The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Stock code: 000963 Stock abbreviation: Huadong Medicine Announcement No.: 2021-076 Huadong Medicine Co., Ltd. The Third Quarterly Report 2021 The Company and all members of the Board of Directors hereby guarantee that the information presented in this report is authentic, accurate and complete and free of any false records, misleading statements or material omissions. Important Declaration: 1.The Board of Directors, Board of Supervisors, directors, supervisors and senior management of Huadong Medicine Co., Ltd. (hereinafter referred to as the “Company”) hereby guarantee that the information presented in this report is authentic, accurate and complete and free of any false records, misleading statements or material omissions, and shall undertake individual and joint legal liabilities. 2.The Company’s legal representative and the officer in charge of accounting, and head of accounting department (accounting supervisor) hereby declare and guarantee that the financial statements in this quarter report are authentic, accurate and complete. 3.Has the third quarterly report been audited? □ Yes √ No This report is prepared both in Chinese and English. Should there be any discrepancy between the Chinese and English versions, the Chinese version shall prevail. I. Key financial data (I) Key Accounting Data and Financial Indicators Whether the Company needs to perform retroactive adjustment or restatement of previous accounting data □ Yes √ No Change from the Change of the current From the beginning of the beginning of the year to The current reporting the end of the reporting reporting period over the year to the end of the period period over the same period last year reporting period same period last year Operating revenue (yuan) 8,748,039,460.66 -1.04% 25,927,477,363.27 1.67% Net profit attributable to shareholders of listed 595,038,254.49 -9.88% 1,895,384,579.34 -20.74% companies (yuan) Net profit attributable to 568,039,187.19 -9.00% 1,762,020,074.37 -13.24% shareholders of listed 1 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. companies after deducting non-recurring gains/losses (yuan) Net cash flow from operating activities —— —— 2,105,916,826.72 10.73% (yuan) Basic earnings per share 0.3401 -9.88% 1.0832 -20.74% (yuan/share) Diluted earnings per 0.3401 -9.88% 1.0832 -20.74% share (yuan/share) Weighted average return 3.75% -1.00% 12.28% -5.41% on equity (ROE) End of the current Change of the end of the current reporting period End of last year reporting period over the end of last year Total assets (yuan) 27,687,711,922.81 24,201,348,154.75 14.41% Owners’ equity attributable to 16,250,585,502.88 14,619,821,308.60 11.15% shareholders of listed companies (yuan) Share capital of the Company as of the trading day before disclosure: Share capital of the Company as of the trading day before 1,749,809,548 disclosure (share) Fully diluted earnings per share calculated on the basis of the latest Share capital Dividends paid on preferred shares 0.00 Perpetual bond interest paid (yuan) 0.00 Fully diluted earnings per share calculated on the basis of the 1.0832 latest Share capital (yuan/share) (II)Items and amounts of non-recurring gains/losses √ Applicable □ N/A Amount (from the Amount of the current beginning of the year to Item Note reporting period the end of the reporting period) Gains/losses on disposal of non-current assets (including the written-off part of the accrued assets -356,832.47 -466,951.55 impairment reserve) Government grants included in current gains/losses(excluding those closely related to normal 19,665,596.43 157,973,691.62 operating activities, in line with national policies and measured according to unified national standards) Receivables subject to separate impairment test and 5,388,185.00 reversal of reserve for impairment Other non-operating income or expenditure 2,888,378.89 -2,028,188.08 Less: Amount affected by income tax -2,745,429.38 19,349,865.15 Amount affected by minority interest (after tax) -2,056,495.07 8,152,366.87 Total 26,999,067.30 133,364,504.97 -- Details of other gains/losses items satisfying the definition of non-recurring gains/losses: □ Applicable √ N/A No such case. If the Company recognizes a non-recurring gain/loss listed in the “Interpretative Announcement No. 1 on Information Disclosure Criteria for Public Companies – Non-Recurring Profit/Loss” as a recurring gain/loss, reasons should be specified. □ Applicable √ N/A No such case. 2 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. (III)Changes in key accounting data and financial indicators and their reasons √ Applicable □ N/A Unit: RMB yuan Balance sheet item End of the period Beginning of the Change rate Notes on cause of changes period Accounts receivable 572,080,968.64 828,659,217.25 -30.96% Mainly due to banker’s acceptance discount in financing the current period Accounts receivable 8,147,812,875.63 6,137,675,568.82 32.75% Mainly due to income growth and capital return fluctuation Other receivables 299,688,469.54 87,269,489.82 243.41% Mainly due to the increase of equity transfer accounts receivable and suspense accounts receivable Other current assets 38,039,156.52 85,654,691.58 -55.59% Mainly due to the decrease of input VAT to be deducted at the end of the period Other equity instruments 129,841,291.42 225,453,120.05 -42.41% Mainly due to the transfer of equity instrument investment investment of Ningbo Donghai Bank and the sale of some RAPT shares in the current period Goodwill 2,100,106,651.09 1,469,617,262.10 42.90% Mainly due to the acquisition of Doer Biologics and High Tech in the current period Notes payable 1,381,336,643.84 554,336,058.71 149.19% Mainly due to the increase of bill payment in the current period Contract liabilities 186,487,690.02 94,384,629.77 97.58% Mainly due to the increase of advance drug payments in the current period Non-current liabilities due 23,288,386.11 67,813,886.68 -65.66% Mainly due to the decrease of long-term within one year payables and long-term borrowing due within one year Long-term payables 164,454,591.48 26,812,354.90 513.35% Mainly due to the increase in contingent and deferred consideration resulting from the acquisition of external companies by the subsidiaries Long term loan 287,439,900.00 151,611,367.86 89.59% Mainly due to the increase of subsidiaries’ long-term borrowing Other comprehensive 91,912,418.43 -2,191,069.45 4294.87% Mainly due to the increase in the exchange income differences from translation of foreign currency statements Income statement item Amount of the Amount of the Change rate Notes on cause of changes current period previous period Gains on assets disposal -149,966.61 304,146,257.99 -100.05% Mainly due to the income from asset disposal of Sinclair in the previous