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华东医药:2024年第一季度报告(英文版)2024-06-13  

                                                                                          First Quarterly Report 2024 of Huadong Medicine Co., Ltd.



Security code: 000963          Stock abbreviation: Huadong Medicine Announcement                        No.: 2024-041




                                  Huadong Medicine Co., Ltd.
                                  First Quarterly Report 2024
     The Company and all members of the Board of Directors hereby guarantee that the information presented
in this report is authentic, accurate and complete and free of any false records, misleading statements or material
omissions.

Important Declaration:

1. The Board of Directors, Board of Supervisors, directors, supervisors and senior management of Huadong
Medicine Co., Ltd. (hereinafter referred to as the "Company") hereby guarantee that the information presented
in this report is authentic, accurate and complete and free of false records, misleading statements or material
omissions, and shall undertake individual and joint legal liabilities.

2. The Company's legal representative, the officer in charge of accounting, and the head of accounting
department (accounting supervisor) hereby declare that the financial information in this quarterly report is
authentic, accurate and complete.

3. Has the First Quarterly Report been audited?

□Yes No
According to “Stock Listing Rules of the Shenzhen Stock Exchange”, if listed companies have both Chinese
and other language version of public notice, they should ensure the content of both versions are the same. In the
case of discrepancy, the original version in Chinese shall prevail.




                                                                                                                          1
                                                                          First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


I. Key Financial Data

(I) Key accounting data and financial indicators

Does the Company need to retroactively adjust or restate the accounting data of previous years?
□Yes No
                                                                                                 Increase or decrease during the
                                     Current reporting period      Same period last year       current reporting period compared
                                                                                              with the same period of last year (%)
 Operating revenue (RMB)                     10,410,809,128.72           10,114,531,331.77                                    2.93%
 Net profit attributable to
 shareholders of the listed                     862,411,560.96              755,284,976.47                                  14.18%
 company (RMB)
 Net profit attributable to
 shareholders of the listed
 company after deduction of                     838,303,551.41              757,542,618.01                                  10.66%
 non-recurring profits and
 losses (RMB)
 Net cash flow from operating
                                               -484,522,666.13              -246,152,770.16                                -96.84%
 activities (RMB)
 Basic earnings per share
                                                         0.4929                     0.4316                                  14.20%
 (RMB/share)
 Diluted earnings per share
                                                         0.4928                     0.4315                                  14.21%
 (RMB/share)
 Weighted average return on
                                                         4.01%                       3.99%                                   0.02%
 equity
                                                                                              Increase or decrease at the end of the
                                        End of the current
                                                                    End of the last year       current reporting period compared
                                         reporting period
                                                                                                with the end of the last year (%)
 Total assets (RMB)                          34,467,844,280.37           33,509,361,816.98                                     2.86%
 Owners' equity attributable to
 shareholders of listed                      21,955,243,888.90           21,047,609,756.66                                   4.31%
 companies (RMB)



(II) Non-recurring profit and loss items and amounts

Applicable □Not applicable
                                                                                                                       Unit: RMB
                              Item                                Amount during the current reporting period       Description
 Profit and loss on disposal of non-current assets (including
                                                                                                  1,521,275.31
 the write-off of provision for impairment of assets)
 Government grants included in the current profits and
 losses (except those that are closely related to the normal
 business operation of the Company, comply with national
                                                                                               28,822,099.15
 policies and regulations, are enjoyed in accordance with the
 defined criteria, and have a lasting impact on the
 Company's profits and losses)
 Profits and losses from changes in fair value arising from
 financial assets and financial liabilities held by non-
 financial corporations, and profits and losses from the
                                                                                                    -25,364.49
 disposal of financial assets and liabilities, except for the
 effective hedging business related to the normal business
 operation of the Company


                                                                                                                                       2
                                                                            First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


 Other non-operating revenue and expenses other than those
                                                                                                  -1,436,525.67
 mentioned above
 Minus: Amount affected by income tax                                                              4,281,616.36
      Amount affected by minority interests (after tax)                                              491,858.39
 Total                                                                                            24,108,009.55          --
Details of other profit and loss items conforming to the definition of non-recurring profits and losses
□Applicable                         Not applicable
The Company has no other specific circumstances of profit and loss items that meet the definition of non-recurring profits and
losses.
An explanation of the fact that the non-recurring profit and loss items listed in the Explanatory Announcement No.1 on
Information Disclosure by Companies that Offer Securities to the Public - Non-recurring Profits and Losses are defined as
recurring profit and loss items
□Applicable                     Not applicable
The Company did not define the non-recurring profit and loss items listed in the Explanatory Announcement No.1 on Information
Disclosure by Companies that Offer Securities to the Public - Non-recurring Profits and Losses as recurring profit and loss items.


(III) Details and reasons for changes in key accounting data and financial indicators

