Joincare Pharmaceutical Group Annual Report 2022 Stock Code: 600380 Stock Short Name: 健康元 JOINCARE PHARMACEUTICAL GROUP INDUSTRY CO., LTD. 2022 Annual Report 1 Joincare Pharmaceutical Group Annual Report 2022 Important Notice I. The Board of Directors (the “Board”), the Board of Supervisors and directors, supervisors and senior management of the Company hereby warrant the truthfulness, accuracy and completeness of the contents of this annual report (the “Report”), and that there are no false representations, misleading statements or material omissions contained in the Report, and severally and jointly accept legal responsibility. II. All directors of the Company attended the Board meeting. III. Grant Thornton (Special General Partnership) issued a standard unqualified audit report for the Company. IV. Mr. Zhu Baoguo (朱保国), the person-in-charge of the Company, and Mr. Qiu Qingfeng (邱庆丰), the person-in-charge of accounting work and the person-in-charge of the accounting department (the head of the accounting department) declare that they hereby warrant the truthfulness, accuracy and completeness of the financial statements contained in the Report. V. Profit distribution plan or plan for conversion of capital reserve to share capital approved by the Board resolution during the Reporting Period Based on the audit conducted by Grant Thornton (Special General Partnership), in 2022, the Parent Company generated net profit of RMB849,731,957.95, 10% of which was contributed to the statutory surplus reserve, namely RMB84,973,195.80, the remainder of which, together with undistributed profits for the last year of RMB1,400,174,178.18 and gain on disposal of other equity investments of RMB80,749,859.60, subtracting cash dividends for the last year of RMB277,557,631.65, is the profits available for distribution to shareholders for the year of RMB1,968,125,168.28. The Company plans to distribute cash dividends for the fiscal year 2022, based on the total number of shares for dividend distribution, which is defined by the total shares of Company, minus the shares in the Share Repurchase Account, on the equity registration date designated by the annual profit distribution plan. The Company plans to distribute cash dividend of RMB1.80 (tax inclusive) for every 10 shares of to all shareholders of the Company, and the remaining undistributed profits will be carried forward to the following year. VI. Risk declaration for the forward-looking statements √Applicable □N/A The Report contains forward-looking statements which involve the future plans, development strategies, etc. of the Company, yet do not constitute substantive undertakings of the Company to investors. Investors should exercise caution prior to making investment decisions. VII. Whether there is non-operating use of funds by the controlling shareholder and their related parties No VIII. Whether there is a violation of the prescribed decision-making procedures to provide external guarantees 2 Joincare Pharmaceutical Group Annual Report 2022 No IX. Whether more than half of directors cannot warrant the truthfulness, accuracy and completeness of the Report disclosed by the Company No X. Significant risk warnings There is no exceptionally significant risk that will have a material impact on the production and operation of the Company during the Reporting Period. In this Report, the Company has elaborated on the risks and countermeasures that the Company may face in the course of production and operation, including industry policy risk, market risk, risk of safety and environmental protection, risk in price and supply of raw materials and R&D risk. For more information, please refer to “Potential risks” part in Chapter 3 Management Discussion and Analysis. XI. Others □Applicable √N/A 3 Joincare Pharmaceutical Group Annual Report 2022 Table of Contents Important Notice.........................................................................................................................2 Chairman's Statement .................................................................................................................5 Financial Highlights .................................................................................................................10 Chapter 1 Definitions ...............................................................................................................12 Chapter 2 Company Profile and Major Financial Indicators ....................................................14 Chapter 3 Management Discussion and Analysis ....................................................................19 Chapter 4 Corporate Governance .............................................................................................78 Chapter 5 Environmental and Social Responsibility ................................................................99 Chapter 6 Major Events .........................................................................................................123 Chapter 7 Changes in Equity and Shareholders .....................................................................141 Chapter 8 Information on Preferred Shares ............................................................................148 Chapter 9 Information on Bonds ............................................................................................149 Chapter 10 Financial Statements ............................................................................................150 The Financial Statements signed and sealed by the person-in-charge of the Company, the person-in-charge of the Company's accounting work and the person-in-charge of the accounting department (the head of the accounting department) List of documents The original document of the auditors’ report sealed by the accounting available for inspection firm and signed and sealed by the certified public accountants The original copies of all documents and announcements of the Company which have been disclosed to the public on the website designated by CSRC (China Securities Regulatory Commission) during the Reporting Period 4 Joincare Pharmaceutical Group Annual Report 2022 Chairman's Statement Dear shareholders, 2022 was a year of both carrying forward and breaking new ground for the implementation of the “14th Five-Year” Plan and a crucial year for deeply promoting the “Healthy China’ initiative, and deepening the reform of the medical and healthcare systems. During this year, the pharmaceutical industry underwent significant structural adjustments and steadily entered the “new normal” of transformation and upgrading with more opportunities than challenges. Under the guidance of the national “14th Five-Year” Plan, a number of major policies and guidelines related to the pharmaceutical industry have been released and the theme of high-quality development has become the focus of the new era. 2022 was the 30th anniversary of the establishment of Joincare. During the 30 years with significant changes in the industry, the Group adhered to the mission of “For the health, For the future” and the vision to “Diligently make high-quality and innovative drugs”, focused on the high-quality development of the principal pharmaceutical business, maintained its strategic focuses, and tactically demonstrated its resilience and potential. Based on the development blueprint outlined in the Report to the 20th National Congress of the CPC, the Group achieved effective qualitative improvement and reasonable quantitative growth in expediting product innovation, achieving technical breakthroughs, expanding industrial chains, enhancing the comprehensive competitiveness, and accelerating the pace of internationalization. With the fortitudinous and steadfast efforts of all staff, the Group recorded sustained and steady performance growth and successfully achieved its annual business goals. In 2022, the Group realized total revenues of RMB17,143 million, representing a year-on-year increase of approximately 7.79%; realized a net profit attributable to shareholders of listed companies of RMB1,503 million, representing a year-on-year increase of approximately 13.10%; and realized a net profit attributable to shareholders of listed companies after deduction of the extraordinary gains and losses of RMB1,419 million, representing a year-on-year increase of approximately RMB194 million or 15.84%. We maintained steady performance growth and strived to create higher returns for our shareholders. Based on the operating results and overall financial position of the Group in 2022, the Board of Directors proposed that we continue to adopt a stable profit distribution scheme in 2022. Specifically, a cash dividend of RMB1.80 (tax inclusive) for every 10 shares will be distributed to all shareholders of the Company, based on the total number of shares (excluding the number of shares repurchased but not cancelled by the Company) on the equity registration date designated by the annual profit distribution plan for 2022. No bonus shares will be distributed and no conversion of capital reserve into share capital will be carried out. The profit distribution scheme for 2022 is yet to be reviewed and approved at the Company’s 2022 Annual General Meeting. In 2022, the Group deeply implemented the dual-drive strategy of developing platforms of both innovative medicines and high-barrier complex formulations, focused on unmet clinical needs and constantly created and developed new drivers and new advantages. In terms of R&D innovation, the Group continuously increased R&D expenditures while constantly refining 5 Joincare Pharmaceutical Group Annual Report 2022 differentiated innovation R&D strategies. It combined “long-term” and “short-term” plans on strategic plannings and pipeline deployments and concentrated on the construction of R&D systems covering the full lifecycle of drugs development and production. We continued to increase our R&D expenditures and boosted efforts in the construction of innovative R&D technology platforms for high-barrier complex formulations, including inhalation formulation, antibody, and sustained-release microspheres for injections. We have achieved remarkable results. In 2022, the R&D of many innovative medicine products and high-barrier complex formulations in the Group’s pipeline made significant progress with 6 products approved for launching, 5 products applied for production and 5 products approved for clinical trials. The birth of each new drug or the initiation of each new therapy represents a process of perception to diseases. In October 2022, Tobramycin Inhalation Solution (妥布霉素吸入溶液), a blockbuster product of the Group, was approved for launching. It is the first inhalation drug for bronchiectasis in the world as well as the first nebulizer inhalation antibiotic launched in China, marking that the situation of “no drugs available” faced by bronchiectasis patients in China will be significantly relieved. Meanwhile, it further validates our strategic correctness and the market leader advantages in the inhalation formulation products market. While adhering to strengthening independent innovation, the Group also pays close attention to domestic and overseas cutting-edge technologies and opportunities. In 2022, Joincare and its subsidiary, Livzon Group, jointly established an industrial investment entity and contributed a total of RMB1 billion to