period Investment income -60,001,493.40 -20,950,134.64 -186.40% Mainly due to the increase of discount interest and the decrease of net profit of joint ventures in the current period Cash flow statement item Amount of the Amount of the Change rate Notes on cause of changes current period previous period Net cash flows from -1,406,864,147.47 -920,040,870.59 -52.91% Mainly due to the increase of equity investing activities investment in the current period II. Shareholder information (I) Total number of shareholders of common shares and number of shareholders of preferred shares with voting rights restored, as well as information about top 10 shareholders Unit: share Total number of shareholders of Total number of shareholders common shares at the end of the 195,693 of preferred shares whose 0 reporting period voting rights have been restored at the end of the 3 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. reporting period (if any) Information about top 10 shareholders Number of shares Pledged, marked or frozen Shareholding Number of shares Name Nature held with sale ratio held Status Number restrictions Domestic China Grand non-state-owned 41.77% 730,938,157 0 Pledged 238,450,000 Enterprises, Inc. legal person Hangzhou Huadong State-owned legal 16.46% 288,000,000 0 Medicine Group person Co., Ltd. Hong Kong Securities Overseas legal 1.75% 30,641,915 0 Clearing person Company Ltd. Domestic China Securities non-state-owned 1.27% 22,186,818 0 Finance Co., Ltd. legal person National Social Security Fund Others 0.49% 8,500,086 0 Portfolio 503 Domestic natural #Liu Li 0.34% 6,000,000 0 persons Basic Endowment Others 0.27% 4,682,950 0 Insurance Fund Portfolio 15041 Domestic natural #Chen Shaoming 0.21% 3,744,388 0 persons Norges Bank- Overseas legal 0.16% 2,776,229 0 own funds person China Merchants Bank Co., Ltd.- Xingquanheyuan 2-year Holding Others 0.15% 2,609,639 0 Mixed Securities Investment Fund Shares held by the top 10 shareholders of Non- restricted shares Type of shares Name Number of shares held without sale restrictions Type Number RMB common China Grand Enterprises, Inc. 730,938,157 730,938,157 shares Hangzhou Huadong Medicine Group RMB common 288,000,000 288,000,000 Co., Ltd. shares Hong Kong Securities Clearing RMB common 30,641,915 30,641,915 Company Ltd. shares RMB common China Securities Finance Co., Ltd. 22,186,818 22,186,818 shares National Social Security Fund RMB common 8,500,086 8,500,086 Portfolio 503 shares RMB common #Liu Li 6,000,000 6,000,000 shares Basic Endowment Insurance Fund RMB common 4,682,950 4,682,950 Portfolio 15041 shares RMB common #Chen Shaoming 3,744,388 3,744,388 shares 4 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. RMB common Norges Bank-own funds 2,776,229 2,776,229 shares China Merchants Bank Co., Ltd.- Xingquanheyuan 2-year Holding RMB common 2,609,639 2,609,639 Mixed shares Securities Investment Fund Notes on relations and concerted The Company does not know whether the shareholders mentioned above are related parties actions among the shareholders with each other or whether they are acting-in-concert parties with each other. mentioned above At the end of the current reporting period, Liu Li, the sixth shareholder of the Company, held Notes on financing and securities 6,000,000 shares of the Company through financing and securities loan, Chen Shaoming, the loan conducted by top 10 eighth shareholder of the Company, held 3,651,388 shares of the Company through financing shareholders (if any) and securities loan. (II) Total number of shareholders of preferred shares and information about top 10 shareholders of preferred shares □ Applicable √ N/A III. Other important matters √ Applicable □ N/A (I) Overview of operations 1. The Company’s operations during the reporting period In the first three quarters of 2021, the Company deepened the transformation and innovation work. The performance of business indicators in the reporting period decreased year-on-year, but has been significantly improved compared with the first half of the year, and the overall operation maintained a stable and positive trend. The core subsidiary Zhongmei Huadong actively overcame the business and market pressure brought about by the reform of the domestic pharmaceutical industry, accelerated the process of innovation and internationalization, and strengthened the development of out-of-hospital and grass-roots markets. In the first three quarters of 2021, the operating income reached RMB7.804 billion, down 11.4% year on year, and the net profit was RMB1.72 billion, down 11.1% year on year. While the sales volume of main products was increasing, the income from immunity and cardiovascular products co ntinued to increase rapidly. The export of customized high-end bulk drugs (Contract Development and Manufacturing Organization, CDMO) and e-commerce business continued to develop, reflecting the resilience and growth potential of the Company’s pharmaceutical manufacturing business as a whole. In the third quarter, Zhongmei Huadong was affected by product price reduction continuously, with the operating income decreasing by 12.7% year on year but increasing by 2.0% quarter on quarter, and the net profit decreasing by 5.2% year on year (compared with 14.6% year-on-year decline of the first quarter of 2021 and 11.7% year-on-year decline of the second quarter of 2021, indicating the 5 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. trend of narrowing decline and stabilization) but increasing by 14.8% quarter on quarter, which has laid a solid foundation for returning to growth in 2022. In the fourth quarter, the Company will make every effort to manage the operation, strive to achieve growth in the quarter, and endeavor to achieve the operating objectives of the whole year. Ellansé, the core aesthetic medicine product of the Company, has been officially placed on the Chinese mainland market at the end of August. It has been accurately positioned for high-end regeneration market with its unique advantages of “immediate filling, lasting effect and being metabolizable”. Currently, the number of contracted cooperative hospitals for the product exceeds 120, the number of trained and certified doctors exceeds 200, and its sales and promotion was ready. Ellansé has received extensive attention and popularity from the market since its launch, with a stack of orders from aesthetic medicine institutions and good feedback from customers. As of the release date of this report, the Company has received advances of more than RMB100 million for the product, and is expected to beat the annual sales target, and drive the Company’s domestic aesthetic medicine business to achieve new growth in 2022 based on the head start this year. Facing the strong demand in the domestic market, the