Applicable □Not applicable
                                 Amount at the Amount at the
                                                              Percentage
Items in the balance sheet        end of the beginning of the
                                                               change
                                   period        period                                           Reasons for changes
                                                                                       Mainly attributable to the decrease in
Notes receivable                        0.00               681.21         -100.00%     commercial acceptance bills receivable
                                                                                       during the current period
                                                                                       Mainly attributable to discounting of bank
Receivables financing               84,325.79           143,436.63        -41.21%
                                                                                       acceptance bills during the current period
                                                                                       Mainly attributable to an increase in
Other accounts receivable           47,383.63             29,113.51        62.75%
                                                                                       provisional payment receivable
                                                                                       Mainly attributable to an increase in loans
Short-term borrowings              108,359.71             82,238.03        31.76%
                                                                                       during the current period
                                                                                       Mainly attributable to a decrease in rental
Advance receipts                       40.52               139.36         -70.92%
                                                                                       received in advance
Employee compensation                                                                  Mainly attributable to remuneration paid
                                    21,539.69             35,914.85       -40.03%
payable                                                                                during the current period
                                                                                       Mainly attributable to the payment of long-
Non-current liabilities due                                                            term payables and long-term borrowings
                                    20,941.37             35,934.26       -41.72%
within one year                                                                        due within one year during the current
                                                                                       period
                                                                                       Mainly attributable to additional leases
Lease liabilities                    8,300.63             5,669.52         46.41%
                                                                                       during the current period
                                                                                       Mainly attributable to the transfer of
Long-term accounts
                                     2,480.53             10,725.12       -76.87%      outstanding acquisition amounts to non-
payable
                                                                                       current liabilities due within one year
Other comprehensive                                                                    Mainly attributable to an increase in
                                       24.80              -4,034.15       100.61%
income                                                                                 foreign currency translation differences
    Items in the profit          Amount in the Amount in the Percentage
                                                                                                   Reasons for changes
        statement                current period previous period change
                                                                        Mainly attributable to an increase in net
Financial expenses                    755.50              2,915.08        -74.08%
                                                                        interest income
                                                                        Mainly attributable to an increase in
Other income                       3,831.17      1,458.25     162.72%
                                                                        revenue-related government grants
Proceeds from disposal of                                               Mainly attributable to an increase in
                                    152.13       -219.99      169.15%
assets                                                                  proceeds from disposal of fixed assets
  Items in the cash flow         Amount in the Amount in the Percentage             Reasons for changes

                                                                                                                                     3
                                                                        First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


        statement               current period previous period change
                                                                               Mainly attributable to the increase in
Net cash flow from
                                  -48,452.27         -24,615.28        -96.84% purchases of goods and cash paid to
operating activities
                                                                               employees
Net cash flows from                                                            Mainly attributable to added investment
                                  -70,737.61         -44,005.53        -60.75%
investing activities                                                           during the current period
Net cash flow from                                                             Mainly attributable to the year-on-year
                                  7,149.63           -84,941.26        108.42%
financing activities                                                           increase in loans during the current period



II. Shareholder Information

(I) Total number of common shareholders, number of preferred shareholders with restored voting rights
and shareholdings of top 10 shareholders

                                                                                                                      Unit: Shares
                                                        Total number of preferred shareholders with restored
 Total number of common shareholders
                                               93,834   voting rights at the end of the reporting period (if                       0
 at the end of the reporting period
                                                        any)
                         Shareholdings of top 10 shareholders (excluding shares lent through refinancing)
                                                                               Number of           Pledged, marked or locked-up
                                           Shareholdi
      Name of              Nature of                       Number of           shares held                     status
                                            ng ratio
     shareholder          shareholder                      shares held       with restricted
                                              (%)                                               Status of shares        Quantity
                                                                             sale conditions
                       Domestic non-
 China Grand
                       state-owned            41.66%      730,938,157.00                0.00 Pledged                  147,070,000.00
 Enterprises, INC.
                       legal person
 Hangzhou Huadong
                       State-owned
 Medicine Group                                16.42%     288,000,000.00               0.00    Not applicable                  0.00
                       legal person
 Co., Ltd.
 Hong Kong
                       Overseas legal
 Securities Clearing                           2.75%        48,286,883.00              0.00    Not applicable                  0.00
                       person
 Company Limited
 China Securities      Domestic non-
 Finance Corporation   state-owned             1.26%        22,186,818.00              0.00    Not applicable                  0.00
 Limited               legal person
 Industrial and
 Commercial Bank
 of China Limited -
 Zhong Ou AMC          Others                  1.15%        20,099,373.00              0.00    Not applicable                  0.00
 Medical and Health
 Hybrid Securities
 Investment Fund
 China Construction
 Bank Corporation -
 E Fund CSI 300
 Medical and Health    Others                  0.72%        12,696,732.00              0.00    Not applicable                  0.00
 Trading Open Index
 Securities
 Investment Fund
 China Construction
 Bank Corporation -
 ICBC Credit Suisse    Others                  0.68%        12,000,000.00              0.00    Not applicable                  0.00
 Frontier Medical
 Equity Securities


                                                                                                                                       4
                                                                          First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


