd. (
                                                         ), a company incorporated in PRC on February 7, 2018 and is held
                                                       as to 55.56% by our Company

“NDRC” .........................................     the National Development and Reform Commission of the PRC (
                                                                                         )

“NEEQ” .........................................     National Equities Exchange and Quotations (
                                                           )

“NMPA” .........................................     National Medical Product Administration (                        )
                                                       (formerly known as China Food and Drug Administration)

“NPC” ............................................   the National People’s Congress of the PRC (
                                                                  )

“NYSE” ..........................................    New York Stock Exchange

“OECD” .........................................     Organization for Economic Co-operation and Development, an
                                                       intergovernmental economic organization founded to stimulate
                                                       economic progress and world trade

“PBOC”..........................................     the central bank of the People’s Republic of China (            )

“Pharmaron ABS” .........................            Pharmaron ABS, Inc., formerly known as Xceleron Inc., a company
                                                       incorporated in the U.S. on October 31, 2001, which is held as to
                                                       100% by Pharmaron HK International, our wholly-owned subsidiary

“Pharmaron Biologics HK” ..........                  Pharmaron Biologics (Hong Kong) Limited, a company
                                                       incorporated in Hong Kong on June 11, 2018, which is held as to
                                                       100% by Pharmaron HK International, our wholly-owned subsidiary

“Pharmaron CPC” ........................             Pharmaron CPC, Inc., formerly known as SNBL Clinical
                                                       Pharmacology Center, Inc., a company incorporated in the U.S. on
                                                       October 7, 2004, which is held as to 80% by Pharmaron HK
                                                       International, our wholly-owned subsidiary, and 20% by Shin
                                                       Nippon Biomedical Laboratories, Ltd.

“Pharmaron CRI” .........................            Pharmaron CRI (Ningbo) Co., Ltd. (                     (    )
                                                              ), a company incorporated in the PRC on August 18, 2016,
                                                       which is held as to 100% by Pharmaron Ningbo, our wholly-owned
                                                       subsidiary

“Pharmaron HK International” ...                     Pharmaron (Hong Kong) International Limited, a company
                                                       incorporated in Hong Kong on December 31, 2015, our wholly-
                                                       owned subsidiary




                                                                    21
“Pharmaron HK Investment” .......             Pharmaron (Hong Kong) Investments Limited, a company
                                                incorporated in Hong Kong on February 11, 2016, which is held as
                                                to 100% by Pharmaron HK International, our wholly-owned
                                                subsidiary

“Pharmaron, Inc.” .........................   Pharmaron, Inc., a company incorporated in the U.S. on December
                                                22, 2006, which is held as to 100% by Pharmaron US, Inc., our
                                                wholly-owned subsidiary

“Pharmaron Ningbo” ....................       Pharmaron Ningbo Co., Ltd. (        (    )                 ), a
                                                company incorporated in the PRC on January 9, 2015, our wholly-
                                                owned subsidiary

“Pharmaron Ningbo Biologics” ....             Pharmaron (Ningbo) Biologics Co., Ltd. (     (     )
                                                        ), a company incorporated in PRC on August 31, 2018,
                                                which is held as to 100% by Pharmaron Biologics HK, our
                                                wholly-owned subsidiary

“Pharmaron Shanghai” .................        Pharmaron Shanghai Co., Ltd. (      (   )                ),
                                                a company incorporated in the PRC on February 11, 2018, our
                                                wholly-owned subsidiary

“Pharmaron Shaoxing” .................        Pharmaron Shaoxing Co., Ltd. (          (    )             ), a
                                                company incorporated in the PRC on January 3, 2017, our wholly-
                                                owned subsidiary

“Pharmaron Tianjin” ....................      Pharmaron (Tianjin) Process Development and Manufacturing Co.,
                                                Ltd.    (        (    )                     ),  a    company
                                                incorporated in the PRC on July 16, 2008, our wholly-owned
                                                subsidiary

“Pharmaron TSP” .........................     Pharmaron (Beijing) TSP Services Co., Ltd. (      (   )
                                                           ), a company incorporated in the PRC on January 11,
                                                2006, our wholly-owned subsidiary

“Pharmaron UK”...........................     Pharmaron UK Limited, formerly known as Quotient Bioresearch
                                                Group Limited, a company incorporated in the U.K. on October 30,
                                                2013, which is held as to 100% by Pharmaron HK International, our
                                                wholly-owned subsidiary

“Pharmaron UK Bioresearch” ......             Quotient Bioresearch (Rushden) Limited, a company incorporated in
                                                the U.K. on August 7, 2000, which is held as to 100% by Pharmaron
                                                UK

“Pharmaron UK                                  Quotient Bioresearch (Radiochemicals) Limited, a company
   Radiochemicals”.........................    incorporated in the U.K. on April 9, 2009, which is held as to 100%
                                                by Pharmaron UK

“Pharmaron US, Inc.” ...................      Pharmaron US, Inc., a company incorporated in the U.S. on
                                                August 1, 2015 and our wholly-owned subsidiary




                                                             22
“Pharmaron Xi’an” .......................            Pharmaron Xi’an Co., Ltd. (       (   )                ), a
                                                        company incorporated in the PRC on May 11, 2010, our wholly-
                                                        owned subsidiary

“PRC GAAP”.................................           Chinese Accounting Standards

“R&D”............................................     research and development

“Regulation S” ...............................        Regulation S under the U.S. Securities Act

“Restricted A Shares” ...................             the restricted A Shares granted by our Company under the A Share
                                                        Incentive Scheme

“RMB” or “Renminbi” ..................              Renminbi, the lawful currency of the PRC

“SAFE” ..........................................     the State Administration of Foreign Exchange of the PRC (
                                                                    )

“SAT” .............................................   the State Administration of Taxation of the PRC (
                                                          )

“Securities Law”............................          the Securities Law of the PRC (                           ), as
                                                        amended, supplemented or otherwise modified from time to time

“SFC” .............................................   the Securities and Futures Commission of Hong Kong

“SFO”.............................................    the Securities and Futures Ordinance (Chapter 571 of the Laws of
                                                        Hong Kong), as amended, supplemented or otherwise modified from
                                                        time to time

“Share(s)”.......................................     ordinary shares in the capital of our Company with a nominal value
                                                        of RMB1.00 each, comprising A Shares and H Shares

“Shareholder(s)” ............................         holder(s) of the Share(s)

“Shenzhen Stock Exchange” .........                   Shenzhen Stock Exchange (                    )

“Shenzhen Stock Exchange                               the Rules Governing the Listing of Stocks on the Shenzhen Stock
   Listing Rules” ............................         Exchange (                             ) as amended from time to
                                                        time

“SOP”.............................................    standard operating procedure

“sq.m.” ...........................................   square meter

“State Council” ..............................        the State Council of the PRC (                       )

“Supervisor(s)” ..............................        member(s) of our Supervisory Committee

“U.K.” ............................................   United Kingdom




                                                                       23
“U.S.” or “United States” ..............    the United States of America, its territories, its possessions and all
                                                areas subject to its jurisdiction

“U.S. Securities Act” .....................   the United States Securities Act of 1933, as amended, and the rules
                                                and regulations promulgated thereunder

“US$”, “USD” or “U.S. dollars”....        United States dollars, the lawful currency of the United States


In this Offering Circular, the terms “associate,” “subsidiaries” and “substantial shareholder” shall have
the meanings given to such terms in the Hong Kong Listing Rules, unless the context otherwise requires.

Certain amounts and percentage figures included in this Offering Circular have been subject to rounding.
Accordingly, figures shown as totals in certain tables may not be an arithmetic aggregation of the figures
preceding them. Any discrepancies in any table or chart between the total shown and the sum of the amounts
listed are due to rounding.

For ease of reference, the names of the PRC established companies or entities, laws or regulations have
been included in this Offering Circular in both the Chinese and English languages; in the event of any
inconsistency, the Chinese versions shall prevail.




                                                             24
                                         GLOSSARY OF TECHNICAL TERMS

“ 14C” ..............................................   Carbon-14 (14C), or radiocarbon, a radioactive isotope of carbon
                                                          with an atomic nucleus containing 6 protons and 8 neutrons

“ 3H”................................................   tritium or Hydrogen-3, a radioactive isotope of hydrogen, whose
                                                          nucleus contains one proton and two neutrons

“Ci” ..............................................     microCuries, radioactivity unit

“AAALAC” ....................................           AAALAC International, a private nonprofit organization that
                                                          promotes the humane treatment of animals in science through
                                                          voluntary accreditation and assessment programs

“absorption” ..................................         within the context of drug metabolism, the process by which drug
                                                          compounds and other molecules move across cells and tissues such
                                                          as the gastrointestinal tract into the circulatory system

“ADC” ............................................      antibody-drug conjugates, a class of biopharmaceutical drugs
                                                          designed as a targeted therapy

“ADME”.........................................         absorption, distribution, metabolism and excretion, the analysis of
                                                          the body’s processes of altering, utilizing and eliminating ingested
                                                          and administered drugs and xenobiotics, either in an in vitro or in
                                                          vivo setting

“AME” ...........................................       clinical absorption, metabolism and excretion, the complete drug
                                                          disposition process

“AMS”............................................       accelerator mass spectrometry, a form of mass spectrometry that
                                                          accelerates ions to extraordinarily high kinetic energies before mass
                                                          analysis

“antibody” or “Ab”........................            also known as an immunoglobulin, a large, Y-shaped protein
                                                          produced mainly by plasma cells that is used by the immune system
                                                          to identify and neutralize pathogens such as bacteria and viruses

“API”..............................................     active pharmaceutical ingredient, the component of a drug product
                                                          that is intended to furnish pharmacological activity or other direct
                                                          effect in the diagnosis, cure, mitigation, treatment, or prevention of
                                                          disease, or to affect the structure or any function of the body

“Assay”...........................................      an investigative analytical process in medicine, pharmacology or
                                                          biology that aims to identify either the qualitative or quantitative
                                                          presence or function of the analytical target, which can be a drug or
                                                          biochemical substance or a cell in an organism or organic sample

“bioanalysis” ..................................        a sub-discipline of analytical science covering the quantitative
                                                          measurement of xenobiotics (drugs, their metabolites, and
                                                          biological molecules in unnatural locations or concentrations) and
                                                          biotics (macromolecules, proteins, DNA, biologics, metabolites) in
                                                          biological systems




                                                                       25
“biohazardous” ..............................       of or relating to the health risk posed by the possible release of a
                                                      pathogen into the environment

“biologics”......................................   a subset of pharmaceuticals that include antibodies, proteins, nucleic
                                                      acids and ADCs

“CADD” .........................................    computer-aided drug design, the use of computers (or workstations)
                                                      to aid in the creation, modification, analysis, or optimization of
                                                      novel compounds or biologics

“candidate selection” .....................         a stage in early drug discovery where a compound that indicates
                                                      highest potential for desirable effects is selected for further
                                                      intensive study and analysis

“CDISC” ........................................    the Clinical Data Interchange Standards Consortium, a standards
                                                      developing organization dealing with medical research data to
                                                      develop and advance data standards to transform incompatible
                                                      formats, inconsistent methodologies, and diverse perspectives into a
                                                      framework for generating high quality clinical research data

“CDMO” ........................................     contract development and manufacturing organization, a CMO that,
                                                      in addition to comprehensive drug manufacturing services, also
                                                      provide process development and other drug development services
                                                      in connection with its manufacturing services

“cGMP” or “GMP” ........................          current Good Manufacturing Practice, regulations enforced by the
                                                      FDA or other regulatory authorities on pharmaceutical and
                                                      biotechnology firms to ensure that the products produced meet
                                                      specific requirements for identity, strength, quality and purity

“chemoproteomics”........................           chemoproteomics is an approach to discovering mechanisms for
                                                      regulating biological pathways for the purpose of identifying novel
                                                      biological targets and discovering new pharmaceutical therapies. It
                                                      is a chemical proteomic method for pharmacological discovery
                                                      research

“clinical pathology” .......................        the branch of pathology dealing with the study of disease and
                                                      disease processes by means of chemical, microscopic, and serologic
                                                      examinations

“clinical trial” ................................   an experiment done in clinical research

“CMC” or “chemistry,                               an important and detailed section in a dossier to support clinical
   manufacturing and controls” ....                  studies and marketing applications

“CMO” ...........................................   contract manufacturing organization, a company that serves other
                                                      companies in the pharmaceutical industry on a contract basis to
                                                      provide comprehensive drug manufacturing services

“commercialization” ......................          the stage in drug development when a new drug is approved and
                                                      publicly marketed




                                                                   26
“CRO”............................................     contract research organization, a company focused on providing
                                                        pharmaceutical    research    and   development   services  to
                                                        pharmaceutical companies

“DART”..........................................      developmental and reproductive toxicology, the study of fertility,
                                                        development toxicity and pre/postnatal development and other
                                                        specialized functional evaluations in connection with the toxicology
                                                        evaluation for pharmaceuticals

“distribution”.................................       in the context of DMPK, the process by which molecules are
                                                        transported throughout the body

“DMPK”.........................................       drug metabolism and pharmacokinetics, the studies designed to
                                                        determine the absorption, metabolism, excretion and the kinetic
                                                        study of a drug or potential drug either in an in vitro or in vivo
                                                        setting

“DNA” ............................................    a molecule that carries most of the genetic instructions used in the
                                                        development, functioning and reproduction of all known living
                                                        organisms and many viruses

“drug discovery” ...........................          the process through which potential new medicines are identified
                                                        and may involve a wide range of scientific disciplines, including
                                                        biology, chemistry and pharmacology

“ex vivo”.........................................    Latin for “out of the living”; refers to experimentation or
                                                        measurements done in or on tissue from an organism in an external
                                                        environment with minimal alteration of natural conditions

“FFS” .............................................   fee-for-service, a payment model where services are unbundled and
                                                        paid for separately

“first-in-human (FIH) studies” .....                  phase I clinical studies which include evaluation of
                                                        pharmacokinetics, safety and tolerability of an investigational drug
                                                        in human

“formulation development”...........                  a stage of analyzing and refining the physio-chemical structure of a
                                                        product to stabilize or enhance its suitability for use in in vivo
                                                        testing. Formulation development may also include assessing
                                                        delivery options and delivery device compatibility

“FTE”.............................................    full-time-equivalent, a payment model based on the number of
                                                        researchers allocated to, and the duration of, a given project

“fusion protein” .............................        proteins created through the joining of two or more genes that
                                                        originally coded for separate proteins

“GCP” ............................................    Good Clinical Practice, an international ethical and scientific quality
                                                        standard for the performance of a clinical trial on medicinal
                                                        products involving humans




                                                                     27
“GLP” ............................................    Good Laboratory Practice, a quality system of management controls
                                                        for research laboratories and organizations to try to ensure the
                                                        uniformity, consistency, reliability, reproducibility, quality and
                                                        integrity of chemical and pharmaceuticals non- clinical safety tests

“GPCRs” ........................................      G-protein-coupled receptors, the largest and most diverse group of
                                                        membrane receptors in eukaryotes. These cell surface receptors act
                                                        like an inbox for messages in the form of light energy, peptides,
                                                        lipids, sugars, and proteins

“hit identification” or “HI” ...........            the first committed step for a successful drug discovery project. In
                                                        this process, the right small molecules, also called hits, binding to
                                                        the target and modifying its function are identified

“hit-to-lead” ...................................     a stage in early drug discovery where small molecule hits from a
                                                        high throughput screen are evaluated and undergo limited
                                                        optimization to identify promising lead compounds

“HPLC”..........................................      high-performance liquid chromatography, a technique in analytical
                                                        chemistry used to separate, identify, and quantify each component in
                                                        a mixture

“HTS”.............................................    high-throughput screening, a method for scientific experimentation
                                                        especially used in drug discovery and relevant to the fields of
                                                        biology and chemistry

“ICH” .............................................   International Conference on Harmonization of Technical
                                                        Requirements for Registration of Pharmaceuticals for Human Use, a
                                                        project that brings together the regulatory authorities of Europe,
                                                        Japan, China, the U.S. and other countries and experts from the
                                                        pharmaceutical industry in these regions for the purpose of reducing
                                                        or eliminating the need to duplicate the testing carried out during the
                                                        research and development of new medicines by recommending ways
                                                        to achieve greater harmonization in the interpretation and
                                                        application of technical guidelines and requirements for product
                                                        registration

“ICP-MS”.......................................       inductively coupled plasma mass spectrometry, a type of mass
                                                        spectrometry which is capable of detecting metals and several
                                                        non-metals at low concentrations on non-interfered low-background
                                                        isotopes

“ICP-OES” .....................................       inductively coupled plasma optical emission spectrometry, an
                                                        analytical technique used for the detection of chemical elements

“investigational new drug” or                         an experimental drug for which a pharmaceutical company obtains
   “IND applications”.....................            permission to conduct clinical trials before a marketing application
                                                        for the drug has been approved

“in vitro” ........................................   Latin for “in glass”; studies in vitro are conducted using components
                                                        of an organism that have been isolated from their usual biological
                                                        surroundings, such as microorganisms, cells or biological molecules




                                                                     28
“in vivo” .........................................   Latin for “within the living”; studies in vivo are those in which the
                                                        effects of various biological entities are tested on whole, living
                                                        organisms as opposed to a partial or dead organism, or those done in
                                                        vitro

“LCMS” .........................................      liquid chromatography-mass spectrometry, an analytical chemistry
                                                        technique that combines the physical separation capabilities of
                                                        liquid chromatography with the mass analysis capabilities of mass
                                                        spectrometry

“lead generation” or “LG” ............              lead generation is a stage in early drug discovery where small
                                                        molecule hits from a high throughput screen (hits) are evaluated and
                                                        undergo limited optimization to identify promising lead compounds

“lead optimization” .......................           the stage of early drug discovery where promising lead compounds
                                                        are further optimized in preparation for toxicity assessment prior to
                                                        human clinical trials

“MAH” ...........................................     Market Authorized Holder, a certification granted by the NMPA,
                                                        which allows certain license holders to use a qualified CMO to
                                                        manufacture pharmaceutical products

“metabolism” .................................        the chemical processes that occur within a living organism in order
                                                        to maintain life, comprising catabolism (breakdown of larger
                                                        molecules into components) and anabolism (the synthesis of smaller
                                                        molecules into larger ones with specific structures, characteristics
                                                        and purposes)

“metabolites” .................................       a metabolite of a drug is a compound formed from the drug’s
                                                        original components through metabolism

“method validation” ......................            an assessment of a procedure to ensure it meets its own analytical
                                                        objectives and produces results with sufficient accuracy, precision
                                                        and productibility

“molecule”......................................      a group of two or more atoms held together by chemical bonds

“NDA” ............................................    new drug application, the formal application to competent
                                                        authorities such as the FDA or the NMPA proposing approval of a
                                                        new pharmaceutical product for sale and marketing

“oncology”......................................      the study and treatment of tumors

“peptide” ........................................    small fragments of proteins, composed of amino acids

“pharmacodynamics” or “PD” ......                   the study of the biochemical and physiologic effects of drugs
                                                        (especially pharmaceutical drugs)

“pharmacokinetics” or “PK” .........                the branch of DMPK concerned with the kinetic study of absorption,
                                                        distribution and excretion of drugs or potential drugs either in an in
                                                        vitro or in vivo setting




                                                                     29
“pharmacology” .............................         the branch of medicine concerned with the uses, effects, and modes
                                                       of action of drugs

“POC” ............................................   proof of concept, a realization of a certain method or idea in order
                                                       to demonstrate its feasibility, or a demonstration in principle with
                                                       the aim of verifying that some concept or theory has practical
                                                       potential. In a medical setting, POC means a realization of adequate
                                                       medical efficacy and safety have been demonstrated in patients by
                                                       interfering with intended biological targets with medicines

“preclinical” ...................................    of or relating to a stage preceding a clinical stage

“radioisotope based compound                          a platform that combines the synthesis of a radioactive compound,
   synthesis-clinical-analysis                         its test in human and analysis of the parent drug/metabolites in
   techniques” .................................      human fluids and excretes

“recombinant” ...............................        of or relating to the combination of genetic materials from more than
                                                       one origin

“release testing”.............................       an assessment of the measure of release of the active pharmaceutical
                                                       ingredient (API) from the drug product matrix in controlled
                                                       conditions

“siRNA” .........................................    small interfering RNA (siRNA), sometimes known as short
                                                       interfering RNA or silencing RNA, which is a class of
                                                       double-stranded RNA molecules, 20-25 base pairs in length, and
                                                       operating within the RNA interference (RNAi) pathway

“small molecule”............................         within the fields of molecular biology and pharmacology, a low
                                                       molecular weight organic compound that may regulate a biological
                                                       process, with a size in the order of 1 nanometer

“SMO”............................................    site management organization, an organization that provides clinical
                                                       trial related services to a CRO, a pharmaceutical company, a biotech
                                                       company, a medical device company or a clinical site

“synthesis” .....................................    the production of chemical compounds by reaction from simpler
                                                       materials

“validation”....................................     a process that involves performing laboratory tests to verify that a
                                                       particular instrument program, or measurement technique is
                                                       working properly and is capable of being relied upon




                                                                    30
                                           RISK FACTORS

Prospective investors of the Bonds should carefully consider the risk factors set forth below, as well as the
other information contained elsewhere in this Offering Circular. The risks described below are not the only
ones that may affect the Issuer, the Group or the Bonds. Additional risks and uncertainties which the Issuer
is not aware of or that the Issuer currently believes are immaterial may also adversely affect the Group’s
financial condition or results of operations. If any of the possible events described below occur, the Group’s
financial condition or results of operations could be materially and adversely affected. In such case, the
Issuer may not be able to satisfy their respective obligations under the Bonds, and investors could lose all
or part of their investment. This Offering Circular also contains forward-looking statements that involve
risks and uncertainties. The Group’s actual results could differ materially from those anticipated in these
forward-looking statements as a result of certain factors.

RISKS RELATING TO OUR BUSINESS AND INDUSTRY

Our business largely depends on our customers’ demand for pharmaceutical R&D services and their
budget for R&D expenditure. Any reduction in demand from our customers could have a material adverse
effect on our business, financial condition, results of operations and prospects.

We are a leading fully-integrated pharmaceutical R&D service platform with global operations to accelerate
drug innovation for our customers. The success of our business largely depends on the number and size of
service agreements that we obtain from our customers, including pharmaceutical and biotechnology
companies, pursuant to which these customers outsource their R&D projects to us. Over the past several
years, we have benefitted from an increased demand for our services primarily as a result of the continued
growth of the pharmaceutical and biotechnology industry and increasing R&D expenditures of our
customers.

Although the global pharmaceutical and biotechnology industries are expected to continue to grow driven
by such factors as an aging population, higher disposable income and increased spending on healthcare,
there can be no assurance that these industries will continue to grow at rates we expect or at all. Any slowing
or reversal of such trends may cause our customers to suspend their pharmaceutical R&D projects or to
reduce their R&D budget, thereby diminishing the growth in our business and materially and adversely
affect our business, financial condition, results of operations and prospects.

With the growth in the global pharmaceutical and biotechnology industries, there has been a corresponding
increase in the demand for expertise in the drug discovery, development and manufacturing process in
recent years. At present, pharmaceutical and biotechnology companies seek to collaborate with CROs and
CMOs with scientific expertise and favorable pricing terms, making CROs and CMOs valuable partners for
them. However, we cannot assure you that such trend to pursue external R&D support will continue in the
future. Our customers’ demand for pharmaceutical R&D services is subject to a variety of factors, including
their decisions to acquire or develop in-house research, development and manufacturing capacity, their new
product development plans, the availability of internal and external funding, spending priorities and internal
budgetary policies, negative trend in general economic condition or global pharmaceutical and
biotechnology market as well as their perception of future market trends. If our customers reduce their
spending on our services as a result of any of the above or other factors, we may not be able to locate
sufficient number of customers for the continuous growth of our business, and our business, financial
condition, results of operations and prospects may be materially and adversely affected.

Our success depends on our ability to attract, train, retain and motivate highly skilled scientists and other
technical personnel.

Along with our continued expansion, we have established a highly experienced talent pool with strong
execution capabilities. Highly skilled and talented scientists help us keep pace with the latest developments
in research, development and manufacturing technologies and methodologies in the pharmaceutical and
biotechnology industries, and are therefore critical to our success. Our business operations also rely on


                                                      31
personnel possessing highly technical skills for our quality control, compliance, environmental protection,
safety and health, information technology and marketing. In order to develop and retain our talents, we
provide continuous training programs to our employees through “Pharmaron College”, offer visiting scholar
programs at renowned laboratories and institutions, and hold various symposiums, forums and lectureship.
We also offer employee share incentive programs to our key employees and thus provide them with an
opportunity to share the growth of our business.

We intend to continue to attract and retain highly skilled scientists and other technical personnel. However,
as there is a limited supply of qualified scientists and R&D personnel with requisite experience and
expertise, and such qualified personnel are also highly-sought after by pharmaceutical companies, biotech
start-ups and scientific research institutes, we have to provide competitive compensation and benefits
packages to attract and retain talents. We cannot assure you that we will always be able to hire and retain
the requisite number of qualified personnel to keep pace with our anticipated growth while maintaining
consistent quality of our services. In addition, we may not always be successful in training our professionals
to quickly adapt to technological advances, evolving standards and changing customer needs, and the
quality of our services may therefore be severely affected. Any failure to attract, train or retain highly
excellent scientific and technological personnel may materially and adversely affect our reputation,
business, financial condition, results of operations and prospects.

The continuing and collaborative efforts of our senior management and key scientific personnel are
crucial to our success, and our business could be severely disrupted if we lose their services.

The continued service of our senior management and key scientific personnel is critical to the success of
our business. In particular, we are dependent on our senior management team led by Dr. LOU, our chairman
and chief executive officer, for their management, supervision and planning of our business. Our senior
management team has been with us for more than 10 years and their technical and industry expertise have
significantly contributed to the growth of our institutional knowledge base. The loss of service with respect
to any of our senior management or key scientific personnel may have a material adverse effect on our
business and operations. If we lose the services of any senior management member or key scientific
personnel, we may be unable to identify and retain a suitable qualified replacement and may incur
additional expenses and time to recruit and train new personnel, which could severely disrupt our business
operations. Although each of our senior management member and key scientific personnel has signed a
non-compete agreement with us, we may not be able to enforce these provisions should any of them leaves
us to join a competitor or to start his/her own business which competes with us, and our business operations
and prospects could be materially and adversely affected.

If we fail to protect the intellectual property rights or confidential information of our customers, we will
be subject to legal liabilities and our reputation may be damaged.

Protection of intellectual property rights and confidential information associated with pharmaceutical and
biotechnology pharmaceutical R&D services is critical to all of our customers. Our customers generally
retain ownership of the intellectual property rights that they provide to us and those arising from the
services we provide. The service agreements and confidentiality agreements signed between us and our
customers typically require us to exercise all reasonable precautions to protect the integrity and
confidentiality of our customers’ information. Our success therefore depends in substantial part on our
ability to protect the intellectual property rights and confidential information of our customers.
Notwithstanding our efforts to protect our customers’ intellectual property rights and confidential
information, unauthorized parties may still attempt to obtain and use such information that we regard as
confidential. Any unauthorized disclosure of our customers’ proprietary rights or confidential information
could subject us to liability for breach of contract and result in significant damage to our reputation, which
could materially harm our business, financial condition, results of operations and prospects, and any
remediation efforts may significantly divert our management’s attention and resources from other activities.



                                                     32
Any failure to comply with existing laws, regulations and industry standards or any adverse actions by
the competent authorities against us could adversely affect our reputation and our business, financial
condition, results of operations and prospects.

There are strict laws, regulations and industry standards in many countries or regions to which drugs are
intended to be ultimately sold (such as China, the U.S., the U.K. and several EU countries) to regulate drug
development and manufacturing. The pharmaceutical regulatory authorities of these countries (e.g., the
FDA or the NMPA) also conduct planned or unplanned facility inspections over drug development and
manufacturing agencies (e.g., our customers and us) to ensure that relevant facilities meet regulatory
requirements. For example, we may need to obtain clearance from the FDA or the NMPA or other regulatory
authorities in the event that our customers’ preclinical trials are filed as part of an IND filing to seek
authorization to begin clinical trials, or their clinical trials are filed as part of a NDA or other filings to seek
marketing approval. Although we have passed the inspections in relation to drug discovery, development
and manufacturing conducted by the relevant regulatory authorities in all material respects during the three
years ended December 31, 2020, we cannot assure you that we will be able to pass all such inspections in
the future. Any failure to comply with existing regulations and industry standards could result in fines,
revocation of accreditation or other punitive actions against us or our customers, the termination of ongoing
projects by our customers and the disqualification of data for submission to regulatory authorities, each of
which could have a material adverse impact on our reputation, business, financial condition, results of
operations and prospects. For example, if we fail to treat research animals in accordance with international
standards set out by the Association for Assessment and Accreditation of Laboratory Animal Care, that
organization could revoke accreditation and the accuracy of our animal research data could be questioned.
In addition, even if we are able to successfully defend against any action for violation of the relevant
regulations or industry standards, such actions could result in diversion of our management’s attention from
the operation of our business, significant legal expenses and adversely affect our reputation and financial
results.

Our failure to obtain or renew certain approvals, licenses, permits or certificates required for our
business may materially and adversely affect our business.

We are subject to certain laws and regulations that require us to obtain and maintain various approvals,
licenses, permits and certificates from different authorities to operate our business. We will face sanctions
or other enforcement actions if we fail to obtain approvals, licenses, permits or certificates as might be
necessary for our operations. We could be ordered by the relevant regulatory authorities to cease operation,
or may be required to undertake corrective measures requiring capital expenditure or other remedial actions,
which could materially and adversely affect our business, financial condition and results of operations.

In addition, some of these approvals, permits, licenses and certificates are subject to periodic renewal and/or
reassessment by the relevant authorities, and the standards of such renewal and/or reassessment may change
from time to time. Although we are committed to applying for the renewal and/or reassessment of these
approvals, permits, licenses and certificates when required by applicable laws and regulations, we cannot
assure you that we can successfully obtain such renewals and/or reassessment. Any failure by us to obtain
the necessary renewals and/or reassessment and otherwise maintain all approvals, licenses, permits and
certificates necessary to carry out our business at any time could cause severe disruption to our business
and prevent us from continuing to carry out our business, which could have a material adverse effect on our
business, financial condition and results of operations.

We may also be required to obtain additional approvals, permits, licenses or certificates that were
previously not required to operate our existing businesses as a result of new regulations coming into effect,
change to interpretation or implementation of existing laws and regulations. We cannot assure you that we
will successfully obtain such approvals, permits, licenses or certificates. Our failure to obtain the additional
approvals, permits, licenses or certificates may restrict the conduct of our business, decrease our revenues
and/or increase our costs, which could materially reduce our profitability and prospects.


                                                        33
We are subject to environmental protection and health and safety laws and regulations, and may be
exposed to potential costs for compliance and liabilities, including consequences of accidental
contamination, biological or chemical hazards, or personal injury.

Our operations are subject to national and local laws with respect to environmental protection, health and
safety, including but not limited to the treatment and discharge of pollutants into the environment and the
use of toxic and hazardous chemicals in the process of our business operations. In addition, our construction
projects can only be put into operation after the relevant administrative authorities in charge of
environmental protection and health and safety have examined and approved the relevant facilities in
certain jurisdictions. For the years ended December 31, 2018, 2019 and 2020, our total cost of compliance
with environmental protection and health and safety laws and regulations was RMB26.9 million, RMB57.3
million and RMB115.3 million, respectively. As requirements imposed by such laws and regulations may
change and more stringent laws or regulations may be adopted, we may not be able to comply with, or
accurately predict any potential substantial cost of complying with, these laws and regulations. If we fail
to comply with environmental protection and health and safety laws and regulations, we may be subject to
rectification orders, substantial fines, potentially significant monetary damages, or production suspensions
in our business operations. As a result, any failure by us to control the use or discharge of hazardous
substances could have a material and adverse impact on our business, financial condition, results of
operations and prospects.

In addition, we cannot fully eliminate the risk of accidental contamination, biological or chemical hazards
or personal injury at our facilities during the process of discovery, testing, development and manufacturing
of pharmaceuticals. In the event of such accident, we could be held liable for damages and clean-up costs
which, to the extent not covered by existing insurance or indemnification, could harm our business. Other
adverse effects could result from such liability, including reputational damage resulting in the loss of
business from customers. We may also be forced to close or suspend operations at certain of our affected
facilities temporarily, or permanently. As a result, any accidental contamination, biological or chemical
hazards or personal injury could have a material and adverse impact on our business, financial condition,
results of operations and prospects.

We face foreign exchange risk, and fluctuations in exchange rates could have a material adverse effect
on our financial condition and results of operations.

Our foreign currency exposure is mainly respect to U.S. dollars, pound sterlings and the euro. During the
three years ended December 31, 2020, a substantial portion of our revenue was generated from sales
denominated in U.S. dollars. However, a significant portion of cost of services and operating costs and
expenses are denominated in Renminbi. As a result, our margins will be under pressure when the Renminbi
appreciates against the U.S. dollar, and we may not be able to price our service contracts, in particular those
with our U.S. customers, in currencies other than the U.S. dollars. In addition, fluctuations in exchange rates
have in the past affected, and could in the future continue to, materially and adversely affect our financial
condition and results of operations as we hold certain assets denominated in foreign currencies. For
example, we recorded net foreign exchange gains of RMB30.1 million and RMB1.9 million for the years
ended December 31, 2018 and 2019, respectively, and a net foreign exchange loss of RMB131.2 million in
2020.

Fluctuations in exchange rates between the Renminbi and the U.S. dollar and other currencies may be
affected by, among other things, changes in China’s political and economic conditions, trade tensions
between the U.S. and China, as well as international economic and political developments. Due to
international pressures on the PRC to allow more flexible exchange rates for the Renminbi and the
economic situation and financial market developments in the PRC and abroad, the PRC government has
decided to proceed further with reform of the Renminbi exchange rate regime and to enhance the Renminbi
exchange rate flexibility. We have used, and may continue to use derivative contracts or hedge against our
exposure to currency risks from time to time. However, the availability and effectiveness of such hedges
may be limited, and we may not be able to successfully hedge our exposure to currency risks.


                                                      34
We face increasing competition and may not be able to compete effectively, which may result in
downward pricing pressure or reduced demand for our services.

The global pharmaceutical R&D service market for pharmaceutical products is highly competitive, and we
expect the level of competition will continue to increase. We face competition in several different areas,
including quality of services, breadth of our integrated services, our capacity and ability to deliver in a
timely manner, our ability to protect intellectual property or other confidential information of our
customers, maintenance of our qualifications and accreditations, depth of customer relationships and prices.

We expect continuous competition from both domestic and international competitors as we continue to
invest in more sophisticated capabilities and capacity in laboratory, clinical development and CMC (small
molecule CDMO) services. We also expect increasing competition as additional competitors enter our
market and as more advanced technologies become available. We compete with other pharmaceutical R&D
service providers typically in specific service areas. We also compete with the in-house discovery, testing,
development and commercial manufacturing functions of pharmaceutical and biotechnology companies.
Some of our competitors may have more financial resources, better research and technical capabilities,
greater pricing flexibility, stronger sales and marketing efforts, longer track record and better brand
recognition. In addition, our competitors may improve the performance of their services, introduce new
services with lower prices and improved performance, or adapt more quickly to new technologies and
changes in customer demand and requirements. Furthermore, increased competition could create additional
pricing pressure on our services, which could reduce our revenue and profitability. There is no assurance
that we will be able to compete effectively with existing competitors or new competitors or that increased
level of competition will not adversely affect our business, results of operations, financial condition and
prospects.

We may not be able to execute our growth strategies or manage our growth effectively.

We plan to maintain our leading position in pharmaceutical R&D services and further expand our
development service offerings, continue to develop and acquire innovative pharmaceutical R&D service
technologies, further capitalize the evolving and fast-growing Chinese market, deepen collaborations with
existing customers and broaden customer base, build capabilities for biologics, and continue to attract, train
and retain talents to support our long-term and sustainable growth. Pursuing our growth strategies has
resulted in, and will continue to result in, substantial demands on capital and other resources. In addition,
managing our growth and executing our growth strategies will require, among other things, our ability to
continue to innovate and develop advanced technology in the highly competitive global pharmaceutical
R&D service market, effectively coordinate and integrate our facilities and teams across different sites, hire,
train and retain qualified personnel, implement effective cost control and quality control, maintain
sufficient liquidity, and effective and efficient financial and management control, carry out increased
marketing and customer support activities, and manage our suppliers to leverage our purchasing power. If
we fail to successfully execute our growth strategies, we may not be able to maintain our growth rate and,
as a result, our business, financial condition, results of operations and prospects may be materially and
adversely affected.

The success of our business expansion also depends on our customers’ success in advancing drug candidates
through development, regulatory approval and commercial manufacturing. Any delay in regulatory
approvals, lower than anticipated treatment effectiveness, unexpected side effect, low success rate or lack
of patient demand may have a material impact on our business. If our growth strategy or business expansion
is not successful or sufficient or does not earn a satisfactory return on investment, our business, financial
condition, results of operations and prospects could be materially and adversely affected.




                                                      35
Our business may be materially and adversely affected by the increasing trade tensions between the U.S.
and China.

As trade tensions increase between the U.S. and China in recent years, concerns exist among PRC
enterprises transacting with U.S. companies that a possible trade war between the two countries could leave
them caught in the crossfire. A breakdown in trade relations between the U.S. and China could also delay
the global economic recovery in recent years, threatening the ongoing economic expansion and the
increasing cross-border transactions trend. Furthermore, concerns arise in the U.S. that certain Chinese
companies may, by leveraging their business relationship with U.S. companies, acquire technologies and
data that enhance such Chinese companies’ capabilities through a variety of channels. As a result, we cannot
assure you that U.S. government will not adopt relevant policies or practices to mitigate against their
“economic and security risks” posed by certain Chinese companies engaged in “sensitive” industries. Given
that a substantial portion of our customers are U.S. pharmaceutical and biotechnology companies, the
demands of our services are significantly influenced by U.S. government’s attitude towards Chinese service
providers in such industries. We cannot assure you that we will not be negatively influenced by the
increasing trade tensions between the U.S. and China as well as by adverse changes in U.S. laws and
regulations towards diplomatic relations. As a result, our business, financial condition, results of operations
and prospects could be materially and adversely affected.

We may not be successful in developing, enhancing, adapting to or acquiring new technologies.

We operate in a market that evolves constant developments and we must keep pace with new technologies
and methodologies to maintain our competitive position. It is critical for us to continue investing significant
amounts of human and capital resources to develop or acquire new technologies in order to enhance the
scope and quality of our services. We may also decide to continue expanding our business by entering into
new markets and new geographic areas, and therefore may need to develop or adapt to new technologies
and methodologies. We cannot assure you that we will be able to develop, enhance or adapt to new
technologies and methodologies in a timely manner or at all. Any failure to do so could stagnate or even
significantly reduce demand for our services and harm our business and prospects.

Furthermore, developing and marketing our new technologies and methodologies successfully requires us
to accurately assess and meet customers’ needs, make significant capital expenditures, optimize our drug
discovery, development and manufacturing process to predict and control costs, hire, train and retain
qualified personnel, obtain required regulatory clearances or approvals, increase customer awareness and
acceptance of our services, provide high-quality services in a timely manner, price our services
competitively, integrate innovations into our existing system and effectively incorporate customer feedback
into our business planning. If there is insufficient demand for our new technologies or methodologies, our
business, financial condition, results of operations and prospects could be materially and adversely affected.

In addition, alternatives to our services might be introduced to our current and potential customers through
technology innovations. This could reduce or even eliminate the demand for our services at all. Our failure
to develop, introduce or enhance our services’ ability to compete with new technologies in a cost-effective
and timely manner could have a material adverse effect on our business, financial condition, results of
operations and prospects.

If our service quality does not meet our customers’ evolving needs, or if we fail to meet our customers’
audit and inspections, our customers may not continue to purchase our services.

We believe service quality and customer satisfaction are among the most important factors for our business
growth today. In order to deliver quality services, it is critical to understand and take actions to fulfill the
customer’s expectation and adapt to the customers’ evolving needs. We believe our strong execution
capabilities and quality services are widely recognized by our customers. However, we cannot assure you
that we will always be able to deliver quality services that meet our customers’ evolving needs. If our
customers determine that their expenditures on our services do not generate expected results, they may
allocate a portion or all of their budgets to our competitors, and reduce or terminate their business with us.
Therefore, we cannot assure you that customers that have utilized our services in the past will continue to


                                                      36
spend at similar levels, or that they will continue to use our services at all in the future. We may not be able
to replace customers which decrease or cease their purchase of our services with new customers that spend
at similar levels or more on our services. As a result, we may suffer from a loss of customers and our ability
to maintain and/or grow our revenues will be materially and adversely affected.

Furthermore, our customers are entitled to, during normal business hours, review our standard operating
procedures and records pertaining to our services and inspect the facilities used to render our services to
such customers. We cannot assure you that we will be able to pass all such customer audits and inspections.
Failure to pass any of such audits or inspections to our customers’ satisfaction could significantly harm our
reputation and result in the termination of ongoing drug discovery and development projects by our
customers, which could materially and adversely affect our business, financial condition, results of
operations and prospects.

Our customer agreements may contain provisions that run counter to our interests or expose us to
potential liability.

Our service agreements generally provide that a customer can terminate the agreement or any work order
under the agreement without cause by giving prior written notice. Most of our project-based service
contracts also allow customers to unilaterally terminate the contract without cause by giving prior written
notice. If a customer terminates a work order or project-based service contract without cause, typically we
are only entitled to receive service fees earned up to the date of termination, costs already incurred or
irrevocably committed and in some cases a limited amount of penalty. Therefore, cancelation or
modification of a large work order or project-based service contract, or proximate cancelation or
modification of multiple smaller work orders or project-based service contract, could materially and
adversely affect our business, financial condition, results of operations and prospects.

In addition, some of our service agreements and project-based service contracts contain exclusivity clause
which prohibits us from working for other parties on certain projects. Such restriction typically remains
effective for a number of years after the relevant service agreement or project-based service contract is
completed, and in some cases is effective for an indefinite period. For some customers, the exclusivity
clause covers a broad range of products. Complying with such exclusivity clause restricts our ability to
obtain new projects and adversely affects the extent to which other customers or potential customers use
our services, a failure to do so could significantly harm our business and reputation, as well as expose us
to liability for breach of contract.

We are subject to risks inherent in international operations.

We operate a multinational business, primarily in China, the U.S. and the U.K. We intend to continue to
expand our presence globally. Our success in providing services internationally and competing in
international markets is subject to our ability to manage various risks and difficulties, including, but not
limited to:

     our ability to effectively manage our employees at remote locations or in different business
     environments from China, the U.S. and the U.K.;

     our ability to develop and maintain relationships with customers, suppliers across the countries and
     regions we operate in;

     compliance with product safety requirements and standards that are different from those of China, the
     U.S. or the U.K.;

     variations and changes in laws applicable to our operations in different jurisdictions;

     trade restrictions, political changes, disruptions in financial markets, and deterioration of economic
     conditions;


                                                      37
     customs regulations and the import and export of goods and raw materials;

     the ability to provide sufficient levels of technical support in different locations;

     our ability to effectively communicate internally and with our customers across different cultures;

     our ability to obtain and renew licenses that may be needed in international locations to support
     operations; and

     changes in tariffs, taxes, and foreign currency exchange rates.

Our profitability and ability to implement our business strategies, maintain market share and compete
successfully in international markets may be compromised if we are unable to manage these and other
international risks successfully.

We have undertaken a series of offshore acquisitions, and may undertake further acquisitions in the
future. These acquisitions may not be successful, may negatively impact our financial condition, and we
may fail to integrate such acquisitions successfully, or may be adversely affected by regulatory or
governmental scrutiny of the target countries.

In order to expand our operations and global presence, we have undertaken a series of offshore acquisitions
in the past. Between 2018 and 2021, we acquired certain of our subsidiaries in the U.S. and the U.K. to
acquire cutting-edge technologies and to expand our capabilities and service offerings through these
world-class development facilities. For example, we acquired Absorption Systems in November 2020 and
launched U.S. laboratory services through such acquisition. U.S. laboratory services mainly includes
DMPK/ADME and bioanalysis for both small and large molecules, particularly in transporters, human PK
prediction and translational pharmaceutics. In addition, we acquired Allergan Biologics Limited in April
2021 and we expect the newly acquired facilities will be highly synergistic to Absorption Systems for
building our integrated CGT services platform. We are devoting significant resources to integrating our
operations following such acquisitions in order to achieve the anticipated synergies and benefits. We may
also undertake additional offshore and/or onshore acquisitions to further develop our business. As of the
date of this Offering Circular, we had not yet identified any specific acquisition target.

The integration of our acquired subsidiaries or any future acquisitions may expose us to certain risks, such
as the incurrence of anticipated and unforeseen costs, expenses and liabilities (including latent or potential
liabilities that relate to the time prior to our acquisitions), difficulties in integrating the acquired business
in a timely and cost-effective manner or maintaining standard control policies and procedures across our
businesses, difficulties in establishing effective management information and financial control systems, and
unforeseen legal, regulatory, contractual or other issues. Furthermore, our potential acquisitions in the
future may be adversely affected by regulatory or governmental scrutiny of the target countries. If we fail
to successfully integrate recent and potential future acquisitions, or if we encounter any difficulties due to
tightened regulatory or governmental scrutiny from targeted countries, there may be an adverse effect on
our business, financial condition and results of operations.

Changes to U.S. foreign investment and export control laws and regulations may restrict our ability to
undertake acquisitions, or acquire technologies and assets in the United States that are material to our
commercial success.

Foreign investments in U.S. companies and exports of technology and technical data from the U.S.
(including disclosures of technology and technical data to foreign persons in the United States) are
potentially subject to restrictions under U.S. laws and regulations. The United States enacted the Foreign
Investment Risk Review Modernization Act of 2018 (“FIRRMA”) and the Export Control Reform Act of
2018 (“ECRA”), which together made significant changes to this legal framework. In general, FIRRMA
broadened the authorities of the President of the U.S. and the Committee on Foreign Investment in the
United States (“CFIUS”) to determine whether foreign investments present a threat to U.S. national


                                                       38
security, and to impose restrictions on or to block such investments. FIRRMA and ECRA also established
new authorities to identify “emerging” or “foundational” technologies that should be subject to greater
foreign investment and export controls. The U.S. administration is currently engaged in rulemakings to
implement the requirements of these statutes.

As an initial step, effective in November 2018, CFIUS instituted a pilot program (“Pilot Program”)
applicable to certain foreign investments in U.S. businesses that (i) are involved in “critical technologies”
and (ii) are classified within one of 27 industry sectors defined by North American Industry Classification
System code numbers (“Pilot Program U.S. Businesses”). In addition, in December 2018, the U.S.
Department of Commerce initiated a rulemaking process, required by ECRA, to identify “emerging” and
“foundational” technologies, and to impose appropriate export controls on items so identified. The Pilot
Program rules also deem such technologies to be “critical technologies.” The U.S. agencies are continuing
the rulemaking processes to implement FIRRMA and ECRA.

Businesses of our U.S. customers, or our recent or potential acquisition and investment targets may have
“critical technology,” and they may fall within NAICS 541714 (“Research and Development in
Biotechnology (except Nanobiotechnology)”) or one of the other Pilot Program specified sectors. Our
ability to make future strategic investments in, or undertake any future acquisitions of, biotechnology
companies in the United States may be adversely impacted if such a company is a Pilot Program U.S.
Business (or if it otherwise possesses export-controlled technology). Any such negative impaction may
detrimentally affect our capability to acquire foreign companies or foreign technologies or assets in the
United States that may be material to our commercial success.

We are subject to the laws and regulations with respect to our business operations in the U.S. and the
U.K.

We are required to fulfill the respective legal and regulatory requirements for our operations in the U.S. and
the U.K. For instance, all laboratory testing (except for research purposes) performed on humans in the U.S.
are regulated through the Clinical Laboratory Improvement Amendments, and our laboratories are subject
to licensing requirements and regulations under federal, state and local laws relating to, among others,
occupational safety and health and controlled substances. Failure to comply with any of the legal and
regulatory requirements may result in material impact on our operations in the relevant jurisdictions. We
are also required to hold a number of permits and licenses to carry on our business in the U.S. and the U.K.
Our ability to obtain and maintain these regulatory approvals is subject to any future changes to the
applicable U.S. and U.K. laws and regulations may place additional burden on us and have a material impact
on our operations in these countries.

If we are unable to maintain the confidentiality of our trade secrets, our business and competitive
position may be harmed.

In addition to the protection afforded by our registered intellectual property, we rely upon unpatented trade
secret protection, unpatented know-how and continuing technological innovation to develop and maintain
our competitive position. However, trade secrets and know-how can be difficult to protect. We also seek to
protect our proprietary technologies and processes, in part, by entering into confidentiality agreements with
parties that have access to them, such as our employees and certain other third parties, and invention
assignment agreements with our employees. We cannot guarantee that we have entered into such agreements
with each party that may have or have had access to our trade secrets or proprietary technologies and
processes. Furthermore, we may not be able to prevent the unauthorized disclosure or use of our technical
know-how or other trade secrets by the parties to these agreements, however, despite the existence generally
of confidentiality agreements and other contractual restrictions. If any of our employees and certain other
third parties who are parties to these agreements breaches or violates the terms of any of these agreements
or otherwise discloses our proprietary information, we may not have adequate remedies for any such breach
or violation, and we could lose our trade secrets as a result, which could materially and adversely affect our
business and competitive position. Enforcing a claim that a third party illegally disclosed or
misappropriated our trade secrets, including through intellectual property litigation or other proceedings, is
difficult, expensive and time consuming, and the outcome is unpredictable.


                                                      39
We may face potential liabilities arising from our services.

We typically undertake to defend, indemnify and hold our customers harmless from and against any
liabilities and damages (including attorneys’ fees) resulting from any third party claims, demands, suits or
proceedings to the extent arising out of our performance of services, or relating to our negligence or willful
misconduct, or breach of the service agreements. In particular, we may face product liability risks if the
pharmaceuticals we help discover, test, develop or manufacture are subject to product liability claims. Our
liability is not always capped under our service agreements, and in certain cases, the product liability cap
is not applicable for claims relating to personal injuries or death. We provide services in the discovery,
testing, development of pharmaceuticals and manufacturing of drug APIs and formulations that are intended
ultimately to be used on humans, either during clinical trials or as marketed products. Although we do not
commercially market or sell these products to end users, if any of these drugs harms people due to our
negligence, willful misconduct or material breach, we may be subject to litigations and may be required to
pay damages to our customers. Damages awarded in a product liability action could be substantial and our
insurance coverage may be inadequate or may become unavailable on terms acceptable to us.

The discontinuation of any of government incentives or preferential tax treatment currently available to
us could adversely affect our results of operations, cash flow and prospects.

During the three years ended December 31, 2020, we have benefited from government incentives. For the
years ended December 31, 2018, 2019 and 2020, we recorded under other income RMB22.7 million,
RMB35.0 million and RMB45.5 million of government grants and subsidies, respectively.

We had enjoyed preferential tax treatment during the three years ended December 31, 2020. For example,
some of our subsidiaries have obtained the high and new technology enterprise or advanced technology
enterprise accreditation and, accordingly, were entitled to a preferential income tax rate of 15% during the
three years ended December 31, 2020.

Our eligibility to receive these financial incentives requires that we continue to qualify for them. The
incentives are provided to us at the discretion of the central government or relevant local government
authorities, which could determine at any time to eliminate or reduce these financial incentives, generally
with prospective effect. Since our receipt of the financial incentives is subject to periodic time lags and
changing government practice, as long as we continue to receive these financial incentives, our net income
in a particular period may be higher or lower relative to other periods depending on the potential changes
in these financial incentives in addition to any business or operational factors that we may otherwise
experience. The discontinuation of financial incentives currently available to us could have a material
adverse effect on our financial condition, results of operations, cash flows and prospects.

Changes in laws, government regulations or in practices relating to the pharmaceutical and
biotechnology industries could decrease demand for the services we provide, and compliance with new
regulations may result in additional costs.

The markets that our customers operate in are heavily regulated, including the U.S., the U.K. and China.
Changes in laws, regulations or in practices relating to the pharmaceutical and biotechnology industries,
such as a relaxation in regulatory requirements, or the introduction of simplified drug approval procedures
that lower the entry barrier for potential competitors, or changes in regulatory requirements may make our
services less competitive, could eliminate or substantially reduce the demand for our services. Since 2016,
there has been a significant rise in outsourcing opportunities in China as a result of significant regulatory
challenges. In particular, in February 2016, the State Council issued the Opinion on Carrying out the
Quality and Efficacy Consistency Evaluation of Generic Drugs (
                   ) (the “Consistency Evaluation Opinion”). The Consistency Evaluation Opinion,
combined with other regulatory changes introduced at approximately the same time, subsequently led to a
significant increase in demand for high quality CRO services in China. However, we cannot assure you that
there will be no adverse regulatory changes in the PRC, or the regulatory changes in the PRC that have
benefitted our business during the three years ended December 31, 2020 will continue to benefit our
business going forward or that size of the CRO and CMO services market globally and in the PRC will
increase at the rate anticipated. Any of these events may have a material adverse effect on our business,
financial condition and results of operations.


                                                     40
In addition, under current regulatory requirements of the PRC, in order to introduce a drug approved
overseas into the PRC market, such drug must be registered as an imported drug, otherwise the development
process of such drug must be repeated in the PRC, either of which could take several years of work. By
engaging us, pharmaceutical and biotechnology companies are able to conduct parallel development of
drugs for both the PRC and overseas markets simultaneously. If the PRC ever streamlines, expedites or
simplifies its regulatory procedures, certain of our customers’ demand for our services may decrease, which
would have a material adverse effect on our business, financial condition and results of operations.

We have made significant capital investments to construct new facilities in China. We may face a variety
of risks associated therewith and may not be able to realize our anticipated returns.

We have constructed and will continue to construct a number of additional facilities in China to further
expand our business. Construction of new facilities, particularly for usage in the pharmaceutical and
biotechnology industry, is a complex and challenging process. Among other things, it requires interpretation
of and compliance with many laws, codes, and regulations; gathering of considerable resources, including
labor, equipment, and material; and communications with and coordination among multiple parties, which
could divert resources from our productive uses and consume significant amounts of management time.
Furthermore, it’s not uncommon for construction projects to run longer than expected or exceed original
cost budgets, and we cannot assure you that we will be able to develop and deploy an appropriate plan for
managing those risks. Construction delays or failure to complete the construction of a property development
project according to its planned specifications, schedule or budget as a result of the above or any other
factors may have a material adverse effect on our business, financial condition and results of operations.

We have made and will continue to make significant capital expenditures in constructing our facilities. Our
capital expenditures amounted to RMB641.0 million, 754.6 million and RMB1,315.8 million for the years
ended December 31, 2018, 2019 and 2020, respectively. We expect that our business will further grow with
our new facilities. However, if our business does not grow at the pace as we expected, we may not be able
to generate sufficient revenue and profit to cover our capital expenditures in constructing facilities, and our
business, financial position and results of operations may be materially and adversely affected.

If we are unable to successfully expand or operate in new geographic markets, our business and
prospects may be adversely affected.

During the three years ended December 31, 2020, we generated a significant portion of our revenue from
customers headquartered in the U.S. We intend to further diversify our customer geographic mix to increase
revenue generated by customers headquartered in China, the U.K. and other countries or regions. However,
the legal and regulatory systems, competitive landscapes and customer preferences of these markets may
be different from the markets in which we currently operate. We have limited experience working with
customers in markets other than the U.S., the U.K. and China, and we may encounter unanticipated barriers
and challenges in these new markets, which may result in a delay to or failure of our expansion plans. In
addition, we may invest significant time and resources in promoting brand awareness and acquiring market
shares in these new markets. We may not be able to manage our costs or generate sufficient revenue to
justify the time and resources spent. If our geographic expansion is unsuccessful, our business operation and
financial condition could be materially and adversely affected.

Payment delay or failure by our customers could adversely affect our cash flows and profitability.

We aim to trade solely with recognized and creditworthy third parties, and all of our customers who intend
to trade on credit terms are subject to our credit verification procedures. As of December 31, 2018, 2019
and 2020, our trade receivables (net of allowance for impairment) were RMB604.0 million, RMB857.1
million and RMB1,076.6 million, respectively. If any of our customers’ business, cash flow, conditions or
results of operations deteriorates, it may be unable or unwilling to pay trade receivables owed to us
promptly or at all. Moreover, we are also subject to credit risk arising from unbilled revenue (i.e., our
contract assets) or the risk that a Group’s customer may not pay in accordance with the terms of the agreed
payment schedule once the amount has been billed. As of December 31, 2018, 2019 and 2020, our contract
assets (net of allowance for impairment) were RMB51.1 million, RMB89.1 million and RMB133.8 million,


                                                      41
respectively. We may not be able to bill all or any of the contract assets to our customers, or may not be
able to bill such customers within the expected timeline. In addition, any substantial default or delay of a
customer’s payment obligations may materially and adversely affect our working capital, financial
condition and results of operations.

Increased labor and staff costs could affect our growth and profitability.

Our operations require a sufficient number of experienced and qualified employees. Our labor and staff
costs accounted for approximately 43.3%, 41.8% and 43.8% of our revenue for the years ended December
31, 2018, 2019 and 2020, respectively. The labor market for trained scientists and other qualified staff with
suitable experience is highly competitive and we may need to pay more in salaries, benefits in kind or
retirement benefits in order to recruit and retain appropriate staff. We may also need to recruit additional
personnel to enhance our internal control, financial reporting and compliance functions after the Listing. We
cannot assure you that our labor costs will not continue to increase. If there is a significant increase, our
business, financial condition and results of operations may be adversely affected.

We depend on a stable and adequate supply of quality raw materials from our suppliers, and price
increases or interruptions of such supply could have an adverse impact on our business.

Our operations require a stable and adequate supply of quality raw materials. Although we believe that we
have stable relationships with our existing suppliers, we cannot assure you that we will always be able to
secure a stable supply of qualified raw materials going forward. Our suppliers may not be able to keep up
with our fast-growing business, may not be able to adapt to new technologies and methodologies to produce
qualified raw materials, or may reduce or discontinue their supply of raw materials to us at any time. In
addition, we cannot assure you that our suppliers have obtained and will be able to renew all licenses,
permits and approvals necessary for their operations or comply with all applicable laws and regulations, and
failure to do so may lead to interruptions to their business operation, which in turn may result in a shortage
of raw materials supplied to us. If the supply of quality raw materials to us is interrupted, our business
operation and financial position may be adversely affected.

We may not be able to effectively manage our inventory levels.

Our inventories include raw materials and consumables used for our service. We manage our inventory
levels based on our forecasts of customer demand for our services in terms of ongoing projects and potential
new projects. Customer demand, however, can be affected by numerous uncertainties, including in relation
to the progress of their projects, pending regulatory approvals, timing and success of clinical trials, our level
of success in securing new projects and other factors beyond our control. Our inventories amounted to
RMB70.1 million RMB97.1 million and RMB128.8 million as of December 31, 2018, 2019 and 2020,
respectively.

If we fail to manage our inventory levels effectively, we may be subject to a heightened risk of inventory
obsolescence, a decline in the value of inventories, and potential inventory write-downs or write-offs.
Procuring additional inventories may also require us to commit substantial working capital, preventing us
from using such capital for other purposes. Any of the foregoing may materially and adversely affect our
results of operations and financial condition.

Negative publicity may adversely affect our reputation, business and growth prospects.

Any negative publicity concerning us, our affiliates or any entity that shares the “Pharmaron” name, even
if untrue and inauthentic, could adversely affect our brand image, reputation, business and prospects,
particularly in light of our specialized customer base, customer referrals and word-of-mouth marketing are
particularly important to our ability to acquire customers. Damage to our reputation could be difficult,
expensive and time-consuming to restore and could make it challenging for us to retain our existing
customers or attract new customers and could adversely affect our recruitment and retention efforts.
Damage to our reputation could also reduce the value and effectiveness of our brand name and could reduce
investor confidence in us, adversely affecting the price of our Shares.


                                                       42
We may be subject to intellectual property infringement claims or other relevant disputes, which could
expose us to substantial liability and harm our reputation.

We may be exposed to intellectual property right infringement or misappropriation claims by third parties
when we develop and use any of our own technology, know-hows and brand. As of December 31, 2020, we
had not received any notices of material claims or complaints against us for intellectual property
infringement. However, we cannot assure you that we will not be subject to any such intellectual property
rights claims in the future. Although we plan to defend ourselves vigorously in any such litigations or legal
proceedings, we cannot assure you that we will prevail in these matters. Even if we were to succeed in our
defense, involvement in such litigations and legal proceedings may also cause us to incur substantial
expenses and divert the time and attention of our management. An adverse determination in any such
litigations or proceedings could subject us to significant liability to third parties, require us to obtain
licenses from third parties, pay ongoing royalties, or subject us to injunctions prohibiting the distribution
and marketing of our services. Any similar claim against us, even without any merit, could also damage our
reputation and brand image. Any such event could have a material and adverse effect on our business,
financial condition and results of operations.

We typically undertake to defend, indemnify and hold our customers harmless from and against any
liabilities and damages (including attorneys’ fees) resulting from any third party claims, demands, suits or
proceedings to the extent arising out of our performance of services, or relating to our negligence or willful
misconduct, or breach of the service agreements. As a result, if any aspect of a deliverable to a customer
that we create infringes a third party’s intellectual property rights due to our gross negligence, and
particularly if such deliverable ultimately becomes a commercially successful product, we could be exposed
to substantial liability. Any material intellectual property infringement claim, if raised against us, could
have a material adverse impact on our reputation, business, financial condition and results of operations.

If we fail to protect our intellectual property rights, we may lose our competitive edge and our brand
image, reputation and prospects may be materially and adversely affected.

Unauthorized use of any of our intellectual property rights may materially and adversely affect our business
and reputation. We are endeavored to protect our intellectual property rights by various means including
registering our trademarks, copyrights and patents and filing patent applications in accordance with
applicable laws and regulations both in China, the U.S. and worldwide. Nevertheless, third parties may
obtain and use our intellectual property rights without due authorization. The validity, enforceability and
scope of protection available under the relevant intellectual property laws in the PRC are uncertain and still
evolving. Implementation and enforcement of PRC intellectual property-related laws have historically been
incomplete and ineffective. Accordingly, the intellectual property and confidentiality legal framework in
China may not afford protection to the same extent as in the United States or other countries. The experience
and capabilities of PRC courts in handling intellectual property litigation varies, and outcomes are
unpredictable. Further, such litigation may require a significant expenditure of cash and may divert our
management’s attention from our operations, which could harm our business, financial condition and results
of operations. An adverse determination in any such litigation could materially impair our intellectual
property rights and may harm our business, prospects and reputation.

In addition, we may encounter significant problems in protecting and defending our intellectual property
rights in foreign jurisdictions. The legal systems of certain countries, particularly certain developing
countries, do not favor the enforcement of patents, trade secrets, and other intellectual property protection,
particularly those relating to biotechnology products, which could make it difficult for us to stop the
infringement of our intellectual property rights and proprietary rights generally. Proceedings to enforce our
intellectual property rights and proprietary rights in foreign jurisdictions could result in substantial costs
and divert our management’s efforts and attention from other aspects of our business, could put our patents
and other intellectual property rights at risk of being invalidated or interpreted narrowly, could put our
patent applications at risk of not being approved, and could provoke third parties to initiate counterclaims
against us. We may not prevail in any lawsuits that we initiate, and the damages or other remedies awarded,
if any, may not be commercially meaningful and sufficient. Accordingly, our efforts to enforce our
intellectual property rights and proprietary rights around the world may be insufficient to obtain a
significant commercial advantage from the intellectual property that we develop or license.


                                                     43
We may be exposed to risks related to our management of the medical data of subjects enrolled in our
clinical trials.

During the clinical trials, we routinely collect and maintain medical data treatment records and other
personal details of enrolled subjects. We are subject to the relevant privacy laws and regulations of the
various jurisdictions in which we conduct our clinical trials. Although we have taken measures to maintain
the confidentiality of the medical records and personal data of subjects enrolled in our clinical trials,
including encrypting such information in our information technology system so that it cannot be viewed
without proper authorization, and setting internal rules requiring our employees to maintain the
confidentiality of our subjects’ medical records, we cannot assure you that such measures are effective in
ensuring compliance with the relevant laws and regulations or that we are able to prevent the enrolled
subjects’ private or medical records being divulged without their consent. For example, our information
technology systems could be hacked, and personal information could leak due to theft or misuse of personal
information arising from misconduct or negligence. In addition, our clinical trials frequently also involve
professionals from third party institutions working on-site with our staff and enrolled subjects. We cannot
ensure that such persons will always comply with our data privacy measures. Furthermore, any change in
such laws and regulations could affect our ability to use medical data and subject us to liability for the use
of such data for previously permitted purposes. Any failure to protect the confidentiality of subjects’
medical records and personal data, or any restriction on or liability as a result of our use of medical data,
could have a material adverse effect on our business, financial condition and results of operations.

We may fail to effectively develop and market new services, which may harm our growth opportunities
and prospects.

We intend to continue expanding our service offerings. For example, we plan to expand our services into
later stage clinical studies and commercial manufacturing to further strengthen our fully-integrated
pharmaceutical R&D service platforms and to build and expand our capabilities for biologics. To develop
and market our new services successfully, we must accurately assess and meet customer needs; make
significant capital expenditures; optimize our discovery, testing, development and manufacturing process,
predict and control costs; attract, train and retain the necessary personnel; obtain required regulatory
clearances or approvals; increase customer awareness and acceptance of our services; provide services of
a high quality and in a timely manner; price our services competitively; compete successfully with other
research and development outsourcing providers and effectively incorporate customer feedback into our
business planning. If we fail to effectively develop new services and create demand for them, our future
business, including results of operations, financial condition, cash flows and prospects, could be materially
and adversely affected.

If we lose any of our key customers, our business and results of operations may be adversely affected.

We have a large, diverse and loyal customer base which includes all of the top 20 global pharmaceutical
companies and many reputable biotechnology companies, according to Frost & Sullivan. For the years
ended December 31, 2018, 2019 and 2020, our top five customers accounted for 24.8%, 21.1% and 18.8%
of our revenue, respectively, and our largest customer accounted for 5.7%, 5.3% and 6.0% of our revenue,
respectively. We cannot assure you that we will be able to maintain or strengthen our relationships with our
key customers, or that our key customers will continue to engage us for significant service contracts.
Furthermore, we may not be able to realize all of the anticipated future revenue associated with our
contracted future revenue, particularly our clinical trial service contracts and CMC (small molecule CDMO)
service contracts. If there is any significant cutback in spending for our pharmaceutical R&D services by
our key customers due to industry consolidation, deterioration of their financial conditions, research and
development budget cuts, pending regulatory approvals or other reasons and we are unable to obtain
suitable service contracts of comparable size and terms as replacement, our business, financial condition
and results of operations may be materially and adversely affected.



                                                     44
If we fail to comply with applicable anti-bribery and anti-corruption laws, our reputation may be harmed
and we could be subject to penalties and significant expenses.

We are subject to the anti-bribery laws of the jurisdictions in which we operate, particularly the U.S., China
and the U.K. In the U.S., the Foreign Corrupt Practices Act of 1977 generally prohibits a company from
making improper payments, directly or indirectly, to foreign officials for the purpose of obtaining or
retaining business. Further, in the U.S., the Bank Secrecy Act, as amended by Title III of the Uniting and
Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act
of 2001 (USA Patriot Act), prohibits money laundering and any activities that could facilitate money
laundering. In China, the Anti-Unfair Competition Law, and provisions of the Criminal Code, prohibit
giving and receiving money or property (which includes cash, proprietary interests and items of value) to
obtain an undue benefit. Further, in China, Anti-Money Laundering Law of the People’s Republic of China
(                          ), promulgated by the Standing Committee of the National People’s Congress on
October 31, 2006 and effective on January 1, 2007, prohibits money laundering. Our operations in the U.K.
may also subject us to various anti-bribery laws and regulations, including the United Kingdom’s Bribery
Act of 2010 which prohibits commercial bribery and makes it a crime for companies failing to prevent
bribery. In addition, many of our customers require us to follow strict anti-bribery and anti-money
laundering policies as part of doing business with us. Our procedures and controls to monitor anti-bribery
and anti-money laundering compliance may fail to protect us from reckless or criminal acts committed by
our employees or agents. If we fail to comply with applicable anti-bribery laws and anti-money laundering,
our reputation could be harmed, customers could cancel or not renew contracts for our services and we
could incur criminal or civil penalties, other sanctions and significant expenses, which could have a material
adverse effect on our business, financial condition and results of operations.

We may incur additional expenses if we are forced to relocate due to title defects of some of our leased
properties.

As of December 31, 2020, we have not obtained a valid property ownership certificate from a lessor of
certain properties we leased in the PRC. As a result, the lease agreement may be challenged as to its validity.
If the lease agreement is deemed to be invalid by the relevant PRC authorities or if the lessor does not
possess valid titles, we may not be able to continue to lease such property and be forced to relocate, which
may cause our business, financial condition and results of operations to be adversely affected.

We recorded net current liabilities as of December 31, 2018. We cannot assure you that we will not
experience net current liabilities in the future, which could expose us to liquidity risks.

We recorded net current liabilities of RMB31.9 million as of December 31, 2018. Such net current liabilities
position was primarily due to a RMB156.3 million increase in other payables and accruals in connection
with our staff payroll and the construction of our Ningbo facilities, a RMB67.8 million increase in
short-term interest-bearing bank and other borrowings as some long term borrowings would mature within
one year and were classified as current liabilities and a RMB80.2 million increase in contract liabilities as
a result of the strong demand for our services, partially offset by a RMB109.1 million increase in trade
receivables and a RMB46.1 million increase in prepayments, other receivables and other assets as of
December 31, 2018. We did not record net current liabilities as of December 31, 2019 or 2020.

We cannot assure you that we will not record net current liabilities again in the future. A net current
liabilities position exposes us to liquidity risks. Our future liquidity, the payment of trade and other
payables and the repayment of debt financing will primarily depend on our ability to generate adequate cash
inflows from our operating activities. If we experience a shortage in cash flow generated from operations,
our liquidity position may be materially and adversely affected, which, in turn, may impact our ability to
execute our business strategies. If such event occurs, our results of operations and financial position will
be materially and adversely affected.



                                                      45
We may be subject to administrative penalty for our failure to register our leased properties in China.

As of December 31, 2020, we leased from third parties 36 properties in the PRC with an aggregate gross
floor area of over 91,295.64 sq.m. (excluding the GFA of dorm rooms leased for our employees) for our
operations, and the registrations for certain of these properties with the relevant regulatory authorities have
not been completed. According to PRC law, the non-registration of lease agreements will not affect the
validity of such lease agreements, but the relevant local housing administrative authorities can require us
to complete registrations within a specified timeframe and we may be subject to a fine between RMB1,000
and RMB10,000 per lease for any delay in making these registrations. Further, we cannot assure you that
we would be able to renew our leases on acceptable terms upon their expiration. If we are not able to renew
them upon expiration, or if relevant leases are terminated as a result of challenges therewith by third parties,
we may be forced to relocate from affected properties and incur additional costs, and our business, financial
condition and results of operations may be adversely affected.

Animal testing could result in negative attention from special interest groups with respect to our use of
laboratory animals for research purposes and adversely affect our business.

Some of our services utilize animals in the testing of the safety and efficacy of pharmaceuticals, including
non-human primates. The use of laboratory animals at our facilities must be conducted in compliance with
applicable laws and regulations in the jurisdictions in which those activities are conducted. If an
enforcement agency determines that our equipment, facilities, laboratories or processes do not comply with
applicable standards, it may issue an inspection report documenting the deficiencies and setting deadlines
for any required corrective actions. For non-compliance, the agency may take action against us that may
include fines or confiscation of laboratory animals. Any such non-compliance with legal, regulatory or
third-party accreditation requirements may also result in the limitation, termination, suspension or
revocation of any licenses, permits, authorizations, assurances, certificates or accreditations necessary for
the conduct of our business. Any determination of non-compliance, report or other action by an enforcement
agency could adversely affect our business, financial condition and results of operations. Furthermore,
contaminations in our animal populations may damage our inventory, harm our reputation and result in
decreased sales and cause us to incur additional costs.

In addition, certain special-interest groups object to the use of these animals for research purposes. Any
threats directed against our animal research activities or any negative media attention could impair our
ability to operate our business efficiently. In addition, if regulatory authorities were to mandate a significant
reduction in safety testing procedures that utilize laboratory animals, as has been advocated by certain
groups, our business could be materially and adversely affected.

We may face a variety of challenges relating to our clinical trial services.

