意见反馈 手机随时随地看行情
  • 公司公告

公司公告

康龙化成:H股公告2022-08-30  

                                                 Pharmaron Beijing Co., Ltd.*


                                                  3759

                        2022    6     30



                                                              6    30
                                                    2022            2021
                                                                                        %

                                                  4,634,585        3,285,511          41.1
                                                  1,613,111        1,189,711          35.6
                                                    585,432          564,837           3.6

                                                   812,106          651,392           24.7
                                                   858,787          845,064            1.6

                                                     4,634.6                    2021       6
         30                            1,349.1           41.1%

                                                           585.4                 2021
     6    30                    3.6%

                                                                   858.8
     2021      6   30                      1.6%

                               2022    6    30

                                                                               2022    6
30                                                2021

                                             1
2022   6   30

                                      6 30
                                     2022          2021



                              4    4,634,585     3,285,511
                                  (3,021,474)   (2,095,800)

                                  1,613,111     1,189,711

                              5     220,661       119,881
                              5    (146,209)     (109,595)
                                   (108,110)      (63,733)
                                   (661,073)     (383,583)
                                    (83,669)      (64,464)
                ╱ 撥回              (6,339)          472
                                    (81,235)      (15,786)
                                     (4,439)       (6,993)

                              6     742,698       665,910
                              7    (177,398)     (118,610)

                                    565,300       547,300



                                    585,432       564,837
                                    (20,132)      (17,537)

                                    565,300       547,300




                              9      0.4941        0.4751



                              9      0.4939        0.4747


                          2
2022   6   30

                          6 30
                         2022       2021




                         565,300    547,300




                ╱
                         (27,846)   (28,626)

                         (10,307)    10,947

                         (38,153)   (17,679)

                         (38,153)   (17,679)

                         527,147    529,621



                         548,419    547,136
                         (21,272)   (17,515)

                         527,147    529,621




                     3
2022   6   30
                            2022        2021
                           6 30       12 31



                          6,516,770    5,577,904
                          1,177,845      726,800
                          2,535,957    2,096,265
                            229,329      227,163
                            597,363      452,606
                            248,311      310,063
                            193,584      143,233
                             34,418       15,595
                            431,624      195,993
                         11,965,201    9,745,622

                            285,032      181,700
                            197,271      165,625
                    10    1,616,062    1,228,849
                            276,401      194,981
                            441,403      332,715
                            739,186    1,441,191
                            587,004    1,537,947
                             10,631       16,674
                            111,940       17,243
                          2,736,741    3,526,577
                          7,001,671    8,643,502

                            489,669      482,302
                    11      466,382      315,534
                          1,352,082    1,327,910
                              9,449            –
                            836,714      679,621
                            134,552       95,292
                            106,483       81,337
                          3,395,331    2,981,996
                          3,606,340    5,661,506
                         15,571,541   15,407,128


                4
            2022         2021
           6 30        12 31



            583,955       956,095
            205,245       173,300
             92,614        81,559
            158,507       149,439
          3,614,049     3,467,090
            628,051       284,338

          5,282,421     5,111,821

         10,289,120    10,295,307


    12    1,191,068       794,177
           (484,161)     (301,825)
            198,554       198,554
          9,250,119     9,438,335

         10,155,580    10,129,241

           133,540       166,066

         10,289,120    10,295,307




5
      2022        6   30

1.

                                               2004         7    1
                                                                                              2019   1
      28                                      300759.SZ                2019 11     28
                                                                     3759.HK
                                     6   1     8




                                                                                   CMC             CDMO


2.1

            2022 6         30
              34
                                                   2021         12   31




2.2

                                                                              2021       12   31




                                3
                                16           2021       6   30
                           16
                           37
                                                                          1
           2018       2020                          9                                16
                                                                              41




                                              6
a)                   3                           2018       6

                              3
                                                                                  37
                     21
                                                        3                                   37
                              21
                                                      2022      1   1




b)              16


                   2021 1 1
                 2021 1 1



c)              37                                                      37




                                  2022       1    1




d)                            2018       2020                                     1
            9                               16                                         41


                          9


                                                 2022   1       1




                          16                                                 16             13
                                                                                            16



                                                                             16
        9


                                         7
3.