strategically invest in high-quality healthcare industry projects, demonstrating the strength and determination of the Group in boosting industrial innovation through “bringing in investments”, establishing diversified platforms for incubating and introducing R&D and innovation projects, rapidly diversifying core pipeline products of the Company and further bolstering the sustained profitability of the Group. In terms of business scope innovation, we continued to use our existing strength as a “springboard” for new businesses, expanding our business territory at a steady pace. In 2022, the Recombinant SARS-CoV-2 Fusion Protein (CHO Cell) Vaccine “Likang V-01”, jointly developed by the Institute of Biophysics of the Chinese Academy of Sciences and Joincare, was successfully developed and approved to be included for heterologous booster vaccination. Our success in R&D of Likang V-01 relies on our ability of R&D transform R&D achievements in the whole chain from clinical research and production to approval, marketing and terminal promotion; and the launch of Likang V01 represents significant breakthroughs in both the construction of the recombinant protein vaccine platform and the commercialization capability in vaccine market niche. In the end of 2022, we adopted new measures in the expansion of the business scope. Relying on the strategic advantages in “APIs-formulations vertical integration” and the leading position in core pet drugs’ APIs of the two listed companies, Joincare and Livzon Group, we integrated our advantageous resources in the R&D, production, brand promotion, online and offline marketing through all channels in the pet drugs sector, coordinated the operation of animal health care products and further boosted the layout on animal health care formulations. 6 Joincare Pharmaceutical Group Annual Report 2022 In terms of business model innovation, in 2022, the Group continued to strengthen and upgrade the “patient-centered” digital marketing ecosystem, adopted new digital marketing models for respiratory drugs, namely “to empower all links including education, screening, diagnosis, treatment, and medication monitoring, form a closed-loop consisting of doctors, hospitals, patients and pharmaceutical companies, and explore the external huge market of chronic disease management with owned traffic, so as to realize real-time interaction between consumers and brands” to expand to gastroenterological, psychiatric and other advantageous sectors of the Group. In 2022, healthcare products & OTC segment of the Group successfully promoted the iteration and upgrading of “Taita” (太太) and other core classical brands through omni-channel strategy. On one hand, it continuously promoted the reform of the offline team structure, upgraded the distribution channel, integrated the key chain stores and empowered the Company with resources; on the other hand, it continued to improve online self-operated channels such as platforms of Tmall, Jingdong (JD), Douyin e- commerce and WeChat Mall, Leveraging on online quality content platforms, it conveyed the scientifically based healthcare concept, accurately reached target users and empowered the revitalization of time-honored brands. We always adhered to the strategy on the coordinated development of industry and capital operation. With our top-notch intuition, courage and industry standard, while leveraging on the opportunities in the capital market, Joincare has maintained the fast-moving edge in the integration of industry and capital market for three decades. In September 2022, the Global Depository Receipts (GDRs) of Joincare were successfully listed on the SIX Stock Exchange, making us the first domestic bio-pharmaceutical enterprise with GDRs issued and successfully listed in Switzerland. As a result, the two listed companies under the Group jointly set a precedent for being listed on, in total, four exchanges in China, Hong Kong and Switzerland. The Group has been paying close attention to policies and opportunities for the innovative development of the capital market and actively serving the strategic development and business layout of enterprises through the capital market. The successful issuance of GDRs in Switzerland represents a key milestone in the internationalization strategy of Joincare, facilitates the Group’s internalization strategy in expanding businesses overseas, and allows the Company to develop an international horizon, pattern and operating logic to improve international recognition, so as to enhance the overall profitability and comprehensive competitiveness of the Company. We always actively undertake social responsibilities and integrate the ESG concept into all links of the strategy and operation of the Group with practical actions. We proactively focus on the internal regulatory environment and external policy guidance and practice the CSR strategy and social welfare initiatives adapted to our current business situation in combination with China’s 14th Five-Year Plan and the local government’s development plan. As a leader in domestic market niche of inhalation formulations, we shoulder the undertakings of pharmaceutical enterprises to serve the country and people. Following the listing of three inhalation formulation products in the fifth-round national volume-based procurement, including 雾舒, 舒 坦琳,丽雾安 and 特瑞通, a new product, successfully won the bidding in the seventh round of national volume-based procurement in July 2022. We have been implementing the concept of inclusive health through academic works, public welfare actions and the promotion of scientific popularization to increasingly enhance the awareness on the diagnosis, treatment and management 7 Joincare Pharmaceutical Group Annual Report 2022 of chronic diseases and improve the accessibility of drugs. As of the end of 2022, “Respiratory Experts' Views” ( 呼 吸 专 家 说 ), a public welfare patient education platform in the domestic respiratory diseases sector under the Group, which is the first of its kind in the industry, had joined hands with thousands of doctors in popularizing the scientific concept on the prevention of chronic respiratory diseases among millions of followers. It focused on Chronic obstructive pulmonary disease (COPD), bronchiectasis and other respiratory diseases with high morbidity but low awareness and rate of standardized treatment, supporting the “Healthy China 2030” with practical actions. In 2022, the segment of inhalation formulations of Joincare realized revenues of RMB1.174 billion, representing a year-on-year increase of 103.37%. Such figures mean that an increasing number of Chinese people obtain high-quality domestic new drugs at a more affordable price. In 2022, the Recombinant SARS-CoV-2 Fusion Protein (CHO Cell) Vaccine “Likang V-01” under the Group was included into the preferred combinations under the Implementation Plan for Vaccination of Second Booster Dose of COVID-19 Vaccines. During the fight against the COVID- 19 pandemic, the Group contributed the strength of pharmaceutical enterprises in building immunologic barriers for people with underlying diseases, the elderly, people exposed to high risks and other key groups through vaccines with excellent protection and high safety. In addition, the Tocilizumab Solution for Injection (Atvtia) (托珠单抗注射液(安维泰)) was approved for market launch in January 2023 and listed in the Diagnosis and Treatment Protocol for COVID-19 (Trial Version 10) and the Diagnosis and Treatment Protocol for Severe COVID-19 Cases (Trial Version 4), effectively relieving the shortage of drugs for severe COVID-19 patients. The Group has actively responded to national policies and calls for years. In combination with its own industrial advantages, the Group jointly launched the “Access to Public Welfare for Chronic Diseases Prevention and Treatment (普惠慢病防治公益项目)”program, which currently covers 8 provinces and 1 autonomous region. It brought drugs and other materials for patients with chronic diseases in remote areas, alleviated their medical burdens and further improved the accessibility of drugs. In 2022, the Group’s public welfare donations amounted to approximately RMB12.117 million. 2023 is the first year for implementing the spirit of the 20th National Congress of the CPC. Based on the new situation and new stage of the pharmaceutical industry, the Group will anchor in high- quality development, conduct in-depth layout with the focus on the two strategic orientations of innovation and internationalization, and review current opportunities and challenges while continuing to balance aspiration with practicality. Firstly, we will stick to and speed up in R&D innovation and continuously launch products with high quality and accurate efficacy. Secondly, we will boost technological and management innovation and vigorously advance the progress of internationalization. Thirdly, we will bravely try new technologies and models, and implement the digital and intelligent transformation in all links of industrial chains from R&D, production and sales to management, so as to improve the operational efficiency and adapt to the new trends of the pharmaceutical industry and market. The Group will continue to deeply penetrate into the markets of innovative drugs and high-barrier complex formulations, keep an acute insight on market changes, break conventional thinking and path dependence, continuously consolidate the industrial position of the Group in all segments and speed up in promoting the high-quality development of industries. In 1992, Joincare embarked on its journey with a strong sense of purpose and determination. Over 8 Joincare Pharmaceutical Group Annual Report 2022 the past three decades, it has overcome many challenges and navigated through significant changes in the industry. This top integrated pharmaceutical enterprise with revenues of RMB17.1 billion, was not a surf boat but became an aircraft carrier in the domestic field of innovation. It will not only ride through the ups and downs of the industry firmly and confidently, but also attract, match and carry more and more like-minded partners to sail, at full speed, towards the new era for the pharmaceutical industry with a bright future. On behalf of the Board of the Company, I would like to take this opportunity to express my sincere gratitude to all Shareholders, all staff of the Group and business partners for their long-lasting care, companion and support. Chairman: Zhu Baoguo 7 April 2023 9 Joincare Pharmaceutical Group Annual Report 2022 Financial Highlights 10 Joincare Pharmaceutical Group Annual Report 2022 Financial Highlights 11 Joincare Pharmaceutical Group Annual Report 2022 Chapter 1 Definitions I. Definitions In this Report, unless the context otherwise requires, the following expressions shall have the following meanings: Definitions of common terms CSRC Refers to China Securities Regulatory Commission SSE Refers to Shanghai Stock Exchange SZSE Refers to Shenzhen Stock Exchange Baiyeyuan or the Controlling Shenzhen Baiyeyuan Investment Co., Ltd. * (深圳市百业 Refers to Shareholder 源投资有限公司) Company, the Company, Group or Joincare Pharmaceutical Group Industry Co., Ltd.