We offer a variety of early-stage clinical trial services for our customers and intend to further expand our
services for late-stage clinical trials. We believe customers for our clinical trial services rely on us to help
them reduce costs and speed the process of bringing a drug to market. However, we face a variety of
challenges relating to our clinical trial services, including without limitation the increasingly complex
nature of regulatory requirements and variations between different regulatory bodies, challenge of focusing
on the best study design and high rate of failure to meet primary endpoints due to poor or complex design
of clinical trials, increasing costs for clinical trials, difficulties in enrolling a sufficient number of subjects
who would remain in the trial until its conclusion, the ability to develop safety oversight and medical
management plans as well as trial monitoring plans for the clinical trials, and the ability to keep up with
continuous development of technologies. We may face any or even all of the aforementioned challenges and
other challenges and risks inherent to clinical trials. If we fail to develop appropriate plans to deal with such
challenges, we may not be able to deliver effective clinical trial services to our customers, and our business,
results of operations and prospects may be materially and adversely affected.



                                                        46
Our insurance coverage may not be sufficient.

We maintain certain insurance policies to safeguard against certain risks and unexpected events, such as
property insurance and general commercial liability and professional errors and omissions insurance. We
consider our insurance coverage to be in line with what we believe to be customary practice in our industry.
For more details, please refer to the paragraph headed “Description of the Group–Insurance” in this
Offering Circular. However, we cannot assure you that our insurance coverage in terms of amount, scope
and benefit is sufficient. In addition, the insurance industry in China is still at an early stage of
development. Insurance companies in China generally offer limited business-related insurance products and
such products typically command a high premium that may not be justifiable from a cost benefit
perspective. We do not have any business disruption insurance, product liability insurance or key-man life
insurance. Therefore, we are exposed to various risks associated with our business and operations. Such
risks include, among others, loss of key management and personnel, business interruption, litigation or legal
proceedings, natural disasters such as epidemics, pandemics or earthquakes, terrorist attacks and social
instability or any other events beyond our control. Our business, financial condition and results of
operations may be materially and adversely affected as a result.

Any future litigations, legal disputes, claims or administrative proceedings against us could be costly and
time-consuming.

We may, from time to time, become subject to legal proceedings and claims that arise in the ordinary course
of business or as a result of governmental or regulatory enforcement activity. While we do not believe that
the resolution of any lawsuits against us will, individually or in the aggregate, have a material adverse effect
on our business, financial condition and results of operations, any litigation to which we subsequently
become a party might result in substantial costs and divert management’s attention and resources.
Furthermore, any litigations, legal disputes, claims or administrative proceedings which are initially not of
material significance may escalate and become significant to us due to a variety of factors, such as the facts
and circumstances of the cases, the likelihood of loss, the monetary amount at stake and the parties
involved.

Our insurance might not cover claims brought against us, might not provide sufficient payments to cover
all of the costs to resolve one or more such claims and might not continue to be available on terms
acceptable to us. In particular, any claim could result in unanticipated liability to us if the claim is outside
the scope of the indemnification agreements we have entered into with our customers, if our customers do
not abide by the indemnification arrangement as required, or if the liability exceeds the amount of any
applicable indemnification limits or available insurance coverage. A claim brought against us that is
uninsured or underinsured could result in unforeseen costs and could have a material adverse effect on our
financial condition, results of operations or reputation.

Our facilities are vulnerable to natural disasters or other unforeseen catastrophic events.

We conduct our business primarily at our facilities located in China, the U.S. and the U.K. We depend on
these facilities for our business operations. Natural disasters or other unanticipated catastrophic events,
including power interruptions, water shortage, storms, fires, earthquakes, terrorist attacks and wars could
significantly impair our ability to operate our business in ordinary course. Our facilities and certain
equipment located in these facilities would be difficult to replace in any such event and could require
substantial replacement costs and time. The occurrence of any such event may materially and adversely
affect our business, financial condition, results of operations and prospects.

We rely on our information technology system and may face security risks, including cyber security risks.

We rely on a variety of information technology and automated operating systems to manage and support our
operations, including protecting our customers’ intellectual property and managing and storing our
operating data. The proper functioning of these systems is critical to the efficient operation and management
of our business. In addition, these systems may require modifications or upgrades as a result of


                                                      47
technological changes or development in our business. These changes may be costly and disruptive to our
operations and could divert our management’s attention and resources. Our systems, and those of third-party
providers that we engage, may be vulnerable to damage or disruption caused by circumstances beyond our
control, such as catastrophic events, power outages, natural disasters, computer system or network failures,
viruses or malware, physical or electronic break-ins, unauthorized access, cyber-attacks and thefts. We
cannot assure you that the measures and steps we take to secure our systems and electronic information are
sufficient. Any significant disruption to our systems could result in unauthorized disclosure of confidential
information and adversely affect our business and results of operation.

Some of our service contracts are contingent on successful completion of mutually agreed milestones,
and we may bear financial risks related to our failures to accomplish such milestones on schedule.

We generate fee income primarily for the services we provide. Under certain of our project-based contracts
or work orders, we recognize revenue upon completion of milestones, either in the form of pre-set steps,
delivery and acceptance of the study results and/or other deliverables or critical points in the drug
discovery, development or manufacturing process. Therefore, if we fail to deliver services in accordance
with our contractual requirements, experience cost overruns or underprice these contracts due to
competitive pressures, we could be subject to significant costs or liability and our reputation could be
harmed. Furthermore, in pricing our contracts, we take into consideration the market positioning of our
services, prices of comparable services offered by our competitors, the success of the project, degree of
saturation of the current market, market trends, complexities of the services required, costs and expenses
of our services and the timeline of the contract. However, our evaluation of these factors may be inaccurate
or incorrect. If we underprice our contracts or experience cost overruns, we may incur losses, and our
business, financial condition, results of operations, cash flows and prospects would be adversely affected.

Our equity investments/financial assets at fair value through profit or loss are subject to the uncertainties
in accounting estimates.

We measure our derivative financial instruments, equity investments at fair value through profit or loss and
financial assets and liabilities at fair value through profit or loss at their respective fair values. Fair value
is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction
between market participants at the measurement date. The fair value measurement is based on the
presumption that the transaction to sell the asset or transfer the liability takes place either in the principal
market for the asset or liability, or in the absence of a principal market, in the most advantageous market
for the asset or liability. We have adopted IFRS 9, which is effective for the period beginning on or after
January 1, 2018 throughout the three years ended December 31, 2020. The equity investments at fair value
through profit or loss is measured using the assumptions that market participants would use when pricing
such equity investments, assuming that market participants act in their economic best interest. As such, we
believe that our equity investments at fair value through profit or loss are subject to the uncertainties of
accounting estimates and therefore warrant particular attention.

All assets and liabilities for which fair value is measured are categorized within the fair value hierarchy,
described as follows, based on the lowest level input that is significant to the fair value measurement as a
whole: (i) level 1 financial assets and liabilities, which refer to quoted (unadjusted) market prices in active
markets for identical assets or liabilities, (ii) level 2 financial assets and liabilities, which refer to valuation
techniques for which the lowest level input that is significant to the fair value measurement is directly or
indirectly observable, and (iii) level 3 financial assets and liabilities, which refer to valuation techniques
for which the lowest level input that is significant to the fair value measurement is unobservable. As of
December 31, 2018, 2019 and 2020, we recorded equity investments at fair value through profit or loss of
RMB24.3 million, RMB59.1 million and RMB121.2 million, respectively, while we recorded financial
assets at fair value through profit or loss of nil, RMB169.8 million and RMB825.3 million as of December
31, 2018, 2019 and 2020, respectively.



                                                        48
We may face goodwill impairment risks in connection with our acquisitions.

In order to expand our operations and global presence, we have undertaken a series of acquisitions in the
U.S. and the U.K. to acquire cutting-edge technologies and to expand our capabilities and service offerings
through these world-class development facilities. We also acquired CR Medicon and Beijing LinkStart in
2019 and 2020 to further expand our clinical development services in China. In practice, many companies
acquire other companies and pay a consideration that exceeds the fair value of identifiable assets and
liabilities that the acquired company possesses, the difference between the purchase price and the fair value
of acquired assets is recorded as a goodwill. The carrying amount of goodwill of our Group were RMB139.9
million, RMB203.3 and RMB1,166.2 million at December 31, 2018, 2019 and 2020, respectively. Goodwill
impairment arises when there is deterioration in the capabilities of acquired companies to generate cash
flows, and the fair value of the goodwill dips below its book value. We face goodwill impairment risks in
connection with our acquisitions, and any significant goodwill impairment for our acquired companies will
adversely affect our business, financial condition and prospects.

We have intangible asset other than goodwill. If any intangible assets were determined to require
impairment, it could adversely affect our result of operations and financial position.

We have other intangible assets other than goodwill in the form of client relationship, software and patents.
As of December 31, 2018, 2019 and 2020, the carrying amounts of our other intangible assets were
approximately RMB13.9 million, RMB35.4 million and RMB190.0 million, respectively. At the end of the
reporting period, we review the carrying amounts of other intangible assets with finite useful lives to
determine whether there is any indication that those assets have suffered an impairment loss. In the event
that our other intangible assets are impaired, the amount of the impairment will constitute a non-cash
expense to the profit or loss. A slowdown in revenue growth, our inability to maintain our research and
development activities or a decrease in profit margins could result in an impairment to our other intangible
assets other than goodwill. We cannot assure that we will continue to maintain the same level of revenue
growth, research and development activities and/or profit margins. In addition, a change in the assumptions
used in the impairment testing of intangible assets may lead to significant impairment losses. If our other
intangible assets are impaired, or there is a change in the assumptions used in the impairment testing of our
other intangible assets, our results of operations could be adversely affected.

We are uncertain about the recoverability of our deferred tax assets, which may affect our financial
position in the future.

As of December 31, 2020, we had recognized a deferred tax assets of RMB8.4 million. Deferred tax assets
are generally recognized for all deductible temporary differences to the extent that it is probable that taxable
profits will be available against which those deductible temporary differences can be utilized. If we suffer
losses in the future, we may not be able to utilize all of our deferred tax assets, which could affect our
financial position in the future.

We face risks related to health epidemics or other outbreaks in countries and regions where we have
operations, including the COVID-19 outbreak.

Any future occurrence of force majeure events, natural disasters or outbreaks of epidemics and contagious
diseases, including COVID-19, avian influenza, severe acute respiratory syndrome, swine influenza caused
by the H1N1 virus, or H1N1 influenza or the Ebola virus, may materially and adversely affect our business,
financial condition and results of operations. An outbreak of an epidemic or contagious disease could result
in a widespread health crisis and restrict the business activities in affected areas, which may, in turn,
materially and adversely affect our business. For example, the outbreak of COVID-19 has affected many
people globally, caused temporary suspension of productions and shortage of labor and raw materials in
affected regions, and disrupted local and international travel and economy. The exacerbation, continuance
or reoccurrence of COVID-19 has already caused and may continue to cause an adverse and prolonged
impact on the economy, geopolitical and social conditions in China, the U.S., the U.K. and other affected
countries. The existing clinical trials and the commencement of new clinical trials could also be
substantially delayed or prevented by any delay or failure in patient recruitment or enrollment in clinical


                                                      49
trials as a result of the outbreak of COVID-19. Moreover, some of the countries and regions in which we
have operations have experienced natural disasters such as earthquakes, floods and droughts in the past few
years. Any future occurrence of severe natural disasters in any of the countries and regions in which we
have operations may materially and adversely affect its economy and our business. We cannot assure you
that any future occurrence of natural disasters or outbreaks of epidemics and contagious diseases or the
measures taken by the Chinese, U.S. and U.K. governmental authorities or other countries in response to
such contagious diseases will not seriously disrupt our operations or those of our customers, which may
materially and adversely affect our business, financial condition and results of operations.

We may need additional capital but may be unable to obtain the funding in a timely manner or on
acceptable terms or at all.

In order to further expand our capacity, develop new services, undertake desirable acquisitions and remain
competitive, we may require additional capital. We expect to satisfy such capital commitments using part
of the net proceeds from the Global Offering, cash from operations and bank facilities available to us.
Financing may be unavailable in amounts or on terms acceptable to us. Our ability to obtain additional
capital is subject to a variety of uncertainties, including our future financial condition, results of operations
and cash flows, general market conditions for capital-raising activities by CROs and CMOs, and economic,
political and other conditions in China, the U.S. and the U.K. The sale of additional equity or equity-linked
securities could result in dilution to the Shares held by our shareholders. The incurrence of indebtedness
would result in increased debt service obligations and could result in operating and financing covenants
restricting our operations or our ability to make acquisitions or pay dividends. Any failure to acquire
sufficient additional capital to meet our capital requirements may materially and adversely affect our
business, financial condition and results of operations.

RISKS RELATING TO CONDUCTING BUSINESS IN CHINA

Adverse changes in the PRC economic, political and social conditions as well as laws and government
policies, may materially and adversely affect our business, financial condition, results of operations and
prospects.

We are headquartered in Beijing, China and have a number of facilities across different provinces in China.
Accordingly, our business, financial condition and results of operations are affected to a significant degree
by the economic, political and social conditions in China. The Chinese economy differs from the economies
of most developed countries in many respects, including the amount of government involvement, level of
development, control of foreign exchange and allocation of resources, among other factors. The Chinese
government has implemented various measures to encourage, but also to control, economic growth and to
guide the allocation of resources. Some of these measures benefit the overall Chinese economy, but may
also have a negative effect on us. For example, our business, financial condition and results of operations
may be adversely affected by changes in pharmaceutical industry or tax regulations. These measures may
cause decreased pharmaceutical activity and economic activity generally in China, which in turn could
adversely affect our business, financial condition, results of operations. PRC legal system embodies
inherent uncertainties that may affect the protection afforded to our business and our Shareholders.

The PRC legal system is based on written statutes. Prior court decisions may be adduced for reference but
have limited precedential value. Since the late 1970s, the PRC government has promulgated laws and
regulations dealing with such economic matters as the issuance and trading of securities, shareholders’
rights, foreign investment, corporate organization and governance, commerce, taxation and trade, with a
view towards developing a comprehensive system of commercial law. However, as these laws and
regulations are relatively new, the effect of these laws and regulations on the rights and obligations of the
parties involved may involve uncertainty. As a result, the legal protections available to you under the PRC
legal system may be limited.



                                                       50
Our operations in the PRC are subject to PRC regulations governing PRC companies. These regulations
contain provisions that are required to be included in the articles of association of PRC companies and are
intended to regulate the internal affairs of these companies. The PRC Company Law and regulations, in
general, and the provisions for the protection of Shareholders’ rights and access to information, in
particular, may be considered less developed than those applicable to companies incorporated in Hong
Kong, the United States and other developed countries or regions. In addition, PRC laws, rules and
regulations applicable to companies listed overseas do not distinguish between minority and controlling
shareholders in terms of their rights and protections. As such, our minority shareholders may not have the
same protections afforded to them by companies incorporated under the laws of the United States and
certain other jurisdictions.

We may be restricted from transferring our scientific data abroad.

On March 17, 2018, the General Office of the State Council promulgated the Measures for the Management
of Scientific Data (                    ), or the Scientific Data Measures, which provides a broad definition
of scientific data and relevant rules for the management of scientific data. According to the Scientific Data
Measures, enterprises in China must seek governmental approval before any scientific data involving a state
secret may be transferred abroad or to foreign parties. Further, any researcher conducting research funded
at least in part by the Chinese government is required to submit relevant scientific data for management by
the entity to which such researcher is affiliated before such data may be published in any foreign academic
journal. Given the term state secret is not clearly defined, if and to the extent any data collected or generated
in connection with our services will be subject to the Scientific Data Measures and any subsequent laws as
required by the relevant government authorities, we cannot assure you that we can always obtain relevant
approvals for sending scientific data (such as the results of our pre-clinical studies or clinical trials
conducted within China) abroad or to our foreign partners in China. If we are unable to obtain necessary
approvals in a timely manner, or at all, our business, results of operations, financial conditions and
prospects may be materially and adversely affected. If the relevant government authorities consider the
transmission of our scientific data to be in violation of the requirements under the Scientific Data Measures,
we may be subject to fines and other administrative penalties imposed by those government authorities.

Changes in PRC laws and regulations on labor and employee benefits may adversely affect our business
and results of operations and substantially increase our labor-related costs.

As a substantial portion of our business is conducted through our subsidiaries in China, we are subject to
PRC laws and regulations on labor and employee benefits. In recent years, the PRC government has
implemented policies to strengthen the protection of employees and obligate employers to provide more
benefits to their employees. The PRC Employment Contract Law and the Employment Contract Regulation,
both of which became effective in 2008, require more benefits to be provided to employees, such as
compensation for termination of employment contracts. In addition, the Employment Contract Law and the
Employment Contract Regulation contain provisions that are more favorable to employees than the prior
labor laws and regulations in China. For example, an employer is obligated to compensate an employee if
the employer decides not to renew an existing employment contract, unless the employee refuses the
employer’s offer to renew the expiring employment contract with the same or better terms. In addition, an
employer is obligated to provide an open-ended employment contract after an employee has completed two
consecutive terms of fixed-term employment, under which the employer will be liable to pay damages to
an employee if the employer terminates the employment without cause, until the employee reaches an age
at which he or she is eligible for pension payment. As a result of the implementation of the Employment
Contract Law and the Employment Contract Regulation, we may have greater difficulty terminating
under-performing employees and may incur higher levels of labor costs in order to comply with the
provisions of the new law and regulation, which may adversely affect our business, financial condition and
operating results.




                                                       51
Governmental control of currency conversion, and restrictions on the remittance of RMB into and out
of the PRC, may adversely affect the value of your investment.

Some of our revenue was denominated in Renminbi during the three years ended December 31, 2020.
Renminbi is currently not a fully freely convertible currency. A portion of our revenues may be converted
into other currencies in order to meet our foreign currency obligations. For example, we need to obtain
foreign currency to make payments of declared dividends, if any, on our H Shares. Under China’s existing
laws and regulations on foreign exchange, following the completion of the Global Offering, we will be able
to make dividend payments in foreign currencies by complying with certain procedural requirements and
without prior approval from SAFE. However, in the future, the PRC government may, at its discretion, take
measures to restrict access to foreign currencies for capital account and current account transactions under
certain circumstances. As a result, we may not be able to pay dividends in foreign currencies to holders of
our H Shares.

Our operations are subject to and may be affected by changes in PRC tax laws and regulations.

We are subject to periodic examinations on fulfillment of our tax obligation under the PRC tax laws and
regulations by PRC tax authorities. Although we believe that in the past we had acted in compliance with
the requirements under the relevant PRC tax laws and regulations in all material aspects and had established
effective internal control measures in relation to accounting regularities, we cannot assure you that future
examinations by PRC tax authorities would not result in fines, other penalties or actions that could
adversely affect our business, financial condition and results of operations, as well as our reputation.
Furthermore, the PRC government from time to time adjusts or changes its tax laws and regulations. For
example, under the Individual Income Tax Law (“IIT Law”) which was last amended on June 30, 2011 and
came into effect on September 1, 2011, foreign nationals which have domiciles in the PRC, or have no
domicile in China but have resided in the PRC for one year or more, would be subject to PRC individual
income tax at progressive rate on such income gained within or outside the PRC as wages, salaries,
remuneration for labor service. The Standing Committee of NPC have approved the amendment of the IIT
Law, which took effect on January 1, 2019. Under the amended IIT law, foreign nationals have no domicile
in China but have resided in the PRC for a total of 183 days or more in a tax year, would be subject to PRC
individual income tax on such income gained within or outside the PRC as wages, salaries, remuneration
for labor service. Upon such change of rules, our ability to attract and retain highly skilled foreign scientists
and research technicians to work in China may be materially affected, which may in turn have a material
adverse effect on our business, financial condition, results of operations, cash flows and prospects. Further
adjustments or changes to PRC tax laws or regulations, together with any uncertainty resulting therefrom,
could also have an adverse effect on our business, financial condition and results of operations.

The political relationships between China and other countries may affect our business operations.

During the three years ended December 31, 2020, we generated a substantial portion of our revenue from
companies headquartered in the United States. In addition, many of the pharmaceuticals we work on target
at foreign markets. Our business is therefore subject to constantly changing international economic,
regulatory, social and political conditions, and local conditions in those foreign countries and regions. As
a result, China’s political relationships with those foreign countries and regions may affect the demand for
our services and our ability to serve foreign customers or joint venture customers set up by foreign
companies. There can be no assurance that such customers will not alter their perception of us or their
preferences as a result of adverse changes to the state of political relationships between China and the
relevant foreign countries or regions. Any tensions and political concerns between China and the relevant
foreign countries or regions may cause a decline in the demand for our services and adversely affect our
business, financial condition, results of operations, cash flows and prospects.




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Our business and results of operations may be affected by risks of international policy changes.

We are a pharmaceutical R&D services platform with well-established global operations and a substantial
portion of our customers are pharmaceutical and biotechnology companies outside of China. The demand
for our services by these customers may be impacted by trade policies promulgated by respective local
governments against Chinese pharmaceutical R&D service providers as a result of the rise in trade
protectionism and unilateralism in recent years. In the event the trade tension between China and other
major countries continue to escalate, or any such countries impose restrictions or limitations on
pharmaceutical R&D outsourcing, our business and results of operations may be adversely affected.

Gains on the sales of H Shares and dividends on the H Shares may be subject to PRC income taxes.

Under the applicable PRC tax laws, both the dividends we pay to non-PRC resident individual holders of
H shares (“non-resident individual holders”), and gains realized through the sale or transfer by other means
of H shares by such shareholders, are subject to PRC individual income tax at a rate of 20%, unless reduced
by the applicable tax treaties or arrangements.

Under applicable PRC tax laws, the dividends we pay to, and gains realized through the sale or transfer by
other means of H shares by, non-PRC resident enterprise holders of H shares (“non-resident enterprise
holders”) are both subject to PRC enterprise income tax at a rate of 10%, unless reduced by applicable tax
treaties or arrangements. Pursuant to the Arrangements between the Mainland of China and the Hong Kong
Special Administrative Region for the Avoidance of Double Taxation and the Prevention of Fiscal Evasion
with Respect to Taxes on Incomes (                                                                         )
dated August 21, 2006, any non-resident enterprise registered in Hong Kong that holds directly at least 25%
of the shares of our Company shall pay Enterprise Income Tax for the dividends declared and paid by us
at a tax rate of 5%.

Pursuant to the Circular on Questions Concerning Tax on the Profits Earned by Foreign Invested
Enterprises, Foreign Enterprises and Individual Foreigners from the Transfer of Shares (Equity Interests)
and on Dividend Income (                                                   (     )
               ) issued by the State Administration of Taxation, non-resident individual holders were
temporarily exempted from PRC individual income tax for the dividends or bonuses paid by issuers of
H shares. However, such circular was repealed by the Announcement on the List of Fully or Partially Invalid
and Repealed Tax Regulatory Documents (
            ) dated January 4, 2011.

For non-resident individual holders, gains realized through the transfer of properties are normally subject
to PRC individual income tax at a rate of 20%. However, according to the Circular of the Ministry of
Finance and the State Administration of Taxation on Issues Concerning Individual Income Tax Policies (
                                                          ), income received by individual foreigners from
dividends and bonuses of a foreign-invested enterprise are exempt from individual income tax for the time
being. According to the Circular Declaring that Individual Income Tax Continues to Be Exempted over
Individual Income from Transfer of Shares issued by the MOF and the SAT (
                            ) effective as of March 30, 1998, income from individuals’ transfer of stocks of
listed companies continued to be temporarily exempted from individual income tax. On February 3, 2013,
the State Council approved and promulgated the Notice of Suggestions to Deepen the Reform of System of
Income Distribution (                                                                                 ). On
February 8, 2013, the General Office of the State Council promulgated the Circular Concerning Allocation
of Key Works to Deepen the Reform of System of Income Distribution (
                            ). According to these two documents, the PRC government is planning to cancel
foreign individuals’ tax exemption for dividends obtained from foreign-invested enterprises, and the
Ministry of Finance and the State Administration of Taxation should be responsible for making and
implementing details of such plan. However, relevant implementation rules or regulations have not been
promulgated by the Ministry of Finance and the State Administration of Taxation.

Considering these uncertainties, non-resident holders of our H Shares should be aware that they may be
obligated to pay PRC income tax on the dividends and gains realized through sales or transfers of the
H Shares.


                                                     53
You may experience difficulties in effecting service of legal process, enforcing foreign judgments or
bringing original actions in China against us or our management named in the documents based on
Hong Kong or other foreign laws.

We are incorporated under the laws of the PRC with limited liability, and majority of our assets are located
in the PRC. In addition, a majority of our Directors and Supervisors and all of our senior management
personnel reside within the PRC, and substantially all their assets are located within the PRC. As a result,
it may not be possible to effect service of process within the United States or elsewhere outside the PRC
upon us or most of our Directors, Supervisors and senior management personnel. Furthermore, the PRC
does not have treaties providing for the reciprocal enforcement of judgments of courts with the United
States, the United Kingdom, Japan or many other countries. In addition, Hong Kong has no arrangement for
the reciprocal enforcement of judgments with the United States. As a result, recognition and enforcement
in the PRC or Hong Kong of judgments of a court obtained in the United States and any of the other
jurisdictions mentioned above may be difficult or impossible.

On July 14, 2006, the Supreme People’s Court of the PRC and the government of the Hong Kong Special
Administrative Region entered into the Arrangement on Reciprocal Recognition and Enforcement of
Judgments in Civil and Commercial Matters by Courts of the Mainland and the Hong Kong Special
Administration Region Pursuant to Choice of Court Agreements between Parties Concerned (
                                                                                   ) (the “2006 Arrangement”).
Under the 2006 Arrangement, where any designated PRC court or any designated Hong Kong court has
made an enforceable final judgment requiring payment of money in a civil or commercial case pursuant to
a choice of court agreement in writing, any party concerned may apply to the relevant PRC court or Hong
Kong court for recognition and enforcement of the judgment. It is not possible to enforce a judgment
rendered by a Hong Kong court in the PRC if the parties in dispute have not agreed to enter into a choice
of court agreement in writing. In addition, the 2006 Arrangement has expressly provided for “enforceable
final judgement,” “specific legal relationship” and “written form.” A final judgement that does not comply
with the 2006 Arrangement may not be recognized and enforced in a PRC court.

On January 18, 2019, the Supreme People’s Court of the PRC and the government of the Hong Kong Special
Administrative Region entered into the Arrangement on Reciprocal Recognition and Enforcement of
Judgments in Civil and Commercial Matters by the Courts of the Mainland and of the Hong Kong Special
Administrative Region (                                                                            ) (the
“2019 Arrangement”). Under the 2019 Arrangement, any party concerned may apply to the relevant PRC
court or Hong Kong court for recognition and enforcement of the effective judgments in civil and
commercial cases subject to the conditions set forth in the 2019 Arrangement. Although the 2019
Arrangement has been signed, the outcome and effectiveness of any action brought under the 2019
Arrangement may still be uncertain. We cannot assure you that an effective judgment that complies with the
2019 Arrangement can be recognized and enforced in a PRC court.

RISKS RELATING TO THE BONDS, THE SHARES AND THE OFFERING

The Bonds will be effectively subordinated to all of the Issuer’s secured debt.

The Bonds are general senior unsecured obligations. The Bonds will be effectively subordinated to all the
Issuer’s secured indebtedness to the extent of the value of the assets securing such indebtedness. In addition,
the Bonds will, subject to some limitations, permit the Issuer to incur additional secured indebtedness in
connection with bank and other financing arrangements.

In the event of bankruptcy, liquidation, reorganization or other winding-up, the Issuer’s assets that secure
the Issuer’s secured indebtedness will be available to pay obligations on the Bonds only after all secured
indebtedness, together with accrued interest, has been repaid. If the Issuer is unable to repay its secured
indebtedness, the lenders could foreclose on substantially all the Issuer’s assets which serve as collateral.
Under such circumstances, the Issuer’s secured lenders would be entitled to be repaid in full from the
proceeds of the liquidation of those assets before those assets would be available for distribution to other
creditors, including holders of the Bonds. Holders of the Bonds will participate in the proceeds of the


                                                      54
liquidation of the Issuer’s remaining assets ratably with holders of the Issuer’s unsecured indebtedness that
is deemed to be of the same class as the Bonds, and potentially with all of the Issuer’s other general
creditors.

Claims by holders of the Bonds are structurally subordinated to creditors of the Issuer’s subsidiaries.

The Issuer’s ability to make payments in respect of the Bonds depends largely upon the receipt of dividends,
distributions, interest of advances from its subsidiaries. The ability of the Issuer’s subsidiaries to pay
dividends and other amounts to the Issuer may be subject to such subsidiaries’ profitability and applicable
laws. Payments under the Bonds are structurally subordinated to all existing and future liabilities and
obligations of each of the Issuer’s subsidiaries. Claims of creditors of such companies will have priority as
to the assets of such companies over the Issuer and its creditors, including holders of the Bonds.

There may not be a liquid market for the Bonds, and Bondholders may not be able to sell their Bonds
at an attractive price or at all.

The Bonds are a new issue of securities for which there is currently no trading market. Although, application
has been made to the Hong Kong Stock Exchange for the listing of, and permission to deal in, the Bonds,
the Issuer cannot assure investors as to the liquidity of the Bonds, that an active trading market will develop,
or that the Issuer will be able to maintain a listing of the Bonds on the Hong Kong Stock Exchange. If such
a market were to develop, the Bonds could trade at prices that may be higher or lower than the initial price
depending on many factors, including, but not limited to, the prevailing interest rates, the Issuer’s operating
and financial results and the market for similar securities. None of the Joint Lead Managers is obligated to
make a market in the Bonds and any such market making, if commenced, may be discontinued at any time
at the sole discretion of the Joint Lead Managers. Accordingly, there is no assurance that a liquid trading
market for the Bonds will develop or be sustained. If an active trading market for the Bonds does not
develop or is not sustained, the market price and liquidity of the Bonds may be adversely affected.

Even if an active trading market were to develop, the Bonds could trade at prices that might be lower than
the initial offering price. Future trading prices of the Bonds will depend on many factors, including, but not
limited to:

     prevailing interest rates and interest rate volatility;

     the market for similar securities;

     the Issuer’s operating and financial results;

     the publication of earnings estimates or other research reports and speculation in the press or the
     investment community;

     the market price of the Bonds; or

     changes in the Group’s industry and competition; and general market and economic conditions.

Accordingly, Bondholders may not be able to sell their Bonds at an attractive price or at all, and may incur
losses on their investments.

The Trustee may request the Bondholders to provide an indemnity and/or security and/or prefunding to
its satisfaction.

In certain circumstances including giving of notice to the Group pursuant to Condition 14, the Trustee may
request Bondholders to provide an indemnity and/or security and/or prefunding to its satisfaction before it
takes steps and/or actions and/or institutes proceedings on behalf of Bondholders. The Trustee shall not be
obliged to take any such steps and/or actions and/or institute any such proceedings if it is not indemnified


                                                      55
and/or secured and/or prefunded to its satisfaction. Negotiating and agreeing to an indemnity and/or
security and/or prefunding can be a lengthy process and may affect when such steps and/or actions can be
taken and/or such proceedings can be instituted. The Trustee may not be able to take steps and/or actions
and/or institute proceedings, notwithstanding the provision of an indemnity and/or security and/or
prefunding to it, in breach of the terms of the Trust Deed and in circumstances where there is uncertainty
or dispute as to the applicable laws or regulations and, to the extent permitted by the agreements and the
applicable law, it will be for the Bondholders to take such steps and/or actions and/or institute such
proceedings directly.

Bondholders will have no rights as holders of the Shares prior to conversion of the Bonds, but are subject
to changes made with respect to the Shares.

Unless and until the Bondholders acquire the Shares upon conversion of the Bonds, Bondholders will have
no rights with respect to the Shares, including any voting rights or rights to receive any regular dividends
or other distributions with respect to the Shares. Upon conversion of the Bonds, these holders will be
entitled to exercise the rights of holders of the Shares only as to actions for which the applicable record date
occurs after the date of conversion. However, such Bondholders are subject to all changes affecting the
Shares. For example, in the event that an amendment is proposed to the Issuer’s articles requiring
shareholder approval, and the record date for determining the shareholders of record entitled to vote on the
amendment occurs prior to the date of conversion of the Bonds for such Shares and (as applicable) the date
of registration by the relevant Bondholder as the holder thereof, that Bondholder would not be entitled to
vote on the amendment but would nevertheless be subject to any resulting changes in the powers,
preferences or special rights that affect the Shares after conversion.

There is a limited period during which the Bondholders may convert their Bonds.

Subject as provided in the Terms and Conditions, Conversion Rights under the Terms and Conditions may
only be exercised in certain limited circumstances (subject to any applicable fiscal or other laws or
regulations and as further provided in the Terms and Conditions) from and including the 41st day after the
Issue Date until the earlier of (a) the close of business on the date falling 10 working days prior to the
Maturity Date; or (b) if the Bonds shall have been called for redemption by the Issuer before the Maturity
Date, up to and including the close of business on a date no later than 10 working days prior to the date
fixed for redemption. If the Conversion Rights are not exercised by Bondholders during the Conversion
Period, the Bonds will be redeemed at 106.43 per cent. of its outstanding principal amount on the Maturity
Date unless the Bonds are previously redeemed, converted or purchased and canceled in accordance with
the Terms and Conditions.

Securities law restrictions on the resale and conversion of the Bonds and the resale of the Shares issuable
upon their conversion may limit Bondholders’ ability to sell the Bonds in the United States.

The Bonds and the Shares into which the Bonds are convertible have not been and will not be registered
under the Securities Act, any state securities laws or the securities laws of any other jurisdiction. Unless
and until they are registered, the Bonds and the Shares issuable upon conversion may not be offered, sold
or resold except pursuant to an exemption from registration under the Securities Act and applicable state
laws or in a transaction not subject to such laws. The Bonds are being offered and sold outside the U.S. in
reliance on Regulation S under the Securities Act. The Issuer is not required to register the Bonds and the
Shares into which the Bonds are convertible under the terms of the Bonds. Hence, future resales of the
Bonds and the Shares into which the Bonds are convertible may only be made pursuant to an exemption
from registration under the Securities Act and applicable state laws or in a transaction not subject to such
laws.




                                                      56
The Issuer will follow the applicable corporate disclosure standards for debt securities listed on the Hong
Kong Stock Exchange, which may be different from those applicable to companies in certain other
countries.

The Issuer will be subject to reporting obligations in respect of the Bonds to be listed on the Hong Kong
Stock Exchange. The disclosure standards imposed by the Hong Kong Stock Exchange may be different
from those imposed by securities exchanges in other countries or regions. As a result, the level of
information that is available may not correspond to what investors in the Bonds are accustomed to or may
expect.

The Bondholders may be subject to tax on their income or gain from the Bonds.

Prospective investors of the Bonds are advised to consult their own tax advisers concerning the overall tax
consequences of the acquisition, ownership or disposition (including upon conversion of the Bonds) of the
Bonds or the Shares. (See “Taxation” for certain PRC, Hong Kong and European Union tax consequences.)

Gains on the transfer of the Bonds may be subject to income tax and value-added tax under PRC tax laws.

Under the Enterprise Income Tax Law of the PRC (the “EIT Law”) which took effect on 1 January 2008
and its implementation rules, any gains realised on the transfer of the Bonds by holders who are deemed
under the EIT Law as non-resident enterprises may be subject to PRC enterprise income tax if such gains
are regarded as income derived from sources within the PRC. Under the EIT Law, a “nonresident enterprise”
means an enterprise established under the laws of a jurisdiction other than the PRC and whose actual
administrative organisation is not in the PRC, which has established offices or premises in the PRC, or
which has not established any offices or premises in the PRC but has obtained income derived from sources
within the PRC. There remains uncertainty as to whether the gains realised on the transfer of the Bonds by
non-resident enterprise Bondholders would be treated as income derived from sources within the PRC and
be subject to PRC enterprise income tax. In addition, under the Individual Income Tax Law of the PRC
(the “IIT Law”) as last amended on 31 August 2018, and its implementation rules, any individual who has
no domicile and does not live within the territory of the PRC or who has no domicile but has lived within
the territory of China for less than 183 days shall pay individual income tax for any income obtained within
the PRC. There is uncertainty as to whether gains realised on the transfer of the Bonds by individual holders
who are not PRC citizens or residents will be subject to PRC individual income tax. If such gains are subject
to PRC income tax, the 10% enterprise income tax rate and 20% individual income tax rate will apply
respectively unless there is an applicable tax treaty or arrangement that reduces or exempts such income tax.
The taxable income will be the balance of the total income obtained from the transfer of the Bonds minus
all costs and expenses that are permitted under PRC tax laws to be deducted from the income. According
to the Arrangement between the Mainland of China and the Hong Kong Special Administrative Region for
the Avoidance of Double Taxation and the Prevention of Fiscal Evasion with Respect to Taxes on Income
(                                                                           ) (the “Arrangement”) which was
promulgated on 21 August 2006, Bondholders who are Hong Kong residents, including both enterprise
holders and individual holders, will be exempted from PRC income tax on capital gains derived from a sale
or exchange of the Bonds if such capital gains are not connected with an office or establishment that the
Bondholders have in the PRC and all the other relevant conditions are satisfied. On 23 March 2016, the
MOF and the State Administration of Taxation issued the Circular of Full Implementation of Replacing
Business Tax with Value-Added Tax Reform (                                                  ) (Caishui [2016]
No. 36) (“Circular 36”), which introduced a new value-added tax (“VAT”) from 1 May 2016. Under Circular
36, VAT is applicable where the entities or individuals provide financial services such as providing loans
within the PRC. The Issuer will be obliged to withhold VAT of 6% and certain surcharges on payments of
interest and certain other amounts on the Bonds paid by the Issuer to Bondholders that are non-resident
enterprises or individuals. VAT is unlikely to be applicable to any transfer of Bonds between entities or
individuals located outside the PRC and therefore unlikely to be applicable to gains realised upon such
transfers of Bonds, but there is uncertainty as to the applicability of VAT if either the seller or buyer of
Bonds is located inside the PRC. Circular 36 together with other laws and regulations pertaining to VAT are
relatively new, and the interpretation and enforcement of such laws and regulations involve uncertainties.

If a Bondholder, being a non-resident enterprise or non-resident individual, is required to pay any income
tax or VAT on gains on the transfer of the Bonds, the value of the relevant Bondholder’s investment in the
Bonds may be materially and adversely affected.


                                                     57
The interests on the Bonds is subject to income tax under PRC tax laws.

As the Company is a PRC resident enterprise, interests paid to non-resident enterprises holders of Bonds
is treated as income derived from sources within China and is subject to the PRC withholding tax at a rate
of 10%. In the case of non-resident individual holders of the Shares, the tax may be withheld at a rate of
20%. To the extent that China has entered into arrangements relating to the avoidance of double-taxation
with any jurisdiction, such as Hong Kong, that allow a lower rate of tax, such lower rate may apply to
qualified Bondholders.

The EIT Law and its implementation regulations, impose a tax at the rate of 10% on capital gains realised
by holders of the Shares that are “non-resident enterprises” so long as any such “non-resident enterprise”
holder does not have an establishment or place of business in China or, despite the existence of
establishment or place of business in China, the relevant gain is not effectively connected with such
establishment or place of business in China, to the extent such capital gains are sourced within China.
Pursuant to these provisions of the PRC tax law, despite many uncertainties with respect to their application,
as the Company is considered a PRC resident enterprise, the capital gains realised by holders of the Shares
may be treated as income derived from sources within China and be subject to the PRC tax at a rate of 10%
(or possibly 20% in the case of non-resident individual holders of the Shares). To the extent that the PRC
has entered into arrangements relating to the avoidance of double taxation with any jurisdiction, such as
Hong Kong, that allow a lower rate of tax, such lower rate may apply to qualified investors in the Shares.

If the Issuer or any of its subsidiaries is unable to comply with the restrictions and covenants in its debt
agreements, there could be a default under the terms of these agreements, which could cause repayment
of its debt to be accelerated.

If the Issuer or any of its subsidiaries is unable to comply with the restrictions and covenants or its current
or future debt obligations and other agreements, there could be a default under the terms of these
agreements. In the event of a default under these agreements, the holders of the debt could terminate their
commitments to lend, accelerate repayment of the debt and declare all outstanding amounts due and payable
or terminate the agreements, as the case may be. As a result, a default under one debt agreement may cause
the acceleration of repayment of not only such debt but also other debt, including the Bonds, or result in
a default under the Issuer’s or such subsidiary’s other debt agreements. If any of these events occurs, there
is no assurance that the Issuer will have sufficient assets and cash flow to repay in full all of its
indebtedness, or that the Issuer would be able to find alternative financing. Even if the Issuer could obtain
alternative financing, it cannot guarantee that it would be on terms that are favorable or acceptable to the
Issuer.

The Issuer may not have the ability to redeem the Bonds.

Bondholders may require the Issuer, subject to certain conditions, to redeem for cash some or all of their
Bonds upon a transaction or event constituting a Relevant Event as described under “Terms and Conditions
of the Series 1 Bonds – Redemption, Purchase and Cancellation – Redemption at the Option of the
Bondholders”, “Terms and Conditions of the Series 2 Bonds – Redemption, Purchase and Cancellation –
Redemption at the Option of the Bondholders”, “Terms and Conditions of the Series 1 Bonds – Redemption,
Purchase and Cancellation – Redemption for Relevant Events” and “Terms and Conditions of the Series 2
Bonds – Redemption, Purchase and Cancellation – Redemption for Relevant Events”. The Issuer may not
have sufficient funds or other financial resources to make the required redemption in cash at such time or
the ability to arrange necessary financing on acceptable terms, or at all. The Issuer’s ability to redeem the
Bonds in such event may also be limited by the terms of other debt instruments. Failure to repay, repurchase
or redeem tendered Bonds by the Issuer would constitute an event of default under the Bonds, which may
also constitute a default under the terms of other indebtedness held by the Issuer.

The Bonds may be redeemed at the option of the Issuer, which may adversely affect the trading price and
liquidity of the Bonds and may subject Bondholders to reinvestment risks.

Subject to certain conditions, the Bonds may be redeemed at the Issuer’s option, in respect of the Series 1
Bonds only, at any time after June 18, 2024, but prior to the Maturity Date or, in respect of both Series, at
any time if, the aggregate principal amount of the Bonds outstanding is less than 10 per cent. of the


                                                      58
aggregate principal amount originally issued at, in respect of the Series 1 Bonds, the principal amount, and
in respect of the Series 2 Bonds, the U.S. Dollar Equivalent of the Early Redemption Amount as of the
relevant redemption date. See “Terms and Conditions of the Series 1 Bonds – Redemption, Purchase and
Cancellation – Redemption at the Option of the Issuer” “Terms and Conditions of the Series 2 Bonds –
Redemption, Purchase and Cancellation – Redemption at the Option of the Issuer”. As a result, the trading
price of the Bonds may be affected when this option of the Issuer becomes exercisable. Accordingly,
Bondholders may not be able to sell their Bonds at an attractive price, thereby exercise of the Issuer’s option
to redeem the Bond could have a material adverse effect on the trading price and liquidity of the Bonds.
In addition, the Bondholders may not be able to reinvest the redemption proceeds at an effective interest
rate and may only be able to do so at a significantly lower rate. Potential investors should consider
reinvestment risk in light of other investments available at that time.

Short selling of the Shares by Bondholders could materially and adversely affect the market price of the
Shares.

The issuance of the Bonds may result in downward pressure on the market price of the Shares. Investors
in convertible securities may seek to hedge their exposure in the underlying equity securities, often through
short selling of the underlying equity securities or similar transactions. Any short selling and similar
hedging activity could place significant downward pressure on the market price of the Shares, thereby
having a material adverse effect on the market value of the Shares owned by an investor as well as on the
trading price of the Bonds.

The Issuer may be unable to obtain and remit foreign currencies out of China.

The Issuer’s ability to satisfy its obligations under the Bonds will be affected by its ability to obtain and
remit sufficient foreign currency. The Issuer must present certain documents to the SAFE, its authorized
branch, or the designated foreign exchange bank, for registration before it can obtain and remit foreign
currencies out of China. If the Issuer for any reason fails to satisfy any of the PRC legal requirements for
remitting foreign currency payments, it may affect the Issuer’s ability to satisfy its obligations under the
Bonds without any delay.

The market value of the Bonds may fluctuate.

Trading prices of the Bonds are influenced by numerous factors, including the results of operations and/or
financial condition and business strategy (in particular further issuance of debt or corporate events such as
share sales, reorganizations, takeovers or share buybacks) of the Group and/or the subsidiaries and/or
associated companies of the Group, political, economic, financial, regulatory and any other factors that can
affect the capital markets, the industry, the Group and/or the subsidiaries and/or associated companies of
the Group generally. Adverse economic developments, in Hong Kong and China as well as countries in
which the Group and/or the subsidiaries and/or associated companies of Group operate or have business
dealings, could have a material adverse effect on the Hong Kong economy and the results of operations
and/or the financial condition of the Group and/or the subsidiaries and/or associated companies of the
Group.

In addition, the market price of the Bonds is expected to be affected by fluctuations in the market price of
the Shares. There can be no certainty as to the effect, if any, that future issues or sales of Shares, or the
availability of such Shares for future issue or sale, will have on the market price of the Shares prevailing
from time to time and therefore on the market price of the Bonds. Disposals of shares by shareholders or
a perception in the market that such disposals could occur, could adversely affect the prevailing market
price of the Shares and the Bonds.

Changes in interest rates may have an adverse effect on the price of the Bonds.

The Bondholders may suffer unforeseen losses due to fluctuations in interest rates. Generally, a rise in
interest rates may cause a fall in the prices of the Bonds, resulting in a capital loss for the Bondholders.
However, the Bondholders may reinvest the interest payments at higher prevailing interest rates.
Conversely, when interest rates fall, the prices of the Bonds may rise. The Bondholders may enjoy a capital
gain but interest payments received may be reinvested at lower prevailing interest rates.


                                                      59
The return on the Bonds may decrease due to inflation.

The Bondholders may suffer erosion on the return of their investments due to inflation. The Bondholders
would have an anticipated rate of return based on expected inflation rates on the purchase of the Bonds. An
unexpected increase in inflation could reduce the actual returns.

The U.S. dollar return on the Series 2 Bonds may be adversely affected by changes in the exchange rates
between the Renminbi and the U.S. dollar.

The Series 2 Bonds are U.S. dollar-settled debt instruments. Bondholders are required to pay the
subscription money for the Bonds in U.S. dollars based on the exchange rate between Renminbi and the U.S.
dollar fixed on the pricing date of the Bonds. In addition, all amounts due from the Issuer under the Bonds,
including the redemption price, premium and/or default interest of the Bonds, will be settled in U.S. dollars
at the spot rate between Renminbi and the U.S. dollar prior to the time of payment. Accordingly, the U.S.
dollar return on the Bonds, or yield to maturity, will depend on the principal amount, the premium and/or
default interest converted into U.S. dollars at the spot rate. Any volatility of the exchange rate between
Renminbi and the U.S. dollar during the term of the Bonds will affect the return on the Bonds, or yield to
maturity, in U.S. dollars. In particular, any devaluation of the Renminbi against the U.S. dollar during the
term of the Bonds will decrease the U.S. dollar return on the Bonds and will result in the yield to maturity
of the Bonds in U.S. dollars being less than the stated yield to maturity of the Bonds, which is calculated
in Renminbi. In the event of a material devaluation of the Renminbi against the U.S. dollar, Bondholders
may not receive the full U.S.dollar subscription money upon redemption of the Bonds.

An active trading market for the Bonds may not develop.

The Bonds are a new issue of securities for which there is currently no trading market. Application has been
made to the Hong Kong Stock Exchange for the listing, and permission to deal in, the Bonds by way of debt
issues to Professional Investors only. However, no assurance can be given that an active trading market for
the Bonds will develop or as to the liquidity or sustainability of any such market, the ability of Bondholders
to sell their Bonds or the price at which Bondholders will be able to sell their Bonds. If an active market
for the Bonds fails to develop or be sustained, the trading price of the Bonds could fall.

If an active trading market were to develop, the Bonds could trade at prices that may be lower than their
initial offering price. Whether or not the Bonds will trade at lower prices depends on many factors,
including:

     prevailing interest rates and the markets for similar securities;

     the price of the Shares;

     general economic conditions and the conditions of the real estate industry; and

     the Group’s financial condition and historical financial performance and future prospects.

The Bonds may not be a suitable investment for all investors.

Each potential investor in the Bonds must determine the suitability of that investment in light of its own
circumstances. In particular, each potential investor should:

     have sufficient knowledge and experience to make a meaningful evaluation of the Bonds, the merits
     and risks of investing in the Bonds and the information contained in this Offering Circular or any
     applicable supplement;

     have access to, and knowledge of, appropriate analytical tools to evaluate, in the context of its
     particular financial situation, an investment in the Bonds and the impact such investment will have on
     its overall investment portfolio;

     have sufficient financial resources and liquidity to bear all of the risks of an investment in the Bonds,
     including where the currency for principal or interest payments is different from the potential
     investor’s currency;


                                                     60
     understand thoroughly the terms of the Bonds and be familiar with the behavior of any relevant indices
     and financial markets; and

     be able to evaluate (either alone or with the help of a financial adviser) possible scenarios for
     economic, interest rate and other factors that may affect its investment and its ability to bear the
     applicable risks.

The Bonds are complex financial instruments. Sophisticated institutional investors generally do not
purchase complex financial instruments as stand-alone investments. They purchase complex financial
instruments as a way to reduce risk or enhance yield with an understood, measured, appropriate addition
of risk to their overall portfolios. A potential investor should not invest in the Bonds which are complex
financial instruments unless it has the expertise (either alone or with the help of a financial adviser) to
evaluate how the Bonds will perform under changing conditions, the resulting effects on the value of the
Bonds and the impact this investment will have on the potential investor’s overall investment portfolio.

Modification and waivers may be made in respect of the Terms and Conditions and the Trust Deed by the
Trustee without the consent of the holders of the Bonds.

The Terms and Conditions contain provisions for calling meetings of Bondholders to consider matters
affecting their interests generally. These provisions permit defined majorities to bind all Bondholders
including Bondholders who did not attend and vote at the relevant meeting and Bondholders who voted in
a manner contrary to the majority.

The Trust Deed further provides that the Trustee may, but shall not be obliged to, agree without the consent
of the Bondholders to any modification of the Trust Deed, the Terms and Conditions, the Bonds and/or the
Agency Agreement which in the opinion of the Trustee is of a formal, minor or technical nature or is made
to correct a manifest error or to comply with any mandatory provision of law.

In addition, the Trustee may also, without the consent of the Bondholders, agree to any modification (except
as mentioned in the Trust Deed) and any waiver or authorization of any breach or proposed breach of the
Bonds, the Trust Deed, the Terms and Conditions or the Agency Agreement (other than a proposed breach,
or a breach relating to the subject of certain reserved matters) if, in the opinion of the Trustee, the interests
of the Bondholders will not be materially prejudiced thereby.

Exchange rate risks and exchange controls may affect an investor’s returns on the Bonds.

Investment in the Bonds presents certain risks relating to currency conversions if an investor’s financial
activities are denominated principally in a currency or currency unit (the “Investor’s Currency”) other than
U.S. dollars. These include the risk that exchange rates may significantly change (including changes due
to devaluation of the U.S. dollars or revaluation of the Investor’s Currency) and the risk that authorities with
jurisdiction over the Investor’s Currency may impose or modify exchange controls. An appreciation in the
value of the Investor’s Currency relative to U.S. dollars would decrease (i) the Investor’s
Currency-equivalent yield on the Bonds; (ii) the Investor’s Currency-equivalent value of the principal
payable on the Bonds; and (iii) the Investor’s Currency-equivalent market value of the Bonds. Government
and monetary authorities may impose (as some have done in the past) exchange controls that could
adversely affect an applicable exchange rate. As a result, investors may receive less principal than expected,
or no principal.

Legal investment considerations may restrict certain investments.

The investment activities of certain investors are subject to legal investment laws and regulations, or review
or regulation by certain authorities. Each potential investor should consult its legal advisers to determine
whether and to what extent:

     the Bonds are legal investments for it;

     the Bonds can be used as collateral for various types of borrowing; and


                                                       61
     any other restrictions apply to its purchase or pledge of the Bonds.

Financial institutions should consult their legal advisers or the appropriate regulators to determine the
appropriate treatment of the Bonds under any applicable risk-based capital or similar rules.

The Company’s subsidiaries, jointly controlled entities and associated companies are subject to
restrictions on the payment of dividends and the repayment of intercompany loans or advances to the
Company, its jointly controlled entities and associated companies.

The Company depends on the receipt of dividends and the interest and principal payments on intercompany
loans or advances from its subsidiaries, jointly controlled entities and associated companies to satisfy its
obligations, including its obligations under the Bonds. The ability of the Company’s subsidiaries, jointly
controlled entities and associated companies to pay dividends and make payments on intercompany loans
or advances to their shareholders is subject to, among other things, distributable earnings, cash flow
conditions, restrictions contained in the articles of association of these companies, applicable laws and
restrictions contained in the financing agreements or other debt instruments of such companies. The
Company cannot assure that its subsidiaries, jointly controlled entities and associated companies will have
distributable earnings or will be permitted to distribute their distributable earnings to it as it anticipates, or
at all. In addition, dividends payable to it by these companies are limited by the percentage of its equity
ownership in these companies. Further, if any of these companies raises capital by issuing equity securities
to third parties, dividends declared and paid with respect to such shares would not be available to the
Company to make payments on the Bonds. These factors could reduce the payments that the Company
receives from its subsidiaries, jointly controlled entities and associated companies, which would restrict its
ability to meet its payment obligations under the Bonds.

PRC laws and regulations permit payment of dividends only out of accumulated profits as determined in
accordance with PRC accounting standards and regulations. The PRC subsidiaries, jointly controlled
entities and associated companies of the Company or its non-PRC subsidiaries, jointly controlled entities
and associated companies are also required to (i) set aside a portion of their post-tax profits according to
PRC accounting standards and regulations to fund certain reserves that are not distributable as cash
dividends and (ii) cover the deficit of prior years to the extent such reserves fall short of deficit coving.

Any failure to complete the relevant filings under the NDRC Circular and the relevant registration with
SAFE within the prescribed time frame following the completion of the issue of the Bonds may have
adverse consequences for the Issuer and/or the investors of the Bonds.

NDRC issued Circular on Promoting the Reform of the Administrative System on the Issuance by
Enterprises of Foreign Debt Filings and Registrations (
                  (         [2015]2044 ) (the “NDRC Circular”) on September 14, 2015, which came into
effect on the same day. According to the NDRC Circular, domestic enterprises and their overseas controlled
entities shall procure the registration of any debt securities issued outside the PRC with NDRC prior to the
issue of the securities and notify the particulars of the relevant issues within 10 working days after the
completion of the issue of the securities. The NDRC Circular is silent on the legal consequences of
non-compliance with the pre-issue registration requirement. The Issuer has obtained the NDRC pre-
issuance registration on January 12, 2021. Similarly, the legal consequences of non-compliance with the
post-issue notification requirement under the NDRC Circular is unclear. Potential investors of the Bonds are
advised to exercise due caution when making their investment decisions. The Issuer has undertaken to
notify NDRC of the particulars of the issue of the Bonds within 10 Registration Business Days after the
Issue Date.

In accordance with the Foreign Debt Registration Measures issued by SAFE on April 28, 2013, which came
into effect on May 13, 2013 and as amended from time to time (the “Foreign Debt Registration
Measures”) and the Circular of the People’s Bank of China on Issues Concerning the Overall Macro
Prudential Management System for Cross-border Financing (
                    ) (the “Cross-Border Financing Circular”), the Issuer shall complete foreign debt
registration in respect of the issue of the Bonds with the local branches of SAFE in accordance with relevant


                                                       62
laws and regulations. According to the Foreign Debt Registration Measures and the Cross-Border Financing
Circular and based on the Issuer’s inquiries with local SAFE, the Issuer is required to register the Bonds
within 15 working days after execution of the Issue Date and complete such registration in accordance
relevant laws and regulations. Before such registration of the Bonds is completed, it is uncertain whether
the Bonds are enforceable under the PRC laws and it may be difficult for Bondholders to recover amounts
due from the Issuer, and the Issuer may not be able to remit the proceeds of the offering into the PRC or
remit money out of the PRC in order to meet its payment obligations under the Bonds. Pursuant to article
27(5) of the Foreign Debt Registration Measures, a failure to comply with registration requirements may
result in a warning and fine as set forth under article 48 of the Foreign Exchange Administrative Regulations
(               ) promulgated by the State Council in 2008. However, pursuant to article 40 of the Foreign
Debt Administration Provisional Rules (                          ) promulgated by MOF, NDRC and SAFE, a
failure by a domestic entity to register a foreign debt contract will render the contract not legally binding
and unenforceable. Under the Terms and Conditions, the Issuer has undertaken to use its best endeavors,
and it intends, to complete the registration of the Bonds with SAFE within 90 Registration Business Days
of the Issue Date. The Issuer has already consulted with local SAFE in connection with the registration
procedures and documentary requirements. In the unlikely event that having exercised its best endeavors,
the Issuer is unable to complete such registration on or before the Registration Deadline (as defined in the
Terms and Conditions), the Issuer may have difficulty in remitting funds offshore to service payments in
respect of the Bonds and investors may encounter difficulties in enforcing judgments obtained in the Hong
Kong courts with respect to the Bonds and the Trust Deed in the PRC. In such circumstances, the value and
secondary market price of the Bonds may also be materially and adversely affected.

We are subject to risks related to PBOC’s changes in registration and reporting requirements.

On January 11, 2017, the PBOC issued the Circular of the People’s Bank of China on the Macro-prudence
Management of Cross-border Financing in Full Aperture (the “Cross Border Financing Circular”, or the
(                                                            ), which came into effect on January 11, 2017.
The Cross Border Financing Circular established a mechanism aimed at regulating cross border financing
activities conducted by domestic institutions, including domestic enterprises and financial institutions other
than the governmental financing platforms and real estate enterprises, based on the capital or net asset of
the borrowing entities using a prudent management principle on a macro nationwide scale.

Neither the PBOC nor the SAFE has promulgated implementation rules of the Cross Border Financing
Circular. The registration and reporting process for the aforesaid regulations and the interpretation and
enforcement of the Cross Border Financing Circular thus involve substantial uncertainties due to its recent
promulgation and publication.

Bondholders have limited anti-dilution protection.

The Conversion Price will be adjusted in the event that there is a consolidation, sub-division or
reclassification, capitalization of profit or reserves, rights issue, capital distributions, other dilutive events
or upon change of control but only in the situations and only to the extent provided in “Terms and
Conditions of the Series 1 Bonds – Conversion – Adjustments to Conversion Price” and “Terms and
Conditions of the Series 2 Bonds – Conversion – Adjustments to Conversion Price”. There is no requirement
that there should be an adjustment for every corporate or other event that may affect the value of the Shares.
Events in respect of which no adjustment is made may adversely affect the market price of the Shares and
therefore, adversely affect the market price of the Bonds.

Future issuances of Shares or equity-related securities may depress the trading price of the Shares.

Any issuance of the Issuer’s equity securities after this offering could dilute the interest of the existing
shareholders and could substantially decrease the trading price of the Shares. The Issuer may issue equity
securities in the future for a number of reasons, including to finance its operations and business strategy
(including in connection with acquisitions, strategic collaborations or other transactions), to adjust its ratio
of debt-to-equity, to satisfy its obligations upon the exercise of outstanding warrants, options or other
convertible bonds or for other reasons. Sales of a substantial number of Shares or other equity-related


                                                       63
securities in the public market (or the perception that such sales may occur) could depress the market price
of the Shares. The Issuer cannot predict the effect that future sales of the Shares or other equity-related
securities would have on the market price of the Shares. In addition, the price of the Shares could be
affected by possible sales of the Shares by investors who view the Bonds as a more attractive means of
obtaining equity participation in the Issuer and by hedging or engaging in arbitrage trading activity
involving the Bonds.

The conversion of some or all of the Bonds will dilute the ownership interest of existing shareholders.

The conversion of some or all of the Bonds will dilute the ownership interest of existing shareholders. Any
sales in the public market of the Shares issuable upon such conversion or exercise, or the perception that
such sale may occur could adversely affect prevailing market prices of the Shares and the Bonds. In
addition, the existence of the Bonds may encourage short selling by market participants because the
conversion of the Bonds could depress the market price of the Shares.

Enforcement of shareholder rights; mandatory arbitration.

Currently, the primary sources of shareholder rights are our Articles of Association, the PRC Company Law,
the PRC regulations and the listing rules of the Hong Kong Stock Exchange and the Shanghai Stock
Exchange, which, among other things, impose certain standards of conduct, fairness and disclosure on us,
our directors and our controlling shareholder. In general, these rights are not as broad as those applicable
to companies incorporated in the United States, the United Kingdom and many European countries. In
addition, the mechanism for enforcement of rights under the corporate framework to which we are subject
may also be relatively undeveloped and untested. To our knowledge, there has not been any published report
of judicial enforcement in the PRC by holders of H Shares of their rights under constituent documents of
joint stock limited companies or the PRC Company Law or in the application or interpretation of the PRC
or Hong Kong regulatory provisions applicable to PRC joint stock limited companies. We cannot assure you
that our shareholders will enjoy the protections to which they may be entitled in other jurisdictions.

China does not have treaties providing for the reciprocal recognition and enforcement of judgments of
courts with the United States, the United Kingdom or most European countries, and therefore recognition
and enforcement in China of judgments of a court in any of these jurisdictions in relation to any matter not
subject to a binding arbitration provision may not be assured. Our Articles of Association as well as the
Listing Rules provide that most disputes between holders of H Shares and us, our directors, supervisors,
officers or holders of domestic shares, arising out of the Articles of Association or the PRC Company Law
concerning the affairs of our company or with respect to the transfer of our shares, are to be resolved
through arbitration by arbitration organizations in Hong Kong or China, rather than through a court of law.
On June 21, 1999, an arrangement was made between Hong Kong and Mainland China for the mutual
enforcement of arbitral awards. This arrangement was approved by the Supreme People’s Court of the PRC
and the Hong Kong Legislative Council, and became effective on February 1, 2000 and was further
supplemented in 2020 and 2021. We are uncertain as to the outcome of any action brought in China to
enforce an arbitral award granted to shareholders.

Bondholders may only be entitled to the Cash Settlement Amount.

During the relevant Conversion Period (as defined in the section headed “The Offering”), the Issuer has the
option to satisfy the Conversion Right (as defined in the section headed “The Offering”) in respect of a
relevant conversion notice by electing to pay to the Bondholder an amount of cash in U.S. dollars equivalent
to the relevant cash settlement amount (the “Cash Settlement Amount”) in order to satisfy such
Conversion Right in whole or in part in lieu of delivery of Shares. In such event a Bondholder will receive
fewer or no Shares (as applicable) on conversion of its Bonds.

The Cash Settlement Amount payable to Bondholders will be subject to market price volatility during the
20 H Share Stock Exchange Business Day calculation period.

Upon exercise of a Conversion Right, the conversion of the relevant Bonds will be physically settled unless
the Issuer elects to cash settle by either (a) providing a Cash Settlement Notice to the relevant Bondholder


                                                     64
during the initial Conversion Period or (b) electing to cash settle in the final Conversion Period
determination. The Cash Settlement Amount will be calculated using the average of the volume weighted
average price of the H Shares for each day during the 20 days on which the Stock Exchange is open for
business of dealing in securities (“20 H Share Stock Exchange Business Days”). During the initial
Conversion Period, the Cash Settlement Amount will be calculated after the date of the relevant Cash
Settlement Notice. As such, a Bondholder will need to wait for the calculation period to be completed before
receiving any payment of the Cash Settlement Amount. The calculation of the Cash Settlement Amount will
be affected by share price movements and volatility during this 20 H Share Stock Exchange Business Day
period, which can be affected by a wide array of factors including, without limitation, trade tensions
between the U.S. and China, general market conditions of the securities markets in Hong Kong, the PRC,
the US and elsewhere in the world or economic downturn locally or globally. Please also see “Risk Factors
– Risks relating to the Bonds, the Shares and the offering – Bondholders may only be entitled to the Cash
Settlement Amount”.

Please also see “Risk Factors – Risks relating to the Bonds, the Shares and the offering – The market value
of the Bonds may fluctuate”.

The Bonds will initially be represented by the Global Certificate and holders of a beneficial interest in
the Global Certificate must rely on the procedures of the relevant Clearing System.

The Bonds will initially be represented by the Global Certificate. Such Global Certificate will be deposited
with a common depositary for Euroclear and Clearstream (together the “Clearing Systems” and each a
“Clearing System”). Except in the circumstances described in the Global Certificate, investors will not be
entitled to receive definitive Bonds. The relevant Clearing System will maintain records of the beneficial
interests in the Global Certificate. While the Bonds are represented by the Global Certificate, investors will
be able to trade their beneficial interests only through the Clearing Systems.

While the Bonds are represented by the Global Certificate, the Issuer will discharge its payment obligations
under the Bonds by making payments to the common depositary for Euroclear and Clearstream, for
distribution to their account holders. A holder of a beneficial interest in the Global Certificate must rely on
the procedures of the relevant Clearing System to receive payments under the Bonds. The Issuer has no
responsibility or liability for the records relating to, or payments made in respect of, beneficial interests in
the Global Certificate.

Holders of beneficial interests in the Global Certificate will not have a direct right to vote in respect of the
Bonds. Instead, such holders will be permitted to act only to the extent that they are enabled by the relevant
Clearing System to appoint appropriate proxies.




                                                      65
               TERMS AND CONDITIONS OF THE SERIES 1 BONDS

The following, subject to completion and amendment and other than the words in italics, is the text of the
Terms and Conditions of the Bonds which will appear on the reverse of each of the definitive certificates
evidencing the Bonds:

The issue of US$300,000,000 in aggregate principal amount of zero coupon convertible bonds due 2026 (the
“Bonds”, which term shall include, unless the context requires otherwise, any further Bonds issued in
accordance with Condition 15 and consolidated and forming a single series therewith) of Pharmaron Beijing
Co., Ltd. (the “Issuer”) and the right of conversion into H Shares (as defined in Condition 5.1.5) of the
Issuer were authorised by the general mandate granted to the board of directors of the Issuer by the
shareholders of the Issuer at the annual general meeting of the Issuer held on 28 May 2021 and resolutions
of the board of directors of the Issuer passed on 4 June 2021. The Bonds are constituted by a trust deed (as
amended and/or supplemented from time to time, the “Trust Deed”) to be dated on or about June 18, 2021
(the “Issue Date”) and made between the Issuer and Citicorp International Limited (the “Trustee”, which
term shall, where the context so permits, include all other persons for the time being acting as trustee or
trustees under the Trust Deed) as trustee for the holders of the Bonds. The Issuer has entered into a paying,
conversion and transfer agency agreement (as amended and/or supplemented from time to time, the
“Agency Agreement”) to be dated on or about June 18, 2021 with the Trustee, Citibank, N.A., London
Branch as principal paying agent, principal conversion agent and principal transfer agent (collectively in
such capacities, the “Principal Agent”) and as registrar (the “Registrar”) and the other paying agents,
transfer agents and conversion agents appointed under it (each a “Paying Agent”, a “Transfer Agent” or
a “Conversion Agent” (as applicable) and together with the Registrar and the Principal Agent, the
“Agents”) relating to the Bonds. For the avoidance of doubt, references to the “Paying Agents”, the
“Transfer Agents” or, as the case may be, the “Conversion Agents” each include the Principal Agent.
References to the “Principal Agent”, the “Registrar” and the “Agents” below are references to the principal
agent, the registrar and the agents for the time being for the Bonds. These terms and conditions (the
“Conditions”) include summaries of, and are subject to, the detailed provisions of the Trust Deed and the
Agency Agreement. Unless otherwise defined, terms used in these Conditions have the meanings specified
in the Trust Deed. The Issuer has also entered into a calculation agency agreement (the “Calculation
Agency Agreement”) to be dated on or about June 18, 2021 with Conv-Ex Advisors Limited (the
“Calculation Agent”, which expression shall include any successor as calculation agent under the
Calculation Agency Agreement) whereby the Calculation Agent has been appointed to make certain
calculations in relation to the Bonds. The Bondholders are deemed to have notice of those provisions
applicable to them which are contained in the Calculation Agency Agreement. Copies of the Trust Deed, the
Agency Agreement and of the Calculation Agency Agreement are available for inspection reasonable times
during usual business hours (being between 9.00 a.m. and 3.00 p.m.) at the specified office of the Principal
Agent, being at the date of the Trust Deed at 20th Floor, Citi Tower, One Bay East, 83 Hoi Bun Road, Kwun
Tong, Kowloon, Hong Kong following prior written request and proof of holding and identity satisfactory
to the Principal Agent. The Bondholders (as defined in Condition 1.3) are entitled to the benefit of, are
bound by, and are deemed to have notice of, all the provisions of the Trust Deed and are deemed to have
notice of those provisions of the Agency Agreement and Calculation Agency Agreement applicable to them.

All capitalised terms that are not defined in the Conditions will have the meanings given to them in the Trust
Deed.

1.    Status; Form, Denomination and Title

1.1   Status

      The Bonds constitute direct, unsubordinated, unconditional and (subject to the provisions of
      Condition 3.1) unsecured obligations of the Issuer and shall at all times rank pari passu and without
      any preference or priority among themselves. The payment obligations of the Issuer under the Bonds
      shall, save for such exceptions as may be provided by mandatory provisions of applicable law and
      subject to Condition 3.1, at all times rank at least equally with all of its other present and future direct,
      unsubordinated, unconditional and unsecured obligations.


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1.2   Form and Denomination

      The Bonds are issued in registered form in the specified denomination of U.S.$200,000 each and
      integral multiples of U.S.$100,000 in excess thereof (an “Authorised Denomination”). A bond
      certificate (each a “Certificate”) will be issued to each Bondholder in respect of its registered holding
      of Bonds. Each Certificate will be numbered serially with an identifying number which will be
      recorded on the relevant Certificate and in the register of Bondholders (the “Register”) which the
      Issuer will procure to be kept by the Registrar.

      Upon issue, the Bonds will be represented by a Global Certificate registered in the name of a nominee
      of, and deposited with, a common depositary for Euroclear Bank SA/NV (“Euroclear”), as operator
      of the Euroclear System, and Clearstream Banking S.A. (“Clearstream”). The Conditions are
      modified by certain provisions contained in the Global Certificate.

      Except in the limited circumstances described in the Global Certificate, owners of interests in Bonds
      represented by the Global Certificate will not be entitled to receive definitive Certificates in respect
      of their individual holdings of Bonds. The Bonds are not issuable in bearer form.

1.3   Title

      Title to the Bonds passes only by transfer and registration in the Register as described in Condition 2.
      The holder of any Bond will (except as otherwise required by law or as ordered by a court of
      competent jurisdiction) be treated as its absolute owner for all purposes (whether or not it is overdue
      and regardless of any notice of ownership, trust or any interest in it or any writing on, or the theft or
      loss of, the Certificate issued in respect of it) and no person will be liable for so treating the holder.
      In these Conditions, “Bondholder” and (in relation to a Bond) “holder” means the person in whose
      name a Bond is registered.

2.    Registration and Transfers of Bonds; Issue of Certificates

2.1   Register

      The Issuer will cause the Register to be kept at the specified office of the Registrar outside the United
      Kingdom and in accordance with the terms of the Agency Agreement a register on which shall be
      entered the names and addresses of the holders of the Bonds and the particulars of the Bonds held by
      them and of all transfers, redemptions and conversions of the Bonds. Each Bondholder shall be
      entitled to receive only one Certificate in respect of its entire holding of Bonds.

2.2   Transfers

      Subject to Conditions 2.5 and 2.6 and the terms of the Agency Agreement, a Bond may be transferred
      in whole or in part in an Authorised Denomination by delivery of the Certificate issued in respect of
      that Bond, with the form of transfer on the back duly completed and signed by the holder or his
      attorney duly authorised in writing, to the specified office of the Registrar or of any of the Transfer
      Agents. No transfer of a Bond will be valid or effective unless and until entered on the Register.
      A Bond may be registered only in the name of, and transferred only to, a named person.

      Transfers of interests in the Bonds evidenced by the Global Certificate will be effected in accordance
      with the rules of the relevant clearing systems.




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2.3   Delivery of New Certificates

      2.3.1 Each new Certificate to be issued upon a transfer of Bonds will, within seven business days of
            receipt by the Registrar or, as the case may be, any Transfer Agent of the original Certificate and
            the form of transfer duly completed and signed, be made available for collection at the specified
            office of the Registrar or such Transfer Agent or, if so requested in the form of transfer, be
            mailed by uninsured mail at the risk of the holder entitled to the Bonds (but free of charge to
            the holder and at the Issuer’s expense) to the address specified in the form of transfer. The form
            of transfer is available at the specified office of the Registrar and each Transfer Agent.

           Except in the limited circumstances described herein, the Bonds will only be issued to the
           Bondholders in book-entry form and owners of interests in the Bonds will not be entitled to
           receive physical delivery of Certificates.

      2.3.2 Where only part of a principal amount of the Bonds (being that of one or more Bonds) in respect
            of which a Certificate is issued is to be transferred, converted, redeemed or repurchased, a new
            Certificate in respect of the Bonds not so transferred, converted, redeemed or repurchased will,
            within seven business days of delivery of the original Certificate to the Registrar or any Transfer
            Agent, be made available for collection at the specified office of the Registrar or such Transfer
            Agent or, if so requested in the form of transfer, be mailed by uninsured mail at the risk of the
            holder of the Bonds not so transferred, converted, redeemed or repurchased (but free of charge
            to the holder and at the Issuer’s expense) to the address of such holder appearing on the Register.