Company requires Sinclair’s Dutch factory to give priority to the supply in the domestic market, thus shortening the waiting time of customers. At the same time, the Company will strictly select cooperative institutions and constantly increase the training and certification of doctors to provide responsible and high-quality services to customers. Moreover, to meet the demand growth of Ellansé in the global market, in addition to the factory in Utrecht in the Netherlands, Sinclair built a new factory in Almere, Netherlands, to expand its capacity. At present, the new factory is completed and put into use after passing the certification and approval, so as to fully ensure the subsequent supply of Ellansé around the globe. During the reporting period, the Company’s overseas aesthetic medicine business continued to show rapid growth with the relaxation of pandemic containment measures in various countries. The sales of Ellansé, the core product of Sinclair UK, MaiLi series product, a newly-launched high-end hyaluronic acid filler in Europe, Lanluma , a collagen stimulant, and other products continued to outperform the expectation. In the first three quarters of 2021, Sinclair’s operating income (including acquired Spanish company High Tech) was GBP53.06 million (approximately RMB473 million) with a year-on-year increase of 127.4%. Specifically, Sinclair’s own income increased by 79.24%, and its annual income is expected to reach the highest level in history. Driven by good sales in the end market, High Tech received sufficient orders during the year, which has provided a strong guarantee for the rapid growth of annual income. In the first three quarters of 2021, affected by factors such as non-recurring expenses for the acquisition of High Tech’s equities, Sinclair’s net profit in the overall consolidated statement still showed a loss, but its earnings before 6 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. interest, taxes, depreciation and amortization (i.e. EBITDA) was GBP5.06 million (consolidated specifications), the highest EBITDA since the Company completed the buyout of Sinclair in 2018, and also important evidence of the Company’s ability to run the aesthetic medicine business around the globe. Huadong Pharmaceutical Distribution Company has actively optimized the in-hospital market and expanded the out-of-hospital market, and the overall business maintained a stable growth. In the first three quarters of 2021, the Company’s pharmaceutical commerce segment achieved an operating income of RMB17.268 billion with a year-on-year increase of 7.03%. The establishment of product promotion teams has been accelerated, and the number of innovative drugs introduced to sell by proxy during the year has exceeded that in 2020. The third-party logistics business of pharmaceutical commerce continued with rapid growth, with the phased task of the distribution of COVID-19 vaccines in Zhejiang Province being fully completed. The construction of Jinhua logistics center entered the final stage. During the reporting period, the Company was also selected as a key e-commerce platform enterprise in 2021-2022 in Zhejiang Province. The main reason for the difference between year-on-year decrease in the Company’s net profit and the net profit after deducting non-recurring profits and losses in the reporting period is that the Company’s non-recurring profits and losses in the first quarter of 2020 were RMB290 million, including a net income of GBP30.65 million from the transfer of regional product distribution rights by Sinclair to Galderma, which greatly increased the Company’s overall income in the first quarter of 2020. No such matters occurred during the reporting period, and other non-recurring gains and losses totaled RMB133 million in the first three quarters of 2021, resulting in a decrease in the net profit attributable to shareholders of the listed company year on year. 2. Building an R&D ecosystem of the Company and accelerating the process of innovation and internationalization During the reporting period, Zhongmei Huadong and Huadong Medicine Investment Holding (Hong Kong) Co., Ltd. (hereinafter referred to as the “Investment Holding”), wholly-owned subsidiaries of the Company, signed an equity investment agreement and exclusive product license agreement with Ashvattha Therapeutic, Inc. (hereinafter referred to as “Ashvattha”). Investment Holding will subscribe for Series B preferred shares issued by Ashvattha in stages. Meanwhile, Zhongmei Huadong will obtain the exclusive license of Ashvattha’s 8 products under research in 20 Asian countries and regions such as China, Singapore and Malaysia, including the use of Ashvattha’s relevant intellectual property rights for R&D, production and commercialization. Ashvattha is an innovative biopharmaceutical enterprise focusing on the development of hydroxyl dendrimer (HD) therapeutics (HDTs). Based on interdisciplinary transformation research 7 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. of dendrimers that can cross the tissue barrier, its scientific research team connects active pharmaceutical ingredients (API) or imaging agent with HD to form new patented drugs, which can achieve precise treatment by targeting disease cells and have clinical significance and application prospect. Ashvattha applies the technology of nanomedicine and nano materials. Its unique HD platform is the only hydroxyl dendrimer platform capable of producing highly selective drugs in the world. Ashvattha has a reasonable patent portfolio and has the potential to develop a variety of therapeutic drugs. Ashvattha was founded by three scientists, namely, Dr. Kannan Rangaramanujam, the Arnall Patz distinguished professor of ophthalmology and co-director of center for nanomedicine at the Wilmer Eye Institute at Johns Hopkins School of Medicine, Dr. Sujatha Kannan, the Richard J. Traystman Professor and Vice chair of research in Anesthesiology and Critical Care Medicine (ACCM) at Johns Hopkins School of Medicine, and Dr. Jeffrey Cleland, who graduated from Massachusetts Institute of Technology in chemical engineering, worked for Genentech and committed to new drug research and development for more than ten years. The three founders have made achievements in the field of medicine, published a large number of academic articles and owned dozens of invention patents. In addition, Ashvattha also has a team of professional consultants with rich research experience and professional experience. The Company introduced eight products under research from Ashvattha, covering the fields of tumor, metabolic comorbidity, inflammation, etc.. One of the products has entered phase II clinical trial in the United States, and two products will be submitted for IND review in the United States in the first