* (健康 Refers to the Group 元药业集团股份有限公司) GMP Refers to Good Manufacturing Practice GSP Refers to Good Supply Practice The certification of the products by European Union, indicating that the product has complied the safety requirements specified in the European Directives. The CE Refers to access condition for a product to enter the EU market is that the product has undergone the appropriate conformity assessment procedures and the declaration of conformity of a manufacturer, with attachment of CE mark Certificate of Suitability to Monograph of European CEP Refers to Pharmacopoeia BE Refers to Bioequivalence BLA Refers to Biologics License Application IND Refers to Investigational New Drug Application R&D Refers to Research and Development TCM Refers to Traditional Chinese Medicine NHSA Refers to National Health Security Administration NMPA Refers to National Medical Products Administration Livzon Pharmaceutical Group Inc.* (丽珠医药集团股份 Livzon Group Refers to 有限公司) Shenzhen Haibin Pharmaceutical Co., Ltd.* (深圳市海滨 Haibin Pharma Refers to 制药有限公司) Joincare Haibin Pharmaceutical Co., Ltd.* (健康元海滨药 Joincare Haibin Refers to 业有限公司) Xinxiang Haibin Pharmaceutical Co., Ltd. * (新乡海滨药 Xinxiang Haibin Refers to 业有限公司) Shenzhen Taitai Pharmaceutical Co., Ltd. * (深圳太太药 Taitai Pharmaceutical Refers to 业有限公司) Shenzhen Taitai Genomics Inc. Co., Ltd. * (深圳太太基因 Taitai Genomics Refers to 工程有限公司) Shenzhen Taitai Biotechnology Co., Ltd. *(深圳太太生物 Taitai Biotechnology Refers to 科技有限公司) Henan Province Joincare Biopharmaceutical Research Joincare Biopharmaceutical Refers to Institute Co., Ltd. *(河南省健康元生物医药研究院有 Research Institute 限公司) Jiaozuo Joincare Bio Technological Co., Ltd.*(焦作健 Jiaozuo Joincare Refers to 康元生物制品有限公司) Joincare Daily-Use & Health Care Co., Ltd. * (健康元日 Joincare Daily-Use Refers to 用保健品有限公司) Topsino Refers to Topsino Industries Limited * (天诚实业有限公司) Shenzhen Fenglei Electric Power Investment Co., Ltd. * Fenglei Electric Power Refers to (深圳市风雷电力投资有限公司) Health Pharmaceutical (China) Co., Ltd. * (健康药业(中国) Health Pharmaceutical Refers to 有限公司) 12 Joincare Pharmaceutical Group Annual Report 2022 Shenzhen Hiyeah Industry Co., Ltd. * ( 深圳市喜悦实业 Hiyeah Industry Refers to 有限公司) Shanghai Frontier Health Pharmaceutical Technology Co., Shanghai Frontier Refers to Ltd. *(上海方予健康医药科技有限公司) Joincare (Guangdong) Special Medicine Food Co., Ltd. Joincare Special Medicine Food Refers to *(健康元(广东)特医食品有限公司) Livzon MABPharm Inc. * (珠海市丽珠单抗生物技术有 Livzon MAB Refers to 限公司) Zhuhai Livzon Diagnostics Inc. * ( 珠海丽珠试剂股份有 Livzon Diagnostics Refers to 限公司) Livzon Group Fuzhou Fuxing Pharmaceutical Co., Fuzhou Fuxing Refers to Ltd.*(丽珠集团福州福兴医药有限公司) Livzon Group Xinbeijiang Pharmaceutical Manufacturing Livzon Xinbeijiang Refers to Inc.*( 丽珠集团新北江制药股份有限公司) Livzon Group (Ningxia) Pharmaceutical Manufacturing Ningxia Pharmaceutical Refers to Co., Ltd.* ( 丽珠集团 ( 宁夏) 制药有限公司) Gutian Fuxing Pharmaceutical Co., Ltd. * ( 古田福兴医 Gutian Fuxing Refers to 药有限公司) Zhuhai FTZ Livzon Hecheng Pharmaceutical Livzon Hecheng Refers to Manufacturing Co., Ltd. * ( 珠海保税区丽珠合成制药有 限公司) Livzon Group Limin Pharmaceutical Manufacturing Livzon Limin Refers to Factory *(丽珠集团利民制药厂) Livzon Group Livzon Pharmaceutical Factory * (丽珠集 Livzon Pharmaceutical Factory Refers to 团丽珠制药厂) Jiaozuo Livzon Hecheng Pharmaceutical Manufacturing Jiaozuo Hecheng Refers to Co., Ltd.* ( 焦作丽珠合成制药有限公司) Shanghai Livzon Pharmaceutical Manufacturing Co., Ltd. Shanghai Livzon Refers to *( 上海丽珠制药有限公司) Sichuan Guangda Pharmaceutical Manufacturing Co., Ltd. Sichuan Guangda Refers to *( 四川光大制药有限公司) Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. *( 焦作金 Jinguan Electric Power Refers to 冠嘉华电力有限公司) Tianjin Tongrentang Group Co., Ltd. * ( 天津同仁堂集团 Tianjin Tongrentang Refers to 股份有限公司) Zhuhai Sanmed Biotech Inc. * ( 珠海圣美生物诊断技术 Sanmed Biotech Refers to 有限公司) Zhuhai Livzon Biotechnology Co., Ltd.*( 珠海市丽珠生 LivzonBio Refers to 物医药科技有限公司) Greenanew Refers to Greenanew (Shanghai) Biotechnology Co., Ltd. COVID-19 Refers to A new coronavirus (SARS-CoV-2) The outbreak of the disease caused by a new coronavirus COVID- 19 pandemic or pandemic Refers to called SARS-CoV-2 Ruihua Certied Public Accountants (Special General Ruihua Certied Public Accountants Refers to Partnership) Grant Thornton Refers to Grant Thornton (Special General Partnership) Reporting Period Refers to From 1 January 2022 to 31 December 2022 End of the Reporting Period Refers to 31 December 2022 Currency or unit Refers to RMB unless otherwise specied 13 Joincare Pharmaceutical Group Annual Report 2022 Chapter 2 Company Profile and Major Financial Indicators I. Company profile Chinese name of the Company 健康元药业集团股份有限公司 Abbreviation of the Chinese name 健康元 English name of the Company Joincare Pharmaceutical Group Industry Co., Ltd. Abbreviation of the English name Joincare Legal representative of the Company Zhu Baoguo(朱保国) II. Contact persons and contact information Board Secretary Representatives of Securities Aairs Name Zhao Fengguang ( 赵凤光 ) Li Hongtao( 李洪涛 ) and Luo Xiao( 罗逍 ) Joincare Pharmaceutical Group Building, No. Joincare Pharmaceutical Group Building, No. 17, Address 17, Langshan Road, North District, Hi-tech Langshan Road, North District, Hi-tech Zone, Zone, Nanshan District, Shenzhen Nanshan District, Shenzhen Telephone 0755-86252656, 0755-86252388 0755-86252656, 0755-86252388 Fax 0755-86252165 0755-86252165 lihongtao@joincare.com E-mail zhaofengguang@joincare.com luoxiao@joincare.com III. Introduction of the Company's basic information Registered Joincare Pharmaceutical Group Building, No. 17, Langshan Road, North District, Hi-tech address Zone, Nanshan District, Shenzhen Registered at B5, Hengfeng Industrial City, Hezhou Community, Huangtian Village, Xin’an Town, Bao’an County on 18 December 1992 Changed its registered address to 4-5/F, Dongpeng Building, Shangmeilin Industrial Area, Futian District, Shenzhen on 25 May 1994 Changed its registered address to 24/F, Block B, Fujian Building, Caitian South Road, Futian District, Shenzhen on 4 July 1995 Changed its registered address to 2 3 / F, Diwang Building, Shun Hing Square, No . 3 3 3 , Historical Shennan East Road, Shenzhen on 20 June 1997 changes in Changed its registered address to Taitai Pharmaceutical Industrial Building, the 5th registered Industrial Area, Nanshan District, Shenzhen on 22 September 2000 address Changed its registered address to 23/F, Diwang Building, Shun Hing Square, No .5002, Shennan East Road, Luohu District, Shenzhen on 4 June 2003 Changed its registered address to Joincare Pharmaceutical Group Building, No. 17, Langshan Road, North District, Hi-tech Zone, Nanshan District, Shenzhen on 29 January 2008 Changed its registered address to Joincare Pharmaceutical Group Building, No. 17, Langshan Road, North District, Hi-tech Zone, Nanshan District, Shenzhen on 27 November 2012 Joincare Pharmaceutical Group Building, No. 17, Langshan Road, North District, Hi-tech Oce address Zone, Nanshan District, Shenzhen Postal code of 518057 Oce address Website www.joincare.com E-mail joincare@joincare.com IV. Information disclosure and place for inspection 14 Joincare Pharmaceutical Group Annual Report 2022 Designated media and website for disclosing China Securities Journal, Securities Times, Securities Daily, and annual report Shanghai Securities News Stock exchange website for disclosing annual www.sse.com.cn report The place for inspection of annual report Oce address of the Company V. Company stock profile Company Stock Profile Stock abbreviation prior to Class of stock Listed on Stock Abbreviation Stock code change A Share Shanghai Stock Exchange 健康元 600380 太太药业, S健康元 Joincare Pharmaceutical GDR SIX Swiss Exchange JCARE / Group Industry Co., Ltd. VI. Other relevant information Name Grant Thornton (Special General Partnership) 5th Floor, Scitech Palace, 22 Jianguomen Wai Avenue, Accounting firm appointed Oce address Chaoyang District, Beijing by the Company (domestic) Name of the signing Wang Yuan (王远) and Wang Qilai (王其来) accountants Name Minsheng Securities Co., Ltd. 17th Floor, Block D, Minsheng Financial Centre, 28 Oce address Sponsor appointed for Jianguomen Nei Avenue, Dongcheng District, Beijing performing the duty of representatives continuous supervisory signing the Yu Chunyu (于春宇) and Ma Chujin (马初进) responsibilities during the report Reporting Period Period of continuous From 24 October 2018 to 31 December 2019 supervision Note: According to Article 29 of “Measures for the Administration of the Sponsorship Business for the Offering and Listing of Securities”, for offering of new stocks or convertible corporate bonds by a company listed on the main board, the period of continuous supervision and guidance shall be the remaining time of the current year of the listing of securities and the following one full accounting year. As the Company issued shares to the public by allotment on 24 October 2018, the period of continuous supervision should start from the completion of this issuance and end on 31 December 2 01 9 . Furthermore, according to “Article 13 of the Guidelines of Shanghai Stock Exchange for Self-Regulation Rules for Listed Companies No. 1 1 - Continuous Supervision”, the sponsor shall continue to perform the obligations of continuous supervision if the funds raised have not been fully utilized upon the expiration of the continuous supervision period. During the Reporting Period, funds raised in this issuance have not yet been fully utilized, so the sponsor, Minsheng Securities, shall continue to perform its continuous supervision obligations in respect of the deposit and utilization of the funds raised. VII. Major accounting data and financial indicators in the last three years (1) Major accounting data Unit: Yuan Currency: RMB YoY Change Major accounting data 2022 2021 2020 (%) Revenues 17,142,753,068.82 15,903,688,266.59 7.79 13,521,605,768.20 Net prot attributable to shareholders of the listed 1,502,595,840.48 1,328,499,432.05 13.10 1,120,439,799.25 company 15 Joincare Pharmaceutical Group Annual Report 2022 Net prot attributable to shareholders of the listed company after deduction of 1,419,050,912.26 1,224,997,371.57 15.84 966,680,220.14 extraordinary gains and losses Net cash ow from 3,977,705,139.29 2,563,089,045.24 55.19 3,024,999,592.24 operating activities Increase or decrease at the end of the End of 2022 End of 2021 period over End of 2020 the same period of last year(%) Net assets attributable to shareholders of the listed 13,121,820,410.55 11,820,293,656.69 11.01 11,096,125,890.51 company Total assets 35,729,253,651.41 31,103,900,389.29 14.87 28,156,977,599.07 (2) Major financial indicators YoY Change Major nancial indicators 2022 2021 2020 (%) Basic earnings per share (RMB/share) 0.7933 0.6864 15.57 0.5753 Diluted earnings per share (RMB/share) 0.7921 0.6858 15.50 0.5728 Basic earnings per share after deduction of extraordinary gains and losses 0.7492 0.6329 18.38 0.4964 (RMB/share) Increased by 0.73 Weighted average return on net assets (%) 12.23 11.50 10.41 percentage points Weighted average return on net assets Increased by 0.95 after deduction of extraordinary gains and 11.55 10.60 8.98 percentage points losses (%) Statement on major accounting data and nancial indicators within three years before the End of the Reporting Period √Applicable □N/A The net cash flow from operating activities was RMB3,978 million, representing a year-on-year increase of 55.19%, mainly due to the combined effect of an increase in sales receipts and a decrease in payment of marketing expenses during the Reporting Period. VIII. Differences in accounting data under domestic and foreign accounting standards (1) Differences in net profit and net assets attributable to shareholders of the listed company disclosed in the financial statements according to international accounting standards (IFRS) and Chinese accounting standards (Chinese GAAP) □ Applicable √ N/A (2) Differences in net profit and net assets attributable to shareholders of the listed company disclosed in the financial statements according to foreign accounting standards and Chinese accounting standards □ Applicable √ N/A (3) Explanations on differences under domestic and foreign accounting standards: □ Applicable √ N/A IX. Major financial indicators in 2022 by quarter 16 Joincare Pharmaceutical Group Annual Report 2022 Unit: Yuan Currency: RMB 1st quarter 2nd quarter 3rd quarter 4th quarter (Jan. - Mar.) (Apr.