     
                     (CADD)



         CMC        CDMO



     



                                                                                 (CDMO)
                                                                (CDMO)

     




                                               CMC

        2022 6 30                         CDMO




                              2,860,148   1,084,625   584,537     95,470     9,805   4,634,585

                              1,242,702    356,932     29,883     (18,938)   2,532   1,613,111



                                                                                      220,661
                                                                                     (146,209)
                                                                                     (108,110)
                                                                                     (661,073)
                                                                                      (83,669)
                                                                                       (6,339)
                                                                                      (81,235)
                                                                                       (4,439)

                                                                                      742,698

                                           8
                                  CMC

      2021 6 30               CDMO




                  2,027,048   762,243   422,691   71,661      1,868     3,285,511

                   848,521    278,517    59,614    2,159       900      1,189,711



                                                                         119,881
                                                                        (109,595)
                                                                         (63,733)
                                                                        (383,583)
                                                                         (64,464)
                                                                             472
                                                                         (15,786)
                                                                          (6,993)

                                                                         665,910




(a)

                                                      6 30
                                                     2022               2021




                                                  3,042,305           2,136,045
                                                    629,646             564,435
                                                    112,287              77,995
                                                    819,977             492,991
                                                     30,370              14,045

                                                  4,634,585           3,285,511




                              9
     (b)

                                   2022             2021
                               6     30        12     31



                              8,353,308        6,680,284
                              1,408,274        1,318,092
                              1,892,290        1,386,584
                                 28,600           35,004

                             11,682,472        9,419,964




4.


                                    6 30
                                   2022             2021



                              4,634,585        3,283,643

                                          –         1,868

                              4,634,585        3,285,511



     (a)

                                    6 30
                                   2022             2021




                              2,860,148        2,027,048
           CMC   CDMO         1,084,625          762,243
                                584,537          422,691
                                 95,470           71,661
                                  9,805                –

                              4,634,585        3,283,643


                              2,454,749        1,776,503
                              2,179,836        1,507,140

                              4,634,585        3,283,643
                        10
     (b)

                                        FTE    FFS

           FTE
                                  15
                       FTE

                 FFS


5.

                                         6 30
                                        2022          2021




                                        23,302        19,884

                                          5,932        5,930
                                          9,627       17,584

                                        38,861        43,398


                                             –       17,057
                                       180,190             –
                                             –       27,705
                                             –        5,918

                                              –      25,452
                                            492            –
                                          1,118          351

                                       181,800        76,483

                                       220,661       119,881



                                        (36,844)       (2,961)
                                           (167)         (872)
                                         (8,179)            –
                                         (1,446)            –
                                        (80,728)            –
                                        (11,055)     (100,395)
                                         (7,790)       (5,367)

                                       (146,209)     (109,595)

                             11
6.



                      6 30
                     2022        2021




                    265,257     207,380
                     60,085      49,459
                                    344
                     15,081      12,108
          *

                   1,667,264   1,106,238
              **
                     442,111     310,516
                      52,062      25,720

                                 (25,452)
                   (180,190)           –
                       (492)           –
                      8,179      (27,705)

                     80,728     (17,057)
                      2,543       1,252
                      6,339        (472)
                      1,446      (5,918)
                     11,055     100,395
                      2,380       2,150


     *



     **




              12
7.

                                                                          6 30
                                                                         2022        2021




                                                                     164,173         119,638
                                                                      13,225          (1,028)

                                                                     177,398         118,610


8.

     2022   5   31                                         2021                             A
       H                  2021   12   31                                  0.45
                357,320,000                2022   6   30            301,118,000

                                                                  2021    6     30



9.



                                                                          6 30
                                                                         2022        2021




                                                                     585,432         564,837
                                                                        (501)           (694)
                                                                     584,931         564,143



                                                                              501       347

                                                                     585,432         564,490




                                            13
                                                               6 30
                                                              2022             2021




                                                      1,183,746,632      1,187,504,118



                                                           1,601,168        1,558,409

                                                      1,185,347,800      1,189,062,527


          2022    3   28                   2022   5   31
                           10   5                          397,023,000




10.



                                                             2022             2021
                                                            6 30            12 31




      1                                                    1,603,490        1,209,375
      1   2                                                   12,572           19,474

                                                           1,616,062        1,228,849


                                         8,494,000     2021    12      31
      7,366,000




                                    14
11.




                                                   2022              2021
                                                  6 30             12 31




      1                                            459,574          309,449
           1                                         6,808            6,085

                                                   466,382          315,534


          2022 6     30                              2021     12   31
            4,000         30

12.

                                                   2022              2021
                                                  6 30             12 31




                                                 1,191,068          794,177




          2021   12 31    2022   1   1         794,177,098          794,177
                   A                              (132,012)            (132)
                                               397,022,543          397,023

          2022   6   30                       1,191,067,629        1,191,068




                                         15
A.

     1.




                                                     CMC       CDMO


B.

     1.