      2.3.3 For the purposes of this Condition 2.3, “business day” shall mean a day other than a Saturday
            or Sunday on which banks are open for business in the city in which the specified office of the
            Registrar (if a Certificate is deposited with it in connection with a transfer or conversion) or the
            Transfer Agent with whom a Certificate is deposited in connection with a transfer or conversion,
            is located.

2.4   Formalities Free of Charge

      Registration of a transfer of Bonds and issuance of new Certificates will be effected without charge
      subject to (i) the person making such application for transfer paying or procuring the payment of any
      taxes, duties and other governmental charges in connection therewith, (ii) the Registrar being satisfied
      with the documents of title and/or identity of the person making the application and (iii) such
      regulations as the Issuer may from time to time agree with the Registrar with the prior written
      approval of the Trustee or as the Registrar may promulgate with the prior written approval of the
      Trustee (and as initially set out in the Agency Agreement).

2.5   Restricted Transfer Periods

      No Bondholder may require the transfer of a Bond to be registered (i) during the period of seven days
      ending on (and including) the dates for payment of any principal pursuant to these Conditions;
      (ii) after a Conversion Notice (as defined in Condition 5.2.1) has been delivered with respect to such
      Bond; (iii) after a Put Option Notice (as defined in Condition 7.4) has been deposited in respect of
      such Bond or (iv) after a Relevant Event Put Exercise Notice (as defined in Condition 7.5) has been
      deposited in respect of such Bond, each such period being a “Restricted Transfer Period”.

2.6   Regulations

      All transfers of Bonds and entries on the Register will be made subject to the detailed regulations
      concerning transfer of Bonds scheduled to the Agency Agreement. The regulations may be changed
      by the Issuer, with the prior written approval of the Trustee and the Registrar. A copy of the current
      regulations will be made available (free of charge to the Bondholder and at the Issuer’s expense) by
      the Registrar to any Bondholder following written request and satisfactory proof of holding and
      identity and is available for inspection following written request and proof of holding and identity
      satisfactory to the Registrar at all reasonable times during normal business hours at the specified
      office of the Registrar.


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3.    Covenants

3.1   Negative Pledge

      So long as any Bond remains outstanding (as defined in the Trust Deed), the Issuer will not create or
      permit to subsist, and the Issuer will procure that no Subsidiary (as defined below) will create, or have
      outstanding, any mortgage, charge, pledge, lien or other form of encumbrance or security interest upon
      the whole or any part of its undertaking, assets or revenues (including any uncalled capital), present
      or future, to secure any Investment Securities (as defined below) or to secure any guarantee of or
      indemnity in respect of any Investment Securities unless, at the same time or prior thereto according
      to the Bonds the same security as is created or subsisting to secure any such Investment Securities,
      guarantee or indemnity or such other security as either (i) the Trustee shall in its absolute discretion
      deem not materially less beneficial to the interests of the Bondholders or (ii) shall be approved by an
      Extraordinary Resolution (as defined in the Trust Deed) of the Bondholders.

3.2   Undertakings Relating to Foreign Debt Registration

      The Issuer undertakes that it will (i) within 15 Registration Business Days after the Issue Date,
      register or cause to be registered with SAFE the Bonds pursuant to the Administrative Measures for
      Foreign Debt Registration and its operating guidelines, effective as of 13 May 2013 as amended from
      time to time and the Circular of the People’s Bank of China on Issues Concerning the Overall Macro
      Prudential Management System for Cross-border Financing (
                                 ) (the “Cross-Border Financing Circular”) (the “Foreign Debt
      Registration”), (ii) use its best endeavors to complete the Foreign Debt Registration and obtain a
      registration record from SAFE on or before the Registration Deadline and (iii) comply with all
      applicable PRC laws and regulations in relation to the Bonds, including but not limited to the Foreign
      Debt Registration, the Cross-Border Financing Circular and any implementing measures promulgated
      thereunder from time to time.

3.3   Notification to NDRC

      The Issuer undertakes that it will within 10 Registration Business Days after the Issue Date file or
      cause to be filed with the NDRC the requisite information and documents in accordance with the
      Circular on Promoting the Reform of the Administrative System on the Issuance by Enterprises of
      Foreign Debt Filings and Registrations (
             (         [2015]2044 )) issued by the NDRC and effective as of 14 September 2015 and any
      implementation rules as issued by the NDRC from time to time (the “NDRC Post-issue Filing”).

3.4   Notification of Submission of the NDRC Post-issue Filing and the completion of the Foreign Debt
      Registration

      The Issuer shall on or before the Registration Deadline and within 10 Registration Business Days after
      the later of (i) submission of the NDRC Post-issue Filing and (ii) receipt of the registration certificate
      from SAFE (or any other document evidencing the completion of the Foreign Debt Registration issued
      by SAFE), provide the Trustee with (a) a certificate in English substantially in the form scheduled to
      the Trust Deed signed by an Authorised Signatory (as defined in the Trust Deed) of the Issuer
      confirming the submission of the NDRC Post-issue Filing and the completion of the Foreign Debt
      Registration; and (b) copies of the relevant documents evidencing the NDRC Post-issue Filing and the
      Foreign Debt Registration, each certified in English as a true and complete copy of the original by an
      Authorised Signatory of the Issuer (the items specified in (a) and (b) together, the “Registration
      Documents”). In addition, the Issuer shall, within 10 Registration Business Days after the
      Registration Documents are delivered to the Trustee, give notice to the Bondholders (in accordance
      with Condition 16) confirming the submission of the NDRC Post-issue Filing and the completion of
      the Foreign Debt Registration.


                                                      69
      The Trustee shall have no obligation or duty to monitor or assist with or ensure the NDRC Post-Issue
      Filing is submitted or the Foreign Debt Registration is submitted or completed within the timeframe
      specified in Condition 3.2 and Condition 3.3, respectively, or to verify the accuracy, validity and/or
      genuineness of any documents in relation to or in connection with the NDRC Post-issue Filing and/or
      the Foreign Debt Registration and/or the Registration Documents or to translate or procure the
      translation into English of the documents in relation to or in connection with the NDRC Post-issue
      Filing or the Foreign Debt Registration or to give notice to the Bondholders confirming the completion
      of the NDRC Post-issue Filing and the Foreign Debt Registration, and shall not be liable to
      Bondholders or any other person for not doing so.

3.5   Definitions

      For the purposes of these Conditions:

      “Hong Kong” means the Hong Kong Special Administrative Region of the People’s Republic of
      China;

      “Investment Securities” means any present or future indebtedness incurred outside the PRC in the
      form of, or represented by, bonds, debentures, notes, loan stock, bearer participation certificates,
      depositary receipts, certificates of deposit or other investment securities which represent indebtedness
      and are for the time being, or are intended to be or capable of being, quoted, listed, ordinarily dealt
      in or traded on any stock exchange or over-the-counter or other securities market;

      “NDRC” means the National Development and Reform Commission of the PRC or its local
      counterparts;

      “person” means any individual, corporation, partnership, limited liability company, joint venture,
      trust, unincorporated organisation or government or any agency or political subdivision thereof;

      “PRC” means the People’s Republic of China, which, for the purpose of these Conditions only, shall
      exclude Hong Kong, the Macau Special Administrative Region of the People’s Republic of China and
      Taiwan;

      “Registration Business Day” means a day, other than a Saturday, Sunday or public holiday, on which
      commercial banks are generally open for business in Beijing;

      “Registration Deadline” means the day falling 90 Registration Business Days after the Issue Date;

      “SAFE” means the State Administration of Foreign Exchange of the PRC or its local branch; and

      “Subsidiary” or “subsidiary” means (i) in relation to any person, any company or other business
      entity of which that person owns or controls (either directly or through one or more other Subsidiaries)
      more than 50 per cent. of the registered share capital or issued share capital or other ownership interest
      having ordinary voting power to elect directors, managers or trustees of such company or other
      business entity or (ii) any company or other business entity which at any time has its accounts
      consolidated with those of that person or which, under the laws of Hong Kong or the PRC, or in
      accordance with generally accepted accounting principles applicable in the PRC from time to time,
      should have its accounts consolidated with those of that person.




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4.    Interest

      The Bonds are zero coupon and do not bear interest unless, upon due presentation thereof, payment
      of principal and premium (if any) is improperly withheld or refused. In such event, such unpaid
      amount shall bear interest at the rate of 2 per cent. per annum (both before and after judgment) until
      whichever is the earlier of (a) the day on which all sums due in respect of such Bond up to that day
      are received by or on behalf of the relevant holder and (b) the day falling seven days after the Trustee
      or the Principal Agent has notified Bondholders of receipt of all sums due in respect of all the Bonds
      up to that seventh day (except to the extent that there is failure in the subsequent payment to the
      relevant holders under these Conditions). If interest is required to be calculated for a period of less
      than one year, it will be determined on the basis of a 360-day year consisting of 12 months of 30 days
      each and, in the case of an incomplete month, the number of days elapsed.

5.    Conversion

5.1   Conversion Right

      5.1.1 Conversion Right and Conversion Period: Subject as hereinafter provided and in accordance
            with the provisions of the Trust Deed, Bondholders have the right to convert their Bonds into
            H Shares credited as fully paid at any time during the Conversion Period referred to below. The
            right of a Bondholder to convert any Bond into H Shares is called the “Conversion Right”. The
            number of H Shares to be issued on conversion of a Bond will be determined by the Calculation
            Agent by dividing the principal amount of the Bond to be converted (translated into HK dollars
            at the fixed rate of HK$7.7588 = U.S.$1.00) (the “Fixed Exchange Rate”) by the Conversion
            Price (as defined in Condition 5.1.3) in effect on the Conversion Date (as defined in Condition
            5.2.1). A Conversion Right may only be exercised in respect of an Authorised Denomination for
            one or more Bonds. If more than one Bond held by the same holder is converted at any one time
            pursuant to any one Conversion Notice, the number of H Shares to be issued upon such
            conversion will be calculated on the basis of the aggregate principal amount of the Bonds to be
            converted.

           Subject to and upon compliance with these Conditions (including without limitation Condition
           5.1.4), the Conversion Right attaching to any Bond may be exercised, at the option of the holder
           thereof, at any time on and after 41st day after the Issue Date up to the close of business (at the
           place where the Certificate evidencing such Bond is deposited for conversion) on the date falling
           10 working days prior to the Maturity Date (as defined in Condition 7.1) (both days inclusive)
           or if such Bond shall have been called for redemption by the Issuer before the Maturity Date,
           then up to and including the close of business (at the place aforesaid) on a date no later than 10
           working days (both days inclusive and at the place aforesaid) prior to the date fixed for
           redemption thereof; provided that no Conversion Right may be exercised in respect of a Bond
           where the holder shall have exercised its right to require the Issuer to redeem or repurchase such
           Bond pursuant to Condition 7.4 or Condition 7.5 or during a Restricted Conversion Period (both
           dates inclusive) (as defined below); provided further that the Conversion Right is exercised
           subject to any applicable fiscal or other laws or regulations or as hereafter provided in these
           Conditions (the “Conversion Period”).

           A Conversion Right may not be exercised in relation to any Bond during any period:

           (i)    commencing, for an annual shareholder general meeting of the Issuer, on the date falling
                  20 days prior to that meeting and ending on the date of that meeting, or, for an
                  extraordinary shareholder general meeting of the Issuer, on the date falling 15 days prior
                  to that meeting and ending on the date of that meeting;

           (ii)   commencing the date falling five working days prior to the record date set by the Issuer
                  for the purpose of distribution of any dividend and ending on such record date; or


                                                     71
     (iii) commencing on such date and for such period as determined by applicable law from time
           to time that the Issuer is required to close its register,

     (each of the periods set out in (i), (ii) and (iii) above, subject as provided in the following
     paragraph, a “Restricted Conversion Period”).

     The Issuer will give notice of any such Restricted Conversion Period to the Bondholders (in
     accordance with Condition 16) and the Trustee and Agents not less than five working days prior
     to the commencement of any such Restricted Conversion Period, failing which the relevant
     Restricted Conversion Period shall not apply.

     For the purpose of this Condition 5.1.1, “working day” means a day other than a Saturday,
     Sunday or a public holiday on which commercial banks and foreign exchange markets are open
     for business in London.

5.1.2 Fractions of H Shares: Fractions of H Shares will not be issued on conversion and no cash
      payments or other adjustments will be made in lieu thereof. However, if the Conversion Right
      in respect of more than one Bond is exercised pursuant to any one Conversion Notice, the
      number of such H Shares to be issued in respect thereof shall be calculated by the Calculation
      Agent on the basis of the aggregate principal amount of such Bonds being so converted and
      rounded down to the nearest whole number of H Shares.

     Notwithstanding the foregoing, in the event of a consolidation or re-classification of H Shares
     by operation of law or otherwise occurring after June 8, 2021 which reduces the number of H
     Shares outstanding, the Issuer will upon conversion of Bonds, in respect of which the
     Registration Date falls after the record date or other due date for the establishment of entitlement
     for such consolidation or re-classification, pay a sum (but only if such sum exceeds
     U.S.$100.00) in cash in U.S. dollars (by means of a U.S. dollar cheque drawn on a bank that
     processes payments in U.S. dollars or by transfer to a U.S. dollar account maintained by the
     payee) in either case in accordance with instructions given by the relevant Bondholder in the
     Conversion Notice, and no later than five Payment Business Days following the Conversion
     Date (or, in the case of Additional H Shares, the Reference Date) equal to the product of (i) the
     fraction of any H Share not delivered pursuant to the above paragraph and (ii) the Volume
     Weighted Average Price of an H Share converted if necessary into U.S. dollars at the Prevailing
     Rate on the relevant Conversion Date, as determined by the Calculation Agent.

5.1.3 Conversion Price: The price at which H Shares will be issued upon conversion (the “Conversion
      Price”) will initially be HK$250.75 per H Share but will be subject to adjustment in the manner
      provided in Condition 5.3, subject as provided in Condition 5.6.

5.1.4 Revival and/or survival after Default: Notwithstanding the provisions of Condition 5.1.1, if (i)
      the Issuer shall default in making payment in full in respect of any Bond which shall have been
      called or put for redemption on the date fixed for redemption thereof, (ii) any Bond has become
      due and payable prior to the Maturity Date by reason of the occurrence of any of the events
      referred to in Condition 9 or (iii) any Bond is not redeemed on the Maturity Date in accordance
      with Condition 7.1, the Conversion Right attaching to such Bond will revive and/or will continue
      to be exercisable up to, and including, the close of business (at the place where the Certificate
      evidencing such Bond is deposited for conversion) on the date upon which the full amount of
      the moneys payable in respect of such Bond has been duly received by the Principal Agent or
      the Trustee and notice of such receipt has been duly given to the Bondholders in accordance with
      Condition 16 and, notwithstanding the provisions of Condition 5.1.1, any Bond in respect of
      which the Certificate and Conversion Notice are deposited for conversion prior to such date shall
      be converted on the relevant Conversion Date notwithstanding that the full amount of the
      moneys payable in respect of such Bond shall have been received by the Principal Agent or the
      Trustee before such Conversion Date or that the Conversion Period may have expired before
      such Conversion Date.


                                               72
    5.1.5 Meaning of H Shares, A Shares, Ordinary Shares: As used in these Conditions, the expression
          (i) “H Shares” means ordinary foreign shares with a par value of RMB1.00 each issued by the
          Issuer which are traded in HK dollars on the Hong Kong Stock Exchange
          (ISIN: CNE100003PG4); (ii) “A Shares” means ordinary domestic shares of RMB1.00 each
          issued by the Issuer which are traded in Renminbi on the Shenzhen Stock Exchange; and
          (iii) “Ordinary Shares” means the H Shares, the A Shares and any fully-paid and non-assessable
          shares of any class or classes of the ordinary shares of the Issuer authorised after the date of the
          issue of the Bonds which have no preference in respect of dividends or of amounts payable in
          the event of any voluntary or involuntary liquidation or dissolution of the Issuer.

Conversion Procedure

    5.1.6 Conversion Notice: Conversion Rights may be exercised by a Bondholder during the Conversion
          Period by delivering the relevant Certificate to the specified office of any Conversion Agent
          during its usual business hours (being 9:00 a.m. to 3:00 p.m., Monday to Friday on which
          commercial banks are open for business in the city of the specified office of the Conversion
          Agent) accompanied by a duly completed and signed notice of conversion (a “Conversion
          Notice”) in the form (for the time being current and being substantially in the form scheduled
          to the Agency Agreement) obtainable from any Conversion Agent, together with (i) the relevant
          Certificate; and (ii) certification by the Bondholder, in the form obtainable from any Conversion
          Agent, as may be required under the laws of the PRC, Hong Kong or any jurisdiction in which
          the specified office of such Conversion Agent is located. Conversion Rights shall be exercised
          subject in each case to any applicable fiscal or other laws or regulations applicable in the
          jurisdiction in which the specified office of the Conversion Agent to whom the relevant
          Conversion Notice is delivered is located.

         Holders of beneficial interests in the Global Certificate may exercise Conversion Rights through
         the holder of the Global Certificate in accordance with the rules of the applicable clearing
         system.

         If such delivery is made after 3.00 p.m. on any business day or on a day which is not a business
         day, in each case in the place of the specified office of the Conversion Agent, such delivery shall
         be deemed for all purposes of these Conditions to have been made on the next business day
         following such day. If such delivery is made during a Restricted Conversion Period, such
         delivery shall be deemed for all purposes of these Conditions to have been made on the business
         day following (in the place of the specified office of the Conversion Agent) the last day of such
         Restricted Conversion Period unless such date shall fall outside the Conversion Period.

         Any determination as to whether any Conversion Notice has been duly completed and properly
         delivered shall be made by the relevant Conversion Agent and shall, save in the case of manifest
         error, be conclusive and binding on the Issuer, the Trustee, the Agents and the relevant
         Bondholder.

         A Conversion Notice, once delivered, shall be irrevocable and may not be withdrawn without the
         Issuer’s consent.

         The conversion date in respect of a Bond (the “Conversion Date”) shall be deemed to be the H
         Share Stock Exchange Business Day (as defined in Condition 5.8) immediately following the
         date on which delivery of the Certificate in respect of such Bond and such Conversion Notice
         (and, if applicable, any such certificate) is made (or deemed to be made) as provided above is
         so made or given).




                                                    73
5.1.7 Stamp Duty etc.: A Bondholder delivering a Certificate in respect of a Bond for conversion must
      pay directly to the relevant authorities or party any taxes and duties, including capital, stamp,
      issue, excise, transfer, registration and other similar taxes and duties and transfer costs
      (“Duties”) in any applicable jurisdiction arising on conversion (other than any Duties payable
      in the PRC or Hong Kong or, if relevant, in the place of the Alternative Stock Exchange, by the
      Issuer in respect of the allotment and issue of H Shares and listing of the H Shares on the Hong
      Kong Stock Exchange or the Alternative Stock Exchange (as the case may be) on conversion,
      such Duties being the “Issuer Duties”) (such Duties and Issuer Duties are collectively known
      as “Taxes”). The Issuer will pay all other expenses arising from the issue of H Shares on
      conversion of the Bonds and all charges (together, the “Conversion Expenses”) of the Agents
      and the share transfer agent for the H Shares (the “Share Transfer Agent”). The Bondholder
      (and, if different, the person to whom the H Shares are to be issued) must declare in the relevant
      Conversion Notice that any amounts payable to the relevant tax authorities or party in settlement
      of Duties (other than the Issuer Duties) payable pursuant to this Condition 5.2.2 have been paid.

     If the Issuer fails to pay any Issuer Duties or Conversion Expenses, the relevant holder shall be
     entitled to tender and pay the same and the Issuer, as a separate and independent stipulation,
     covenants to reimburse and indemnify each Bondholder in respect of any payment thereof and
     any penalties payable in respect thereof.

     Such Bondholder must also pay all, if any, Duties (other than Issuer Duties) imposed on it and
     arising by reference to any disposal or deemed disposal of a Bond or interest therein in
     connection with the exercise of Conversion Rights by it.

     Neither the Trustee nor the Agents shall be responsible for determining whether such Taxes or
     Conversion Expenses are payable or the amount thereof and shall not be responsible or liable for
     any failure by the Issuer or any Bondholder to pay any such amount.

5.1.8 Delivery of H Shares Upon Conversion, Registration, Retroactive Adjustments:

     (i)   As soon as practicable, and in any event not later than seven H Share Stock Exchange
           Business Days (excluding any H Share Stock Exchange Business Day that falls within a
           Restricted Conversion Period) after the relevant Conversion Date (or, in the case of
           Additional H Shares, the relevant Reference Date), the Issuer will, in the case of Bonds
           converted on exercise of the Conversion Right and in respect of which a duly completed
           Conversion Notice has been delivered and the relevant Certificate and certification and
           amounts payable by the relevant Bondholder deposited or paid as required by Conditions
           5.2.1 and 5.2.2, register the person designated for the purpose in the Conversion Notice as
           holder of the relevant number of H Shares in the Issuer’s H share register and will, if such
           Bondholder has so requested in such Conversion Notice and to the extent permitted under
           applicable law and the rules and procedures of the Central Clearing and Settlement System
           of Hong Kong (“CCASS”) effective from time to time, take all action reasonably necessary
           to enable the H Shares to be delivered through CCASS for so long as the H Shares are
           listed on the Hong Kong Stock Exchange; or will make such certificate or certificates
           available for collection at the office of the Issuer’s share registrar in Hong Kong (being,
           at the time of issue of the Bonds, Computershare Hong Kong Investor Services Limited at
           Shops 1712-1716, 17th Floor, Hopewell Centre, 183 Queen’s Road East, Hong Kong)
           notified to Bondholders in accordance with Condition 16 or, if so requested in the relevant
           Conversion Notice, cause its share registrar to mail (at the risk, and, if sent at the request
           of such person otherwise than by ordinary mail, at the expense, of the person to whom such
           certificate or certificates are sent) such certificate or certificates to the person and at the
           place specified in the Conversion Notice, together (in either case) with any other securities,
           property or cash required to be delivered upon conversion and such assignments and other
           documents (if any) as may be required by law to effect the transfer thereof.


                                                74
     (ii)   The delivery of the H Shares to the converting Bondholder (or such person designated in
            the relevant Conversion Notice) in the manner contemplated in Condition 5.2.3(i) will be
            deemed to satisfy the Issuer’s obligation to pay any amounts under such converted Bonds.
            The person designated in the Conversion Notice will become the holder of record of the
            number of H Shares issuable upon conversion with effect from the date he is registered as
            such in the Issuer’s register of members for H shares (the “Registration Date”, or, in the
            case of Additional H Shares, the “Additional Registration Date”, in each case in respect
            of such exercise of Conversion Rights). The H Shares issued upon exercise of the
            Conversion Rights will be fully paid up and will in all respects rank pari passu with, and
            within the same class as, the H Shares in issue on the relevant Registration Date (or, in the
            case of Additional H Shares, the Additional Registration Date) except for any right
            excluded by mandatory provisions of applicable law. Save as set out in these Conditions,
            a holder of H Shares issued on exercise of the Conversion Rights shall not be entitled to
            any rights, distributions or other payments the record date or due date for the establishment
            of entitlement for which precedes the relevant Registration Date (or, in the case of
            Additional H Shares, the Additional Registration Date). Notwithstanding the foregoing,
            where the Cash Settlement Option has been exercised and the number of Cash Settled H
            Shares is equal to the number of Reference H Shares in respect of the relevant exercise of
            Conversion Rights, the “Registration Date” in respect thereof shall be date falling seven
            H Share Stock Exchange Business Days (excluding any H Share Stock Exchange Business
            Day that falls within a Restricted Conversion Period) after the relevant Conversion Date.

     (iii) If (A) the Registration Date in relation to any exercise of Conversion Rights shall be after
           the Applicable RA Date in respect of any adjustment to the Conversion Price pursuant to
           Condition 5.3 and (B) the Conversion Date in relation to such exercise shall be before the
           date on which such adjustment to the Conversion Price becomes effective under the
           relevant Condition (any such adjustment, a “Retroactive Adjustment”), upon the relevant
           adjustment to the Conversion Price becoming effective under the relevant Condition the
           Issuer shall procure the issue to the converting Bondholder (in accordance with the
           instructions contained in the Conversion Notice (subject to any applicable laws or
           regulations)), such additional number of H Shares (“Additional H Shares”) as, together
           with the Physically Settled H Shares issued or to be issued on conversion of the relevant
           Bond, is equal to the number of Physically Settled H Shares which would have been
           required to be issued on conversion of such Bond if the relevant adjustment to the
           Conversion Price under the relevant Condition had been effective on the relevant
           Conversion Date (such number of Physically Settled H Shares as aforesaid being for this
           purpose calculated as (i) where the Cash Settlement Option has not been exercised in
           respect of such exercise of Conversion Rights, the Reference H Shares in respect of such
           exercise of Conversion Rights determined for this purpose by reference to such deemed
           Conversion Price as aforesaid, and (ii) where the Cash Settlement Option has been
           exercised in respect of such exercise of Conversion Rights, the difference between (A)
           such number of Reference H Shares as is determined pursuant to (i) above and (B) the
           product of (x) such number of Reference H Shares determined as aforesaid and (y) the
           Cash Settlement Ratio in respect of such exercise of Conversion Rights), all as determined
           by the Calculation Agent.

5.1.9 Cash Settlement Option: Notwithstanding the Conversion Right of each Bondholder in respect
      of each Bond, at any time when the delivery of H Shares deliverable upon conversion of the
      Bond is required to satisfy the Conversion Right in respect of a Conversion Notice, the Issuer
      shall have the option, in its sole discretion, to pay to the relevant Bondholder an amount of cash
      equivalent to the Cash Settlement Amount in order to satisfy such Conversion Right in whole or
      in part (and if in part, the other part shall be satisfied by the delivery of H Shares) (the “Cash
      Settlement Option”). In order to exercise the Cash Settlement Option, the Issuer shall provide
      notice of the exercise of the Cash Settlement Option (the “Cash Settlement Notice”) to the
      relevant Bondholder (by email to the relevant email address specified for this purpose by such
      Bondholder in the relevant Conversion Notice), the Trustee, the Calculation Agent and the
      Agents no later than the Cash Settlement Notice Date.


                                                75
The Cash Settlement Notice shall be irrevocable and must specify:

(i)    the Conversion Price in effect on the relevant Conversion Date and the number of Reference H
       Shares in respect of such exercise of Conversion Rights;

(ii)   the number of Cash Settled H Shares in respect of such exercise of Conversion Rights, by
       reference to which the Cash Settlement Amount is to be calculated; and

(iii) if the number of Cash Settled H Shares is less than the number of Reference H Shares in respect
      of the relevant exercise of Conversion Rights, the number of Physically Settled H Shares to be
      issued by the Issuer to the relevant Bondholder in respect of such exercise of Conversion Rights.

The Issuer shall pay the Cash Settlement Amount no later than five Payment Business Days following
the last day of the Cash Settlement Calculation Period. The Cash Settlement Amount shall be paid by
the Issuer by means of a U.S. dollar cheque drawn on, or by transfer to a U.S. dollar account
maintained by the payee with, a bank that processes payments in U.S. dollars in accordance with the
instructions given by the relevant Bondholder in the relevant Conversion Notice.

For the purposes of these Conditions:

“Cash Settled H Shares” means, in respect of an exercise of Conversion Rights by a Bondholder in
respect of which the Issuer has exercised the Cash Settlement Option, such number of H Shares (which
shall be a whole number of H Shares and shall not exceed the number of Reference H Shares in respect
of such exercise) as determined by the Issuer and notified to the relevant Bondholder in the relevant
Cash Settlement Notice.

“Cash Settlement Notice Date” means the fifth H Share Stock Exchange Business Day following the
relevant Conversion Date.

“Cash Settlement Amount” means, in respect of any exercise of Conversion Rights in respect of
which the Issuer has exercised the Cash Settlement Option, an amount in U.S. dollars (rounded to the
nearest whole multiple of 0.01 U.S. dollars, with 0.005 U.S. dollars being rounded upwards)
calculated by the Calculation Agent in accordance with the following formula and which shall be
payable by the Issuer to a Bondholder in respect of the relevant Cash Settled H Shares specified in
the relevant Cash Settlement Notice:

where:

                                             N
                                                   1
                                     CSA =             × CSS × Pn
                                                   N
                                             n=1

CSA        =      the Cash Settlement Amount;

CSS        =      the Cash Settled H Shares;

Pn         =      the Volume Weighted Average Price of one H Share (converted if necessary into
                  U.S. dollars at the Prevailing Rate) on the n-th H Share Stock Exchange
                  Business Day of the Cash Settlement Calculation Period; and

N          =      20, being the number of H Share Stock Exchange Business Days in the Cash
                  Settlement Calculation Period,



                                                 76
      provided that:

      (a)   if any dividend, distribution or other entitlement in respect of the H Shares is announced,
            (whether on or prior to or after the relevant Conversion Date) in circumstances where the record
            date or other due date for the establishment of entitlement of holders of H Shares in respect of
            such dividend, distribution or other entitlement shall be on or after the relevant Registration Date
            and if on any H Share Stock Exchange Business Day in the Cash Settlement Calculation Period
            the Volume Weighted Average Price is based on a price ex- such dividend, distribution or other
            entitlement, then such Volume Weighted Average Price shall be increased by an amount equal to
            the Fair Market Value of any such dividend, distribution or other entitlement per H Share as at
            the Ex-Date in respect of such dividend, distribution or other entitlement, all as determined by
            the Calculation Agent, provided that where such Fair Market Value as aforesaid cannot be
            determined in accordance with these Conditions on or before the last day of the relevant Cash
            Settlement Calculation Period, the relevant Volume Weighted Average Price as aforesaid shall be
            adjusted in such manner as determined to be appropriate by an Independent Financial Advisor
            no later than such last day of the Cash Settlement Calculation Period as aforesaid;

      (b)   if a Retroactive Adjustment occurs in relation to the relevant exercise of Conversion Rights and
            if any H Share Stock Exchange Business Day comprised in the Cash Settlement Calculation
            Period in respect of such exercise of Conversion Rights falls on or after the Applicable Date, the
            Volume Weighted Average Price on any such H Share Stock Exchange Business Day shall be
            divided by the adjustment factor (as determined pursuant to these Conditions) applied to the
            Conversion Price in respect of the relevant Retroactive Adjustment, all as determined by the
            Calculation Agent, provided that where such adjustment factor as aforesaid cannot be
            determined in accordance with these Conditions on or before the last day of the relevant Cash
            Settlement Calculation Period, the relevant Volume Weighted Average Price as aforesaid shall be
            adjusted in such manner as determined to be appropriate by an Independent Financial Advisor
            no later than such last day of the Cash Settlement Calculation Period as aforesaid; and

      (c)   if any doubt shall arise as to the calculation of the Cash Settlement Amount or if such amount
            cannot be determined as provided above, the Cash Settlement Amount shall be equal to such
            amount as is determined in such other manner as an Independent Financial Advisor shall
            consider to be appropriate to give the intended result.

      If the Issuer is at any time otherwise (for any reason whatsoever) unable to issue sufficient H Shares
      in satisfaction of the Conversion Right of any converting Bondholder, the Issuer undertakes to
      exercise the Cash Settlement Option in full, or to the extent required, to satisfy the Conversion Right
      of such Bondholder.

5.2   Adjustments to Conversion Price

      Upon the occurrence of any of the events described below, the Conversion Price shall be adjusted as
      follows:

      5.2.1 Consolidation, Subdivision or Re-classification: If and whenever there shall be an alteration to
            the nominal value of the H Shares as a result of consolidation, subdivision or re-classification,
            the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately
            before such alteration by the following fraction:

                                                           A
                                                           B

            Where:

            A    is the nominal amount of one H Share immediately after such alteration; and

            B    is the nominal amount of one H Share immediately before such alteration.

            Such adjustment shall become effective on the date that such consolidation, subdivision or
            re-classification takes effect.


                                                      77
5.2.2 Capitalisation of Profits or Reserves:

     (i)    If and whenever the Issuer shall issue Ordinary Shares of any class credited as fully paid
            to the holders of such Ordinary Shares (“Ordinary Shareholders”) by way of
            capitalisation of profits or reserves, including Ordinary Shares of such class paid up out of
            distributable profits or reserves and/or share premium account (except any Scrip
            Dividend), the Conversion Price shall be adjusted by multiplying the Conversion Price in
            force immediately before such issue by the following fraction:

                                                       A
                                                       B

            Where:

            A    is the aggregate nominal amount of the issued Ordinary Shares immediately before
                 such issue; and

            B    is the aggregate nominal amount of the issued Ordinary Shares immediately after
                 such issue.

            Where (i) such issue is made in respect of more than one class of Ordinary Shares, (ii) any
            such class of Ordinary Shares is the H Shares class, and (iii) there is a record date or other
            due date for the establishment of entitlement for such issue in respect of the H Shares, such
            date shall be deemed to be the record date in respect of such offer for the purpose of these
            Conditions.

            Such adjustment shall become effective on the date of issue of such Ordinary Shares or if
            a record date is fixed therefor, immediately after such record date (or, if later, the first date
            on which the fraction above is capable of being determined in accordance with these
            Conditions).

     (ii)   In the case of an issue of Ordinary Shares of any class by way of a Scrip Dividend where
            the Current Market Price on the date of announcement of the terms of such issue of
            Ordinary Shares (for the purpose of this Condition 5.3.2(ii), the “Determination Date”)
            multiplied by the number of Scrip Dividend issued exceeds 105 per cent. of the amount of
            the Relevant Cash Dividend or the relevant part thereof and which would not have
            constituted a Capital Distribution, the Conversion Price shall be adjusted by multiplying
            the Conversion Price in force immediately before the issue of such Scrip Dividend by the
            following fraction:

                                                           A + B
                                                           A + C

            Where:

            A    is the aggregate nominal amount of the issued Ordinary Shares of all classes
                 immediately before the Determination Date;

            B    is the aggregate nominal amount of such Scrip Dividend multiplied by a fraction of
                 which (i) the numerator is the amount of the whole, or the relevant part, of the
                 Relevant Cash Dividend and (ii) the denominator is such aggregate Current Market
                 Price of the Scrip Dividend issued in lieu of the whole, or the relevant part, of the
                 Relevant Cash Dividend; and

            C    is the aggregate nominal amount of such Scrip Dividend,


                                                  78
           or (at the Issuer’s sole discretion, following consultation with the Calculation Agent) by
           making such other adjustment to the Conversion Price as determined to be appropriate by
           an Independent Financial Advisor.

           Where (i) such issue is made in respect of more than one class of Ordinary Shares, (ii) any
           such class of Ordinary Shares is the H Shares class, and (iii) there is a record date or other
           due date for the establishment of entitlement for such issue in respect of the H Shares, such
           date shall be deemed to be the record date in respect of such offer for the purpose of these
           Conditions.

           Such adjustment shall become effective on the date of issue of such Ordinary Shares or if
           a record date is fixed therefor, immediately after such record date (or, if later, the first date
           on which the fraction above is capable of being determined in accordance with these
           Conditions).

5.2.3 Capital Distributions: If and whenever the Issuer shall pay or make any Capital Distribution to
      the Ordinary Shareholders (except to the extent that the Conversion Price falls to be adjusted
      under Condition 5.3.2 above), the Conversion Price shall be adjusted by multiplying the
      Conversion Price in force immediately before such Capital Distribution by the following
      fraction:

                                                   A – B
                                                     A

     Where:

     A     is the sum of the products of, in respect of each of the classes of Ordinary Shares in issue
           immediately prior to the Determination Date, (i) the number of Ordinary Shares of such
           class in issue on the Determination Date and (ii) the Current Market Price per Ordinary
           Share of such class on the date on which the Capital Distribution is first publicly
           announced (for the purpose of this Condition 5.3.3, the “Determination Date”); and

     B     is the aggregate Fair Market Value of the aggregate Capital Distribution in respect of each
           such class of Ordinary Shares.

     Where (i) such Capital Distribution is paid or made in respect of more than one class of Ordinary
     Shares, (ii) any such class of Ordinary Shares is the H Shares class, and (iii) there is a record
     date or other due date for the establishment of entitlement for such Capital Distribution in
     respect of the H Shares, such date shall be deemed to be the record date in respect of such Capital
     Distribution for the purpose of these Conditions.

     Such adjustment shall become effective on the date that such Capital Distribution is actually
     made or, if a record date is fixed therefor, immediately after such record date (or, if later, the
     first date on which the fraction above is capable of being determined in accordance with these
     Conditions).

     For the purpose of the above, Fair Market Value shall (subject as provided in the definition of
     “Fair Market Value” (as defined in Condition 5.8)) be determined as at the Determination Date.
     In making any calculation pursuant to this Condition 5.3.3, such adjustments (if any) shall be
     made as an Independent Financial Advisor (or, if the Calculation Agent determines in its sole
     discretion it is capable of making such determination in its capacity as Calculation Agent, the
     Calculation Agent) may consider appropriate to reflect (i) any consolidation or subdivision of
     the Ordinary Shares, (ii) issues of Ordinary Shares by way of capitalisation of profits or reserves,
     or any like or similar event or (iii) the modification of any rights to dividends of Ordinary
     Shares.


                                                 79
5.2.4 Rights Issues of Shares or Options over Shares: If and whenever the Issuer shall issue Ordinary
      Shares of one or more classes to all or substantially all Ordinary Shareholders of such classes
      by way of rights, or issue or grant to all or substantially all Ordinary Shareholders of such
      classes by way of rights, options, warrants or other rights to subscribe for, purchase or otherwise
      acquire any Ordinary Shares of such classes, in each case at a consideration less than 95 per cent.
      of the Current Market Price per H Share on the date of the first public announcement of the terms
      of the issues or grants (for the purpose of this Condition 5.3.4, the “Determination Date”), the
      Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately
      before such issues or grants by the following fraction:

                                                A + B 1+ B 2
                                                A + C 1+ C 2

     Where:

     A     is the aggregate number of Ordinary Shares of all classes in issue immediately before the
           Determination Date;

     B1    is the number of Ordinary Shares of one class which the aggregate consideration (if any)
           receivable for the Ordinary Shares of such class issued by way of rights or for the options
           or warrants or other rights issued or granted by way of rights and for the total number of
           Ordinary Shares of such class comprised therein would subscribe for, purchase or
           otherwise acquire at such Current Market Price;

     B2    where applicable, is the number of Ordinary Shares of a second class which the aggregate
           consideration (if any) receivable for the Ordinary Shares of such class issued by way of
           rights or for the options or warrants or other rights issued or granted by way of rights and
           for the total number of Ordinary Shares of such class comprised therein would subscribe
           for, purchase or otherwise acquire at such Current Market Price;

     C1    is the aggregate number of Ordinary Shares of one class to be issued or, as the case may
           be, the maximum number of Ordinary Shares of such class which may be issued upon
           exercise of such options, warrants or rights calculated as at the date of issue of such
           options, warrants or rights in respect thereof at the initial subscription, purchase or
           acquisition price or rate; and

     C2    where applicable, is the aggregate number of Ordinary Shares of a second class issued or,
           as the case may be, the maximum number of Ordinary Shares of such class which may be
           issued upon exercise of such options, warrants or rights calculated as at the date of issue
           of such options, warrants or rights in respect thereof at the initial subscription, purchase
           or acquisition price or rate.

     Where (i) such issue or grant is made in respect of more than one class of Ordinary Shares,
     (ii) any such class of Ordinary Shares is the H Shares class, and (iii) there is a record date or
     other due date for the establishment of entitlement for such issue or grant in respect of the H
     Shares, such date shall be deemed to be the record date in respect of such issue or grant for the
     purpose of these Conditions.

     Such adjustment shall become effective on the date of issue of such Ordinary Shares or issue or
     grant of such options, warrants or other rights (as the case may be) or, where if a record date is
     fixed therefor, immediately after such record date (or, if later, the first date on which the fraction
     above is capable of being determined in accordance with these Conditions).



                                                80
5.2.5 Rights Issues of Other Securities: In respect of each class of Ordinary Shares, if and whenever
      the Issuer shall issue any securities (other than Ordinary Shares or options, warrants or other
      rights to subscribe for, purchase or otherwise acquire Ordinary Shares) to all or substantially all
      Ordinary Shareholders of such class by way of rights, or issue or grant to all or substantially all
      Ordinary Shareholders of such class by way of rights, options, warrants or other rights to
      subscribe for, purchase or otherwise acquire any securities (other than Ordinary Shares or
      options, warrants or other rights to subscribe for, purchase or otherwise acquire Ordinary
      Shares), the Conversion Price shall be adjusted by multiplying the Conversion Price in force
      immediately before such issue or grant by the following fraction:

                                                  A – B
                                                    A

     Where:

     A     is the sum of the products of, in respect of each of the classes of Ordinary Shares classes
           in issue immediately prior to the Determination Date, (i) the number of Ordinary Shares
           of such class and (ii) the Current Market Price per Ordinary Share of such class on the date
           on which the terms of such issue or grant are first publicly announced (for the purpose of
           this Condition 5.3.5, the “Determination Date”); and

     B     is the aggregate Fair Market Value of the aggregate securities, rights, options or warrants
           (as the case may be) attributable to the Ordinary Shares in respect of each such class of
           Ordinary Shares.

     Where (i) such issue or grant is made in respect of more than one class of Ordinary Shares,
     (ii) any such class of Ordinary Shares is the H Shares class, and (iii) there is a record date or
     other due date for the establishment of entitlement for such issue or grant in respect of the
     H Shares, such date shall be deemed to be the record date in respect of such issue or grant for
     the purpose of these Conditions.

     Such adjustment shall become effective on the date of issue of the securities or the issue or grant
     of such rights, options or warrants (as the case may be) or where a record date is fixed therefor,
     immediately after such record date (or, if later, the first date on which the fraction above is
     capable of being determined in accordance with these Conditions).

     For the purpose of the above, Fair Market Value shall (subject as provided in the definition of
     “Fair Market Value” (as defined in Condition 5.8)) be determined as at the Determination Date.

5.2.6 Issues at Less than Current Market Price: If and whenever the Issuer shall issue (otherwise than
      as mentioned in Condition 5.3.4 above) wholly for cash or for no consideration any Ordinary
      Shares of one or more classes (other than H Shares issued on the exercise of Conversion Rights
      or on the exercise of any other rights of conversion into, or exchange or subscription for,
      Ordinary Shares) or issue or grant (otherwise than as mentioned in Condition 5.3.4 above)
      wholly for cash or for no consideration options, warrants or other rights to subscribe for,
      purchase or otherwise acquire Ordinary Shares of one or more classes, in each case at a
      consideration which is less than 95 per cent. of the Current Market Price per H Share on the date
      of announcement of the terms of such issues (for the purpose of this Condition 5.3.6, the
      “Determination Date”), the Conversion Price shall be adjusted by multiplying the Conversion
      Price in force immediately before such issues by the following fraction:

                                               A + B1 + B2
                                               A + C1 + C2

     Where:

     A     is the aggregate number of Ordinary Shares of all classes in issue immediately before the
           Determination Date;


                                                81
     B1    is the number of Ordinary Shares of one class which the aggregate consideration (if any)
           receivable for the issue of such additional Ordinary Shares of such class would purchase
           at such Current Market Price;

     B2    where applicable, is the number of Ordinary Shares of a second class which the aggregate
           consideration (if any) receivable for the issue of such additional Ordinary Shares of such
           class would purchase at such Current Market Price;

     C1    is the aggregate number of Ordinary Shares of one class issued, or as the case may be, the
           maximum number of Ordinary Shares of such class to be issued on the exercise of such
           options, warrants or other rights at the initial exercise price or rate; and

     C2    where applicable, is the aggregate number of Ordinary Shares of a second class issued, or
           as the case may be, the maximum number of Ordinary Shares of such class to be issued on
           the exercise of such options, warrants or other rights at the initial exercise price or rate.

     References to “additional Ordinary Shares” in the above formula shall, in the case of an issue
     by the Issuer of options, warrants or other rights to subscribe or purchase Ordinary Shares, mean
     such Ordinary Shares to be issued assuming that such options, warrants or other rights are
     exercised in full at the initial exercise price or rate on the date of issue or grant of such options,
     warrants or other rights.

     Where (i) such issue comprises more than one class of Ordinary Shares (or, options, warrants or
     other rights to subscribe for, purchase or otherwise acquire Ordinary Shares of more than one
     class) and (ii) any such class of Ordinary Shares is the H Shares class, the date of issue of such
     Ordinary Shares (or, as the case may be, the date of issue or grant of such options, warrants or
     other rights) shall be deemed to be the date of issue of the H Shares (or, as the case may be, the
     date of issue or grant of the options, warrants or other rights to subscribe for, purchase or
     otherwise acquire H Shares) for the purpose of these Conditions.

     Such adjustment shall become effective on the date of issue of such additional Ordinary Shares
     or, as the case may be, the issue or grant of such options, warrants or other rights (or, if later,
     the first date on which the fraction above is capable of being determined in accordance with
     these Conditions).

5.2.7 Other Issues at less than Current Market Price: Save in the case of an issue of securities arising
      from a conversion or exchange of other securities in accordance with the terms applicable to
      such securities themselves falling within this Condition 5.3.7, if and whenever the Issuer or any
      of its Subsidiaries (otherwise than as mentioned in Condition 5.3.4, Condition 5.3.5 or Condition
      5.3.6), or (at the direction or request of or pursuant to any arrangements with the Issuer or any
      of its Subsidiaries) any other company, person or entity shall issue any securities wholly for cash
      or for no consideration (other than the Bonds, which shall be deemed to exclude any further
      bonds issued pursuant to Condition 15) which by their terms of issues carry rights of conversion
      into, or exchange or subscription for, Ordinary Shares of one or more classes to be issued by the
      Issuer upon conversion, exchange or subscription, in each case at a consideration which is less
      than 95 per cent. of the Current Market Price per H Share on the date of announcement of the
      terms of issues of such securities (for the purpose of this Condition 5.3.7, the “Determination
      Date”), the Conversion Price shall be adjusted by multiplying the Conversion Price in force
      immediately before such issues by the following fraction:

                                                A + B1 + B2
                                                A + C1 + C2

     Where:

     A     is the aggregate number of Ordinary Shares of all classes in issue immediately before the
           Determination Date;


                                                82
     B1    is the number of Ordinary Shares of one class which the aggregate consideration receivable
           by the Issuer for the Ordinary Shares of such class to be issued on conversion or exchange
           or on exercise of the right of subscription attached to such securities would purchase at
           such Current Market Price;

     B2    where applicable, is the number of Ordinary Shares of a second class which the aggregate
           consideration receivable by the Issuer for the Ordinary Shares of such class to be issued
           on conversion or exchange or on exercise of the right of subscription attached to such
           securities would purchase at such Current Market Price;

     C1    is the maximum number of Ordinary Shares of one class to be issued on conversion or
           exchange of such securities or on the exercise of such rights of subscription attached
           thereto at the initial conversion, exchange or subscription price or rate; and

     C2    where applicable, is the maximum number of Ordinary Shares of a second class to be
           issued on conversion or exchange of such securities or on the exercise of such rights of
           subscription attached thereto at the initial conversion, exchange or subscription price or
           rate.

     Where (i) such issue comprises securities which by their terms of issues carry rights of
     conversion into, or exchange or subscription for, more than one class of Ordinary Shares and
     (ii) any such class of Ordinary Shares is the H Shares class, the date of issue of the securities
     which by their terms of issues carry rights of conversion into, or exchange or subscription for,
     H Shares shall be deemed to be the date of issue of all such securities for the purpose of these
     Conditions.

     Such adjustment shall become effective on the date of issue of such securities (or, if later, the
     first date on which the fraction above is capable of being determined in accordance with these
     Conditions).

5.2.8 Modification of Rights of Conversion etc.: If and whenever there shall be any modification of
      the rights of conversion, exchange, subscription, purchase or acquisition attaching to any such
      securities (other than the Bonds) as are mentioned in Condition 5.3.7 (other than in accordance
      with the terms of such securities) so that the consideration per Ordinary Share of one or more
      classes (for the number of Ordinary Shares of such classes available on conversion, exchange,
      subscription, purchase or acquisition following the modification) is reduced and, in each case,
      is less than 95 per cent. of the Current Market Price per H Share on the date of announcement
      of the proposals for such modifications (for the purpose of this Condition 5.3.8, the
      “Determination Date”), the Conversion Price shall be adjusted by multiplying the Conversion
      Price in force immediately before such modifications by the following fraction:

                                               A + B1 + B2
                                               A + C1 + C2

     Where:

     A     is the aggregate number of Ordinary Shares of all classes in issue immediately before the
           Determination Date;

     B1    is the number of Ordinary Shares of one class which the aggregate consideration receivable
           by the Issuer for the Ordinary Shares of such class to be issued on conversion or exchange
           or on exercise of the right of subscription, purchase or acquisition attached to the securities
           so modified would purchase at such Current Market Price or, if lower, the existing
           conversion, exchange subscription, purchase or acquisition price of such securities;


                                                83
     B2    where applicable, is the number of Ordinary Shares of a second class which the aggregate
           consideration receivable by the Issuer for the Ordinary Shares of such class to be issued
           on conversion or exchange or on exercise of the right of subscription, purchase or
           acquisition attached to the securities so modified would purchase at such Current Market
           Price or, if lower, the existing conversion, exchange subscription, purchase or acquisition
           price of such securities;

     C1    is the maximum number of Ordinary Shares of one class to be issued on conversion or
           exchange of such securities or on the exercise of such rights of subscription, purchase or
           acquisition attached thereto at the modified conversion, exchange, subscription, purchase
           or acquisition price or rate but giving credit in such manner as an Independent Financial
           Advisor (or, if the Calculation Agent determines in its sole discretion it is capable of
           making such determination in its capacity as Calculation Agent, the Calculation Agent)
           considers appropriate (if at all) for any previous adjustment under this Condition 5.3.8 or
           Condition 5.3.7; and

     C2    where applicable, is the maximum number of Ordinary Shares of a second class to be
           issued on conversion or exchange of such securities or on the exercise of such rights of
           subscription, purchase or acquisition attached thereto at the modified conversion,
           exchange, subscription, purchase or acquisition price or rate but giving credit in such
           manner as an Independent Financial Advisor (or, if the Calculation Agent determines in its
           sole discretion it is capable of making such determination in its capacity as Calculation
           Agent, the Calculation Agent) considers appropriate (if at all) for any previous adjustment
           under this Condition 5.3.8 or Condition 5.3.7.

     Where (i) such modification is in respect of securities which by their terms of issues carry rights
     of conversion into, or exchange or subscription for, more than one class of Ordinary Shares and
     (ii) any such class of Ordinary Shares is the H Shares class, the date of modification of rights
     of conversion into, or exchange or subscription for H Shares shall be deemed to be the date of
     modification of all rights of conversion into, or exchange or subscription for Ordinary Shares for
     the purpose of these Conditions.

     Such adjustment shall become effective on the date of modification of the rights of conversion,
     exchange, subscription, purchase or acquisition attaching to such securities (or, if later, the first
     date on which the fraction above is capable of being determined in accordance with these
     Conditions).

5.2.9 Other Offers to Ordinary Shareholders: In respect of each class of Ordinary Shares, if and
      whenever the Issuer or any of its Subsidiaries or (at the direction or request of or pursuant to
      any arrangements with the Issuer or any of its Subsidiaries) any other company, person or entity
      issues, sells or distributes any securities in connection with an offer pursuant to which the
      Ordinary Shareholders of such class generally are entitled to participate in arrangements
      whereby such securities may be acquired by them (except where the Conversion Price falls to
      be adjusted under Condition 5.3.4, Condition 5.3.5, Condition 5.3.6 or Condition 5.3.7 (or,
      where applicable, would fall to be so adjusted if the relevant issue or grant was at less than 95
      per cent. of the Current Market Price per H Share on the relevant Determination Date)), the
      Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately
      before such issue by the following fraction:

                                                  A – B
                                                    A

     Where:

     A     is the sum of the products of, in respect of each of the classes of Ordinary Shares in issue
           immediately prior to the Determination Date, (i) the number of Ordinary Shares of such
           class in issue and (ii) the Current Market Price per Ordinary Share of such class on the date
           on which the terms of such issue, sale or distribution of securities are first publicly
           announced (for the purpose of this Condition 5.3.9, the “Determination Date”); and

     B     is the aggregate Fair Market Value of the portion of the aggregate rights attributable to the
           Ordinary Shares in respect of each such class of Ordinary Shares.


                                                84
            Such adjustment shall become effective on the date of issue, sale or distribution of the securities
            or, if a record date is fixed therefor, immediately after such record date (or if later, the first date
            on which the fraction above is capable of being determined in accordance with these
            Conditions).

            For the purpose of the above, Fair Market Value shall (subject as provided in the definition of
            “Fair Market Value” (as defined in Condition 5.8)) be determined as at the Determination Date.

      5.2.10 Other Events: If the Issuer determines, in its sole discretion following consultation with the
             Calculation Agent, that an adjustment should be made to the Conversion Price as a result of one
             or more events or circumstances not referred to in this Condition 5.3, the Issuer shall, at its own
             expense, consult an Independent Financial Advisor to determine as soon as practicable what
             adjustment (if any) to the Conversion Price is fair and reasonable to take account thereof, if the
             adjustment would result in a reduction in the Conversion Price, and the date on which such
             adjustment should take effect and upon such determination by the Independent Financial Advisor
             such adjustment (if any) shall be made and shall take effect in accordance with such
             determination.

      5.2.11 Further Classes of Ordinary Shares: In the event that the Issuer has more than two classes of
             Ordinary Shares outstanding at any time, the formulae set out in this Condition 5.3 shall be
             restated to take into account such further classes of Ordinary Shares so that “B1 + B 2” and “C 1 +
             C 2” shall become “B1 + B 2 + B 3” and “C 1 + C 2 + C 3” and “B 3” and “C 3” shall have the same
             meaning as “B1” and “C1”, respectively, but by reference to a third class of Ordinary Shares and
             so on.

      5.2.12 Modifications: Where the events or circumstances giving rise to any adjustment pursuant to this
             Condition 5.3 have already resulted or will result in an adjustment to the Conversion Price or
             where the events or circumstances giving rise to any adjustment arise by virtue of events or
             circumstances which have already given rise or will give rise to an adjustment to the Conversion
             Price, such modification (if any) shall be made to the operation of the provisions of this
             Condition 5.3 as may be advised by the Independent Financial Advisor to be in its opinion
             appropriate to give the intended result.

5.3   Undertakings

      5.3.1 The Issuer has undertaken in the Trust Deed, inter alia, that so long as any Bond remains
            outstanding, save with the approval of an Extraordinary Resolution (as defined in the Trust
            Deed) of the Bondholders:

            (i)    it will use its all reasonable endeavors (a) to maintain a listing for the H Shares on the
                   Hong Kong Stock Exchange, (b) to obtain and maintain a listing for all the H Shares issued
                   on the exercise of the Conversion Rights attaching to the Bonds on the Hong Kong Stock
                   Exchange and (c) if the Issuer is unable to obtain or maintain such listing, to obtain and
                   maintain a listing for all the issued H Shares on such Alternative Stock Exchange as the
                   Issuer may from time to time determine, and will forthwith give notice to the Bondholders
                   in accordance with Condition 16 of the listing or delisting of the H Shares (as a class) by
                   any such stock exchange;

            (ii)   it will pay the expenses of the issue and delivery of, and all expenses of obtaining listing
                   for, H Shares arising on conversion of the Bonds (save for the Duties to be borne by any
                   Bondholder as described in Condition 5.2.2);




                                                         85
           (iii) it will not make any reduction of its registered share capital or any uncalled liability in
                 respect thereof or of any share premium account or capital redemption reserve fund
                 (except, in each case, as permitted by law (including but not limited to repurchase or
                 cancellation of its shares (i) pursuant to any share incentive or share option schemes of the
                 Issuer; (ii) as a result of its shareholders’ dissent to the Issuer’s merger or segregation in
                 a shareholders’ meeting and request the Issuer to repurchase its shares; (iii) for the
                 protection of the interests of the Issuer’s shareholders; and (iv) as permitted by laws and
                 regulations and the Issuer’s articles of association) provided that the reduction results in
                 an adjustment to the Conversion Price then in effect); and

           (iv) it will use all reasonable endeavors to maintain the listing of the Bonds on the Hong Kong
                Stock Exchange, and if the Issuer is unable to maintain such listing or such listing is
                unduly onerous, to use all reasonable endeavours to obtain and maintain a listing on
                another internationally recognised stock exchange as the Issuer may from time to time
                determine (with prior notification to the Trustee) and will forthwith give notice to the
                Bondholders in accordance with Condition 16 of the listing or delisting of the Bonds by
                any such stock exchange.

      5.3.2 In the Trust Deed, the Issuer has undertaken with the Trustee that so long as any Bond remains
            outstanding, save with the approval of an Extraordinary Resolution of the Bondholders:

           (i)    it will issue H Shares to Bondholders on exercise of Conversion Rights and ensure that at
                  all times it has the ability to issue free from pre-emptive or other similar rights such
                  number of H Shares as would enable the Conversion Rights and all other rights of
                  subscription and exchange for and conversion into H Shares to be satisfied in full and will
                  ensure that all H Shares delivered upon conversion of the Bonds will be duly and validly
                  issued as fully-paid and not subject to call for further funds, unless the Issuer has elected
                  to exercise the Cash Settlement Option in respect of any conversion of the Bonds; and

           (ii)   it will not make any offer, issue or distribution or take any action the effect of which would
                  be to reduce the Conversion Price below the par value of the H Shares of the Issuer
                  provided always that the Issuer shall not be prohibited from purchasing its H Shares to the
                  extent permitted by law.

      5.3.3 The Issuer has also given certain other undertakings in the Trust Deed for the protection of the
            Conversion Rights.

5.4   Notice of Change in Conversion Price

      The Issuer shall give notice to the Hong Kong Stock Exchange, to the Trustee and each Conversion
      Agent in writing and to the Bondholders in accordance with Condition 16 of any change in the
      Conversion Price. Any such notice relating to a change in the Conversion Price shall set forth the event
      giving rise to the adjustment, the Conversion Price prior to such adjustment, the adjusted Conversion
      Price and the effective date of such adjustment.




                                                       86
5.5   Change of Control Conversion Price

      If a Change of Control (as defined in Condition 7.5.5) shall have occurred, the Issuer shall give notice
      of that fact to the Bondholders pursuant to Condition 7.5.4 (the “Change of Control Notice”).

      Following the giving of a Change of Control Notice, upon any exercise of Conversion Rights such that
      the relevant Conversion Date falls within the period of 30 days following the later of (i) the relevant
      Change of Control and (ii) the date on which the Change of Control Notice is given to Bondholders
      (such period, the “Change of Control Conversion Period”), the Conversion Price (the “Change of
      Control Conversion Price”) applicable solely for the purpose of such exercise of Conversion Rights,
      shall be the Conversion Price in effect on the Conversion Date adjusted in accordance with the
      following formula:

                                      NCP = OCP/(1 + (CP × c/t))

      Where:

      NCP        =      the Change of Control Conversion Price;

      OCP        =      the Conversion Price in effect on the relevant Conversion Date;

      CP         =      47.5 per cent. expressed as a fraction;

      c          =      the number of days from and including the date on which the Change of Control
                        has occurred; and

      t          =      the number of days from and including the Issue Date to but excluding the
                        Maturity Date,


      provided that if the Change of Control Conversion Price determined pursuant to this Condition 5.6
      would (but for the operation of this proviso) otherwise be below the level permitted by applicable laws
      and regulations from time to time (if any), it shall instead be equal to such level as aforesaid.

      If the last day of a Change of Control Conversion Period shall fall during a Restricted Transfer Period
      or a Restricted Conversion Period, as the case may be, the Change of Control Conversion Period shall
      be extended such that its last day will be the fifteenth day following the last day of the Restricted
      Transfer Period or the Restricted Conversion Period, as the case may be.

5.6   Provisions Relating to Changes in Conversion Price

      5.6.1 Minor Adjustments: On any adjustment, the resultant Conversion Price, if not an integral
            multiple of one Hong Kong cent, shall be rounded down to the nearest one Hong Kong cent. No
            adjustment shall be made to the Conversion Price if such adjustment (rounded down if
            applicable) would be less than one per cent. of the Conversion Price then in effect. Any
            adjustment not required to be made, and/or any amount by which the Conversion Price has been
            rounded down, shall be carried forward and taken into account in any subsequent adjustment,
            and such subsequent adjustment shall be made on the basis that the adjustment not required to
            be made had been made at the relevant time and/or, as the case may be, that the relevant rounding
            down had not been made. Notice of any adjustment shall be given by the Issuer to the
            Bondholders in accordance with Condition 16 and to the Trustee and the Agents in writing, in
            each case promptly after the determination thereof.




                                                     87
5.6.2 Decision and Determination of the Calculation Agent or an Independent Financial Advisor:

     (a)   Adjustments to the Conversion Price shall be determined and calculated by the Calculation
           Agent upon request from the Issuer and/or, to the extent so specified in the Conditions and
           upon request from the Issuer, by an Independent Advisor.

           Adjustments to the Conversion Price calculated by the Calculation Agent or, where
           applicable, an Independent Advisor and any other determinations made by the Calculation
           Agent or, where applicable, an Independent Advisor, or an opinion of an Independent
           Advisor, pursuant to these Conditions shall in each case be made in good faith and shall
           be final and binding (in the absence of manifest error) on the Issuer, the Trustee, the
           Bondholders, the Calculation Agent (in the case of a determination by an Independent
           Advisor) and the Agents.

     (b)   Subject as provided in the Calculation Agency Agreement, the Calculation Agent may
           consult, at the expense of the Issuer, on any matter (including, but not limited to, any legal
           matter), any legal or other professional adviser and it shall be able to rely upon, and it shall
           not be liable and shall incur no liability as against the Trustee, the Bondholders or the
           Agents in respect of anything done, or omitted to be done, relating to that matter in good
           faith in accordance with that adviser’s opinion.

     (c)   The Calculation Agent shall act solely upon the request from, and exclusively as agent of,
           the Issuer and in accordance with these Conditions. Neither the Calculation Agent (acting
           in such capacity) nor any Independent Advisor appointed in connection with the Bonds
           (acting in such capacity) will thereby assume any obligations towards or relationship of
           agency or trust and shall not be liable and shall incur no liability in respect of anything
           done, or omitted to be done in good faith, in its capacity as Calculation Agent as against
           the Trustee, the Bondholders or the Agents.

     (d)   If, following consultation between the Issuer and the Calculation Agent, any doubt shall
           arise as to an adjustment to the Conversion Price under Condition 5.3 or Condition 5.6, a
           written opinion of such Independent Financial Advisor in respect thereof shall be
           conclusive and binding on the Issuer, the Calculation Agent, the Bondholders and the
           Trustee, save in the case of manifest error.

5.6.3 Minimum Conversion Price: Notwithstanding the provisions of this Condition 5, the Issuer
      undertakes that: (i) the Conversion Price shall not in any event be reduced to below the nominal
      or par value of the H Shares as a result of any adjustment hereunder unless under applicable law
      then in effect the Bonds may be converted at such reduced Conversion Price into legally issued,
      fully paid and non-assessable H Shares; and (ii) it shall not take any action, and shall procure
      that no action is taken, that would otherwise result in an adjustment to the Conversion Price to
      below such nominal or par value or any minimum level permitted by applicable laws or
      regulations.

5.6.4 Multiple Events: Where more than one event which gives or may give rise to an adjustment to
      the Conversion Price occurs within such a short period of time that, in the opinion of an
      Independent Financial Advisor, the foregoing provisions would need to be operated subject to
      some modification in order to give the intended result, such modification shall be made to the
      operation of the foregoing provisions as may be advised by such Independent Financial Advisor
      to be in its opinion appropriate in order to give such intended result.

5.6.5 Upward/Downward Adjustment: No adjustment involving an increase in the Conversion Price
      will be made, except in the case of a consolidation, subdivision or re-classification of the
      H Shares as referred to in Condition 5.3.1 The Issuer may at any time and for a specified period
      of time only, following notice being given to the Trustee in writing and to the Bondholders in
      accordance with Condition 16, reduce the Conversion Price, subject to Condition 5.7.3.


                                                88
5.6.6 Trustee Not Obliged to Monitor or Make Calculations: Neither the Trustee nor any Agent shall
      be under any duty to monitor whether any event or circumstance has happened or exists which
      may require an adjustment to be made to the Conversion Price or to make any calculation or
      determination (or verification thereof) in connection with the Conversion Price and none of them
      will be responsible or liable to Bondholders or any other person for any loss arising from any
      failure by it to do so or for any delay by the Issuer or any Independent Financial Advisor in
      making any calculation or determination or any erroneous calculation or determination in
      connection with the Conversion Price.

5.6.7 Employee Share Option Schemes: No adjustment will be made to the Conversion Price when
      Ordinary Shares or other securities (including rights or options) are issued, offered, exercised,
      allotted, appropriated, modified or granted to, or for the benefit of, employees (including
      directors) of the Issuer or any of its Subsidiaries pursuant to any employee share scheme or plan
      (and which employee share scheme or plan is in compliance with, if applicable, the Rules
      Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited or, if
      applicable, the Stock Listing Rules of the Shenzhen Stock Exchange or, if relevant, the listing
      rules of the Alternative Stock Exchange) (“Share Scheme Options”) unless any such issue or
      grant of Share Scheme Options (which, but for this provision, would have required adjustment
      pursuant to Condition 5) would result in the total number of Ordinary Shares which may be
      issued upon exercise of all Share Scheme Options granted during the 12-month period up to and
      including the date of such issue or grant representing, in aggregate, more than 2 per cent. of the
      average of the issued and outstanding Ordinary Shares during such 12-month period. For the
      avoidance of doubt, any Ordinary Shares issued in excess thereof, and only such Ordinary Shares
      issued in excess thereof, shall be subject to adjustment to the Conversion Price and taken into
      account in determining such adjustment as set out in Condition 5.3.

5.6.8 Consideration Receivable: For the purpose of any calculation of the consideration receivable or
      price pursuant to Condition 5.3.4, Condition 5.3.6, Condition 5.3.7 and Condition 5.3.8, the
      following provisions shall apply:

     (i)    the aggregate consideration receivable or price for Ordinary Shares of a class issued for
            cash shall be the amount of such cash;

     (ii)   (a) the aggregate consideration receivable for Ordinary Shares of a class to be issued on
            the conversion, exercise or exchange of any options, warrants or other rights or securities
            (or following any modification thereof) shall be deemed to be the consideration received
            or receivable by the Issuer for any such options, warrants or other rights or securities (or
            following any modification thereof); (b) the aggregate consideration receivable for
            Ordinary Shares of a class to be issued on the exercise of rights of subscription attached
            to any such securities (or following any modification thereof) shall be deemed to be that
            part (which may be the whole) of the consideration received or receivable by the Issuer for
            such securities (or following any modification thereof) which is attributed by the Issuer to
            such rights of subscription or, if no part of such consideration is so attributed, to the Fair
            Market Value of such rights of subscription as at the relevant Determination Date, plus in
            the case of each of (a) and (b) above, the additional minimum consideration (if any) to be
            received by the Issuer on the conversion, exercise or exchange of such options, warrants
            or other rights or securities (or following any modification thereof), or on the exercise of
            such rights of subscription; and (c) the consideration per Ordinary Share of a class
            receivable by the Issuer on the conversion, exercise or exchange of, or on the exercise of
            such rights of subscription attached to, such options, warrants or other rights or securities
            (or following any modification thereof) shall be the aggregate consideration referred to in
            (a) or (b) above (as the case may be) divided by the number of Ordinary Shares of such
            class to be issued on such conversion or exchange or exercise at the initial conversion,
            exchange or subscription price or rate;

     (iii) if the consideration or price determined pursuant to (i) or (ii) above of this Condition 5.7.8
           (or any component thereof) shall be expressed in a currency other than HK dollars, it shall
           be converted into HK dollars at the Prevailing Rate on the relevant Determination Date;


                                                 89
            (iv) in determining the consideration or price pursuant to the above, no deduction shall be made
                 for any commissions or fees (howsoever described) or any expenses paid or incurred for
                 any underwriting, placing or management of the issue of the relevant Ordinary Shares of
                 a class or securities or options, warrants or rights, or otherwise in connection therewith;

            (v)   the consideration or price shall be determined as provided above on the basis of the
                  consideration or price received, receivable, paid or payable, regardless of whether all or
                  part thereof is received, receivable, paid or payable by or to the Issuer or another entity;
                  and

            (vi) if as part of the same transaction, Ordinary Shares of a class shall be issued or issuable for
                 a consideration receivable in more than one or in different currencies then the
                 consideration receivable per Share shall be determined by dividing the aggregate
                 consideration (determined as aforesaid and converted if and to the extent not in HK dollars,
                 into HK dollars as aforesaid) by the aggregate number of Ordinary Shares so issued.

5.7   Definitions

      For the purposes of these Conditions:

      “Alternative Stock Exchange” means, at any time, in the case of the H Shares, if they are not at that
      time listed and traded on the Hong Kong Stock Exchange, the principal stock exchange or securities
      market on which such H Shares are then listed or quoted or dealt in;

      “Applicable Date” means, in the case of an adjustment to the Conversion Price pursuant to:

      (a)   Condition 5.3.1, the date on which the relevant consolidation, subdivision or re-classification
            takes effect;

      (b)   Condition 5.3.2, 5.3.3, 5.3.4, 5.3.5 or 5.3.9 in respect of any issue, distribution, grant or offer
            in respect of one or more classes of Ordinary Shares (including H Shares), (I) the relevant
            Ex-Date in respect thereof, if no such date is capable of being determined in accordance with
            (I), such other date as is determined to be appropriate by an Independent Financial Advisor;

      (c)   Condition 5.3.2, 5.3.3, 5.3.4, 5.3.5 or 5.3.9 in respect of any issue, distribution, grant or offer
            in respect of any class of Ordinary Shares (other than H Shares), the date of first public
            announcement of the terms thereof; or

      (d)   Condition 5.3.6, 5.3.7 or 5.3.8, the relevant Determination Date as is mentioned in Condition
            5.3.6, 5.3.7 or 5.3.8, as the case may be.

      “Applicable RA Date” means, in the case of an adjustment to the Conversion Price pursuant to:

      (e)   Condition 5.3.1, the record date or other due date for the establishment of entitlement in respect
            of the relevant consolidation, subdivision or re-classification;

      (f)   Condition 5.3.2, 5.3.3, 5.3.4, 5.3.5 or 5.3.9 in respect of any issue, distribution, grant or offer
            in respect of one or more classes of Ordinary Shares (including H Shares), (I) the record date
            or other due date for the establishment of entitlement in respect thereof or (II) if no such date
            is capable of being determined in accordance with (I), the date of first public announcement of
            such issue, distribution, grant or offer;

      (g)   Condition 5.3.2, 5.3.3, 5.3.4, 5.3.5 or 5.3.9 in respect of any issue, distribution, grant or offer
            in respect of one or more classes of Ordinary Shares (other than H Shares), the date of first
            public announcement of such issue, distribution, grant or offer; or

      (h)   Condition 5.3.6, 5.3.7 or 5.3.8, the relevant Determination Date as is mentioned in Condition
            5.3.6, 5.3.7 or 5.3.8, as the case may be.


                                                      90
“Cash Settlement Calculation Period” means the period of 20 consecutive H Share Stock Exchange
Business Days commencing on the second H Share Stock Exchange Business Day following the Cash
Settlement Notice Date.