- Jun.) (Jul. - Sept.) (Oct. - Dec.) Revenues 4,657,343,538.89 3,907,601,746.66 4,447,021,452.61 4,130,786,330.66 Net prot attributable to shareholders of the listed 460,537,813.53 340,730,705.97 325,293,433.73 376,033,887.25 company Net profit attributable to Shareholders of the listed company after deducting 457,193,702.95 346,800,729.08 312,360,089.27 302,696,390.96 the extraordinary gains or losses Net cash flow from 871,904,476.98 1,031,048,747.81 706,039,308.18 1,368,712,606.32 operating activities Statement on differences between quarterly data and the data disclosed in previous periodic reports □Applicable √N/A X. Items and amounts of extraordinary gains and losses √Applicable □N/A Unit: Yuan Currency: RMB Item of extraordinary gains and losses 2022 2021 2020 Gain or loss on disposal of non-current -705,357.30 14,492,047.24 102,634,566.25 assets Government grants recognized in profit or loss for the current period (excluding government grants that are closely related to the business of the Company and are 286,842,932.33 245,335,140.69 246,707,925.30 provided in fixed amount or quantity continuously according to the applicable polices and standards of the country) Profit or loss on debt restructuring 0.00 0.00 -298,617.11 Gains and losses on fair value changes incurred from financial assets held for trading, derivative financial assets, financial liabilities held for trading and derivative financial liabilities, and investment income on disposal of financial -109,887,696.11 8,110,644.25 48,458,672.96 assets held for trading, derivative financial assets, financial liabilities held for trading, derivative financial liabilities and other debt investments, except for effective hedging activities related to the ordinary operating business of the Company Reversal of impairment loss on accounts receivable and contract assets tested for 158,470.77 1,013,650.67 0.00 impairment individually Other non-operating income and expenses -23,830,838.49 -30,737,442.83 -22,794,516.25 apart from the above items Less: Effect of income tax 31,919,034.26 39,580,260.30 51,541,134.41 Effect of minority equity (after tax) 37,113,548.72 95,131,719.24 169,407,317.63 Total 83,544,928.22 103,502,060.48 153,759,579.11 Explanations for the Company’s extraordinary gain or loss items as defined in the ‘“Explanatory Announcement No.1 for Public Company Information Disclosures – Extraordinary Gains or Losses’”, and the extraordinary gain or loss items as illustrated in the ‘“Explanatory Announcement No.1 for Public Company Information Disclosures – Extraordinary Gains or Losses’” which has been defined as its recurring gain or loss items. □ Applicable √ N/A 17 Joincare Pharmaceutical Group Annual Report 2022 XI. Items measured at fair value √ Applicable □ N/A Unit: Yuan Currency: RMB Change for the Effect on profits & Item Beginning balance Ending balance period losses for the period Financial assets 184,638,344.31 109,015,664.98 -75,622,679.33 -113,211,242.08 held for trading Other equity instrument 1,408,882,377.42 1,193,958,879.05 -214,923,498.37 18,713,637.23 investments Financial liabilities 143,302.24 755,634.43 612,332.19 -612,332.19 held for trading Total 1,593,664,023.97 1,303,730,178.46 -289,933,845.51 -95,109,937.04 XII. Others □ Applicable √ N/A 18 Joincare Pharmaceutical Group Annual Report 2022 Chapter 3 Management Discussion and Analysis I. Discussion and analysis of business operation 2022 was a crucial year for China to promote the implementation of the “14th Five-Year” Plan and the 30th anniversary of the establishment of Joincare. Facing the complex and volatile external environment and various unexpected hardships and challenge, the Company adhered to the corporate vision of “Diligently make high-quality and innovative drugs” and the core values of “Putting People First, Valuing Workmanship and Quality, Pursuing Innovation and Truth, Promoting Cooperation and Sharing”, and achieved sustained and stable growth by focusing on its principal business, fully leveraging its comprehensive strengths, increasing investments in R&D to improve its innovative capability, optimizing the product structure at a faster pace and adapting to the in- depth market-oriented reform and innovation of the marketing system. (I) Focusing on innovative drugs and high-barrier complex formulations to promote high- quality development Driven by R&D and innovation, the Company has been concentrating on developing innovative drugs and high-barrier complex preparations to meet the needs of patients. The Company carried out the R&D of differentiated products covering the full lifecycle of drugs, gradually broke through technological barriers in segmented industries and developed competitive advantages in the market. While deeply cultivating inhalation administration, sustained-release microspheres, antibody technology and other platforms with technical strength, the Company continued to develop and deploy on platforms for complex injections represented by nanocrystals and liposomes and constantly consolidated the leading position of the Company in the domestic high-end complex formulations. During the Reporting Period, the Company made a significant headway in developing multiple medicines in our R&D pipeline and sped up the innovation process. Tobramycin Solution for Inhalation (妥布霉素吸入溶液) was approved for market launch. The Recombinant SARS- CoV-2 Fusion Protein Vaccine (Likang) was successfully included for the emergency use for heterologous booster vaccination. Indacaterol Maleate Powder for Inhalation (马来酸茚达特罗吸 入粉雾剂) and Ilaprazole Sodium for injection (注射用艾普拉唑钠) with new indication had applied for production. Salmeterol Xinafoate-Fluticasone Propionate Powder for Inhalation (沙美 特罗替卡松吸入粉雾剂), Aripiprazole Microspheres for Injection (注射用阿立哌唑微球) (1- month sustained release), Recombinant Anti-human IL-17A/F Humanized Monoclonal Antibody for Injection (重组抗人 IL-17A/F 人源化单克隆抗体注射液) and XYP-001 were currently under clinical studies. The Company has been paying attention to the R&D of drug-device combinations. Two products developed by the Company have obtained the registration certificates of class II medical devices and one product has obtained the filing certificate for medical devices. While continuously strengthening independent innovation, the Company has been paying close 19 Joincare Pharmaceutical Group Annual Report 2022 attention to cutting-edge technologies, enhancing external cooperation and actively promoting innovative business cooperation models in global market. It has been actively seeking opportunities for frontier technology expansion and global product layout through cooperative development and licensing, among other means, to strengthen its commercialization and integration capabilities. The Company has been strengthening the licensing on introduction of products in core sectors, authorizing the introduction of various projects in the fields of respiratory, psychiatry and gastroenterology and expanding the R&D pipeline of the Group. It has made phased progress in collaborative projects. XYP-001 and Asenapine transdermal patch licensed-in were approved for clinical trials in China. Moreover, the Company succeeded in exporting its products under research, with its R&D strength gradually recognized by overseas markets. The Company is still continuously advancing international cooperation and licensing on innovative products and pipelines, and conducting negotiations on cooperation with various parties in the international community. For Tobramycin Inhalation Solution (妥布霉素吸入溶液), an modified new drug, the Company is conducting negotiations on licensing with customers in Europe, Southeast Asia and other regions. (II) Innovating a diversified marketing model to enhance corporate brand value In 2022, the marketing teams of prescription medicines actively implemented the sales strategies and completed the following key tasks: strengthening product and brand promotion, integrating resources of end-users, focusing on appraisal of hospitals at above grade II, and enhancing the hospital coverage of core brands and fulfillment rate of evaluation indicators. During the Reporting Period, the hospital coverage rate of key products continued to rise, and the overall sales revenues of prescription medicines showed a steady increase compared with the previous period. As Online and offline linkage of prescription drugs were enhanced, and with “patients” as the starting point, online digital marketing was continuously promoted, content construction on doctors intensified, diseases management knowledge spread, cooperation between hospitals and chain pharmacies deepened, and offline patient services, brand reputation and patient satisfaction improved. We continued to carry out evidence marketing, boost academic marketing and maintain close communication with domestic and international academic communities. Tobramycin Inhalation Solution (妥布霉素吸入溶液), Ilaprazole series(艾普拉唑系列) and other key products were incorporated into several core guides and clinical consensus. The clinical and pharmacoeconomic study for key products went on smoothly, boosting continuous growth of products. We actively follow up the implementation of policies on national medical reform, and two products are included into the 7th round national volume-based procurement to reduce the price and improve the accessibility to patients. Actively expanding overseas markets remained the focus for API marketing this year. Against the backdrop of the complicated and severe global economic situation and increasingly fierce competition in API sales in 2022, the sales team of the Company deeply explored in the market and advanced against headwinds, achieving remarkable performance. The Company increasingly became the preferred strategic partner of global leading pharmaceutical enterprises. Sales of high- 20 Joincare Pharmaceutical Group Annual Report 2022 end antibiotics and high-end pet drugs achieved remarkable growth. More than ten products further consolidated their advantages while maintaining the biggest market share in the global export market. In addition, after over ten years of development, the pet API of the Company occupied a large global market share, and it has established strategic partnerships with many multinational animal healthcare companies. The Company’s first pet formulation product - Imidacloprid and Moxidectin Spot-on Solutions (吡虫啉莫昔克丁滴剂)-had been launched for sale in 2022. (III) Attaching equal importance to quality and efficiency, and entering a new stage of internationalization Adhering to the concept that quality, safety