quarter of 2022. This cooperation will further enrich the Company’s innovative product pipeline in the fields of tumor, immunity and endocrinology, and help to improve the Company’s internationalization and scientific research innovation level. In the future, the products will also provide doctors and patients with more precise and scientific diagnosis and treatment and medication options after launching. The Company has invested, held shares in and incubated a number of domestic biotechnology companies with leading technology. For example, it invested in Peg-Bio Biopharm featuring a peptide technology platform, Qyuns Therapeutics, an antibody company focusing on immune diseases, and Nuoling Biomedical Technology featuring ADC linker and coupling technology; it incubated Huida Biotech which has a full line of toxin ingredients used to develop ADC drugs; and it holds stakes in Doer Biologics which focuses on the development of a Polyclonal antibody platform. Through those efforts, the Company has gradually formed its own medical R&D ecosystem. The cooperation with Ashvattha and the introduction of its HD platform technology will become an important part of the Company’s efforts to build an R&D ecosystem and accelerate its 8 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. process of innovation and internationalization. 3. Continuing to enrich product lines and enhancing the competitiveness of diabetes me dicine During the reporting period, the application for marketing authorization regarding the indications for diabetes of the Company’s GLP-1 receptor agonist Liraglutide injection was accepted in September 2021. In addition to the original research company, there is no domestic manufacturer applying for its marketing authorization. Therefore, the Company is expected to become the first enterprise in China to obtain approval for the marketing authorization of Liraglutide’s biosimilar. Furthermore, the Company has carried out phase III clinical research on the indication for weight loss of Liraglutide injection. At present, the enrollment has been completed and a follow-up visit is underway. It is planned to carry out the application for marketing authorization by the end of 2021. In September 2021, the Company granted the exclusive development, production and commercialization rights of the world’s first small-molecule oral GLP-1 receptor agonist TTP273 in Korea to Daewon Pharmaceutical Co., Ltd. of South Korea, which is the Company’s first license-out of innovative products (see the relevant announcement issued by the Company on September 30, 2021). In October, the Company entered into strategic cooperation with Takeda Pharmaceuticals Company Ltd. (hereinafter referred to as “Takeda”) on the commercialization rights of globally innovative DPP-4 inhibitor Nesina (Alogliptin Benzoate Tablets) in China, which has been 9 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. launched in China, further enriching the Company’s diabetes product portfolio, forming synergy with the Company’s existing key products in the field of diabetes, and continuously consolidating and enhancing the competitiveness and leading position of the Company in the field of diabetes medicine in China. The alliance with Takeda also shows the industry’s affirmation of the commercialization ability of the Company in the local market of diabetes medicine. The company has been engaged in the field of diabetes medicine for nearly 20 years, has established a product matrix of core therapeutic targets and mainstream clinical drugs, and already has more than 20 commercialized products and products under research. The diabetes medicine market will continue to be a core area for the Company to expand its layout in the future. The Company will actively accelerate the process of innovation and industrialization through independent research and development, cooperation, equity investment and other diversified modes, continuously provide cutting-edge and advanced drugs in the world, continuously broaden the road of internationalization and make progress towards the world’s leading diabetes medicine manufacturing enterprise. 4. Building a non-invasive + minimally invasive high-end product pipeline to bring a new growth mome ntum to the global aesthetic medicine business During the reporting period, Sinclair cooperated with KiOmed in Belgium to obtain the exclusive license of four globally innovative KiOmedine chitosan products under research and all subsequent chitosan related aesthetic medicine products in the field of aesthetic medicine for skin in other regions of the world except the United States, including the use of KiOmed related intellectual property rights for R&D, production and commercialization. The cooperation is another important strategic measure for global layout of the Company in the field of light aesthetic medicine, will 10 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. further enrich the Company’s innovative filler product pipeline of aesthetic medicine, and realize the full coverage of products in the fields of hyaluronic acid, collagen stimulant, skin booster and so on. KiOmedine is a high-purity natural (non-animal-sourced) medical chitosan derivative developed by KiOmed using its unique patented technology. Compared with hyaluronic acid, KiOmedine is characterized by deep moisturizing, increasing collagen level and anti -aging. In addition, KiOmedine series fillers are expected to further prolong the action time of hyaluronic acid and achieve long-acting filling effect. At present, there is no similar product in the market all over the world. The future launch of the product is expected to change the product landscape of the hyaluronic acid market and will become another potential blockbuster product in the field besides high-end hyaluronic acid MaiLi . The Company introduced a cold-touch cosmetic instrument from R2 Company, Glacial SpaTM (F0, life cosmetology version of a frozen freckle-removing medical device), has obtained marketing approval in Korea and Taiwan of China, and the Non-medical Devices Management Certification from NMPA. It is expected to be officially marketed in China in the fourth quarter of 2021. Cooperation intentions have been reached with some beauty institutions. In addition, the Company has made launching plans in China for the main products on sale overseas and innovative products under research of the wholly-owned subsidiary High Tech in Spain engaged in energy source aesthetic medicine devices, and the relevant registration preparations have been carried out orderly. In particular, the registration of cryolipolysis product Cooltech Define and laser hair removal device Primelase in China will be officially launched before the end of 2021. Safyre, an RF product marketed overseas and suitable for facial rejuvenation and body shaping, is expected to be rolled out in China in the second quarter of 2022. The Company will continue to accelerate the progress of clinical registration and promotion of core aesthetic medicine products at home and abroad, and continuously improve the competitive advantage in the industry by penetrating the global high-end aesthetic medicine market. After three years of rapid development, the Company’s aesthetic medicine business has achieved phased strategic objectives, and developed more than 20 products in the field of non-invasive + minimally invasive aesthetic medicine, with the number and coverage among the front rank of the industry. Of those products, several are expected to be released and sold at home and abroad before 2025, bringing new growth momentum to the Company’s global aesthetic medicine business. 