Investment Fund
National Social
Security Fund -         Others                  0.63%        10,983,604.00               0.00   Not applicable                   0.00
Portfolio 110
Industrial and
Commercial Bank
of China Limited -
                        Others                  0.54%         9,494,245.00               0.00   Not applicable                   0.00
Huatai-PB CSI 300
Open-ended Index
Fund
China Life
Insurance (Group)
Company -
Traditional -           Others                  0.50%         8,819,214.00               0.00   Not applicable                   0.00
General Insurance
Products - 005L-
CT001 Shanghai
                              Shareholdings of the top 10 shareholders without restricted sales conditions
                                               Number of shares held without restricted sale                Type of shares
           Name of shareholder
                                                                conditions                        Type of shares          Quantity
                                                                                                       RMB-
China Grand Enterprises, INC.                                                  730,938,157.00      denominated          730,938,157.00
                                                                                                  ordinary share
                                                                                                       RMB-
Hangzhou Huadong Medicine Group
                                                                               288,000,000.00      denominated          288,000,000.00
Co., Ltd.
                                                                                                  ordinary share
                                                                                                       RMB-
Hong Kong Securities Clearing
                                                                                48,286,883.00      denominated           48,286,883.00
Company Limited
                                                                                                  ordinary share
                                                                                                       RMB-
China Securities Finance Corporation
                                                                                22,186,818.00      denominated           22,186,818.00
Limited
                                                                                                  ordinary share
Industrial and Commercial Bank of
                                                                                                       RMB-
China Limited - Zhong Ou AMC
                                                                                20,099,373.00      denominated           20,099,373.00
Medical and Health Hybrid Securities
                                                                                                  ordinary share
Investment Fund
China Construction Bank Corporation -
                                                                                                       RMB-
E Fund CSI 300 Medical and Health
                                                                                12,696,732.00      denominated           12,696,732.00
Trading Open Index Securities
                                                                                                  ordinary share
Investment Fund
China Construction Bank Corporation -                                                                  RMB-
ICBC Credit Suisse Frontier Medical                                             12,000,000.00      denominated           12,000,000.00
Equity Securities Investment Fund                                                                 ordinary share
                                                                                                       RMB-
National Social Security Fund -
                                                                                10,983,604.00      denominated           10,983,604.00
Portfolio 110
                                                                                                  ordinary share
Industrial and Commercial Bank of                                                                      RMB-
China Limited - Huatai-PB CSI 300                                                9,494,245.00      denominated            9,494,245.00
Open-ended Index Fund                                                                             ordinary share
China Life Insurance (Group) Company                                                                   RMB-
- Traditional - General Insurance                                                8,819,214.00      denominated            8,819,214.00
Products - 005L-CT001 Shanghai                                                                    ordinary share
Description of affiliation or concerted action of the      The Company did not know whether there was any relationship among
above shareholders                                         the above shareholders, or whether they were parties acting in concert.
                                                           As of the end of the current reporting period, none of the top 10 common
Description of the participation in securities margin
                                                           shareholders of the Company held shares of the Company through
trading business of top 10 shareholders (if any)
                                                           securities margin trading accounts.


                                                                                                                                         5
                                                                          First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


Participation in the lending of shares through refinancing business of shareholders holding more than 5% of shares, top 10
shareholders and top 10 shareholders holding tradable shares without restricted sale conditions
Applicable □Not applicable

                                                                                                                       Unit: Shares

     Participation in the lending of shares through refinancing business of shareholders holding more than 5% of shares, top 10
                    shareholders and top 10 shareholders holding tradable shares without restricted sale conditions
                    Shares held in ordinary       Shares lent through                                        Shares lent through
                                                                              Shares held in ordinary
                     accounts and credit        refinancing and not yet                                    refinancing and not yet
                                                                            accounts and credit accounts
     Name of       accounts at the beginning         returned at the                                        returned at the end of
                                                                               at the end of the period
   shareholder           of the period          beginning of the period                                           the period
   (full name)        Total       Proportion      Total      Proportion         Total       Proportion       Total       Proportion
                   number of       in share      number       in share       number of       in share       number        in share
                     shares         capital     of shares      capital         shares         capital      of shares       capital
 China Grand
 Enterprises,      730,938,157       41.66%             0        0.00%       730,938,157        41.66%             0          0.00%
 INC.
 Hangzhou
 Huadong
 Medicine          288,000,000       16.42%             0        0.00%       288,000,000        16.42%             0          0.00%
 Group Co.,
 Ltd.
 Hong Kong
 Securities
 Clearing           47,954,932        2.73%             0        0.00%        48,286,883         2.75%             0          0.00%
 Company
 Limited
 China
 Securities
 Finance            22,186,818        1.26%             0        0.00%        22,186,818         1.26%             0          0.00%
 Corporation
 Limited
 Industrial and
 Commercial
 Bank of China
 Limited -
 Zhong Ou
 AMC Medical        31,080,515        1.77%             0        0.00%        20,099,373         1.15%             0          0.00%
 and Health
 Hybrid
 Securities
 Investment
 Fund
 China
 Construction
 Bank
 Corporation -
 E Fund CSI
 300 Medical
                    12,896,932        0.74%      328,500         0.02%        12,696,732         0.72%             0          0.00%
 and Health
 Trading Open
 Index
 Securities
 Investment
 Fund
 China              19,000,000        1.08%             0        0.00%        12,000,000         0.68%             0          0.00%


                                                                                                                                      6
                                                                             First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


 Construction
 Bank
 Corporation -
 ICBC Credit
 Suisse
 Frontier
 Medical
 Equity
 Securities
 Investment
 Fund
 National
 Social
                    13,619,804         0.78%            0            0.00%       10,983,604         0.63%              0          0.00%
 Security Fund
 - Portfolio 110
 Industrial and
 Commercial
 Bank of China
 Limited -
                     6,639,145         0.38%       17,500            0.00%        9,494,245         0.54%          4,600          0.00%
 Huatai-PB
 CSI 300
 Open-ended
 Index Fund
 China Life
 Insurance
 (Group)
 Company -
 Traditional -
                     7,582,314         0.43%            0            0.00%        8,819,214         0.50%              0          0.00%
 General
 Insurance
 Products -
 005L-CT001
 Shanghai
Change in top 10 shareholders and top 10 shareholders holding tradable shares without restricted sale conditions due to
lending/returning of shares through refinancing as compared to the previous period
Applicable □Not applicable