and environmental protection are the lifeline, the Company conducted systematic control of quality and safety risks, improved the management mechanism, and increased investment in safety and environmental protection, to ensure production safety and stable quality of drugs. At the same time, the Company always adheres to the principle of sustainable development and integrates the concept of green development into operation and management processes. It promoted lean production of major products through green chemical technological means and the improvement and upgrading of equipment and facilities to improve the production efficiency, achieving comprehensive cost reduction and efficiency improvement. While constantly consolidating the foundation for environmental protection and safety, improving the quality study on existing products, optimizing the production process, and promoting the normalization of GMP, all production enterprises have been actively applying for international certification, thus the internationalization process is further accelerated. With respect to formulation products, the Company strengthened overseas market access, product registration and promotion of inhalation products, assisted reproductive products, gastroenterological products, antiviral products, etc. Ilaprazole Sodium for injection (注射用艾普 拉唑钠) and Ilaprazole Enteric-Coated Tablets (艾普拉唑肠溶片), key products of the Company, were approved to be launched for market in Indonesia. The work related to overseas registration of Recombinant Human Choriogonadotropin alfa for Injection (注射用重组人绒促性素) is being promoted, the submission of registration materials has been completed in Indonesia, Pakistan, five countries in Central and South America and 2 countries in Central Asia, and it has been approved to be launched for market in Tajikistan. Budesonide Suspension for Inhalation (布地奈德吸入混悬 液), Compound Ipratropium Bromide Solution for Inhalation (吸入用复方异丙托溴铵溶液) and other products are undergoing registration in the Philippines and other countries. Budesonide Suspension for Inhalation has completed registration in Macau and the company completed the first overseas sale of inhaled formulation products. With respect to APIs, during the Reporting Period, the Company obtained 4 international authentication certificates for APIs and intermediates, namely 1 EU GMP certificate for Teicoplanin (替考拉宁) and Vancomycin Hydrochloride (盐酸万古霉素); and 3 CEP certificates, namely the CEP certificate for Moxidectin (莫昔克丁), the CEP certificate for Acarbose (阿卡波糖) and the CEP certificate for Tobramycin (妥布霉素). 21 Joincare Pharmaceutical Group Annual Report 2022 (IV) Implementing scientifically-based lean management and improving the overall operating efficiency During the Reporting Period, the Company ensured that the management processes follow the development of the Company by improving the management efficiency through formulating and optimizing management processes and strengthening standardized operation and risk control. The Company raised higher requirements and targets on work related to the sustainable development, released appraisal rules on ESG indicators and actively performed social responsibilities. The Company intensified the management by an objective system with OKRs and KPIs in parallel, with full cooperation and support from all functional departments to provide strong services and guarantee for R&D, production and marketing, attached great importance to talent acquisition and team building, implemented the A/B role working mechanism, enhanced the working capability of employees, continued to introduce global high-end talents while strengthening identification, training and promotion of internal talents to ensure stability of the core talent team, actively disseminated the corporate culture and developed highly unified core values of enterprises to enhance their sense of happiness and enterprise identity, so as to achieve greater cohesiveness and affinity in the workplace. (V) Practicing corporate social responsibility to boost sustainable development The Company adhered to the path of green development and facilitated the achievement of “carbon peaking and carbon neutrality” targets with practical actions. Through the formulation of the “Energy Conservation and Emission Reduction Targets 2021-2025”, it continuously promotes all its production enterprises to carry out energy saving and emissions reduction and complete the environmental management targets for 2022. During the Reporting Period, the Company introduced the Environmental Management Targets on Carbon Emissions and strived to achieve carbon neutrality by 2055. While focusing on its own development, the Company always participates in social welfare initiatives and vigorously undertakes social responsibilities. The Group has actively responded to national policies and calls for years. In combination with its own industrial advantages, the Group jointly launched the “Access to Public Welfare for Chronic Diseases Prevention and Treatment ( 普 惠 慢 病 防 治 公 益 项 目 )”program, which currently covers 8 provinces and 1 autonomous region. It provided drugs and other materials for patients with chronic diseases in remote areas, alleviated their medical burdens and further improved the affordability of drugs. In addition, the Company actively conducted public welfare and science popularization activities, deeply spread knowledge on diseases through preparing videos on public welfare and science popularization, invited experts to conduct livestreaming on public welfare and science popularization, and hosted public welfare lectures. It carried out bronchiectasis assistance programs as well. Through the “Enterprise WeCom Expert’s little helper”, it provided one-to-one services for bronchiectasis patients and offered medication consultation, disease consultation, free expert diagnosis and other services. In 2022, the Company’s public welfare donations amounted to approximately RMB12.117 million. 22 Joincare Pharmaceutical Group Annual Report 2022 II. Overview on the industry in which the Company operates during the Reporting Period The pharmaceutical industry is a national strategic emerging industry bearing on the national economy and people's livelihood, and an important part of the national economy. According to the 14th Five-Year Plan for the Development of Pharmaceutical Industry(《“十四五”医药工业发展规 划》), the overall development of the pharmaceutical industry will reach a new level. During the "13th Five-Year Plan" period, the average annual growth rate of the added value of pharmaceutical industry above designated scale was 9.5%, 4.2 percentage points higher than the overall growth rate of all the industries, and the proportion of the total added value of the pharmaceutical industry to that of all the industries increased from 3.0% to 3.9%; the average annual growth rate of the operating revenues and total profit of enterprises above designated scale were 9.9% and 13.8%, respectively, being at the forefront of various industries in terms of growth rate. At the same time, the scale of leading pharmaceutical manufacturers has further expanded with the steadily increasing industry concentration. In 2022, with the deepening reform of the national medical and healthcare system and increasing improvement in the innovation environment, the pharmaceutical industry continued to advance towards high-quality development featuring transformation as well as upgrading and encouraging innovation. With the aging population and the increasing urbanization rate in China, from the long-term and holistic perspective, China's pharmaceutical industry will continue to present a promising development trend. The R&D expenditures in new drugs in the pharmaceutical industry remained high and the pipeline of new drugs under research was increasingly diversified. In 2022, 10 innovative chemical drugs, 31 modified new chemical drugs, 6 innovative biological drugs and 5 new TCM drugs were approved for market launch. The number of new drugs approved for market launch remained relatively stable. Meanwhile, the time from the launching of innovative drugs to the inclusion in the medical insurance system was shortened from the original 4-5 years to the current about 1 year. The application of innovative drugs with “clinical value” in hospitals was further accelerated. Data of National Bureau of Statistics shows that in 2022, enterprises in the pharmaceutical manufacturing industry above designated scale in China recorded revenues of RMB2,911.14 billion, representing a year-on-year decrease of 1.6%; operating costs of RMB1,698.46 billion, representing a year-on- year increase of 7.8%; and total profits of RMB428.87 billion, representing a year-on-year decrease of 31.8%. III. Overview on the businesses of the Company during the Reporting Period (I) Principal businesses and products of the Company The Company is primarily engaged in the R&D, production and sales of pharmaceutical products and health care products. The business scope of the Company covers chemical pharmaceuticals, biologics, chemical active pharmaceutical ingredients (APIs) and intermediates, traditional Chinese medicine, diagnostic reagents, equipment, health care products, etc. The comprehensive product series and mix provide larger market and growth opportunities for the Company. Main products of the Company are as follows: 23 Joincare Pharmaceutical Group Annual Report 2022 (II) Business model of the Company With the stable operation and rapid development over the years, the Company has become an integrated pharmaceutical group that is driven by scientific research and innovation, integrating the R&D, production, sale and service of pharmaceutical and health care products. It has complete systems of R&D, procurement, production and sale. Main business models of the Company are as follows: 1. R&D Taking independent R&D as the mainstay and combining external introduction and cooperative development, the Company has been paying attention to the cutting-edge technology and unmet clinical needs, with efforts focused on innovative drugs and high-barrier complex formulations and has established an efficient R&D innovation management model. In terms of independent innovation, the Company has a diversified and multi-dimensional R&D organization with mature R&D teams for chemical pharmaceuticals, biologics, TCM drugs, APIs, diagnostic reagents and health care products. Based on technology platform construction, the Company has built a clear product R&D pipeline centering on key areas such as respiratory, tumor immunity and psychiatry. In terms of cooperative innovation, the Company has launched technical cooperation with domestic and foreign scientific research institutions by way of commissioned development or cooperative development, and has introduced new technologies and products that meet the strategic development goal of the Company through technology transfer or license-in to implement industrial 24 Joincare Pharmaceutical Group Annual Report 2022 transformation, so as to reinforce and strengthen our position and strategy in the leading and emerging fields. 