“Closing Price” means, in respect of an Ordinary Share of any class or any other asset, option,
warrant or other right or other security, on any day, the official closing market price on the Relevant
Stock Exchange in respect thereof published by or derived from Bloomberg page HP (or any successor
ticker page) (setting ‘Official Closing Price’, or any other successor setting) in respect of such
Ordinary Share, or other asset, option, warrant or other right or other security (all as determined by
the Calculation Agent) (and for the avoidance of doubt such Bloomberg page is, as at the Issue Date,
(i) for the H Shares, 3759 HK Equity HP and (ii) for the A Shares, 300759 CH Equity HP), if available
or, in any other case, such other source (if any) as shall be determined in good faith to be appropriate
by an Independent Financial Advisor on such day, provided that:

(a)    if on any such day (for the purpose of this definition, the “Original Date”) such price is not
       available or cannot otherwise be determined as provided above, the Closing Price of an Ordinary
       Share, or other asset, option, warrant or other right or other security, in respect of such day shall
       be the Closing Price, determined by the Calculation Agent as provided above, on the
       immediately preceding Trading Day in respect thereof on which the same can be so determined,
       provided however that if such immediately preceding Trading Day falls prior to the seventh day
       before the Original Date, the Closing Price shall be considered to be not capable of being
       determined pursuant to this proviso (a); and

(b)    if the Closing Price cannot be determined as aforesaid, the Closing Price shall be determined as
       at the Original Date by an Independent Financial Advisor in such manner as it shall determine
       to be appropriate;

“Current Market Price” means, in respect of an Ordinary Share of a class on a particular date, the
average of the daily Closing Price on each of the 10 consecutive Trading Days ending on and including
the Trading Day immediately preceding such date and (if necessary) translated into HK dollars at the
Prevailing Rate as at the relevant date; provided that, if at any time during such 10 Trading Day period
the Closing Price shall have been based on a price ex-dividend (or ex-any other entitlement) and
during some other part of that period the Closing Price shall have been based on a price cum-dividend
(or cum-any other entitlement), then:

(i)    if the Ordinary Shares of such class to be issued or transferred and delivered do not rank for the
       dividend (or entitlement) in question, the Closing Price on the dates on which the Ordinary
       Shares of such class shall have been based on a price cum-dividend (or cum-any other
       entitlement) shall for the purpose of this definition be deemed to be the amount thereof reduced
       by an amount equal to the Fair Market Value of any such dividend or entitlement per Ordinary
       Shares of such class; or

(ii)   if the Ordinary Shares of such class to be issued or transferred and delivered rank for the
       dividend or entitlement in question, the Closing Price on the dates on which the Ordinary Shares
       of such class shall have been based on a price ex-dividend (or ex-any other entitlement) shall
       for the purpose of this definition be deemed to be the amount thereof increased by the Fair
       Market Value of any such dividend or entitlement per Ordinary Shares of such class, and
       provided that, if on each of the said 10 Trading Days the Closing Price shall have been based
       on a price cum-dividend (or cum-any other entitlement) in respect of a dividend (or other
       entitlement) which has been declared or announced but the Ordinary Shares of such class to be
       issued or transferred and delivered do not rank for that dividend (or other entitlement), the
       Closing Price on each of such dates shall for the purposes of this definition be deemed to be the
       amount thereof reduced by an amount equal to the Fair Market Value of any such dividend or
       entitlement per Ordinary Shares of such class;


                                                  91
“Capital Distribution” means, on a per Ordinary Share basis, (i) any distribution of assets in specie
to the holders of such Ordinary Shares by the Issuer for any financial period whenever paid or made
and however described (and for these purposes a distribution of assets in specie includes, without
limitation, an issue of Ordinary Shares or other securities credited as fully or partly paid (other than
an issue of Ordinary Shares in the circumstances set out in Condition 5.3.1, or Condition 5.3.2(i)) by
way of capitalization of reserves, but excludes a Scrip Dividend adjusted for under Condition
5.3.2(ii)); and (ii) any cash dividend or distribution on a gross basis (including, without limitation, the
relevant cash amount of a Scrip Dividend) of any kind to the holders of such Ordinary Shares by the
Issuer for any financial period (whenever paid and however described), and shall include a purchase
or redemption of Ordinary Shares by or on behalf of the Issuer (except a purchase or redemption of
Ordinary Shares by or on behalf of the Issuer (or a purchase of Ordinary Shares by or on behalf of
a Subsidiary of the Issuer), where the weighted average price (before expenses) on any one day in
respect of such purchases does not exceed the Current Market Price of the Ordinary Shares by more
than five per cent. either (a) on that date, or (b) where an announcement has been made of the intention
to purchase Ordinary Shares at some future date at a specified price, on the Trading Day immediately
preceding the date of such announcement and, if in the case of either (a) or (b) of this definition, the
relevant day is not a Trading Day, the immediately preceding Trading Day) in an amount to be
determined by an Independent Financial Advisor;

“Cash Settlement Ratio” means, in respect of an exercise of Conversion Rights in respect of which
the Issuer has exercised the Cash Settlement Option, such number as is equal to (x) the Cash Settled
H Shares in respect of such exercise of Conversion Rights divided by (y) the Reference H Shares in
respect of such exercise of Conversion Rights.

“Ex-Date” means, in relation to any Capital Distribution, capitalisation, consolidation,
reclassification, redesignation or subdivision, issue, grant, offer or other entitlement, in each case in
respect of the H Shares, the first Trading Day for the H Shares on which the H Shares are traded ex-
the relevant Capital Distribution, capitalisation, consolidation, reclassification, redesignation or
subdivision, issue, grant, offer or other entitlement.

“Fair Market Value” means, with respect to any asset, security, option, warrant or other right on any
date (for the purpose of this definition, the “FMV Date”):

(a)   (other than where paragraph (b), (c) or (d) below applies) in the case of any asset, security,
      option, warrant or other right, the fair market value thereof on such FMV Date as determined by
      an Independent Financial Advisor on the basis of commonly accepted market valuation method
      and taking into account such factors as it considers appropriate;

(b)   in the case of any cash Capital Distribution, the amount of such cash Capital Distribution, as
      determined by the Calculation Agent,

(c)   in the case of any other cash amount, the amount of such cash, as determined by the Calculation
      Agent;

(d)   in the case of any assets, options, warrants or other rights or other securities (including any class
      of Ordinary Shares) that are or will upon issuance be publicly traded on a Relevant Stock
      Exchange of adequate liquidity (as determined by an Independent Financial Advisor (or, if the
      Calculation Agent determines in its sole discretion it is capable of making such determination
      in its capacity as Calculation Agent, the Calculation Agent)), the arithmetic mean of the daily
      Closing Prices of such assets, options, warrants or other rights or securities during the period of
      five Trading Days for such assets, options, warrants or other rights or securities commencing on
      such FMV Date (or, if later, the date (for the purpose of this definition, the “Adjusted FMV
      Date”) which falls on the first such Trading Day such assets, options, warrants or other rights
      or securities are publicly traded, provided that provided that where such Adjusted FMV Date
      falls after the seventh day following the FMV Date, the Fair Market Value of such assets,
      options, warrants or other rights or securities shall instead be determined pursuant to paragraph
      (a) above, and no such Adjusted FMV Date shall be deemed to apply),


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and provided that such amounts, if not expressed in HK dollars shall be translated into HK dollars at
the Prevailing Rate on such FMV Date (or, as the case may be, the Adjusted FMV Date), all as
determined by the Calculation Agent. In addition, in the case of paragraphs (b) and (c) above, the Fair
Market Value shall be determined by the Calculation Agent on a gross basis and disregarding any
withholding or deduction required to be made for or on account of tax and disregarding any associated
tax credit;

“Hong Kong Stock Exchange” means The Stock Exchange of Hong Kong Limited or any successor
thereto;

“H Share Stock Exchange Business Day” means any day (other than a Saturday or Sunday) on which
the Hong Kong Stock Exchange or the Alternative Stock Exchange (as the case may be) is open for
the business of dealing in securities;

“Independent Financial Advisor” means an independent investment bank or licensed financial
advisor or institution of international repute (acting as an expert) (which may include the Calculation
Agent) selected and appointed at its own cost by the Issuer and notified in writing to the Trustee. The
Trustee shall not be responsible for or under any obligation to appoint an Independent Financial
Advisor and shall have no responsibility or liability for verifying any calculation, determination,
certification, advice or opinion made, given or reached by it;

“Physically Settled H Shares” means, in respect of any exercise of Conversion Rights, (i) the
Reference H Shares or (ii) if the Cash Settlement Option has been exercised in respect of such exercise
of Conversion Rights, such number of H Shares (which may be equal to zero) as is equal to the
Reference H Shares minus the Cash Settled H Shares.

“Prevailing Rate” means, in respect of any currency on any day, the spot mid-rate of exchange
between the relevant currencies prevailing as at 12:00 noon (Hong Kong time) on that date as
appearing on or derived from the Relevant Page or, if such a rate cannot be determined at such time,
the rate prevailing as at 12:00 noon (Hong Kong time) on the immediately preceding day on which
such rate can be so determined, provided that in the case of any cash Capital Distribution in respect
of the H Shares, the “Prevailing Rate” shall be deemed to be the average benchmark exchange rate
between Renminbi and HK dollars, calculated in the manner as announced by the Issuer on the Hong
Kong Stock Exchange from time to time, being as at the Issue Date the average of the medium rate
of Renminbi to HK dollars as announced by the People’s Bank of China for five working days
preceding (and including) the date on which such cash Capital Distribution are declared at the relevant
annual general meeting;

“Reference Date” means, in respect of any Retroactive Adjustment, the date on which the relevant
adjustment to the Conversion Price becomes effective under Condition 5.3 (notwithstanding, as the
case may be, that the date upon which it becomes effective falls after the end of the Conversion
Period).

“Reference H Shares” means, in respect of any exercise of Conversion Rights, the number of
H Shares that would be deliverable by the Issuer in respect thereof in accordance with these
Conditions (assuming for this purpose no exercise of the Cash Settlement Option and disregarding any
Additional H Shares).

“Relevant Cash Dividend” means the aggregate cash dividend or distribution declared by the Issuer,
including any cash dividend in respect of which there is any Scrip Dividend;

“Relevant Page” means the relevant Bloomberg BFIX page (or its successor page) or, if there is no
such page, such other Bloomberg page (as determined by the Calculation Agent) displaying the
relevant information, or, if there is no such page, on the relevant Reuters HKDFIX page (or its
successor page) or such other information service provider (as determined to be appropriate by an
Independent Financial Advisor) that displays the relevant information;


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“Relevant Stock Exchange” means:

(a)   in respect of the H Shares, the Hong Kong Stock Exchange (or any successor thereto) or, if at
      the relevant time the H Shares are not at that time listed and admitted to trading on the Hong
      Kong Stock Exchange, the Alternative Stock Exchange (if any);

(b)   in respect of the A Shares, the Shenzhen Stock Exchange (or any successor thereto) or, if at the
      relevant time the A Shares are not at that time listed and admitted to trading on the Shenzhen
      Stock Exchange, the principal stock exchange or securities market (if any) on which such
      A Shares are then listed and traded; and

(c)   in respect of any assets, options, warrants or other rights or other securities (other than the
      H Shares or the A Shares), the principal stock exchange or securities market (if any) on which
      such assets, options, warrants or other rights or other securities are then listed and traded,

where “principal stock exchange or securities market” shall mean the stock exchange or securities
market on which the A Shares, or, as the case may be, such other assets, options, warrants or other
rights or other securities are listed and traded, provided that if the A Shares, or, as the case may be,
such other assets, options, warrants or other rights or other securities are listed and traded on more
than one stock exchange or securities market at the relevant time, then “principal stock exchange or
securities market” shall mean that stock exchange or securities market on which the A Shares, or, as
the case may be, such other assets, options, warrants or other rights or other securities are then listed
and traded as determined by the Calculation Agent (if the Calculation Agent determines that it is able
to make such determination) or (in any other case) by an Independent Financial Advisor by reference
to the stock exchange or securities market with the highest average daily trading volume in respect
of the A Shares, or, as the case may be, such other assets, options, warrants or other rights or other
securities.

“Scrip Dividend” means Ordinary Shares of any class issued in lieu of the whole or any part of any
Relevant Cash Dividend being a dividend which the Ordinary Shareholders concerned would or could
otherwise have received;

“Shenzhen Stock Exchange” means The Shenzhen Stock Exchange;

“Trading Day” means in respect of an Ordinary Share of any class, or other asset, option, warrant or
other right or other security, a day on which (i) the Relevant Stock Exchange in respect thereof is open
for dealing business and (ii) the Closing Price in respect thereof is capable of being determined
(disregarding for this purpose the provisos to the definition of “Closing Price”); and

“Volume Weighted Average Price” means, in respect of an Ordinary Share of any class or any other
asset, option, warrant or other right or other security, on any day, the volume weighted average price
on the Relevant Stock Exchange in respect thereof published by or derived from Bloomberg page HP
(or any successor ticker page) (setting ‘Weighted Average Line’, or any other successor setting) in
respect of such Ordinary Share, or other asset, option, warrant or other right or other security (all as
determined by the Calculation Agent) (and for the avoidance of doubt such Bloomberg page is, as at
the Issue Date, (i) for the H Shares, 3759 HK Equity HP and (ii) for the A Shares, 300759 CH Equity
HP), if available or, in any other case, such other source (if any) as shall be determined in good faith
to be appropriate by an Independent Financial Advisor on such day, provided that:

(a)   if on any such day (for the purpose of this definition, the “Original Date”) such price is not
      available or cannot otherwise be determined as provided above, the Volume Weighted Average
      Price of an Ordinary Share, or other asset, option, warrant or other right or other security, in
      respect of such day shall be the Volume Weighted Average Price, determined by the Calculation
      Agent as provided above, on the immediately preceding Trading Day in respect thereof on which
      the same can be so determined, provided however that if such immediately preceding Trading
      Day falls prior to the seventh day before the Original Date, the Volume Weighted Average Price
      shall be considered to be not capable of being determined pursuant to this proviso (a); and


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      (b)   if the Volume Weighted Average Price cannot be determined as aforesaid, the Volume Weighted
            Average Price shall be determined as at the Original Date by an Independent Financial Advisor
            in such manner as it shall determine to be appropriate.

      References to any issue or offer or grant to Ordinary Shareholders “as a class” or “by way of rights”
      shall be taken to be references to an issue or offer or grant to all or substantially all Ordinary
      Shareholders, other than Ordinary Shareholders by reason of the laws of any territory or requirements
      of any recognized regulatory body or any other stock exchange or securities market in any territory
      or in connection with fractional entitlements, it is determined not to make such issue or offer or grant.

6.    Payments

6.1   Principal

      Payment of principal, premium and interest (if any) will be made by transfer to the registered account
      of the Bondholder except in the case of any amount payable by the Issuer pursuant to Condition 5,
      where any amounts payable to a Bondholder will be made by U.S. dollar cheque drawn on a bank that
      processes payments in U.S. dollars and mailed to the address of the Bondholder or by transfer to a U.S.
      dollar account maintained by the payee, in either case in accordance with instructions given by the
      relevant Bondholder in the Conversion Notice. Such payment of principal will only be made after
      surrender of the relevant Certificate at the specified office of any of the Agents.

      If an amount which is due on the Bonds is not paid in full, the Registrar will annotate the Register
      with a record of the amount (if any) in fact paid.

      References in these Conditions, the Trust Deed and the Agency Agreement to principal in respect of
      any Bond shall, where the context so permits, be deemed to include a reference to any premium
      payable thereon.

      So long as the Bonds are represented by the Global Certificate and the Global Certificate is held on
      behalf of Euroclear or Clearstream (each, a “relevant clearing system”), each payment in respect of
      the Global Certificate will be made to the person shown as the holder thereof in the Register at the
      close of business (in the relevant clearing system) on the Clearing System Business Day before the due
      date for such payment, where “Clearing System Business Day” means a weekday (Monday to Friday,
      inclusive) except December 25 and January 1.

6.2   Registered Accounts

      For the purposes of this Condition 6, a Bondholder’s registered account means the U.S. dollar account
      maintained by or on behalf of it with a bank that processes payments in U.S. dollars, details of which
      appear on the Register at the close of business on the second Payment Business Day (as defined in
      Condition 6.6) before the due date for payment, and a Bondholder’s registered address means its
      address appearing on the Register at that time.

6.3   Fiscal Laws

      All payments are subject in all cases to (i) any applicable fiscal or other laws and regulations in the
      place of payment, but without prejudice to the provisions of Condition 8 and (ii) any withholding or
      deduction required pursuant to an agreement described in Section 147 1(b) of the U.S. Internal
      Revenue Code of 1986, as amended (the “Code”) or otherwise imposed pursuant to Sections 1471
      through 1474 of the Code, any regulations or agreements thereunder, any official interpretations
      thereof, or (without prejudice to the provisions of Condition 8) any law implementing an
      intergovernmental approach thereto. No commissions or expenses shall be charged to the Bondholders
      in respect of such payments.


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6.4   Payment Initiation

      Payment instructions (for value on the due date or, if that is not a Payment Business Day, for value
      on the first following day which is a Payment Business Day) will be initiated on the due date for
      payment (or, if it is not a Payment Business Day, the immediately following Payment Business Day)
      or, in the case of a payment of principal, if later, on the Payment Business Day on which the relevant
      Certificate is surrendered at the specified office of an Agent.

6.5   Delay in Payment

      Bondholders will not be entitled to any interest (if any) or other payment for any delay after the due
      date in receiving the amount due if the due date is not a Business Day or if the Bondholder is late in
      surrendering its Certificate (if required to do so).

6.6   Payment Business Day

      In this Condition 6, “Payment Business Day” means a day other than a Saturday or Sunday on which
      commercial banks and foreign exchange markets are open for business in New York City and the city
      in which the specified office of the Principal Agent is located and, in the case of the surrender of a
      Certificate, in the place where the Certificate is surrendered.

6.7   Appointment of Agents

      The initial Agents and their initial specified offices are listed below. The Issuer reserves the right at
      any time, with the prior written approval of the Trustee, to vary or terminate the appointment of any
      Agent and appoint additional or replacement Agents provided that the Issuer shall at all times maintain
      (i) a Principal Agent, (ii) a Registrar, (iii) a Transfer Agent, (iv) a Conversion Agent and (v) such other
      agents as may be required by the stock exchange on which the Bonds may be listed, in each case, as
      approved in writing by the Trustee. The Issuer reserves the right at any time, with the prior written
      approval of the Trustee, to vary or terminate the appointment of the Calculation Agent and appoint
      another Calculation Agent provided that the Issuer shall at all times maintain a Calculation Agent
      which shall be a financial institution of international repute or a financial adviser with appropriate
      expertise.

      Notice of any changes in any Agent, their specified offices or the Calculation Agent will promptly be
      given by the Issuer to the Bondholders in accordance with Condition 16.

7.    Redemption, Purchase and Cancellation

7.1   Maturity

      Unless previously redeemed, converted or purchased and cancelled as provided herein, the Issuer will
      redeem each Bond at 100 per cent. of its outstanding principal amount on June 18, 2026 (the
      “Maturity Date”). The Issuer may not redeem the Bonds at its option prior to that date except as
      provided in Condition 7.2 or Condition 7.3 below (but without prejudice to Condition 9).

7.2   Redemption at the Option of the Issuer

      7.2.1 The Issuer may, having given not less than 30 nor more than 60 days’ notice (an “Optional
            Redemption Notice”) to the Bondholders, the Trustee and the Principal Agent (which notice will
            be irrevocable), redeem all but not some only of the Bonds for the time being outstanding at their
            principal amount as at the relevant redemption date:

           (i)   at any time after June 18, 2024 but prior to the Maturity Date, provided that no such
                 redemption may be made unless the Closing Price of an H Share translated into U.S. dollars
                 at the Prevailing Rate applicable to each H Share Stock Exchange Business Day, for any


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                  20 H Share Stock Exchange Business Days within a period of 30 consecutive H Share
                  Stock Exchange Business Days, the last of such H Share Stock Exchange Business Day
                  shall occur not more than 10 days prior to the date upon which notice of such redemption
                  is given, was, for each such 20 H Share Stock Exchange Business Days, at least 130 per
                  cent. of the Conversion Price then in effect on each such H Share Stock Exchange Business
                  Day (converted into U.S. dollars at the Fixed Exchange Rate), the Conversion Price during
                  any such 30 consecutive H Share Stock Exchange Business Day period, appropriate
                  adjustments for the relevant days approved by an Independent Financial Advisor shall be
                  made for the purpose of calculating the Closing Price of the H Shares for such days;

           (ii)   if at any time the aggregate principal amount of the Bonds outstanding is less than 10 per
                  cent. of the aggregate principal amount originally issued (including any Bonds issued
                  pursuant to Condition 15).

           Upon the expiry of the Optional Redemption Notice, the Issuer will be bound to redeem the
           relevant Bonds for the time being outstanding at their principal amount as at the date fixed for
           such redemption.

      7.2.2 The Trustee and the Agents shall have no obligation to confirm whether the circumstances giving
            rise to a right for the Issuer to redeem under this Condition 7.2 have in any case arisen.

7.3   Redemption for Taxation Reasons

      7.3.1 At any time the Issuer may, having given not less than 30 nor more than 60 days’ notice to the
            Trustee, the Principal Agent and the Bondholders (which notice shall be irrevocable) redeem all
            but not some only of the Bonds at their principal amount as at the relevant redemption date (the
            “Tax Redemption Date”), if the Issuer satisfies the Trustee immediately prior to the giving of
            such notice that (i) the Issuer has or will become obliged to pay Additional Tax Amounts as
            provided or referred to in Condition 8 as a result of any change in, or amendment to, the laws
            or regulations of the PRC or Hong Kong or, in each case, any political subdivision or any
            authority thereof or therein having power to tax, or any change in the general application or
            official interpretation of such laws or regulations, which change or amendment becomes
            effective on or after June 8, 2021, and (ii) such obligation cannot be avoided by the Issuer taking
            reasonable measures available to it, provided that no such notice of redemption shall be given
            earlier than 90 days prior to the earliest date on which the Issuer would be obliged to pay such
            Additional Tax Amounts were a payment in respect of the Bonds then due. Prior to the
            publication of any notice of redemption pursuant to this Condition 7.3.1, the Issuer shall deliver
            to the Trustee (a) a certificate signed by two directors of the Issuer, each of whom are also
            Authorised Signatories of the Issuer, stating that the obligation referred to in (i) above of this
            Condition 7.3.1 cannot be avoided by the Issuer having taken reasonable measures available to
            it and (b) an opinion of independent legal or tax advisors of recognized standing to the effect
            that such change or amendment has occurred (irrespective of whether such amendment or change
            is then effective), and the Trustee shall be entitled to accept such certificate and opinion as
            sufficient evidence thereof, in which event the same shall be conclusive and binding on the
            Bondholders.

      7.3.2 If the Issuer gives a notice of redemption pursuant to this Condition 7.3, each Bondholder will
            have the right to elect that his Bond(s) shall not be redeemed and that the provisions of
            Condition 8 shall not apply in respect of any payment of principal, or interest (if any) to be made
            in respect of such Bond(s) which falls due after the relevant Tax Redemption Date whereupon
            no Additional Tax Amounts shall be payable in respect thereof pursuant to Condition 8 and
            payment of all amounts shall be made subject to the deduction or withholding of the taxation
            required to be withheld or deducted by the government of the PRC or Hong Kong or, in each
            case, any authority thereof or therein having power to tax. For the avoidance of doubt, any
            Additional Tax Amounts which had been payable in respect of the Bonds as a result of the laws
            or regulations of the government of the PRC or Hong Kong or, in each case, any authority


                                                      97
           thereof or therein having power to tax prior to June 8, 2021, will continue to be payable to such
           Bondholders. To exercise such right, the holder of the relevant Bond must complete, sign and
           deposit at the specified office of any Paying Agent during normal business hours (being between
           9.00 a.m. and 3.00 p.m.) a duly completed and signed notice of election, in the form for the time
           being current, obtainable from the specified office of any Paying Agent, together with the
           Certificate evidencing the Bonds on or before the day falling 10 days prior to the Tax
           Redemption Date. Such notice of election, once delivered, shall be irrevocable and may not be
           withdrawn without the Issuer’s consent.

7.4   Redemption at the Option of the Bondholders

      The holder of each Bond will have the right at such holder’s option, to require the Issuer to redeem
      all or some only of that holder’s Bonds on June 18, 2024 (the “Put Option Date”) at 100 per cent.
      of their outstanding principal amount on the Put Option Date. To exercise such right, the holder of the
      relevant Bond must complete, sign and deposit at the specified office of any Paying Agent during
      normal business hours (being between 9.00 a.m. and 3.00 p.m.) a duly completed and signed notice
      (the “Put Option Notice”), substantially in the form scheduled to the Agency Agreement, obtainable
      from the specified office of any Paying Agent, together with the Certificate evidencing the Bonds to
      be redeemed not earlier than 60 days and not later than 30 days prior to the Put Option Date.

      A Put Option Notice, once delivered, shall be irrevocable (and may not be withdrawn unless the Issuer
      consents to such withdrawal) and the Issuer shall redeem the Bonds the subject of a Put Option Notice
      delivered as aforesaid on the Put Option Date.

7.5   Redemption for Relevant Events

      7.5.1 Following the occurrence of a Relevant Event (as defined in Condition 7.5.5), the holder of each
            Bond will have the right at such holder’s option, to require the Issuer to redeem all or some only
            such holder’s Bonds on the Relevant Event Put Date (as defined below) at their principal amount
            as at the Relevant Event Put Date. To exercise such right, the holder of the relevant Bond must
            complete, sign and deposit at the specified office of any Paying Agent during normal business
            hours (being between 9.00 a.m. and 3.00 p.m.) a duly completed and signed notice of
            redemption, substantially in the form scheduled to the Agency Agreement, obtainable from the
            specified office of any Paying Agent (a “Relevant Event Put Exercise Notice”) together with
            the Certificate evidencing the Bonds to be redeemed by not later than 30 days following a
            Relevant Event, or, if later, 30 days following the date upon which notice thereof is given to
            Bondholders by the Issuer in accordance with Condition 16. The “Relevant Event Put Date”
            shall be the fourteenth day after the expiry of such period of 30 days as referred to above in this
            Condition 7.5.1.

      7.5.2 A Relevant Event Put Exercise Notice, once delivered, shall be irrevocable and may not be
            withdrawn without the Issuer’s consent. The Issuer shall redeem the Bonds which form the
            subject of the Relevant Event Put Exercise Notices delivered as aforesaid (subject to delivery of
            the relevant Certificates) on the Relevant Event Put Date.

      7.5.3 None of the Trustee or the Agents shall be required to monitor or take any steps to ascertain
            whether a Relevant Event or any event which could lead to the occurrence of a Relevant Event
            has occurred and shall not be liable to Bondholders or any other person for not doing so.

      7.5.4 Not later than seven days after becoming aware of a Relevant Event, the Issuer shall procure that
            notice regarding the Relevant Event shall be delivered to Bondholders (in accordance with
            Condition 16) and to the Trustee and the Principal Agent in writing stating:

           (i)    the Relevant Event Put Date;

           (ii)   the date of such Relevant Event and, briefly, the events causing such Relevant Event;


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     (iii) the date by which the Relevant Event Put Exercise Notice must be given;

     (iv) the redemption amount and the method by which such amount will be paid;

     (v)   the names and addresses of all Paying Agents;

     (vi) briefly, the Conversion Right and the Conversion Price as at the last practicable date
          immediately prior to the date on which such notice is given (and, if the Relevant Event is
          a Change of Control, (i) the Change of Control Conversion Price, determined for the
          purpose of such notice, on the basis of such Conversion Price as at such last practicable
          date as aforesaid, and (ii) the Change of Control Conversion Period);

     (vii) the procedures that Bondholders must follow and the requirements that Bondholders must
           satisfy in order to exercise their rights under this Condition 7.5 or their Conversion Right;
           and

     (viii) that a Relevant Event Put Exercise Notice, once validly given, may not be withdrawn
            without the Issuer’s consent.

7.5.5 For the purposes of this Condition 7.5:

     “Affiliated Holders” means, with respect to any specified natural person, any company,
     partnership, trust, foundation or other entity or investment vehicle for which such specified
     natural person retains sole voting and dispositive power with respect to the Ordinary Shares, as
     applicable, held by such company, partnership, trust, foundation or other entity or investment
     vehicle, and the trustees, legal representatives, beneficiaries and/or beneficial owners, but solely
     in such capacity, of such company, partnership, trust, foundation or other entity or investment
     vehicle;

     a “Change of Control” occurs when:

     (a)   the Founding Individuals, collectively, together with any voting rights controlled directly
           or indirectly by the Founding Individuals, including through any voting proxy arrangement
           and/or acting-in-concert agreement, ceases to be the single largest holder of voting rights
           in the Issuer;

     (b)   other than Founding Individuals, any person or persons, acting together, acquires control
           of the Issuer if such person or persons does not or do not have, and would not be deemed
           to have, control of the Issuer on the Issue Date;

     (c)   the Issuer consolidates with or merges into or sells or transfers all or substantially all of
           the Issuer’s assets to any other person, unless the consolidation, merger, sale or transfer
           will not result in an event specified in (b) above with respect to the Issuer or the successor
           entity; or

     (d)   one or more other persons acquires the legal or beneficial ownership of all or substantially
           all of the Issuer’s registered share capital;

     “control” means the acquisition or control of more than 50 per cent. of the voting rights of the
     registered share capital of the Issuer or the right to appoint and/or remove all or the majority of
     the members of the Issuer’s board of directors or other governing body, whether obtained
     directly or indirectly, and whether obtained by ownership of share capital, the possession of
     voting rights, contract or otherwise;

     a “Delisting” occurs when the H Shares cease to be listed or admitted to trading on the Hong
     Kong Stock Exchange;


                                                99
           “Founding Individuals” means (a) Dr. LOU Boliang (          ), Mr. LOU Xiaoqiang (           )
           and Ms ZHENG Bei (       ) and (b) each of the respective Affiliated Holders referred to in this
           Condition 7.5.5;

           a “H Share Suspension in Trading” means the suspension in trading of the H Shares for a
           period of 20 consecutive H Share Stock Exchange Business Days;

           a “person” includes any individual, company, corporation, firm, partnership, joint venture,
           undertaking, association, organization, trust, state or agency of a state (in each case whether or
           not being a separate legal entity) but does not include the Issuer’s board of directors or any other
           governing board and does not include the Issuer’s wholly-owned direct or indirect Subsidiaries;

           a “Relevant Event” means the occurrence of either (a) a Change of Control in the Issuer; (b)
           a Delisting or (c) a H Share Suspension in Trading; and

           “voting rights” means the right generally to vote at general meetings of shareholders of the
           Issuer (irrespective of whether or not, at the time, stock of any other class or classes shall have,
           or might have, voting power by reason of the happening of any contingency).

7.6   Purchases

      The Issuer or any of its Subsidiaries may, subject to applicable laws and regulations, at any time and
      from time to time purchase Bonds at any price in the open market or otherwise. The Bonds so
      acquired, while held by or on behalf of the Issuer or any such Subsidiary, shall not entitle them to
      convert the Bonds in accordance with these Conditions nor shall such Bonds be deemed to be
      outstanding for the purposes of, among other things, calculating quorums at meetings of the
      Bondholders and exercising any voting rights with respect to such Bonds and Conditions 9 and 13.

7.7   Cancellation

      All Bonds which are repurchased, redeemed or converted or purchased by or on behalf of the Issuer
      or any of its Subsidiaries will forthwith be cancelled. Certificates in respect of all Bonds cancelled
      will be forwarded to or to the order of the Registrar and such Bonds may not be reissued or resold.

7.8   Redemption Notices

      All notices to Bondholders given by or on behalf of the Issuer pursuant to this Condition 7 will be
      irrevocable and will be given in accordance with Condition 16 specifying: (i) the Conversion Price as
      at the date of the relevant notice; (ii) the last day on which Conversion Rights may be exercised; (iii)
      the Closing Price of the H Shares as at the latest practicable date prior to the publication of the notice,
      (iv) the date fixed for redemption; (v) the manner in which redemption will be effected; and (vi) the
      aggregate principal amount of the Bonds outstanding as at the latest practicable date prior to the
      publication of the notice.

      If more than one notice of redemption is given (being a notice given by either the Issuer or a
      Bondholder pursuant to these Conditions), the first in time shall prevail.

      Neither the Trustee nor any of the Agents shall be responsible for calculating or verifying the
      calculations of any amount payable on redemption of the Bonds pursuant to this Condition 7 and none
      of them shall be liable to the Bondholders or any other person for not doing so.




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8.    Taxation

8.1   All payments made by or on behalf of the Issuer in respect of the Bonds will be made free from any
      restriction or condition and will be made without deduction or withholding for or on account of any
      present or future taxes, duties, assessments or governmental charges of whatever nature imposed,
      levied, collected, withheld or assessed by or on behalf of the PRC or Hong Kong or, in each case, any
      authority thereof or therein having power to tax, unless deduction or withholding of such taxes, duties,
      assessments or governmental charges is compelled by law. Where such withholding or deduction is
      made by the Issuer by or within the PRC up to and including the aggregate rate applicable on June 8,
      2021 (the “Applicable Rate”), the Issuer will increase the amounts paid by it to the extent required,
      so that the net amount received by Bondholders equals the amounts which would otherwise have been
      receivable by them had no such withholding or deduction been required. If the Issuer is required to
      make a deduction or withholding in respect of PRC tax in excess of the Applicable Rate, or any Hong
      Kong deduction or withholding is required, in such event the Issuer shall pay such additional amounts
      (“Additional Tax Amounts”) as will result in receipt by the Bondholders of such amounts as would
      have been received by them had no such withholding or deduction been required, except that no
      Additional Tax Amounts shall be payable in respect of any Bond:

      8.1.1 to a holder (or to a third party on behalf of a holder) who is subject to such taxes, duties,
            assessments or governmental charges in respect of such Bond by reason of his having some
            connection with the PRC or Hong Kong, as the case may be, otherwise than merely by holding
            the Bond or by the receipt of amounts in respect of the Bond or where the withholding or
            deduction could be avoided by the holder making a declaration of non-residence or other similar
            claim for exemption to the appropriate authority which such holder is legally capable and
            competent of making but fails to do so; or

      8.1.2 (in the case of a payment of principal) if the Certificate in respect of such Bond is surrendered
            more than 30 days after the Relevant Date except to the extent that the holder would have been
            entitled to such additional amount on surrendering the relevant Certificate for payment on the
            last day of such period of 30 days.

8.2   “Relevant Date” means whichever is the later of (i) the date on which such payment first becomes
      due and (ii) if the full amount payable has not been received by the Trustee or the Principal Agent on
      or prior to such due date, the date on which, the full amount having been so received, notice to that
      effect shall have been given to the Bondholders and payment made.

8.3   References in these Conditions to principal and interest (if any) shall be deemed also to refer to any
      additional amounts or premiums which may be payable under these Conditions or any undertaking or
      covenant given in addition thereto or in substitution therefor pursuant to the Trust Deed.

8.4   Neither the Trustee nor any Agent shall be responsible for paying any tax, duty, charges, withholding
      or other payment referred to in this Condition 8 or for determining whether such amounts are payable
      or the amount thereof, and none of them shall be responsible or liable for any failure by the Issuer,
      any Bondholder or any third party to pay such tax, duty, charges, withholding or other payment in any
      jurisdiction or to provide any notice or information to the Trustee or any Agent that would permit,
      enable or facilitate the payment of any principal, premium (if any), interest or other amount under or
      in respect of the Bonds without deduction or withholding for or on account of any tax, duty, charge,
      withholding or other payment imposed by or in any jurisdiction.




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9.    Events of Default

      The Trustee at its discretion may, and if so requested in writing by the holders of not less than 25 per
      cent. in principal amount of the Bonds then outstanding or if so directed by an Extraordinary
      Resolution shall (subject in any such case to being indemnified and/or secured and/or pre-funded to
      its satisfaction), give notice to the Issuer that the Bonds are, and they shall accordingly thereby
      become, immediately due and repayable at their principal amount (subject as provided below and
      without prejudice to the right of Bondholders to exercise the Conversion Right in respect of their
      Bonds in accordance with Condition 5) if any of the following events (each an “Event of Default”)
      has occurred:

9.1   the Issuer fails to pay the principal and premium (if any) on any of the Bonds when due; or

9.2   failure by the Issuer to deliver the H Shares or pay the Cash Settlement Amount in U.S. dollars in
      respect of such H Shares as and when such H Shares are required to be delivered or as and when such
      Cash Settlement Amount in U.S. dollars is required to be paid, as the case may be, following
      conversion of a Bond; or

9.3   the Issuer does not perform or comply with one or more of its other obligations in the Bonds or the
      Trust Deed which default is in the opinion of the Trustee incapable of remedy or, if capable of remedy
      in the opinion of the Trustee, is not remedied within 30 days after written notice of such default shall
      have been given to the Issuer by the Trustee; or

9.4   the Issuer or any Principal Subsidiary is (or is, or could be, deemed by law or a court to be) insolvent
      or bankrupt or unable to pay its debts, stops, suspends or threatens to stop or suspend payment of all
      or a material part of (or of a particular type of) its debts, proposes or makes any agreement for the
      deferral, rescheduling or other readjustment of all or a material part of (or of a particular type of) its
      debts, proposes or makes a general assignment or an arrangement or composition with or for the
      benefit of the relevant creditors in respect of any of such debts or a moratorium is agreed or declared
      in respect of or affecting all or any part of (or of a particular type of) the debts of the Issuer or any
      Principal Subsidiary; or

9.5   (i) any other present or future indebtedness of the Issuer or any of its Subsidiaries for or in respect
      of moneys borrowed or raised becomes (or becomes capable of being declared) due and payable prior
      to its stated maturity by reason of any actual or potential default, event of default or the like
      (howsoever described), or (ii) any such indebtedness is not paid when due or, as the case may be,
      within any applicable grace period, or (iii) the Issuer or any of its Subsidiaries fails to pay when due
      any amount payable by it under any present or future guarantee for, or indemnity in respect of, any
      present or future indebtedness in respect of moneys borrowed or raised, provided that the aggregate
      amount of the relevant indebtedness, guarantees and indemnities in respect of which one or more of
      the events mentioned above in this Condition 9.5 have occurred equals or exceeds U.S.$25,000,000
      or its equivalent in other currency or currencies (as determined on the basis of the middle spot rate
      for the relevant currency against the U.S. dollar as quoted by any leading bank on the day on which
      such indebtedness become due and payable or is not paid or any such amount become due and payable
      or is not paid under any such guarantee or indemnity); or

9.6   a distress, attachment, execution or other legal process is levied, enforced or sued out on or against
      any material part of the property, assets or revenues of the Issuer or any of its Principal Subsidiaries
      and is not discharged or stayed within 30 days; or

9.7   an order is made or an effective resolution passed for the winding-up or dissolution, judicial
      management or administration of the Issuer or any Principal Subsidiary, or the Issuer or any Principal
      Subsidiary ceases or threatens to cease to carry on all or any material part of its business or operations,
      except for the purpose of and followed by a reconstruction, amalgamation, reorganisation, merger or
      consolidation (i) on terms approved by an Extraordinary Resolution of the Bondholders, or (ii) in the
      case of a Principal Subsidiary, whereby the undertaking and assets of such Principal Subsidiary are
      transferred to or otherwise vested in the Issuer or another Principal Subsidiary; or


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9.8   any mortgage, charge, pledge, lien or other encumbrance, present or future, created or assumed by the
      Issuer or any of its Subsidiaries on any material part of their respective property, assets or revenues
      becomes enforceable and any step is taken to enforce it (including the taking of possession or the
      appointment of a receiver, manager or other similar person) and is not discharged within 30 days; or

9.9   it is or will become unlawful for the Issuer to perform or comply with any one or more of its
      obligations under any of the Bonds or the Trust Deed; or

9.10 any action, condition or thing (including the obtaining or effecting of any necessary consent, approval,
     authorisation, exemption, filing, license, order, recording or registration) at any time required to be
     taken, fulfilled or done by the Issuer in order (i) to enable the Issuer lawfully to enter into, exercise
     its rights and perform and comply with its obligations under the Bonds and the Trust Deed, (ii) to
     ensure that those obligations are legally binding and enforceable and (iii) to make the Bonds and the
     Trust Deed admissible in evidence in the courts of the PRC or Hong Kong is not taken, fulfilled or
     done; or

9.11 any step is taken by any person with a view to the seizure, compulsory acquisition, expropriation or
     nationalisation of all or any material part of the assets of the Issuer or any Principal Subsidiary; or

9.12 the Trust Deed or any of the Bonds ceases for any reason (or is claimed by the Issuer not) to be the
     legal and valid obligations of the Issuer, binding upon it in accordance with its terms (subject to
     equitable principles and insolvency laws affecting creditors’ rights generally); or

9.13 any event occurs which under the laws of any relevant jurisdiction has an analogous effect to any of
     the events referred to in any of Conditions 9.6 to 9.8 (both inclusive) or Condition 9.10 or Condition
     9.11.

      The Trustee and the Agents shall not be bound to take any steps to ascertain whether any Event of
      Default or any condition, event or act which with the giving of notice and/or the lapse of time and/or
      fulfillment of any other conditions and/or the making of any determination would constitute an Event
      of Default has happened and none of them shall be responsible or liable to Bondholders or any other
      person for not doing so.

9.14 For purposes of this Condition 9, “Principal Subsidiary” means any Subsidiary of the Issuer:

      (i)    whose total revenue (consolidated in the case of a Subsidiary which itself has Subsidiaries) as
             shown by its latest audited income statement is at least 5 percent of the consolidated total
             revenue as shown by the latest published audited income statement of the Issuer and its
             consolidated Subsidiaries; or

      (ii)   whose net profits (consolidated in the case of a Subsidiary which itself has Subsidiaries) as
             shown by its latest audited income statement is at least 5 percent of the consolidated gross profit
             as shown by the latest published audited consolidated income statement of the Issuer and its
             consolidated Subsidiaries, including for the avoidance of doubt, the Issuer and its consolidated
             Subsidiaries’ share of profits of Subsidiaries not consolidated and of jointly controlled entities
             and after adjustments for minority interests; or

      (iii) whose total assets (consolidated in the case of a Subsidiary which itself has Subsidiaries) as
            shown by its latest audited balance sheet are at least 5 percent of the consolidated net assets of
            the Issuer and its Subsidiaries as shown by the latest published audited consolidated balance
            sheet of the Issuer and its Subsidiaries, including the investment of the Issuer and its
            consolidated Subsidiaries in each Subsidiary whose accounts are not consolidated with the
            consolidated audited accounts of the Issuer and of associated companies and after adjustment for
            minority interests;


                                                      103
      (iv) to which is transferred the whole or substantially the whole of the assets of a Subsidiary which
           immediately prior to such transfer was a Principal Subsidiary, whereupon the Principal
           Subsidiary which so transfers its assets shall forthwith upon such transfer cease to be a Principal
           Subsidiary and the Subsidiary to which the assets are so transferred shall immediately become
           a Principal Subsidiary, provided that on or after the date on which the first published audited
           accounts (consolidated, if appropriate) of the Issuer prepared as of a date later than such transfer
           are issued, whether or not such transferor Subsidiary or transferee Subsidiary would continue to
           be a Principal Subsidiary shall be determined on the basis of such accounts by virtue of the
           provisions of (i), (ii) or (iii) above;

           provided that, in relation to paragraphs (i), (ii) and (iii) above of this definition:

           (a)   in the case of a corporation or other business entity becoming a Subsidiary after the end
                 of the financial period to which the latest consolidated audited accounts of the Issuer
                 relate, the reference to the then latest consolidated audited accounts of the Issuer and its
                 Subsidiaries for the purposes of the calculation above shall, until consolidated audited
                 accounts of the Issuer for the financial period in which the relevant corporation or other
                 business entity becomes a Subsidiary are published, be deemed to be a reference to the then
                 latest consolidated audited accounts of the Issuer and its Subsidiaries adjusted to
                 consolidate the latest audited accounts (consolidated in the case of a Subsidiary which
                 itself has Subsidiaries) of such Subsidiary in such accounts;

           (b)   if at any relevant time in relation to the Issuer or any Subsidiary which itself has
                 Subsidiaries, no consolidated accounts are prepared and audited, total revenue, gross profit
                 or net assets of the Issuer and/or any such Subsidiary shall be determined on the basis of
                 pro forma consolidated accounts prepared for this purpose by or on behalf of the Issuer;

           (c)   if at any relevant time in relation to any Subsidiary, no accounts are audited, its net assets
                 (consolidated, if appropriate) shall be determined on the basis of pro forma accounts
                 (consolidated, if appropriate) of the relevant Subsidiary prepared for this purpose by or on
                 behalf of the Issuer; and

           (d)   if the accounts of any Subsidiary (not being a Subsidiary referred to in proviso (i) above)
                 are not consolidated with those of the Issuer, then the determination of whether or not such
                 Subsidiary is a Principal Subsidiary shall be based on a pro forma consolidation of its
                 accounts (consolidated, if appropriate) with the consolidated accounts (determined on the
                 basis of the foregoing) of the Issuer;

                 A certificate signed by an Authorised Signatory of the Issuer stating that, in their opinion,
                 a Subsidiary is or is not, or was or was not, a Principal Subsidiary shall, in the absence of
                 manifest error, be conclusive and binding on all parties.

10.   Prescription

      Claims in respect of amounts due in respect of the Bonds will become prescribed unless made within
      10 years (in the case of principal) and five years (in the case of default interest, if any) from the
      Relevant Date in respect thereof.




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11.   Meetings of Bondholders, Modification and Waiver

11.1 Meetings

      The Trust Deed contains provisions for convening meetings of Bondholders to consider any matter
      affecting their interests, including the sanctioning by Extraordinary Resolution of a modification of
      the Bonds or the provisions of the Trust Deed. Such a meeting may be convened by the Issuer or the
      Trustee and shall be convened by the Trustee if requested in writing to do so by Bondholders holding
      not less than 10 per cent. in principal amount of the Bonds for the time being outstanding and if it is
      indemnified and/or secured and/or pre-funded to its satisfaction against all costs and expenses. The
      quorum at any such meeting for passing an Extraordinary Resolution will be two or more persons
      holding or representing over 50 per cent. in principal amount of the Bonds for the time being
      outstanding or, at any adjournment of such meeting, two or more persons being or representing
      Bondholders whatever the principal amount of the Bonds so held or represented unless the business
      of such meeting includes consideration of proposals, inter alia, (i) to modify the due date for any
      payment in respect of the Bonds, (ii) to reduce or cancel the amount of principal or Equivalent Amount
      in respect of the Bonds, (iii) to change the currency of payment of the Bonds, or (iv) to modify or
      cancel the Conversion Rights or the put options specified in Condition 7 or (v) to modify the
      provisions concerning the quorum required at any meeting of the Bondholders or the majority required
      to pass an Extraordinary Resolution, in which case the necessary quorum for passing an Extraordinary
      Resolution will be two or more persons holding or representing not less than 75 per cent., or at any
      adjourned such meeting not less than 25 per cent., in principal amount of the Bonds for the time being
      outstanding. An Extraordinary Resolution passed at any meeting of Bondholders will be binding on
      all Bondholders, whether or not they are present at the meeting. The Trust Deed provides that a written
      resolution signed by or on behalf of the holders of not less than 90 per cent. of the aggregate principal
      amount of Bonds outstanding shall be as valid and effective as a duly passed Extraordinary
      Resolution.

11.2 Modification and Waiver

      The Trustee may (but shall not be obliged to) agree, without the consent of the Bondholders, to (i) any
      modification (except as mentioned in Condition 11.1 above and the Trust Deed) to, or the waiver or
      authorisation of any breach or proposed breach of, the Bonds, the Agency Agreement or the Trust
      Deed which is not, in the opinion of the Trustee, materially prejudicial to the interests of the
      Bondholders or (ii) any modification to the Bonds, the Agency Agreement or the Trust Deed which,
      in the Trustee’s opinion, is of a formal, minor or technical nature or to correct a manifest error or to
      comply with mandatory provisions of law. Any such modification, waiver or authorisation will be
      binding on the Bondholders and, unless the Trustee agrees otherwise, any such modification, waiver
      or authorisation will be notified by the Issuer to the Bondholders as soon as practicable thereafter.

11.3 Interests of Bondholders

      In connection with the exercise of its functions, rights, powers and discretions (including but not
      limited to those in relation to any proposed modification, authorisation or, waiver) the Trustee shall
      have regard to the interests of the Bondholders as a class and shall not have regard to the consequences
      of such exercise for individual Bondholders and the Trustee shall not be entitled to require on behalf
      of any Bondholder, nor shall any Bondholder be entitled to claim, from the Issuer or the Trustee any
      indemnification or payment in respect of any tax consequences of any such exercise upon individual
      Bondholders except to the extent provided for in Condition 8 and/or any undertakings given in
      addition thereto or in substitution therefor pursuant to the Trust Deed.

12.   Replacement of Certificates

      If any Certificate is mutilated, defaced, destroyed, stolen or lost, it may be replaced at the specified
      office of the Registrar or any Transfer Agent, subject to all applicable laws and stock exchange
      requirements, upon payment by the claimant of such costs as may be incurred in connection therewith
      and on such terms as to evidence and such indemnity and/or security as the Issuer and/or such Agent
      may require. Mutilated or defaced Certificates must be surrendered before replacements will be
      issued.


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13.   Enforcement

      At any time when the Bonds become due and payable, the Trustee may, at its discretion and without
      further notice, take such steps and/or actions and/or institute such proceedings against the Issuer as
      it may think fit to enforce the terms of the Trust Deed and the Bonds, but it need not take any such
      steps and/or actions and/or institute any such proceedings unless (i) it shall have been so directed by
      an Extraordinary Resolution or shall have been so requested in writing by the holders of not less than
      25 per cent. in principal amount of the Bonds then outstanding and (ii) it shall have been indemnified
      and/or secured and/or pre-funded to its satisfaction. No Bondholder may proceed directly against the
      Issuer unless the Trustee, having become bound so to proceed, fails to do so within a reasonable period
      and such failure is continuing.

14.   Indemnification of the Trustee

      The Trust Deed contains provisions for the indemnification of the Trustee and for its relief from
      responsibility including without limitation from taking proceedings to enforce payment unless
      indemnified and/or secured and/or prefunded of its satisfaction. The Trustee is entitled to enter into
      business transactions with the Issuer and any entity related (directly or indirectly) to the Issuer without
      accounting for any profit.

      The Trustee may rely without liability to Bondholders on any report, confirmation or certificate from
      or any advice or opinion of any legal counsel, accountants, financial advisers, financial institution or
      any other expert, whether or not obtained by or addressed to it and whether their liability in relation
      thereto is limited (by its terms or by any engagement letter relating thereto entered into by the Trustee
      or any other person or in any other manner) by reference to a monetary cap, methodology or otherwise.
      The Trustee may accept and shall be entitled to rely on any such report, confirmation, certificate,
      advice or opinion, in which case such report, confirmation, certificate, advice or opinion shall be
      binding on the Issuer and the Bondholders.

      Whenever the Trustee is required or entitled by the terms of the Trust Deed or these Conditions to
      exercise any discretion or power, take any action, make any decision or give any direction, the Trustee
      is entitled, prior to exercising any such discretion or power, taking any such action, making any such
      decision or giving any such direction, to seek directions from the Bondholders by way of
      Extraordinary Resolution, and the Trustee shall not be responsible for any loss or liability incurred by
      the Issuer, the Bondholders or any other person as a result of any delay in it exercising such discretion
      or power, taking such action, making such decision or giving such direction as a result of seeking such
      direction from the Bondholders or in the event that no direction is given to the Trustee by the
      Bondholders.

      None of the Trustee or any of the Agents shall be responsible for the performance by the Issuer and
      any other person appointed by the Issuer in relation to the Bonds of the duties and obligations on their
      part expressed in respect of the same and, unless it has written notice from the Issuer to the contrary,
      the Trustee and each Agent shall assume that the same are being duly performed. None of the Trustee
      or any Agent shall be liable to any Bondholder or any other person for any action taken by the Trustee
      or such Agent in accordance with the instructions of the Bondholders. The Trustee shall be entitled
      to rely on any direction, request or resolution of Bondholders given by holders of the requisite
      principal amount of Bonds outstanding or passed at a meeting of Bondholders convened and held in
      accordance with the Trust Deed. Neither the Trustee nor any of the Agents shall be under any
      obligation to ascertain whether any Event of Default or Potential Event of Default has occurred or
      monitor compliance by the Issuer with the provisions of the Trust Deed, the Agency Agreement or
      these Conditions.

      Each Bondholder shall be solely responsible for making and continuing to make its own independent
      appraisal and investigation into the financial condition, creditworthiness, condition, affairs, status and
      nature of the Issuer and its Subsidiaries, and the Trustee shall not at any time have any responsibility
      for the same and each Bondholder shall not rely on the Trustee in respect thereof.


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15.   Further Issues

      The Issuer may from time to time, without the consent of the Bondholders, create and issue further
      bonds having the same terms and conditions as the Bonds in all respects (or in all respects except for
      the issue date and the timing for complying with the requirements set out in these Conditions in
      relation to the NDRC Post-issue Filing and the Foreign Debt Registration) and so that such further
      issue shall be consolidated and form a single series with the Bonds. Such further bonds shall be
      constituted by a deed supplemental to the Trust Deed.

16.   Notices

      All notices to Bondholders shall be validly given if mailed to them at their respective addresses in the
      register of Bondholders maintained by the Registrar or published in a leading newspaper having
      general circulation in Asia (which is expected to be the Asian Wall Street Journal) and, so long as the
      Bonds are listed on the Hong Kong Stock Exchange and the rules of that stock exchange so require,
      published in a leading newspaper having general circulation in Hong Kong (which is expected to be
      the South China Morning Post). Any such notice shall be deemed to have been given on the later of
      the date of such publication and the seventh day after being so mailed, as the case may be. A copy
      of all such notices to Bondholders (or a Bondholder) or the Trustee pursuant to these Conditions shall
      be given simultaneously to the Calculation Agent.

      As long as the Bonds are represented by the Global Certificate and the Global Certificate is held on
      behalf of Euroclear or Clearstream or an alternative clearing system, notices to Bondholders may be
      given by delivery of the relevant notice to Euroclear or Clearstream or the alternative clearing system,
      for communication by it to entitled accountholders in substitution for notification as required by the
      Conditions and such delivery shall be deemed to be valid for all purposes of these Conditions.

17.   Contracts (Rights of Third Parties) Act 1999

      No person shall have any right to enforce any term or condition of the Bonds under the Contracts
      (Rights of Third Parties) Act 1999 but this is without prejudice to the rights of Bondholders as
      contemplated in Condition 13.

18.   Governing Law and Jurisdiction

18.1 Governing Law

      The Bonds, the Trust Deed and the Agency Agreement and any non-contractual obligations arising out
      of or in connection with them are governed by, and shall be construed in accordance with, English law.

18.2 Jurisdiction

      The courts of Hong Kong are to have exclusive jurisdiction to settle any disputes which may arise out
      of or in connection with the Bonds and accordingly any legal action or proceedings arising out of or
      in connection with the Bonds and/or the Trust Deed (“Proceedings”) may be brought in such courts.
      Pursuant to the Trust Deed, the Issuer has irrevocably submitted to the jurisdiction of such courts.

18.3 Waiver of Immunity

      The Issuer has waived any right to claim sovereign or other immunity from jurisdiction or execution
      and any similar defense, and has irrevocably consented to the giving of any relief or the issue of any
      process, including, without limitation, the making, enforcement or execution against any property
      whatsoever (irrespective of its use or intended use) of any order or judgment made or given in
      connection with any Proceedings.


                                                     107
               TERMS AND CONDITIONS OF THE SERIES 2 BONDS

The following, subject to completion and amendment and other than the words in italics, is the text of the
Terms and Conditions of the Bonds which will appear on the reverse of each of the definitive certificates
evidencing the Bonds:

The issue of RMB1,916,000,000 in aggregate principal amount of U.S. Dollar settled zero coupon
convertible bonds due 2026 (the “Bonds”, which term shall include, unless the context requires otherwise,
any further Bonds issued in accordance with Condition 15 and consolidated and forming a single series
therewith) of Pharmaron Beijing Co., Ltd. (the “Issuer”) and the right of conversion into H Shares (as
defined in Condition 5.1.5) of the Issuer were authorised by the general mandate granted to the board of
directors of the Issuer by the shareholders of the Issuer at the annual general meeting of the Issuer held on
28 May 2021 and resolutions of the board of directors of the Issuer passed on 4 June 2021. The Bonds are
constituted by a trust deed (as amended and/or supplemented from time to time, the “Trust Deed”) to be
dated on or about June 18, 2021 (the “Issue Date”) and made between the Issuer and Citicorp International
Limited (the “Trustee”, which term shall, where the context so permits, include all other persons for the
time being acting as trustee or trustees under the Trust Deed) as trustee for the holders of the Bonds. The
Issuer has entered into a paying, conversion and transfer agency agreement (as amended and/or
supplemented from time to time, the “Agency Agreement”) to be dated on or about June 18, 2021 with the
Trustee, Citibank, N.A., London Branch as principal paying agent, principal conversion agent and principal
transfer agent (collectively in such capacities, the “Principal Agent”) and as registrar (the “Registrar”) and
the other paying agents, transfer agents and conversion agents appointed under it (each a “Paying Agent”,
a “Transfer Agent” or a “Conversion Agent” (as applicable) and together with the Registrar and the
Principal Agent, the “Agents”) relating to the Bonds. For the avoidance of doubt, references to the “Paying
Agents”, the “Transfer Agents” or, as the case may be, the “Conversion Agents” each include the Principal
Agent. References to the “Principal Agent”, the “Registrar” and the “Agents” below are references to the
principal agent, the registrar and the agents for the time being for the Bonds. These terms and conditions
(the “Conditions”) include summaries of, and are subject to, the detailed provisions of the Trust Deed and
the Agency Agreement. Unless otherwise defined, terms used in these Conditions have the meanings
specified in the Trust Deed. The Issuer has also entered into a calculation agency agreement (the
“Calculation Agency Agreement”) to be dated on or about June 18, 2021 with Conv-Ex Advisors Limited
(the “Calculation Agent”, which expression shall include any successor as calculation agent under the
Calculation Agency Agreement) whereby the Calculation Agent has been appointed to make certain
calculations in relation to the Bonds. The Bondholders are deemed to have notice of those provisions
applicable to them which are contained in the Calculation Agency Agreement. Copies of the Trust Deed, the
Agency Agreement and of the Calculation Agency Agreement are available for inspection reasonable times
during usual business hours (being between 9.00 a.m. and 3.00 p.m.) at the specified office of the Principal
Agent, being at the date of the Trust Deed at 20th Floor, Citi Tower, One Bay East, 83 Hoi Bun Road, Kwun
Tong, Kowloon, Hong Kong following prior written request and proof of holding and identity satisfactory
to the Principal Agent. The Bondholders (as defined in Condition 1.3) are entitled to the benefit of, are
bound by, and are deemed to have notice of, all the provisions of the Trust Deed and are deemed to have
notice of those provisions of the Agency Agreement and Calculation Agency Agreement applicable to them.

All capitalised terms that are not defined in the Conditions will have the meanings given to them in the Trust
Deed.

1.    Status; Form, Denomination and Title

1.1   Status

      The Bonds constitute direct, unsubordinated, unconditional and (subject to the provisions of Condition
      3.1) unsecured obligations of the Issuer and shall at all times rank pari passu and without any
      preference or priority among themselves. The payment obligations of the Issuer under the Bonds shall,
      save for such exceptions as may be provided by mandatory provisions of applicable law and subject
      to Condition 3.1, at all times rank at least equally with all of its other present and future direct,
      unsubordinated, unconditional and unsecured obligations.


                                                       108
1.2   Form and Denomination

      The Bonds are issued in registered form in the specified denomination of RMB2,000,000 each and
      integral multiples of RMB1,000,000 in excess thereof (an “Authorised Denomination”). A bond
      certificate (each a “Certificate”) will be issued to each Bondholder in respect of its registered holding
      of Bonds. Each Certificate will be numbered serially with an identifying number which will be
      recorded on the relevant Certificate and in the register of Bondholders (the “Register”) which the
      Issuer will procure to be kept by the Registrar.

      Upon issue, the Bonds will be represented by a Global Certificate registered in the name of a nominee
      of, and deposited with, a common depositary for Euroclear Bank SA/NV (“Euroclear”), as operator
      of the Euroclear System, and Clearstream Banking S.A. (“Clearstream”). The Conditions are
      modified by certain provisions contained in the Global Certificate.

      Except in the limited circumstances described in the Global Certificate, owners of interests in Bonds
      represented by the Global Certificate will not be entitled to receive definitive Certificates in respect
      of their individual holdings of Bonds. The Bonds are not issuable in bearer form.

1.3   Title

      Title to the Bonds passes only by transfer and registration in the Register as described in Condition 2.
      The holder of any Bond will (except as otherwise required by law or as ordered by a court of
      competent jurisdiction) be treated as its absolute owner for all purposes (whether or not it is overdue
      and regardless of any notice of ownership, trust or any interest in it or any writing on, or the theft or
      loss of, the Certificate issued in respect of it) and no person will be liable for so treating the holder.
      In these Conditions, “Bondholder” and (in relation to a Bond) “holder” means the person in whose
      name a Bond is registered.

2.    Registration and Transfers of Bonds; Issue of Certificates

2.1   Register

      The Issuer will cause the Register to be kept at the specified office of the Registrar outside the United
      Kingdom and in accordance with the terms of the Agency Agreement a register on which shall be
      entered the names and addresses of the holders of the Bonds and the particulars of the Bonds held by
      them and of all transfers, redemptions and conversions of the Bonds. Each Bondholder shall be
      entitled to receive only one Certificate in respect of its entire holding of Bonds.

2.2   Transfers

      Subject to Conditions 2.5 and 2.6 and the terms of the Agency Agreement, a Bond may be transferred
      in whole or in part in an Authorised Denomination by delivery of the Certificate issued in respect of
      that Bond, with the form of transfer on the back duly completed and signed by the holder or his
      attorney duly authorised in writing, to the specified office of the Registrar or of any of the Transfer
      Agents. No transfer of a Bond will be valid or effective unless and until entered on the Register. A
      Bond may be registered only in the name of, and transferred only to, a named person.

      Transfers of interests in the Bonds evidenced by the Global Certificate will be effected in accordance
      with the rules of the relevant clearing systems.




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2.3   Delivery of New Certificates

      2.3.1 Each new Certificate to be issued upon a transfer of Bonds will, within seven business days of
            receipt by the Registrar or, as the case may be, any Transfer Agent of the original Certificate and
            the form of transfer duly completed and signed, be made available for collection at the specified
            office of the Registrar or such Transfer Agent or, if so requested in the form of transfer, be
            mailed by uninsured mail at the risk of the holder entitled to the Bonds (but free of charge to
            the holder and at the Issuer’s expense) to the address specified in the form of transfer. The form
            of transfer is available at the specified office of the Registrar and each Transfer Agent.

           Except in the limited circumstances described herein, the Bonds will only be issued to the
           Bondholders in book-entry form and owners of interests in the Bonds will not be entitled to
           receive physical delivery of Certificates.

      2.3.2 Where only part of a principal amount of the Bonds (being that of one or more Bonds) in respect
            of which a Certificate is issued is to be transferred, converted, redeemed or repurchased, a new
            Certificate in respect of the Bonds not so transferred, converted, redeemed or repurchased will,
            within seven business days of delivery of the original Certificate to the Registrar or any Transfer
            Agent, be made available for collection at the specified office of the Registrar or such Transfer
            Agent or, if so requested in the form of transfer, be mailed by uninsured mail at the risk of the
            holder of the Bonds not so transferred, converted, redeemed or repurchased (but free of charge
            to the holder and at the Issuer’s expense) to the address of such holder appearing on the Register.

      2.3.3 For the purposes of this Condition 2.3, “business day” shall mean a day other than a Saturday
            or Sunday on which banks are open for business in the city in which the specified office of the
            Registrar (if a Certificate is deposited with it in connection with a transfer or conversion) or the
            Transfer Agent with whom a Certificate is deposited in connection with a transfer or conversion,
            is located.

2.4   Formalities Free of Charge

      Registration of a transfer of Bonds and issuance of new Certificates will be effected without charge
      subject to (i) the person making such application for transfer paying or procuring the payment of any
      taxes, duties and other governmental charges in connection therewith, (ii) the Registrar being satisfied
      with the documents of title and/or identity of the person making the application and (iii) such
      regulations as the Issuer may from time to time agree with the Registrar with the prior written
      approval of the Trustee or as the Registrar may promulgate with the prior written approval of the
      Trustee (and as initially set out in the Agency Agreement).

2.5   Restricted Transfer Periods

      No Bondholder may require the transfer of a Bond to be registered (i) during the period of seven days
      ending on (and including) the dates for payment of any principal pursuant to these Conditions; (ii)
      after a Conversion Notice (as defined in Condition 5.2.1) has been delivered with respect to such
      Bond; (iii) after a Put Option Notice (as defined in Condition 7.4) has been deposited in respect of
      such Bond or (iv) after a Relevant Event Put Exercise Notice (as defined in Condition 7.5) has been
      deposited in respect of such Bond, each such period being a “Restricted Transfer Period”.

2.6   Regulations

      All transfers of Bonds and entries on the Register will be made subject to the detailed regulations
      concerning transfer of Bonds scheduled to the Agency Agreement. The regulations may be changed
      by the Issuer, with the prior written approval of the Trustee and the Registrar. A copy of the current
      regulations will be made available (free of charge to the Bondholder and at the Issuer’s expense) by
      the Registrar to any Bondholder following written request and satisfactory proof of holding and
      identity and is available for inspection following written request and proof of holding and identity
      satisfactory to the Registrar at all reasonable times during normal business hours at the specified
      office of the Registrar.


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3.    Covenants

3.1   Negative Pledge

      So long as any Bond remains outstanding (as defined in the Trust Deed), the Issuer will not create or
      permit to subsist, and the Issuer will procure that no Subsidiary (as defined below) will create, or have
      outstanding, any mortgage, charge, pledge, lien or other form of encumbrance or security interest upon
      the whole or any part of its undertaking, assets or revenues (including any uncalled capital), present
      or future, to secure any Investment Securities (as defined below) or to secure any guarantee of or
      indemnity in respect of any Investment Securities unless, at the same time or prior thereto according
      to the Bonds the same security as is created or subsisting to secure any such Investment Securities,
      guarantee or indemnity or such other security as either (i) the Trustee shall in its absolute discretion
      deem not materially less beneficial to the interests of the Bondholders or (ii) shall be approved by an
      Extraordinary Resolution (as defined in the Trust Deed) of the Bondholders.

3.2   Undertakings Relating to Foreign Debt Registration

      The Issuer undertakes that it will (i) within 15 Registration Business Days after the Issue Date,
      register or cause to be registered with SAFE the Bonds pursuant to the Administrative Measures for
      Foreign Debt Registration and its operating guidelines, effective as of 13 May 2013 as amended from
      time to time and the Circular of the People’s Bank of China on Issues Concerning the Overall Macro
      Prudential Management System for Cross-border Financing (
                                 ) (the “Cross-Border Financing Circular”) (the “Foreign Debt
      Registration”), (ii) use its best endeavors to complete the Foreign Debt Registration and obtain a
      registration record from SAFE on or before the Registration Deadline and (iii) comply with all
      applicable PRC laws and regulations in relation to the Bonds, including but not limited to the Foreign
      Debt Registration, the Cross-Border Financing Circular and any implementing measures promulgated
      thereunder from time to time.

3.3   Notification to NDRC

      The Issuer undertakes that it will within 10 Registration Business Days after the Issue Date file or
      cause to be filed with the NDRC the requisite information and documents in accordance with the
      Circular on Promoting the Reform of the Administrative System on the Issuance by Enterprises of
      Foreign Debt Filings and Registrations (
             (         [2015]2044 )) issued by the NDRC and effective as of 14 September 2015 and any
      implementation rules as issued by the NDRC from time to time (the “NDRC Post-issue Filing”).

3.4   Notification of Submission of the NDRC Post-issue Filing and the completion of the Foreign Debt
      Registration

      The Issuer shall on or before the Registration Deadline and within 10 Registration Business Days after
      the later of (i) submission of the NDRC Post-issue Filing and (ii) receipt of the registration certificate
      from SAFE (or any other document evidencing the completion of the Foreign Debt Registration issued
      by SAFE), provide the Trustee with (a) a certificate in English substantially in the form scheduled to
      the Trust Deed signed by an Authorised Signatory (as defined in the Trust Deed) of the Issuer
      confirming the submission of the NDRC Post-issue Filing and the completion of the Foreign Debt
      Registration; and (b) copies of the relevant documents evidencing the NDRC Post-issue Filing and the
      Foreign Debt Registration, each certified in English as a true and complete copy of the original by an
      Authorised Signatory of the Issuer (the items specified in (a) and (b) together, the “Registration
      Documents”). In addition, the Issuer shall, within 10 Registration Business Days after the
      Registration Documents are delivered to the Trustee, give notice to the Bondholders (in accordance
      with Condition 16) confirming the submission of the NDRC Post-issue Filing and the completion of
      the Foreign Debt Registration.



                                                      111
      The Trustee shall have no obligation or duty to monitor or assist with or ensure the NDRC Post-Issue
      Filing is submitted or the Foreign Debt Registration is submitted or completed within the timeframe
      specified in Condition 3.2 and Condition 3.3, respectively, or to verify the accuracy, validity and/or
      genuineness of any documents in relation to or in connection with the NDRC Post-issue Filing and/or
      the Foreign Debt Registration and/or the Registration Documents or to translate or procure the
      translation into English of the documents in relation to or in connection with the NDRC Post-issue
      Filing or the Foreign Debt Registration or to give notice to the Bondholders confirming the completion
      of the NDRC Post-issue Filing and the Foreign Debt Registration, and shall not be liable to
      Bondholders or any other person for not doing so.

3.5   Definitions

      For the purposes of these Conditions:

      “Hong Kong” means the Hong Kong Special Administrative Region of the People’s Republic of
      China;

      “Investment Securities” means any present or future indebtedness incurred outside the PRC in the
      form of, or represented by, bonds, debentures, notes, loan stock, bearer participation certificates,
      depositary receipts, certificates of deposit or other investment securities which represent indebtedness
      and are for the time being, or are intended to be or capable of being, quoted, listed, ordinarily dealt
      in or traded on any stock exchange or over-the-counter or other securities market;

      “NDRC” means the National Development and Reform Commission of the PRC or its local
      counterparts;

      “person” means any individual, corporation, partnership, limited liability company, joint venture,
      trust, unincorporated organisation or government or any agency or political subdivision thereof;

      “PRC” means the People’s Republic of China, which, for the purpose of these Conditions only, shall
      exclude Hong Kong, the Macau Special Administrative Region of the People’s Republic of China and
      Taiwan;

      “Registration Business Day” means a day, other than a Saturday, Sunday or public holiday, on which
      commercial banks are generally open for business in Beijing;

      “Registration Deadline” means the day falling 90 Registration Business Days after the Issue Date;

      “SAFE” means the State Administration of Foreign Exchange of the PRC or its local branch; and

      “Subsidiary” or “subsidiary” means (i) in relation to any person, any company or other business
      entity of which that person owns or controls (either directly or through one or more other Subsidiaries)
      more than 50 per cent. of the registered share capital or issued share capital or other ownership interest
      having ordinary voting power to elect directors, managers or trustees of such company or other
      business entity or (ii) any company or other business entity which at any time has its accounts
      consolidated with those of that person or which, under the laws of Hong Kong or the PRC, or in
      accordance with generally accepted accounting principles applicable in the PRC from time to time,
      should have its accounts consolidated with those of that person.




                                                      112
4.    Interest

      The Bonds are zero coupon and do not bear interest unless, upon due presentation thereof, payment
      of principal and premium (if any) is improperly withheld or refused. In such event, such unpaid
      amount shall bear interest at the rate of 2 per cent. per annum over the yield to maturity (both before
      and after judgment) until whichever is the earlier of (a) the day on which all sums due in respect of
      such Bond up to that day are received by or on behalf of the relevant holder and (b) the day falling
      seven days after the Trustee or the Principal Agent has notified Bondholders of receipt of all sums due
      in respect of all the Bonds up to that seventh day (except to the extent that there is failure in the
      subsequent payment to the relevant holders under these Conditions). If interest is required to be
      calculated for a period of less than one year, it will be determined on the basis of a 360-day year
      consisting of 12 months of 30 days each and, in the case of an incomplete month, the number of days
      elapsed.

5.    Conversion

5.1   Conversion Right

      5.1.1 Conversion Right and Conversion Period: Subject as hereinafter provided and in accordance
            with the provisions of the Trust Deed, Bondholders have the right to convert their Bonds into
            H Shares credited as fully paid at any time during the Conversion Period referred to below. The
            right of a Bondholder to convert any Bond into H Shares is called the “Conversion Right”. The
            number of H Shares to be issued on conversion of a Bond will be determined by the Calculation
            Agent by dividing the principal amount of the Bond to be converted (translated into HK dollars
            at the fixed rate of RMB1.00 – HK$1.2143) (the “Fixed Exchange Rate”) by the Conversion
            Price (as defined in Condition 5.1.3) in effect on the Conversion Date (as defined in Condition
            5.2.1). A Conversion Right may only be exercised in respect of an Authorised Denomination for
            one or more Bonds. If more than one Bond held by the same holder is converted at any one time
            pursuant to any one Conversion Notice, the number of H Shares to be issued upon such
            conversion will be calculated on the basis of the aggregate RMB principal amount of the Bonds
            to be converted.

           Subject to and upon compliance with these Conditions (including without limitation Condition
           5.1.4), the Conversion Right attaching to any Bond may be exercised, at the option of the holder
           thereof, at any time on and after 41st day after the Issue Date up to the close of business (at the
           place where the Certificate evidencing such Bond is deposited for conversion) on the date falling
           10 working days prior to the Maturity Date (as defined in Condition 7.1) (both days inclusive)
           or if such Bond shall have been called for redemption by the Issuer before the Maturity Date,
           then up to and including the close of business (at the place aforesaid) on a date no later than 10
           working days (both days inclusive and at the place aforesaid) prior to the date fixed for
           redemption thereof; provided that no Conversion Right may be exercised in respect of a Bond
           where the holder shall have exercised its right to require the Issuer to redeem or repurchase such
           Bond pursuant to Condition 7.4 or Condition 7.5 or during a Restricted Conversion Period (both
           dates inclusive) (as defined below); provided further that the Conversion Right is exercised
           subject to any applicable fiscal or other laws or regulations or as hereafter provided in these
           Conditions (the “Conversion Period”).