11 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. 填充 肉毒素 埋线 3款KiOmedine MaiLi系列 与Kylane公司合 皮肤动能素 Ellansé 伊妍仕 Lanluma Perfectha 系列 填充剂 美容埋线 (天然<非动物源> Botulinum Toxin 1 (聚左旋乳酸类胶 新型高端含利多 作两款重点研发 注射用聚己内酯微球 原蛋白刺激剂) 双相透明质酸 羧烷基壳聚糖注射 (天然<非动物源> (A型肉毒素) SilhouetteInstalift 卡因透明质酸 产品 剂) 羧烷基壳聚糖和透 明质酸注射剂) 用于皮下层植入 适用于中面部提拉手术 抗衰 唇部、面部 以纠正中到重度 面部和身体填充剂 面部填充 面部填充 面部和身体填充剂 除皱 短暂固定并提拉 改善肤质 填充塑形 鼻唇沟皱纹 脸颊下真皮位置 中国已上市 全球 60 多个国家 研发阶段 美国 FDA 认证 研发阶段 研发阶段 全球 60 多个国家或 欧盟 CE 认证 欧盟 CE 认证 或地区获注册认 预计将于 2026 年 预计 2023 年获得 预计 2024 年后陆 全球 60 多个国家获地区 中国注册上市推进中 地区获注册认证 欧洲已上市 欧洲已上市 证或上市准入 续获得欧盟 CE 获注册认证或上市准入 获得欧盟CE 认证 欧盟 CE认证 或上市准入 欧盟 CE 认证 认证 预计 2024 年在中国上市 皮肤管理 身体塑形 脱毛 酷雪Glacial Spa F1(Glacial Rx) F2(Glacial Ai) Cooltech Cooltech Define Crystile Define2.0 Define3.0 Titania Safyre Primelase Primelase Pro Elysion (F0) 祛除皮肤的良性色素 面部年轻 性病变和低温缓解 皮肤美白提亮 全身美白 身体减脂塑形 身体减脂塑形 身体减脂塑形 紧肤塑形 紧肤塑形 紧肤塑形 化及身体 脱毛 脱毛 脱毛 疼痛、 肿胀、炎症 塑形 和血肿 美国、韩国获批上市 海外研发阶段 海外研发阶段 海外研发阶段 全球 11 个 海外研发阶段 全球 7 个 美国 FDA 510(k)认证 海外研发阶段 欧盟 CE 认证 中国台湾已递交上市 欧盟 CE 认证 预计 2023 年 预计 2024 年 预计 2022年 预计2022年 国家或地 预计 2023 年 国家或地 预计 2024 年 预计 2024 年在 澳洲 TGA 认证 海外已上市 区获 注册 区获注册 申请 2021 年四季度 欧洲已上市 获得欧盟 CE 获得欧盟 CE 获得欧盟 CE 中国上市 认证或上 获得欧盟 CE 在中国上市 美国上市 海外已上市 认证或上 登陆中国市场 认证 认证 认证 市准入 认证 市准入 Note 1: Due to the liquidation of Huadong Ningbo after its operations expire, there is still uncertainty about the subsequent ownership of the interests in the commercialization of botulinum toxin products in China with Jetema of South Korea. 12 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. (II) Research and developme nt and registration During the reporting period, the Company continued to accelerate the R&D work, with a total R&D investment of RMB904 million in the pharmaceutical industry, a year-on-year increase of 8.9%. The clinical study and registration of products under research in the Company’s core areas is advancing in an orderly manner. As of the release of the report, the main R&D and registration progress of the Company’s medicine business is as follows: 1. Diabetes The application for marketing authorization regarding the indication for diabetes of GLP-1 receptor agonist Liraglutide injection was accepted in September 2021. The non-clinical study of Insulin Aspart injection was completed, and it is expected that the application for IND review will be submitted in the first quarter of 2022. HDM1003 (SCO-094) is a dual agonist that targets both GLP-1R and GIPR for the treatment of diseases such as type 2 diabetes, obesity and non-alcoholic steatohepatitis (NASH), jointly developed by the Company and SCOHIA PHARMA, Inc. in Japan. Its Phase I clinical trial is being carried out in the United Kingdom, and the Pre-IND application in China has been submitted. DR10624 is a multiple agonist under research by the holding subsidiary Zhejiang Doer Biologics Corporation that targets GLP-1R/GCGR/FGF21, which can be used for the treatment of diseases such as type 2 diabetes, obesity and NASH. The preparations of its phase I clinical trial overseas and pre-IND application in China in 2022 are underway. 2. Tumor HDM2002 (IMGN853), developed jointly by the Company and ImmunoGen of the United States, is the world’s first ADC drug for FR α-positive ovarian cancer. Its phase III multi-regional clinical trial has been initiated in China, and it is expected that clinical enrollment will be completed in 2022. The clinical enrollment of another key single-arm clinical trial of the drug has been completed in the United States and Europe in the second quarter, and preliminary test results are expected to be obtained by the end of 2021. Mefatinib for the treatment of advanced non-small cell lung cancer is under phase III clinical trial, and the enrollment of the subjects for the phase III clinical trial has been completed. It is expected to carry out application for marketing authorization after the completion of phase III clinical trial in 2022. DR30303 is a product under research of the holding subsidiary Zhejiang Doer Biologics Corporation for the treatment of gastric cancer and pancreatic cancer, and feedback has been received from CDE concerning its application for pre-IND. Its phase I clinical trial will be launched in China in 2022 after IND approval. 3. Autoimmunity The Company introduced HDM3002 (PRV-3279), a bispecific antibody under research of 13 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Provention Bio (USA) for the treatment of systemic lupus erythematosus (SLE) and for preventing or reducing the immunogenicity of gene therapy. At present, pre-IND materials have been submitted in China and feedback has been received. The phase II multi-regional clinical trial of this product will be initiated in China. HDM3001 (QX001S) is a biosimilar of the original drug ustekinumab (Stelara) jointly developed by the Company and its partially-owned company Qyuns Therapeutics and used to treat moderate-to-severe psoriasis of adults. Its phase III clinical trial is underway. 4. Rare diseases Sirolimus Oral Solution produced by the Company has been used clinically to treat a rare pediatric disease tuberous sclerosis complex (TSC) for many years. In view of the urgent clinical needs of children with TSC for approved effective treatment, the Company has submitted a pre-IND application to CDE and plans to carry out a real-world study to support the expansion of the indications. 