2. Procurement In terms of procurement, the Company pays strict attention to effectiveness, quality and cost of procurement and has established long-term and stable partnership with many suppliers. Active pharmaceutical ingredients, supplementary materials, and packaging materials were purchased and stocked up by manufacturers according to production schedules. The Company has developed strict quality standards and procurement management systems and required subordinate manufacturers to make procurements in accordance with the GMP. Meanwhile, the Company established long-term strategic partnerships with bulk material suppliers, and strengthened the management of supply quality and cost control based on strict quality standards. The Company has established an internal evaluation system and files of market prices so as to promptly acquire market information for procurement through comparisons of quality and price. 3. Production In terms of production, the Company adopts the principle of market demand-oriented approach paying attention to real market demand. Specifically, the Sales Department of the Company investigated market demands, made sales plans, and comprehensively considered factors such as the product inventory quantity and capacity of production lines of the Company so as to determine the monthly production quantities and specifications. Moreover, the purchase orders of raw materials are determined according to the production schedule and the inventory levels of raw materials. The final production plans are issued upon approval of the management of the Company and implemented by the Production Technology Department of the Company. The Company has been carrying out production in strict accordance with the GMP. The Company and its affiliates have established a sound quality management system and implemented the qualified-person system. In terms of quality control, the Company has established a strict and sound production quality assurance system, and is geared to international standards and subject to international certification while in compliance with national standards. The Company conducts annual GMP self-inspection, ISO9001 internal and external audits, and is subject to various external audits. It actively pursued the internationally advanced GMP management, and implemented whole- process quality control over supplier selection, audit, incoming material inspection, production process, product release from factory, and market tracking. The system is running well. 4. Sales (1) Drug formulation products End customers of drug formulation products (chemical pharmaceuticals, biologics, traditional Chinese medicine) of the Company are mainly hospitals, clinics, and retail pharmacies. In line with 25 Joincare Pharmaceutical Group Annual Report 2022 the pharmaceutical industry practice and the sales model of most peers in the industry, the Company has conducted sales of drug formulation products through drug distribution enterprises. The Company carried out selection and centralized management of qualified drug distribution enterprises (with Drug Supply Certificate, GSP Certification, etc.) according to their distribution capability, market familiarity, financial strength, credit record, and operation scale. General sales process: After end customers place purchase orders to distribution enterprises, drug distribution enterprises will send those orders to the Company according to their inventories, distribution agreements and conditions; then, the Group will deliver products to drug distribution enterprises and do the revenue recognition. (2) APIs and intermediates Main target customers of APIs are large pharmaceutical manufacturers. The selling prices are determined based on a set of integrated factors such as costs of production, inventory levels, industry rivalry and market trend. Specific pricing method: The sales and marketing department conduct weekly or bi-weekly meetings to analyze the current market conditions, the trends and drivers of prices; the selling prices are determined based on a set of comprehensive factors such as costs of production, inventory levels, industry rivalry and market conditions; the selling prices will be effective once are reported by the managers of the sales department to our management team and get approvals. Specific sales methods of APIs include: ① Domestic market: The Company directly signs product sales contracts with large manufacturers to directly sell products to customers. Meanwhile, the Company also sells products through distributors. ② Foreign market: The Company directly sells products in the foreign market and in areas with high market and political risks, products are sold through distributors. At present, products of the Company are mainly exported to over 60 countries and regions in Asia, Europe, North America, and Africa. (3) Diagnostic reagents and equipment Diagnostic reagents and equipment sold by the Company both domestically manufactured and imported. Main end customers are hospitals, centers for disease control and prevention, and health departments. The Company mainly sells those products in combination with direct sales and sales through drug distribution enterprises. The Company has an experienced sales team responsible for the sales of diagnostic reagents and equipment, with provision of marketing support for some drug distribution enterprises. The Company carried out selection and centralized management of qualified drug distribution enterprises (with Drug Supply Certificate, GSP Certification, etc.) according to their distribution capability, market familiarity, financial strength, credit record, and operation scale. 26 Joincare Pharmaceutical Group Annual Report 2022 (4) Health care products The sales model of health care products is mainly distributor management model. Product promotion, price control, and channel carding are managed and improved with the distributor distribution channel and terminal coverage capability. At present, the Company has set up 25 provincial branches and 92 subordinate offices across China and maintained long-term partnership with distributors with better area coverage capability for stable strategic alliance and common development. The Company has cooperated with about 103 first-level/primary distributors in total, including 78 businesses in drug distribution line and approximately 25 businesses in food distribution line with more than 150,000 subordinate secondary businesses and terminal businesses in drug and food distribution lines. Products are well managed and promoted through the tiered marketing channel. In addition to the traditional distribution management model, the Company realizes synergetic development through online channels. At present, the Company has set up official flagship stores on mainstream e-commerce platforms such as Tmall(天猫), Jingdong(京 东), Douyin(抖音), Kuaishou (快手) and Pinduoduo (拼多多). (III) Industry status of the Company Through years of development, the Company has become a comprehensive pharmaceutical enterprise covering multiple areas including chemical pharmaceuticals, biologics, chemical APIs and intermediates, traditional Chinese medicine, diagnostic reagents and equipment, health care products, etc. In terms of revenues in 2021, the Company ranked sixth among the listed integrated pharmaceutical enterprises in China. Chemical pharmaceuticals are the largest revenue generator of the Company, among which gastroenterological products, anti-infection products and gonadotropic hormones products are traditional competitive products of the Company, with key products securing a long-standing leading position in national drug formulation market segment. Respiratory and psychiatric products have been the focus of the Company, with key products maintaining a strong sales growth momentum. In terms of R&D expenditures in 2021, the Company ranked fifth among listed integrated pharmaceutical enterprises in China. During the Reporting Period, with solid strength in R&D, production, and steady marketing presence, the Company ranked Top 10 in 2021 Annual Ranking of Top 100 Chinese Chemical Drug Enterprises and Top 100 in the “2022 Annual Ranking of Chinese Pharmaceutical R&D Comprehensive Strength”. (IV) Performance drivers during the Reporting Period In 2022, the Company actively implemented sales deployment, strengthened market promotion and reinforced sales specialization. In addition, the Company increased digital marketing and enhanced delicacy management. That is how we can realize steady growth of main business revenues and consolidate the foundation and ability of sustainable development of enterprises. During the Reporting Period, sales of main varieties in key specialist areas, especially in fields of respiratory 27 Joincare Pharmaceutical Group Annual Report 2022 and psychiatry of the Company, kept steady growth, and contribution of sales revenues from key preparation products to overall revenues was continuously improved. In addition, the proportion of sales and profit of high-end APIs increased as the Company has been taking measures to integrate resources, optimize product structure, and reinforce international certification while actively using advanced technologies including synthetic biology and continuous production to ensure green production. IV. Analysis of core competitive strengths during the Reporting Period √Applicable □N/A 1. Leading integrated pharmaceutical company under continuous innovation and development in China The Company is primarily engaged in the R&D, production and sale of pharmaceutical products and health care products. The business scope of the Company covers chemical pharmaceuticals, biologics, chemical APIs and intermediates, TCM drugs, diagnostic reagents and equipment, as well as health care products, allowing the Company to establish competitive advantages across various therapeutic areas such as respiratory, anti-infection, assisted reproduction, gastroenterology, psychiatry, and tumor immunity. 1) Innovative R&D drives growth: The Company has developed and launched a number of innovative medicine products and high-barrier complex formulation products, strengthening the Group’s product portfolio and drug candidates in the pipeline. 2) The Company has first-tier commercialization ability, and its sales network covers all provinces in China and over 80 overseas countries and regions in the world. The Company emphasizes scientific promotion and evidence-based marketing. By building a professional marketing team, the Company has established a comprehensive marketing system, and market education and brand building have been deeply strengthened through digital marketing. Leveraging our comprehensive sales channels, broad market coverage, leading digital marketing and brand awareness, the Company is able to sell the products at scale in an efficient manner. 3) Cross-industry and multi-specialist innovative R&D and coordinated development: On one hand, the Company actively adapts to the changes in the pharmaceutical market and constantly adjusts its product strategy and R&D direction according to policies and clinical needs. This will realize the continuous iteration and upgrade of the main products. On the other hand, the Company fully utilizes external scientific research and commercial resources, such as strategic collaboration with Chinese Academy of Sciences, Tencent Quantum Lab and other scientific research institutes and innovative companies and invests in cutting-edge biotechnology companies to expand the Company’s product portfolio and R&D pipeline, thus realizing the Company’s sustainable development. 