          2022




                                                             4,634.6
                            41.1%
                         1,613.1                     34.8%
                                             585.4
            3.6%
          812.1                      24.7%
                                    177.4                    49.6%
                                                               2022    6
            30             17,650
          15,820             89.6%
          2021 12   31   2,365




                                    16
                                                              90%
                20
                20                                                 14.4%
                              2022                           400
                                     65.6%
        13.6%                           17.7%
     3.1%




                                                                       1,314.2
                        27.0%
                CMC       CDMO
                                         853.6
                               11                    1,300                 2022
                                                   12.1%


                                                                     5
                                                                   Science Based
     Targets initiative   SBTi                   2022    6    22
                (SBTi Commitment Letter)




                       SBTi


2.

     (1)

                                                             2,860.1
                        41.1%                    43.4%                            1.5

           73.9%                                   11.3%
               11.7%                              3.1%



                                    17
   2022   6 30                                            8,492
  2021    12 31         1,356
5,800




                                  47.5%                  1.8




                                                   576

                                                          (IND)
(NDA)                  52
                48                               (IND)




          120,000                         2021
                                 42,000

        2,000               105,000
                2024
                                                          140,000
                                     2024




                        100%




                            18
(2) CMC            CDMO

                      CMC           CDMO
   1,084.6                            42.3%                   32.9%
              3.6                                                     CMC
           CDMO          64.8%
      20.1%                   13.1%
      2.0%               CMC          CDMO
            CMC       CDMO                2022                6 30
      CMC         CDMO              3,601                      2021   12
   31       980


                                                 CMC               CDMO
          76%




                                                               714
                500         I-II   182            III   22
                10


                81,000                         2021
                                         600                 200
   2022                     400                 2022
                    2022 1        7                       Cramlington
   Aesica Pharmaceuticals Limited                Pharmaron Manufacturing
   Services (UK) Ltd                             Coventry
                                                             cGMP
                                                       (FDA)
                                          API
     Cramlington                   Coventry


                                    CMC               CDMO
             III                           CMC            CDMO



                             19
(3)

                                                         584.5
                 38.3%                     5.1%                     9.0%
                                                                   24.8%
                                         12.6%
      57.2%                                5.4%
                                                  2022    6   30
                                 3,329




                        CRC                              SSU




      68.4%    2022     6     30                                       970
                               800
       1,997           140           600
                      1,100




                               20
(4)


      95.5                           33.2%                 -19.8%

      84.2%                                    14.5%
          1.3%
                             CDMO


             2022   6   30
                               398           2021   12    31        57

                                                CDMO
                                                                70,000
                    2023                            GMP

                                                                    200L
      2,000L




                               21
                                          CDMO




                                 IND


                                  GLP



                                       ELISpot)

                                 GMP


                                                        GMP


                                                      GMP




  2020
95%
                                   GMP


           non-GLP   GLP                          GLP
     CGT                   GMP

                                                      50      CGT

19                                                2




40                     non-GLP    GLP




                      22
        2021         Pharmaron Biologics UK
        CDMO
                                         QC/QA                    CDMO

                500L SUB                 GMP
                                               50L   500L SUBs




                              GMP                           100
                     QC/QA

                          (CQA)           QC/QA                FDA       EMA
        MHRA                                                 CDMO
        2021                                                    20
                                  CDMO

3.

                                                              585.4
        2021    6    30                     564.8             3.6%

4.

                             0.4941              2021   6  30
            0.4751        4.0%                              0.4939
     2021   6 30                          0.4747        4.0%




                                  23
5.




     (i)
        (ii)
           (iii)




                         2022         2021
                        6 30      6   30




                        585,432   564,837


                         42,609    21,932
                         65,555   106,804
                         32,356    (9,937)


                        725,952   683,636



                         86,154   (32,244)


                        812,106   651,392


                   24
6.

                                                             858.8
          2021   6   30                   13.7              1.6%

                                                             57.0
          2021   6   30                        2,167.9               97.4%




                                                                -1,067.3
                 2021     6   30                          5,005.3
     127.1%


7.

                                        2022     6   30
                          2,736.7
                              858.8

             2022 6 30                                      7,001.7
      2021 12 31           8,643.5
     3,395.3      2021 12 31                   2,982.0
       2022 6 30                                                         2.1
      2021 12 31       2.9




                                   25
8.

                2022     6    30                                 1,073.6
                             489.6                                         584.0


        2022 6 30                                                          45.8%
      2021 12 31             44.0%

9.

        2022 6      30
          412.6               2021     12        31           422.5
                                                      120.3      2021     12    31
                135.3



                2022 6        30
                  111.9                2021       12    31         17.2

10.