           A Conversion Right may not be exercised in relation to any Bond during any period:

           (i)    commencing, for an annual shareholder general meeting of the Issuer, on the date falling
                  20 days prior to that meeting and ending on the date of that meeting, or, for an
                  extraordinary shareholder general meeting of the Issuer, on the date falling 15 days prior
                  to that meeting and ending on the date of that meeting;

           (ii)   commencing the date falling five working days prior to the record date set by the Issuer
                  for the purpose of distribution of any dividend and ending on such record date; or

           (iii) commencing on such date and for such period as determined by applicable law from time
                 to time that the Issuer is required to close its register,


                                                    113
     (each of the periods set out in (i), (ii) and (iii) above, subject as provided in the following
     paragraph, a “Restricted Conversion Period”).

     The Issuer will give notice of any such Restricted Conversion Period to the Bondholders (in
     accordance with Condition 16) and the Trustee and Agents not less than five working days prior
     to the commencement of any such Restricted Conversion Period, failing which the relevant
     Restricted Conversion Period shall not apply.

     For the purpose of this Condition 5.1.1, “working day” means a day other than a Saturday,
     Sunday or a public holiday on which commercial banks and foreign exchange markets are open
     for business in London.

5.1.2 Fractions of H Shares: Fractions of H Shares will not be issued on conversion and no cash
      payments or other adjustments will be made in lieu thereof. However, if the Conversion Right
      in respect of more than one Bond is exercised pursuant to any one Conversion Notice, the
      number of such H Shares to be issued in respect thereof shall be calculated by the Calculation
      Agent on the basis of the aggregate principal amount of such Bonds being so converted and
      rounded down to the nearest whole number of H Shares.

     Notwithstanding the foregoing, in the event of a consolidation or re-classification of H Shares
     by operation of law or otherwise occurring after June 8, 2021 which reduces the number of H
     Shares outstanding, the Issuer will upon conversion of Bonds, in respect of which the
     Registration Date falls after the record date or other due date for the establishment of entitlement
     for such consolidation or re-classification, pay a sum (but only if such sum exceeds
     U.S.$100.00) in cash in U.S. dollars (by means of a U.S. dollar cheque drawn on a bank that
     processes payments in U.S. dollars or by transfer to a U.S. dollar account maintained by the
     payee) in either case in accordance with instructions given by the relevant Bondholder in the
     Conversion Notice, and no later than five Payment Business Days following the Conversion
     Date (or, in the case of Additional H Shares, the Reference Date) equal to the product of (i) the
     fraction of any H Share not delivered pursuant to the above paragraph and (ii) the Volume
     Weighted Average Price of an H Share converted if necessary into U.S. dollars at the Prevailing
     Rate on the relevant Conversion Date, as determined by the Calculation Agent.

5.1.3 Conversion Price: The price at which H Shares will be issued upon conversion (the “Conversion
      Price”) will initially be HK$229.50 per H Share but will be subject to adjustment in the manner
      provided in Condition 5.3, subject as provided in Condition 5.6.

5.1.4 Revival and/or survival after Default: Notwithstanding the provisions of Condition 5.1.1, if (i)
      the Issuer shall default in making payment in full in respect of any Bond which shall have been
      called or put for redemption on the date fixed for redemption thereof, (ii) any Bond has become
      due and payable prior to the Maturity Date by reason of the occurrence of any of the events
      referred to in Condition 9 or (iii) any Bond is not redeemed on the Maturity Date in accordance
      with Condition 7.1, the Conversion Right attaching to such Bond will revive and/or will continue
      to be exercisable up to, and including, the close of business (at the place where the Certificate
      evidencing such Bond is deposited for conversion) on the date upon which the full amount of
      the moneys payable in respect of such Bond has been duly received by the Principal Agent or
      the Trustee and notice of such receipt has been duly given to the Bondholders in accordance with
      Condition 16 and, notwithstanding the provisions of Condition 5.1.1, any Bond in respect of
      which the Certificate and Conversion Notice are deposited for conversion prior to such date shall
      be converted on the relevant Conversion Date notwithstanding that the full amount of the
      moneys payable in respect of such Bond shall have been received by the Principal Agent or the
      Trustee before such Conversion Date or that the Conversion Period may have expired before
      such Conversion Date.




                                               114
    5.1.5 Meaning of H Shares, A Shares, Ordinary Shares: As used in these Conditions, the expression
          (i) “H Shares” means ordinary foreign shares with a par value of RMB1.00 each issued by the
          Issuer which are traded in HK dollars on the Hong Kong Stock Exchange (ISIN:
          CNE100003PG4); (ii) “A Shares” means ordinary domestic shares of RMB1.00 each issued by
          the Issuer which are traded in Renminbi on the Shenzhen Stock Exchange; and (iii) “Ordinary
          Shares” means the H Shares, the A Shares and any fully-paid and non-assessable shares of any
          class or classes of the ordinary shares of the Issuer authorised after the date of the issue of the
          Bonds which have no preference in respect of dividends or of amounts payable in the event of
          any voluntary or involuntary liquidation or dissolution of the Issuer.

Conversion Procedure

    5.1.6 Conversion Notice: Conversion Rights may be exercised by a Bondholder during the Conversion
          Period by delivering the relevant Certificate to the specified office of any Conversion Agent
          during its usual business hours (being 9:00 a.m. to 3:00 p.m., Monday to Friday on which
          commercial banks are open for business in the city of the specified office of the Conversion
          Agent) accompanied by a duly completed and signed notice of conversion (a “Conversion
          Notice”) in the form (for the time being current and being substantially in the form scheduled
          to the Agency Agreement) obtainable from any Conversion Agent, together with (i) the relevant
          Certificate; and (ii) certification by the Bondholder, in the form obtainable from any Conversion
          Agent, as may be required under the laws of the PRC, Hong Kong or any jurisdiction in which
          the specified office of such Conversion Agent is located. Conversion Rights shall be exercised
          subject in each case to any applicable fiscal or other laws or regulations applicable in the
          jurisdiction in which the specified office of the Conversion Agent to whom the relevant
          Conversion Notice is delivered is located.

         Holders of beneficial interests in the Global Certificate may exercise Conversion Rights through
         the holder of the Global Certificate in accordance with the rules of the applicable clearing
         system.

         If such delivery is made after 3.00 p.m. on any business day or on a day which is not a business
         day, in each case in the place of the specified office of the Conversion Agent, such delivery shall
         be deemed for all purposes of these Conditions to have been made on the next business day
         following such day. If such delivery is made during a Restricted Conversion Period, such
         delivery shall be deemed for all purposes of these Conditions to have been made on the business
         day following (in the place of the specified office of the Conversion Agent) the last day of such
         Restricted Conversion Period unless such date shall fall outside the Conversion Period.

         Any determination as to whether any Conversion Notice has been duly completed and properly
         delivered shall be made by the relevant Conversion Agent and shall, save in the case of manifest
         error, be conclusive and binding on the Issuer, the Trustee, the Agents and the relevant
         Bondholder.

         A Conversion Notice, once delivered, shall be irrevocable and may not be withdrawn without the
         Issuer’s consent.

         The conversion date in respect of a Bond (the “Conversion Date”) shall be deemed to be the H
         Share Stock Exchange Business Day (as defined in Condition 5.8) immediately following the
         date on which delivery of the Certificate in respect of such Bond and such Conversion Notice
         (and, if applicable, any such certificate) is made (or deemed to be made) as provided above is
         so made or given).




                                                   115
5.1.7 Stamp Duty etc.: A Bondholder delivering a Certificate in respect of a Bond for conversion must
      pay directly to the relevant authorities or party any taxes and duties, including capital, stamp,
      issue, excise, transfer, registration and other similar taxes and duties and transfer costs
      (“Duties”) in any applicable jurisdiction arising on conversion (other than any Duties payable
      in the PRC or Hong Kong or, if relevant, in the place of the Alternative Stock Exchange, by the
      Issuer in respect of the allotment and issue of H Shares and listing of the H Shares on the Hong
      Kong Stock Exchange or the Alternative Stock Exchange (as the case may be) on conversion,
      such Duties being the “Issuer Duties”) (such Duties and Issuer Duties are collectively known
      as “Taxes”). The Issuer will pay all other expenses arising from the issue of H Shares on
      conversion of the Bonds and all charges (together, the “Conversion Expenses”) of the Agents
      and the share transfer agent for the H Shares (the “Share Transfer Agent”). The Bondholder
      (and, if different, the person to whom the H Shares are to be issued) must declare in the relevant
      Conversion Notice that any amounts payable to the relevant tax authorities or party in settlement
      of Duties (other than the Issuer Duties) payable pursuant to this Condition 5.2.2 have been paid.

     If the Issuer fails to pay any Issuer Duties or Conversion Expenses, the relevant holder shall be
     entitled to tender and pay the same and the Issuer, as a separate and independent stipulation,
     covenants to reimburse and indemnify each Bondholder in respect of any payment thereof and
     any penalties payable in respect thereof.

     Such Bondholder must also pay all, if any, Duties (other than Issuer Duties) imposed on it and
     arising by reference to any disposal or deemed disposal of a Bond or interest therein in
     connection with the exercise of Conversion Rights by it.

     Neither the Trustee nor the Agents shall be responsible for determining whether such Taxes or
     Conversion Expenses are payable or the amount thereof and shall not be responsible or liable for
     any failure by the Issuer or any Bondholder to pay any such amount.

5.1.8 Delivery of H Shares Upon Conversion, Registration, Retroactive Adjustments:

     (i)   As soon as practicable, and in any event not later than seven H Share Stock Exchange
           Business Days (excluding any H Share Stock Exchange Business Day that falls within a
           Restricted Conversion Period) after the relevant Conversion Date (or, in the case of
           Additional H Shares, the relevant Reference Date), the Issuer will, in the case of Bonds
           converted on exercise of the Conversion Right and in respect of which a duly completed
           Conversion Notice has been delivered and the relevant Certificate and certification and
           amounts payable by the relevant Bondholder deposited or paid as required by Conditions
           5.2.1 and 5.2.2, register the person designated for the purpose in the Conversion Notice as
           holder of the relevant number of H Shares in the Issuer’s H share register and will, if such
           Bondholder has so requested in such Conversion Notice and to the extent permitted under
           applicable law and the rules and procedures of the Central Clearing and Settlement System
           of Hong Kong (“CCASS”) effective from time to time, take all action reasonably necessary
           to enable the H Shares to be delivered through CCASS for so long as the H Shares are
           listed on the Hong Kong Stock Exchange; or will make such certificate or certificates
           available for collection at the office of the Issuer’s share registrar in Hong Kong (being,
           at the time of issue of the Bonds, Computershare Hong Kong Investor Services Limited at
           Shops 1712-1716, 17th Floor, Hopewell Centre, 183 Queen’s Road East, Hong Kong)
           notified to Bondholders in accordance with Condition 16 or, if so requested in the relevant
           Conversion Notice, cause its share registrar to mail (at the risk, and, if sent at the request
           of such person otherwise than by ordinary mail, at the expense, of the person to whom such
           certificate or certificates are sent) such certificate or certificates to the person and at the
           place specified in the Conversion Notice, together (in either case) with any other securities,
           property or cash required to be delivered upon conversion and such assignments and other
           documents (if any) as may be required by law to effect the transfer thereof.


                                               116
           (ii)   The delivery of the H Shares to the converting Bondholder (or such person designated in
                  the relevant Conversion Notice) in the manner contemplated in Condition 5.2.3(i) will be
                  deemed to satisfy the Issuer’s obligation to pay any amounts under such converted Bonds.
                  The person designated in the Conversion Notice will become the holder of record of the
                  number of H Shares issuable upon conversion with effect from the date he is registered as
                  such in the Issuer’s register of members for H shares (the “Registration Date”, or, in the
                  case of Additional H Shares, the “Additional Registration Date”, in each case in respect
                  of such exercise of Conversion Rights). The H Shares issued upon exercise of the
                  Conversion Rights will be fully paid up and will in all respects rank pari passu with, and
                  within the same class as, the H Shares in issue on the relevant Registration Date (or, in the
                  case of Additional H Shares, the Additional Registration Date) except for any right
                  excluded by mandatory provisions of applicable law. Save as set out in these Conditions,
                  a holder of H Shares issued on exercise of the Conversion Rights shall not be entitled to
                  any rights, distributions or other payments the record date or due date for the establishment
                  of entitlement for which precedes the relevant Registration Date (or, in the case of
                  Additional H Shares, the Additional Registration Date).

           (iii) If (A) the Registration Date in relation to any exercise of Conversion Rights shall be after
                 the Applicable RA Date in respect of any adjustment to the Conversion Price pursuant to
                 Condition 5.3 and (B) the Conversion Date in relation to such exercise shall be before the
                 date on which such adjustment to the Conversion Price becomes effective under the
                 relevant Condition (any such adjustment, a “Retroactive Adjustment”), upon the relevant
                 adjustment to the Conversion Price becoming effective under the relevant Condition the
                 Issuer shall procure the issue to the converting Bondholder (in accordance with the
                 instructions contained in the Conversion Notice (subject to any applicable laws or
                 regulations)), such additional number of H Shares (“Additional H Shares”) as, together
                 with the Reference H Shares issued or to be issued on conversion of the relevant Bond, is
                 equal to the number of Reference H Shares which would have been required to be issued
                 on conversion of such Bond if the relevant adjustment to the Conversion Price under the
                 relevant Condition had been effective on the relevant Conversion Date (such number of
                 Reference H Shares as aforesaid being for this purpose calculated as the Reference H
                 Shares in respect of such exercise of Conversion Rights determined for this purpose by
                 reference to such deemed Conversion Price as aforesaid.

5.2   Adjustments to Conversion Price

      Upon the occurrence of any of the events described below, the Conversion Price shall be adjusted as
      follows:

      5.2.1 Consolidation, Subdivision or Re-classification: If and whenever there shall be an alteration to
            the nominal value of the H Shares as a result of consolidation, subdivision or re-classification,
            the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately
            before such alteration by the following fraction:

                                                       A
                                                       B

           Where:

           A      is the nominal amount of one H Share immediately after such alteration; and

           B      is the nominal amount of one H Share immediately before such alteration.

                  Such adjustment shall become effective on the date that such consolidation, subdivision or
                  re-classification takes effect.


                                                      117
5.2.2 Capitalisation of Profits or Reserves:

     (i)    If and whenever the Issuer shall issue Ordinary Shares of any class credited as fully paid
            to the holders of such Ordinary Shares (“Ordinary Shareholders”) by way of
            capitalisation of profits or reserves, including Ordinary Shares of such class paid up out of
            distributable profits or reserves and/or share premium account (except any Scrip
            Dividend), the Conversion Price shall be adjusted by multiplying the Conversion Price in
            force immediately before such issue by the following fraction:

                                                  A
                                                  B

            Where:

            A    is the aggregate nominal amount of the issued Ordinary Shares immediately before
                 such issue; and

            B    is the aggregate nominal amount of the issued Ordinary Shares immediately after
                 such issue.

            Where (i) such issue is made in respect of more than one class of Ordinary Shares, (ii) any
            such class of Ordinary Shares is the H Shares class, and (iii) there is a record date or other
            due date for the establishment of entitlement for such issue in respect of the H Shares, such
            date shall be deemed to be the record date in respect of such offer for the purpose of these
            Conditions.

            Such adjustment shall become effective on the date of issue of such Ordinary Shares or if
            a record date is fixed therefor, immediately after such record date (or, if later, the first date
            on which the fraction above is capable of being determined in accordance with these
            Conditions).

     (ii)   In the case of an issue of Ordinary Shares of any class by way of a Scrip Dividend where
            the Current Market Price on the date of announcement of the terms of such issue of
            Ordinary Shares (for the purpose of this Condition 5.3.2(ii), the “Determination Date”)
            multiplied by the number of Scrip Dividend issued exceeds 105 per cent. of the amount of
            the Relevant Cash Dividend or the relevant part thereof and which would not have
            constituted a Capital Distribution, the Conversion Price shall be adjusted by multiplying
            the Conversion Price in force immediately before the issue of such Scrip Dividend by the
            following fraction:

                                                A+B
                                                A+C

            Where:

            A    is the aggregate nominal amount of the issued Ordinary Shares of all classes
                 immediately before the Determination Date;

            B    is the aggregate nominal amount of such Scrip Dividend multiplied by a fraction of
                 which (i) the numerator is the amount of the whole, or the relevant part, of the
                 Relevant Cash Dividend and (ii) the denominator is such aggregate Current Market
                 Price of the Scrip Dividend issued in lieu of the whole, or the relevant part, of the
                 Relevant Cash Dividend; and

            C    is the aggregate nominal amount of such Scrip Dividend,


                                                 118
           or (at the Issuer’s sole discretion, following consultation with the Calculation Agent) by
           making such other adjustment to the Conversion Price as determined to be appropriate by
           an Independent Financial Advisor.

           Where (i) such issue is made in respect of more than one class of Ordinary Shares, (ii) any
           such class of Ordinary Shares is the H Shares class, and (iii) there is a record date or other
           due date for the establishment of entitlement for such issue in respect of the H Shares, such
           date shall be deemed to be the record date in respect of such offer for the purpose of these
           Conditions.

           Such adjustment shall become effective on the date of issue of such Ordinary Shares or if
           a record date is fixed therefor, immediately after such record date (or, if later, the first date
           on which the fraction above is capable of being determined in accordance with these
           Conditions).

5.2.3 Capital Distributions: If and whenever the Issuer shall pay or make any Capital Distribution to
      the Ordinary Shareholders (except to the extent that the Conversion Price falls to be adjusted
      under Condition 5.3.2 above), the Conversion Price shall be adjusted by multiplying the
      Conversion Price in force immediately before such Capital Distribution by the following
      fraction:

                                               A–B
                                                A

     Where:

     A     is the sum of the products of, in respect of each of the classes of Ordinary Shares in issue
           immediately prior to the Determination Date, (i) the number of Ordinary Shares of such
           class in issue on the Determination Date and (ii) the Current Market Price per Ordinary
           Share of such class on the date on which the Capital Distribution is first publicly
           announced (for the purpose of this Condition 5.3.3, the “Determination Date”); and

     B     is the aggregate Fair Market Value of the aggregate Capital Distribution in respect of each
           such class of Ordinary Shares.

     Where (i) such Capital Distribution is paid or made in respect of more than one class of Ordinary
     Shares, (ii) any such class of Ordinary Shares is the H Shares class, and (iii) there is a record
     date or other due date for the establishment of entitlement for such Capital Distribution in
     respect of the H Shares, such date shall be deemed to be the record date in respect of such Capital
     Distribution for the purpose of these Conditions.

     Such adjustment shall become effective on the date that such Capital Distribution is actually
     made or, if a record date is fixed therefor, immediately after such record date (or, if later, the
     first date on which the fraction above is capable of being determined in accordance with these
     Conditions).

     For the purpose of the above, Fair Market Value shall (subject as provided in the definition of
     “Fair Market Value” (as defined in Condition 5.8)) be determined as at the Determination Date.
     In making any calculation pursuant to this Condition 5.3.3, such adjustments (if any) shall be
     made as an Independent Financial Advisor (or, if the Calculation Agent determines in its sole
     discretion it is capable of making such determination in its capacity as Calculation Agent, the
     Calculation Agent) may consider appropriate to reflect (i) any consolidation or subdivision of
     the Ordinary Shares, (ii) issues of Ordinary Shares by way of capitalisation of profits or reserves,
     or any like or similar event or (iii) the modification of any rights to dividends of Ordinary
     Shares.


                                                119
5.2.4 Rights Issues of Shares or Options over Shares: If and whenever the Issuer shall issue Ordinary
      Shares of one or more classes to all or substantially all Ordinary Shareholders of such classes
      by way of rights, or issue or grant to all or substantially all Ordinary Shareholders of such
      classes by way of rights, options, warrants or other rights to subscribe for, purchase or otherwise
      acquire any Ordinary Shares of such classes, in each case at a consideration less than 95 per cent.
      of the Current Market Price per H Share on the date of the first public announcement of the terms
      of the issues or grants (for the purpose of this Condition 5.3.4, the “Determination Date”), the
      Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately
      before such issues or grants by the following fraction:

                                           A + B1 + B2
                                           A + C1 + C2

     Where:

     A     is the aggregate number of Ordinary Shares of all classes in issue immediately before the
           Determination Date;

     B1    is the number of Ordinary Shares of one class which the aggregate consideration (if any)
           receivable for the Ordinary Shares of such class issued by way of rights or for the options
           or warrants or other rights issued or granted by way of rights and for the total number of
           Ordinary Shares of such class comprised therein would subscribe for, purchase or
           otherwise acquire at such Current Market Price;

     B2    where applicable, is the number of Ordinary Shares of a second class which the aggregate
           consideration (if any) receivable for the Ordinary Shares of such class issued by way of
           rights or for the options or warrants or other rights issued or granted by way of rights and
           for the total number of Ordinary Shares of such class comprised therein would subscribe
           for, purchase or otherwise acquire at such Current Market Price;

     C1    is the aggregate number of Ordinary Shares of one class to be issued or, as the case may
           be, the maximum number of Ordinary Shares of such class which may be issued upon
           exercise of such options, warrants or rights calculated as at the date of issue of such
           options, warrants or rights in respect thereof at the initial subscription, purchase or
           acquisition price or rate; and

     C2    where applicable, is the aggregate number of Ordinary Shares of a second class issued or,
           as the case may be, the maximum number of Ordinary Shares of such class which may be
           issued upon exercise of such options, warrants or rights calculated as at the date of issue
           of such options, warrants or rights in respect thereof at the initial subscription, purchase
           or acquisition price or rate.

     Where (i) such issue or grant is made in respect of more than one class of Ordinary Shares, (ii)
     any such class of Ordinary Shares is the H Shares class, and (iii) there is a record date or other
     due date for the establishment of entitlement for such issue or grant in respect of the H Shares,
     such date shall be deemed to be the record date in respect of such issue or grant for the purpose
     of these Conditions.

     Such adjustment shall become effective on the date of issue of such Ordinary Shares or issue or
     grant of such options, warrants or other rights (as the case may be) or, where if a record date is
     fixed therefor, immediately after such record date (or, if later, the first date on which the fraction
     above is capable of being determined in accordance with these Conditions).



                                                120
5.2.5 Rights Issues of Other Securities: In respect of each class of Ordinary Shares, if and whenever
      the Issuer shall issue any securities (other than Ordinary Shares or options, warrants or other
      rights to subscribe for, purchase or otherwise acquire Ordinary Shares) to all or substantially all
      Ordinary Shareholders of such class by way of rights, or issue or grant to all or substantially all
      Ordinary Shareholders of such class by way of rights, options, warrants or other rights to
      subscribe for, purchase or otherwise acquire any securities (other than Ordinary Shares or
      options, warrants or other rights to subscribe for, purchase or otherwise acquire Ordinary
      Shares), the Conversion Price shall be adjusted by multiplying the Conversion Price in force
      immediately before such issue or grant by the following fraction:

                                              A–B
                                               A

     Where:

     A     is the sum of the products of, in respect of each of the classes of Ordinary Shares classes
           in issue immediately prior to the Determination Date, (i) the number of Ordinary Shares
           of such class and (ii) the Current Market Price per Ordinary Share of such class on the date
           on which the terms of such issue or grant are first publicly announced (for the purpose of
           this Condition 5.3.5, the “Determination Date”); and

     B     is the aggregate Fair Market Value of the aggregate securities, rights, options or warrants
           (as the case may be) attributable to the Ordinary Shares in respect of each such class of
           Ordinary Shares.

     Where (i) such issue or grant is made in respect of more than one class of Ordinary Shares, (ii)
     any such class of Ordinary Shares is the H Shares class, and (iii) there is a record date or other
     due date for the establishment of entitlement for such issue or grant in respect of the H Shares,
     such date shall be deemed to be the record date in respect of such issue or grant for the purpose
     of these Conditions.

     Such adjustment shall become effective on the date of issue of the securities or the issue or grant
     of such rights, options or warrants (as the case may be) or where a record date is fixed therefor,
     immediately after such record date (or, if later, the first date on which the fraction above is
     capable of being determined in accordance with these Conditions).

     For the purpose of the above, Fair Market Value shall (subject as provided in the definition of
     “Fair Market Value” (as defined in Condition 5.8)) be determined as at the Determination Date.

5.2.6 Issues at Less than Current Market Price: If and whenever the Issuer shall issue (otherwise than
      as mentioned in Condition 5.3.4 above) wholly for cash or for no consideration any Ordinary
      Shares of one or more classes (other than H Shares issued on the exercise of Conversion Rights
      or on the exercise of any other rights of conversion into, or exchange or subscription for,
      Ordinary Shares) or issue or grant (otherwise than as mentioned in Condition 5.3.4 above)
      wholly for cash or for no consideration options, warrants or other rights to subscribe for,
      purchase or otherwise acquire Ordinary Shares of one or more classes, in each case at a
      consideration which is less than 95 per cent. of the Current Market Price per H Share on the date
      of announcement of the terms of such issues (for the purpose of this Condition 5.3.6, the
      “Determination Date”), the Conversion Price shall be adjusted by multiplying the Conversion
      Price in force immediately before such issues by the following fraction:

                                          A + B1 + B2
                                          A + C1 + C2




                                               121
     Where:

     A     is the aggregate number of Ordinary Shares of all classes in issue immediately before the
           Determination Date;

     B1    is the number of Ordinary Shares of one class which the aggregate consideration (if any)
           receivable for the issue of such additional Ordinary Shares of such class would purchase
           at such Current Market Price;

     B2    where applicable, is the number of Ordinary Shares of a second class which the aggregate
           consideration (if any) receivable for the issue of such additional Ordinary Shares of such
           class would purchase at such Current Market Price;

     C1    is the aggregate number of Ordinary Shares of one class issued, or as the case may be, the
           maximum number of Ordinary Shares of such class to be issued on the exercise of such
           options, warrants or other rights at the initial exercise price or rate; and

     C2    where applicable, is the aggregate number of Ordinary Shares of a second class issued, or
           as the case may be, the maximum number of Ordinary Shares of such class to be issued on
           the exercise of such options, warrants or other rights at the initial exercise price or rate.

     References to “additional Ordinary Shares” in the above formula shall, in the case of an issue
     by the Issuer of options, warrants or other rights to subscribe or purchase Ordinary Shares, mean
     such Ordinary Shares to be issued assuming that such options, warrants or other rights are
     exercised in full at the initial exercise price or rate on the date of issue or grant of such options,
     warrants or other rights.

     Where (i) such issue comprises more than one class of Ordinary Shares (or, options, warrants or
     other rights to subscribe for, purchase or otherwise acquire Ordinary Shares of more than one
     class) and (ii) any such class of Ordinary Shares is the H Shares class, the date of issue of such
     Ordinary Shares (or, as the case may be, the date of issue or grant of such options, warrants or
     other rights) shall be deemed to be the date of issue of the H Shares (or, as the case may be, the
     date of issue or grant of the options, warrants or other rights to subscribe for, purchase or
     otherwise acquire H Shares) for the purpose of these Conditions.

     Such adjustment shall become effective on the date of issue of such additional Ordinary Shares
     or, as the case may be, the issue or grant of such options, warrants or other rights (or, if later,
     the first date on which the fraction above is capable of being determined in accordance with
     these Conditions).

5.2.7 Other Issues at less than Current Market Price: Save in the case of an issue of securities arising
      from a conversion or exchange of other securities in accordance with the terms applicable to
      such securities themselves falling within this Condition 5.3.7, if and whenever the Issuer or any
      of its Subsidiaries (otherwise than as mentioned in Condition 5.3.4, Condition 5.3.5 or Condition
      5.3.6), or (at the direction or request of or pursuant to any arrangements with the Issuer or any
      of its Subsidiaries) any other company, person or entity shall issue any securities wholly for cash
      or for no consideration (other than the Bonds, which shall be deemed to exclude any further
      bonds issued pursuant to Condition 15) which by their terms of issues carry rights of conversion
      into, or exchange or subscription for, Ordinary Shares of one or more classes to be issued by the
      Issuer upon conversion, exchange or subscription, in each case at a consideration which is less
      than 95 per cent. of the Current Market Price per H Share on the date of announcement of the
      terms of issues of such securities (for the purpose of this Condition 5.3.7, the “Determination
      Date”), the Conversion Price shall be adjusted by multiplying the Conversion Price in force
      immediately before such issues by the following fraction:

                                           A + B1 + B2
                                           A + C1 + C2


                                                122
     Where:

     A     is the aggregate number of Ordinary Shares of all classes in issue immediately before the
           Determination Date;

     B1    is the number of Ordinary Shares of one class which the aggregate consideration receivable
           by the Issuer for the Ordinary Shares of such class to be issued on conversion or exchange
           or on exercise of the right of subscription attached to such securities would purchase at
           such Current Market Price;

     B2    where applicable, is the number of Ordinary Shares of a second class which the aggregate
           consideration receivable by the Issuer for the Ordinary Shares of such class to be issued
           on conversion or exchange or on exercise of the right of subscription attached to such
           securities would purchase at such Current Market Price;

     C1    is the maximum number of Ordinary Shares of one class to be issued on conversion or
           exchange of such securities or on the exercise of such rights of subscription attached
           thereto at the initial conversion, exchange or subscription price or rate; and

     C2    where applicable, is the maximum number of Ordinary Shares of a second class to be
           issued on conversion or exchange of such securities or on the exercise of such rights of
           subscription attached thereto at the initial conversion, exchange or subscription price or
           rate.

     Where (i) such issue comprises securities which by their terms of issues carry rights of
     conversion into, or exchange or subscription for, more than one class of Ordinary Shares and (ii)
     any such class of Ordinary Shares is the H Shares class, the date of issue of the securities which
     by their terms of issues carry rights of conversion into, or exchange or subscription for, H Shares
     shall be deemed to be the date of issue of all such securities for the purpose of these Conditions.

     Such adjustment shall become effective on the date of issue of such securities (or, if later, the
     first date on which the fraction above is capable of being determined in accordance with these
     Conditions).

5.2.8 Modification of Rights of Conversion etc.: If and whenever there shall be any modification of
      the rights of conversion, exchange, subscription, purchase or acquisition attaching to any such
      securities (other than the Bonds) as are mentioned in Condition 5.3.7 (other than in accordance
      with the terms of such securities) so that the consideration per Ordinary Share of one or more
      classes (for the number of Ordinary Shares of such classes available on conversion, exchange,
      subscription, purchase or acquisition following the modification) is reduced and, in each case,
      is less than 95 per cent. of the Current Market Price per H Share on the date of announcement
      of the proposals for such modifications (for the purpose of this Condition 5.3.8, the
      “Determination Date”), the Conversion Price shall be adjusted by multiplying the Conversion
      Price in force immediately before such modifications by the following fraction:

                                             A–B
                                              A

     Where:

     A     is the sum of the products of, in respect of each of the classes of Ordinary Shares in issue
           immediately prior to the Determination Date, (i) the number of Ordinary Shares of such
           class in issue on the Determination Date and (ii) the Current Market Price per Ordinary
           Share of such class on the Determination Date; and


                                              123
     B     is the difference between (i) the aggregate Fair Market Value of the securities subject to
           such modification determined as if the modification had occurred less the aggregate Fair
           Market Value of the securities subject to such modification determined as if the
           modification had not occurred, and (ii) the aggregate consideration receivable for such
           modification.

     Where (i) such modification is in respect of securities which by their terms of issues carry rights
     of conversion into, or exchange or subscription for, more than one class of Ordinary Shares and
     (ii) any such class of Ordinary Shares is the H Shares class, the date of modification of rights
     of conversion into, or exchange or subscription for H Shares shall be deemed to be the date of
     modification of all rights of conversion into, or exchange or subscription for Ordinary Shares for
     the purpose of these Conditions.

     Such adjustment shall become effective on the date of modification of the rights of conversion,
     exchange, subscription, purchase or acquisition attaching to such securities (or, if later, the first
     date on which the fraction above is capable of being determined in accordance with these
     Conditions).

5.2.9 Other Offers to Ordinary Shareholders: In respect of each class of Ordinary Shares, if and
      whenever the Issuer or any of its Subsidiaries or (at the direction or request of or pursuant to
      any arrangements with the Issuer or any of its Subsidiaries) any other company, person or entity
      issues, sells or distributes any securities in connection with an offer pursuant to which the
      Ordinary Shareholders of such class generally are entitled to participate in arrangements
      whereby such securities may be acquired by them (except where the Conversion Price falls to
      be adjusted under Condition 5.3.4, Condition 5.3.5, Condition 5.3.6 or Condition 5.3.7 (or,
      where applicable, would fall to be so adjusted if the relevant issue or grant was at less than 95
      per cent. of the Current Market Price per H Share on the relevant Determination Date)), the
      Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately
      before such issue by the following fraction:

                                               A–B
                                                A

     Where:

     A     is the sum of the products of, in respect of each of the classes of Ordinary Shares in issue
           immediately prior to the Determination Date, (i) the number of Ordinary Shares of such
           class in issue and (ii) the Current Market Price per Ordinary Share of such class on the date
           on which the terms of such issue, sale or distribution of securities are first publicly
           announced (for the purpose of this Condition 5.3.9, the “Determination Date”); and

     B     is the aggregate Fair Market Value of the portion of the aggregate rights attributable to the
           Ordinary Shares in respect of each such class of Ordinary Shares.

     Such adjustment shall become effective on the date of issue, sale or distribution of the securities
     or, if a record date is fixed therefor, immediately after such record date (or if later, the first date
     on which the fraction above is capable of being determined in accordance with these
     Conditions).

     For the purpose of the above, Fair Market Value shall (subject as provided in the definition of
     “Fair Market Value” (as defined in Condition 5.8)) be determined as at the Determination Date.




                                                124
      5.2.10 Other Events: If the Issuer determines, in its sole discretion following consultation with the
             Calculation Agent, that an adjustment should be made to the Conversion Price as a result of one
             or more events or circumstances not referred to in this Condition 5.3, the Issuer shall, at its own
             expense, consult an Independent Financial Advisor to determine as soon as practicable what
             adjustment (if any) to the Conversion Price is fair and reasonable to take account thereof, if the
             adjustment would result in a reduction in the Conversion Price, and the date on which such
             adjustment should take effect and upon such determination by the Independent Financial Advisor
             such adjustment (if any) shall be made and shall take effect in accordance with such
             determination.

      5.2.11 Further Classes of Ordinary Shares: In the event that the Issuer has more than two classes of
             Ordinary Shares outstanding at any time, the formulae set out in this Condition 5.3 shall be
             restated to take into account such further classes of Ordinary Shares so that “B1 + B 2” and “C1
             + C 2” shall become “B1 + B 2 + B 3” and “C 1 + C 2 + C 3” and “B 3” and “C3” shall have the same
             meaning as “B1” and “C1”, respectively, but by reference to a third class of Ordinary Shares and
             so on.

      5.2.12 Modifications: Where the events or circumstances giving rise to any adjustment pursuant to this
             Condition 5.3 have already resulted or will result in an adjustment to the Conversion Price or
             where the events or circumstances giving rise to any adjustment arise by virtue of events or
             circumstances which have already given rise or will give rise to an adjustment to the Conversion
             Price, such modification (if any) shall be made to the operation of the provisions of this
             Condition 5.3 as may be advised by the Independent Financial Advisor to be in its opinion
             appropriate to give the intended result.

5.3   Undertakings

      5.3.1 The Issuer has undertaken in the Trust Deed, inter alia, that so long as any Bond remains
            outstanding, save with the approval of an Extraordinary Resolution (as defined in the Trust
            Deed) of the Bondholders:

            (i)    it will use its all reasonable endeavors (a) to maintain a listing for the H Shares on the
                   Hong Kong Stock Exchange, (b) to obtain and maintain a listing for all the H Shares issued
                   on the exercise of the Conversion Rights attaching to the Bonds on the Hong Kong Stock
                   Exchange and (c) if the Issuer is unable to obtain or maintain such listing, to obtain and
                   maintain a listing for all the issued H Shares on such Alternative Stock Exchange as the
                   Issuer may from time to time determine, and will forthwith give notice to the Bondholders
                   in accordance with Condition 16 of the listing or delisting of the H Shares (as a class) by
                   any such stock exchange;

            (ii)   it will pay the expenses of the issue and delivery of, and all expenses of obtaining listing
                   for, H Shares arising on conversion of the Bonds (save for the Duties to be borne by any
                   Bondholder as described in Condition 5.2.2);

            (iii) it will not make any reduction of its registered share capital or any uncalled liability in
                  respect thereof or of any share premium account or capital redemption reserve fund
                  (except, in each case, as permitted by law (including but not limited to repurchase or
                  cancellation of its shares (i) pursuant to any share incentive or share option schemes of the
                  Issuer; (ii) as a result of its shareholders’ dissent to the Issuer’s merger or segregation in
                  a shareholders’ meeting and request the Issuer to repurchase its shares; (iii) for the
                  protection of the interests of the Issuer’s shareholders; and (iv) as permitted by laws and
                  regulations and the Issuer’s articles of association) provided that the reduction results in
                  an adjustment to the Conversion Price then in effect); and


                                                         125
            (iv) it will use all reasonable endeavors to maintain the listing of the Bonds on the Hong Kong
                 Stock Exchange, and if the Issuer is unable to maintain such listing or such listing is
                 unduly onerous, to use all reasonable endeavours to obtain and maintain a listing on
                 another internationally recognised stock exchange as the Issuer may from time to time
                 determine (with prior notification to the Trustee) and will forthwith give notice to the
                 Bondholders in accordance with Condition 16 of the listing or delisting of the Bonds by
                 any such stock exchange.

      5.3.2 In the Trust Deed, the Issuer has undertaken with the Trustee that so long as any Bond remains
            outstanding, save with the approval of an Extraordinary Resolution of the Bondholders:

            (i)    it will issue H Shares to Bondholders on exercise of Conversion Rights and ensure that at
                   all times it has the ability to issue free from pre-emptive or other similar rights such
                   number of H Shares as would enable the Conversion Rights and all other rights of
                   subscription and exchange for and conversion into H Shares to be satisfied in full and will
                   ensure that all H Shares delivered upon conversion of the Bonds will be duly and validly
                   issued as fully-paid and not subject to call for further funds; and

            (ii)   it will not make any offer, issue or distribution or take any action the effect of which would
                   be to reduce the Conversion Price below the par value of the H Shares of the Issuer
                   provided always that the Issuer shall not be prohibited from purchasing its H Shares to the
                   extent permitted by law.

      5.3.3 The Issuer has also given certain other undertakings in the Trust Deed for the protection of the
            Conversion Rights.

5.4   Notice of Change in Conversion Price

      The Issuer shall give notice to the Hong Kong Stock Exchange, to the Trustee and each Conversion
      Agent in writing and to the Bondholders in accordance with Condition 16 of any change in the
      Conversion Price. Any such notice relating to a change in the Conversion Price shall set forth the event
      giving rise to the adjustment, the Conversion Price prior to such adjustment, the adjusted Conversion
      Price and the effective date of such adjustment.

5.5   Change of Control Conversion Price

      If a Change of Control (as defined in Condition 7.5.5) shall have occurred, the Issuer shall give notice
      of that fact to the Bondholders pursuant to Condition 7.5.4 (the “Change of Control Notice”).

      Following the giving of a Change of Control Notice, upon any exercise of Conversion Rights such that
      the relevant Conversion Date falls within the period of 30 days following the later of (i) the relevant
      Change of Control and (ii) the date on which the Change of Control Notice is given to Bondholders
      (such period, the “Change of Control Conversion Period”), the Conversion Price (the “Change of
      Control Conversion Price”) applicable solely for the purpose of such exercise of Conversion Rights,
      shall be the Conversion Price in effect on the Conversion Date adjusted in accordance with the
      following formula:

                                         NCP = OCP/(1 + (CP x c/t))

      Where:
      NCP          =     the Change of Control Conversion Price;

      OCP          =     the Conversion Price in effect on the relevant Conversion Date;

      CP           =     35.0 per cent. expressed as a fraction;

      c            =     the number of days from and including the date on which the Change of Control
                         has occurred; and

      t            =     the number of days from and including the Issue Date to but excluding the
                         Maturity Date,


                                                       126
      provided that if the Change of Control Conversion Price determined pursuant to this Condition 5.6
      would (but for the operation of this proviso) otherwise be below the level permitted by applicable laws
      and regulations from time to time (if any), it shall instead be equal to such level as aforesaid.

      If the last day of a Change of Control Conversion Period shall fall during a Restricted Transfer Period
      or a Restricted Conversion Period, as the case may be, the Change of Control Conversion Period shall
      be extended such that its last day will be the fifteenth day following the last day of the Restricted
      Transfer Period or the Restricted Conversion Period, as the case may be.

5.6   Provisions Relating to Changes in Conversion Price

      5.6.1 Minor Adjustments: On any adjustment, the resultant Conversion Price, if not an integral
            multiple of one Hong Kong cent, shall be rounded down to the nearest one Hong Kong cent. No
            adjustment shall be made to the Conversion Price if such adjustment (rounded down if
            applicable) would be less than one per cent. of the Conversion Price then in effect. Any
            adjustment not required to be made, and/or any amount by which the Conversion Price has been
            rounded down, shall be carried forward and taken into account in any subsequent adjustment,
            and such subsequent adjustment shall be made on the basis that the adjustment not required to
            be made had been made at the relevant time and/or, as the case may be, that the relevant rounding
            down had not been made. Notice of any adjustment shall be given by the Issuer to the
            Bondholders in accordance with Condition 16 and to the Trustee and the Agents in writing, in
            each case promptly after the determination thereof.

      5.6.2 Decision and Determination of the Calculation Agent or an Independent Financial Advisor:

           (a)   Adjustments to the Conversion Price shall be determined and calculated by the Calculation
                 Agent upon request from the Issuer and/or, to the extent so specified in the Conditions and
                 upon request from the Issuer, by an Independent Advisor.

                 Adjustments to the Conversion Price calculated by the Calculation Agent or, where
                 applicable, an Independent Advisor and any other determinations made by the Calculation
                 Agent or, where applicable, an Independent Advisor, or an opinion of an Independent
                 Advisor, pursuant to these Conditions shall in each case be made in good faith and shall
                 be final and binding (in the absence of manifest error) on the Issuer, the Trustee, the
                 Bondholders, the Calculation Agent (in the case of a determination by an Independent
                 Advisor) and the Agents.

           (b)   Subject as provided in the Calculation Agency Agreement, the Calculation Agent may
                 consult, at the expense of the Issuer, on any matter (including, but not limited to, any legal
                 matter), any legal or other professional adviser and it shall be able to rely upon, and it shall
                 not be liable and shall incur no liability as against the Trustee, the Bondholders or the
                 Agents in respect of anything done, or omitted to be done, relating to that matter in good
                 faith in accordance with that adviser’s opinion.

           (c)   The Calculation Agent shall act solely upon the request from, and exclusively as agent of,
                 the Issuer and in accordance with these Conditions. Neither the Calculation Agent (acting
                 in such capacity) nor any Independent Advisor appointed in connection with the Bonds
                 (acting in such capacity) will thereby assume any obligations towards or relationship of
                 agency or trust and shall not be liable and shall incur no liability in respect of anything
                 done, or omitted to be done in good faith, in its capacity as Calculation Agent as against
                 the Trustee, the Bondholders or the Agents.

           (d)   If, following consultation between the Issuer and the Calculation Agent, any doubt shall
                 arise as to an adjustment to the Conversion Price under Condition 5.3 or Condition 5.6, a
                 written opinion of such Independent Financial Advisor in respect thereof shall be
                 conclusive and binding on the Issuer, the Calculation Agent, the Bondholders and the
                 Trustee, save in the case of manifest error.


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5.6.3 Minimum Conversion Price: Notwithstanding the provisions of this Condition 5, the Issuer
      undertakes that: (i) the Conversion Price shall not in any event be reduced to below the nominal
      or par value of the H Shares as a result of any adjustment hereunder unless under applicable law
      then in effect the Bonds may be converted at such reduced Conversion Price into legally issued,
      fully paid and non-assessable H Shares; and (ii) it shall not take any action, and shall procure
      that no action is taken, that would otherwise result in an adjustment to the Conversion Price to
      below such nominal or par value or any minimum level permitted by applicable laws or
      regulations.

5.6.4 Multiple Events: Where more than one event which gives or may give rise to an adjustment to
      the Conversion Price occurs within such a short period of time that, in the opinion of an
      Independent Financial Advisor, the foregoing provisions would need to be operated subject to
      some modification in order to give the intended result, such modification shall be made to the
      operation of the foregoing provisions as may be advised by such Independent Financial Advisor
      to be in its opinion appropriate in order to give such intended result.

5.6.5 Upward/Downward Adjustment: No adjustment involving an increase in the Conversion Price
      will be made, except in the case of a consolidation, subdivision or re-classification of the H
      Shares as referred to in Condition 5.3.1 The Issuer may at any time and for a specified period
      of time only, following notice being given to the Trustee in writing and to the Bondholders in
      accordance with Condition 16, reduce the Conversion Price, subject to Condition 5.7.3.

5.6.6 Trustee Not Obliged to Monitor or Make Calculations: Neither the Trustee nor any Agent shall
      be under any duty to monitor whether any event or circumstance has happened or exists which
      may require an adjustment to be made to the Conversion Price or to make any calculation or
      determination (or verification thereof) in connection with the Conversion Price and none of them
      will be responsible or liable to Bondholders or any other person for any loss arising from any
      failure by it to do so or for any delay by the Issuer or any Independent Financial Advisor in
      making any calculation or determination or any erroneous calculation or determination in
      connection with the Conversion Price.

5.6.7 Employee Share Option Schemes: No adjustment will be made to the Conversion Price when
      Ordinary Shares or other securities (including rights or options) are issued, offered, exercised,
      allotted, appropriated, modified or granted to, or for the benefit of, employees (including
      directors) of the Issuer or any of its Subsidiaries pursuant to any employee share scheme or plan
      (and which employee share scheme or plan is in compliance with, if applicable, the Rules
      Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited or, if
      applicable, the Stock Listing Rules of the Shenzhen Stock Exchange or, if relevant, the listing
      rules of the Alternative Stock Exchange) (“Share Scheme Options”) unless any such issue or
      grant of Share Scheme Options (which, but for this provision, would have required adjustment
      pursuant to Condition 5) would result in the total number of Ordinary Shares which may be
      issued upon exercise of all Share Scheme Options granted during the 12-month period up to and
      including the date of such issue or grant representing, in aggregate, more than 2 per cent. of the
      average of the issued and outstanding Ordinary Shares during such 12-month period. For the
      avoidance of doubt, any Ordinary Shares issued in excess thereof, and only such Ordinary Shares
      issued in excess thereof, shall be subject to adjustment to the Conversion Price and taken into
      account in determining such adjustment as set out in Condition 5.3.

5.6.8 Consideration Receivable: For the purpose of any calculation of the consideration receivable or
      price pursuant to Condition 5.3.4, Condition 5.3.6, Condition 5.3.7 and Condition 5.3.8, the
      following provisions shall apply:

     (i)   the aggregate consideration receivable or price for Ordinary Shares of a class issued for
           cash shall be the amount of such cash;


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            (ii)   (a) the aggregate consideration receivable for Ordinary Shares of a class to be issued on
                   the conversion, exercise or exchange of any options, warrants or other rights or securities
                   (or following any modification thereof) shall be deemed to be the consideration received
                   or receivable by the Issuer for any such options, warrants or other rights or securities (or
                   following any modification thereof); (b) the aggregate consideration receivable for
                   Ordinary Shares of a class to be issued on the exercise of rights of subscription attached
                   to any such securities (or following any modification thereof) shall be deemed to be that
                   part (which may be the whole) of the consideration received or receivable by the Issuer for
                   such securities (or following any modification thereof) which is attributed by the Issuer to
                   such rights of subscription or, if no part of such consideration is so attributed, to the Fair
                   Market Value of such rights of subscription as at the relevant Determination Date, plus in
                   the case of each of (a) and (b) above, the additional minimum consideration (if any) to be
                   received by the Issuer on the conversion, exercise or exchange of such options, warrants
                   or other rights or securities (or following any modification thereof), or on the exercise of
                   such rights of subscription; and (c) the consideration per Ordinary Share of a class
                   receivable by the Issuer on the conversion, exercise or exchange of, or on the exercise of
                   such rights of subscription attached to, such options, warrants or other rights or securities
                   (or following any modification thereof) shall be the aggregate consideration referred to in
                   (a) or (b) above (as the case may be) divided by the number of Ordinary Shares of such
                   class to be issued on such conversion or exchange or exercise at the initial conversion,
                   exchange or subscription price or rate;

            (iii) if the consideration or price determined pursuant to (i) or (ii) above of this Condition 5.7.8
                  (or any component thereof) shall be expressed in a currency other than HK dollars, it shall
                  be converted into HK dollars at the Prevailing Rate on the relevant Determination Date;

            (iv) in determining the consideration or price pursuant to the above, no deduction shall be made
                 for any commissions or fees (howsoever described) or any expenses paid or incurred for
                 any underwriting, placing or management of the issue of the relevant Ordinary Shares of
                 a class or securities or options, warrants or rights, or otherwise in connection therewith;

            (v)    the consideration or price shall be determined as provided above on the basis of the
                   consideration or price received, receivable, paid or payable, regardless of whether all or
                   part thereof is received, receivable, paid or payable by or to the Issuer or another entity;
                   and

            (vi) if as part of the same transaction, Ordinary Shares of a class shall be issued or issuable for
                 a consideration receivable in more than one or in different currencies then the
                 consideration receivable per Share shall be determined by dividing the aggregate
                 consideration (determined as aforesaid and converted if and to the extent not in HK dollars,
                 into HK dollars as aforesaid) by the aggregate number of Ordinary Shares so issued.

5.7   Definitions

      For the purposes of these Conditions:

      “Alternative Stock Exchange” means, at any time, in the case of the H Shares, if they are not at that
      time listed and traded on the Hong Kong Stock Exchange, the principal stock exchange or securities
      market on which such H Shares are then listed or quoted or dealt in;

      “Applicable Date” means, in the case of an adjustment to the Conversion Price pursuant to:

      (a)   Condition 5.3.1, the date on which the relevant consolidation, subdivision or re-classification
            takes effect;


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(b)   Condition 5.3.2, 5.3.3, 5.3.4, 5.3.5 or 5.3.9 in respect of any issue, distribution, grant or offer
      in respect of one or more classes of Ordinary Shares (including H Shares), (I) the relevant
      Ex-Date in respect thereof, if no such date is capable of being determined in accordance with
      (I), such other date as is determined to be appropriate by an Independent Financial Advisor;

(c)   Condition 5.3.2, 5.3.3, 5.3.4, 5.3.5 or 5.3.9 in respect of any issue, distribution, grant or offer
      in respect of any class of Ordinary Shares (other than H Shares), the date of first public
      announcement of the terms thereof; or

(d)   Condition 5.3.6, 5.3.7 or 5.3.8, the relevant Determination Date as is mentioned in Condition
      5.3.6, 5.3.7 or 5.3.8, as the case may be.

“Applicable RA Date” means, in the case of an adjustment to the Conversion Price pursuant to:

(e)   Condition 5.3.1, the record date or other due date for the establishment of entitlement in respect
      of the relevant consolidation, subdivision or re-classification;

(f)   Condition 5.3.2, 5.3.3, 5.3.4, 5.3.5 or 5.3.9 in respect of any issue, distribution, grant or offer
      in respect of one or more classes of Ordinary Shares (including H Shares), (I) the record date
      or other due date for the establishment of entitlement in respect thereof or (II) if no such date
      is capable of being determined in accordance with (I), the date of first public announcement of
      such issue, distribution, grant or offer;

(g)   Condition 5.3.2, 5.3.3, 5.3.4, 5.3.5 or 5.3.9 in respect of any issue, distribution, grant or offer
      in respect of one or more classes of Ordinary Shares (other than H Shares), the date of first
      public announcement of such issue, distribution, grant or offer; or

(h)   Condition 5.3.6, 5.3.7 or 5.3.8, the relevant Determination Date as is mentioned in Condition
      5.3.6, 5.3.7 or 5.3.8, as the case may be.

“Closing Price” means, in respect of an Ordinary Share of any class or any other asset, option,
warrant or other right or other security, on any day, the official closing market price on the Relevant
Stock Exchange in respect thereof published by or derived from Bloomberg page HP (or any successor
ticker page) (setting ‘Official Closing Price’, or any other successor setting) in respect of such
Ordinary Share, or other asset, option, warrant or other right or other security (all as determined by
the Calculation Agent) (and for the avoidance of doubt such Bloomberg page is, as at the Issue Date,
(i) for the H Shares, 3759 HK Equity HP and (ii) for the A Shares, 300759 CH Equity HP), if available
or, in any other case, such other source (if any) as shall be determined in good faith to be appropriate
by an Independent Financial Advisor on such day, provided that:

(a)   if on any such day (for the purpose of this definition, the “Original Date”) such price is not
      available or cannot otherwise be determined as provided above, the Closing Price of an Ordinary
      Share, or other asset, option, warrant or other right or other security, in respect of such day shall
      be the Closing Price, determined by the Calculation Agent as provided above, on the
      immediately preceding Trading Day in respect thereof on which the same can be so determined,
      provided however that if such immediately preceding Trading Day falls prior to the seventh day
      before the Original Date, the Closing Price shall be considered to be not capable of being
      determined pursuant to this proviso (a); and

(b)   if the Closing Price cannot be determined as aforesaid, the Closing Price shall be determined as
      at the Original Date by an Independent Financial Advisor in such manner as it shall determine
      to be appropriate;


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“Current Market Price” means, in respect of an Ordinary Share of a class on a particular date, the
average of the daily Closing Price on each of the 10 consecutive Trading Days ending on and including
the Trading Day immediately preceding such date and (if necessary) translated into HK dollars at the
Prevailing Rate as at the relevant date; provided that, if at any time during such 10 Trading Day period
the Closing Price shall have been based on a price ex-dividend (or ex-any other entitlement) and
during some other part of that period the Closing Price shall have been based on a price cum-dividend
(or cum-any other entitlement), then:

(i)    if the Ordinary Shares of such class to be issued or transferred and delivered do not rank for the
       dividend (or entitlement) in question, the Closing Price on the dates on which the Ordinary
       Shares of such class shall have been based on a price cum-dividend (or cum-any other
       entitlement) shall for the purpose of this definition be deemed to be the amount thereof reduced
       by an amount equal to the Fair Market Value of any such dividend or entitlement per Ordinary
       Shares of such class; or

(ii)   if the Ordinary Shares of such class to be issued or transferred and delivered rank for the
       dividend or entitlement in question, the Closing Price on the dates on which the Ordinary Shares
       of such class shall have been based on a price ex-dividend (or ex-any other entitlement) shall
       for the purpose of this definition be deemed to be the amount thereof increased by the Fair
       Market Value of any such dividend or entitlement per Ordinary Shares of such class, and
       provided that, if on each of the said 10 Trading Days the Closing Price shall have been based
       on a price cum-dividend (or cum-any other entitlement) in respect of a dividend (or other
       entitlement) which has been declared or announced but the Ordinary Shares of such class to be
       issued or transferred and delivered do not rank for that dividend (or other entitlement), the
       Closing Price on each of such dates shall for the purposes of this definition be deemed to be the
       amount thereof reduced by an amount equal to the Fair Market Value of any such dividend or
       entitlement per Ordinary Shares of such class;

“Capital Distribution” means, on a per Ordinary Share basis, (i) any distribution of assets in specie
to the holders of such Ordinary Shares by the Issuer for any financial period whenever paid or made
and however described (and for these purposes a distribution of assets in specie includes, without
limitation, an issue of Ordinary Shares or other securities credited as fully or partly paid (other than
an issue of Ordinary Shares in the circumstances set out in Condition 5.3.1, or Condition 5.3.2(i)) by
way of capitalization of reserves, but excludes a Scrip Dividend adjusted for under Condition
5.3.2(ii)); and (ii) any cash dividend or distribution on a gross basis (including, without limitation, the
relevant cash amount of a Scrip Dividend) of any kind to the holders of such Ordinary Shares by the
Issuer for any financial period (whenever paid and however described), and shall include a purchase
or redemption of Ordinary Shares by or on behalf of the Issuer (except a purchase or redemption of
Ordinary Shares by or on behalf of the Issuer (or a purchase of Ordinary Shares by or on behalf of
a Subsidiary of the Issuer), where the weighted average price (before expenses) on any one day in
respect of such purchases does not exceed the Current Market Price of the Ordinary Shares by more
than five per cent. either (a) on that date, or (b) where an announcement has been made of the intention
to purchase Ordinary Shares at some future date at a specified price, on the Trading Day immediately
preceding the date of such announcement and, if in the case of either (a) or (b) of this definition, the
relevant day is not a Trading Day, the immediately preceding Trading Day) in an amount to be
determined by an Independent Financial Advisor;

“Ex-Date” means, in relation to any Capital Distribution, capitalisation, consolidation,
reclassification, redesignation or subdivision, issue, grant, offer or other entitlement, in each case in
respect of the H Shares, the first Trading Day for the H Shares on which the H Shares are traded ex-
the relevant Capital Distribution, capitalisation, consolidation, reclassification, redesignation or
subdivision, issue, grant, offer or other entitlement.



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“Fair Market Value” means, with respect to any asset, security, option, warrant or other right on any
date (for the purpose of this definition, the “FMV Date”):

(a)   (other than where paragraph (b), (c) or (d) below applies) in the case of any asset, security,
      option, warrant or other right, the fair market value thereof on such FMV Date as determined by
      an Independent Financial Advisor on the basis of commonly accepted market valuation method
      and taking into account such factors as it considers appropriate;

(b)   in the case of any cash Capital Distribution, the amount of such cash Capital Distribution, as
      determined by the Calculation Agent,

(c)   in the case of any other cash amount, the amount of such cash, as determined by the Calculation
      Agent;

(d)   in the case of any assets, options, warrants or other rights or other securities (including any class
      of Ordinary Shares) that are or will upon issuance be publicly traded on a Relevant Stock
      Exchange of adequate liquidity (as determined by an Independent Financial Advisor (or, if the
      Calculation Agent determines in its sole discretion it is capable of making such determination
      in its capacity as Calculation Agent, the Calculation Agent)), the arithmetic mean of the daily
      Closing Prices of such assets, options, warrants or other rights or securities during the period of
      five Trading Days for such assets, options, warrants or other rights or securities commencing on
      such FMV Date (or, if later, the date (for the purpose of this definition, the “Adjusted FMV
      Date”) which falls on the first such Trading Day such assets, options, warrants or other rights
      or securities are publicly traded, provided that provided that where such Adjusted FMV Date
      falls after the seventh day following the FMV Date, the Fair Market Value of such assets,
      options, warrants or other rights or securities shall instead be determined pursuant to paragraph
      (a) above, and no such Adjusted FMV Date shall be deemed to apply),

and provided that such amounts, if not expressed in HK dollars shall be translated into HK dollars at
the Prevailing Rate on such FMV Date (or, as the case may be, the Adjusted FMV Date), all as
determined by the Calculation Agent. In addition, in the case of paragraphs (b) and (c) above, the Fair
Market Value shall be determined by the Calculation Agent on a gross basis and disregarding any
withholding or deduction required to be made for or on account of tax and disregarding any associated
tax credit;

“Hong Kong Stock Exchange” means The Stock Exchange of Hong Kong Limited or any successor
thereto;

“H Share Stock Exchange Business Day” means any day (other than a Saturday or Sunday) on which
the Hong Kong Stock Exchange or the Alternative Stock Exchange (as the case may be) is open for
the business of dealing in securities;

“Independent Financial Advisor” means an independent investment bank or licensed financial
advisor or institution of international repute (acting as an expert) (which may include the Calculation
Agent) selected and appointed at its own cost by the Issuer and notified in writing to the Trustee. The
Trustee shall not be responsible for or under any obligation to appoint an Independent Financial
Advisor and shall have no responsibility or liability for verifying any calculation, determination,
certification, advice or opinion made, given or reached by it;

“Prevailing Rate” means, in respect of any currency on any day, the spot mid-rate of exchange
between the relevant currencies prevailing as at 12:00 noon (Hong Kong time) on that date as
appearing on or derived from the Relevant Page or, if such a rate cannot be determined at such time,
the rate prevailing as at 12:00 noon (Hong Kong time) on the immediately preceding day on which
such rate can be so determined, provided that in the case of any cash Capital Distribution in respect
of the H Shares, the “Prevailing Rate” shall be deemed to be the average benchmark exchange rate


                                                132
between Renminbi and HK dollars, calculated in the manner as announced by the Issuer on the Hong
Kong Stock Exchange from time to time, being as at the Issue Date the average of the medium rate
of Renminbi to HK dollars as announced by the People’s Bank of China for five working days
preceding (and including) the date on which such cash Capital Distribution are declared at the relevant
annual general meeting;

“Reference Date” means, in respect of any Retroactive Adjustment, the date on which the relevant
adjustment to the Conversion Price becomes effective under Condition 5.3 (notwithstanding, as the
case may be, that the date upon which it becomes effective falls after the end of the Conversion
Period).

“Reference H Shares” means, in respect of any exercise of Conversion Rights, the number of H
Shares that would be deliverable by the Issuer in respect thereof in accordance with these Conditions
(disregarding for this purpose any Additional H Shares).

“Relevant Cash Dividend” means the aggregate cash dividend or distribution declared by the Issuer,
including any cash dividend in respect of which there is any Scrip Dividend;

“Relevant Page” means the relevant Bloomberg BFIX page (or its successor page) or, if there is no
such page, such other Bloomberg page (as determined by the Calculation Agent) displaying the
relevant information, or, if there is no such page, from such other information service provider (as
determined to be appropriate by an Independent Financial Advisor) that displays the relevant
information;

“Relevant Stock Exchange” means:

(a)   in respect of the H Shares, the Hong Kong Stock Exchange (or any successor thereto) or, if at
      the relevant time the H Shares are not at that time listed and admitted to trading on the Hong
      Kong Stock Exchange, the Alternative Stock Exchange (if any);

(b)   in respect of the A Shares, the Shenzhen Stock Exchange (or any successor thereto) or, if at the
      relevant time the A Shares are not at that time listed and admitted to trading on the Shenzhen
      Stock Exchange, the principal stock exchange or securities market (if any) on which such A
      Shares are then listed and traded; and

(c)   in respect of any assets, options, warrants or other rights or other securities (other than the H
      Shares or the A Shares), the principal stock exchange or securities market (if any) on which such
      assets, options, warrants or other rights or other securities are then listed and traded,

where “principal stock exchange or securities market” shall mean the stock exchange or securities
market on which the A Shares, or, as the case may be, such other assets, options, warrants or other
rights or other securities are listed and traded, provided that if the A Shares, or, as the case may be,
such other assets, options, warrants or other rights or other securities are listed and traded on more
than one stock exchange or securities market at the relevant time, then “principal stock exchange or
securities market” shall mean that stock exchange or securities market on which the A Shares, or, as
the case may be, such other assets, options, warrants or other rights or other securities are then listed
and traded as determined by the Calculation Agent (if the Calculation Agent determines that it is able
to make such determination) or (in any other case) by an Independent Financial Advisor by reference
to the stock exchange or securities market with the highest average daily trading volume in respect
of the A Shares, or, as the case may be, such other assets, options, warrants or other rights or other
securities.

“Scrip Dividend” means Ordinary Shares of any class issued in lieu of the whole or any part of any
Relevant Cash Dividend being a dividend which the Ordinary Shareholders concerned would or could
otherwise have received;


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      “Shenzhen Stock Exchange” means The Shenzhen Stock Exchange;

      “Trading Day” means in respect of an Ordinary Share of any class, or other asset, option, warrant or
      other right or other security, a day on which (i) the Relevant Stock Exchange in respect thereof is open
      for dealing business and (ii) the Closing Price in respect thereof is capable of being determined
      (disregarding for this purpose the provisos to the definition of “Closing Price”); and

      “Volume Weighted Average Price” means, in respect of an Ordinary Share of any class or any other
      asset, option, warrant or other right or other security, on any day, the volume weighted average price
      on the Relevant Stock Exchange in respect thereof published by or derived from Bloomberg page HP
      (or any successor ticker page) (setting ‘Weighted Average Line’, or any other successor setting) in
      respect of such Ordinary Share, or other asset, option, warrant or other right or other security (all as
      determined by the Calculation Agent) (and for the avoidance of doubt such Bloomberg page is, as at
      the Issue Date, (i) for the H Shares, 3759 HK Equity HP and (ii) for the A Shares, 300759 CH Equity
      HP), if available or, in any other case, such other source (if any) as shall be determined in good faith
      to be appropriate by an Independent Financial Advisor on such day, provided that:

      (a)   if on any such day (for the purpose of this definition, the “Original Date”) such price is not
            available or cannot otherwise be determined as provided above, the Volume Weighted Average
            Price of an Ordinary Share, or other asset, option, warrant or other right or other security, in
            respect of such day shall be the Volume Weighted Average Price, determined by the Calculation
            Agent as provided above, on the immediately preceding Trading Day in respect thereof on which
            the same can be so determined, provided however that if such immediately preceding Trading
            Day falls prior to the seventh day before the Original Date, the Volume Weighted Average Price
            shall be considered to be not capable of being determined pursuant to this proviso (a); and

      (b)   if the Volume Weighted Average Price cannot be determined as aforesaid, the Volume Weighted
            Average Price shall be determined as at the Original Date by an Independent Financial Advisor
            in such manner as it shall determine to be appropriate.

            References to any issue or offer or grant to Ordinary Shareholders “as a class” or “by way of
            rights” shall be taken to be references to an issue or offer or grant to all or substantially all
            Ordinary Shareholders, other than Ordinary Shareholders by reason of the laws of any territory
            or requirements of any recognized regulatory body or any other stock exchange or securities
            market in any territory or in connection with fractional entitlements, it is determined not to make
            such issue or offer or grant.

6.    Payments

6.1   U.S. Dollar Settlement

      All amounts due under, and all claims arising out of or pursuant to, the Bonds and/or the Trust Deed
      from or against the Issuer shall be payable and settled in U.S. dollars only.

      For the purposes of these Conditions, “U.S. Dollar Equivalent” means, in respect of a Renminbi-
      denominated amount that, but for this Condition 6.1, would be due under the Bonds in Renminbi, the
      Renminbi amount converted into U.S. dollars using the Spot Rate for the relevant Rate Calculation
      Date (as defined below) as determined by the Calculation Agent.

      For the purpose of this Condition 6.1:

      “Business Day” means a day (other than a Saturday or a Sunday or a public holiday) on which banks
      are open for business in Hong Kong, Beijing, London and New York;

      “Rate Calculation Date” means the day which is two Business Days before the due date of the
      relevant amount under these Conditions;


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      “Reference Dealers” means four leading dealers engaged in the foreign exchange market of the
      relevant currency selected by the Issuer;

      “Spot Rate” means, for each Rate Calculation Date, a rate determined by the Calculation Agent as
      follows:

      (a)   in respect of the US dollar and Renminbi, the USD/CNY(HK) Spot Rate, expressed as the
            amount of Renminbi per one US dollar, reported by the Hong Kong Treasury Markets
            Association, which appears on the Bloomberg page “CNH TMAF Currency HP” at
            approximately 11:30 a.m. (Hong Kong time) on the Rate Calculation Date, or any such other
            source as the Calculation Agent may determine which displays such rate;

      (b)   if no such rate is available under sub-paragraphs (a) of this definition, the spot rate determined
            by the Calculation Agent on the basis of quotations provided by the Reference Dealers of the
            specified exchange rate for the Rate Calculation Date as obtained in accordance with the
            provisions below, or if fewer than two quotations are provided, the exchange rate for the Rate
            Calculation Date as shall be determined by an Independent Financial Advisor in good faith.

      In determining the Spot Rate under sub-paragraph (b) of this definition, the Issuer will request the
      Hong Kong office of each of the Reference Dealers to provide a quotation of what the specified screen
      rate would have been had it been published, reported or available for the Rate Calculation Date, based
      upon each Reference Dealer’s experience in the foreign exchange market for Renminbi and general
      activity in such market on the Rate Calculation Date. The quotations used to determine the Spot Rate
      under sub-paragraph (c) of this definition for a Rate Calculation Date will be determined in each case
      for such Rate Calculation Date, and will be requested on such Rate Calculation Date or as soon as
      practicable after it is determined that the specified screen rate was not available.

      If four quotations are provided, the rate for a Rate Calculation Date will be the arithmetic mean of the
      rates, without regard to the rates having the highest and lowest value. For this purpose, if more than
      one quotation has the same highest value or lowest value, then the rate of only one of such quotations
      shall be disregarded. If two or three quotations are provided, the rate for a Rate Calculation Date will
      be the arithmetic mean of the rates provided.

      All notifications, opinions, determinations, certificates, calculations, quotations and decisions given,
      expressed, made or obtained for the purposes of the provisions of this Condition 7, whether by the
      Reference Dealers (or any of them), the Calculation Agent or the Independent Financial Advisor, will
      be binding on the Issuer, the Trustee, the Agents and the Bondholders, save in the case of manifest
      error.

      With respect to each Spot Rate determined by the Calculation Agent under the definition of “Spot
      Rate”, the Calculation Agent shall inform the Issuer of such Spot Rate and the US Dollar Equivalent
      of the relevant amount no later than 5:00 p.m. (Hong Kong time) on the Rate Calculation Date after
      the Spot Rate has been determined.

6.2   Principal

      Payment of principal, premium and interest (if any) will be made by transfer to the registered account
      of the Bondholder except in the case of any amount payable by the Issuer pursuant to Condition 5,
      where any amounts payable to a Bondholder will be made by U.S. dollar cheque drawn on a bank that
      processes payments in U.S. dollars and mailed to the address of the Bondholder or by transfer to a U.S.
      dollar account maintained by the payee, in either case in accordance with instructions given by the
      relevant Bondholder in the Conversion Notice. Such payment of principal will only be made after
      surrender of the relevant Certificate at the specified office of any of the Agents.

      If an amount which is due on the Bonds is not paid in full, the Registrar will annotate the Register
      with a record of the amount (if any) in fact paid.


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      References in these Conditions, the Trust Deed and the Agency Agreement to principal in respect of
      any Bond shall, where the context so permits, be deemed to include a reference to any premium
      payable thereon.

      So long as the Bonds are represented by the Global Certificate and the Global Certificate is held on
      behalf of Euroclear or Clearstream (each, a “relevant clearing system”), each payment in respect of
      the Global Certificate will be made to the person shown as the holder thereof in the Register at the
      close of business (in the relevant clearing system) on the Clearing System Business Day before the due
      date for such payment, where “Clearing System Business Day” means a weekday (Monday to Friday,
      inclusive) except December 25 and January 1.

6.3   Registered Accounts

      For the purposes of this Condition 6, a Bondholder’s registered account means the U.S. dollar account
      maintained by or on behalf of it with a bank that processes payments in U.S. dollars, details of which
      appear on the Register at the close of business on the second Payment Business Day (as defined in
      Condition 6.7) before the due date for payment, and a Bondholder’s registered address means its
      address appearing on the Register at that time.

6.4   Fiscal Laws

      All payments are subject in all cases to (i) any applicable fiscal or other laws and regulations in the
      place of payment, but without prejudice to the provisions of Condition 8 and (ii) any withholding or
      deduction required pursuant to an agreement described in Section 147 1(b) of the U.S. Internal
      Revenue Code of 1986, as amended (the “Code”) or otherwise imposed pursuant to Sections 1471
      through 1474 of the Code, any regulations or agreements thereunder, any official interpretations
      thereof, or (without prejudice to the provisions of Condition 8) any law implementing an
      intergovernmental approach thereto. No commissions or expenses shall be charged to the Bondholders
      in respect of such payments.

6.5   Payment Initiation

      Payment instructions (for value on the due date or, if that is not a Payment Business Day, for value
      on the first following day which is a Payment Business Day) will be initiated on the due date for
      payment (or, if it is not a Payment Business Day, the immediately following Payment Business Day)
      or, in the case of a payment of principal, if later, on the Payment Business Day on which the relevant
      Certificate is surrendered at the specified office of an Agent.

6.6   Delay in Payment

      Bondholders will not be entitled to any interest (if any) or other payment for any delay after the due
      date in receiving the amount due if the due date is not a Business Day or if the Bondholder is late in
      surrendering its Certificate (if required to do so).

6.7   Payment Business Day

      In this Condition 6, “Payment Business Day” means a day other than a Saturday or Sunday on which
      commercial banks and foreign exchange markets are open for business in New York City and the city
      in which the specified office of the Principal Agent is located and, in the case of the surrender of a
      Certificate, in the place where the Certificate is surrendered.




