2017 2017 10 2017 ( ) 1 2017 2,572,420,412.59 2,167,302,956.39 18.69% 2,050,159,210.01 1,924,331,000.45 6.54% 270,136,038.23 0.50% 768,275,347.94 -2.42% 66,347,372.34 -30.88% 203,427,860.96 -34.03% 51,160,766.48 -40.13% 154,036,021.44 -38.72% -- -- 192,905,368.46 -40.46% / 0.17 -37.04% 0.51 -40.70% / 0.17 -37.04% 0.51 -40.70% 3.28% -5.06% 10.20% -19.55% -113,038.47 41,631,408.08 17,278,229.54 -687,250.55 8,716,402.29 1,106.79 49,391,839.52 -- 1 —— 2 2017 1 10 22,512 0 10 19.97% 80,064,000 80,064,000 3,357,300 14.33% 57,456,000 57,456,000 26,711,260 9.61% 38,520,000 38,520,000 BETA PHARMA INC. 7.14% 28,644,840 28,644,840 6.73% 27,000,000 27,000,000 13,500,000 WANG YINXIANG 5.84% 23,425,560 23,425,560 10,000,000 LAV Equity(Hong Kong)Co.,Limited 5.39% 21,600,000 21,600,000 5.30% 21,240,000 21,240,000 Sequoia Capital China 4.26% 17,088,120 17,088,120 GFII(HK)Limited 2.85% 11,412,000 11,412,000 10 1,002,100 1,002,100 1,001,000 1,001,000 616,400 616,400 - 366,518 366,518 360,900 360,900 - 100 286,000 286,000 3 2017 266,500 266,500 250,000 250,000 - 237,800 237,800 - 224,175 224,175 26.7% 680,784 0.17% WANG YINXIANG 5.84% WANG YINXIANG TAN FENLAI WA N G Y I N X I A N G WANG YINXIANG 33.79% 10 66,000 935,000 1,001,000 459,700 156,700 616,400 700 360,200 360,900 10 10 2 10 3 4 2017 2017 2017 27,013.60 0.50% 6,634.74 30.88% 38.36% 48.97% 2017 9 30 2017 1 1 323,690,696.47 153,949,621.60 110.26% 76,962,948.29 38,120,121.87 101.90% 25,496,156.51 1,758,339.95 1350.01% Xcovery Holding Company LLC 3,915,614.46 54,766,966.67 -92.85% 99,050,645.63 74,977,087.93 32.11% 125,000,000.00 980,120,618.90 -87.25% Tyrogenex,Inc. 138,209,075.49 8,100,000.00 1606.28% Xcovery Holding Company 15,818,237.92 135,070,382.42 LLC -88.29% 369,941,902.60 169,488,049.96 118.27% 258,626,479.85 146,818,171.51 76.15% X396 185,161,860.26 8,581,146.20 2057.78% 5 2017 Xcovery Holding Company LLC 542,588,229.59 200,000,000.00 30,771,154.40 47,752,059.86 -35.56% 61,892,321.64 22,791,258.08 171.56% 129,361,978.19 71,338,894.46 81.33% 2017 1-9 2016 1-9 32,209,872.37 23,562,168.21 36.70% 230,712,289.64 158,054,979.74 45.97% 15,073,577.06 4,476,607.20 236.72% 2017 1-9 2016 1-9 192,905,368.46 324,003,418.20 -40.46% -119,160,524.41 -483,191,108.31 -75.34% 99,263,515.45 -39,108,359.72 -353.82% 1 2014 10 31 ZHAOYIN WANG UNITED STATES POSTAL SERVICE STATE OF CONNECTICUT SUPERIOR COURT ZHAOYIN WANG BETA DON ZHANG “2010 6 BETA ZHAOYIN WANG BETA ZHAOYIN WANG 850,000 ( 140,000 ) BETA2% 1% ” ZHAOYIN WANG 1% 2016 10 26 2017 4 6 2016 2017 6 19 ZHAOYIN WANG 6 2017 www.cninfo.com.cn GUOJIAN XIE 2017 08 08 2017-061 www.cninfo.com.cn GMP 2017 09 04 < GMP > 2017-072 1500 www.cninfo.com.cn Tyrogenex Equinox50% 2017 09 25 Equinox Science LLC 50% Tyrogenex 500 2017-077 2016 2017 3 31 2016 2016 12 31 401,000,000 10 1.8 72,180,000.00 7 2017 8 2017 1 2017 09 30 323,690,696.47 153,949,621.60 76,962,948.29 38,120,121.87 25,496,156.51 1,758,339.95 3,915,614.46 54,766,966.67 99,050,645.63 74,977,087.93 125,000,000.00 980,120,618.90 654,116,061.36 1,303,692,756.92 138,209,075.49 8,100,000.00 9 2017 15,818,237.92 