                                2022     6       30

11.

        2022    6   30

12.

      (1)       Aesica Pharmaceuticals Limited 100%

            2021 12       Pharmaron UK Limited
            5,500                     47,335.2
            Cramlington Aesica Pharmaceuticals Limited                  Pharmaron
            Manufacturing Services (UK) Ltd 100%                    2022 1
                                  100
                                cGMP
                                  (FDA)                                        (MHRA)

                         CDMO

                                            26
(2)

      2022   2




(3)

      2021   5   27




                      27
(4)                       100%

          2022    3       28
                                                               100%
           2022       4                                    85,242,000

                                                                                        2022
      3    27     2022          4       19        2022     5   6

(5) 2021

          2022    5       31                                                 2021
                               2021            (i)
                 0.45           (ii) 2022 6 13
                                             (10)                                          (5)
                                              794,045,086
           660,028,586 A      134,016,500 H
      397,022,543           330,014,293   A     67,008,250                                     H
                                            2022 5 6
                     2022 5 31

(6)

                                                                           H

           2022       5        31                                            2021

                                    H    250.75                       H   166.42
           H     229.50                                H   152.32           2022    6     14
                     H                                         2021


                                    2022     6    13




                                             28
(7) 2019   A

      2022     1       14
                                               17.85        2019    A
             132,012                     A             2
           2022 5

      2022      5 13              2019    A
               1,112,834                  A

(8) 2022   A

      2022     5       31
      2022     A                        2022   A
                            2022    A                            2022 A
                                                   A             1,548,800    A
                                                                    0.20%
                   A
                                                           25%   25%    25%
    25%          2022         A
    2022   5    6




                                         29
(9)         H

                             76                                      2020               H
                                          H          25%              H                 183,075
                76                                    4
                                                               21,188       H

                                                 H                                            5
                                                          H                              42,300
        H                                                                2022       6    10
                     H
        2020
                                       2022      6    2
      2021                                                          10          5
                  2020


        2022         4   1              H                                                    H
                                                 44                             751,110      H
                2022         5    31             H
        H                                                     131
      7,588,450          H                                                          2021
                                                                                     H

                                              25%     25%     25%    25%




                                            30
C.




     1




         31
(1)




            CADD
                                        GMP


                                  GMP




(2)




                       2018


                           AMS             ADME
      Absorption Systems                 DMPK/ADME
                                 DMPK

(3)                        POC




                                 32
      IND




(4)




            IND




                  CRO




                  33
    (5)                         IND




                                  IND
                 2020
                   ICH             GLP/GCP/GMP
                               2021                          Pharmaron
          Biologics UK                                      GMP
                                           NMPA       FDA   OECD GLP

                                          IND




2


                          20                     11




                         IND            IND




                                 34
                     Cramlington
    Hoddesdon




3




                     (DEL)
                3D




                35
4


                           Boliang LOU
    30
                                 10

    2         15


                        2,800


                                2022   6   30
         15,820




                   36
5



                     2022
    400        90%




          37
2022

A.

     1.




          (1)




                                                         2021
                                         5,661                2026
                                            7,771        2021     2026
                       6.5%           2021
                       5,620               2026                          9,566
                       2021    2026                    11.2%

          (2)




                           2021
                   1,403                   2026                 2,477            2021
                   2026                      12%


                                                                        2021
                                                                   11.9%
                2026                                                     3,424
                                               21.4%



                                          38
a.


                        2021                     CRO
       159                                                   CRO
                                                          46.0%
       2026                                               320
     2021     2026                       15.0%
                      64.2%                 2021
     CRO                                 168
                                     16.3%         2026
                                            512
              24.6%

b.

                          (CDMO)

         2021       CDMO                 637
           2026        CDMO                    1,188
             2021 2026             13.3%
     2021       CDMO                       432
               CMO         10.5%        2026
        CDMO                    1,526
             19.8%

c.


                                          2021
                  500                                 CRO
                                            42.9%         2026
                               797          2021     2026
                9.8%                            47.8%
     2021                                                    316
                                               9.8%
                          2026
              1,003                                    19.4%



                          39
2.




     40
3.          2022

     2022


     (1)


                                               2022




                           2022


                   CDMO




     (2)

                                        2022




                    CDMO

                                       2022

            CDMO




                                  41
 3




(4)



      2022
                         2022


(5)

      2022




             2022




(6)




                    42
     (7)

           2022
                                                     1   Hoddesdon
           Liverpool   Rushden
                                             2
           CGT                   San Diego   Exton
                  3
                                    CDMO




4.