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6.8   Appointment of Agents

      The initial Agents and their initial specified offices are listed below. The Issuer reserves the right at
      any time, with the prior written approval of the Trustee, to vary or terminate the appointment of any
      Agent and appoint additional or replacement Agents provided that the Issuer shall at all times maintain
      (i) a Principal Agent, (ii) a Registrar, (iii) a Transfer Agent, (iv) a Conversion Agent and (v) such other
      agents as may be required by the stock exchange on which the Bonds may be listed, in each case, as
      approved in writing by the Trustee. The Issuer reserves the right at any time, with the prior written
      approval of the Trustee, to vary or terminate the appointment of the Calculation Agent and appoint
      another Calculation Agent provided that the Issuer shall at all times maintain a Calculation Agent
      which shall be a financial institution of international repute or a financial adviser with appropriate
      expertise.

      Notice of any changes in any Agent, their specified offices or the Calculation Agent will promptly be
      given by the Issuer to the Bondholders in accordance with Condition 16.

7.    Redemption, Purchase and Cancellation

      For the purposes of this Condition 7:

      “Early Redemption Amount” means, in respect of any date, an amount equal to:

                                              Previous Redemption Amount x (1 + r/2)d/p,

      Where

      Previous Redemption Amount = the Early Redemption Amount for each RMB1,000,000 principal
      amount on the Semi-annual Date immediately preceding the date fixed for redemption as set out below
      (or if the Bonds are to be redeemed prior to December 18, 2021, RMB1,000,000):

                                                                                                                              Early Redemption
                                                                                                                                   Amount
                                                                                                                                   (RMB)
      Semi-annual Date
      December 18, 2021 ...............................................................................................          1,007,500.00
      June 18, 2022 .......................................................................................................      1,015,056.25
      December 18, 2022 ...............................................................................................          1,022,669.17
      June 18, 2023 .......................................................................................................      1,030,339.19
      December 18, 2023 ...............................................................................................          1,038,066.73
      June 18, 2024 .......................................................................................................      1,045,852.24
      December 18, 2024 ...............................................................................................          1,053,696.13
      June 18, 2025 .......................................................................................................      1,061,598.85
      December 18, 2025 ...............................................................................................          1,069,560.84

      r              =         1.50 per cent. expressed as a fraction;

      d              =         number of days from and including the immediately preceding Semi-annual Date
                               (or if the Bonds are to be redeemed on or before December 18, 2021, from and
                               including the Issue Date) to, but excluding, the date fixed for redemption,
                               calculated on the basis of a 360-day year consisting of 12 months of 30 days
                               each and, in the case of an incomplete month, the number of days elapsed;

      p              =         180.



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7.1   Maturity

      Unless previously redeemed, converted or purchased and cancelled as provided herein, the Issuer will
      redeem each Bond at the U.S. Dollar Equivalent of 107.76 per cent. of its outstanding principal
      amount on June 18, 2026 (the “Maturity Date”). The Issuer may not redeem the Bonds at its option
      prior to that date except as provided in Condition 7.2 or Condition 7.3 below (but without prejudice
      to Condition 9).

7.2   Redemption at the Option of the Issuer

      7.2.1 The Issuer may, having given not less than 30 nor more than 60 days’ notice (an “Optional
            Redemption Notice”) to the Bondholders, the Trustee and the Principal Agent (which notice will
            be irrevocable), redeem all but not some only of the Bonds for the time being outstanding at the
            U.S. Dollar Equivalent of the Early Redemption Amount as at the relevant redemption date if at
            any time the aggregate principal amount of the Bonds outstanding is less than 10 per cent. of the
            aggregate principal amount originally issued (including any Bonds issued pursuant to Condition
            15). Upon the expiry of the Optional Redemption Notice, the Issuer will be bound to redeem the
            relevant Bonds for the time being outstanding at the U.S. Dollar Equivalent of the Early
            Redemption Amount as at the date fixed for such redemption.

      7.2.2 The Trustee and the Agents shall have no obligation to confirm whether the circumstances giving
            rise to a right for the Issuer to redeem under this Condition 7.2 have in any case arisen.

7.3   Redemption for Taxation Reasons

      7.3.1 At any time the Issuer may, having given not less than 30 nor more than 60 days’ notice to the
            Trustee, the Principal Agent and the Bondholders (which notice shall be irrevocable) redeem all
            but not some only of the Bonds at the U.S. Dollar Equivalent of the Early Redemption Amount
            as at the relevant redemption date (the “Tax Redemption Date”), if the Issuer satisfies the
            Trustee immediately prior to the giving of such notice that (i) the Issuer has or will become
            obliged to pay Additional Tax Amounts as provided or referred to in Condition 8 as a result of
            any change in, or amendment to, the laws or regulations of the PRC or Hong Kong or, in each
            case, any political subdivision or any authority thereof or therein having power to tax, or any
            change in the general application or official interpretation of such laws or regulations, which
            change or amendment becomes effective on or after June 8, 2021, and (ii) such obligation cannot
            be avoided by the Issuer taking reasonable measures available to it, provided that no such notice
            of redemption shall be given earlier than 90 days prior to the earliest date on which the Issuer
            would be obliged to pay such Additional Tax Amounts were a payment in respect of the Bonds
            then due. Prior to the publication of any notice of redemption pursuant to this Condition 7.3.1,
            the Issuer shall deliver to the Trustee (a) a certificate signed by two directors of the Issuer, each
            of whom are also Authorised Signatories of the Issuer, stating that the obligation referred to in
            (i) above of this Condition 7.3.1 cannot be avoided by the Issuer having taken reasonable
            measures available to it and (b) an opinion of independent legal or tax advisors of recognized
            standing to the effect that such change or amendment has occurred (irrespective of whether such
            amendment or change is then effective), and the Trustee shall be entitled to accept such
            certificate and opinion as sufficient evidence thereof, in which event the same shall be
            conclusive and binding on the Bondholders.

      7.3.2 If the Issuer gives a notice of redemption pursuant to this Condition 7.3, each Bondholder will
            have the right to elect that his Bond(s) shall not be redeemed and that the provisions of
            Condition 8 shall not apply in respect of any payment of principal, or interest (if any) to be made
            in respect of such Bond(s) which falls due after the relevant Tax Redemption Date whereupon
            no Additional Tax Amounts shall be payable in respect thereof pursuant to Condition 8 and
            payment of all amounts shall be made subject to the deduction or withholding of the taxation
            required to be withheld or deducted by the government of the PRC or Hong Kong or, in each
            case, any authority thereof or therein having power to tax. For the avoidance of doubt, any


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           Additional Tax Amounts which had been payable in respect of the Bonds as a result of the laws
           or regulations of the government of the PRC or Hong Kong or, in each case, any authority
           thereof or therein having power to tax prior to June 8, 2021, will continue to be payable to such
           Bondholders. To exercise such right, the holder of the relevant Bond must complete, sign and
           deposit at the specified office of any Paying Agent during normal business hours (being between
           9.00 a.m. and 3.00 p.m.) a duly completed and signed notice of election, in the form for the time
           being current, obtainable from the specified office of any Paying Agent, together with the
           Certificate evidencing the Bonds on or before the day falling 10 days prior to the Tax
           Redemption Date. Such notice of election, once delivered, shall be irrevocable and may not be
           withdrawn without the Issuer’s consent.

7.4   Redemption at the Option of the Bondholders

      The holder of each Bond will have the right at such holder’s option, to require the Issuer to redeem
      all or some only of that holder’s Bonds on June 18, 2024 (the “Put Option Date”) at the U.S. Dollar
      Equivalent of 104.59 per cent. of their outstanding principal amount on the Put Option Date. To
      exercise such right, the holder of the relevant Bond must complete, sign and deposit at the specified
      office of any Paying Agent during normal business hours (being between 9.00 a.m. and 3.00 p.m.) a
      duly completed and signed notice (the “Put Option Notice”), substantially in the form scheduled to
      the Agency Agreement, obtainable from the specified office of any Paying Agent, together with the
      Certificate evidencing the Bonds to be redeemed not earlier than 60 days and not later than 30 days
      prior to the Put Option Date.

      A Put Option Notice, once delivered, shall be irrevocable (and may not be withdrawn unless the Issuer
      consents to such withdrawal) and the Issuer shall redeem the Bonds the subject of a Put Option Notice
      delivered as aforesaid on the Put Option Date.

7.5   Redemption for Relevant Events

      7.5.1 Following the occurrence of a Relevant Event (as defined in Condition 7.5.5), the holder of each
            Bond will have the right at such holder’s option, to require the Issuer to redeem all or some only
            such holder’s Bonds on the Relevant Event Put Date (as defined below) at the U.S. Dollar
            Equivalent of the Early Redemption amount as at the Relevant Event Put Date. To exercise such
            right, the holder of the relevant Bond must complete, sign and deposit at the specified office of
            any Paying Agent during normal business hours (being between 9.00 a.m. and 3.00 p.m.) a duly
            completed and signed notice of redemption, substantially in the form scheduled to the Agency
            Agreement, obtainable from the specified office of any Paying Agent (a “Relevant Event Put
            Exercise Notice”) together with the Certificate evidencing the Bonds to be redeemed by not later
            than 30 days following a Relevant Event, or, if later, 30 days following the date upon which
            notice thereof is given to Bondholders by the Issuer in accordance with Condition 16. The
            “Relevant Event Put Date” shall be the fourteenth day after the expiry of such period of 30 days
            as referred to above in this Condition 7.5.1.

      7.5.2 A Relevant Event Put Exercise Notice, once delivered, shall be irrevocable and may not be
            withdrawn without the Issuer’s consent. The Issuer shall redeem the Bonds which form the
            subject of the Relevant Event Put Exercise Notices delivered as aforesaid (subject to delivery of
            the relevant Certificates) on the Relevant Event Put Date.

      7.5.3 None of the Trustee or the Agents shall be required to monitor or take any steps to ascertain
            whether a Relevant Event or any event which could lead to the occurrence of a Relevant Event
            has occurred and shall not be liable to Bondholders or any other person for not doing so.




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7.5.4 Not later than seven days after becoming aware of a Relevant Event, the Issuer shall procure that
      notice regarding the Relevant Event shall be delivered to Bondholders (in accordance with
      Condition 16) and to the Trustee and the Principal Agent in writing stating:

           (i)    the Relevant Event Put Date;

           (ii)   the date of such Relevant Event and, briefly, the events causing such Relevant Event;

           (iii) the date by which the Relevant Event Put Exercise Notice must be given;

           (iv) the redemption amount and the method by which such amount will be paid;

           (v)    the names and addresses of all Paying Agents;

           (vi) briefly, the Conversion Right and the Conversion Price as at the last practicable date
                immediately prior to the date on which such notice is given (and, if the Relevant
                Event is a Change of Control, (i) the Change of Control Conversion Price, determined
                for the purpose of such notice, on the basis of such Conversion Price as at such last
                practicable date as aforesaid, and (ii) the Change of Control Conversion Period);

           (vii) the procedures that Bondholders must follow and the requirements that Bondholders
                 must satisfy in order to exercise their rights under this Condition 7.5 or their
                 Conversion Right; and

           (viii) that a Relevant Event Put Exercise Notice, once validly given, may not be withdrawn
                  without the Issuer’s consent.

7.5.5 For the purposes of this Condition 7.5:

     “Affiliated Holders” means, with respect to any specified natural person, any company,
     partnership, trust, foundation or other entity or investment vehicle for which such specified
     natural person retains sole voting and dispositive power with respect to the Ordinary Shares, as
     applicable, held by such company, partnership, trust, foundation or other entity or investment
     vehicle, and the trustees, legal representatives, beneficiaries and/or beneficial owners, but solely
     in such capacity, of such company, partnership, trust, foundation or other entity or investment
     vehicle;

     a “Change of Control” occurs when:

     (a)   the Founding Individuals, collectively, together with any voting rights controlled directly
           or indirectly by the Founding Individuals, including through any voting proxy arrangement
           and/or acting-in-concert agreement, ceases to be the single largest holder of voting rights
           in the Issuer;

     (b)   other than Founding Individuals, any person or persons, acting together, acquires control
           of the Issuer if such person or persons does not or do not have, and would not be deemed
           to have, control of the Issuer on the Issue Date;

     (c)   the Issuer consolidates with or merges into or sells or transfers all or substantially all of
           the Issuer’s assets to any other person, unless the consolidation, merger, sale or transfer
           will not result in an event specified in (b) above with respect to the Issuer or the successor
           entity; or

     (d)   one or more other persons acquires the legal or beneficial ownership of all or substantially
           all of the Issuer’s registered share capital;


                                                140
           “control” means the acquisition or control of more than 50 per cent. of the voting rights of the
           registered share capital of the Issuer or the right to appoint and/or remove all or the majority of
           the members of the Issuer’s board of directors or other governing body, whether obtained
           directly or indirectly, and whether obtained by ownership of share capital, the possession of
           voting rights, contract or otherwise;

           a “Delisting” occurs when the H Shares cease to be listed or admitted to trading on the Hong
           Kong Stock Exchange;

           “Founding Individuals” means (a) Dr. LOU Boliang (          ), Mr. LOU Xiaoqiang (           )
           and Ms ZHENG Bei (       ) and (b) each of the respective Affiliated Holders referred to in this
           Condition 7.5.5;

           a “H Share Suspension in Trading” means the suspension in trading of the H Shares for a
           period of 20 consecutive H Share Stock Exchange Business Days;

           a “person” includes any individual, company, corporation, firm, partnership, joint venture,
           undertaking, association, organization, trust, state or agency of a state (in each case whether or
           not being a separate legal entity) but does not include the Issuer’s board of directors or any other
           governing board and does not include the Issuer’s wholly-owned direct or indirect Subsidiaries;

           a “Relevant Event” means the occurrence of either (a) a Change of Control in the Issuer; (b)
           a Delisting or (c) a H Share Suspension in Trading; and

           “voting rights” means the right generally to vote at general meetings of shareholders of the
           Issuer (irrespective of whether or not, at the time, stock of any other class or classes shall have,
           or might have, voting power by reason of the happening of any contingency).

7.6   Purchases

      The Issuer or any of its Subsidiaries may, subject to applicable laws and regulations, at any time and
      from time to time purchase Bonds at any price in the open market or otherwise. The Bonds so
      acquired, while held by or on behalf of the Issuer or any such Subsidiary, shall not entitle them to
      convert the Bonds in accordance with these Conditions nor shall such Bonds be deemed to be
      outstanding for the purposes of, among other things, calculating quorums at meetings of the
      Bondholders and exercising any voting rights with respect to such Bonds and Conditions 9 and 13.

7.7   Cancellation

      All Bonds which are repurchased, redeemed or converted or purchased by or on behalf of the Issuer
      or any of its Subsidiaries will forthwith be cancelled. Certificates in respect of all Bonds cancelled
      will be forwarded to or to the order of the Registrar and such Bonds may not be reissued or resold.

7.8   Redemption Notices

      All notices to Bondholders given by or on behalf of the Issuer pursuant to this Condition 7 will be
      irrevocable and will be given in accordance with Condition 16 specifying: (i) the Conversion Price as
      at the date of the relevant notice; (ii) the last day on which Conversion Rights may be exercised; (iii)
      the Closing Price of the H Shares as at the latest practicable date prior to the publication of the notice,
      (iv) the date fixed for redemption; (v) the manner in which redemption will be effected; and (vi) the
      aggregate principal amount of the Bonds outstanding as at the latest practicable date prior to the
      publication of the notice.


                                                      141
      If more than one notice of redemption is given (being a notice given by either the Issuer or a
      Bondholder pursuant to these Conditions), the first in time shall prevail.

      Neither the Trustee nor any of the Agents shall be responsible for calculating or verifying the
      calculations of any amount payable on redemption of the Bonds pursuant to this Condition 7 and none
      of them shall be liable to the Bondholders or any other person for not doing so.

8.    Taxation

8.1   All payments made by or on behalf of the Issuer in respect of the Bonds will be made free from any
      restriction or condition and will be made without deduction or withholding for or on account of any
      present or future taxes, duties, assessments or governmental charges of whatever nature imposed,
      levied, collected, withheld or assessed by or on behalf of the PRC or Hong Kong or, in each case, any
      authority thereof or therein having power to tax, unless deduction or withholding of such taxes, duties,
      assessments or governmental charges is compelled by law. Where such withholding or deduction is
      made by the Issuer by or within the PRC up to and including the aggregate rate applicable on June 8,
      2021 (the “Applicable Rate”), the Issuer will increase the amounts paid by it to the extent required,
      so that the net amount received by Bondholders equals the amounts which would otherwise have been
      receivable by them had no such withholding or deduction been required. If the Issuer is required to
      make a deduction or withholding in respect of PRC tax in excess of the Applicable Rate, or any Hong
      Kong deduction or withholding is required, in such event the Issuer shall pay such additional amounts
      (“Additional Tax Amounts”) as will result in receipt by the Bondholders of such amounts as would
      have been received by them had no such withholding or deduction been required, except that no
      Additional Tax Amounts shall be payable in respect of any Bond:

      8.1.1 to a holder (or to a third party on behalf of a holder) who is subject to such taxes, duties,
            assessments or governmental charges in respect of such Bond by reason of his having some
            connection with the PRC or Hong Kong, as the case may be, otherwise than merely by holding
            the Bond or by the receipt of amounts in respect of the Bond or where the withholding or
            deduction could be avoided by the holder making a declaration of non-residence or other similar
            claim for exemption to the appropriate authority which such holder is legally capable and
            competent of making but fails to do so; or

      8.1.2 (in the case of a payment of principal) if the Certificate in respect of such Bond is surrendered
            more than 30 days after the Relevant Date except to the extent that the holder would have been
            entitled to such additional amount on surrendering the relevant Certificate for payment on the
            last day of such period of 30 days.

8.2   “Relevant Date” means whichever is the later of (i) the date on which such payment first becomes
      due and (ii) if the full amount payable has not been received by the Trustee or the Principal Agent on
      or prior to such due date, the date on which, the full amount having been so received, notice to that
      effect shall have been given to the Bondholders and payment made.

8.3   References in these Conditions to principal and interest (if any) shall be deemed also to refer to any
      additional amounts or premiums which may be payable under these Conditions or any undertaking or
      covenant given in addition thereto or in substitution therefor pursuant to the Trust Deed.

8.4   Neither the Trustee nor any Agent shall be responsible for paying any tax, duty, charges, withholding
      or other payment referred to in this Condition 8 or for determining whether such amounts are payable
      or the amount thereof, and none of them shall be responsible or liable for any failure by the Issuer,
      any Bondholder or any third party to pay such tax, duty, charges, withholding or other payment in any
      jurisdiction or to provide any notice or information to the Trustee or any Agent that would permit,
      enable or facilitate the payment of any principal, premium (if any), interest or other amount under or
      in respect of the Bonds without deduction or withholding for or on account of any tax, duty, charge,
      withholding or other payment imposed by or in any jurisdiction.


                                                     142
9.    Events of Default

      The Trustee at its discretion may, and if so requested in writing by the holders of not less than 25 per
      cent. in principal amount of the Bonds then outstanding or if so directed by an Extraordinary
      Resolution shall (subject in any such case to being indemnified and/or secured and/or pre-funded to
      its satisfaction), give notice to the Issuer that the Bonds are, and they shall accordingly thereby
      become, immediately due and repayable at the U.S. Dollar Equivalent of the Early Redemption
      Amount (subject as provided below and without prejudice to the right of Bondholders to exercise the
      Conversion Right in respect of their Bonds in accordance with Condition 5) if any of the following
      events (each an “Event of Default”) has occurred:

9.1   the Issuer fails to pay the principal and premium (if any) on any of the Bonds when due; or

9.2   failure by the Issuer to deliver the H Shares as and when such H Shares are required to be delivered
      following conversion of a Bond; or

9.3   the Issuer does not perform or comply with one or more of its other obligations in the Bonds or the
      Trust Deed which default is in the opinion of the Trustee incapable of remedy or, if capable of remedy
      in the opinion of the Trustee, is not remedied within 30 days after written notice of such default shall
      have been given to the Issuer by the Trustee; or

9.4   the Issuer or any Principal Subsidiary is (or is, or could be, deemed by law or a court to be) insolvent
      or bankrupt or unable to pay its debts, stops, suspends or threatens to stop or suspend payment of all
      or a material part of (or of a particular type of) its debts, proposes or makes any agreement for the
      deferral, rescheduling or other readjustment of all or a material part of (or of a particular type of) its
      debts, proposes or makes a general assignment or an arrangement or composition with or for the
      benefit of the relevant creditors in respect of any of such debts or a moratorium is agreed or declared
      in respect of or affecting all or any part of (or of a particular type of) the debts of the Issuer or any
      Principal Subsidiary; or

9.5   (i) any other present or future indebtedness of the Issuer or any of its Subsidiaries for or in respect
      of moneys borrowed or raised becomes (or becomes capable of being declared) due and payable prior
      to its stated maturity by reason of any actual or potential default, event of default or the like
      (howsoever described), or (ii) any such indebtedness is not paid when due or, as the case may be,
      within any applicable grace period, or (iii) the Issuer or any of its Subsidiaries fails to pay when due
      any amount payable by it under any present or future guarantee for, or indemnity in respect of, any
      present or future indebtedness in respect of moneys borrowed or raised, provided that the aggregate
      amount of the relevant indebtedness, guarantees and indemnities in respect of which one or more of
      the events mentioned above in this Condition 9.5 have occurred equals or exceeds U.S.$25,000,000
      or its equivalent in other currency or currencies (as determined on the basis of the middle spot rate
      for the relevant currency against the U.S. dollar as quoted by any leading bank on the day on which
      such indebtedness become due and payable or is not paid or any such amount become due and payable
      or is not paid under any such guarantee or indemnity); or

9.6   a distress, attachment, execution or other legal process is levied, enforced or sued out on or against
      any material part of the property, assets or revenues of the Issuer or any of its Principal Subsidiaries
      and is not discharged or stayed within 30 days; or

9.7   an order is made or an effective resolution passed for the winding-up or dissolution, judicial
      management or administration of the Issuer or any Principal Subsidiary, or the Issuer or any Principal
      Subsidiary ceases or threatens to cease to carry on all or any material part of its business or operations,
      except for the purpose of and followed by a reconstruction, amalgamation, reorganisation, merger or
      consolidation (i) on terms approved by an Extraordinary Resolution of the Bondholders, or (ii) in the
      case of a Principal Subsidiary, whereby the undertaking and assets of such Principal Subsidiary are
      transferred to or otherwise vested in the Issuer or another Principal Subsidiary; or


                                                      143
9.8   any mortgage, charge, pledge, lien or other encumbrance, present or future, created or assumed by the
      Issuer or any of its Subsidiaries on any material part of their respective property, assets or revenues
      becomes enforceable and any step is taken to enforce it (including the taking of possession or the
      appointment of a receiver, manager or other similar person) and is not discharged within 30 days; or

9.9   it is or will become unlawful for the Issuer to perform or comply with any one or more of its
      obligations under any of the Bonds or the Trust Deed; or

9.10 any action, condition or thing (including the obtaining or effecting of any necessary consent, approval,
     authorisation, exemption, filing, license, order, recording or registration) at any time required to be
     taken, fulfilled or done by the Issuer in order (i) to enable the Issuer lawfully to enter into, exercise
     its rights and perform and comply with its obligations under the Bonds and the Trust Deed, (ii) to
     ensure that those obligations are legally binding and enforceable and (iii) to make the Bonds and the
     Trust Deed admissible in evidence in the courts of the PRC or Hong Kong is not taken, fulfilled or
     done; or

9.11 any step is taken by any person with a view to the seizure, compulsory acquisition, expropriation or
     nationalisation of all or any material part of the assets of the Issuer or any Principal Subsidiary; or

9.12 the Trust Deed or any of the Bonds ceases for any reason (or is claimed by the Issuer not) to be the
     legal and valid obligations of the Issuer, binding upon it in accordance with its terms (subject to
     equitable principles and insolvency laws affecting creditors’ rights generally); or

9.13 any event occurs which under the laws of any relevant jurisdiction has an analogous effect to any of
     the events referred to in any of Conditions 9.6 to 9.8 (both inclusive) or Condition 9.10 or Condition
     9.11.

      The Trustee and the Agents shall not be bound to take any steps to ascertain whether any Event of
      Default or any condition, event or act which with the giving of notice and/or the lapse of time and/or
      fulfillment of any other conditions and/or the making of any determination would constitute an Event
      of Default has happened and none of them shall be responsible or liable to Bondholders or any other
      person for not doing so.

9.14 For purposes of this Condition 9, “Principal Subsidiary” means any Subsidiary of the Issuer:

      (i)    whose total revenue (consolidated in the case of a Subsidiary which itself has Subsidiaries) as
             shown by its latest audited income statement is at least 5 percent of the consolidated total
             revenue as shown by the latest published audited income statement of the Issuer and its
             consolidated Subsidiaries; or

      (ii)   whose net profits (consolidated in the case of a Subsidiary which itself has Subsidiaries) as
             shown by its latest audited income statement is at least 5 percent of the consolidated gross profit
             as shown by the latest published audited consolidated income statement of the Issuer and its
             consolidated Subsidiaries, including for the avoidance of doubt, the Issuer and its consolidated
             Subsidiaries’ share of profits of Subsidiaries not consolidated and of jointly controlled entities
             and after adjustments for minority interests; or

      (iii) whose total assets (consolidated in the case of a Subsidiary which itself has Subsidiaries) as
            shown by its latest audited balance sheet are at least 5 percent of the consolidated net assets of
            the Issuer and its Subsidiaries as shown by the latest published audited consolidated balance
            sheet of the Issuer and its Subsidiaries, including the investment of the Issuer and its
            consolidated Subsidiaries in each Subsidiary whose accounts are not consolidated with the
            consolidated audited accounts of the Issuer and of associated companies and after adjustment for
            minority interests;


                                                      144
      (iv) to which is transferred the whole or substantially the whole of the assets of a Subsidiary which
           immediately prior to such transfer was a Principal Subsidiary, whereupon the Principal
           Subsidiary which so transfers its assets shall forthwith upon such transfer cease to be a Principal
           Subsidiary and the Subsidiary to which the assets are so transferred shall immediately become
           a Principal Subsidiary, provided that on or after the date on which the first published audited
           accounts (consolidated, if appropriate) of the Issuer prepared as of a date later than such transfer
           are issued, whether or not such transferor Subsidiary or transferee Subsidiary would continue to
           be a Principal Subsidiary shall be determined on the basis of such accounts by virtue of the
           provisions of (i), (ii) or (iii) above;

           provided that, in relation to paragraphs (i), (ii) and (iii) above of this definition:

           (a)   in the case of a corporation or other business entity becoming a Subsidiary after the end
                 of the financial period to which the latest consolidated audited accounts of the Issuer
                 relate, the reference to the then latest consolidated audited accounts of the Issuer and its
                 Subsidiaries for the purposes of the calculation above shall, until consolidated audited
                 accounts of the Issuer for the financial period in which the relevant corporation or other
                 business entity becomes a Subsidiary are published, be deemed to be a reference to the then
                 latest consolidated audited accounts of the Issuer and its Subsidiaries adjusted to
                 consolidate the latest audited accounts (consolidated in the case of a Subsidiary which
                 itself has Subsidiaries) of such Subsidiary in such accounts;

           (b)   if at any relevant time in relation to the Issuer or any Subsidiary which itself has
                 Subsidiaries, no consolidated accounts are prepared and audited, total revenue, gross profit
                 or net assets of the Issuer and/or any such Subsidiary shall be determined on the basis of
                 pro forma consolidated accounts prepared for this purpose by or on behalf of the Issuer;

           (c)   if at any relevant time in relation to any Subsidiary, no accounts are audited, its net assets
                 (consolidated, if appropriate) shall be determined on the basis of pro forma accounts
                 (consolidated, if appropriate) of the relevant Subsidiary prepared for this purpose by or on
                 behalf of the Issuer; and

           (d)   if the accounts of any Subsidiary (not being a Subsidiary referred to in proviso (i) above)
                 are not consolidated with those of the Issuer, then the determination of whether or not such
                 Subsidiary is a Principal Subsidiary shall be based on a pro forma consolidation of its
                 accounts (consolidated, if appropriate) with the consolidated accounts (determined on the
                 basis of the foregoing) of the Issuer;

                 A certificate signed by an Authorised Signatory of the Issuer stating that, in their opinion,
                 a Subsidiary is or is not, or was or was not, a Principal Subsidiary shall, in the absence of
                 manifest error, be conclusive and binding on all parties.

10.   Prescription

      Claims in respect of amounts due in respect of the Bonds will become prescribed unless made within
      10 years (in the case of principal) and five years (in the case of default interest, if any) from the
      Relevant Date in respect thereof.




                                                     145
11.   Meetings of Bondholders, Modification and Waiver

11.1 Meetings

      The Trust Deed contains provisions for convening meetings of Bondholders to consider any matter
      affecting their interests, including the sanctioning by Extraordinary Resolution of a modification of
      the Bonds or the provisions of the Trust Deed. Such a meeting may be convened by the Issuer or the
      Trustee and shall be convened by the Trustee if requested in writing to do so by Bondholders holding
      not less than 10 per cent. in principal amount of the Bonds for the time being outstanding and if it is
      indemnified and/or secured and/or pre-funded to its satisfaction against all costs and expenses. The
      quorum at any such meeting for passing an Extraordinary Resolution will be two or more persons
      holding or representing over 50 per cent. in principal amount of the Bonds for the time being
      outstanding or, at any adjournment of such meeting, two or more persons being or representing
      Bondholders whatever the principal amount of the Bonds so held or represented unless the business
      of such meeting includes consideration of proposals, inter alia, (i) to modify the due date for any
      payment in respect of the Bonds, (ii) to reduce or cancel the amount of principal or Equivalent Amount
      in respect of the Bonds, (iii) to change the currency of payment of the Bonds, or (iv) to modify or
      cancel the Conversion Rights or the put options specified in Condition 7 or (v) to modify the
      provisions concerning the quorum required at any meeting of the Bondholders or the majority required
      to pass an Extraordinary Resolution, in which case the necessary quorum for passing an Extraordinary
      Resolution will be two or more persons holding or representing not less than 75 per cent., or at any
      adjourned such meeting not less than 25 per cent., in principal amount of the Bonds for the time being
      outstanding. An Extraordinary Resolution passed at any meeting of Bondholders will be binding on
      all Bondholders, whether or not they are present at the meeting. The Trust Deed provides that a written
      resolution signed by or on behalf of the holders of not less than 90 per cent. of the aggregate principal
      amount of Bonds outstanding shall be as valid and effective as a duly passed Extraordinary
      Resolution.

11.2 Modification and Waiver

      The Trustee may (but shall not be obliged to) agree, without the consent of the Bondholders, to (i) any
      modification (except as mentioned in Condition 11.1 above and the Trust Deed) to, or the waiver or
      authorisation of any breach or proposed breach of, the Bonds, the Agency Agreement or the Trust
      Deed which is not, in the opinion of the Trustee, materially prejudicial to the interests of the
      Bondholders or (ii) any modification to the Bonds, the Agency Agreement or the Trust Deed which,
      in the Trustee’s opinion, is of a formal, minor or technical nature or to correct a manifest error or to
      comply with mandatory provisions of law. Any such modification, waiver or authorisation will be
      binding on the Bondholders and, unless the Trustee agrees otherwise, any such modification, waiver
      or authorisation will be notified by the Issuer to the Bondholders as soon as practicable thereafter.

11.3 Interests of Bondholders

      In connection with the exercise of its functions, rights, powers and discretions (including but not
      limited to those in relation to any proposed modification, authorisation or, waiver) the Trustee shall
      have regard to the interests of the Bondholders as a class and shall not have regard to the consequences
      of such exercise for individual Bondholders and the Trustee shall not be entitled to require on behalf
      of any Bondholder, nor shall any Bondholder be entitled to claim, from the Issuer or the Trustee any
      indemnification or payment in respect of any tax consequences of any such exercise upon individual
      Bondholders except to the extent provided for in Condition 8 and/or any undertakings given in
      addition thereto or in substitution therefor pursuant to the Trust Deed.




                                                     146
12.   Replacement of Certificates

      If any Certificate is mutilated, defaced, destroyed, stolen or lost, it may be replaced at the specified
      office of the Registrar or any Transfer Agent, subject to all applicable laws and stock exchange
      requirements, upon payment by the claimant of such costs as may be incurred in connection therewith
      and on such terms as to evidence and such indemnity and/or security as the Issuer and/or such Agent
      may require. Mutilated or defaced Certificates must be surrendered before replacements will be
      issued.

13.   Enforcement

      At any time when the Bonds become due and payable, the Trustee may, at its discretion and without
      further notice, take such steps and/or actions and/or institute such proceedings against the Issuer as
      it may think fit to enforce the terms of the Trust Deed and the Bonds, but it need not take any such
      steps and/or actions and/or institute any such proceedings unless (i) it shall have been so directed by
      an Extraordinary Resolution or shall have been so requested in writing by the holders of not less than
      25 per cent. in principal amount of the Bonds then outstanding and (ii) it shall have been indemnified
      and/or secured and/or pre-funded to its satisfaction. No Bondholder may proceed directly against the
      Issuer unless the Trustee, having become bound so to proceed, fails to do so within a reasonable period
      and such failure is continuing.

14.   Indemnification of the Trustee

      The Trust Deed contains provisions for the indemnification of the Trustee and for its relief from
      responsibility including without limitation from taking proceedings to enforce payment unless
      indemnified and/or secured and/or prefunded of its satisfaction. The Trustee is entitled to enter into
      business transactions with the Issuer and any entity related (directly or indirectly) to the Issuer without
      accounting for any profit.

      The Trustee may rely without liability to Bondholders on any report, confirmation or certificate from
      or any advice or opinion of any legal counsel, accountants, financial advisers, financial institution or
      any other expert, whether or not obtained by or addressed to it and whether their liability in relation
      thereto is limited (by its terms or by any engagement letter relating thereto entered into by the Trustee
      or any other person or in any other manner) by reference to a monetary cap, methodology or otherwise.
      The Trustee may accept and shall be entitled to rely on any such report, confirmation, certificate,
      advice or opinion, in which case such report, confirmation, certificate, advice or opinion shall be
      binding on the Issuer and the Bondholders.

      Whenever the Trustee is required or entitled by the terms of the Trust Deed or these Conditions to
      exercise any discretion or power, take any action, make any decision or give any direction, the Trustee
      is entitled, prior to exercising any such discretion or power, taking any such action, making any such
      decision or giving any such direction, to seek directions from the Bondholders by way of
      Extraordinary Resolution, and the Trustee shall not be responsible for any loss or liability incurred by
      the Issuer, the Bondholders or any other person as a result of any delay in it exercising such discretion
      or power, taking such action, making such decision or giving such direction as a result of seeking such
      direction from the Bondholders or in the event that no direction is given to the Trustee by the
      Bondholders.




                                                      147
      None of the Trustee or any of the Agents shall be responsible for the performance by the Issuer and
      any other person appointed by the Issuer in relation to the Bonds of the duties and obligations on their
      part expressed in respect of the same and, unless it has written notice from the Issuer to the contrary,
      the Trustee and each Agent shall assume that the same are being duly performed. None of the Trustee
      or any Agent shall be liable to any Bondholder or any other person for any action taken by the Trustee
      or such Agent in accordance with the instructions of the Bondholders. The Trustee shall be entitled
      to rely on any direction, request or resolution of Bondholders given by holders of the requisite
      principal amount of Bonds outstanding or passed at a meeting of Bondholders convened and held in
      accordance with the Trust Deed. Neither the Trustee nor any of the Agents shall be under any
      obligation to ascertain whether any Event of Default or Potential Event of Default has occurred or
      monitor compliance by the Issuer with the provisions of the Trust Deed, the Agency Agreement or
      these Conditions.

      Each Bondholder shall be solely responsible for making and continuing to make its own independent
      appraisal and investigation into the financial condition, creditworthiness, condition, affairs, status and
      nature of the Issuer and its Subsidiaries, and the Trustee shall not at any time have any responsibility
      for the same and each Bondholder shall not rely on the Trustee in respect thereof.

15.   Further Issues

      The Issuer may from time to time, without the consent of the Bondholders, create and issue further
      bonds having the same terms and conditions as the Bonds in all respects (or in all respects except for
      the issue date and the timing for complying with the requirements set out in these Conditions in
      relation to the NDRC Post-issue Filing and the Foreign Debt Registration) and so that such further
      issue shall be consolidated and form a single series with the Bonds. Such further bonds shall be
      constituted by a deed supplemental to the Trust Deed.

16.   Notices

      All notices to Bondholders shall be validly given if mailed to them at their respective addresses in the
      register of Bondholders maintained by the Registrar or published in a leading newspaper having
      general circulation in Asia (which is expected to be the Asian Wall Street Journal) and, so long as the
      Bonds are listed on the Hong Kong Stock Exchange and the rules of that stock exchange so require,
      published in a leading newspaper having general circulation in Hong Kong (which is expected to be
      the South China Morning Post). Any such notice shall be deemed to have been given on the later of
      the date of such publication and the seventh day after being so mailed, as the case may be. A copy
      of all such notices to Bondholders (or a Bondholder) or the Trustee pursuant to these Conditions shall
      be given simultaneously to the Calculation Agent.

      As long as the Bonds are represented by the Global Certificate and the Global Certificate is held on
      behalf of Euroclear or Clearstream or an alternative clearing system, notices to Bondholders may be
      given by delivery of the relevant notice to Euroclear or Clearstream or the alternative clearing system,
      for communication by it to entitled accountholders in substitution for notification as required by the
      Conditions and such delivery shall be deemed to be valid for all purposes of these Conditions.

17.   Contracts (Rights of Third Parties) Act 1999

      No person shall have any right to enforce any term or condition of the Bonds under the Contracts
      (Rights of Third Parties) Act 1999 but this is without prejudice to the rights of Bondholders as
      contemplated in Condition 13.




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18.   Governing Law and Jurisdiction

18.1 Governing Law

      The Bonds, the Trust Deed and the Agency Agreement and any non-contractual obligations arising out
      of or in connection with them are governed by, and shall be construed in accordance with, English law.

18.2 Jurisdiction

      The courts of Hong Kong are to have exclusive jurisdiction to settle any disputes which may arise out
      of or in connection with the Bonds and accordingly any legal action or proceedings arising out of or
      in connection with the Bonds and/or the Trust Deed (“Proceedings”) may be brought in such courts.
      Pursuant to the Trust Deed, the Issuer has irrevocably submitted to the jurisdiction of such courts.

18.3 Waiver of Immunity

      The Issuer has waived any right to claim sovereign or other immunity from jurisdiction or execution
      and any similar defense, and has irrevocably consented to the giving of any relief or the issue of any
      process, including, without limitation, the making, enforcement or execution against any property
      whatsoever (irrespective of its use or intended use) of any order or judgment made or given in
      connection with any Proceedings.




                                                    149
SUMMARY OF PROVISIONS RELATING TO THE BONDS IN GLOBAL FORM

Each Global Certificate contains provisions which apply to the respective Series of the Bonds in respect of
which such Global Certificate is issued, some of which modify the effect of the Conditions of the Bonds
of the relevant Series set out in this Offering Circular. Terms defined in the Conditions have the same
meaning in the paragraphs below. The following is a summary of those provisions:

PAYMENT

So long as the Bonds are represented by the Global Certificate and such Global Certificate is held on behalf
of a clearing system, the Issuer promises to pay the amount payable upon redemption under the Conditions
in respect of the Bonds and to pay interest in respect of the Bonds from the Issue Date in arrear at the rates,
on the dates for payment, and in accordance with the method of calculation provided for in the Terms and
Conditions, save that the calculation is made in respect of the total aggregate amount of the Bonds
represented by the Global Certificate together with such other sums and additional amounts (if any) as may
be payable under the Conditions.

Each payment will be made to the person shown as the holder in the Register at the close of business of
the relevant clearing system on the Clearing System Business Day before the due date for such payments,
where “Clearing System Business Day” means a weekday (Monday to Friday, inclusive) except December
25 and January 1.

EXCHANGE OF BONDS REPRESENTED BY GLOBAL CERTIFICATES

Owners of interests in the Bonds in respect of which the Global Certificate is issued will be entitled to have
title to the Bonds registered in their names and to receive individual definitive Certificates if either
Euroclear or Clearstream or any other clearing system as shall have been selected by the Issuer and
approved in writing by the Trustee, the Principal Agent and the Registrar through which the Bonds are held
(the “Alternative Clearing System”) is closed for business for a continuous period of 14 days (other than
by reason of holidays, statutory or otherwise) or announces an intention permanently to cease business or
does in fact do so. In such circumstances, the Issuer will at its own expense cause sufficient individual
definitive Certificates to be executed and delivered to the Registrar for completion, authentication and
despatch to the relevant holders of the Bonds. A person with an interest in the Bonds in respect of which
the Global Certificate is issued must provide the Registrar not less than 30 days’ notice at its specified office
of such holder’s intention to effect such exchange and a written order containing instructions and such other
information as the Issuer and the Registrar may require to complete, execute and deliver such individual
definitive Certificates.

NOTICES

So long as the Bonds are represented by the Global Certificate and the Global Certificate is held on behalf
of Euroclear or Clearstream or any Alternative Clearing System, notices to Bondholders may be given by
delivery of the relevant notice to Euroclear or Clearstream or the Alternative Clearing System, for
communication by it to accountholders entitled to an interest in the Bonds in substitution for notification
as required by the Conditions.

MEETINGS

For the purposes of any meeting of Bondholders, the registered holder of the Bonds represented by the
Global Certificate will be treated as being two persons for the purposes of any quorum requirements of a
meeting of Bondholders and as being entitled to one vote in respect of each US$200,000 in principal amount
of the Series 1 Bonds or RMB2,000,000 in principal amount of the Series 2 Bonds for which the Global
Certificate is issued.


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REDEMPTION AT THE OPTION OF THE BONDHOLDERS

The Bondholder’s redemption options in Condition 7.4 (Redemption at the Option of the Bondholders) and
Condition 7.5 (Redemption for Relevant Events) of the Conditions may be exercised by the holder of the
Global Certificate giving notice to the Paying Agent of the principal amount of Bonds in respect of which
the option is exercised within the time limits specified in the Conditions.

REDEMPTION AT THE OPTION OF THE ISSUER

The options of the Issuer provided for in Condition 7.2 (Redemption at the Option of the Issuer) and
Condition 7.3 (Redemption for Taxation Reasons) of the Conditions shall be exercised by the Issuer giving
notice to the Bondholders within the time limits set out in and containing the information required by the
relevant Condition.

BONDHOLDER’S TAX OPTION

The option of Bondholders not to have the Bonds redeemed as provided in Condition 7.3 (Redemption for
Taxation Reasons) of the Conditions shall be exercised by the presentation to any Paying Agent of a duly
completed Bondholder’s election notice within the time limits set out in and containing the information
required by Condition 7.3 (Redemption for Taxation Reasons).

TRANSFERS

Transfers of beneficial interests in the Bonds represented by the Global Certificate will be effected through
the records of Euroclear and Clearstream (or any Alternative Clearing System) and their respective
participants in accordance with the rules and procedures of Euroclear and Clearstream (or such Alternative
Clearing System) and their respective direct and indirect participants.

CANCELLATION

Cancellation of any Bond by the Issuer following its redemption, conversion or purchase by the Issuer and
its Subsidiaries will be effected by a reduction in the principal amount of the Bonds in the register of
Bondholders and the Global Certificate.

CONVERSION

Subject to the requirements of Euroclear and Clearstream (or any Alternative Clearing System), the
Conversion Rights attaching to the Bonds in respect of which the Global Certificate is issued may be
exercised by the presentation to or to the order of the Principal Agent of one or more Conversion Notices
duly completed by or on behalf of a holder of a book-entry interest in such Bonds. Deposit of the Global
Certificate with the Principal Agent together with the relevant Conversion Notice(s) shall not be required.
The exercise of the Conversion Right shall be notified by the Principal Agent to the Registrar and the holder
of the Global Certificate.

TRUSTEE’S POWERS

In considering the interests of Bondholders while the Global Certificate is registered in the name of a
nominee for a clearing system, the Trustee may, to the extent it considers it appropriate to do so in the
circumstances, but without being obliged to do so, (a) have regard to any information as may have been
made available to it by or on behalf of the relevant clearing system or its operator as to the identity of its
accountholders (either individually or by way of category) with entitlements in respect of the Bonds and
(b) consider such interests on the basis that such accountholders were the holders of the Bonds in respect
of which the Global Certificate is issued.


                                                     151
                                       USE OF PROCEEDS

The net proceeds from this offering, after the deduction of fees, commissions and expenses payable in
connection with this offering, will be approximately US$587.5 million. The Issuer intends to use the
proceeds for, among others, (i) expanding capacities and capabilities of our pharmaceutical process
development and manufacturing facilities (i.e., CMC services) for small molecule drugs; (ii) expanding our
R&D and manufacturing service platform for biologics; (iii) expanding capabilities of our laboratory
services; (iv) expanding capacities and capabilities of our laboratory and manufacturing facilities in the UK
and (v) working capital and general corporate purposes.




                                                    152
                                     CAPITALIZATION AND INDEBTEDNESS

The following table sets forth the Company’s audited consolidated capitalization as at December 31, 2020
and as adjusted to give effect to the issue of the Bonds before deduction of any fees, commissions and
expenses. The table should be read in conjunction with the financial statements and the accompanying notes
included in this Offering Circular.

                                                                                                As at December 31, 2020
                                                                                     Actual                              As adjusted
                                                                         (RMB in               (US$ in            (RMB in         (US$ in
                                                                         millions)            millions)(1)        millions)      millions)(1)
Indebtedness:
current portion
Interest-bearing bank and other borrowings ..                                   386                      60              386                60
non-current portion
Interest-bearing bank and other borrowings ..                                   395                      62              395                62
                           (2)
Bonds to be issued               .....................................               –                      –        3,834              600
Total indebtedness .......................................                      781                    122             4,615              722
Equity
Share capital .................................................                  794                  124                794             124
Treasury shares .............................................                    (45)                  (7)               (45)             (7)
Reserves ........................................................              8,121                1,271              8,121           1,271
Non-controlling interests ...............................                         64                   10                 64              10
Total shareholders’ equity...........................                         8,934                1,398              8,934           1,398
                           (3)
Total capitalization              ....................................         9,715                1,520            13,549            2,120


(1)    Translation of currency amounts between Renminbi and US$ have been made at the rate of RMB6.3895 to US$1.00, as reported
       by the Hong Kong Treasury Markets Association and appearing on the Bloomberg page “TMA” USD/CNH spot benchmark on
       June 8, 2021.

(2)    In accordance with International Accounting Standard 32 “Financial Instruments: Disclosure and Presentation”, a convertible
       bond should be separated into an equity and a liability component. For illustrative purposes only, the aggregate principal amount
       of the Bonds to be issued has been presented as a liability in the above table.

(3)    Total capitalization represents the sum of the total indebtedness and total shareholders’ equity.


The Company has incurred and will continue to incur additional indebtedness since December 31, 2020
during its ordinary course of business. Except as disclosed above and in this Offering Circular, there have
been no material changes in the Company’s total capitalization since December 31, 2020.




                                                                         153
                                DESCRIPTION OF THE GROUP

Overview

Pharmaron is a leading fully-integrated pharmaceutical R&D service platform with global operations to
accelerate drug innovation for our customers. The Company is one of the top three drug discovery service
providers globally in terms of total revenue in 2020, according to Frost & Sullivan. The Company has
established our leadership in drug discovery, pre-clinical and early clinical-stage development, while it has
also been expanding its capabilities downstream to late clinical-stage development and commercial
manufacturing. In expanding along the pharmaceutical R&D process, the Company has established
expertise in all major R&D functions to deliver key milestones in each R&D stage, thereby enabling its
customers to conduct their R&D programs in an accelerated manner.

As a leading drug discovery pharmaceutical R&D service provider, the Company accumulated profound
scientific insights on molecules and built customers’ trust since early stage of their innovative drug research
and development. As such, when its customers further develop their R&D programs to the preclinical and
clinical development stages, the Company is in the unique position to become their partner of choice in their
subsequent R&D programs. In order to meet the customers’ needs for R&D services, the Company naturally
expanded its service offerings into clinical development and CMC (small molecule CDMO) services and
became a fully integrated service provider. In 2019 and 2020, the Company further expanded its service
offerings into biologics services and strengthened our technology platforms through strategic acquisitions
in the U.S. and the U.K. the Company’s integrated solutions and profound understanding of customers’
needs further enable it to provide customized pharmaceutical R&D services beyond service and geographic
boundaries.

The Company operates globally through its 16 laboratories, clinical and manufacturing facilities in China,
the U.S. and the U.K., of which eight operating facilities are located overseas. The Company’s profound
experience in global pharmaceutical R&D, together with its global operations and world-class technical
capabilities, allows it to offer its customers a unique proposition that combines the Company’s technical
expertise in different geographic location and efficient services with seamless integration. In addition, the
Company’s experience to conduct regulatory filings in various jurisdictions and its total solution approach
enable its customers to file investigational new drug (IND) applications for their drug candidates in China,
the U.S. or Europe in parallel and better support them when they enter into the overseas markets, which
provides greater flexibility and efficiency in their business development strategies. In 2020, the Company
submitted 58 IND applications for its pharmaceutical and biotech customers in China, among which 46 were
IND applications targeting multiple jurisdictions (include China, the U.S. and EU), which demonstrated the
advantage of and strong demand for its total solution approach.

The Company has a large, diverse and loyal customer base. As of December 31, 2020, it had an aggregate
of over 1,500 customers, which included all of the top 20 global pharmaceutical companies that contributed
to 23.7% of its revenue in 2020, and many reputable biotech companies. The Company is also a partner of
choice of fast-growing start-ups and virtual biotech companies. Its loyal and growing customer base allows
it to expand to new services along the drug discovery and development processes, as its existing customers’
projects progress further. In addition, the comprehensive service offerings of the Company enable it to
cross-sell services of different scientific functions to meet the customers’ evolving needs. For example, over
80% of the revenue from its biologics services in 2020 was generated from its existing customers who used
the Company’s laboratory services for small molecule drugs, and nearly 80% of the revenue from the
Company’s CMC (small molecule CDMO) services in 2020 was generated from existing customers using
its laboratory services. The strong execution capabilities of the Company and quality customer services are
widely recognized by our customers, which increases its customer stickiness and enables it to develop long
term cooperation/partner relationship with them.




                                                      154
The Company is devoted to providing customers with world-class pharmaceutical R&D services. Since
inception, the Company has put great emphasis on technology and innovation to fuel the constant growth
of its business and satisfy the evolving R&D needs of its customers. It develops new technologies through
multiple measures such as internal research and development, collaboration with academic and professional
institutions, customer collaboration and acquisitions. In recent years, the Company has been strategically
developing new technologies and capabilities in chemistry and bioscience areas, and committed to further
strengthening of the integrated services platform.

Led by Dr. LOU, the chairman and chief executive officer of the Company, the highly skilled and
experienced management team with diverse expertise and extensive knowledge has significantly
contributed to the growth of the Company’s institutional knowledge base. In addition, their international
background, together with their deep understanding of the China market and the open and embracing
corporate culture of the Group, provide it with global expansion capabilities. In addition, the management
team of the Company has established a highly experienced talent pool with strong execution capabilities.
As of December 31, 2020, it had over 9,800 scientists and research technicians in China, the U.K. and the
U.S. The Company is committed to its corporate philosophy of “Employee First and Customer Centric”
which puts strong emphasis on employee training and improves all mechanisms so as to integrate their
career development into the Company’s overall development strategy. In order to develop and train its
talents, the Company provides continuous training programs to its employees through “Pharmaron
College,” visiting scholar programs and various symposiums, forums and lectureship. Through these
initiatives, its team members can acquire updates on the most advanced technology and techniques, thereby
supporting the Company’s continued and sustainable expansion with a cohesive, vibrant and stable
mid-level management team.

The Company experienced significant growth during the three years ended December 31, 2020. Its revenue
increased significantly from RMB2,908.1 million in 2018 to RMB3,757.2 million in 2019 and further to
RMB5,133.6 million in 2020, representing a CAGR of 32.9%. Its net profit increased significantly from
RMB335.8 million in 2018 to RMB530.7 million in 2019 and further to RMB1,147.0 million in 2020,
representing a CAGR of 84.8%.

The following table sets forth the breakdown of the Group’s revenue by segment for the periods indicated:

                                                                                                For the year ended December 31,
                                                                                         2020                2019                 2018
                                                                                       RMB’000            RMB’000          RMB’000
Laboratory services ........................................................            3,262,714           2,379,509         1,895,755
CMC (small molecule CDMO) services .........................                            1,221,985             901,576           645,824
Clinical development service..........................................                    629,350             456,265           347,504
Others.............................................................................        19,548              19,810            19,040
Total ..............................................................................    5,133,597           3,757,160         2,908,123


Competitive Strengths

Leading fully-integrated pharmaceutical R&D services platform with strong capabilities and
comprehensive service offerings across the globe

The Company has a well-established pharmaceutical R&D services platform for the discovery stage of small
molecule innovative drugs, based on which the Company has expanded its expertise to various stages of
drug development and manufacturing. The Company is in a leading position in drug discovery, preclinical
and early clinical-stage research, and is committed to expanding its capabilities downstream to late
clinical-stage development and commercial manufacturing. In the process of expanding R&D services, the
Company has successfully evolved from a pure laboratory chemistry service provider to an end-to-end
pharmaceutical R&D services platform with operations in China, the U.S. and the U.K. The Company has
established comprehensive expertise in different R&D stages, so as to assist customers in accelerating their


                                                                            155
R&D programs and cater to a full spectrum of customers’ needs. The Company has established a good
reputation in the global pharmaceutical R&D service industry and a strong partnership with top
pharmaceutical and biotech companies. Through the comprehensive early-stage drug R&D services, we
have accumulated a profound understanding of the unique scientific challenges facing their new
pharmaceutical R&D projects, which better positions the Company to press ahead with such projects in the
late development stage. The Company’s profound industry knowledge, strong execution capability and
end-to-end solutions will shorten the drug discovery and development cycle and reduce the associated risks,
thereby creating value for customers. As a fully-integrated pharmaceutical R&D service provider, the
Company’s comprehensive pharmaceutical R&D services platform has the following three core
competences:

(1)   Comprehensive chemistry platform throughout the entire drug R&D and commercial stages

      As a fully-integrated service provider for the research, development and manufacturing of small
      molecule pharmaceutical products, the Company’s expertise and advantage in chemistry technology
      is crucial throughout the whole drug R&D process.

      With the comprehensive chemical technology platform covering compound design (including CADD),
      design and synthesis of a compound library, medicinal chemistry, synthetic chemistry, analytical
      chemistry, early process chemistry, and process chemistry and GMP API manufacturing, the Company
      can satisfy customers’ demand for pharmaceutical R&D and manufacturing in each stage of the
      pharmaceutical R&D process, including laboratory synthesis process at the drug discovery stage,
      small-scale process and GLP/GMP manufacturing at the preclinical drug development stage,
      mid-scale process and GMP manufacturing at the clinical stage as well as process development for
      GMP commercial manufacturing, which fully cater to the diversified needs of different types of
      customers. In addition to providing R&D services for the compound synthesis process, combined with
      its formulation development services, the Company is able to provide customers with fully-integrated
      pharmaceutical R&D and manufacturing solutions from initial compounds to finished dosages.

(2)   DMPK/ADME service platform throughout the entire drug R&D process

      The Company provides DMPK/ADME services covering the whole R&D process from drug discovery
      to development. The early DMPK/ADME studies are of great importance as they can provide a key
      basis for our customers to determine their late-stage drug development strategy. Radioisotopic
      analysis technology is critical as an important drug metabolism analysis technology during the clinical
      stage. Following the approval of the radioisotopic use license at the Company’s clinical center in the
      U.S. in early 2018, the Company is the only pharmaceutical R&D service provider that offers
      integrated pharmaceutical R&D solutions, which cover radioisotope compound synthesis and human
      ADME studies using regular isotope analysis technology or high-sensitivity AMS technology. In
      addition, with acquisition of Absorption Systems, the Company broadened its global service network
      and further strengthen its leading position in discovery and development DMPK platform.

(3)   Comprehensive integrated platform from drug discovery to proof-of-concept (POC)

      From inception, the Company has committed to the establishment of integrated services platform from
      drug discovery to proof of concept stage, which covers compound design, compound library synthesis,
      synthetic and medicinal chemistry, biology, DMPK, pharmacology, toxicology, drug safety
      assessment, radiolabelled chemistry and DMPK, clinical pharmacology, clinical bioanalysis, clinical
      data statistics, chemical process development and API manufacturing and formulation and drug
      product manufacturing. With this comprehensive integrated services platform, the Company has
      undertaken many integrated research projects, and achieved a considerable number of milestones. In
      addition, the Company can also provide a customized service package at a particular stage of drug
      R&D process, such as an integrated service package for IND enabling which includes preclinical
      safety assessment, early process development and manufacturing, pharmacology, DMPK and clinical
      proposal. With this comprehensive IND enabling solutions and the ability to support IND filing for
      different jurisdictions, it provides flexibility to the customers, accelerates their drug development
      process and reduces their overall R&D costs.


                                                    156
Global operations, profound experience in pharmaceutical R&D and state-of-the-art technologies to
provide customized solutions

The Company operates globally through our 16 laboratories, clinical and manufacturing facilities in China,
the U.S. and the U.K., of which 8 operating facilities from overseas. The Company’s profound experience
in global pharmaceutical R&D, together with its global operations and world-class technical capabilities,
allow us to offer our customers a unique proposition that combines our technical expertise in different
geographic location and efficient services with seamless integration. The Company has a proven track
record of offering customized solutions to customers to address their specific needs by integrating the
expertise from our global operations.

It is the Company’s core strategy for each international acquisition to effectively integrate with our global
services platform and brought in the world class talent and facilities into our integrated services platform
to further strengthen our overall services capabilities and increase the efficiency of our services. These
strategies complement each other to effectively improve the Company’s international operation capability
and bring high value-added services to customers. For example, our process chemistry and drug discovery
team in U.K. and China worked closely together to provide customized solutions with hybrid model which
continued to gain recognition from customers.

Through our global operation, the Company has established a services network and strategic presence in
global life science hubs which enhance the customer communication and understanding of customer needs.
Also, by carrying out our R&D services under different jurisdictions, it provides flexibility to customize our
services solutions that best suit our customers’ geographic and strategic needs. The clinical pharmacology
team in the U.S. has worked seamlessly with our Chinese team to help customers in China for the
preparation and filing of IND application and conducted the first-in-human (FIH) studies in the U.S. In
addition, the Company’s experience in regulatory filings in various jurisdictions and its service model of
providing customers with total solution enable our customers to file IND applications for their drug
candidates in China, the U.S., or EU in parallel, which makes the IND applications of our customers more
flexible and efficient.

Committed to utilizing innovative technologies to meet evolving R&D needs and increase efficiency

Since inception, the Company has put great emphasis on technology and innovation to fuel the constant
growth of the business and satisfy the evolving R&D needs. It develops new technologies through multiple
measures such as internal research and development, collaboration with academic and professional
institutions, customer collaboration and acquisitions. In recent years, the Company has been strategically
developing new technologies and capabilities in chemistry and bioscience areas, and committed to further
strengthening of the integrated services platform.

In the chemical synthesis and manufacturing technology area, we focus on the application of the high
throughput chemical reaction screening platform, flow chemical technology and biocatalysis technology.
Using infinitesimal reaction materials to attempt a reaction condition, the high throughput chemical reaction
screening platform can assess dozens or even hundreds of catalytic reaction conditions in a short time, to
assist in finding the best synthetic solutions. In 2020, it assisted the chemistry departments in resolving
nearly 2,000 challenging chemical reactions. The flow chemistry team completed more than 50 different
types of flow reaction projects with the largest scale up to 140kg. Furthermore, the Company established
a dedicated biocatalysis department in 2020, which had developed nearly 1,000 biocatalytic enzymes for a
wide range of organic synthesis reactions, including oxidation, reduction, transamination, esterification and
ester hydrolysis.

In the discovery and bioscience area, the Company had established DNA-encoded Library (DEL) screening
platform, chemopoteomics platform, in vivo imaging technology platform and 3D spheroid and organoid
screening platform. In 2020, the Company conducted hit screening campaigns using Pharmaron DEL
against the new biological target of interest and successfully identified several novel hit compound series
for the customers, which not only helped our customers to speed up their drug discovery programs, but also
laid concrete foundation for attracting more customers for our DEL services. The chemopoteomics platform


                                                     157
using activity and reactivity-based probes together with proteomics profiling allows quick identification of
interacting proteins and targets within the cells or tissues. The in vivo imaging technology platform can
provide valuable data to support drugability evaluation with respect to the efficacy and safety of potential
drugs. Our image technology platform can quantify potential drugs’ tissue distribution dynamically in
rodent tumor model using radioisotope labelled compounds. In addition, we had developed a simplified
method that could conduct isotopic tracing and assess the qualitative and quantitative distribution of
compounds in animal at different time points in a faster, more efficient and low-cost manner which can
further promotion the application of such technology in early drug discovery programs. Also, we are in the
process of building up 3D spheroids and organoid screening platform which are closer to the complex in
vivo conditions as compared to traditional 2D culture. Using 3D spheroids and organoids as in vitro assay
platform to investigate the potential efficacy and safety of drugs has more clinical significance.

Dedicated, stable and visionary management teams, experienced talent pools with progressive corporate
culture

The Company’s management team is led by Dr. LOU Boliang, our chairman and chief executive officer.
With over 30 years of experience in the pharmaceutical industry, he is highly respected in the industry for
his excellent leadership that contributes to the Company’s rapid development. The Company’s senior
management team has been with us for more than 10 years. The Company has nearly 100 senior scientific
and technical leaders, 3 of whom were named as National Talents and 15 named as Beijing Talents.
Members of our highly skilled, experienced and international management team possess diverse expertise
and extensive knowledge, and have significantly contributed to the growth of the Company’s institutional
knowledge base. The Company focuses on its home-grown scientific team consisting of selected, young and
promising scientists, which enables us to form a cohesive and vibrant mid-level management team
composed of nearly 2,000 technical managers and high-caliber scientific research talents across all
scientific disciplines of the Company. In addition, the Company’s visionary management team has
established a highly experienced and skilled talent pool with strong execution efficiency. As of December
31, 2020, the Company had over 9,800 R&D, production technology and clinical services staff in China,
the U.K. and the U.S.. The highly professional technical team ensures the Company’s continuous provision
of high-quality R&D services for customers. The open platform for talent development ensures that the
Company will continuously attract talents from around the globe.

The Company is committed to its corporate philosophy of “Employee First and Customer Centric” which
puts strong emphasis on employee training and improves all mechanisms so as to integrate their career
development into the Company’s overall development strategy. In order to develop and train our talents, the
Company provides training to our employees through our in-house training system including the
“Pharmaron College”, visiting scholar programs at renowned laboratories and institutions and holds various
seminars, forums and academic symposiums regularly, through which our team members acquire updates
on the most advanced technology and techniques of the industry. In addition, the Company has developed
training programs with the world renowned universities and research institutes for high-caliber scientific
research talent. The above measures have greatly improved the scientific research capabilities and cohesion
of the Company and its employees. Furthermore, we respect and value every single customer so as to ensure
R&D quality by tackling each technical challenges and complete every single tasks with integrity and
scientific rigor.

Our dedicated, stable and visionary management team, experienced talent pool and outstanding corporate
culture lay a solid foundation for the Company’s long-term success.

Reputable, loyal and expanding customer base that contributes to our sustainable growth and business
collaboration

The Company has a large, diverse and loyal customer base consisting of more than 1,500 customers,
including the global top 20 pharmaceutical companies and numerous reputable biotech companies. In 2020,
the Company introduced 721 new customers, with over 90% of revenue contributed by the Company’s large,
diverse and loyal repeat customers The Company’s fully-integrated solution and deep understanding of
customers’ needs allow it to provide customized pharmaceutical R&D services for customers according to
their needs. With further progress made in the existing customers’ projects, the loyal and growing customer
base will enable us to develop new services in drug development and at the early clinical stage.


                                                    158
The Company benefits from its strategic partnership with specific customers. Through know-how sharing
and training provided during our deep collaboration with these customers, the Company is able to further
improve technical capabilities and enhance service excellence, thereby creating a virtuous cycle. With our
strong technical expertise, advanced technological infrastructure, profound industry knowledge, strong
execution capability and quality customer services, the Company is able to become our customers’ strategic
partner and help them form their drug development or R&D outsourcing strategies, which in turn reinforces
our close relationships with such customers. In addition to our strong scientific capabilities, the Company
puts emphasis on areas like environmental protection, health, safety and intellectual property protection.
The Company takes such measures as establishing the intellectual property protection system and building
the information system to ensure that our customers’ intellectual properties are well protected, and is widely
recognized and trusted by customers in this respect. The Company’s high-quality services enable us to
accumulate a good reputation among our existing customers, and to further expand our customer base by
acquiring new customers through word-of-mouth referrals.

Insight into industry trends and well positioned to capture growth opportunities arising from industry
evolution

The Company, with profound industry accumulation, large customer base and close partnership, keeps
abreast of the global pharmaceutical R&D trends. It’s strong awareness and understanding of evolving R&D
needs allow the Company to be adaptive and expand into new emerging fields and implement innovative
technology to better serve our customers.

It is a trend for pharmaceutical R&D companies to enter into deeper collaborations with their
pharmaceutical R&D service providers that provide end-to-end services with good track records to achieve
higher R&D efficiency. In addition, the number of biotech start-ups and their R&D investments increase
rapidly. Out of consideration of costs and time efficiency, these biotech start-ups more extensively use the
fully-integrated R&D services platform to support their pharmaceutical R&D programs. Through long-term
collaboration with customers, the Company will contribute to transforming the drug R&D industry in a
more efficient way and continuously benefit from the growing demand for pharmaceutical R&D services.

Along with the trend of the Chinese pharmaceutical industry shifting from generic drugs to innovative drugs
and the rapidly increasing number of biotech start-ups in China, making it the fastest-growing
pharmaceutical R&D services market across the world. The Company is well-positioned to capitalize on the
strong growth drivers in China’s pharmaceutical R&D industry and further strengthen its leadership in such
a market.

Growth Strategies

The Group aims to solidify its leading position as a global fully-integrated pharmaceutical R&D service
platform. In order to achieve this goal, The Group has been executing and will continue to execute the
following key strategies:

Continue to maintain our leading position in pharmaceutical R&D services of small molecule innovative
drugs and further enhance our technologies and expand our global footprint

Advanced technologies are crucial for the Company to maintain its leading position in the small molecule
area. The Company will continuously invest in the latest small molecule technology to expand its services
offerings. In addition, with the increasing demand from pharmaceutical community for integrated
pharmaceutical R&D services solutions, the Company will continue to strengthen its end-to-end services
platform to further improve its market competitiveness.

In addition, the Company will further enhance its ability to bring in world-class talent and state-of-the-art
technologies to its integrated services platform through global footprint expansion. This will further
enhance its ability in providing customized solutions to customers by integrating the expertise and presence
from its global operations.


                                                     159
Accelerate the buildup of biologics and CGT services platform

While the Company maintains its leading position in pharmaceutical R&D services of small molecule
innovative drugs, it plans to accelerate the build-up of its biologics and cell and gene therapy (CGT)
services platform. The Company will continue to develop the biologics services capabilities by expanding
its team and introduce more professional talent, accelerate the construction of biologics manufacturing
capabilities and capacities in China, and establish a quality system that meet the highest international
standard.

In addition, leveraging on the CGT product evaluation expertise and CDMO capabilities the Company
acquired through the recent acquisitions of Absorption System and Allergan Biologics Limited, the
Company believes it is well positioned to establish a global CGT service platform which provide
unparalleled value proposition to its partners in this rapidly growing field of innovative therapies.

Deepen collaborations with existing customers and broaden customer base

As a leader in the global pharmaceutical R&D service industry, the Company has provided high-quality
services to over 1,500 biotech and pharmaceutical customers worldwide. As the Company continue to
expand its capabilities downstream to late clinical-stage development and commercial manufacturing, it
plans to leverage its loyal customer base and further deepen its business collaborations with existing
customers to cross-sell its diverse and comprehensive service offerings to them and further increase its
market penetration. In addition, the Company also plans to leverage its dedicated business development
team and deep industry knowledge to further expand its customer base, in particular among the fast-growing
start-up and virtual biotech companies. The Company believes the breadth and depth of its integrated and
customized solutions and quality services, combined with its reputation accumulated from existing
customer relationships, position the Company well to capture an increasing share of its customers’ R&D
spending as their business grow. The increasing capacity and further enhanced capabilities in CMC and
small molecule CDMO services will also provide the Company with greater growth potential, in particular
in the China market.

In the overseas market, the Company will continue to maintain its solid relationships with its existing
customer base, deeply analyze and explore customer needs, expand its service offerings, and introduce new
customers with the help of its reputation and brand influence. In the domestic market, the Company will
pay more attention in cultivating the domestic market and adopt a specific market strategy to address the
domestic needs to improve its competitiveness in the domestic market. With the increase of the Company’s
late stage CMC (small molecule CDMO) service capacity, it is seeking further expansion in the domestic
market.

Continue to enlarge our talent pool and enhance our operation efficiency to support long-term and
sustainable growth

The Company believes its scientists and research technicians are crucial to its ability to provide high quality
services to the customers and it will continue to uphold its corporate philosophy of “Employee First and
Customer Centric”. To maintain the high service quality and industry leading expertise, and to continuously
meet its customers’ evolving demands, the Company will continue to recruit, train, promote and retain the
most talented individuals in its industry. In addition, it will continue to nurture future scientific and
management talents within the Company through the Pharmaron College and other training programs and
initiatives. Furthermore, the Company has adopted various measures to attract and retain promising talents
in its industry. With its recruiting efforts, global footprint, fully-integrated platform and competitive
compensation package including share-based incentives, the Company believes it will effectively secure its
demand for the talents and serve its customers beyond boundaries.

To enhance its management efficiency and achieve a sustainable growth, the Company will further integrate
its global resources and improve the execution efficiency of its management team to better support its global
expansion strategy.


                                                     160
      Group Structure

      The following chart summarizes the corporate structure of the Group as at May 31, 2021:


                                                                                                                                                               Ningbo
                                                                             CITIC M&A                                                                                             Beijing Duotai               Onshore
                                                                                                                             Pharmaron                      Longtaikang
                                                                                Fund               Legend Capital                                                                    Investment                 Employee               A Share Public           H Share Public
                                                                                                                              Holdings        Mr. LOU        Investment
                                                                             Management              Co., Ltd.                                                                      Management                   Holding                Shareholders             Shareholders
                                                                                                                              Limited                       Management
                                                                               Co., Ltd                                                                                               Co., Ltd.                 Vehicles
                                                                                                                                                              Co., Ltd.

                                                                                   23.37%                    9.03%                 12.29%           3.46%          3.46%                       2.61%                    1.78%                  27.13%                     16.87%




                                                                                                                                                            The Company




             100%                                                                                            100%                                                                     100%                       100%                                           100%                                          68%               55.56%
                                                                                                                                                                              Pharmaron
                                                                                                     Pharmaron                                                                                                                                                                                       Beijing
                                                                                                                                                                           (Tianjin) Process             Pharmaron                                      Pharmaron                                                      Nanjing Sirui
        Pharmaron                                                                                   (Hong Kong)                                                                                                                                                                                     LinkStart
                                                                                                                                                                             Development                 Shanghai                                         Ningbo                                                       Biotechnology
         US, Inc.                                                                                   International                                                                                                                                                                                Biotechnology
                                                                                                                                                                            Manufacturing                 Co., Ltd.                                      Co., Ltd.                                                       Co., Ltd.
                                                                                                       Limited                                                                                                                                                                                     Co., Ltd.
                                                                                                                                                                               Co., Ltd.



              100%           100%                     100%                      100%                            100%                               100%                                                                       88.64%      11.36%             100%                    85%
                                                                                                                                                                                                                                 Pharmaron
                       Pharmaron                                           Pharmaron                     Pharmaron                            Pharmaron                                                                                                                     Pharmaron
                                                                                                                                                                                                                                  (Ningbo)          Pharmaron
        Pharmaron,   Biologics (UK)           Pharmaron UK                (Hong Kong)                       (UK)                               Biologics                                                                                                                     (Ningbo)
                                                                                                                                                                                                                                Technology         CRI (Ningbo)                                                                100%
           Inc.         Holdings                 Limited                  Investments                   Investments                         (Hong Kong)                                                                                                                      Biologics
                                                                                                                                                                                                                                Development          Co., Ltd.
                         Limited                                            Limited                        Limited                              Limited                                                                                                                      Co., Ltd.
                                                                                                                                                                                                                                 Co., Ltd.
                                                                                                                                                                                                                                                                                                                          Nanjing




161
                                                                                                                                                                                                                                                                                                                          Ximaidi
                                                                                                                                                                                                                                                                                                                         Medical
                                                                                                                                     80%                                                                                                                                                                                Technology
                             100%          100%                    100%                                         100%                                                                                                                               80%                      100%               100%                      Co., Ltd.
                                                                                                                                                      90%
                                                                                                                                                                                                                                             Hainan                   RAMED                Beijing
                       Allergan                                                                          Pharmaron                                                                                                                          Shenzhou                  (Beijing)            Sailebei
                                      Pharmaron              Pharmaron                                                        Pharmaron     10%                    100%                           100%                     100%
                       Biologics                                                                          (US) Lab                                                                                                                        Deshu Medical               Medical             Medical
                                      Japan LLC              ABS, Inc.                                                        CPC, Inc.
                        Limited                                                                         Testing, Inc.                                                                                                                      Technology                Technology          Technology
                                                                                                                                               Ningbo        Pharmaron                                                                      Co., Ltd.                 Co., Ltd.           Co., Ltd.
                                                                                                                                                                                      Pharmaron                  Pharmaron
                                                                                                                                             Pharmaron        (Beijing)
                                                                                                                                                                                        Xi’an                    Shaoxing
                                                      100%                                                      100%                          Biologics     TSP Services                                                                                                   100%                           100%
                                                                                                                                                                                       Co., Ltd.                  Co., Ltd.
                                                                                                                                              Co., Ltd.       Co., Ltd.
                                                                                                                                                                                                                                                                      Shanghai                      Beijing
                                                 Quotient
                                                                                                                                                                                                                                                                      RAMED                        Kangsida
                                                Bioresearch                                              Absorption
                                                                                                                                                                                                                                                                       Medical                      Health
                                             (Radiochemicals)                                           Systems LLC
                                                                                                                                                                                                                                                                     Technology                   Management
                                                  Limited
                                                                                                                                                                                                                                                                      Co., Ltd.                    Co., Ltd.