135,070,382.42 401,563,260.46 388,691,557.77 369,941,902.60 169,488,049.96 258,626,479.85 146,818,171.51 185,161,860.26 8,581,146.20 542,588,229.59 142,684.60 6,395,305.06 6,718,207.01 1,918,304,351.23 863,610,199.47 2,572,420,412.59 2,167,302,956.39 200,000,000.00 10,000,000.00 10,000,000.00 30,771,154.40 47,752,059.86 87,359.16 43,705,508.60 53,542,138.10 61,892,321.64 22,791,258.08 199,583.34 10 2017 129,361,978.19 71,338,894.46 476,017,905.33 205,424,350.50 29,472,235.17 31,942,762.51 937,696.01 898,371.97 30,409,931.18 32,841,134.48 506,427,836.51 238,265,484.98 401,000,000.00 401,000,000.00 626,999,485.46 626,999,485.46 10,455,801.65 15,875,453.03 111,797,224.63 111,797,224.63 11 2017 899,906,698.27 768,658,837.33 2,050,159,210.01 1,924,331,000.45 15,833,366.07 4,706,470.96 2,065,992,576.08 1,929,037,471.41 2,572,420,412.59 2,167,302,956.39 2 270,347,924.06 135,110,121.16 76,962,948.29 38,120,121.87 4,135,143.15 1,758,339.95 366,274,351.52 155,480,531.31 99,050,645.63 74,977,087.93 125,000,000.00 977,368,619.72 941,771,012.65 1,382,814,821.94 59,588,895.68 8,100,000.00 922,269,447.92 258,948,069.59 399,901,306.95 388,255,132.09 120,642,345.13 57,813,644.46 12 2017 107,635,444.59 70,293,413.21 47,805,808.38 8,581,146.20 102,924.82 6,248,966.31 6,661,568.26 1,664,092,214.96 798,755,898.63 2,605,863,227.61 2,181,570,720.57 200,000,000.00 10,000,000.00 10,000,000.00 21,519,305.79 47,292,816.65 87,359.16 42,896,647.12 52,694,041.51 74,435,775.72 22,528,275.68 199,583.34 115,425,866.71 71,088,894.46 464,564,537.84 203,604,028.30 13 2017 29,472,235.17 31,942,762.51 937,696.01 898,371.97 30,409,931.18 32,841,134.48 494,974,469.02 236,445,162.78 401,000,000.00 401,000,000.00 626,999,485.46 626,999,485.46 111,797,224.63 111,797,224.63 971,092,048.50 805,328,847.70 2,110,888,758.59 1,945,125,557.79 2,605,863,227.61 2,181,570,720.57 3 270,136,038.23 268,783,830.42 270,136,038.23 268,783,830.42 209,710,138.38 167,950,965.14 10,177,373.60 8,096,686.48 14 2017 5,314,961.27 4,794,223.22 105,226,243.40 94,579,850.48 86,953,282.93 60,377,901.69 1,612,713.87 85,063.92 425,563.31 17,239.35 “ ” “ ” 6,719,114.38 871,921.16 -3,218,616.51 “-” “ ” 67,145,014.23 101,704,786.44 11,768,463.05 8,165,929.45 378,665.95 238,911.65 10,281.42 46.41 “ ” 78,534,811.33 109,631,804.24 15,033,931.10 13,864,513.34 “ ” 63,500,880.23 95,767,290.90 66,347,372.34 95,984,995.87 -2,846,492.11 -217,704.97 -7,169,825.08 916,957.08 -7,169,825.08 916,957.08 1. 2. -7,169,825.08 916,957.08 1. 2. 3. 15 2017 4. 5. -7,169,825.08 916,957.08 6. 56,331,055.15 96,684,247.98 59,177,547.26 96,901,952.95 -2,846,492.11 -217,704.97 0.17 0.27 0.17 0.27 4 270,136,038.23 268,783,830.42 10,177,373.60 8,096,686.48 5,314,961.27 4,794,223.22 105,226,243.40 94,579,850.48 63,017,999.44 58,955,596.87 -300,211.90 138,235.11 82,138.31 17,239.35 “ ” “ ” 6,673,439.49 3,665,893.82 “ ” 93,290,973.60 105,867,892.73 11,668,463.05 8,165,929.45 378,665.95 238,911.65 10,281.42 46.41 “ ” 104,580,770.70 113,794,910.53 15,114,631.10 13,864,513.34 “ ” 89,466,139.60 99,930,397.19 16 2017 1. 2. 1. 2. 3. 4. 5. 6. 