     (1)




                                   43
(2)




(3)




      44
(4)



           FDA    NMPA




(5)




           2015




      45
(6)




(7)




(8)


      CMC   CDMO




            46
(9)




(10)




       47
A.

             H
        4,522.7   2022     6     30
     213.7                                                                     2019   11
     14                                             2022      6     30


                                                                   2022
                                                    2022          6 30
                                                   6 30
                                                                                           (1)




                                                                                    2022
                                                                                  6 30
                         30.0%         1,356.8      1,356.8               –

                                                                                    2022
                                                                                  6 30
                         19.5%             881.9     881.9                –

                                                                                    2022
                                                                                  6 30
                         4.5%              203.5     203.5                –

                                                                                    2022
                                                                                  6 30
                         6.0%              271.4     271.4                –

                                                                                    2022
                                                                                  6 30
                         10.0%             452.3     452.3                –




                                      48
                                           2022
                                2022      6 30
                               6 30
                                                                 (1)




                                                         2022
                                                       6 30
          20.0%        904.5     904.5            –

                                                          2022
                                                       12 31
          15.0%        678.4     464.7      213.7

CRO CMO                                                  2022
                                                       6 30
          15.0%        678.4     678.4            –

                                                         2022
                                                       6 30
          10.0%        452.3     452.3            –

          100%     4,522.7      4,309.0     213.7




                  49
B.

         2021   6   18
                                    300                     1,916
                                           2021 6 8           2021     6      9     2021
     6    11    2021     6   18       2021 6 21
                                            3,776.0               2022        6   30
                                          1,829.2
                                     2021 6 21
                                        2022 6 30

                                                                      2022
                                                        2022         6 30
                                                       6 30




                                                                                      2024
         CMC                                                                       12 31
                                  33.3%    1,258.7       628.7         630.0

                                                                                      2024
                                                                                   12 31
                                  33.3%    1,258.7       400.1         858.6

                                                                                      2024
                                                                                   12 31
                                  13.3%        503.4     242.2         261.2

                                                                                      2023
                                                                                   12 31
                                  10.0%        377.6     298.2          79.4

                                                                                     2022
                                                                                   6 30
                                  10.0%        377.6     377.6               –

                                  100%     3,776.0      1,946.8       1,829.2



                                          50
C.

         2022 6 30                                17,650                    2021   12     31
             14,923



D.

         2022    1       14
                                    17.85                    2019    A                     132,012
             A                 2                                            2022     5

E.

                              Coventry

                 Pharmaron Manufacturing Services (US) LLC
           31.5                    210.6
         Coventry                      2022 7 1
                                                                                   cGMP
                                                                    (FDA)                      (EMA)

                                           Cramlington                      Coventry



          2021       A                                   A

         2022    7       28                       (i)         2021 A
     A                                   70.17                    46.48            2021 A
                                        A                774,200         1,161,300     (ii)
         2021    A                        185                         257,925               A
                                   19                    129,600         A


          2022       A                                   A

       2022 7            28                       2022       A                 379
     2,203,200                            A                                   A                 38.62
                                   2022       A                               A

                     25%      25%        25%      25%




                                                        51
F.




G.


                                              C.2.1




H.

                                   3.21




I.

            (www.hkexnews.hk)   (www.pharmaron.com)
     2022




                   52
2019   A   2019     A

2021   A   2021     A

2021

2021              2021   12       31


2022   A   2022     A

AMS




A                                      1.00




                              H




           53
                                               10               5


              A             H

CMC

CMO


            2004    7       1
                        A
            300759              H
                3759

                       2021 6 18                    (i) 300.0
                   2026
                   40725   (ii)              1,916.0                2026

                    40733

CRO




                    2022        6   13
                                                         A              H
                                    1
            0.45            2021                                    A
                                         H

DMPK/ADME

                     54
                                     A
                            B
                                     H




               H


                            H


                                         2015   9   21

          55.89%

FDA




      H                 H


               1961
                                21       31
               1,700


GLP

GMP




H
                    1.00


H         H

IND
                   55
                                          H




  A                                                    A

  H                                                    H

NMPA


OECD

Pharmaron Biologics   Pharmaron Biologics (UK), Ltd.       Allergan
UK                    Biologics Limited


                               (      )                    ,
                      2021    5 27
                             55.89%




                             56
              2022       6   30

      A               2019 A               2021   A
                    2022 A                        A




                     H




                  2021        6    18     300.0
              2026
              40725

                     2021     6   18          1,916.0
                     2026
                                  40733

          A    H

                              H




SSU




                   57
    %




2022    8   29




*




                 58