                                                                                                                            100%
                                                                                                   100%                                                                                                                                                                                                       100%             100%             100%

                                                                                                                                                                                                                                                                                                                                           Shanghai
                                                                                             Absorption               Absorption                                                                                                                                                                                        Beijing Xirui
                                                                                                                                                                                                                                                                                                      CR Medicon                              Ruixi
                                                                                               Systems                 Systems                                                                                                                                                                                         Biotechnology
                                                                                                                                                                                                                                                                                                      Research, Inc.                     Biotechnology
                                                                                            California LLC            Boston LLC                                                                                                                                                                                          Co., Ltd.
                                                                                                                                                                                                                                                                                                                                           Co., Ltd.
Our Platform and Integrated Solutions

We are a leading fully-integrated pharmaceutical R&D service platform with global operations. Since our
inception, we have successfully evolved from a pure chemistry service provider through drug discovery, to
a fully integrated contract research, development and manufacturing organization, providing services across
scientific disciplines covering the entire spectrum of drug discovery and development. In addition,
leveraging our comprehensive service offerings, we provide integrated and customized solutions to
pharmaceutical and biotech companies throughout the entire pharmaceutical R&D process.

The pharmaceutical R&D process mainly consists of four stages: (i) drug discovery, (ii) preclinical
development, (iii) clinical development and (iv) commercialization. Our integrated solution combines
pharmaceutical R&D services under three major service segments: laboratory services, clinical
development services and CMC (small molecule CDMO) services. Our laboratory services primarily cover
various scientific functions and disciplines for drug discovery and preclinical development stages; our
clinical development services primarily cover various scientific functions and disciplines for clinical
development stage; and our CMC (small molecule CDMO) services primarily cover the preclinical, clinical
and commercial manufacturing stages.

We have established our leadership in drug discovery and early-stage clinical development, while we
continue to expand our capabilities in late-stage clinical development and commercial manufacturing.
Through our end-to-end service platform, we serve the needs of our diverse, expanding global customer
base, which ranges from large multinational pharmaceutical companies to venture-backed start-ups and
virtual biotech companies. We provide our customers with world class services, customized solutions and
state-of-the-art technical capabilities, enabling them to advance research projects and clinical studies in an
accelerated format and potentially reduce associated R&D costs and risks, to relieve the need to invest
significant resources to develop their in-house capabilities and to improve overall efficiency throughout the
drug discovery and development process.

The chart below illustrates our key service offerings in each stage of the pharmaceutical R&D process:



                             Discovery               Pre-clinical                 Clinical           Commercial

                            Laboratory chemistry
                            DMPK / ADME
             Laboratory
                            In vitro biology and in vivo pharmacology
              Services                              Safety assessment
                            Discovery biologics
                                                    CGT product evaluation


             CMC (small                              Process development and manufacturing
              molecule                               Material science / pre-formulation
              CDMO)                                  Formulation development and manufacturing
              Services                               Analytical development


                                                                        Clinical research services
              Clinical                                                  Site management services
            Development
              Services                               Regulatory bioanalysis services
                                                     Radiolabelled sciences




Laboratory Services

Our laboratory services primarily include laboratory chemistry, DMPK/ADME, biology services, safety
assessment and discovery biologics services that primarily focus on the discovery and development of small
molecule drugs. As of December 31, 2020, we had 5,685 employees under our laboratory services segment.
Our laboratory services segment contributed to 65.2%, 63.3% and 63.6% of our revenue for the years ended
December 31, 2018, 2019 and 2020, respectively.


                                                             162
Laboratory Chemistry

We provide efficient and innovative chemistry services in support of customers’ medicinal chemistry and
drug discovery research. With the leadership of an experienced synthetic and medicinal chemistry
management team, we employ nearly 4,000 chemists designing and synthesizing compounds to meet the
needs of our partners in a timely and cost-effective manner.

Medicinal Chemistry

Our medicinal chemistry services support our customers’ needs for hit identification (HI), lead generation
(LG) and lead optimization (LO) programs, including novel scaffold design for hit identification,
preliminary intellectual property (IP) analysis of newly designed scaffolds, synthesis of focused libraries
for LG and LO, structure-activity relationship analysis based on in vitro and in vivo data, computer-aided
drug design (CADD) and diversity analysis, non-cGMP scale-up to support in vivo efficacy and toxicity
studies, patent application preparation, recommendation of appropriate DMPK and in vitro toxicology
studies to help key compound advancement, and project management.

Using CADD, our modeling team constructs and analyzes models of small molecules to address questions
encountered in the progression of drug discovery projects regarding potency, selectivity and metabolic
stability. The CADD team uses an array of computational tools and resources and works closely with our
partners’ chemistry team, as well as our own chemists and structural biologists.

Synthetic Chemistry

Our organic chemistry services design synthetic routes and prepare targets in milligram to kilogram scales.
We are able to organically synthesize novel compounds with complex structures, perform chiral chemistry
via asymmetric synthesis, optical resolution, chiral separation (high- performance liquid/supercritical fluid
chromatography), bio-organic chemistry including nucleosides and nucleotides, carbohydrates, peptides,
lipids and antibody-drug conjugates, library synthesis of diversity compound collections or those designed
for specific targets, and DNA-encoded library synthesis.

To support our partners’ efforts to expedite the drug discovery process, we have assembled world-class
capacity in routine library and DNA-encoded library synthesis. Our experienced library teams are capable
of efficiently validating synthetic routes and carrying out library synthesis. The laboratories at Pharmaron
are equipped with all necessary modern instruments including synthesizers, microwave assisted reactors,
automated HPLC and mass spectrometry-based purification systems, liquid chromatography-mass
spectrometry and nuclear magnetic resonance spectroscopy, compound management and plating systems.

In addition, our discovery process chemistry team has a proven track record of providing advanced
intermediates and active pharmaceutical ingredient scale-up. Our team supports programs from late-stage
lead optimization, facilitating candidate selection through preclinical development. We provide a wide
range of services that enable rapid development of candidate compounds to accelerate programs to key
preclinical milestones. Route design/synthesis services provided by Pharmaron include designing new
routes for complex targets, applications of the latest synthetic methodology and catalytic and asymmetric
approaches. Optimization of existing synthetic routes includes reaction screening, statistical approaches in
experiment design and intermediate stability studies. Compound purification and isolation improvement
services include the development of robust isolations, physical form monitoring, classical resolutions and
impurity isolation and identification. Pharmaron’s process safety evaluation services include generation and
interpretation of data to ensure safe scale-up, a suite of techniques used to provide robust data readouts, and
reaction calorimeter, adiabatic calorimetry, differential scanning calorimetry and power compensation
calorimetry.




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Discovery Analytical Chemistry and Purification Sciences

Our analytical chemistry services provide analytical services to support library chemistry, medicinal
chemistry, synthetic chemistry and discovery process chemistry programs. The analytical and purification
team at Pharmaron, equipped with state-of-the-art instruments, provides services specialized in chiral and
achiral separation and purifications, such as those listed below:

     Analytical method development for chiral separations;

     Chiral separation from milligram to multi-kilogram scale;

     Achiral and chiral supercritical fluid chromatography purification and crude sample purification;

     High-throughput quality control and purification for library compounds, including DNA-encoded
     libraries;

     Compound characterization and authentic material characterization;

     Genotoxic impurity method development;

     Ion analysis by ion chromatography;

     Metal method development and analysis by ICP-OES and ICP-MS;

     Structure confirmation studies and elemental analysis;

     Impurity structure elucidation studies; and

     Nuclear magnetic resonance spectroscopy (NMR) and quantitative NMR services for structure
     elucidation of isolated impurities by acquisition and interpretation of comprehensive 1D/2D NMR
     data.

DMPK/ADME

We provide high-quality DMPK/ADME services to support drug discovery and development programs from
early discovery stages through IND submission. The DMPK/ADME services offering which integrates with
laboratory chemistry, CMC (small molecule CDMO), in vivo pharmacology and safety assessment, assists
customers in successfully identifying preclinical candidates and preparing IND applications.

We offer comprehensive in vitro ADME, in vitro toxicity and in vivo DMPK services that allow for the rapid
evaluation of the DMPK properties and toxic potential of test compounds. The team performs screening
assays covering a broad spectrum of in vitro ADME studies to support discovery and preclinical needs, with
data types including solution properties, permeability, enzymatic stability and drug-drug interaction
potential.

We also offer in vivo DMPK, toxicokinetics (TK) and formulation analysis services to support drug
discovery and the preclinical development for small molecules, peptides, nucleosides/nucleotides and
biologics. The in vivo DMPK team working together with in vivo pharmacology team conducts PK/PD
studies to help confirm the exposure levels of a test compound, metabolites and biomarkers in systemic
circulation, excreta and tissues, particularly target organs, while assisting in understanding the correlation
between a test compound’s exposure and its PD effects using diseased or healthy animal models.



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Meanwhile, we conduct DMPK studies to support the preparation of comprehensive IND filing DMPK
package that meet FDA, NMPA and EMA regulatory requirements. The DMPK package includes
comprehensive in vitro and in vivo ADME profile of the test article – a preclinical candidate.

In addition to our IND filing package services, we provide GLP/GCP-compliant analytical and bioanalytical
services to support preclinical to clinical studies for small molecule drugs, biologics and vaccines, from API
pharmacokinetics to PD biomarkers and from mass balance studies on rodents by quantitative whole-body
autoradiography to clinical metabolism and absolute bioavailability studies by micro-dosing of a
radiolabelled API in human.

in vitro Biology and in vivo Pharmacology

We provide in vitro biology and in vivo pharmacology services to support drug discovery and development
programs. Our services cover major therapeutic areas such as oncology, cardiovascular and metabolic
diseases, neuroscience, inflammation/pain management and immunology.

in vitro Biology

Our in vitro biology services support drug discovery and development to help our partners succeed in target
validation, hit identification, hit-to-lead, lead optimization and selection of preclinical candidates. Our
scientists and technicians are experienced in biochemistry, cell biology, high throughput screening (HTS),
structural biology, electrophysiology and protein engineering, and have expertise in key therapeutic areas
including oncology, immuno-oncology, metabolic disorders, immunology, inflammation and neuroscience
and pain management. The in vitro biology services are described in more detail below.

     in vitro Screening. Our in vitro screening center is designed to advance novel compounds from
     early-stage discovery to the clinical development stage, with capabilities including HTS, assay
     development, primary, secondary/cellular, selectivity and in vitro safety pharmacology screening and
     studies of mechanism of action. We have target-based screening platforms covering enzymes,
     ion-channels, G-protein- coupled receptors (GPCRs) and nuclear receptors to support discovery
     programs. The in vitro safety pharmacology screening covers kinases, GPCRs, nuclear receptor and
     ion channel panels.

     in vitro Disease Biology. Our in vitro disease biology team works closely with our customers on
     specific projects, including evaluating biological targets, developing and validating assays, screening
     compounds and providing project-tailored work flows to meet project-specific goals.

     Structural Biology. Our structural biology team provides services in protein expression, purification
     and crystallization, crystal structure determination and analysis of macromolecule and small molecule
     complexes. The structural information will help biologists to understand the mechanism of action of
     the biological target in signal transduction pathways and also provide the computational chemists with
     the structural information to facilitate the modeling work in design of novel compounds.

     Compound Management System. Our compound management system is a tailor-made, automated
     system that stores, archives and handles compounds in either solid or solution format. The system is
     composed of a high-throughput liquid/plates handling platform and a secured sample storage platform,
     complemented by sophisticated data management and processing software. It supports the assays
     needed by in vitro biology and in vitro ADME, with high precision, accuracy and reproducibility.




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in vivo Pharmacology

Our in vivo pharmacology services consist of in vivo and ex vivo pharmacology services in therapeutic areas
of oncology, cardiovascular and metabolic disorders, inflammatory diseases, central nervous system (CNS)
diseases and pain. Our scientists and technicians possess significant experience in disease model
establishment and validation for efficacy screening, in vivo pharmacology profiling, PK/PD and mechanism
of action studies and customized studies, and are supported by our internal PK/bioanalytical, ex vivo
pharmacology and in vitro biology teams as part of our integrated service offering.

The ex vivo analysis of samples derived from in vivo study animals is to confirm the in vivo effect of test
articles and to identify the correlation between in vivo efficacy and biomarkers. With data for test article’s
exposure in animals, conducted by our DMPK and in vitro biology teams, a PK/PD correlation could be
established to better understand the test article’s behavior in vivo.

Safety Assessment

We provide comprehensive, GLP-compliant safety assessment services to support discovery programs as
well as regulatory filings with the FDA, NMPA and EMA. The evaluation of the safety of new drug
candidates includes general toxicology, safety pharmacology, genetic toxicology, developmental and
reproductive toxicology (DART) to immunotoxicity and immunogenicity in support of customers’ IND and
NDA submissions at our international GLP-compliant and AAALAC-accredited safety assessment facility.
Our safety assessment services primarily cover:

     General Toxicology. We help our partners plan and conduct general toxicology studies to support
     pharmaceutical development programs in small molecule drugs, biologics, cell and gene products,
     herb medicines and medical devices. The types of studies that we conduct include acute/single dose,
     sub-chronic and chronic studies, in both large and small animal species, which can be performed in
     a GLP compliant manner to meet regulatory submission requirements.

     Safety Pharmacology. We offer core battery safety pharmacology studies in both large and small
     animal species, either as a stand-alone study or incorporated within broader toxicology studies, on the
     central nervous system, cardiovascular system and respiratory system. These studies can be performed
     in a GLP compliant manner to meet regulatory submission requirements.

     Genetic Toxicology. Our genetic toxicology services provide genotoxicity screening assays for
     discovery programs and standard GLP genotoxicity assays to establish compliance with regulatory
     guidelines for regulatory submission purpose.

     DART. Our DART services are for evaluating developmental and reproductive toxicity of various
     types of test articles, particularly pharmaceutical agents. The studies can be performed in a GLP
     compliant manner to meet regulatory submission requirements.

     Pathology. Our pathology services provide pathologic assessments and interpretations including
     clinical pathology, necropsy, histology, and histopathology, to support tox studies in a GLP compliant
     manner.

     Immunotoxicity and Immunogenicity. Our technology platforms include immunochemistry,
     immunohistochemistry, flow cytometry, heat-mediated enzyme-linked immunosorbent assay
     (HELISA), real-time PCR (qPCR) and next generation sequencing platforms, through which we are
     able to help our customers evaluate a wide range of test articles, including antibodies, recombinant
     proteins and siRNA.

     Bioanalytical Sciences. We provide bioanalytical services in support of safety assessments of small
     molecule drugs and biologics, cell and gene products, and herb medicines including method
     development and validation, dose formulation analysis, bioanalysis of preclinical samples, in a GLP
     compliant manner.


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Discovery Biologics

Our discovery biologics services focus on cell line development, antibody/protein engineering, Fc-fusion
proteins, antibody humanization, recombinant antibody production, protein expression, purification and
characterization. We have extensive experience in various protein expression systems and are capable of
purifying recombinant proteins from various cells or native proteins from animal organs or tissues. We are
also experienced in preparation of ADCs and pegylation of proteins post-protein expression. With these
capabilities, we can help discover and re-engineer novel antibodies/proteins for therapeutic purpose and
also provide special cell lines and antibody/protein to support in vitro biology and in vivo pharmacology
project needs.

U.S. Laboratory Services

To further strengthen our fully-integrated services platform and continue to expand our global footprint, we
acquired Absorption Systems in November 2020 and launched U.S. laboratory services through such
acquisition. Our U.S. laboratory services mainly include DMPK/ADME and bioanalysis for both small
molecules drugs and biologics, particularly in transporters, human PK prediction and translational
pharmaceutics. With our global network of laboratory services capabilities, we will further strengthen and
consolidate its leading position in discovery and development DMPK platform. In addition, our U.S.
laboratory services also include drug evaluation services for cellular and gene therapy (CGT) products and
laboratory services in the areas of ophthalmology and medical devices.

Clinical Development Services

Our clinical development services include clinical research, regulatory bioanalysis, radiolabeled sciences
and site management services. With our capability to provide clinical development services in the U.S., the
U.K. and China, we are able to meet the customized needs of our domestic and international partners. We
can also file investigational new drug (IND) applications for their drug candidates with regulatory
authorities in China, the U.S. and Europe in parallel. In 2020, we submitted 58 IND applications for our
pharmaceutical and biotech customers in China, among which 46 were IND applications targeting multiple
jurisdictions (include China, the U.S. and EU), which demonstrated the advantage of and strong demand for
our total solution approach. As of December 31, 2020, we had 2,208 employees under our clinical
development services segment. Our clinical development services segment contributed to 11.9%, 12.1% and
12.3% of our revenue for the years ended December 31, 2018, 2019 and 2020, respectively.

Clinical Development Services Offered by Our Overseas Subsidiaries

Through our overseas subsidiaries in the U.S. and the U.K., we provide clinical research, bioanalysis and
radiolabeled services to our customers.

U.S. Clinical Research Services

Our clinical research center in Baltimore specializes in integrated FIH, Thorough QT/Early Phase QT,
human abuse potential and Chinese/non-Chinese ethnobridging studies, with a therapeutic focus on
infectious disease, CNS, dermatology, metabolism and respiratory diseases, to conduct Phase I and II
clinical trials in support of clinical development. In addition, the clinical center can also conduct
14
   C-microdosing and 14C-macrodosing to support clinical PK and metabolism studies, using AMS and
liquid scintillation counting (LSC) analytical platforms.




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Our services primarily include:

     First-in-Human (FIH) study. While the clinical research center offers services to conduct routine FIH
     study, evaluating innovative investigational drugs’ safety, tolerability, PK and food effect, we can
     incorporate multiple objectives into a single Phase I protocol, to answer specific questions in FIH
     studies include complex drug delivery, adaptive designing including dose level and formulation
     development, QT de-risking, thorough QT investigation, ethnobridging study, PD assessments and
     studies for early proof-of-concept. 14C-microdosing and 14C-macrodosing for absolute bioavailability
     and metabolism studies can be incorporated into the FIH study, or as separate studies.

     Single-site Phase II Studies. Through our established network of local academic sites, hospitals and
     private practice physicians, we utilize Pharmaron’s clinical center in Baltimore as a single data
     collection center, which is fed by many recruitment centers. The use of a single site for data collection
     yields consistent, high-quality data collection and reporting.

All the analytical studies associated with the clinical studies are carried out in our designated analytical labs
for bioanalysis of small molecule and biologic samples, biomarker analysis and clinical pathology tests.

Regulatory Bioanalysis Services

All the analytical studies associated with the clinical studies are carried out in our designated analytical
laboratories for bioanalysis of clinical samples of small molecule and biologics, and biomarker analysis and
clinical pathology tests. Our clinical bioanalytical team aims to develop and validate reliable and robust
bioanalytical methods and to provide high-quality bioanalytical services with high levels of data integrity
and GCP compliance to meet the requirements of major global regulatory authorities (such as the FDA,
NMPA and EMA). We provide bioanalysis services for small molecules and biologics:

     Bioanalysis of small molecules: Our small molecule bioanalysis team conducts method development,
     method validation, quantitative analysis for API and metabolites of small molecules and small
     molecule-based biomarkers, using HPLC and LC/MS/MS analytical tools for quantitative analysis to
     support the clinical trials.

     Bioanalysis of biologics: Our biologics bioanalysis team performs method development, method
     validation, quantitative analysis for biologics, including biomarker analysis using mesoscale
     discovery, Gyros HELISA, qPCR and flow cytometry and other techniques to support the clinical
     trials.

     Bioanalysis of 14C-API and 14C-metabolites: Our isotope bioanalysis team carry out 14C- or 3H-
     material method development, method validation, quantitative analysis for 14C- or 3H-API, 14C- or
     3
       H-metabolites, 14C- or 3H-biologics, using either AMS and/or LSC analytical tools to support the
     isotope related clinical studies.

The global presence of our bioanalytical capability (in China, the U.S. and the U.K.) makes our bioanalysis
platform readily available to clinical research centers globally, which enables us to accelerate the clinical
development process for our customers.




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Radiolabelled Sciences

Our experienced synthetic chemists, analytical chemists and drug metabolism scientists help our customers
synthesize 14C and 3H radiolabeled compounds to study their absorption, distribution, metabolism,
excretion and fate of a wide variety of compounds in clinical, preclinical and discovery investigations.

Radiolabelling/Radiosynthesis

Our radiochemistry specialists provide expert advice on radiosynthesis, preparation and release of
radiolabeled test compounds for use in non-clinical and clinical drug development and in environmental fate
studies. With our years of dedication in the radiochemical synthesis field, our cGMP- and/or GLP-compliant
state-of-the-art laboratory facilities have made approximately 40,000 14C labelled and approximately
10,000 3H labelled molecules. We offer complete management of the radiosynthesis process, from labelling
position selection, optimizing radiosynthetic pathways, final product analysis to re-purification and
recycling options.

We also offer covalent radiolabeled/radiotagging techniques with 3H and 14C for biologics. Our AMS
analytical platform can analyze 14C-material in an ultra-sensitive manner, allowing ultra-low abundance of
14
   C-materials to be analyzed with high accuracy, precision and reproducibility to meet the GCP/ICH
guidelines for regulatory submission. By employing our AMS analytical platform, we provide services to
analyze 14C-materials in samples taken from clinical and non-clinical studies. This high sensitivity
analytical platform allows 14C-microdosing or 14C-microtracer approach in clinical studies to become
available. Our team including AMS specialists and clinical experts helps design 14C-microtracer included
clinical studies, such as absolute bioavailability in human and clinical metabolism studies. Our clinical and
AMS teams design and execute the study plans following GCP/ICH guidelines to ensure high quality of data
and data integrity.

We also provide services using other conventional analytical tools to conduct analysis of 14C/3H-labelled
materials in samples taken from clinical studies, to answer questions associated with clinical metabolism,
following GCP/ICH guidelines for regulatory submission. These conventional analytical tools include LSC
platform, which, more than often, meets the needs for clinical metabolism study using 14C/ 3H-macrodosing
approach.

AME Study of Radiolabelled Compounds

We provide comprehensive services to support 14C radiolabeled studies in humans. Together with our
clinical research team, our integrated solutions include 14C radiosynthesis of compounds suitable for human
administration, mass balance, metabolite analysis (metabolite profiling/identification), drug-drug
interaction and PK for traditional high-radioactive dose studies using LSC analysis. We also support
low-radioactive dose studies (microtracer and microdose) employing clinical protocols using nCi tracer
doses of radioactivity in humans with ultra-sensitive AMS analysis for clinical metabolism and absolute
bioavailability studies.

Clinical Development Services Offered by Our PRC Subsidiaries

Primarily through CR Medicon and Beijing LinkStart, our subsidiaries in China, we provide clinical
research, bioanalysis and site management services to our customers.




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China Clinical Research Services

We provide clinical research services in China through our subsidiary CR Medicon, a full-service clinical
CRO established in 2017 and located in Nanjing, China. Our clinical research services provided through CR
Medicon primarily include:

     Regulatory and Registration. Our team provides services for IND and NDA registration for small
     molecule drugs, biologics and medical devices for domestic and foreign pharmaceutical companies.

     Medical Affairs. We provide medical affairs service to develop optimal clinical development plans,
     providing high-quality clinical trial design and draft as well as preparation of registration dossier. The
     medical monitoring team focuses on medical monitoring services for clinical research.

     Clinical Operation. Our clinical operation service covers Phase I-III, bio-equivalence and medical
     device clinical studies. As a basis of our complete project management process, we have on-site
     auditors in approximately 100 cities across China to assist in monitoring clinical trials, to ensure that
     the clinical studies are conducted under GCP/ICH guidelines and data integrity is intact and ensure
     the smooth implementation and timely completion of the project.

     Data Management and Statistical Analysis. Our data management and statistical specialists strictly
     implements the CDISC rules, follows the GCP guidelines and our internal and customers’ standard
     operating procedure (SOP) workflows, and design custom solutions based on sponsors’ requirements.
     From protocol design to the entire project management, we provide flexible and convenient services
     that ensure smooth and unobstructed communications between regulatory authorities and researchers.

     Pharmacovigilance. We provide pharmacovigilance solutions, including IND-filing needed
     information on the establishment of pharmacovigilance system, safety management plan, the
     individual case safety report (ICSR), and drug safety update reports (DSUR).

Regulatory Bioanalysis Services

The regulatory bioanalysis services provided by our subsidiaries in China are similar to those provided by
our overseas subsidiaries as described above, and all the analytical studies associated with the clinical
studies are carried out in our designated analytical laboratories for bioanalysis of small molecule and
biologic samples, biomarker analysis and clinical pathology tests.

Site Management Services

We provide site management services (SMO), which include site feasibility, site initiation, patient
recruitment, patient management, data entry and document management, on-site drug management and
bio-sample management till site closure. In order to provide our customers with fully integrated clinical
development services, we acquired LinkStart in June 2020 which specializes in clinical site management
services (including CRC services, hospital selection, study start-up (SSU), rapid start-up, recruitment and
management, quality assurance and training and post-marketing studies) which further enhances the quality
and efficiency of the clinical research services. As of December 31, 2020, LinkStart has approximately
1,500 clinical research coordinators and has established stable and long term collaboration relationship with
over 600 national clinical research centers across China. LinkStart is particularly experienced in conducting
clinical research for major therapeutic areas such as oncology, endocrinological diseases, cardiovascular
diseases, infection and immune rheumatoid diseases. As of December 31, 2020, LinkStart has conducted
over 1,000 clinical studies, of which approximately 85% are innovative drugs and biological products.




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CMC (small molecule CDMO) Services

Our experienced CMC (small molecule CDMO) service team delivers customized and cost-efficient
solutions to drug development and manufacturing, including process development and manufacturing,
material science/pre-formulation, formulation development and manufacturing, and analytical development
services to support pre-clinical, clinical development and commercial manufacturing. As of December 31,
2020, we had over 1,900 employees under our CMC (small molecule CDMO) services segment and had 739
ongoing projects in different drug R&D stages, among which 487, 202, 47 and three were in pre-clinical,
Phase I/II, Phase III and commercialization stages, respectively. Our CMC (small molecule CDMO)
services segment contributed to 22.2%, 24.0% and 23.8% of our revenue for the years ended December 31,
2018, 2019 and 2020, respectively.

The quality assurance system of our CMC (small molecule CDMO) services has passed numerous quality
audits by large international pharmaceutical and biotech companies and is in compliance with all applicable
regulatory requirements. Our cGMP API and drug product manufacturing facility are qualified for
manufacturing products to support clinical trials in key global markets, such as the United States, China and
the EU. Our quality assurance system follows ICH guidelines and supports API and drug product
development and manufacturing in compliance with cGMP requirements promulgated by the FDA, NMPA
and EMA. It also provides support for the preparation of full regulatory data packages and documentation
sets for regulatory filings and cGMP audits by customers in the United States, the EU and Asia.

We continue to invest on cutting-edge technologies of small molecule to provide value-added process
optimization and manufacture services to domestic and foreign customers to meet their needs at different
drug development stages. In providing CMC (small molecule CDMO) services, we have practiced the
concept of green chemistry and vigorously applies new technologies such as flow chemistry and
biocatalysis to develop safer and more efficient chemical processes for the customers. In addition, the
chemistry team has further strengthened the competitive advantage of CMC (small molecule CDMO) full
service jointly with the teams of material science, crystallization R&D and formulation. In terms of R&D
and manufacturing capacity, the we have facilities in Tianjin, Shaoxing, Ningbo and the U.K., and will
continue to increase capacity to provide customers with services that consistently meeting their global
quality standards and production requirement. In terms of customer services, leveraging on the integrated
services platform and the technical experience accumulated over the years, our development and
manufacturing services get involved at the early stage of the drug development projects and the solid
foundation of the early stage projects has paved the way for the development of our commercial
manufacturing business.

Process Development and Manufacturing

Our process chemistry specialists provide a broad range of services in our China and UK facilities for API
development, from preclinical through NDA, as described below.

     Discovery and development of new and existing synthetic routes, fit-for-purpose optimization and
     scale-up from preclinical to NDA;

     Polymorph and salt/co-crystal screening for selection of an appropriate solid form for API
     development;

     Crystallization of API and intermediate for process development;

     Development of synthetic routes and scalable processes for complex organic molecules and APIs, such
     as macrolides, nucleotides and nucleosides, including those with synthetic sequences with over 20
     steps;

     Definition and study of critical process parameters to support validation of chemical processes for the
     cGMP or non-cGMP production of APIs; and

     Discovery and development of cost-effective, safe and environmentally friendly synthetic routes for
     the commercial production of intermediates and APIs from kilograms to tons scales.


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In addition, we provide manufacturing services for the development and production of small-molecule APIs
at our facilities in China and the UK. Our multi-purpose cGMP kilo lab, pilot plants and manufacturing
plants are capable of handling advanced intermediates and complex APIs. These facilities are equipped with
glass-lined/stainless steel and hastelloy-alloy reactors with sizes ranging from 20–8,000 L.

We have successfully delivered multiple complex APIs with synthesis requiring more than 20 linear steps,
involving asymmetric hydrogenations, air- and moisture-sensitive reactions, transitional metal catalysis
reactions, high and low temperatures, high pressure and oxidations/reduction reactions. In both our China
and UK facilities, we have completed hundreds of cGMP APIs to support Phase I-III clinical trials in the
United States, China and Europe.

Material Science and Pre-Formulation

Our material science team provides services for discovery support and solid-state chemistry to solid form
screening, process development and early formulation development, including drug discovery support for
initial compound CMC profiling and preclinical formulation, pre-formulation of development candidates,
polymorph and salt/co-crystal screening for solid form selection, crystallization processes of intermediate
and API, control of polymorph and particle size and solid state and physicochemical analysis tailored to
compound/material characteristics.

Formulation Development and Manufacturing

Our formulation development team designs, modifies and prepares formulations for oral administration,
such as tablet, capsule, solution and suspension, to support preclinical, clinical and commercial needs.

Our cGMP facility manufactures clinical test materials for clinical trials, such as oral liquids and oral solid
dosage forms with batch sizes up to 140 kg, and employs conventional technologies including wet
granulation, roller compaction, encapsulation, tablet compression, film coating, bottle packaging and blister
packaging, and enabling technology, including spray drying and wet milling.

Analytical Development

Our analytical chemists provide comprehensive analytical testing support for process development and the
manufacture of drug substances and drug products. Our analytical team adheres to regulatory guidance on
supply chain assurance for quality control. Our analytical capabilities include analytical method
development and validation and quantitative analysis of drug substances, drug products and impurities
which are used to obtain the critical information as below to meet the regulatory submission requirement:

     Reference standard characterization and qualification;

     ICH stability studies for drug substances and drug products;

     Impurity identification, characterization and profiling;

     Genotoxic impurity method development and validation;

     Genotoxic impurity lot analysis and issuing Certificate of Analysis (COAs);

     Trace metal method development and analysis;

     cGMP batch release testing for drug substances, drug product and issuing COAs;

     Process control strategies and analytical QC manufacturing support;

     cGMP NMR services for process support and quantitative NMR for API quantification studies;

     Formulation solubility, dissolution, disintegration and permeability studies; and

     Microbial limit tests and issuing COAs.


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Integrated Services

Our integrated drug discovery services team, based in the U.K., the U.S. and China, leads small molecule
drug discovery projects for our customers from hit identification to candidate selection. Services provided
by our integrated drug discovery service team include CADD, medicinal and synthetic chemistry,
DMPK/ADME, in vitro biology, in vivo pharmacology, safety assessment and discovery process chemistry
to support the entire drug discovery process, delivering preclinical candidates. In addition, together with our
IND-enabling service platform, we provide integrated services to enable IND application generation under
GLP/ICH guidelines, which include DMPK, in vivo pharmacology, safety assessment, CMC and clinical
plan, for IND submission to regulatory authorities such as FDA, NMPA and EMA.

In addition, we have a proven track record of offering customized integrated solutions beyond geographic
boundaries. For example, our highly experienced drug discovery team based in U.K. works closely with our
technical teams in China to provide a unique service model to meet our customers’ needs by fully utilizing
the strengths of our U.K. and China teams to accelerate the drug discovery process for our customers. Our
clinical pharmacology team in the U.S. has worked seamlessly with our China team to conduct FIH studies
in the U.S. after IND applications are prepared and submitted by the China team.

Our Customers

We have provided our services to over 1,500 customers worldwide since our inception. Most of our
customers are pharmaceutical and biotech companies, including many major global players. We have a
diversified customer base, with customers located in North America, China, Europe and the rest of the world
accounting for approximately 63.7%, 13.6%, 19.1% and 3.6%, respectively, of our revenue for the year
ended December 31, 2020. In addition to large pharmaceutical companies, such as the global top 20
pharmaceutical companies in 2020, we also provide comprehensive and customized services responding to
the needs of a growing group of diverse biotech start-ups and virtual pharmaceutical companies. In 2018,
2019 and 2020, we provided pharmaceutical R&D services to 846, 1,038 and over 1,500 customers,
respectively.

We are devoted to enhancing the breadth of our services and providing customized services to target
customers with unique needs and demands. We enjoy a high level of customer loyalty and have developed
solid working relationships with many customers. Many of our customers return to us for additional
projects, and our revenue generated from existing customers continued to increase. The total revenue
generated from our five largest customers increased from RMB718.1 million for the year ended December
31, 2018 to RMB794.3 million for the year ended December 31, 2019 and further to RMB963.7 million for
the year ended December 31, 2020. In 2018, 2019 and 2020, our five largest customers together accounted
for 24.8%, 21.1% and 18.8%, respectively, of our revenue, and our largest customer accounted for 5.7%,
5.3% and 6.0%, respectively, of our revenue.

Customer Services

We are devoted to providing our customers with world-class pharmaceutical R&D services. Through our
globally centralized business development team with solid scientific background, we deliver customer
services to our customers without geographic and service boundaries. We assign a dedicated team of
scientists and research technicians to each of our customers to provide better support. Our project team
actively interacts with a customer’s project-management team through emails, periodic reports and
conference calls. To facilitate project management, we have developed and maintain an online system
allowing a customer’s project manager to monitor and report on the progress of its projects.

Our commitment to high quality services helped us to expand our customer base via word-of-mouth
referrals. We conduct periodic customer satisfaction surveys with certain key customers, and use
measureable key performance indicators to improve our planning, execution, evaluation and support. In
addition, we benefit from our strategic partnership with selected customers. Through know-how sharing and
trainings provided during our deep collaboration with these customers, we were able to further improve our
technical capabilities and enhance our service excellence.


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Suppliers

Due to our comprehensive service offerings, we procure a wide variety of raw materials, such as experiment
reagents, and equipment. The raw materials and equipment are generally readily available in the market
through a number of suppliers in quantities adequate to meet our needs. We carefully select our suppliers
based on factors including their qualifications, product selection, quality, reputation, pricing, business
scale, technological strengths, quality management capabilities and overall services. In addition, we
regularly monitor and review the performance of our suppliers and conduct on-site audits for our key
suppliers on an as-needed basis. We have maintained stable relationships with many of our key suppliers.

We adopt a large-scale centralized purchase system for the regular purchase of raw materials commonly and
frequently used in daily research and development, production and operations. Our procurement team
manages the raw materials’ inventory level by monitoring the status of our ongoing projects and incoming
new projects and places orders with suppliers for any inventory that is expected to decline below targeted
levels. Our procurement team also procures raw materials and equipment in accordance with our business
expansion plan or to replace obsolete equipment on an as-need basis. We have established a complete
supplier management system. We monitor and manage suppliers by setting out new supplier selection
criteria and implementing a grading management system and evaluation criteria.

We seek to manage the impact of fluctuations in price of raw materials through various measures, such as
acquiring raw materials locally to minimize transport costs, managing our stock levels and purchasing
materials on consignment when necessary, and continuing to diversify and expand our supplier pool. We did
not encounter any material shortage or delay in the supply of raw materials. In 2018, 2019 and 2020, our
five largest suppliers together accounted for 12.4%,10.8% and 9.3%, respectively, of our total purchases,
and our largest supplier accounted for 3.1%, 2.5% and 2.3%, respectively, of our total purchases.

Quality Management

We believe that an effective quality management system for procuring raw materials, research and
development and manufacturing is critical to ensuring the quality of our services and maintaining our
reputation and success. We have established an in-house quality management system and devote significant
attention to quality control of raw materials and equipment and have adopted SOPs relating to quality
management. We seek to ensure that our services consistently meet high industry standards and
requirements. We have established a quality assurance department which is responsible for supervising the
implementation of our quality standards. Based on the research and development and specific
manufacturing processes of different products, we have established quality control measures for all stages
of our operations, covering procurement of raw and auxiliary materials, research and development and
process development, manufacturing of advanced intermediates and APIs and product quality disputes.

Quality System of Pharmaceutical R&D

Laboratory Services

We have developed SOPs for quality control (QC) for each technical function throughout the discovery
process. The SOPs tailored to each technical characteristics, ensure that every study has a QC process built
into the entire operation and research process, starting from the design of a study/project, material and
reagent supply, validation of instruments and equipment, execution of the study/project plan, method
development and validation, monitoring and/or verification of the execution process, raw data migration
and processing/presentation and storage, intermediates and final compound storage/shipping and report
writing to study/project closing, etc.

For studies that need to fulfill the regulatory requirement, such as GLP/ICH guidelines from FDA, NMPA
and EMA, in addition to the QC process as described above, our Quality Assurance Unit (QAU) works
independently and takes quality assurance (QA) measures to ensure that all the steps involved in the studies
will follow the GLP/ICH guidelines. SOPs related to QA have been well developed to allow QAU
inspection activities such as reviewing study protocols and amendments, conducting in-process inspections
for studies, auditing raw data generated by studies and reports, conducting facility inspections and auditing
vendors and study subcontractors, to ensure the GLP compliance.


                                                    174
Clinical Development Services

Our clinical development services include clinical research, SMO, regulatory bioanalysis and radiolabeled
sciences. All of these functions have established SOPs related to quality control covering all the important
steps involved in the clinical development process, tailored to each function’s characteristics, to ensure a
QC system is built into the entire operation and study process, and, so to ensure the high quality and
integrity of the clinical development study. Each function has established a Quality Assurance Department
in our clinical development services, in compliance with FDA, EMA and NMPA’s guidelines, with the goal
that the rights, safety and welfare of all study participants are protected.

While each team in every function has its own QC system established to monitor and verify the important
steps involved in a study, our QA system provides another layer of independent inspection of the important
activities in a study, so to ensure GCP/SOP/protocol compliance for the study. These activities include
protocol development/finalization, site inspection, healthy- volunteer and patient recruitment,
investigational drug management, clinical operation, pharmacovigilance, clinical pathology study,
bioanalysis of clinical samples, multiple-site management for clinical trial phases II/III/IV studies, data
management and biometrics, radiolabeled investigational drug synthesis/storing/shipping, regulatory
submission and registration. Our well-established QC and QA systems have passed numerous audits by our
sponsors and regulatory inspections by FDA, EMA and NMPA.

CMC (small molecule CDMO) Services

We have also developed GLP/GMP compliant standard operating procedures for quality control in our
manufacturing processes. We have established a quality assurance department to review the integrity of
each batch of products manufactured, in order to ensure that quality standards are maintained during the
manufacturing process. Quality supervisors take samples from each batch of products and laboratory
technicians carry out quality inspections on each batch of finished products and issue inspection reports
based on the results. Samples that fail to pass the inspection are disposed of in accordance with the
requirements of the operating procedures for substandard products. In addition, our quality supervisors are
also responsible for the monitoring and supervision of our workshops to ensure that the cleanliness
requirements of our facilities and the quality supervision of our manufacturing processes are maintained and
recorded in a faithful manner to ensure the traceability of product quality.

Quality System of Raw Materials and Equipment

We have adopted SOPs for our raw material and equipment procurement. For each of our projects, our
procurement team or our customer compiles a list of required raw materials in accordance with our internal
policies and procedures, as well as the quality systems required for the respective R&D services. We assess
the material risks associated with such raw materials and determine their specifications. We carefully select
raw material suppliers and conduct background checks on supplier candidates. Each step of our raw material
procurement is documented for our internal records as well as customer audits. During the three years ended
December 31, 2020 and up the date of this Offering Circular, we did not experience any material quality
issue relating to our raw materials.

In addition, we purchase equipment and spares only from selected reputable suppliers in accordance with
our internal policies and procedures. We conduct inspections and relevant testing on the incoming
equipment to ensure that the equipment is in satisfactory condition and fully functional before we accept
delivery from our suppliers. We also communicate with the technical and customer support staff of our
equipment suppliers regularly for the maintenance and upgrade of our equipment.




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Intellectual Property

As a pharmaceutical R&D service provider, our scientists and technicians are devoted to high quality R&D
services to our customers. In order to stay at the forefront of the industry and maintain our competitiveness,
we also invest in developing a number of proprietary technologies and service platform with an emphasis
on methodologies, processes, analytics, systems and other know-how to further enhance our R&D service
capabilities. While these technologies may not directly contribute significantly to our revenue, they further
expand our R&D capabilities and enhance our operating efficiency, thereby improving our competitiveness
in wining new business. As of December 31, 2020, we had 32 registered patents in China, six registered
patents in the United States, one registered patent in Japan and one registered patent in the European Union.
In addition, as of December 31, 2020, we had 95 registered trademarks in China (including one in Hong
Kong), four registered trademarks in the United States, three registered trademarks in the European Union,
two registered trademark in the United Kingdom, one registered trademark in Japan, one registered
trademark in Australia and 61 registered domain name.

Due to the nature of our services, we have access to a significant amount of intellectual property owned by
our customers. Our customers retain ownership of all intellectual property associated with their projects,
including the intellectual property that they provide to us and the intellectual property arising from the
services we provide. The protection of our customers’ intellectual property is critical to win customers’
trust. Protecting the proprietary rights of our customers has been a top priority since our inception. We enter
into agreements with all of our scientists and research technicians under which they assign all of the
intellectual property they create during their employment to us or our customers, as applicable, and waive
all relevant intellectual property rights or claims. All of our scientists and research technicians have agreed
to disclose and assign all inventions conceived by them during their term of employment.

Research and Development

As a pharmaceutical R&D service provider, we devote a substantial portion of resources to continuously
improving our scientific and technical capabilities through R&D projects with our customers. In addition,
we are committed to internal research and development of technological foundation, capabilities and
experience, which allows us to remain at the forefront of the latest technology trend in the pharmaceutical
industry, develop novel solutions for our customers in their drug discovery and development processes and
maintain our competitive position. We strive to further enhance our technical capability through internal
research and development, cooperation with universities and research institutions, collaboration with our
customers and development and improvement of the technologies acquired by us.

The newly established technology platforms developed through our internal R&D activities or
collaborations with top-notch academic laboratories help our customers to design their drug R&D programs
from new perspectives to accelerate their R&D processes. Meanwhile, during the process of conducting
these R&D activities, we have developed a R&D team which is highly capable of providing innovative and
value-added R&D solutions to our customers.

Our research and development process is carefully managed and allow us to maintain our leadership in the
marketplace. During the three years ended December 31, 2020, our research and development expense
amounted to RMB31.6 million, RMB62.9 million and RMB105.3 million for the years ended December 31,
2018, 2019 and 2020, representing 1.1%, 1.7% and 2.1% of our revenue in the same period.

Business Development and Marketing

We market our pharmaceutical R&D services directly to pharmaceutical and biotech companies through a
globally centralized business development team who are equipped with solid science background that are
dedicated to understand the demands of existing and potential customers and work closely with our
technical experts to prepare proposals and to secure customers. Our business development team interacts
with potential and existing customers regularly to better understand their scientific needs and development
strategies. During those meetings, we highlight the advantages of expediting the customer’s drug R&D
efforts through our flexible, end-to-end integrated drug research and development service platform.


                                                     176
Our business development team’s profound understanding of customers’ needs further enable us to provide
customized pharmaceutical R&D services. Leveraging our end-to-end service offerings, we are able to
cross-sell our services of different scientific functions to our customers and in the meantime offer our
comprehensive services covering the drug discovery and development stages as their pharmaceutical R&D
projects progress further. Customer referrals represent a large percentage of our new customer acquisition.
Since our inception, our senior management team continues to maintain direct relationships with our key
customers. In addition, we participate in trade conferences, trade shows and academic conferences.

Our business development and marketing specialists are strategically located in key pharmaceutical R&D
hotspots in China, the U.S. and the U.K., to conduct on-the-ground activities. As of December 31, 2020,
our business development and marketing team had 104 members.

Our Facilities and Offices

As of the December 31, 2020, we had 16 operation sites and branch offices, which include sites located in
Beijing, Tianjin, Xi’an, Nanjing, Shanghai, Shaoxing and Ningbo in China; Baltimore and Germantown,
Maryland, Exton, Pennsylvania, Boston, Massachusetts and San Diego, California in the U.S.; and Cardiff,
Rushden, Hoddesdon and Liverpool in the U.K.

Employees

As of December 31, 2020, we had a total of 11,012 employees, including 10,209 employees in China and
the rest of Asia, 436 in the U.K., and 367 in the U.S. As of December 31, 2020, we had 3,562 employees
who have obtained a master’s or higher degree, with 528 holding a Ph.D. or equivalent degree. For the years
ended December 31, 2018, 2019 and 2020, our revenue per scientist and technician was RMB545,921,
RMB586,965 and RMB522,397, respectively.

The table below sets forth a breakdown of our employees by function and by geography as of December
31, 2020:

                                                                       China and
                                                                      Rest of Asia            U.S.            U.K.             Total

Scientists and technicians..............................                      9,193                  288             346          9,827
Sales and marketing ......................................                       59                   36               9            104
Management and administration ....................                              957                   43              81          1,081
Total .............................................................        10,209                    367             436         11,012


The table below sets forth the respective numbers of our scientists and technicians by our business segments
at the end of each period during the three years ended December 31, 2020:

                                                                        December 31, 2018        December 31, 2019     December 31, 2020

Laboratory services ...........................................                       3,706                 4,301                 5,685
Clinical development services ...........................                               275                   556                 2,208
CMC (small molecule CDMO) services ............                                       1,346                 1,544                 1,934
Total scientists and technicians.......................                               5,327                 6,401                 9,827


We believe that our quality employees are the key to our success. In order to better attract, recruit and retain
quality employees. We provide our employees with opportunities to work on cutting-edge drug development
projects with world-class scientists, as well as opportunities to continued academic learning in our
Pharmaron College. As of December 31, 2020, we had 200 employees that completed trainings and visiting
scholar programs at Pharmaron College. We also aim to establish a collaborative work environment that
encourages them to develop their career with us. In addition, we have an effective training system, including
orientation and continuous on-the-job training, to accelerate the learning progress and improve the
knowledge and skill levels of our workforce. Our orientation process covers subjects such as corporate
culture and policies, work ethics, introduction to the drug development process, intellectual property
protection, quality management and occupational safety. Our periodic on-the-job trainings cover
streamlined technical know-how of our integrated services, environmental, health and safety management
systems and mandatory training required by applicable laws and regulations. In addition, we have adopted
an employee share incentive scheme to provide an additional means to attract, motivate, retain and reward
our employees.


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Competition

We face competition from other pharmaceutical R&D service providers, including CROs and CMOs. The
market in which we operate is highly fragmented and there are also a substantial number of small- to
medium-sized pharmaceutical R&D service providers, both multinational and locally based, which compete
for market share.

We face competition from pharmaceutical R&D service providers around the world. We compete with other
market players based on factors including quality and breadth of services, ability to protect our customers’
intellectual property or other confidential information, timeliness of delivery, ability to meet relevant
quality standards for different types of services such as GLP and cGMP, depth of customer relationships,
pricing and geographical coverage.

In terms of barriers to entry, the CRO and CMO services market generally requires high upfront costs and
time commitment, significant financial and time commitment in recruiting experienced talents, a successful
track record and a solid reputation in order to attract customers.

Our core competitive edge is our integrated service offering that covers the entire research and development
process, as well as our ability to provide our customers with an end-to-end service platform that saves
customers’ time and money. In addition, our sizable scientific team enables us to respond to our customers’
increasing demand and customized requests for external pharmaceutical R&D services in a timely manner.
We believe that we are able to maintain our competitiveness by leveraging our established position in the
global pharmaceutical R&D service market and capitalizing on the opportunities offered by the growing
pharmaceutical market in China.

Environmental, Social and Governance Matters

Attaching great importance to environmental, social and governance (ESG) management work, we
constantly promote the construction of ESG management system and improve our ESG management ability
and internal awareness of ESG work. We formulated a Corporate Social Responsibility Management
System, which stipulates that the general manager of our Company shall be responsible for leading the
fulfillment of social responsibilities, and our Social Responsibility Management Committee has also been
established to be responsible for the daily work related to corporate social responsibility.

Our Social Responsibility Management Committee adopted and is responsible for overseeing the
implementation of our measures and procedures to ensure our compliance with the applicable
environmental protection and health and safety laws and regulations and the health and safety of our
employees. These measures and procedures include (i) adopting protective measures at our facilities, (ii)
promulgating safety operation procedures relating to various aspects of our integrated services, such as the
use and storage of chemicals and operation of equipment, (iii) conducting safety training for all employees,
(iv) conducting regular safety and compliance inspections of our facilities, (v) engaging professional
waste-disposal companies to manage the disposal of hazardous and biohazardous waste, (vi) coordinating
third-party occupational health assessments and third-party fire safety inspections, (vii) overseeing the
safety of experiments through approvals of experiment plans and regular monitoring throughout the
experiments, and (viii) maintaining a system of recording and handling accidents and implementation of
relevant policies, and a health and work safety compliance record.

In the process of our production and operation, potential environmental risks include floor corrosion,
sewage overflow, waste leakage during transfer, and soil erosion caused by engineering construction, etc.
We have formulated systems and various internal policies to uniformly regulate our operations and
management as to plants’ rebuilding and expansion, chemical transportation and on-site sewage systems.
We have also strengthened inter-departmental cooperation and clarified personnel duties to avoid pollution
to nearby soil and groundwater, and advanced clean and green production operations. Generally, we had no
environmental accidents, and operated in compliance with applicable environmental laws and regulations
in all material respect.


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As our operations deal with a large amount of biochemical products and special equipment, we pay special
attention to the occupational health and safety of our employees. We constantly review and update our
internal work instructions and standard operating procedures to form a comprehensive safety operation
framework. In addition, we conduct employee safety training and emergency response trainings to respond
to various emergencies, in order to enhance employees’ risk awareness and self-rescue ability. In addition,
the Company pays attention to providing employees with safety protection products and enhancing their
awareness of protection by increasing safety propaganda, as well as improving records of dangerous goods
and assigning personnel to manage them.

Certifications, Permits and Licenses

We are required to obtain and renew certain certifications, permits and licenses in order to provide our
services. As of the date of this Offering Circular, we had obtained all of the material certifications, permits
and licenses that are needed for our operations, and all of such certifications, permits and licenses are within
their respective effective periods. We have not experienced any material difficulty in renewing such
certifications, permits and licenses. In addition, as of the date of this Offering Circular, we were not subject
to any administrative penalties relating to maintenance and renewal of our material certifications, permits
and licenses.

Insurance

We maintain the following types of insurance:

     Property insurance policies covering physical damage to, or loss of, our buildings and their
     improvements, equipment, office furniture and inventory;

     Employer’s liability insurance generally covering death or work-related injuries of employees;

     General commercial liability and professional errors and omissions insurance covering product
     liability claims arising from the use or consumption of our drug products, and claims arising from
     negligence in connection with our services to customers;

     Public liability insurance covering certain incidents involving third parties that occur on or in the
     premises of our Company; and

     Directors’ and officers’ liability insurance.

We do not maintain key-man life insurance on any of our senior management or key personnel, or business
interruption insurance. Our Directors consider that the insurance policies maintained by us are in line with
the industry norm in China and are sufficient to cover the potential losses and damages of our facilities.
While we believe that our insurance coverage is adequate, our insurance coverage may be insufficient to
cover any claim for product liability, damage to our fixed assets or employee injuries. Any liability or
damage to, or caused by, our facilities or our personnel beyond our insurance coverage may result in our
incurring substantial costs and a diversion of resources. Please refer to the paragraph headed “Risk Factors
– Risks related to Our Business and Our Industry – Our insurance coverage may not be sufficient” in this
Offering Circular.

Legal Matters

Legal Proceedings

We may from time to time be involved in contractual disputes or legal proceedings arising out of the
ordinary course of our business. To the knowledge of our Directors, we have not been subject to any claims,
damages or losses which would have a material adverse effect on our financial position or results of
operations as a whole. As of the date of this Offering Circular, no material litigation, arbitration or
administrative proceedings which would have a material adverse effect on our financial position or results
of operations as a whole had been initiated or threatened against us.


                                                       179
Legal Compliance

To the knowledge of our Directors, we have not had any non-compliance incidents which our Directors
believe would, individually or in the aggregate, have a material operational or financial impact on our
Company as a whole.




                                                 180
                                   RECENT DEVELOPMENT

In February 2021, Pharmaron Biologics (UK) Holdings Limited and Pharmaron (Hong Kong) International
Limited (both are our wholly-owned subsidiaries) entered into a sale and purchase Agreement with AGN
Sundry LLC to acquire 100% equity interest of Allergan Biologics Limited (“ABL”), at an estimated cash
consideration of US$120,000,000 (equivalent to RMB776,556,000). ABL (an indirect subsidiary of AbbVie
Inc., a company listed on the New York Stock Exchange) is an in-house R&D center of AbbVie Inc. for
biologics and other advanced therapeutics. It operates a manufacturing facility in Liverpool, U.K., which
is one of the most advanced research and development and clinical manufacturing facilities in the area. The
acquisition was completed in April 2021.

In order to expand into and further strengthen our capabilities in the biologics field, we acquired Absorption
Systems in November 2020 and launched our U.S. laboratory services through such acquisition. U.S.
laboratory services mainly includes DMPK/ADME and bioanalysis for both small and large molecules,
particularly in transporters, human PK prediction and translational pharmaceutics. With the completion of
the acquisition of Allergan Biologics Limited in April 2021, we expect the newly acquired facilities with
established biologics CDMO capabilities will be highly synergistic to Absorption Systems for building our
integrated CGT services platform. We are devoting significant resources to integrating our operations
following such acquisitions in order to achieve the anticipated synergies and benefits. We may also
undertake additional offshore and/or onshore acquisitions to further develop our business.

In addition, we continued to develop the discovery biologics service capabilities and accelerated the
establishment of our biologics CDMO service platform. In early 2020, we started the construction of
approximately 70,000 sq.m. of our biologics product development and manufacturing facility at our Ningbo
Hangzhou Bay service center II phase I site, and which is expected to start internal installation in June 2021
and become operational for GMP production in the second half of 2022.

The Board of the Company has proposed at the meeting of the Board held on March 26, 2021 to seek the
approval of the shareholders of the Company at the annual general meeting to be convened to approve,
among others, the repurchase and cancellation of 193,024 Restricted A Shares granted under the A Share
Incentive Scheme due to the resignation of the three grantees of such Restricted A Shares in accordance with
the provisions of the A Share Incentive Scheme, and the reduction of registered capital from
RMB794,387,462 to RMB794,194,438 and the decrease of number of issued shares of the Company from
794,387,462 shares to 794,194,438 shares, upon approval by the shareholders and completion of the
proposed repurchase and cancellation.

Subject to the required approvals by the Board and the shareholders of the Company, respectively, the
Company plans to adopt the Pharmaron 2021 A Restricted Share Incentive Scheme (the “2021 Share
Incentive Scheme”) and issue up to 774,200 A Shares of the Company under the 2021 Share Incentive
Scheme (the “Restricted A Shares”), which represents 0.0975% of the Company’s share capital as of the
date hereof. It is expected that all Restricted A Shares will be granted to eligible employees of the Company
upon the respective approvals by the Board and the shareholders of the Company, and none of the Restricted
A Shares will be reserved for future option grants. The Restricted A Shares have a vesting period of four
years, with 25% of the awards to be released on the first, second, third and fourth anniversary date of the
A Shares registration date with respect to such Restricted A Shares, respectively, and upon relevant annual
performance conditions being met.




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              DIRECTORS, SUPERVISORS AND SENIOR MANAGEMENT

Directors

The following table sets forth the key information of the Directors of the Company:

Name                                                                    Age   Position

Dr. LOU Boliang (                 ).................................    57    Chairman, chief executive officer and
                                                                              executive Director
Mr. LOU Xiaoqiang (                   ) ............................    52    Chief operating officer, president and executive
                                                                              Director
Ms. ZHENG Bei (               ) .....................................   53    Executive vice president and executive
                                                                              Director
Mr. CHEN Pingjin (             )...............................         50    Non-executive Director
Mr. HU Baifeng (           ) ..................................         39    Non-executive Director
Mr. LI Jiaqing (        ) .....................................         47    Non-executive Director
Mr. ZHOU Hongbin (               ) ............................         47    Non-executive Director
Mr. DAI Lixin (         ) .....................................         96    Independent non-executive Director
Ms. CHEN Guoqin (              ) ..............................         48    Independent non-executive Director
Mr. TSANG Kwan Hung Benson (                         ) ........         55    Independent non-executive Director
Mr. YU Jian (    ) ............................................         46    Independent non-executive Director

The biographies of the Directors are set out below.

Dr. LOU Boliang (          ), aged 57, is the chairman, chief executive officer and an executive Director of
our Company. Dr. LOU co-founded our Group together with Mr. LOU and Ms. ZHENG in July 2004. He
is primarily responsible for the overall management, strategic planning and corporate development of our
Group. He is also actively involved in formulating our business development strategy and developing
strategic relationship with our customers. He also serves as a director of most of the subsidiaries of our
Group.

Dr. LOU has the following work experience:

       Since November 2006, Dr. LOU has been a director of Pharmaron Holdings Limited, which was our
       business and asset holding vehicle prior to the restructuring in connection with our A Share Offering.

       Dr. LOU has over 25 years of experience in the life sciences and biotech industry. Prior to founding
       our Group, Dr. LOU worked at several life sciences and biotech companies such as Cytel Corporation,
       Ontogen Corporation and Advanced SynTech (formerly known as Helios Health, Inc.).

Dr. LOU obtained a master’s degree and a doctorate degree in science at the Shanghai Institute of Organic
Chemistry (                            ) in May 1986 and May 1989, respectively. From 1990 to 1994, he
conducted post-doctoral research at the University of Montreal in Canada.

Dr. LOU’s awards and recognitions include:

       President’s Special Award of the Chinese Academy of Sciences (1989);

       Beijing Overseas Returnee Entrepreneur Award (2008); and

       Bo-Da Contribution Award from the Office of Beijing Economic and Technological Development Area
       (BDA) (2010).

Dr. LOU is the brother of Mr. LOU and the brother-in-law of Ms. ZHENG.


                                                                        182
Mr. LOU Xiaoqiang (           ), aged 52, is the chief operating officer, president and an executive Director
of our Company. Mr. LOU co-founded our Group together with Dr. LOU and Ms. ZHENG in July 2004.
Mr. LOU is primarily responsible for the overall operations of the business of our Group. In particular, Mr.
LOU is responsible for the execution of our Group’s growth strategy both in China and globally. He also
serves as a director at several subsidiaries of our Group.

Mr. LOU has the following work experience:

     From March 2007 to January 2016, Mr. LOU was a director of Pharmaron Holdings Limited.

     Prior to joining our Group, he worked in sales and management roles at various electronics companies.
     For more details, please refer to the paragraphs headed “Directors, Supervisors and Senior
     Management Executive Directors” of the Prospectus.

Mr. LOU obtained a bachelor’s and a master’s degree in material science and engineering from Beijing
University of Aeronautics and Astronautics (                ) in July 1990 and March 1993, respectively.
Mr. LOU obtained a master’s degree in business administration from the China-Europe International
Business School (                   ) in September 2009.

Mr. LOU is the brother of Dr. LOU and the husband of Ms. ZHENG.

Ms. ZHENG Bei (        ), aged 53, is the executive vice president and an executive Director of our Company.
Ms. ZHENG co-founded our Group together with Dr. LOU and Mr. LOU in July 2004. Ms. ZHENG is
primarily responsible for the administration and asset management of our Group. In particular, she is
responsible for the facilities expansion of our Group.

Ms. ZHENG has the following work experience:

     From March 2007 to January 2016, Ms. ZHENG was a director of Pharmaron Holdings Limited. For
     more details of Ms. ZHENG’s previous experience, please refer to the paragraphs headed “Directors,
     Supervisors and Senior Management – Executive Directors” of the Prospectus.

Ms. ZHENG received her master’s degree in law from Peking University (                ) in July 1992.

Ms. ZHENG is the wife of Mr. LOU and the sister-in-law of Dr. LOU.

Mr. CHEN Pingjin (         ), aged 50, is our non-executive Director. Mr. CHEN is primarily responsible
for providing guidance on corporate strategy and governance to our Group. Mr. CHEN joined our Group
on October 13, 2017.

Mr. CHEN has the following work experience:

     Since April 2016, Mr. CHEN has served as a deputy general manager of Gold Stone Investment Co.,
     Ltd. (                  ) (“Gold Stone Investment”), a subsidiary of CITIC Securities Co., Ltd. (
                         ), a company listed on the Shanghai Stock Exchange (stock code: 600030) where
     he has successively served various roles from December 2006 to March 2016.

Mr. CHEN obtained his bachelor’s degree in electrical engineering from East China Jiaotong University (
           ) in July 1992. He obtained his master’s degree in information economics from Beijing Jiaotong
University (               ) (formerly known as Northern Jiaotong University (                 )) in April
1998.



                                                    183
Mr. HU Baifeng (        ), aged 39, is our non-executive Director. Mr. HU is primarily responsible for
providing guidance on corporate strategy and governance to our Group. Mr. HU joined our Group on
October 27, 2016 and was our Supervisor from October 2016 to October 2017.

Mr. HU has the following work experience:

     Since March 2018, he has served as a board director of Ampleon Cooperatief UA, a company
     primarily engaged in the financial holdings business in the Netherlands.

     Since February 2017, Mr. HU has served as a director of Gold Stone Investment. From May 2014 to
     January 2017, Mr. HU served as a director at CITIC M&A Fund.

     From 2006 to 2013, he worked at the investment department of several companies.

Mr. HU obtained his bachelor’s degree in economics from Hunan University (          ) in June 2003. He
obtained his master’s degree in economics from the University of Ottawa in Canada in October 2005.

Mr. LI Jiaqing (        ), aged 47, is our non-executive Director. Mr. LI is primarily responsible for
providing guidance on corporate strategy and governance to our Group. Mr. LI joined our Group on March
12, 2007.

Mr. LI has the following work experience:

     From March 2007 to January 2016, Mr. LI was a director of Pharmaron Holdings Limited.

     Since 2007, he has served as a managing director of Legend Capital.

     From December 2011 to February 2018, he served as a director of Wuxi Lead Intelligent Equipment
     Co., Ltd. (                           ), a company listed on the Shenzhen Stock Exchange (stock
     code: 300450).

     From March 2011 to February 2014, he served as a supervisor of Shanghai Amarsoft Information
     Technology Co., Ltd. (                            ), a company listed on the Shenzhen Stock
     Exchange (stock code: 300380).

     From September 2010 to April 2018, Mr. LI served as a director of Yunnan Hongxiang Yixintang
     Pharma Co., Ltd. (                 (    )             ), a company listed on the Shenzhen Stock
     Exchange (stock code: 002727).

     From 2001 to 2007, he successively served as vice president, senior vice president, and executive
     director of Legend Capital.

Mr. LI obtained his dual bachelor’s degree in mechanical engineering and economic management and a
Master’s degree in management from Tsinghua University (                ) in July 1996 and July 1999,
respectively. He obtained his master’s degree in business administration from the Engineering School of
Paris in France in June 2001.




                                                  184
Mr. ZHOU Hongbin (          ), aged 47, is our non-executive Director. Mr. ZHOU is primarily responsible
for providing guidance on corporate strategy and governance to our Group. Mr. ZHOU joined our Group
on October 27, 2016.

Mr. ZHOU has the following work experience:

     Since September 2015, he has served as a director of Milkyway Chemical Supply Chain Service Co.,
     Ltd. (                                      ), a company listed on the Shanghai Stock Exchange
     (stock code: 603713).

     Since June 2015, he has served as a supervisor of Guangzhou Kingmed Diagnostics Group Co., Ltd.
     (                                    ), a company listed on the Shanghai Stock Exchange (stock
     code: 603882).

     Since April 2015, he has served as a managing director of Legend Capital.

     From 2005 to 2015, he successively served as investment manager, investment vice president,
     investment director and executive director of Legend Capital.

Mr. ZHOU obtained his bachelor’s degree in urban construction and master’s degree in engineering from
Wuhan University (        ) in July 1994 and June 1997, respectively. He obtained his doctorate degree
in management from Fudan University (           ) in July 2000.

Mr. DAI Lixin (       ), aged 96, was appointed as an independent non-executive Director on October 27,
2016. Mr. DAI is primarily responsible for supervising and providing independent advice to the Board.

Mr. DAI has the following work experience:

     In 1953, Mr. DAI was assigned by the Chinese Academy of Sciences (                   ) to work in the
     Shanghai Institute of Organic Chemistry (                    ) (the “SIOC”), where he has continued
     his study of organic chemistry till now. He served successively in SIOC as an assistant researcher,
     associate researcher and since 1986 as a research professor.

     From 1950 to 1953, he served in administration positions in the Shanghai Iron and Steel Company (
               ) and the Shanghai Bureau of Minerals and Metallurgy (                ).

     In 1948, he joined the Shanghai Third Iron and Steel Factory (                               ) as an
     engineer in the analytical laboratory.

     From 1947 to 1948, he worked as a teacher in Zhong-Hua Vocational School (                    ).

Mr. DAI obtained his bachelor’s degree from the Chemistry Department of Zhejiang University (           )
in 1947. In 1993, Mr. DAI was elected as an academician of the Chinese Academy of Sciences. He has
published more than 200 academic papers and 11 books and has authorized 13 patents in China. He has
supervised 38 students to obtain doctorate degrees and 3 students to obtain master’s degrees. He is a
member of the Chinese Chemical Society (                  ) and also a member of Shanghai Society of
Chemistry and Chemical Industry (                      ), and currently an honorary chairman of the latter
society. Mr. DAI has won twice the National Natural Science 2nd Class Awards (                           )
in 2002 and in 2013, the Ho Leung Ho Lee Foundation Science and Technology Progress Award (
                         ) in 2002 and the Chiral Chemistry Lifetime Achievement Award of Chinese
Chemical Society (                             ) in 2014, and the Lifetime Achievement Award by the
Chinese Chemical Society in 2018.


                                                   185
Ms. CHEN Guoqin (        ), aged 48, was appointed as an independent non-executive Director on October
27, 2016. Ms. CHEN is primarily responsible for supervising and providing independent advice to the
Board.

Ms. CHEN has the following work experience:

     Since February 2001, she has been a lawyer at S&P Law Firm (                             ), a law firm
     based in Beijing, where she currently serves as a director and senior partner.

Ms. CHEN obtained her bachelor’s degree in economics from Xiamen University (           ) in July 1995.
Ms. CHEN obtained her master’s degree in law from the Beijing University of International Business and
Economics (                       ) in June 2006.

Mr. TSANG Kwan Hung Benson (               ), age 55, was appointed as an independent non-executive
Director on August 15, 2019 (effective from the Listing Date). Mr. TSANG is primarily responsible for
supervising and providing independent advice to the Board.

Mr. TSANG has the following work experience:

     Since March 2019, he has served as the director of Hongsen Investment Management Limited, the
     general partner of Hongsen Investment Fund L.P. which started operation since January 2020.

     Since July 2018, he has served as an independent director and chairman of the audit committee of
     Athenex Inc., a company listed in the United States (NASDAQ: ATNX).

     From July 2017 to August 2020, he has served as a director of the board of Puritek Canada Inc., the
     Canadian investment arm of Puritek China Company.

     From July 2014 to August 2020, he has served as a director of the board of Hydraservices Inc., a waste
     management and odour control solutions company based in Canada.

     From October 2017 to December 2018, he served as an executive-in-residence adviser at
     ShangPharma Innovation Inc., an early stage pharmaceutical company based in the United States.

     From March 2010 to June 2015, he served as the chief financial officer of ATA Inc., a large scale
     computer-based testing service provider listed in the United States (NASDAQ: ATAI).

     From November 2010 to March 2013, he served as an independent director at ShangPharma Corp., a
     pharmaceutical R&D contract service organization company previously listed in the United States
     (NYSE: SHP), which was privatized in September 2013.

     From July 2006 to February 2009, he served as the chief financial officer of Wuxi Pharma Tech
     Cayman Inc., a pharmaceutical R&D contract service organization company previously listed in the
     United States (NYSE: WX), which was privatized in December 2015.

     From 1988 to 2006, Mr. TSANG served in finance and audit roles at various companies.

Mr. TSANG obtained his Chartered Accountant certificate in Canada and Hong Kong in 1991 and 1993,
respectively. He is a member (non-practicing) of the Hong Kong Institute of Certified Public Accountants.
He obtained his bachelor’s degree in commerce and his master’s degree in business administration at
McMaster University in Canada in June 1987 and May 1988, respectively.



                                                   186
Mr. YU Jian (     ), aged 46, was appointed as an independent non-executive Director on July 23, 2020.
Mr. YU is primarily responsible for supervising and providing independent advice to the board.

Mr. YU has extensive experience in finance and accounting.

Mr. YU has the following work experience:

       Since September 2015, he has served as independent director of Milkyway Chemical Supply Chain
       Services Co., Ltd. (                                    ).

       Since May 2015, he has served as independent director of Pengxin International Mining Co., Ltd. (
                               ).

       Since October 2008, he has worked in the Teaching and Research Department of Shanghai National
       Accounting Institute (                 ) as an associate professor, and engaged in teaching and
       research in financial management.

       From January to September 2008, he served as the financial director of Infoservice Information
       Technology Co., Ltd. (                            ).

       From January 2006 to January 2008, he served as the financial director of Shanghai Chengtou Land
       Group Co., Ltd. (                          ).

       From December 2004 to January 2006, he served as the financial director of Shanghai Transportation
       Investment Group Co., Ltd. (                           ).

       From August 2002 to December 2004, he served as the financial director of Shanghai Pulan
       Investment Management Co., Ltd. (                     ).

       From March 1999 to February 2002, he served successively as the financial supervisor of the Planning
       and Finance Department, deputy head of the audit and supervision department, and deputy head of the
       project investment department in the headquarters of Shanghai Chengtou Group Corporation (
              ).

Mr. YU is a CPA, and obtained his bachelor’s degree in economics from Zhejiang Institute of Finance (
           ) in July 1996. Mr. YU obtained his master’s degree in management from Shanghai University
of Finance and Economics (               ) in January 1999. He obtained his PhD in management from
Shanghai University of Finance and Economics (                 ) in July 2005.

Supervisor

Name                                                               Age   Position

Dr. YANG Kexin (             ) .................................   57    Chairman of the Supervisory Committee
Ms. FENG Shu (         ) .......................................   35    Supervisor
Ms. ZHANG Lan (           ) ....................................   38    Employee representative Supervisor

The biographies of the Supervisors are set out below.

Dr. YANG Kexin (          ), aged 57, was appointed as the chairman of the Supervisory Committee on
October 27, 2016 and is primarily responsible for the overall operation of the Supervisory Committee and
supervision of the performance of the Directors and senior management members. Dr. YANG joined our
Group on July 1, 2004 and is currently our vice president of chemical technology.

Dr. YANG obtained his master’s degree in organic chemistry at Lanzhou University (          ) in June
1986. He obtained his doctorate degree in organic chemistry at the University of Calgary in Canada in
November 1992.


                                                                   187
Ms. FENG Shu (        ), aged 35, was appointed as a Supervisor on December 11, 2020. Ms. FENG is
primarily responsible for the supervision of the performance of the Directors and senior management
members.