28 Joincare Pharmaceutical Group Annual Report 2022 2. Strong R&D capabilities, diversified product portfolio and leading commercialization capabilities Focusing on innovative medicines and high-barrier complex formulation, the Company has formed diversified product portfolio. With the huge clinical demand and high product quality, it has established market competitive advantages in many pharmaceutical segments. The Company’s chemical pharmaceuticals cover gastroenterology, assisted reproduction, anti-infection, respiratory, psychiatry, tumor and other fields, among which alimentary tract proton pump inhibitor (PPI) drugs, gonadorelin hormone drugs, and inhalation formulation for respiratory diseases have an advantageous market position. Relying on APIs production, the Company’s core products, together with our chemical APIs and intermediates, form an integrated and stable pharmaceutical industrial chain of “APIs-formulations vertical integration”. Meanwhile, the Company actively develops overseas markets, and our products are marketed and distributed worldwide, facilitating strategic cooperation with many internationally renowned pharmaceutical companies. In addition, the Company also has a number of TCM drugs and in vitro diagnostic reagent products and has accumulated resources and extensive brand influence in healthcare products for many years. 3. Making breakthroughs in the key R&D and industrialization technologies of complex formulation The technology platform, which has been developed over the years in the field of innovative medicines and high-barrier complex formulation, enables the Company to address the complex process problems in the R&D and production of relevant drugs. Guided by clinical value, the Company develops R&D projects with high short-term certainty and cutting-edge technologies with long-term growth potential (such as AI-driven drug molecular design, proteolysis targeted chimeric (PROTAC), synthetic biology, gene-editing, cellular treatment, etc.). All in all, the Company’s R&D system covers through-cycle of drug development and production. Based on the mature R&D platform of innovative drugs and high-barrier complex formulations, the Company has designed extensive pipeline in fields with significant clinical demand such as respiratory, gastroenterology, assisted reproduction, psychiatry, and tumor. 4. Stable management and R&D team with expertise, long-term vision and commitment to social responsibility The Company has a stable, visionary and experienced, results-oriented management team and an outstanding talent team. Outstanding leaders are the key to the Company’s rapid development. The founder of the Company has over 30 years of expertise in the pharmaceutical industry as well as a global vision and a strategic mindset. With a deep industry insight, the founder has led us develop platform technologies centered on high-barrier complex formulations, which has established leading position of the Group with sustainable development in the broader healthcare industry. The senior 29 Joincare Pharmaceutical Group Annual Report 2022 management team of the Company has over 20 years of industry experience on average, with an average of more than 10 years of service in the Company, and has a thorough understanding of market demand, industry development and growth opportunities. Each key R&D field of the Company is led by industry-leading scientists and accompanied by an efficient R&D management team. In addition, the Company has upheld the core value of “Putting People First, Valuing Workmanship and Quality, Pursuing Innovation and Truth, Promoting Cooperation and Sharing” and laid emphasis on talent team training to build a diversified reserve of talents with global vision, advanced knowledge, strong implementation capability and sense of self-reliance. Driven by the corporate culture of pursuing excellence, the talent team works diligently and conscientiously to jointly contribute to the sustainable development of the enterprise through teamwork and collaboration. V. Overview of business operations during the Reporting Period During the Reporting Period, the Company realized revenues of RMB17,143 million, representing a year-on-year increase of approximately 7.79%; a net profit attributable to shareholders of the listed company of RMB1,503 million, representing a year-on-year increase of approximately 13.10%, and a net profit attributable to shareholders of the listed company after deducting the extraordinary gains or loss of RMB1,419 million, representing a year-on-year increase of approximately 15.84%. In 2022, business development of various segments of the Company is as follows: (1) Livzon Group (excluding Livzon MAB) As at the End of the Reporting Period, the Company directly and indirectly held 44.77% equity interest in Livzon Group (000513.SZ, 01513.HK). During the Reporting Period, Livzon Group (excluding Livzon MAB) realized revenues of RMB12,424 million, representing a year-on-year increase of approximately 3.35%; and realized a net profit of approximately RMB1,038 million attributable to shareholders of the Company. During the Reporting Period, the sales of the drug formulation segment of Livzon Group increased steadily, and recorded the steady growth in the proportion and profitability of high-end specialty APIs in the API segment. The sales of its products in the key therapeutic areas are as follows: Gastroenterology products realized revenues of RMB3,436 million, representing a year-on-year decrease of approximately 6.48%; gonadotropic hormones products realized revenues of RMB2,591 million, representing a year-on-year increase of approximately 5.64%; and psychiatry products realized revenues of RMB545 million, representing a year-on-year increase of approximately 32.19%. (2) Livzon MAB As at the End of the Reporting Period, the equity interest directly and indirectly held by the Company in Livzon MAB was 55.90%, and the amount affecting the Company's net profit attributable to the parent company for the current period was approximately RMB-446 million. 30 Joincare Pharmaceutical Group Annual Report 2022 During the Reporting Period, Livzon MAB focused on promoting the application on conditional marketing approval of the Recombinant SARS-CoV-2 Fusion Protein Vaccine (重组新型冠状病 毒融合蛋白疫苗) (Likang). Livzon MABcompleted the Phase III clinical master analysis report for sequential immunization and basic immunization and submitted related application materials to CDE in February and May 2022, respectively. It was approved for the domestic heterologous booster vaccination in June 2022 and was officially included into the national immunization plans in September of the same year. Currently, it has been applied in the booster vaccination in over 20 provinces and municipalities across China. To meet the market demand, Livzon MAB has completed the construction of the third preparation workshop (2-tests and 10-tests production line), which has been fully put into operation, on the basis of the existing 1 stock solution production line and 2 preparation production lines. In addition, in response to the global trend of COVID-19 pandemic and the prevalence of COVID-19 variants, Livzon MAB developed several vaccines against the variants and related bivalent vaccines and carried out explorations on enhanced immunization with portfolios of various types of vaccines. During the Reporting Period, Livzon MAB carried out the R&D of bivalent vaccine BV-01-B5 on prototype strain + Omicron strain. Data showed that BV-01-B5 has outstanding cross-neutralization effects on Omicron BA.4/5 and other subtypes. Currently, complete clinical application materials for the bivalent vaccine have been submitted and are under CDE’s review. On the other hand, Livzon MAB continued to focus on new molecules, new targets and differentiated molecular designs in the fields of tumors, immune diseases and assisted reproduction. During the Reporting Period, Livzon MAB made phased progress in the R&D of the following projects: Recombinant Human Choriogonadotropin alfa for Injection (注射用重组人绒促性素) was approved for launching in 2021 and had started sales, which is the first generic drug of its kind in China. Livzon MAB had been actively promoting overseas registrations. Its submission of registration materials had been completed in Indonesia, Pakistan, five countries in Central and South America and 2 countries in Central Asia and the drug had been approved for launching in Tajikistan. The application for launch approval on Tocilizumab Solution for Injection (托珠单抗注射液) (i.e. Recombinant Humanized Anti-human IL-6R Monoclonal Antibody Solution for Injection (重组人 源化抗人 IL-6R 单克隆抗体注射液) , with the indication of rheumatoid arthritis, had been approved. Meanwhile, it was listed in the Diagnosis and Treatment Protocol for COVID-19 (Trial Version 10) and the Diagnosis and Treatment Protocol for Severe COVID-19 Cases (Trial Version 4). With tight domestic supply of brand-name drugs at the end of 2022 and the beginning of 2023, the approval for market launch of Tocilizumab Solution for Injection of Livzon MAB relieved the tight supply to a certain extent. The phase II clinical trials for Recombinant Anti-human IL-17A/F Humanized Monoclonal Antibody for Injection (重组抗人 IL-17A/F 人源化单克隆抗体注射液) were completed and Livzon MAB was about to conduct the phase III clinical trials. Results showed that such product has fast action, outstanding efficacy, long maintenance of efficacy and other clinical advantages. It has better efficacy than IL-17A single-target drug and is expected to provide 31 Joincare Pharmaceutical Group Annual Report 2022 better solutions for psoriasis treatment in China. Moreover, the product with ankylosing spondylitis indication jointly applied for clinical trial by Livzon MAB and Beijing Kanova was under the preliminary analysis of interim data of the phase II clinical trials. In addition to advancing projects in the clinical phase, Livzon MAB is also exploring through R&D in areas such as bispecific antibodies and NKT cell therapy. With more and more products approved for market launch, Livzon MAB expanded its pharmacovigilance, production quality, production and sales linkage and other relevant teams, gradually enhanced the GMP system and industrialization capability and improved the overall operational capability. (3) Joincare (excluding Livzon Group and Livzon MAB) During the Reporting Period, Joincare (excluding Livzon Group and Livzon MAB) realized revenues of RMB4,832 million, representing a 17.04% year-on-year increase of approximately, and realized a net profit attributable to shareholders of listed companies of RMB929 million, representing a year-on-year increase of approximately 43.00%. Joincare realized a net profit attributable to shareholders of the listed company after deducting the extraordinary gains and losses of RMB863 million, representing a year-on-year increase of approximately 39.73%. Key results of the main business segments are as follows: ① Prescription medicines During the Reporting Period, Joincare (excluding Livzon Group and Livzon MAB) realized sales revenues of RMB2,120 million from prescription drug segment, representing a year-on-year increase of approximately 18.46%. Among which, the sales revenues and year-on-year change of key therapeutic areas are as follows: the revenues generated from the