5. Medicine/medical device HD-NP-102 (MB102, dynamic TGFR monitoring system): A product jointly developed by the Company and Medibeacon, Inc. of the United States for the evaluation of the renal function of healthy people and patients through real-time percutaneous monitoring of glomerular filtration rate. With its accurate diagnosis and risk assessment of early renal injury, the product is of ground-breaking clinical significance. The Company has submitted an application for innovative medical devices to the Center for Medical Device Evaluation of National Medical Products Administration, and the phase III multi-regional clinical trial will be launched by the end of 2021. (III) Other important matters In August 2021, the natural person shareholders of the Company’s holding subsidiary Huadong Ningbo Medicine Co., Ltd. (hereinafter referred to as “Huadong Ningbo”) filed a lawsuit to the People’s Court of Beilun District of Ningbo for an order to dissolve Huadong Ningbo in advance on the grounds that there were serious difficulties in the operation and management of Huadong Ningbo and that the continuing operation of Huadong Ningbo would cause material losses to shareholders. The Company claimed that Huadong Ningbo should enter the legal liquidation after its operation expires on December 31, 2021, but did not agree to dissolve Huadong Ningbo in advance. The case was heard in People’s Court of Beilun District of Ningbo on September 22, 2021, and has not been sentenced yet. Afterward, the Company held meetings with natural person shareholders and management representatives of Huadong Ningbo on relevant matters. The two parties have reached a consensus that Huadong Ningbo has entered the liquidation preparation period, will mainly carry out capital withdrawal before the end of 2021, and will not conduct new business. The parties agree to speed up the preparations for the liquidation of Huadong Ningbo. To 14 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. be responsible to all shareholders and safeguard the interests of all shareholders, the Company will properly carry out the subsequent liquidation of Huadong Ningbo according to law. IV. Quarterly financial statements (I) Financial Statements 1. Consolidated balance sheet Prepared by Huadong Medicine Co., Ltd. Unit: RMB yuan Item September 31, 2021 December 31, 2020 Current assets: Monetary funds 3,366,668,781.24 3,198,080,997.82 Settlement reserve Lending to other banks and other financial institutions Financial assets for trade Derivative financial assets Notes receivable Accounts receivable 8,147,812,875.63 6,137,675,568.82 Accounts receivable financing 572,080,968.64 828,659,217.25 Advance payments 291,583,511.06 250,916,482.07 Premiums receivable Reinsurance accounts receivable Reinsurance contract reserve receivable Other receivables 299,688,469.54 87,269,489.82 Including: Interests receivable 15,972,701.53 Dividends receivable 832,286.37 4,195,666.37 Financial assets purchased for resale Inventories 4,129,417,606.73 4,067,635,254.80 Contract assets Assets held for sale Non-current assets due within one 15 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. year Other current assets 38,039,156.52 85,654,691.58 Total current assets 16,845,291,369.36 14,655,891,702.16 Non-current assets: Loans and prepayments issuance Debt investments Other debt investments Long-term receivables Long-term equity investments 950,889,474.55 850,072,053.02 Other equity instrument 129,841,291.42 225,453,120.05 investments Other non-current financial assets Real estate properties for 17,082,267.95 17,792,735.95 investment Fixed assets 3,106,575,021.33 2,420,366,582.92 Constructions in progress 1,864,058,365.39 2,240,201,926.65 Biological assets for production Oil & gas assets Right-of-use assets 161,568,723.35 Intangible assets 1,707,792,705.74 1,463,242,463.99 Development expenditures Goodwill 2,100,106,651.09 1,469,617,262.10 Long-term unamortized expenses 10,511,051.56 8,811,339.43 Deferred income tax assets 151,508,607.37 137,829,774.40 Other non-current assets 642,486,393.70 712,069,194.08 Total non-current assets 10,842,420,553.45 9,545,456,452.59 Total assets 27,687,711,922.81 24,201,348,154.75 Current liabilities: Short-term borrowing 1,280,558,172.04 1,416,932,884.87 Borrowing from the Central bank Borrowing from other banks and other financial institutions Financial liabilities for trade Derivative financial liabilities Notes payable 1,381,336,643.84 554,336,058.71 16 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Accounts payable 4,292,982,588.65 3,947,044,331.68 Advance receipts 1,906,357.52 951,926.56 Contract liabilities 186,487,690.02 94,384,629.77 Financial assets sold for repurchase Absorbing deposits and due from banks Receipts for buying and selling securities as proxy Receipts for underwriting securities as proxy Employee benefits payable 160,461,686.62 152,106,819.91 Taxes and fees payable 565,343,178.21 571,792,475.80 Other payables 2,084,232,842.01 1,817,529,820.99 Including: Interests payable Dividends payable 224,219.60 224,219.60 Handling fees and commissions payable Reinsurance accounts payable Liabilities held for sale Non-current liabilities due within 23,288,386.11 67,813,886.68 one year Other current liabilities 30,059,800.64 10,786,034.37 Total current liabilities 10,006,657,345.66 8,633,678,869.34 Non-current liabilities: Insurance contract reserve Long-term borrowing 287,439,900.00 151,611,367.86 Bonds payable Including: Preferred shares Perpetual bonds Lease liabilities 148,719,237.87 Long-term payables 164,454,591.48 26,812,354.90 Long-term employee benefits payable Provision 37,410,969.95 39,467,829.23 Deferred gains 83,907,277.33 81,628,032.54 17 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Deferred income tax liabilities 83,108,397.29 88,738,187.41 Other non-current liabilities Total non-current liabilities 805,040,373.92 388,257,771.94 Total liabilities 10,811,697,719.58 9,021,936,641.28 Ownership interest: Share capital 1,749,809,548.00 1,749,809,548.00 Other equity instruments Including: Preferred shares Perpetual bonds Capital reserve 2,158,080,661.07 2,158,080,661.07 Less: Treasury shares Other comprehensive income 91,912,418.43 -2,191,069.45 Special reserve Surplus reserve 863,793,516.20 861,680,578.42 General risk reserve Undistributed profit 11,386,989,359.18 9,852,441,590.56 Total ownership interest attributable to 16,250,585,502.88 14,619,821,308.60 the parent company Minority interest 625,428,700.35 559,590,204.87 Total ownership interest 16,876,014,203.23 15,179,411,513.47 Total liabilities & ownership interest 27,687,711,922.81 24,201,348,154.75 Legal representative: Lv Liang Officer in charge of accounting: Lv Liang Head of accounting department : Qiu Renbo 2. Consolidated income statement from the beginning of the year to the end of the reporting period Unit: RMB yuan Item Amount incurred during the current period Amount incurred during the previous period I. Total operating income 25,927,477,363.27 25,500,876,607.95 Including: Operating income 25,927,477,363.27 25,500,876,607.95 Interests received Premiums earned Handling fees and commissions received 18 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. II. Total operating cost 23,721,020,429.04 22,945,770,445.69 Including: Operating cost 17,820,264,592.12 16,739,900,305.18 Interests paid Handling