Mr. FENG has the following work experience:

       From February 2016 to May 2017, she served as Vice President and Senior Vice President of CITIC
       M&A Fund Management Co., Ltd.* (                             ) (“CITIC M&A Fund”), which is a
       substantial shareholder of the Company.

       Since May 2017, she has worked at Goldstone Investment Co., Ltd.* (              ) (“Goldstone
       Investment”), the sole shareholder of CITIC M&A Fund, and currently serves as the Director at
       Goldstone Investment;

       Since August 2019, she has served as the Director, the Head of Strategy and Business Development,
       the Director of Real Estate of CLSA Capital Partners (HK) Limited and a Member of the Investment
       Committee of CLSA Capital Partners (HK) Limited.

Ms. FENG obtained her bachelor’s degree from Zhejiang University (                            ) and a master’s degree from
Baylor University in the U.S.

Ms. ZHANG Lan (         ), aged 38, was appointed as the employee representative Supervisor on October
27, 2016 and is primarily responsible for the supervision of the performance of the Directors and senior
management members. Ms. ZHANG joined our Group on April 5, 2006 and currently serves as our associate
director.

Ms. ZHANG obtained her bachelor’s degree in English at Tangshan Teacher’s College (                                   ) in
Hebei, China in June 2005.

Senior Management

Name                                                                  Age   Position

Dr. LOU Boliang (               ).................................    57    Chairman, chief executive officer and an
                                                                            executive director
Mr. LOU Xiaoqiang (                 ) ............................    52    Chief operating officer, president and an
                                                                            executive Director
Ms. ZHENG Bei (             ) .....................................   53    Executive vice president and an executive
                                                                            Director
Dr. YANG Hua (     )........................................          58    Chief scientific officer
Mr. LI Shing Chung Gilbert (              ) ................          42    Chief financial officer

The biographies of the Senior Management are set out below.

Dr. LOU Boliang (           ), aged 57, is the chairman, chief executive officer and an executive Director of
our Company. Dr. LOU co-founded our Group together with Mr. LOU and Ms. ZHENG in July 2004. He
is primarily responsible for the overall management, strategic planning and corporate development of our
Group. He is also actively involved in formulating our business development strategy and developing
strategic relationship with our customers. He also serves as a director of most of the subsidiaries of our
Group. See “– Directors” for more details.

Mr. LOU Xiaoqiang (           ), aged 52, is the chief operating officer, president and an executive Director
of our Company. Mr. LOU co-founded our Group together with Dr. LOU and Ms. ZHENG in July 2004.
Mr. LOU is primarily responsible for the overall operations of the business of our Group. In particular, Mr.
LOU is responsible for the execution of our Group’ growth strategy both in China and globally. He also
serves as a director at several subsidiaries of our Group. See “– Directors” for more details.


                                                                      188
Ms. ZHENG Bei (        ), aged 53, is the executive vice president and an executive Director of our Company.
Ms. ZHENG co-founded our Group together with Dr. LOU and Mr. LOU in July 2004. Ms. ZHENG is
primarily responsible for the administration and asset management of our Group. In particular, she is
responsible for the facilities expansion of our Group. See “– Directors” for more details.

Dr. YANG Hua (         ), aged 58, is our chief scientific officer. He joined our Group in July 2007 as our chief
scientific officer and is primarily responsible for the overall research and scientific development strategy
for the integrated services platform of our Group. Since March 2017, he has also served as a director of one
of our subsidiaries.

Dr YANG has the following work experience:

     Prior to joining our Group, he successively served in various roles, including assistant director, at
     AstraZeneca R&D Montreal.

     Since joining our Group in 2007, Dr. YANG has extensively engaged in the service R&D platform
     building, encompassing discovery, preclinical and clinical development and their integration.

Dr. YANG obtained his doctorate degree at The Victoria University of Manchester (currently known as the
University of Manchester) in England in November 1990. He also conducted his post-doctoral research at
the University of Montreal in Canada. Dr. YANG is a co-author and co-inventor for 46 peer-reviewed
scientific publications and patent applications.

Mr. LI Shing Chung Gilbert (            ), aged 42, is our chief financial officer and secretary of our Board.
He joined our Group in January 2008 as our financial controller and was appointed as our chief financial
officer in January 2015. He was appointed as the secretary of the Board in October 2016 and is primarily
responsible for the overall financial function of our Group. In particular, he is responsible for the financing
and M&A activities of our Group. Mr. LI also serves as a supervisor or director at several subsidiaries of
our Group.

Mr. LI has the following work experience:

     Prior to joining our Group, Mr. LI had served at various roles in accounting and financial areas. From
     2000 to 2003, he served as assistant manager of KPMG, a multinational financial audit, tax and
     advisory firm.

Mr. LI obtained his bachelor’s degree in business administration from the Hong Kong University of Science
and Technology in November 2000. Mr. LI obtained his master’s degree in business administration from the
China Europe International Business School (                       ) in July 2012. Mr. LI is a member of the
Hong Kong Institute of Certified Public Accountants and the American Institute of Certified Public
Accountants and a Chartered Financial Analyst.




                                                      189
                                   MARKET PRICE INFORMATION

The H shares have been listed on the Hong Kong Stock Exchange (Code: 3759) since the Issuer’s initial
public offering on November 28, 2019. Prior to that time, there was no public market for the Issuer’s H
Shares. The Issuer’s publicly traded domestic shares, or A Shares, are listed on the Shenzhen Stock
Exchange (Code: 300759. SZ) since January 28, 2019.

The table below sets forth, for the periods indicated, the high and low closing prices per H share, as reported
on the Hong Kong Stock Exchange, and per A Share, as reported on the Shenzhen Stock Exchange:

                                                                                 Closing Share Price
                                                                     H Share                           A Shares
Year                                                          High              Low             High              Low
                                                                      (HK$)                            (RMB)
2019
First quarter ended March 31, 2019 ..............                     –               –          44.90            11.03
Second quarter ended June 30, 2019 .............                      –               –          44.25            32.13
Third quarter ended September 30, 2019 ......                         –               –          47.16            33.15
Fourth quarter ended December 31, 2019(1) ..                      44.85            40.45           57.22            46.29
2020
First quarter ended March 31, 2020 ..............               57.10              40.70           68.60            47.70
Second quarter ended June 30, 2020 .............                80.00              51.20           98.40            58.68
Third quarter ended September 30, 2020 ......                  105.60              79.50          116.16            92.11
Fourth quarter ended December 31, 2020 .....                   131.40              94.10          120.40            93.60
2021
First quarter ended March 31, 2021 ..............              178.00            111.30           169.66           104.40
Second quarter ended May 31, 2021 .............                191.00            141.80           189.63           146.37

Note: The H Shares closing share price information is only available since November 28, 2019.




                                                            190
                                                          EXCHANGE RATE

PRC

The PBOC sets and publishes on a daily basis a base exchange rate with reference primarily to the supply
and demand of Renminbi against a basket of currencies in the market during the prior day. The PBOC also
takes into account other factors, such as the general conditions existing in the international foreign
exchange markets. On July 21, 2005, the PRC government introduced a managed floating exchange rate
system to allow the value of the Renminbi to fluctuate within a regulated band based on market supply and
demand and by reference to a basket of currencies. On the same day, the value of the Renminbi appreciated
by 2.0 per cent. against the U.S. dollar. The PRC government has since made and in the future may make
further adjustments to the exchange rate system. On May 18, 2007, the PBOC enlarged, effective on May
21, 2007, the floating band for the trading prices in the inter-bank spot exchange market of Renminbi
against the U.S. dollar from 0.3 per cent. to 0.5 per cent. around the central parity rate. This allows the
Renminbi to fluctuate against the U.S. dollar by up to 0.5 per cent. above or below the central parity rate
published by the PBOC. The floating band was further widened to 1.0 per cent. on April 16, 2012. These
changes in currency policy resulted in the Renminbi appreciating against the U.S. dollar by approximately
26.9 per cent. from July 21, 2005 to December 31, 2013. The PBOC authorized the China Foreign Exchange
Trading Centre, effective since January 4, 2006, to announce the central parity exchange rate of certain
foreign currencies against the Renminbi on each business day. This rate is set as the central parity for the
trading against the Renminbi in the inter-bank foreign exchange spot market and the over-the-counter
exchange rate for the following business day. On March 14, 2014, the PBOC further widened the floating
band against the U.S. dollar to 2.0 per cent. On August 11, 2015, the PBOC announced to improve the
central parity quotations of Renminbi against the U.S. dollar by authorizing market-makers to provide
central parity quotations to the China Foreign Exchange Trading Centre daily before the opening of the
interbank foreign exchange market with reference to the interbank foreign exchange market closing rate of
the previous day, the supply and demand for foreign exchange as well as changes in major international
currency exchange rates. Following the announcement by the PBOC on August 11, 2015, Renminbi
depreciated significantly against the U.S. dollar. In January and February 2016, Renminbi experienced
further fluctuation in value against the U.S. dollar. The PRC government may adopt further reforms of its
exchange rate system, including making the Renminbi freely convertible in the future.

The following table sets forth the noon buying rates for U.S. dollars in New York City for cable transfers
payable in Renminbi as certified by the Federal Reserve Bank of New York for customs purposes for and
as of the periods indicated as set forth in the H.10 statistical release of the Federal Reserve Board.

                                                                                        Noon Buying Rate
Period                                                                Low          Average(1)           High            Period End
                                                                                     (Renminbi per US$1.00)
2017 ..............................................................     6.4773         6.7350             6.9575             6.5063
2018 ..............................................................     6.2649         6.6292             6.9737             6.8755
2019 ..............................................................     6.6822         6.9014             7.1786             6.9618
2020 ..............................................................     6.5208         6.8878             7.1681             6.5250
2021
  January ......................................................        6.4282         6.4672             6.4822             6.4282
  February ....................................................         6.4344         6.4601             6.4869             6.4730
  March ........................................................        6.4648         6.5109             6.5716             6.5518
  April ..........................................................      6.4710         6.5186             6.5649             6.4749
  May (as of May 28, 2021).........................                     6.3674         6.4321             6.4749             6.3674

Note:

(1)      Annual averages are calculated by averaging the rates on the last business day of each month during the relevant year. Period
         averages are calculated by averaging the daily rates during the relevant period.



                                                                      191
Hong Kong

The HK dollar is freely convertible into the U.S. dollar. Since 1983, the HK dollar has been linked to the
U.S. dollar at the rate of HK$7.80 to US$1.00. The Basic Law of the Hong Kong Special Administrative
Region of the People’s Republic of China (the “Basic Law”), which came into effect on July 1, 1997,
provides that no foreign exchange control policies shall be applied in Hong Kong.

The market exchange rate of the HK dollar against the U.S. dollar continues to be determined by the forces
of supply and demand in the foreign exchange market. However, against the background of the fixed rate
system which applies to the issuance and withdrawal of Hong Kong currency in circulation, the market
exchange rate has not deviated significantly from the level of HK$7.80 to US$1.00. The Hong Kong
government has indicated its intention to maintain the link at that rate. Under the Basic Law, the HK dollar
will continue to circulate and remain freely convertible. The Hong Kong government has also stated that
it has no intention of imposing exchange controls in Hong Kong and that the HK dollar will remain freely
convertible into other currencies, including the U.S. dollar. However, the Company cannot assure you that
the Hong Kong government will maintain the link at HK$7.80 to US$1.00, or at all.

The following table sets forth, for the periods indicated, certain information concerning the exchange rates
between Hong Kong dollars and U.S. dollars. The exchange rates reflect the noon buying rates as set forth
in the H.10 statistical release of the Federal Reserve Board:

                                                                                        Noon Buying Rate
Period                                                                Low          Average(1)           High            Period End
                                                                                    (Hong Kong per US$1.00)
2017 ..............................................................     7.7540         7.7950             7.8267             7.8128
2018 ..............................................................     7.8043         7.8376             7.8499             7.8305
2019 ..............................................................     7.7850         7.8335             7.8499             7.7894
2020 ..............................................................     7.7498         7.7562             7.7951             7.7534
2021
  January ......................................................        7.7517         7.7533             7.7555             7.7531
  February ....................................................         7.7515         7.7529             7.7567             7.7567
  March ........................................................        7.7562         7.7651             7.7746             7.7746
  April ..........................................................      7.7596         7.7691             7.7849             7.7664
  May (as of May 28, 2021).........................                     7.7608         7.7654             7.7697             7.7610

Note:

(1)      Annual averages are calculated by averaging the rates on the last business day of each month during the relevant year. Period
         averages are calculated by averaging the daily rates during the relevant period.




                                                                      192
                                              DIVIDENDS

Pursuant to the Articles of Association, the Board may declare dividends in the future after taking into
account the Company’s results of operations, financial condition, cash requirements and availability, and
other factors as it may deem relevant at such time. Although the calculation of the Company’s net profit and
undistributed profit is in accordance with PRC GAAP, which may differ from the numbers calculated under
IFRS, the Company does not expect such difference to be material and to have any substantive impact on
its dividend policy. Any declaration and payment as well as the amount of dividends will be subject to the
Company’s Articles of Association, applicable PRC laws, and approval by the Company’s Shareholders.
Under the Articles of Association, when the Company makes a profit in the current year and the
accumulated undistributed profit is positive, the Company shall give priority to the distribution of cash
dividends provided that there is no material capital expenditure or investment in the next 12 months. The
total amount of the cash dividends distributed shall be at least 20% of the total dividends in the same
distribution.

While the Company generally expects to declare dividends once per year, in the event that the net profit for
the first six months of a given year exceeds the net profit for the preceding year, the Directors have the
discretion to declare and pay interim dividends which would be subject to the approval by the Shareholders
in a general meeting. No dividend shall be declared or payable except out of the Company’s profits and
reserves lawfully available for distribution. The Company’s future declarations of dividends may or may not
reflect historical declarations of dividends and will be at the absolute discretion of the Directors.

Future dividend payments will also depend upon the availability of dividends received from the subsidiaries
of the Company in China. PRC laws require that dividends be paid only out of distributable profits
calculated according to PRC accounting principles, which differ in many aspects from generally accepted
accounting principles in other jurisdictions, including IFRS. In addition, as stipulated by the Articles of
Association, distributable profits are recognized as net profit determined under PRC GAAP or IFRS,
whichever is lower, less any recovery of accumulated losses and appropriations to statutory and other
reserves that the Company is required to make. As a result, the Company and PRC operating subsidiaries
of the Company may not be able to pay a dividend in a given year if the Company and PRC operating
subsidiaries do not have distributable profits as determined under PRC GAAP even if they have profits as
determined under IFRS. Distributions from the subsidiaries of the Company may also be restricted if they
incur debt or losses, or in accordance with any restrictive covenants in bank credit facilities or other
agreements that the Company or its subsidiaries may enter into in the future.

The Company did not pay or declare any dividend to its shareholders for the year ended December 31, 2018.

On May 15, 2019, the Company’s Shareholders approved the 2018 Profit Distribution Plan at an annual
general meeting, pursuant to which a dividend of RMB1.10 (inclusive of tax) for every 10 shares of the
Company in an aggregate amount of RMB72,192,000 was subsequently paid in July 2019 to shareholders
of the Company on the record date.

On May 28, 2020, the Company’s shareholders approved the 2019 Profit Distribution Plan at annual general
meeting, pursuant to which a final dividend of RMB0.15 (inclusive of tax) per share in respect of the year
ended December 31, 2019 was declared to both holders of A shares and H shares and aggregate dividend
amounted to approximately RMB119,158,000 (inclusive of tax). Except for the dividend declared to the
holders of restricted A shares that would be paid no earlier than the unlocking date, the rest of the dividend
was paid in July 2020.

The Company proposed to declare a final dividend of RMB3.00 (inclusive of tax) per 10 shares or an
aggregate of approximately RMB238.3 million for the year ended December 31, 2020. The proposed final
dividend for the year ended December 31, 2020 was approved by the Company’s shareholders at the annual
general meeting dated May 28, 2021.


                                                     193
                SUBSTANTIAL SHAREHOLDERS’ AND DIRECTORS’ AND
                         CHIEF EXECUTIVES’ INTERESTS

Directors’ and Chief Executives’ Interests in Shares

As of December 31, 2020, the interests and short positions of the Directors, the Supervisors and the chief
executives of the Company in the Shares, underlying shares and debentures of the Company or any of its
associated corporations (within the meaning of Part XV of the SFO) as notified to the Company and the
Stock Exchange pursuant to Divisions 7 and 8 of Part XV of the SFO (including interests and short positions
which he/she is keen to taken or deemed to have under such provisions of the SFO), or as recorded in the
registered maintained by the Company under section 352 of the SFO, or as notified to the Company and the
Stock Exchange pursuant to the Model Code were as follows:

Long Position in Shares

                                                                                                                Approximate
                                                                                                              percentage of the
                                                                                      Number and class        Company’s issued
Name of Director               Name of Interest                                       of share interested       share capital

Dr. LOU Boliang.......         Interests held jointly with another person;                 187,423,105                  23.59%
                                 interests of controlled corporation
Mr. LOU Xiaoqiang ..           Beneficial owner; interests held jointly                    187,423,105                  23.59%
                                 with another person; interests of
                                 controlled corporation; interests of
                                 spouse
Ms. ZHENG Bei .......          Interests held jointly with another person;                 187,423,105                  23.59%
                                 interests of controlled corporation;
                                 interests of spouse

Notes:

1.       Dr. LOU Boliang, Mr. LOU Xiaoqiang and Ms. ZHENG Bei have entered into a voting rights agreement on October 19, 2018
         (which formalizes their pre-existing voting arrangement), pursuant to which they have agreed to reach consensus on any
         proposal presented to the Board and the general meeting of the shareholders of the Company for voting (the “Voting
         Agreement”). Pursuant to the Voting Agreement, Dr. LOU Boliang, Mr. LOU Xiaoqiang and Ms. ZHENG Bei are concert parties
         and they are deemed to be interested in each other’s interests in our Company under the SFO.

2.       Mr. LOU Xiaoqiang and Ms. ZHENG Bei are spouses.


Save as disclosed above, as of December 31, 2020, to the knowledge of the Board, none of the Directors,
the Supervisors or chief executives of the Company had any interests or short positions in the shares,
underlying shares and debentures of the Company or any of its associated corporations (within the meaning
of Part XV of the SFO) which were required to be (i) notified to the Company and the Stock Exchange
pursuant to Divisions 7 and 8 of Part XV of the SFO (including interests and short positions which the
Directors, the Supervisors and chief executives of the Company were taken or deemed to have under such
provisions of the SFO); (ii) recorded in the register kept by the Company pursuant to Section 352 of the
SFO; or (iii) notified to the Company and the Stock Exchange pursuant to the Model Code.




                                                               194
Substantial Shareholders’ Interests in Securities and Short Position in the Shares and Underlying
Shares of the Company

As of December 31, 2020, according to the register kept by the Company pursuant to Section 336 of the
SFO and so far is known to, or can be ascertained after reasonable enquiry by the Directors, the following
person/entity had an interest or short position in the Shares and underlying Shares which would fall to be
disclosed to the Company and the Stock Exchange pursuant to Divisions 2 and 3 of Part XV of the SFO,
or be directly and indirectly interested in 5% or more of the nominal value of any class of share capital
carrying rights to vote on all circumstances at general meetings of the Company:

Interests in the Shares of the Company

                                                                                                             Approximate
                                                                                                            percentage in
                                                                                                            the respective    Percentage in
                                        Class of                                         Number of          class of share    total number
Name of Shareholder                     Shares       Nature of Interest                   Shares(1)             capital         of Shares

Pharmaron Holdings                      Domestic     Beneficial owner                  97,600,003 (L)                14.78%        12.29%
  Limited(2) ........................
CITIC Securities Co. Ltd.               Domestic     Interest of controlled          185,637,121 (L)                 28.11%        23.37%
  (                                )                   Corporation
  (“CITIC Securities”)(3) ..
Beijing Junlian Tongdao                 Domestic     Interest of controlled            78,478,871 (L)                11.88%         9.88%
  Investment Management                                Corporation
  Partnership (Limited
  Partnership) (
                              (
         )) (“Junlian
  Tongdao”)(4) ...................
JPMorgan Chase & Co(5) ....             H Shares     Interest of controlled            17,094,630 (L)                12.75%         2.15%
                                                       Corporation;                     1,226,000 (S)                 0.91%         0.15%
                                                       investment                       8,763,989 (P)                 6.53%         1.10%
                                                       manager, person
                                                       having a security
                                                       interest in shares,
                                                       approved lending
                                                       agent
The Capital Group                 H Shares           Interest of controlled            16,060,700 (L)                11.98%         2.02%
  Companies, Inc.(6) ..........                        Corporation
BlackRock, Inc.(7) .............. H Shares           Interest of controlled             7,931,600 (L)                5.92%          1.00%
                                                       Corporation
FMR LLC(8) ....................... H Shares          Interest of controlled             9,506,236 (L)                7.09%          1.20%
                                                       Corporation
China Structural Reform                 H Shares     Beneficial owner                   7,931,600 (L)                5.92%          1.00%
  Fund Corporation
  Limited (

    ) (“China Structural
  Reform Fund”)(9) ..........
FIDELITY INVESTMENT H Shares                         Beneficial owner                   6,825,267 (L)                5.09%          0.86%
  TRUST ...........................

Notes:

1.       The letter “L”, “S” and “P” stand for long position, short position and lending pool, respectively.

2.       Pharmaron Holdings Limited is held as to 67.03% by Dr. LOU Boliang.



                                                                     195
3.   Shenzhen Xinzhong Kangcheng Investment Partnership (Limited Liability Partnership) (                              (
       )) (“Shenzhen Xinzhong Kangcheng”) directly held 157,142,855 A Shares. To the best knowledge of our Company, the
     general partner of Shenzhen Xinzhong Kangcheng is CITIC Buyout Fund Management Company Limited (
               ) (“CITIC Fund”). Shenzhen Xinzhong Kangcheng is held as to 50.16% by CITIC Buyout Investment Fund (Shenzhen)
     (Limited Partnership) (                    (    )       (          )) (“CITIC Fund Shenzhen”) as a limited partner, the
     general partner of which is CITIC Fund. CITIC Fund is wholly-owned by Gold Stone Investment Co., Ltd (
       ), which is in turn wholly-owned by CITIC Securities, a company listed on the Hong Kong Stock Exchange (stock code:
     6030). In addition, CITIC Securities is also considered as having control over CITIC Fund Shenzhen according to the
     investment contract.

4.   Tianjin Junlian Wenda Equity Investment Partnership (Limited Partnership) (                                                         (         ))
     (“Junlian Wenda”) directly held 72,332,628 A Shares. To the best knowledge of our Company, the general partner of Junlian
     Wenda is Junlian Tongdao, the general partner of which is Lasa Junqi Enterprise Management Co., Ltd. (
              ) (“Lasa Junqi”). Junlian Tongdao is held as to 76.41% by Beijing Junqi Tongdao Investment Consultancy Partnership
     (Limited Partnership) (                                (              )) (“Junqi Tongdao”) as a limited partner, the general partner of
     which is Lasa Junqi. Junqi Tongdao is held as to 74.83% by Lasa Bodao Investment Management Partnership (Limited
     Partnership) (                                (          )) (“Lasa Bodao”) as a limited partner. Lasa Junqi is wholly-owned by
     Legend Capital, which is held as to 80% by Beijing Juncheng Hezhong Investment Management Partnership (Limited
     Partnership) (                                    (            )) (“Juncheng Hezhong”). The general partner of Juncheng Hezhong is
     Beijing Junqi Jiarui Enterprise Management Co., Ltd. (                                                ) (“Junqi Jiarui”), which is held as to
     40%, 40% and 20% by Mr. WANG Nengguang (                       ), Mr. CHEN Hao (             ) and Mr. ZHU Linan (              ), respectively.
     Juncheng Hezhong is owned as to 58.12% and 41.87% by Tianjin Huizhi Yihao Enterprise Management Consultancy
     Partnership (Limited Partnership) (                                                   (         )) (“Huizhi Yihao”) and Tianjin Junlian
     Jieyou Enterprise Management Consultancy Partnership (Limited Partnership) (                                                           (
        )) (“Junlian Jieyou”) as limited partners, respectively. Huizhi Yihao is owned as to 48.85% by Mr. ZHU Linan (                         ) as
     limited partner. Additionally, Junlian Wenda is held as to 39.48% by Beijing Junlian Xinhai Equity Investment Partnership
     (Limited Partnership) (                                      (              )) (“Junlian Xinhai”) as a limited partner, the general partner
     of which is Junlian Tongdao. Therefore, Junlian Xinhai is deemed to be interested in the same number of A Shares in which
     Junlian Wenda is interested under the SFO. In addition, Junlian Maolin directly held 6,146,243 A Shares. To the best knowledge
     of our Company, the general partner of Junlian Maolin is Junlian Tongdao. As such, Junlian Tongdao, Lasa Junqi, Junqi
     Tongdao, Lasa Bodao, Legend Capital, Juncheng Hezhong, Junqi Jiarui, Huizhi Yihao, Junlian Jieyou, Mr. WANG Nengguang
     (         ), Mr. CHEN Hao (          ) and Mr. ZHU Linan (              ) are deemed to be interested in our A Shares held by Junlian
     Wenda and Junlian Maolin under the SFO.

5.   JPMorgan Chase & Co. has a total interest of 17,094,630 (long position), 1,226,000 (short position) and 9,763,9890 (lending
     pool) Shares in our Company by virtue of its relationship with a number of corporation. According to the disclosure of interest
     notice filed by JPMorgan Chase & Co. with a relevant event date of December 23, 2020, the following interest in H shares were
     held by JPMorgan Chase & Co.

                                                                                                 %            Direct interest        Number of
     Name of controlled corporation                     Name of controlling person             control            (Y/N)               shares
     China International Fund                           JPMORGAN ASSET                             49.00                     Y         908,400 (L)
       Management Co., Ltd..................               MANAGEMENT (UK)
                                                           LIMITED
     JPMorgan Asset Management                          JPMorgan Asset Management                 100.00                     Y         206,500 (L)
        (Taiwan) Limited ........................          (Asia) Inc.
     J.P. Morgan Securities LLC .............           J.P. Morgan Broker-Dealer                 100.00                     Y         396,300 (L)
                                                           Holdings Inc.
     JPMORGAN CHASE BANK, N.A.                          JPMorgan Chase Bank, National             100.00                     Y       8,763,989 (L)
        – LONDON BRANCH ................                  Association
     JPMORGAN ASSET                                     JPMORGAN ASSET                            100.00                     Y          25,700 (L)
        MANAGEMENT (UK)                                    MANAGEMENT
        LIMITED ....................................       INTERNATIONAL LIMITED
     J.P. Morgan Investment                             JPMorgan Asset Management                 100.00                     Y         321,100 (L)
        Management Inc..........................           Holdings Inc.
     JPMorgan Chase Bank, National                      JPMorgan Chase & Co.                      100.00                     Y         276,600 (L)
        Association .................................
     JPMorgan Asset Management (Asia                    JPMorgan Asset Management                  99.99                     Y       3,539,600 (L)
        Pacific) Limited ..........................        (Asia) Inc.
     J.P. MORGAN SECURITIES PLC ..                      J.P. MORGAN CAPITAL                       100.00                     Y       2,656,441 (L)
                                                           HOLDINGS LIMITED                                                          1,226,000 (S)
     JPMORGAN ASSET                                     JPMORGAN ASSET                            100.00                     N         908,400 (L)
       MANAGEMENT (UK)                                     MANAGEMENT
       LIMITED ....................................        INTERNATIONAL LIMITED
     JPMORGAN ASSET                                     JPMorgan Asset Management                 100.00                     N         934,100 (L)
       MANAGEMENT                                          Holdings Inc.
       INTERNATIONAL LIMITED .....
     JPMorgan Asset Management                          JPMorgan Chase Holdings LLC               100.00                     N       5,001,300 (L)
       Holdings Inc. ..............................



                                                                       196
                                                                                                                          %               Direct interest          Number of
     Name of controlled corporation                            Name of controlling person                               control               (Y/N)                 shares
     JPMorgan Chase Holdings LLC ......                        JPMorgan Chase & Co.                                        100.00                           N     5,397,600 (L)
     JPMorgan Asset Management                                 JPMorgan Asset Management                                   100.00                           N     3,746,100 (L)
        (Asia) Inc. ...................................          Holdings Inc.
     J.P. Morgan Broker-Dealer                                 JPMorgan Chase Holdings LLC                                 100.00                           N       396,300 (L)
        Holdings Inc. ..............................
     JPMorgan Chase Bank, National                             JPMorgan Chase & Co.                                        100.00                           N    11,420,430   (L)
        Association .................................                                                                                                             1,226,000   (S)
     J.P. MORGAN CAPITAL                                       J.P. Morgan International Finance                           100.00                           N     2,656,441   (L)
        HOLDINGS LIMITED................                          Limited                                                                                         1,226,000   (S)
     J.P. Morgan International Finance                         JPMorgan Chase Bank, National                               100.00                           N     2,656,441   (L)
        Limited .......................................           Association                                                                                     1,226,000   (S)

     The capacity under which the interests are held are as follow:

                                                                                                                                                                Number of H
     Capacity in which interest is held                                                                                                                           Shares
     Interest of controlled corporation .........................................................................................................                 1,929,941   (L)
                                                                                                                                                                  1,226,000   (S)
     Invest manager .....................................................................................................................................         5,277,900   (L)
     Person having security interest in the shares........................................................................................                        1,122,800   (L)
     Approved lending agent .......................................................................................................................               8,763,989   (L)

     Additionally, 127,200 (short position) H Shares were held through a physically settled unlisted derivative, and 293,000 (long
     position) H Shares and 1,098,800 H Shares (short position) were held through a cash settled unlisted derivative.

6.   According to the disclosure of interest notice filed by The Capital Group Companies, Inc. with a relevant event date of
     December 27, 2019, it has a total interest of 16,060,700 (long position) Shares in our Company by virtue of its control over
     Capital Research and Management Company.

7.   According to the disclosure of interest notice filed by BlackRock Inc. with a relevant event date of November 30, 2020, the
     following interest in H Shares were held by BlackRock Inc.:

                                                                                                                          %               Direct interest          Number of
     Name of controlled corporation                            Name of controlling person                               control               (Y/N)                 shares
     Trident Merger, LLC .......................               BlackRock, Inc.                                             100.00                           N       100,300 (L)
     BlackRock Investment                                      Trident Merger, LLC                                         100.00                           Y       100,300 (L)
        Management, LLC ......................
     BlackRock Holdco 2, Inc. ...............                  BlackRock, Inc.                                             100.00                           N     9,550,525 (L)
     BlackRock Financial                                       BlackRock Holdco 2, Inc.                                    100.00                           N     8,975,125 (L)
        Management, Inc.........................
     BlackRock Financial                                       BlackRock Holdco 2, Inc.                                    100.00                           Y       575,400 (L)
        Management, Inc.........................
     BlackRock Holdco 4, LLC ..............                    BlackRock Financial                                         100.00                           N     3,549,900 (L)
                                                                 Management, Inc.
     BlackRock Holdco 6, LLC ..............                    BlackRock Holdco 4, LLC                                      90.00                           N     3,549,900 (L)
     BlackRock Delaware Holdings Inc. .                        BlackRock Holdco 6, LLC                                     100.00                           N     3,549,900 (L)
     BlackRock Institutional Trust                             BlackRock Delaware Holdings                                 100.00                           Y     1,667,900 (L)
        Company, National Association...                         Inc.
     BlackRock Fund Advisors ...............                   BlackRock Delaware Holdings                                 100.00                           Y     1,882,000 (L)
                                                                 Inc.
     BlackRock Capital Holdings, Inc. ...                      BlackRock Financial                                         100.00                           N        27,800 (L)
                                                                 Management, Inc.
     BlackRock Advisors, LLC ...............                   BlackRock Capital Holdings, Inc.                            100.00                           N        21,100 (L)
     BlackRock Advisors, LLC ...............                   BlackRock Capital Holdings, Inc.                            100.00                           Y         6,700 (L)
     BlackRock Capital                                         BlackRock Advisors, LLC                                     100.00                           Y        21,100 (L)
        Management, Inc.........................
     BlackRock International                                   BlackRock Financial                                         100.00                           N     5,397,425 (L)
        Holdings, Inc. .............................             Management, Inc.
     BR Jersey International                                   BlackRock International                                       86.00                          N     5,397,425 (L)
        Holdings L.P. ..............................             Holdings, Inc.
     BlackRock Lux Finco S.à r.l. ..........                  BlackRock HK Holdco Limited                                 100.00                           N       561,512 (L)



                                                                                        197
                                                                                              %        Direct interest   Number of
Name of controlled corporation                           Name of controlling person         control        (Y/N)          shares
BlackRock Japan Holdings GK .......                      BlackRock Lux Finco S.à r.l.        100.00                N      561,512 (L)
BlackRock Japan Co., Ltd. ..............                 BlackRock Japan Holdings GK          100.00                Y      561,512 (L)
BlackRock Holdco 3, LLC ..............                   BR Jersey International Holdings     100.00                N    4,650,213 (L)
                                                           L.P.
BlackRock Canada Holdings LP......                       BlackRock Holdco 3, LLC               99.90                N      13,100 (L)
BlackRock Canada Holdings ULC ..                         BlackRock Canada Holdings LP         100.00                N      13,100 (L)
BlackRock Asset Management                               BlackRock Canada Holdings ULC        100.00                Y      13,100 (L)
   Canada Limited ...........................
BlackRock Australia Holdco                               BR Jersey International Holdings     100.00                N      65,800 (L)
   Pty. Ltd. ......................................        L.P.
BlackRock Investment Management                          BlackRock Australia Holdco           100.00                Y      65,800 (L)
   (Australia) Limited......................               Pty. Ltd.
BlackRock (Singapore) Holdco                             BR Jersey International Holdings     100.00                N     681,412 (L)
   Pte. Ltd. ......................................        L.P.
BlackRock HK Holdco Limited.......                       BlackRock (Singapore) Holdco         100.00                N     642,512 (L)
                                                           Pte. Ltd.
BlackRock Asset Management                               BlackRock HK Holdco Limited          100.00                Y      81,000 (L)
   North Asia Limited .....................
BlackRock Cayman 1 LP ................                   BlackRock Holdco 3, LLC              100.00                N    4,637,113 (L)
BlackRock Cayman West Bay                                BlackRock Cayman 1 LP                100.00                N    4,637,113 (L)
   Finco Limited .............................
BlackRock Cayman West Bay IV                             BlackRock Cayman West Bay            100.00                N    4,637,113 (L)
   Limited .......................................         Finco Limited
BlackRock Group Limited ...............                  BlackRock Cayman West Bay IV          90.00                N    4,637,113 (L)
                                                           Limited
BlackRock Finance Europe                                 BlackRock Group Limited              100.00                N    1,624,828 (L)
   Limited .......................................
BlackRock Advisors (UK) Limited..                        BlackRock Finance Europe             100.00                Y      20,500 (L)
                                                           Limited
BlackRock Group                                          BlackRock Group Limited              100.00                N    3,012,285 (L)
   Limited–Luxembourg Branch ......
BlackRock Luxembourg Holdco                              BlackRock Group Limited –           100.00                N     745,685 (L)
   S.à r.l. .........................................     Luxembourg Branch
BlackRock Investment Management                          BlackRock Luxembourg Holdco          100.00                Y     745,685 (L)
   Ireland Holdings Limited ............                   S.à r.l.
BlackRock Asset Management                               BlackRock Investment                 100.00                Y    2,266,600 (L)
   Ireland Limited ...........................             Management Ireland Holdings
                                                           Limited
BLACKROCK (Luxembourg) S.A...                            BlackRock Luxembourg Holdco          100.00                N     843,955 (L)
                                                           S.à r.l.
BlackRock Investment Management                          BlackRock Finance Europe             100.00                Y     760,373 (L)
   (UK) Limited ..............................             Limited
BlackRock Fund Managers                                  BlackRock Investment                 100.00                Y     843,955 (L)
   Limited .......................................         Management (UK) Limited
BlackRock (Singapore) Limited ......                     BlackRock (Singapore) Holdco         100.00                Y      38,900 (L)
                                                           Pte. Ltd.




                                                                         198
8.   According to the disclosure of interest notice filed by FMR LLC. with a relevant event date of December 11, 2020, the following
     interest in H Shares were held by FMR LLC:

                                                                                                              %         Direct interest    Number of
     Name of controlled corporation                           Name of controlling person                    control         (Y/N)           shares
     FIDELITY MANAGEMENT &                                    FMR LLC                                         100.00                 Y       100,000 (L)
       RESEARCH COMPANY LLC ....
     FIDELITY MANAGEMENT &                                    FMR LLC                                         100.00                 N     9,128,636 (L)
       RESEARCH COMPANY LLC ....
     FIDELITY MANAGEMENT &                                    FIDELITY MANAGEMENT &                           100.00                 Y     8,843,436 (L)
       RESEARCH (HONG KONG                                      RESEARCH COMPANY LLC
       LIMITED) ...................................
     FIAM HOLDINGS LLC ..................                     FMR LLC                                         100.00                 N     1,158,229 (L)
     FIDELITY INSTITUTIONAL                                   FIAM HOLDINGS LLC                               100.00                 N     1,153,700 (L)
       ASSET MANAGEMENT
       TRUST COMPANY ....................
     FIAM LLC ......................................          FIAM HOLDINGS LLC                               100.00                 N         4,529 (L)
     FIDELITY ADVISORY                                        FMR LLC                                         100.00                 N       277,600 (L)
       HOLDINGS LLC ........................
     STRATEGIC ADVISERS LLC ........                          FIDELITY ADVISORY                               100.00                 N       277,600 (L)
                                                                HOLDINGS LLC
     FIDELITY CANADA INVESTORS                                OWNED BY CERTAIN                                100.00                 N       259,710 (L)
       LLC ............................................         EMPLOYEES AND
                                                                SHAREHOLDERS OF
                                                                FMR LLC
     BAY STREET HOLDINGS LLC .....                            FIDELITY CANADA                                 100.00                 N       259,710 (L)
                                                                INVESTORS LLC
     483A BAY STREET HOLDINGS                                 BAY STREET HOLDINGS LLC                          18.00                 N       259,710 (L)
       LP ...............................................
     BLUEJAY LUX 1 S.A.R.L. .............                     483A BAY STREET HOLDINGS                        100.00                 N       259,710 (L)
                                                                LP
     FIC HOLDINGS ULC .....................                   BLUEJAY LUX 1 S.A.R.L.                          100.00                 N       259,710 (L)
     FIDELITY INVESTMENTS                                     FIC HOLDINGS ULC                                100.00                 N       259,710 (L)
       CANADA ULC ...........................


9.   According to the disclosure of interest notice filed by China Structural Reform Fund, CCB (Beijing) Investment Fund
     Management Co., Ltd. (        (   )                           ) (“CCB Beijing”), CCB Trust Co., Ltd. (
        ) (“CCB Trust”) and China Post Savings Bank Co., Ltd. (                                ) (“China Post Savings Bank”),
     each with a relevant event date of December 27. 2019, China Structural Reform Fund has a beneficial interest of 7,931,600
     (long position) Shares in our Company and the interest of CCB Beijing, CCB Trust and China Post Savings Banks is as follow:

     as filed by CCB Trust

                                                                                                              %         Direct interest    Number of
     Name of controlled corporation                           Name of controlling person                    control         (Y/N)           shares
     CCB Beijing ....................................         CCB Trust                                       100.00                 N     7,931,600 (L)
     China Structural Reform Fund.........                    CCB Beijing                                      38.20                 Y     7,931,600 (L)


     as filed by China Post Savings Bank Co., Ltd.

                                                                                                                                           Number of
     Names of trust                                                                    Capacity                                            H Shares
     CCB Trust-Wutong Tree Fund Trust Plan                                             Beneficiary of a trust (other than a               7,931,600 (L)
       (asset allocation class 26 investment unit)                                       discretionary interest)
       (           –                                (                  26
              )) ...................................................................




                                                                                       199
Substantial shareholders of other members of the Group

                                                                                                               Approximate
                                                                                                            percentage held by
                                                                                                              the substantial
Name                                                                Member of the Group                         shareholder

WU Yu ........................................................      Nanjing Sirui Biotechnology Co., Ltd.            23.04%
                                                                      (                          )
Nanjing Sanomai Kang Enterprise                                     Nanjing Sirui Biotechnology Co., Ltd.            14.73%
  Management Partnership (Limited                                     (                          )
  Partnership) (
       (           )) .......................................
Nanjing Xiya Enterprise Management                                  Nanjing Sirui Biotechnology Co., Ltd.              6.67%
  Partnership (Limited Partnership) (                                 (                          )
                                (              )) ..........
Shin Nippon Biomedical Laboratories, Ltd .                          Pharmaron CPC, Inc                               20.00%
LIU Yang.....................................................       LinkStart (                                      22.40%
                                                                             )
Beijing Deshu Enterprise Management                                 LinkStart (                                        8.00%
  Center (Limited Partnership) (                                             )
                      (              )).........................
Hainan Shenzhou Deshu No. 1                                         Hainan Shenzhou Deshu Medical                    20.00%
  Management Center (Limited                                          Technology Co., Ltd (
  Partnership) (                                                                       )
  (             )) ..............................................
                                                      (                       (   )                                  15.00%
       ) ........................................................


Save as disclosed above, as of December 31, 2020, to the knowledge of the Directors, no other person had,
or were deemed or taken to have interest or short position in the Shares or underlying Shares which would
fall to be disclosed to the Company under the provisions of Divisions 2 and 3 of Part XV of the SFO, or
which were recorded in the registry kept by the Company pursuant to Section 336 of the SFO.




                                                                        200
                              DESCRIPTION OF THE SHARES

The following information is a summary of certain provisions of the Company’s Articles of Association and
certain other information concerning the Company. These statements are only a summary and qualified in
their entirety by reference to the full Articles of Association of the Company and Company Law of the
People’s Republic of China.

After the establishment of the Company, the Company publicly issued 65,630,000 A Shares with the
approval of the CSRC, which were listed on the Shenzhen Stock Exchange on January 28, 2019.

On October 24, 2019, 4,077,387 Restricted A Shares of the Company were approved for eligible employees
under the A Share Incentive Scheme and the grant date was October 30, 2019. As of November 13, 2019,
4,077,387 A Shares were subscribed by eligible employees.

Subsequently, the Company publicly issued 116,536,100 H Shares with the approval of the CSRC, which
were listed on the Hong Kong Stock Exchange on November 28, 2019. The joint global coordinators of the
listing of H Shares exercised the over-allotment option in full and the Company further issued 17,480,400
H Shares.

After the completion of the above issuance of A Shares and H Shares, the total share capital of the Company
is 794,387,462 Shares, among which 660,370,962 are A Shares, representing 83.13 per cent., and
134,016,500 are H Shares, representing 16.87 per cent., of the total share capital of the Company,
respectively.

The Company proposed to repurchase and cancel 193,024 Restricted A Shares granted under the A Share
Incentive Scheme due to the resignation of the three grantees of such Restricted A Shares in accordance with
the provisions of the A Share Incentive Scheme, and the decrease of number of issued shares of the
Company from 794,387,462 shares to 794,194,438 shares, which were approved by the Company’s
shareholders at the annual general meeting dated May 28, 2021. Subsequently, the total share capital of the
Company became 794,194,438 Shares, among which 660,177,938 are A Shares, representing 83.13 per
cent., and 134,016,500 are H Shares, representing 16.87 per cent., of the total share capital of the Company,
respectively.




                                                    201
                                             TAXATION

The following summary of certain PRC, Hong Kong, and European Union tax consequences of the purchase,
ownership and disposition of the Bonds is based upon applicable laws, regulations, rulings and decisions
in effect as of May 31, 2021, all of which are subject to change (possibly with retroactive effect). This
summary does not purport to be a comprehensive description of all the tax considerations that may be
relevant to a decision to purchase, own or dispose of the Bonds and does not purport to deal with
consequences applicable to all categories of investors, some of which may be subject to special rules.
Neither these statements nor any other statements in this Offering Circular are to be regarded as advice on
the tax position of any holder of the Bonds or any person acquiring, selling or otherwise dealing in the
Bonds or on any tax implications arising from the acquisition, sale or other dealings in respect of the
Bonds.

Persons considering the purchase of the Bonds should consult their own tax advisors concerning the tax
consequences of the purchase, ownership and disposition of the Bonds.

PRC

The following summary describes the principal PRC tax consequences of ownership of the Bonds by
beneficial owners who, or which, are not residents of mainland China for PRC tax purposes (the “non-PRC
Holders”). In considering whether to invest in the Bonds, investors should consult their individual tax
advisors with regard to the application of PRC tax laws to their particular situations as well as any tax
consequences arising under the laws of any other tax jurisdiction.

Taxation of the Bonds

The Issuer is considered a PRC tax resident enterprise for the purpose of the EIT Law and is subject to
enterprise income tax at a rate of 25 per cent. on its income sourced from both within and outside the PRC.
On that basis, Holders will be subject to withholding tax, income tax and other taxes or duties imposed by
relevant government authorities in the PRC in respect of the holding of the Bonds or any repayment of
principal, and premium (if any) and interest (if any) made thereon, as further described below.

Pursuant to the EIT Law and the IIT Law as amended, and their implementation rules, any non-PRC resident
enterprise without an establishment within the PRC or whose income has no actual connection to its
establishment inside the PRC or any non-PRC resident individual who is not residing in the PRC or who
has resided in the PRC for less than 183 days with a tax year, must pay income tax on the PRC-sourced
income, unless a preferential rate is provided by tax treaties or arrangements entered into between the
country or region where the non-resident is established or tax resided and the PRC, and such income tax
must be withheld at source by the PRC payer. Accordingly, the Issuer must withhold income tax from the
payments of redemption premium (if any) and interest (if any) on the Bonds to any non-PRC resident
enterprise Holder and any non-PRC resident individual Holder. The Issuer has agreed to pay additional
amounts to Holders, subject to certain exceptions, so that Holders receive the full amount of the scheduled
payment, as further set out in the Terms and Conditions.

Under the EIT Law and its implementation rules, any gains realized on the transfer of the Bonds by
non-PRC resident enterprise Holders under the EIT Law may be subject to PRC enterprise income tax if
such gains are regarded as PRC-sourced income. If the gains derived from the disposal of the Bonds issued
by a PRC enterprise and held by non-PRC resident enterprise Holders are regarded as PRC-sourced income,
such gain will be subject to PRC enterprise income tax. However, it is not clear under the PRC laws whether
the Bonds are for PRC tax purposes. Therefore, there is uncertainty as to whether gains realized on the
transfer of the Bonds by non-PRC individual Holders will be subject to PRC individual income tax.

In addition, under the IIT Law, individuals who do not have a domicile in the PRC and have not resided
in the PRC, or individuals who do not have a domicile in the PRC but have resided in the PRC for less than
183 days cumulatively within a tax year, shall be deemed as non-resident individuals. Income derived by
non-resident individuals from China shall be subject to individual income tax pursuant to the provisions of
the IIT Law. There is uncertainty as to whether gains realized on the transfer of the Bonds by individual
holders who are not PRC citizens or residents will be subject to PRC individual income tax.


                                                   202
Any PRC tax on interest, redemption premium or transfers of Bonds will apply at a rate of 10 per cent. in
the case of non-PRC enterprises and 20 per cent. in the case of non-PRC individuals unless there is an
applicable tax treaty or arrangement that reduces or exempts such income tax.

The conversion of the Bonds by non-PRC Holders is not subject to PRC income tax.

Taxation of the H Shares

Taxation of Dividends on H Shares

According to the Notice Regarding Questions on Withholding Enterprise Income tax When PRC Resident
Enterprises Distribute Dividends to Non-resident Enterprise Shareholders of H Shares (Guoshuihan [2008]
No. 897) (                            H
(       [2008]897 )) issued by the SAT, which became effective on November 6, 2008, PRC issuers
should withhold enterprise income tax at a rate of 10% when they distribute dividends to non-resident
enterprise shareholders of H Shares. Non-resident enterprise investors in H-shares can file an application
with the PRC tax authorities to apply any tax treatments in accordance with applicable tax agreements (or
arrangements). Such investors will be required to provide materials proving that they are the beneficial
owners that meet the requirements of any such tax treatments.

According to the IIT Law as amended, and its implementation rules, dividends paid by PRC companies to
individual shareholders are generally subject to a PRC withholding tax levied at a flat rate of 20%. Pursuant
to the Notice on Matters Concerning the Levy and Administration of Individual Income Tax following the
Repeal of Guo Shui Fa [1993] No. 45 (Guo Shui Han [2011] No. 348) (
[1993]045                                                     (      [2011]348 )) issued by the SAT, if a
domestic non-foreign-invested enterprise issues its shares in Hong Kong, its non PRC resident individual
shareholders may be entitled to preferential tax treatments in accordance with the applicable tax treaties and
arrangements. Generally, the distribution of dividends by a domestic non-foreign-invested enterprise whose
shares are issued and listed in Hong Kong is subject to a withholding individual income tax of 10% and
there is no need to apply to the PRC tax authorities to qualify for this rate. If the tax rate specified in the
relevant tax treaty or arrangement is lower than 10%, an individual shareholder who receives dividends may
apply to the PRC tax authorities for a refund of the excess amount withheld. In accordance with the PRC
laws, if an individual shareholder is a resident of a country which has entered into a tax treaty with the PRC
and the agreed tax rate is higher than 10% but lower than 20%, his dividend will be subject to income tax
at the agreed tax rate. If an individual shareholder is a resident of a country which has not entered into a
tax treaty with the PRC, his dividend will be subject to income tax at a tax rate of 20%. The Issuer will
withhold tax from any dividend payment at the applicable tax rate (which may be higher than 10% if the
relevant individual shareholders and the tax rate applicable to such shareholder can be identified by the
Issuer).

Taxation of Capital Gains related to transfer of H Shares

According to the EIT Law and its implementation rules, a non-resident enterprise is generally subject to
enterprise income tax at a rate of 10% with respect to its PRC-sourced income, including the gains derived
from the disposal of equity interests in a PRC enterprise. Such tax may be reduced or eliminated under
applicable tax treaties.

According to the IIT Law and its implementation rules, individuals are subject to individual income tax at
the rate of 20% on gains realized on the sale of equity interests in PRC resident enterprises. Under the
Circular Declaring that Individual Income Tax Continues to Be Exempted over Income of Individuals from
Transfer of Shares (Cai Shui Zi [1998] No. 61) (
                          (       [1998]61 )) issued by the MOF and the SAT on March 30, 1998, from
January 1, 1997, income of individuals from the transfer of shares in listed enterprises continues to be
exempted from individual income tax. After the latest amendment to the IIT Law, the SAT has not explicitly
stated whether it will continue to exempt individual income tax on income derived by individuals from the


                                                     203
transfer of listed shares. However, on December 31, 2009, the MOF, the SAT and the CSRC jointly issued
the Circular on Related Issues on Collection of Individual Income Tax over the Income Received by
Individuals from Transfer of Listed Shares Subject to Sales Limitation (Cai Shui [2009] No. 167) (
                                                                  (     [2009]167 )) and Supplementary
Notice of the Circular on Related Issues on Collection of Individual Income Tax over the Income Received
by Individuals from Transfer of Listed Shares Subject to Sales Limitation (Cai Shui [2010] No. 70) (
                                                                          (    [2010]70 )), which provides
that individuals’ income from transferring listed shares on certain domestic exchanges generally will
continue to be exempted from the individual income tax. The aforementioned provision has not expressly
provided that individual income tax shall be collected from non-PRC resident individuals on gains from the
sale of shares of PRC resident enterprises listed on overseas stock exchanges. However, there is no
assurance that the PRC tax authorities will not change these practices, which could result in levying income
tax on non-PRC resident individuals on gains from the sale of H Shares.

Tax Arrangements and Treaties

According to the Arrangement between the Mainland of China and the Hong Kong Special Administrative
Region for the Avoidance of Double Taxation and the Prevention of Fiscal Evasion (
                                                      ) with respect to taxes on income signed on August
21, 2006, the PRC tax authorities may impose tax on dividends payable by a PRC company to a Hong Kong
resident, but such tax shall not exceed 10% of the gross amount of dividends payable, and in the case where
a Hong Kong resident beneficially owns at least 25% equity interest in a PRC company, such tax shall not
exceed 5% of the gross amount of dividends payable by the PRC company.

Investors who do not reside in the PRC and reside in countries that have entered into avoidance of double
taxation treaties with the PRC may be entitled to a reduction of the tax imposed on payments to investors
in the Company who do not reside in the PRC. The PRC currently has double-taxation treaties with many
nations in the world, which include but not limited to Australia, Canada, France, Germany, Japan, Malaysia,
the Netherlands, Singapore, the United Kingdom and the United States.

Stamp duty

Except for the PRC stamp duty on booking capital account (                     ) which must be paid by the
Issuer as a result of the issuance of H Shares on the conversion of the Bonds, no PRC stamp duty will be
chargeable upon the issue or transfer of the Bonds or H Shares (if the register of the Holders is maintained
outside the PRC and the issue or transfer of the Bonds or H Shares are made outside of the PRC).

Hong Kong

Withholding tax

No withholding tax is payable in Hong Kong in respect of payments of principal (including any premium
payable on redemption of the Bonds) or interest on the Bonds.

Stamp duty

No Hong Kong stamp duty will be chargeable upon the issue and transfer of a Bond.

The Proposed Financial Transactions Tax (“FTT”)

On February 14, 2013, the European Commission published a proposal (the “Commission’s Proposal”) for
a Directive for a common FTT in Belgium, Germany, Estonia, Greece, Spain, France, Italy, Austria,
Portugal, Slovenia and Slovakia (the “participating Member States”). However, Estonia has since stated
that it will not participate.

The Commission’s Proposal has very broad scope and could, if introduced, apply to certain dealings in the
Bonds (including secondary market transactions) in certain circumstances.


                                                    204
Under the Commission’s Proposal the FTT could apply in certain circumstances to persons both within and
outside of the participating Member States. Generally, it would apply to certain dealings in the Bonds where
at least one party is a financial institution, and at least one party is established in a participating Member
State. A financial institution may be, or be deemed to be, “established” in a participating Member State in
a broad range of circumstances, including (a) by transacting with a person established in a participating
Member State or (b) where the financial instrument which is subject to the dealings is issued in a
participating Member State.

However, the FTT proposal remains subject to negotiation between participating Member States. It may
therefore be altered prior to any implementation, the timing of which remains unclear. Additional EU
Member States may decide to participate.

Prospective Bondholders are advised to seek their own professional advice in relation to the FTT.




                                                     205
                                                  SUBSCRIPTION AND SALE

The Issuer has entered into a subscription agreement with the Joint Lead Managers dated June 8, 2021 (the
“Subscription Agreement”), pursuant to which and subject to certain conditions contained therein, the
Issuer has agreed to sell to the Joint Lead Managers, and the Joint Lead Managers have agreed to subscribe
and pay for, or to procure subscribers to subscribe and pay for, the Bonds in the amounts set forth opposite
their respective names below:

                                                                                                        Principal amount   Principal amount
                                                                                                         of the Series 1    of the Series 2
                                                                                                           Bonds to be        Bonds to be
Joint Lead Managers                                                                                        subscribed         subscribed
                                                                                                             (US$)             (RMB)
Goldman Sachs (Asia) L.L.C...........................................................                      180,000,000      1,149,600,000
CLSA Limited .................................................................................              99,000,000        632,280,000
J.P. Morgan Securities plc ...............................................................                  21,000,000        134,120,000
Total................................................................................................      300,000,000      1,916,000,000


The Issuer has agreed with the Joint Lead Managers in the Subscription Agreement that for the period of
90 days after the Issue Date (both dates inclusive), neither the Issuer nor any person acting on its behalf
will, without the prior written consent of the Joint Lead Managers, (a) issue, offer, sell, pledge, encumber,
contract to sell or otherwise dispose of or grant options, issue warrants or offer rights entitling persons to
subscribe or purchase any interest in any Shares or securities of the same class as the Bonds or the Shares
or any securities convertible into, exchangeable for or which carry rights to subscribe or purchase the
Bonds, the Shares or securities of the same class as the Bonds, the Shares or other instruments representing
interests in the Bonds, the Shares or other securities of the same class as them, (b) enter into any swap or
other agreement that transfers, in whole or in part, any of the economic consequences of the ownership of
the Shares, (c) enter into any transaction with the same economic effect as, or which is designed to, or which
may reasonably be expected to result in, or agree to do, any of the foregoing, whether any such transaction
of the kind described in (a), (b) or (c) is to be settled by delivery of Shares or other securities, in cash or
otherwise or (d) announce or otherwise make public an intention to do any of the foregoing, provided that
this restriction shall not apply to (i) the Bonds and the New Shares issued on conversion of the Bonds, or
(ii) any Shares or other securities (including rights or options) which are issued, offered, exercised, allotted,
appropriated, modified or granted to, or for the benefit of employees (including directors) of the Issuer or
any of its subsidiaries pursuant to any employee share scheme or plan.

The Subscription Agreement provides that the Issuer will indemnify the Joint Lead Managers against certain
liabilities in connection with the offer and sale of the Bonds. The Subscription Agreement provides that the
obligations of the Joint Lead Managers are subject to certain conditions precedent, and entitles the Joint
Lead Managers to terminate it in certain circumstances prior to payment for the Bonds being made to the
Issuer.

The Joint Lead Managers and their respective subsidiaries affiliates are full service financial institutions
engaged in various activities, which may include securities trading, commercial and investment banking,
financial advisory, investment management, principal investment, hedging, financing and brokerage
activities. The Joint Lead Managers and their respective affiliates have, from time to time, performed, and
may in the future perform, various financial advisory and investment banking services for, and have entered,
and may in the future enter, into certain commercial banking transactions with, and have performed, and
may in the future perform services for the Issuer, the Group and/or their respective subsidiaries and
affiliates in the ordinary course of their business for which they have received or will receive customary
fees and expenses.




                                                                            206
The Joint Lead Managers and their respective affiliates may purchase the Bonds and be allocated Bonds for
asset management and/or proprietary purposes but not with a view to distribution. References herein to the
Bonds being offered should be read as including any offering of the Bonds to the Joint Lead Managers
and/or their affiliates acting in such capacity. In the ordinary course of their various business activities, the
Joint Lead Managers and their respective affiliates may make or hold a broad array of investments and
actively trade debt and equity securities (or related derivative securities) and financial instruments
(including bank loans) for their own account and for the accounts of their customers and may at any time
hold long and short positions and enter into transactions, including credit derivative, such as asset swaps,
repackaging and credit default swaps relating to the Bonds and/or other securities of their or their respective
subsidiaries or associates at the same time as the offer and sale of the Bonds or in secondary market
transactions. Such investment and securities activities may involve securities and instruments of the Issuer
and such transactions would be carried out as bilateral trades with selected counterparties and separately
from any existing sale or resale of the Bonds to which this Offering Circular relates (notwithstanding that
such selected counterparties may also be purchasers of the Bonds). Such persons do not intend to disclose
the extent of any such investment or transactions otherwise than in accordance with any legal or regulatory
obligation to do so.

No action has been or will be taken that would, or is intended to, permit a public offering of the Bonds, or
the possession or distribution of this Offering Circular or any amendment or supplement thereto or any
offering or publicity material relating to the Bonds, in any country or jurisdiction where action for that
purpose is required.

Accordingly, the Bonds should not be offered or sold, directly or indirectly, and neither this Offering
Circular nor any other offering material, circular, prospectus, form of application or advertisement in
connection with the Bonds should be distributed or published in or from any jurisdiction except in
circumstances which will result in compliance with any applicable laws and regulations and will not, save
as disclosed in this Offering Circular, impose any obligations on the Issuer or the Joint Lead Managers.

The distribution of this Offering Circular or any offering material and the offering, sale or delivery of the
Bonds is restricted by law in certain jurisdictions. Therefore, persons who may come into possession of this
Offering Circular or any offering material are advised to consult with their own legal advisers as to what
restrictions may be applicable to them and to observe such restrictions. This Offering Circular may not be
used for the purpose of an offer or invitation in any circumstances in which such offer or invitation is not
authorized.

Selling Restrictions

General

None of the Issuer nor the Joint Lead Managers makes any representation that any action has been or will
be taken in any jurisdiction by the Joint Lead Managers or the Issuer that would permit a public offering
of the Bonds, or possession or distribution of this Offering Circular or any other offering or publicity
material relating to the Bonds (including roadshow materials and investor presentations), in any country or
jurisdiction where action for that purpose is required. Each of the Joint Lead Managers will comply to the
best of its knowledge and belief in all material respects with all applicable securities laws and regulations
in each jurisdiction in which they offer, sell or deliver Bonds or have in their possession or distribute this
Offering Circular or any amendment or supplement thereto. The Issuer and the other Joint Lead Managers
will have no responsibility for, and each Joint Lead Manager will obtain any consent, approval or
permission required by it for, the offer, sale or delivery by it of Bonds under the laws and regulations in
force in any jurisdiction to which it is subject or in or from which it makes any offer, sale or delivery. None
of the Joint Lead Managers is authorized to make any representation or use any information in connection
with the issue, subscription and sale of the Bonds other than as contained in, or which is consistent with,
this Offering Circular or any amendment or supplement to it.

If a jurisdiction requires that the offering of the Bonds be made by a licensed broker or dealer and a Joint
Lead Manager or any affiliate of that Joint Lead Managers is a licensed broker or dealer in that jurisdiction,
the offering of the Bonds shall be deemed to be made by that Joint Lead Manager or its affiliate on behalf
of the Issuer in such jurisdiction.


                                                      207
United States

The Bonds and the Shares to be issued upon conversion of the Bonds have not been and will not be
registered under the Securities Act and may not be offered or sold within the United States except pursuant
to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act.
Each of the Joint Lead Managers has represented and warranted that it has not offered or sold, and agrees
that it will not offer or sell, any Bonds constituting part of its allotment within the United States except in
accordance with Rule 903 of Regulation S under the Securities Act. Accordingly, neither it, its affiliates nor
any persons acting on its or their behalf have engaged or will engage in any directed selling efforts with
respect to the Bonds or the Shares to be issued upon conversion of the Shares. Terms used in this paragraph
have the meaning given to them by Regulation S under the Securities Act.

United Kingdom

Each of the Joint Lead Managers has represented, warranted and agreed that:

(a)    it has only communicated or caused to be communicated, and will only communicate or cause to be
       communicated any invitation or inducement to engage in investment activity (within the meaning of
       Section 21 of the Financial Services and Markets Act 2000 (the “FSMA”)) received by it in
       connection with the issue or sale of the Bonds in circumstances in which Section 21(1) of the FSMA
       does not apply to the Issuer; and

(b)    it has complied and will comply with all applicable provisions of the FSMA with respect to anything
       done by it in relation to the Bonds in, from or otherwise involving the United Kingdom.

PRC

Each Joint Lead Manager has represented, warranted and agreed that the Bonds are not being offered or sold
and may not be offered or sold, directly or indirectly, in the People’s Republic of China (for such purposes,
not including the Hong Kong and Macau Special Administrative Regions or Taiwan), except as permitted
by the securities laws of the People’s Republic of China.

Hong Kong

Each Joint Lead Manager has represented and agreed that:

(i)    it has not offered or sold and will not offer or sell in Hong Kong, by means of any document, any
       Bonds other than (a) to “professional investors” as defined in the Securities and Futures Ordinance
       (Cap. 571 of the laws of Hong Kong) (the “SFO”) and any rules made thereunder; or (b) in other
       circumstances which do not result in the document being a “prospectus” as defined in the Companies
       (Winding Up and Miscellaneous Provisions) Ordinance (Cap. 32 of the laws of Hong Kong) (the
       “C(WUMP)O”) or which do not constitute an offer to the public within the meaning of the
       C(WUMP)O; and

(ii)   it has not issued or had in its possession for the purposes of issue, and will not issue or have in its
       possession for the purposes of issue, whether in Hong Kong or elsewhere, any advertisement,
       invitation or document relating to the Bonds, which is directed at, or the contents of which are likely
       to be accessed or read by, the public of Hong Kong (except if permitted to do so under the securities
       laws of Hong Kong) other than with respect to Bonds which are or are intended to be disposed of only
       to persons outside Hong Kong or only to “professional investors” as defined in the SFO and any rules
       made thereunder.

Singapore

Each Joint Lead Manager has acknowledged that this Offering Circular has not been registered as a
prospectus with the Monetary Authority of Singapore. Accordingly, each Joint Lead Manager has


                                                     208
represented and agreed that it has not offered or sold any Bonds or caused such Bonds to be made the
subject of an invitation for subscription or purchase and will not offer or sell such Bonds or cause such
Bonds to be made the subject of an invitation for subscription or purchase, and has not circulated or
distributed, nor will it circulate or distribute, this Offering Circular or any other document or material in
connection with the offer or sale, or invitation for subscription or purchase, of such Bonds, whether directly
or indirectly, to persons in Singapore other than (i) to an institutional investor as defined in Section 4A of
the SFA pursuant to Section 274 of the SFA, (ii) to a relevant person (as defined in Section 275(2) of the
SFA) pursuant to Section 275(1) of the SFA, or any person pursuant to Section 275(1A) of the SFA, and
in accordance with the conditions specified in Section 275 of the SFA, or (iii) otherwise pursuant to, and
in accordance with the conditions of, any other applicable provision of the SFA.

Where Bonds are subscribed or purchased under Section 275 of the SFA by a relevant person which is:

(a)   a corporation (which is not an accredited investor (as defined in Section 4A of the SFA)) the sole
      business of which is to hold investments and the entire share capital of which is owned by one or more
      individuals, each of whom is an accredited investor; or

(b)   a trust (where the trustee is not an accredited investor) whose sole purpose is to hold investments and
      each beneficiary of the trust is an individual who is an accredited investor,

securities or securities-based derivatives contracts (each term as defined in Section 2(1) of the SFA) of that
corporation or the beneficiaries’ rights and interest (howsoever described) in that trust shall not be
transferred within six months after that corporation or that trust has acquired the Bonds pursuant to an offer
made under Section 275 of the SFA except:

(iii) to an institutional investor or to a relevant person, or to any person arising from an offer referred to
      in Section 275(1A) or Section 276(4)(i)(B) of the SFA;

(iv) where no consideration is or will be given for the transfer;

(v)   where the transfer is by operation of law;

(vi) as specified in Section 276(7) of the SFA; or

as specified in Regulation 37A of the Securities and Futures (Offers of Investments) (Securities and
Securities-based Derivatives Contracts) Regulations 2018.Singapore SFA Product Classification: In
connection with Section 309B of the SFA and the CMP Regulations 2018, the Issuer has determined, and
hereby notifies all relevant persons (as defined in Section 309A(1) of the SFA), that the Bonds are
‘prescribed capital markets products’ (as defined in the CMP Regulations 2018) and Excluded Investment
Products (as defined in MAS Notice SFA 04-N12: Notice on the Sale of Investment Products and MAS
Notice FAA-N16: Notice on Recommendations on Investment Products).

Japan

The Bonds have not been and will not be registered under the Financial Instruments and Exchange Act of
Japan (Act No. 25 of 1948, as amended, the “Financial Instruments and Exchange Act”). Accordingly,
each Joint Lead Manager has represented and agreed that it has not, directly or indirectly, offered or sold
and will not, directly or indirectly, offer or sell any Bonds in Japan or to, or for the benefit of, any resident
of Japan (which term as used herein means any person resident in Japan, including any corporation or other
entity organized under the laws of Japan) or to others for re-offering or re-sale, directly or indirectly, in
Japan or to, or for the benefit of, any resident of Japan except pursuant to an exemption from the registration
requirements of, and otherwise in compliance with, the Financial Instruments and Exchange Act and other
relevant laws and regulations of Japan.

Cayman Islands

Each Joint Lead Manager has represented, warranted and agreed that no offer of the Bonds will be made
directly or indirectly to the public in the Cayman Islands.


                                                      209
                                  GENERAL INFORMATION

1.   Clearing Systems: The Bonds have been accepted for clearance through Euroclear and Clearstream.
     The Legal Entity Identifier of the Issuer is 300300JYXHGVS5SNGG54. The Common Code of the
     Series 1 Bonds is 235239574 and the International Securities Identification Number of the Series 1
     Bonds is XS2352395748. The Common Code of the Series 2 Bonds is 235301172 and the International
     Securities Identification Number of the Series 2 Bonds is XS2353011724.

2.   Authorizations: The Company has obtained all necessary consents, approvals and authorizations in
     connection with the issue of and performance of its obligations under the Bonds, the Trust Deed and
     the Agency Agreement. The issue of the Bonds and the right of conversion into Shares was authorized
     by the resolutions of the Board of Directors passed on June 4, 2021 and the issue of the Shares upon
     conversion of the Bonds was authorized by the general mandate granted to the Board by the
     Shareholders on May 28, 2021.

3.   No Material Adverse Change: There has been no material adverse change, or any development or
     event likely to involve a prospective change, in the condition (financial or otherwise), trading
     position, prospects, results of operations, business or general affairs of the Company or the Group
     since December 31, 2020.

4.   Litigation: From time to time, the Company and other members of the Group may be involved in
     litigation or other disputes that arise in the ordinary course of business. However, none of the
     Company or any member of the Group is currently involved in any litigation, disputes or arbitration
     proceedings which the Group believes are material in the context of the Bonds, and the Company is
     not aware of any material litigation, disputes or arbitration proceedings that are currently pending or
     threatened.

5.   Listing of Bonds: Application will be made to the Hong Kong Stock Exchange for the listing of, and
     permission to deal in, the Bonds on the Hong Kong Stock Exchange by way of debt issues to
     Professional Investors only and formal permission is expected to become effective on June 21, 2021.

6.   Listing of Shares: Application will be made to the Hong Kong Stock Exchange for the listing of, and
     permission to deal in, the Shares to be issued upon conversion of the Bonds.

7.   Available Documents: As long as any of the Bonds are outstanding, copies of the Trust Deeds, the
     Agency Agreements and the Calculation Agency Agreement will be available for inspection to
     Bondholders at all reasonable times during normal business hours (being between 9:00 a.m. and 3:00
     p.m.) following prior written request and proof of holding and identity satisfactory to the Principal
     Agent at the specified office of the Principal Agent, and, in the case of the documents referred to
     below, copies may be obtained during normal business hours at the specified office of the Issuer at
     the office of O’Melveny & Myers at 31/F, AIA Central, 1 Connaught Road Central, Hong Kong:

           Articles of Association of the Company;

           copies of the audited consolidated financial statements of the Company as of and for the years
           ended December 31, 2019 and 2020;

           the Agency Agreements;

           the Trust Deeds; and

           the Calculation Agency Agreement.

8.   Independent Auditors: The Company’s consolidated audited financial statements as of and for the
     years ended December 31, 2019 and 2020 have been audited by Ernst & Young, Certified Public
     Accountants, Hong Kong.

The independent auditors of the Company have agreed to the incorporation by reference in this Offering
Circular of, and all references to, (i) their name, (ii) their audit reports on the consolidated financial
statements of the Company for the years ended December 31, 2019 and 2020.


                                                   210
                                        ISSUER

                            Pharmaron Beijing Co., Ltd
                       (         (     )                    )
                          8th Floor, Block 1, 6 Tai-He Road
                 Beijing Economic Technological Development Zone
                                    Beijing, China

                                       TRUSTEE

                           Citicorp International Limited
                           20/F, Citi Tower, One Bay East
                           83 Hoi Bun Road, Kwun Tong
                                      Hong Kong

  PRINCIPAL PAYING AGENT, PRINCIPAL CONVERSION AGENT, PRINCIPAL
                  TRANSFER AGENT AND REGISTRAR

                            Citibank, N.A. London Branch
                           c/o Citibank, N.A. Dublin Branch
                           Ground Floor, 1 North Wall Quay
                                       Dublin 1
                                         Ireland

                                CALCULATION AGENT

                               Conv-Ex Advisors Limited
                                    30 Crown Place
                                  London EC2A 4EB
                                   United Kingdom

                       LEGAL ADVISERS TO THE ISSUER

     As to Hong Kong law                                      As to PRC law

     O’Melveny & Myers                                    Zhong Lun Law Firm
       31/F, AIA Central                             23-31/F, South Tower of CP Center
   1 Connaught Road, Central                               20 Jin He East Avenue
          Hong Kong                                           Chaoyang District
                                                               Beijing 100020
                                                                 P.R. China

             LEGAL ADVISERS TO THE JOINT LEAD MANAGERS

As to Hong Kong and English law                               As to PRC law

Freshfields Bruckhaus Deringer                                 JunHe LLP
     55/F, One Island East                             26F, HKRI Centre One, HKRI
   Taikoo Place, Quarry Bay                        Taikoo Hui, 288 Shimen Road (No. 1)
           Hong Kong                                         Shanghai, China

                      LEGAL ADVISOR TO THE TRUSTEE

                           Freshfields Bruckhaus Deringer
                                55/F, One Island East
                              Taikoo Place, Quarry Bay
                                      Hong Kong

                            INDEPENDENT AUDITORS

                                      Ernst & Young
                                  27/F, One Taikoo Place
                               979 King’s Road, Quarry Bay
                                        Hong Kong