                                                                                                                           Unit: Shares

      Changes in top 10 shareholders and top 10 shareholders holding tradable shares without restricted sale conditions due to
                        lending/returning of shares through refinancing as compared to the previous period
                                                                                              Number of shares held in shareholders'
                              Addition/with         Number of shares lent through
                                                                                               ordinary accounts and credit accounts
                              drawal during    refinancing and not yet returned at the
   Name of shareholder                                                                        and shares lent through refinancing and
                               the current                end of the period
      (full name)                                                                             not yet returned at the end of the period
                                reporting
                                 period        Total number of        Proportion in share     Total number of       Proportion in share
                                                    shares                  capital                shares                 capital
 Industrial and
 Commercial Bank of
 China Limited - Huatai-    Addition                        4,600                   0.00%              9,498,845                  0.54%
 PB CSI 300 Open-
 ended Index Fund
 China Life Insurance
 (Group) Company -
 Traditional - General      Addition                             0                  0.00%              8,819,214                  0.50%
 Insurance Products -
 005L-CT001 Shanghai

                                                                                                                                          7
                                                           First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


 New China Life
 Insurance Co., Ltd. -
 Traditional - General     Withdrawal              0              0.00%             6,920,836               0.39%
 Insurance Products -
 018L-CT001 Shenzhen
 Bank of Shanghai Co.,
 Ltd. - Yinhua CSI
 Innovative
 Pharmaceutical Industry   Withdrawal              0              0.00%             7,318,298               0.42%
 Traded Open-ended
 Index Securities
 Investment Fund


(II) Total number of preferred shareholders and shareholding list of top 10 preferred shareholders of the
Company

□Applicable                    Not applicable



Ⅲ. Other Important Matters

Applicable □Not applicable
      (I) Overview of the Company's overall operations during the reporting period
      In 2024, the reform of the domestic pharmaceutical industry continued to be expanded, which,
coupled with market competition, drove the intensification of the differentiation of pharmaceutical
enterprises. By focusing on the overall strategic planning and annual business objectives, the
Company actively promoted the implementation of various operational management work, and
achieved a good start in the first quarter. During the reporting period, the Company achieved
operating income in the amount of RMB 10.411 billion, up 2.93% year-on-year; net profit
attributable to parent company in the amount of RMB 862 million, up 14.18% year-on-year; net
profit attributable to the parent company after deducting non-recurring profits and losses in the
amount of RMB 838 million, up 10.66% year-on-year; and realized a positive growth in operating
income and net profit compared with the fourth quarter of 2023. After deducting the equity
incentive expenses and the profits and losses of participating and holding R&D institutions, net
profit attributable to shareholders of the listed company upon deduction of non-recurring profits and
losses during the reporting period was amounted to RMB 928 million, representing an increase of
22.45% compared with the net profit attributable to shareholders of the listed company upon
deduction of non-recurring profits and losses in the first quarter of 2023.
      During the reporting period, the overall operation of the core subsidiary Zhongmei Huadong
continued to maintain a stable growth trend, achieved operating income (including CSO business)
in the amount of RMB 3.399 billion, showing a year-on-year increase of 10.53%; and achieved
consolidated net profit attributable to the parent company in the amount of RMB 751 million, with a

                                                                                                                    8
                                                         First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


year-on-year increase of 11.67%.
     During the reporting period, the Company's pharmaceutical business segment achieved an
overall operating income of RMB 6.717 billion, down 1.86% year-on-year, and a net profit of RMB
107 million, up 1.51% year-on-year. The decreasing operating income of the Company's
pharmaceutical business segment was mainly affected by the higher base in the first quarter of
2023. It is expected that the pharmaceutical business segment will return to show positive growth in
the second quarter.
     The Company's aesthetic medicine business continued to maintain a good growth momentum
during the reporting period. Its aesthetic medicine segment realized a consolidated operating
income of RMB 630 million (excluding internal offsets), representing a year-on-year increase of
25.30%. Sinclair UK, a wholly-owned subsidiary, continued to expand the global aesthetic medicine
market, realized a consolidated operating income of approximately RMB 272 million during the
reporting period. Due to fluctuations in demands caused by the impact of the slowdown in global
macro-economic growth, it underwent a year-on-year decline of 4.40%, with the overall income
reaching the operating target for the first quarter. Growth rate is expected to gradually pick up from
the second quarter. Sinclair (Shanghai), a wholly-owned subsidiary engaging in domestic aesthetic
medicine, was actively expanding the domestic market. During the reporting period, it achieved
operating income of RMB 257 million, representing a year-on-year increase of 22.65%, and a
quarter-on-quarter increase of 13.38% compared with the fourth quarter of 2023.
     During the reporting period, the income of the Company's industrial microbiology business
maintained a stable growth, up 23.00% year-on-year. Subsequently, along with the active expansion
of the overseas market, increasing online and offline marketing promotion for the domestic animal
health business and the launching of products of Hubei Magic Health, it is expected that the growth
of industrial microbiology business will accelerate.
     (II) Important R&D progress of the Company during the reporting period
     During the reporting period, the Company accelerated its R&D efforts and continued to
increase its R&D investment. The Company's R&D investment in the pharmaceutical industry
(excluding equity investment) amounted to RMB 588 million during the reporting period, of which,
direct R&D expenditure amounted to RMB 349 million, representing a year-on-year increase of
13.96%. The Company's innovative drugs and biosimilar business ushered in a number of important
milestones. The main progress is described as follows:
     1. The Company's BLA application in China for the recurrent pericarditis indication of
Rilonacept (ARCALYST) for injection, a global innovative product introduced from Kiniksa,
USA, was accepted in March 2024;