fees and commissions paid Surrender value Net payment of insurance claims Net appropriation of policy reserve Policy dividends paid Reinsurance expenses Taxes and surcharges 132,071,642.16 148,487,687.03 Selling expenses 4,165,255,628.17 4,575,928,264.87 Administrative expenses 859,932,896.49 775,033,097.55 R&D expenses 727,596,640.52 689,897,925.27 Financial expenses 15,899,029.58 16,523,165.79 Including: Interests paid 59,960,711.55 59,381,737.63 Interests received 64,850,873.74 52,891,384.64 Add: Other gains 157,965,604.53 123,759,645.82 Investment gains (Losses are -60,001,493.40 -20,950,134.64 indicated by “-”) Including: Investment gains -18,970,341.98 -9,025,650.76 from associates and joint ventures Gains from the derecognition of financial assets measured at amortized cost Gains on exchange (Losses are indicated by “-”) Gains on net exposure hedging (Losses are indicated by “-”) Gains on changes in fair value (Losses are indicated by “-”) Credit impairment loss (Losses -38,263,673.24 -29,841,283.63 are indicated by “-”) Assets impairment loss (Losses 3,054,806.20 are indicated by “-”) 19 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Gains on assets disposal -149,966.61 304,146,257.99 (Losses are indicated by “-”) III. Operating profit (Losses are indicated 2,269,062,211.71 2,932,220,647.80 by “-”) Add: Non-operating income 17,439,095.86 16,504,085.99 Less: Non-operating expenditure 19,888,568.89 26,367,259.87 IV. Total profit (Total losses are 2,266,612,738.68 2,922,357,473.92 indicated by “-”) Less: Income tax expenses 324,435,752.43 462,041,510.71 V. Net profit (Net losses are indicated by 1,942,176,986.25 2,460,315,963.21 “-”) (I) Categorized by the continuity of operations 1. Net profit from continued operations (Net deficit is indicated by 1,942,176,986.25 2,460,315,963.21 “-”) 2. Net profit from discontinued operations (Net deficit is indicated by “-”) (II) Categorized by attribution of the ownership 1. Net profit attributable to owners 1,895,384,579.34 2,391,466,604.78 of the parent company 2. Gains/losses of minority 46,792,406.91 68,849,358.43 shareholders VI. Net amount after tax of other 115,596,732.48 21,024,507.92 comprehensive income Net amount after tax of other comprehensive income attributable to 115,596,732.48 21,024,507.92 owners of the parent company (I) Other comprehensive income that 18,270,393.86 5,817,290.26 cannot be reclassified into gains/losses 1. Changes in remeasurement on the defined benefit plan 2. Other comprehensive income that cannot be reclassified into gains/losses under equity method 3. Changes in fair value of 18,270,393.86 5,817,290.26 20 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. other equity instrument investments 4. Changes in fair value of credit risk of the enterprise 5. Others (II) Other comprehensive income to 97,326,338.62 15,207,217.66 be reclassified into gains/losses 1. Other comprehensive income that can be reclassified into gains/losses under equity method 2. Changes in fair value of other debt investments 3. Amount of financial assets reclassified into other comprehensive income 4. Credit impairment reserve of other debt investments 5. Cash flow hedging reserve 6. Exchange differences arise from translation of foreign currency 97,326,338.62 15,207,217.66 financial statements 7. Others Net amount after tax of other comprehensive income attributable to minority shareholders VII. Total comprehensive income 2,057,773,718.73 2,481,340,471.13 Total comprehensive income attributable to owners of the parent 2,010,981,311.82 2,412,491,112.70 company Total comprehensive income 46,792,406.91 68,849,358.43 attributable to minority shareholders VIII. Earnings per share (EPS): (I) Basic EPS 1.0832 1.3667 (II) Diluted EPS 1.0832 1.3667 As for enterprise merger under the same control in the current period, the net profit generated by the merged party before the merger is 0 yuan, and that generated during the previous period is 0 yuan. Legal representative : Lv Liang Officer in charge of accounting: Lv Liang Head of accounting department : Qiu Renbo 21 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. 3. Consolidated cash flow statement from the beginning of the year to the end of the reporting period Unit: RMB yuan Item Amount incurred during the current period Amount incurred during the previous period I. Cash flows from operating activities: Cash from the sale of goods and 27,674,577,148.04 26,358,487,943.05 provision of services Net increase in customer deposits and due from banks Net increase in borrowing from the central bank Net increase in borrowing from other financial institutions Cash from the premium of the original insurance policy Net cash from reinsurance Net increase in deposits and investment of the insured Cash from interests, handling fees and commissions Net increase in borrowing from other banks and other financial institutions Net increase in funds for repurchase Net cash received for buying and selling securities as proxy Tax refund received 11,649,988.97 17,066,804.84 Other cash receipts in relation to 529,610,507.12 862,918,296.18 operating activities Total cash inflows from operating 28,215,837,644.13 27,238,473,044.07 activities Cash payments for goods and 18,596,693,102.88 17,276,216,270.79 services Net increase in customer loans and prepayments Net increase in deposits of central bank and due from banks 22 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Cash for payment of original insurance claims Net increase in lending to other banks and other financial institutions Cash for payment of interests, handling fees and commissions Cash for payment of policy dividends Cash payments to and for 1,822,563,793.72 1,623,091,615.04 employees Payment of taxes and fees 1,531,826,498.86 1,795,768,635.77 Other cash payments in relation to 4,158,837,421.95 4,641,582,165.81 operating activities Total cash outflows for operating 26,109,920,817.41 25,336,658,687.41 activities Net cash flows from operating activities 2,105,916,826.72 1,901,814,356.66 II. Cash flows from investing activities Cash from recovery of investments 20,432,161.82 Cash from investment gains 4,281,616.50 900,000.00 Net cash from disposal of fixed assets, intangible assets and other 2,009,441.20 349,442,817.74 long-term assets Net cash from disposal of subsidiaries and other business units Other cash receipts in relation to 29,602,856.85 investing activities Total cash inflows from investing 56,326,076.37 350,342,817.74 activities Cash payments for purchase and construction of fixed assets, intangible 539,567,188.77 864,848,688.33 assets and other long-term assets Cash payments for investment 120,706,000.00 70,535,000.00 Net increase in pledge loans Net cash paid for acquisition of 776,789,194.67 335,000,000.00 subsidiaries and other business