89,466,139.60 99,930,397.19 0.22 0.28 0.22 0.28 5 768,275,347.94 787,359,705.40 768,275,347.94 787,359,705.40 583,266,204.57 490,509,284.38 32,209,872.37 23,562,168.21 17 2017 15,285,696.56 14,142,298.39 306,344,008.04 293,219,975.74 230,712,289.64 158,054,979.74 -776,233.47 1,453,467.71 -509,428.56 76,394.59 “ ” “ ” 15,073,577.06 4,476,607.20 -9,000,832.73 “-” “ ” 200,082,720.43 301,327,028.22 41,633,666.83 54,294,322.48 3,902.91 802,547.77 1,342,400.12 113,038.47 467,828.14 “ ” 240,913,839.49 354,278,950.58 42,144,035.74 46,618,031.67 “ ” 198,769,803.75 307,660,918.91 203,427,860.96 308,352,258.40 -4,658,057.21 -691,339.49 -5,419,651.38 3,609,036.37 -5,419,651.38 3,609,036.37 1. 2. -5,419,651.38 3,609,036.37 1. 2. 3. 4. 5. -5,419,651.38 3,609,036.37 6. 18 2017 193,350,152.37 311,269,955.28 198,008,209.58 311,961,294.77 -4,658,057.21 -691,339.49 0.51 0.86 0.51 0.86 6 768,275,347.94 787,359,705.40 32,209,872.37 23,562,168.21 15,285,696.56 14,142,298.39 306,344,008.04 293,219,975.74 193,317,807.57 153,442,073.65 -1,349,001.05 1,703,662.20 127,306.44 24,589.59 “ ” “ ” 17,278,229.54 14,120,965.19 “ ” 239,448,076.23 315,385,902.81 41,531,408.08 54,291,958.82 3,902.91 802,547.77 1,342,400.12 113,038.47 467,828.14 “ ” 280,176,936.54 368,335,461.51 42,233,735.74 46,630,982.92 “ ” 237,943,200.80 321,704,478.59 1. 2. 19 2017 1. 2. 3. 4. 5. 6. 237,943,200.80 321,704,478.59 0.59 0.89 0.59 0.89 7 859,911,604.93 908,395,746.50 2,258.75 1,649,887.00 44,058,239.51 73,862,536.24 903,972,103.19 983,908,169.74 88,736,726.82 64,959,274.35 20 2017 193,200,371.62 153,318,344.90 145,031,548.34 176,503,092.01 284,098,087.95 265,124,040.28 711,066,734.73 659,904,751.54 192,905,368.46 324,003,418.20 1,031,645,070.47 986,927,554.09 120,300.00 457,048.91 5,543,756.13 6,000,000.00 1,031,765,370.47 998,928,359.13 421,125,482.72 174,119,467.44 281,369,000.00 1,308,000,000.00 448,431,412.16 1,150,925,894.88 1,482,119,467.44 -119,160,524.41 -483,191,108.31 299,553,500.00 105,000,000.00 404,553,500.00 99,553,500.00 15,000,000.00 75,115,073.05 4,074,959.72 130,621,411.50 20,033,400.00 21 2017 305,289,984.55 39,108,359.72 99,263,515.45 -39,108,359.72 -3,267,284.63 345,425.28 169,741,074.87 -197,950,624.55 153,949,621.60 260,105,801.52 323,690,696.47 62,155,176.97 8 859,731,604.93 908,395,746.50 1,649,887.00 43,279,928.64 53,500,988.03 903,011,533.57 963,546,621.53 72,809,332.92 64,804,929.63 186,392,288.34 151,126,952.76 144,733,816.62 175,907,195.05 277,947,004.76 242,765,568.88 681,882,442.64 634,604,646.32 221,129,090.93 328,941,975.21 1,031,645,070.47 906,794,855.45 120,300.00 1,196,245.04 7,326,109.74 6,000,000.00 1,031,765,370.47 921,317,210.23 207,403,891.80 114,810,036.71 398,517,960.00 1,240,028,150.00 401,484,700.97 1,007,406,552.77 1,354,838,186.71 24,358,817.70 -433,520,976.48 22 2017 200,000,000.00 285,000,000.00 485,000,000.00 15,000,000.00 74,086,784.95 4,074,959.72 521,163,311.50 63,260,000.00 595,250,096.45 82,334,959.72 -110,250,096.45 -82,334,959.72 -9.28 5.69 135,237,802.90 -186,913,955.30 135,110,121.16 231,072,080.53 270,347,924.06 44,158,125.23 23