                                                                                                                 9
                                                       First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


    2. The Company's Chinese IND application for HDM1005, which is the GLP-1R/GIPR dual-
target, long-acting peptide agonist product independently developed by the Company, intended for
weight management among overweight or obese people and for Type 2 diabetes, was approved in
March 2024. The first subject was enrolled and administered in the phase Ia clinical study in China
in March 2024. In addition, the US IND application of HDM1005 for overweight or obesity
indications was approved in April 2024;
    3. Chinese IND Application for HDM2005, the first ADC program that is independently
developed by the Company and intended for the treatment of advanced solid tumors and
hematological tumors, was submitted and accepted in March 2024;
    4. In March 2024, the Company's U.S. partner announced that ELAHERE (Mirvetuximab
Soravtansine Injection), an ADC drug intended for the treatment of platinum-resistant ovarian
cancer, has been converted from accelerated approval to full approval in the United States. In April
2024, the Company was approved to join the international multi-center PSOC (platinum-sensitive
ovarian cancer) Phase III clinical study, to promote this product for the frontline treatment of
ovarian cancer. It is being developed as maintenance therapy for the treatment of subjects with
recurrent platinum-sensitive, epithelial ovarian, primary peritoneal, or fallopian tube cancers with
positive folate receptor alpha (FRα) in combination with bevacizumab;
    5. The NDA application for Relmapirazin Injection in China, which is an innovative drug used
in conjunction with a glomerular filtration rate dynamic monitoring system, was accepted in
January 2024;
    6. On March 1, 2024, CARsgen's CAR-T product Zevorcabtagene Autoleucel Injection (trade
name: Saikaize, R&D code: CT053), has received notification from the National Medical
Products Administration (NMPA) that it has been granted conditional approval for the treatment of
adult patients with relapsed or refractory multiple myeloma, who have previously progressed after
at least 3 lines of therapy (including a proteasome inhibitor and immunomodulator agent). The
Company was granted the exclusive right to commercialize zevorcabtagene autoleucel in mainland
China, and has set up a dedicated commercialization team. The first prescription was issued on the
day when such product was approved for marketing.
    In addition, the Company's generic drug registration was proceeded as planned. Tacrolimus
Extended-Release Capsules with a specification of 5mg were approved by the NMPA for marketing
in February 2024.
    During the reporting period, the Company continued to promote the registration and
implementation of key aesthetic medicine in China:
    1. The Chinese clinical trial of MaiLi Extreme, the Company's new high-end lidocaine-

                                                                                                             10
                                                            First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


containing sodium hyaluronate for injection, successfully reached the primary study endpoint and
showed good product safety data. The application for registration of this product as a Class III
medical device in China has recently been accepted;
     2. Two innovative botulinum toxin products under development, i.e., ATGC-110 (Type A
botulinum toxin) and YY001 (Type A recombinant botulinum toxin), which were introduced by the
Company in cooperation with South Korea ATGC and Chongqing Claruvis, have made significant
progress respectively: the marketing application of ATGC-110 has been accepted by the Ministry of
Food and Drug Safety (MFDS) of Korea. The declared indication is to improve the moderate to
severe frown lines between eyebrows among adult patients. YY001 has completed the enrollment of
Phase III clinical subjects in China.
     (III) Other important matters
     The Company held the 20th Meeting of the 10th Session of the Board of Directors on February
7, 2024, reviewed and approved the Proposal on Investment in Construction of Bio-Innovation and
Intelligent Manufacturing Center Project, which agreed that Hangzhou Zhongmei Huadong
Pharmaceutical Co., Ltd., a wholly-owned subsidiary of the Company, would invest in construction
of the Bio-Innovation and Intelligent Manufacturing Center Project in accordance with its own
development plan and new product launch plan. The total investment amount of this project is
expected to be RMB 2 billion. This project would be carried out in stages. The investment amount
of Phase I is about RMB 1.188 billion (the final investment amount is subject to the actual
investment expenditure of the project construction) (for details, please refer to the relevant
announcements disclosed by the Company at www.cninfo.com.cn, with the Announcement No.:
2024-006).
     (IV) Registration form of receptions, including research, communication, interview
and other activities during the reporting period
                                                                          Main topics
 Reception     Reception    Receptio    Reception        Reception       discussed and        Basic information
   date         location    n mode      object type       object          information        index of the survey
                                                                            provided
                                                                                      For details, please
                                                                                      refer to the Record
                                                      New China
                                                                                      Sheet of Investor
                            Site                      Asset
                                                                                      Relations Activities
 January 9    Meeting       survey                    Management,        Investor
                                                                                      on January 9 and
 and 10,      room of the   and         Institution   Industrial         communicatio
                                                                                      10, 2024 published
 2024         Company       online                    Securities,        n
                                                                                      by the Company at
                            meeting                   Guotai Junan
                                                                                      https://irm.cninfo.co
                                                      Securities, etc.
                                                                                      m.cn/ and at
                                                                                      www.cninfo.com.cn.
 January 16   Meeting       On-site                   Haitong            Investor     For details, please
                                        Institution
 and 17,      room of the   survey                    Securities,        communicatio refer to the Record

                                                                                                                   11
                                                                          First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


 2024           Company                                         Origin Asset           n                  Sheet of Investor
                                                                Management,                               Relations Activities
                                                                SWS MU                                    on January 16 and
                                                                Fund, etc.                                17, 2024 published
                                                                                                          by the Company at
                                                                                                          https://irm.cninfo.co
                                                                                                          m.cn/ and at
                                                                                                          www.cninfo.com.cn.
                                                                                                          For details, see the
                                                                Soochow                Exchange
                                                                                                          Record Sheet of
                                                                Securities,            Meeting for
                                                                                                          Investor Relations
                                                                Zhong Ou               Launching
                                                                                                          Activities on March
                Meeting                          Institutions   Asset                  New Drug
 March 4,                         Online                                                                  4, 2024, which was
                room of the                      and            Management,            Saikaize of
 2024                             meeting                                                                 published by the
                Company                          individuals    Perseverance           Huadong
                                                                                                          Company at
                                                                Asset                  Medicine and
                                                                                                          https://irm.cninfo.co
                                                                Management,            CARsgen
                                                                                                          m.cn/ and at
                                                                etc.                   Therapeutics
                                                                                                          www.cninfo.com.cn.
                                                                                                          For details, see the
                                                                                                          Record Sheet of
                                                                                       2023 Annual        Investor Relations
                                                                                       Performance        Activities on April
                Meeting                          Institutions   CICC, China
 April 18,                        Online                                               Exchange           18, 2024, which was
                room of the                      and            Securities, TF
 2024                             meeting                                              Meeting of         published by the
                Company                          individuals    Securities, etc.
                                                                                       Huadong            Company at
                                                                                       Medicine           https://irm.cninfo.co
                                                                                                          m.cn/ and at
                                                                                                          www.cninfo.com.cn.