units Other cash payments in relation to 26,127,840.40 investing activities Total cash outflows for investing 1,463,190,223.84 1,270,383,688.33 23 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. activities Net cash flows from investing activities -1,406,864,147.47 -920,040,870.59 III. Cash flows from financing activities: Cash from absorbing investments Including: Cash from absorption of minority shareholders’ investments by subsidiaries Cash from borrowing 1,854,078,657.43 2,044,165,545.94 Other cash receipts in relation to 360,000,000.00 340,000,000.00 financing activities Total cash inflows from financing 2,214,078,657.43 2,384,165,545.94 activities Cash for repayment of debt 1,874,703,029.58 2,161,566,863.78 Cash payments for dividends, 499,317,003.89 612,515,321.94 profits or interests Including: Payment of dividends and profits by subsidiaries to minority 49,000,000.00 shareholders Other cash payments in relation to 365,675,774.15 357,318,045.74 financing activities Total cash outflows for financing 2,739,695,807.62 3,131,400,231.46 activities Net cash flows from financing activities -525,617,150.19 -747,234,685.52 IV. Influence of exchange rate fluctuations on cash and cash -1,383,998.81 4,496,816.65 equivalents V. Net increase in cash and cash 172,051,530.25 239,035,617.20 equivalents Add: Balance of cash and cash equivalents at the beginning of the 3,157,407,073.26 2,231,771,546.50 period VI. Balance of cash and cash 3,329,458,603.51 2,470,807,163.70 equivalents at the end of the period 24 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. (II) Notes on adjustments of financial statements 1、Adjustments to financial statement items at the beginning of the year of the first implementation of the new accounting standards governing leases which have been implemented since 2021 √ Applicable N/A Whether any balance sheet items at the beginning of the year requires adjustment √Yes □ No Consolidated balance sheet Unit: RMB yuan Item December 31, 2020 January 1, 2021 Adjustment Current assets: Cahs and bank balances 3,198,080,997.82 3,198,080,997.82 Settlement reserve Lending to other banks and other financial institutions Financial assets for trade Derivative financial assets Notes receivable Accounts receivable 6,137,675,568.82 6,137,675,568.82 Accounts receivable for financing 828,659,217.25 828,659,217.25 Prepayments 250,916,482.07 238,357,844.74 -12,558,637.33 Premiums receivable Reinsurance accounts receivable Reinsurance contract reserve receivable Other receivables 87,269,489.82 87,269,489.82 Including: Interests receivable Dividends receivable 4,195,666.37 4,195,666.37 Financial assets purchased for resale Inventories 4,067,635,254.80 4,067,635,254.80 Contract assets Assets held for sale Non-current assets due within one year Other current assets 85,654,691.58 85,654,691.58 25 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Total current assets 14,655,891,702.16 14,643,333,064.83 -12,558,637.33 Non-current assets: Loans and prepayments issuance Debt investments Other debt investments Long-term receivables Long-term equity investments 850,072,053.02 850,072,053.02 Other equity instrument investments 225,453,120.05 225,453,120.05 Other non-current financial assets Real estate properties for investment 17,792,735.95 17,792,735.95 Fixed assets 2,420,366,582.92 2,420,366,582.92 Constructions in progress 2,240,201,926.65 2,240,201,926.65 Biological assets for production Oil & gas assets Right-of-use assets 140,149,561.51 140,149,561.51 Intangible assets 1,463,242,463.99 1,463,242,463.99 Development expenditures 1,469,617,262.10 Goodwill 1,469,617,262.10 Long-term unamortized expenses 8,811,339.43 8,811,339.43 Deferred tax assets 137,829,774.40 137,829,774.40 Other non-current assets 712,069,194.08 712,069,194.08 Total non-current assets 9,545,456,452.59 9,685,606,014.10 140,149,561.51 Total assets 24,201,348,154.75 24,328,939,078.93 127,590,924.18 Current liabilities: Short-term borrowing 1,416,932,884.87 1,416,932,884.87 Borrowing from the central bank Borrowing from other banks and other financial institutions Financial liabilities for trade Derivative financial liabilities Notes payable 554,336,058.71 554,336,058.71 Accounts payable 3,947,044,331.68 3,947,044,331.68 Receipts in Advance 951,926.56 951,926.56 Contract liabilities 94,384,629.77 94,384,629.77 26 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Financial assets sold for repurchase Absorbing deposits and due from banks Receipts for buying and selling securities as proxy Receipts for underwriting securities as proxy Payroll payable 152,106,819.91 152,106,819.91 Taxes payable 571,792,475.80 571,792,475.80 Other payables 1,817,529,820.99 1,817,529,820.99 Including: Interests payable Dividends payable 224,219.60 224,219.60 Handling fees and commissions payable Reinsurance accounts payable Liabilities held for sale Non-current liabilities due within one year 67,813,886.68 67,813,886.68 Other current liabilities 10,786,034.37 10,786,034.37 Total current liabilities 8,633,678,869.34 8,633,678,869.34 Non-current liabilities: Insurance policy reserve Long-term borrowing 151,611,367.86 151,611,367.86 Bonds payable Including: Preferred shares Perpetual bonds Lease liabilities 127,590,924.18 127,590,924.18 Long-term payables 26,812,354.90 26,812,354.90 Long-term employee benefits payable Estimated liabilities 39,467,829.23 39,467,829.23 Deferred income 81,628,032.54 81,628,032.54 Deferred tax liabilities 88,738,187.41 88,738,187.41 Other non-current liabilities Total non-current liabilities 388,257,771.94 515,848,696.12 127,590,924.18 Total liabilities 9,021,936,641.28 9,149,527,565.46 127,590,924.18 Owners’ Equity: Share capital 1,749,809,548.00 1,749,809,548.00 Other equity instruments 27 The Third Quarterly Report 2021 of Huadong Medicine Co., Ltd. Including: Preferred shares Perpetual bonds Capital reserves 2,158,080,661.07 2,158,080,661.07 Less: Treasury shares Other comprehensive income -2,191,069.45 -2,191,069.45 Special reserve Surplus reserves 861,680,578.42 861,680,578.42 General risk reserve Retained earnings 9,852,441,590.56 9,852,441,590.56 Total owners’ equity attributable to owner of 14,619,821,308.60 14,619,821,308.60 the Company Minority interest 559,590,204.87 14,619,821,308.60 Total owners’ equity 15,179,411,513.47 15,179,411,513.47 Total liabilities & owners’ equity 24,201,348,154.75 24,328,939,078.93 127,590,924.18 Adjustment description 2、Retrospective adjustments to comparative data of the previous period due to the first implementation of the new accounting standards leases since 2021 □ Applicable √ N/A (III)Audit report Has the third quarterly report been audited? □ Yes √ No The third quarterly report has not been audited. The Board of Directors of Huadong Medicine Co., Ltd. October 27, 2021 28