IV. Quarterly Financial Statements

(I) Financial statements

1. Consolidated balance sheet

Prepared by: Huadong Medicine Co., Ltd.
                                                         March 31, 2024
                                                                                                                     Unit: RMB
                                Item                                         Closing balance                Opening balance
 Current assets:
   Monetary funds                                                                  3,563,064,869.46               4,663,378,011.64
   Deposit reservation for balance
   Lendings to banks and other financial institutions
   Trading financial assets
   Derivative financial assets                                                        16,409,129.45                 16,434,493.97
   Notes receivable                                                                                                  6,812,089.97
   Accounts receivable                                                             9,677,692,232.29              7,455,250,690.83
   Receivables financing                                                             843,257,932.30              1,434,366,300.69
   Prepayments                                                                       362,069,336.43                279,207,655.40
   Premium receivable
   Reinsurance accounts receivable
   Reinsurance contract reserve receivable
   Other accounts receivable                                                         473,836,282.59                291,135,104.33
     Including: Interest receivable


                                                                                                                                 12
                                                                 First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


            Dividends receivable                                               2,623,608.84                  2,623,608.84
  Financial assets purchased for resale
  Inventory                                                               4,224,074,951.91              4,290,214,266.03
    Including: Data resources
  Contract assets
  Assets held for sale
  Non-current assets due within one year
  Other current assets                                                       51,878,760.17                 59,881,757.08
Total current assets                                                     19,212,283,494.60             18,496,680,369.94
Non-current assets:
  Loans and advances issued
  Debt investments
  Other debt investments
  Long-term receivables
  Long-term equity investment                                             1,529,526,141.05              1,535,907,809.85
  Investment in other equity instruments                                    565,223,872.68                565,223,872.68
  Other non-current financial assets
  Investment real estate                                                     12,485,783.85                 12,746,181.87
  Fixed assets                                                            4,050,202,967.46              4,140,144,817.51
  Works in progress                                                         927,713,584.81                913,147,212.17
  Productive biological assets
  Oil and gas assets
  Right-of-use assets                                                       139,021,674.64                151,175,007.16
  Intangible assets                                                       2,527,437,482.39              2,333,787,357.62
    Including: Data resources
  Development expenses                                                    1,068,480,143.55                992,532,091.86
    Including: Data resources
  Goodwill                                                                2,596,809,693.91              2,598,696,062.31
  Long-term unamortized expenses                                             19,291,856.38                 20,053,854.34
  Deferred income tax assets                                                187,808,574.44                187,808,574.44
  Other non-current assets                                                1,631,559,010.61              1,561,458,605.23
Total non-current assets                                                 15,255,560,785.77             15,012,681,447.04
Total assets                                                             34,467,844,280.37             33,509,361,816.98
Current liabilities:
  Short-term borrowings                                                   1,083,597,089.07                822,380,292.37
  Borrowings from the central bank
  Borrowings from other banks and other financial institutions
  Trading financial liabilities
  Derivative financial liabilities
  Notes payable                                                           1,437,934,424.82              1,727,420,960.30
  Accounts payable                                                        4,326,094,692.22              4,374,832,979.95
  Advance receipts                                                              405,231.33                  1,393,551.48
  Contract liabilities                                                      170,289,424.40                135,459,275.17
  Expense for financial assets sold for repurchase
  Deposits from customers and interbank
  Receivings from vicariously traded securities
  Receivings from vicariously underwriting securities
  Employee compensation payable                                             215,396,862.69                359,148,474.25
  Taxes and dues payable                                                    547,143,131.41                489,385,055.57
  Other accounts payable                                                  2,910,002,629.17              2,518,621,382.87
     Including: Interests payable
              Dividends payable                                             143,024,219.60                143,024,219.60
  Fees and commissions payable
  Reinsurance accounts payable
  Liabilities held for sale


                                                                                                                       13
                                                                         First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


   Non-current liabilities due within one year                                       209,413,662.46               359,342,623.38
   Other current liabilities                                                          18,040,693.69                14,621,494.85
 Total current liabilities                                                        10,918,317,841.26            10,802,606,090.19
 Non-current liabilities:
   Reinsurance contract reserves
   Long-term borrowings                                                              519,383,524.08               520,759,460.07
   Bonds payable
      Including: Preferred share
                Perpetual bonds
   Lease liabilities                                                                  83,006,313.46                56,695,158.59
   Long-term accounts payable                                                         24,805,289.23               107,251,248.59
   Long-term employee compensation payable
   Estimated liabilities                                                              38,460,444.39                37,184,074.06
   Deferred income                                                                   167,391,739.98               171,056,435.34
   Deferred income tax liabilities                                                   182,493,233.05               184,373,974.04
   Other non-current liabilities                                                      46,192,650.00                47,170,650.00
 Total non-current liabilities                                                     1,061,733,194.19             1,124,491,000.69
 Total liabilities                                                                11,980,051,035.45            11,927,097,090.88
 Owners’ equity:
   Share capital                                                                   1,754,327,548.00              1,754,425,348.00
   Other equity instruments
      Including: Preferred share
                Perpetual bonds
   Capital reserve                                                                 2,448,599,611.00              2,446,313,774.82
   Minus: Treasury stock                                                              82,074,369.07                  84,519,369.07
   Other comprehensive income                                                            247,990.92                 -40,341,544.18
   Special reserves
   Surplus reserves                                                                1,277,779,972.18              1,277,779,972.18
   General risk reserves
   Undistributed profit                                                          16,556,363,135.87            15,693,951,574.91
 Total owners' equity attributable to the parent company                         21,955,243,888.90            21,047,609,756.66
   Minority interests                                                               532,549,356.02               534,654,969.44
 Total owners’ equity                                                           22,487,793,244.92            21,582,264,726.10
 Total liabilities and owners’ equity                                           34,467,844,280.37            33,509,361,816.98
Legal Representative: Lv Liang Officer In Charge of Accounting: Lv Liang        Head of Accounting Department: Qiu Renbo


2. Consolidated profit statement

                                                                                                                     Unit: RMB
                        Item                       Amount incurred in the current period   Amount incurred in the previous period
 I. Total operating revenue                                           10,410,809,128.72                         10,114,531,331.77
    Including: Operating revenue                                      10,410,809,128.72                         10,114,531,331.77
            Interest revenue
            Premiums earned
            Fees and commissions revenue
 II. Total operating costs                                             9,331,357,509.92                          9,111,221,456.77
    Including: Operating costs                                         7,076,397,110.06                          6,790,724,204.77
               Interest expense
               Fees and commissions expenditures
               Surrender value
               Net payments for insurance claims
               Net provision for insurance
 liabilities



                                                                                                                                 14
                                                      First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


          Policy dividend expenditures
          Reinsurance expenses
          Taxes and surcharges                          56,334,556.14                           53,150,033.98
          Selling expenses                           1,574,261,928.29                        1,642,616,610.16
          Management expenses                         335,169,160.39                           330,086,070.32
          R&D expenses                                281,639,751.64                           265,493,695.70
          Financial expenses                             7,555,003.40                           29,150,841.84
             Including: Interest expense                23,050,131.41                           34,466,716.93
                     Interest revenue                   24,409,865.24                           12,491,377.82
  Plus: Other incomes                                   38,311,729.18                           14,582,456.30
          Investment income (loss expressed
                                                       -47,163,448.93                           -61,752,708.66
with “-”)
             Including: Investment income in
                                                       -37,504,466.74                           -52,816,907.73
associates and joint ventures
                     Income from
derecognition of financial assets measured on
the basis of amortization costs
          Exchange earnings (loss expressed
with “-”)
       Net income of exposure hedge (loss
expressed with “-”)
        Income from changes in fair value
                                                           -25,364.49
(loss expressed with “-”)
          Credit impairment loss (loss
expressed with “-”)
          Asset impairment loss (loss expressed
with “-”)
          Proceeds from disposal of assets (loss
                                                         1,521,275.31                            -2,199,859.71
expressed with “-”)
III. Operating profit (loss expressed with “-”)    1,072,095,809.87                          953,939,762.93
   Plus: Non-operating incomes                           1,295,600.39                            1,389,195.74
   Minus: Non-operating expenses                         5,202,610.91                            6,049,187.60
IV. Total profit (total loss expressed with “-”)   1,068,188,799.35                          949,279,771.07
   Minus: Income tax expense                           207,943,278.46                          189,354,280.74
V. Net profit (net loss expressed with “-”)          860,245,520.89                          759,925,490.33
   (I) Classification by continuity of operation
      1. Net profits from continuing operations
                                                      860,245,520.89                           759,925,490.33
(net loss expressed with “-”)
      2. Net profit from discontinued
operations (net loss expressed with “-”)
   (II) Classification by ownership
      1. Net profit attributable to the owners of
                                                      862,411,560.96                           755,284,976.47
the parent company
      2. Minority interest income                       -2,166,040.07                             4,640,513.86
VI. Net of tax of other comprehensive income            40,589,535.10                           -31,351,409.53
   Net of tax of other comprehensive income
attributable to the owner of the parent                 40,589,535.10                           -31,351,409.53
company
      (I) Other comprehensive income that
cannot be reclassified into the profits and                                                        693,671.15
losses
          1. Change from re-measurement of


                                                                                                            15
                                                                       First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


  defined benefit plan
           2. Other comprehensive income that
  cannot be included in the profits and losses
  under the equity method
           3. Changes in fair value of investment
                                                                                                                      693,671.15
  in other equity instruments
           4. Changes in fair value by the
  enterprise’s credit risks
           5. Others
        (II) Other comprehensive income that
                                                                           40,589,535.10                          -32,045,080.68
  can be reclassified into the profits and losses
           1. Other comprehensive income that
  can be transferred to the profit and loss under
  the equity method
           2. Changes in fair value of
  investments in other debt investments
           3. Financial assets reclassified into
  other comprehensive income
           4. Provision for credit impairment of
  other debt investments
           5. Cash flow hedging reserves
           6. Converted difference in foreign
                                                                           40,589,535.10                          -32,045,080.68
  currency financial statements
           7. Others
     Net of tax of other comprehensive income
  attributable to minority shareholders
  VII. Total Comprehensive Income                                         900,835,055.99                          728,574,080.80
     Total comprehensive income attributable to
                                                                          903,001,096.06                          723,933,566.94
  the owner of the parent company
     Total comprehensive income attributable to
                                                                           -2,166,040.07                            4,640,513.86
  minority shareholders
  VIII. Earnings per share:
     (I) Basic earnings per share                                                 0.4929                                  0.4316
     (II) Diluted earnings per share                                              0.4928                                  0.4315
If there is a business combination under common control in this period, the net profit of the combined party before the
combination is RMB 0.00, and the net profit of the combined party in the previous period is RMB 0.00.
Legal Representative: Lv Liang Officer In Charge of Accounting: Lv Liang         Head of Accounting Department: Qiu Renbo


3. Consolidated cash flow statement

                                                                                                                   Unit: RMB
                     Item                      Amount incurred in the current period    Amount incurred in the previous period
 I. Cash flows from operating activities:
    Cash received from selling goods and
                                                                    9,896,088,428.64                           9,958,329,191.55
 providing services
    Net increase in deposits from customers
 as well as banks and other financial
 institutions
   Net increase in borrowings from the
 central bank
    Net increase in borrowings from other
 financial institutions
    Cash received from the original
 insurance contract premium
    Net cash received from reinsurance


                                                                                                                                 16
                                                  First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


business
  Net increase in savings and investment
funds of policyholders
  Cash for interest, fees and commissions
  Net increase in borrowings from banks
and other financial institutions
  Net increase in funds from repurchase
business
  Net cash received from securities trading
agency
  Refund of taxes and fees received                 3,909,537.24                              1,207,680.51
  Other cash received related to business
                                                 179,167,865.43                            166,606,563.49
activities
Subtotal of cash inflow from operating
                                               10,079,165,831.31                        10,126,143,435.55
activities
  Cash paid for purchases of goods and
                                                7,688,555,061.58                         7,268,626,176.06
services
  Net increase in customer loans and
advance payments
  Net increase in deposits with the central
bank and interbank
   Cash for payment of the original
insurance contract
   Net increase in lendings to banks and
other financial institutions
   Cash for interest, handling fees and
commissions
  Cash for payment of dividends on
policies
   Cash paid to and for employees               1,232,560,542.55                           845,672,966.99
   Various taxes and fees paid                    606,028,807.91                           609,699,664.95
   Payment of other cash related to business
                                                1,036,544,085.40                         1,648,297,397.71
activities
Subtotal of cash outflows from operating
                                               10,563,688,497.44                        10,372,296,205.71
activities
Net cash flow from operating activities          -484,522,666.13                          -246,152,770.16
II. Cash flows arising from investment
activities:
   Cash received from investment recovery           1,000,000.00
   Cash received from obtaining investment
                                                    2,000,000.00
income
   Net cash recovered from disposal of
fixed assets, intangible assets and other           2,328,201.94                               149,204.89
long-term assets
   Net cash received from disposal of
subsidiaries and other business units
   Other cash received related to investment
                                                                                            44,313,052.83
activities
Subtotal of cash inflows from investing
                                                    5,328,201.94                            44,462,257.72
activities
  Cash paid for the purchase and
construction of fixed assets, intangible         472,272,778.22                            398,081,956.46
assets and other long-term assets
  Cash paid for investment                         65,861,678.42                            51,794,250.00

                                                                                                        17
                                                          First Quarterly Report 2024 of Huadong Medicine Co., Ltd.


    Net increase in pledged loans
    Net cash paid for acquisition of
                                                           17,006,187.32                            34,641,364.12
 subsidiaries and other business entities
    Payments of other cash related to
                                                         157,563,682.87
 investing activities
 Subtotal of cash outflows from investing
                                                         712,704,326.83                            484,517,570.58
 activities
 Net cash flows from investing activities                -707,376,124.89                          -440,055,312.86
 III. Cash flows arising from financing
 activities:
    Cash received by absorbing investment
       Including: Cash received by
 subsidiaries from minority shareholders'
 investment
    Cash received from obtaining loans                  1,510,044,486.23                           907,116,269.61
    Other cash received related to financing
                                                           62,459,038.61                            59,222,104.05
 activities
 Subtotal of cash inflows from financing
                                                        1,572,503,524.84                           966,338,373.66
 activities
    Cash paid for debt repayment                        1,202,198,901.63                         1,652,722,088.75
    Cash paid to distribute dividends, profits
                                                           36,432,249.03                            64,853,544.08
 or pay interest
       Including: Dividends and profits paid
                                                                                                    13,328,000.00
 by subsidiaries to minority shareholders
    Payment of other cash related to
                                                         262,376,106.69                             98,175,384.50
 financing activities
 Subtotal of cash outflows from financing
                                                        1,501,007,257.35                         1,815,751,017.33
 activities
 Net cash flow from financing activities                   71,496,267.49                          -849,412,643.67
 IV. Impact of exchange rate changes on
                                                           17,392,454.16                              4,528,971.51
 cash and cash equivalents
 V. Net increase in cash and cash equivalents          -1,103,010,069.37                         -1,531,091,755.18
    Plus: Opening balance of cash and cash
                                                        4,208,160,010.91                         3,416,910,702.33
 equivalents
 VI. Closing balance of cash and cash
                                                        3,105,149,941.54                         1,885,818,947.15
 equivalents


(II) Situation of relevant items of financial statements at the beginning of the current
year after the initial implementation of adjustment of the New Accounting Standards in
2024

□Applicable                        Not applicable


(III) Audit report

Has the First Quarterly Report been audited?
□Yes No
The First Quarterly Report of the Company has not been audited.
                                                     Board of Directors of Huadong Medicine Co., Ltd.
                                                                                                April 26, 2024


                                                                                                                18