field of respiratory totaled RMB1,174 million, representing a year-on-year increase of 103.37%; the revenues generated from the field of anti-infection totaled RMB921 million, representing a year-on-year decrease of 22.76%. In 2022, the Company gradually enhanced the national sales team in respiratory line, established a three-level fine marketing development system of regional managers, provincial managers, and development managers, actively taking various measures to speed up the penetration of key products into hospitals: 1. The coverage and fulfillment rate of evaluation indicators were enhanced; the development speed of respiratory variety was obviously accelerated; drug formulary expansion of more than 2,200 hospitals above grade II was newly conducted throughout the year; 2. Rapid coverage and sales growth of the Levosalbutamol Hydrochloride Nebulizer Solution (盐酸左沙丁 胺醇雾化吸入溶液) was realized by taking the opportunity that the drug was included in the China’s National Reimbursement Drug List (“NRDL”); 3. Construction of digital marketing platforms was continuously advanced, marketing process accelerated through digital means and the brand comprehensively communicated via the platform of “Respiratory Experts' Views” (呼吸专家说); 4. With three inhalation formulations being included to the fifth batch of the volume-based procurement and one inhalation formulation being included to the seven batch of the volume-based 32 Joincare Pharmaceutical Group Annual Report 2022 procurement, the Company has rapidly tapped into the domestic sales market and gradually improved market share for inhalation formulation products; 5. Construction of regional warehouses in 10 regions across the country completed, including Shijiazhuang, Wuhan and Zhengzhou and were put into operation in 2022, which effectively ensured the timely and efficient distribution of drugs. ② APIs and intermediates During the Reporting Period, Joincare (excluding Livzon Group and Livzon MAB) realized sale revenues of RMB2,360 million from APIs and intermediates segment, representing a year-on-year increase of approximately 16.05%. During the Reporting Period, in the API segment, Joincare adhered to the management concept of “green production, cost reduction and efficiency enhancement”, focused on the transformation and upgrading of production equipment, enhanced the establishment of the quality management system and strengthened the construction of safety and environmental management, guaranteeing the steady improvement in the production and yield of key products of the Company. In terms of marketing, Joincare actively expanded domestic and international markets for the key product 7-ACA by optimizing strategic cooperation channels and strengthening in-depth cooperation with strategic customers. Leveraging the advantages in the upstream and downstream industry chains, we continued to increase our market share. The export share of Meropenem Trihydrate (美罗培南混 粉) has repeatedly set a new high. Despite increased competition in the market this year, the Company continued to strengthen its position in the market through making plans in advance, thus the sales and profit of the product hit a historical high. In addition, the Company applied the registration for Meropenem Trihydrate and Meropenem Crude (美罗培南粗品) in Japanese market and Italian market, respectively, boosting market development efforts for the products to expand overseas market share. With the implementation of the centralized procurement of Meropenem for injection, the Company displayed the advantages of APIs-preparations vertical integration and actively explored domestic API markets in response to the impacts of centralized procurements. In terms of API R&D, the Company focuses on two frontier fields to carry out key scientific research. Firstly, through the transformation and selection systems previously established and in combination with metabolic engineering, gene editing, systems biology, enzyme directed evolution, high- throughput screening and other technologies, the Company further optimized conditions for all processes of genetic modification, gene editing and strains selection. The Company has obtained more than 450 potential Cephalosporin C (头孢菌, CPC) high-yielding mutant strains from over 65,000 acremonium chrysogenum (产黄支顶孢霉) strains in the initial screening. It obtained 3 new CPC high-yielding mutant strains for large-scale industrial fermentation through selection, which made the average CPC yield per unit increased remarkably. Secondly, leveraging on the computer- assisted protein engineering technology platform and through the omics research, rational transformation and metabolic regulation on strains, the Company successfully developed screening 33 Joincare Pharmaceutical Group Annual Report 2022 strategies on metabolite biosensor applicable to aromatic amino acid and its intermediate products relying on the optimization of metabolic pathways guided by machine learning. Moreover, the Company made phased progress in the selection of doramectin, Acarbose, pleocidin, erythrocin, vitamin B2, levodopa, α-arbutin and other industrial strains and in the improvement of production process. ③ Health care products and OTC drugs During the Reporting Period, Joincare (excluding Livzon Group and Livzon MAB) realized revenues of RMB309 million from health care products and OTC segment, representing a year-on- year increase of approximately 7.24%. During the Reporting Period, the Company established a data-driven digital marketing system with user operation as the core to drive sales growth. On content marketing front, it focused on strengthening its exposure on social media platforms such as Douyin, RED(小红书) and WeChat, established cooperative relationships with several professional KOLs and promoted brands and products through graphics, short videos and livestreaming, to greatly enhance its brand exposure and at the same time to spread common knowledge on healthcare. In terms of brand marketing, it jointly unveiled the White Paper on Melasma Prevention and Treatment with industry associations and professional physicians, carried out common knowledge education and conveyed scientifically- based health concepts to foster its professional brand image and reputation. In terms of channel sales, in addition to maintaining the existing sales model of offline channels, we focused on expanding businesses through online channels such as Tmall, JD.com and Douyin to increase the penetration rate of channels, thereby boostering brand sales. (I) Analysis of principal business 1. Analysis of changes in items of income statement and cash flows statement Unit: Yuan Currency: RMB Amount for the same Item Amount for the period Change (%) period of last year Revenues 17,142,753,068.82 15,903,688,266.59 7.79 Operating costs 6,252,265,308.40 5,716,293,887.58 9.38 Selling expenses 4,950,802,456.16 5,026,812,145.41 -1.51 Administrative expenses 992,483,591.51 939,253,444.33 5.67 Financial expenses -352,447,424.62 -92,894,751.72 N/A R&D expenses 1,742,088,079.94 1,397,131,273.33 24.69 Net cash flow from operating 3,977,705,139.29 2,563,089,045.24 55.19 activities Net cash flow from investing activities -2,252,167,188.62 -1,964,157,731.17 N/A Net cash flow from financing 566,122,659.80 -974,904,353.44 N/A activities 34 Joincare Pharmaceutical Group Annual Report 2022 Reasons for changes in financial expenses: Mainly due to the increase in interest income and the increase in foreign exchange gains as a result of exchange rate changes during the Period. Reasons for changes in net cash flow from operating activities: Mainly due to the combined effect of an increase in sales receipts and a decrease in payment of marketing expenses during the Reporting Period. Reasons for changes in net cash flow from financing activities: Mainly due to the combined effect of new borrowing and investment absorption (through GDR issuance) during the Reporting Period. Details of material changes in business type, components or source of profits during the current period □Applicable √N/A 2. Analysis of revenues and costs √Applicable □N/A During the Reporting Period, the Company realized revenues of RMB17,143 million, representing a year-on-year increase of 7.79%; the operating costs totaled RMB6,252 million, representing a year-on-year increase of 9.38%. (1). Composition of principal businesses by industry, product, region and sales model Unit: Yuan Currency: RMB Principal business by industry YoY YoY YoY change in Gross profit change in change in By industry Revenues Operating costs gross profit margin (%) revenues operating margin (%) (%) costs Pharmaceutical Decreased by manufacturing 17,005,972,382.14 6,157,580,341.92 63.79 8.03 9.90 0.62 percentage Industry points Decreased by Service industry 6,761,356.72 2,750,242.27 59.32 34.89 55.02 5.28 percentage points Principal business by product YoY YoY YoY change in Gross profit change in change in By product Revenues Operating costs gross profit margin (%) revenues operating margin (%) (%) costs Increased by Chemical 9,226,385,569.43 1,813,969,087.68 80.34 3.94 3.44 0.09 percentage pharmaceuticals points Chemical APIs Increased by and 5,229,641,907.04 3,409,781,896.55 34.80 11.50 7.06 2.70 percentage intermediates points Traditional Decreased by Chinese 1,296,583,761.24 427,894,665.07 67.00 16.88 44.89 6.38 percentage medicine points Diagnostic Decreased by reagents and 723,535,115.00 352,636,503.06 51.26 -0.05 10.49 4.65 percentage equipment points Decreased by Biologics 408,488,131.90 106,811,638.64 73.85 80.94 568.08 19.07 percentage 35 Joincare Pharmaceutical Group Annual Report 2022 points Decreased by Health care 121,235,545.22 46,223,021.02 61.87 5.27 37.35 8.91 percentage products points Principal business by region YoY YoY YoY change in Gross profit change in change in By region Revenues Operating costs gross profit margin (%) revenues operating margin (%) (%) costs Decreased by Domestic 14,170,771,017.92 4,326,229,111.25 69.47 7.56 12.73 1.40 percentage points Increased by Overseas 2,841,962,720.94 1,834,101,472.94 35.46 10.51 3.80 4.17 percentage points Principal business by sales model YoY YoY YoY change in Gross profit change in change in By sales model Revenues Operating costs gross profit margin (%) revenues operating margin (%) (%) costs Decreased by Channel sales 11,185,248,628.68 2,566,303,271.29 77.06 4.51 11.47 1.43 percentage points Increased by Direct sales 5,827,485,110.18 3,594,027,312.90 38.33 15.54 8.83 3.80 percentage points Note: Biological products include Recombinant SARS-CoV-2 Fusion Protein Vaccine (重组新型 冠状病毒融合蛋白疫苗), Mouse Nerve Growth Factor for Injection (注射用鼠神经生长因子), Bifidobacterium Viable Capsule (双歧杆菌活菌胶囊), Recombinant Human Choriogonadotropin alfa for Injection (注射用重组人绒促性素), etc. Explanations on composition of principal businesses by industry, product, region and sales model During the Reporting Period, the Company’s principal businesses generated revenues of RMB17,013 million, representing a year-on-year increase of RMB1,266million or 8.04%. The growth of the Company’s revenues of principal businesses was primarily due to the Company’s continuous efforts in promoting marketing reforms, fully facilitating the mass market product channels and accelerating sales in key specialist fields. Sales of main varieties in the key fields of chemical pharmaceuticals kept sustained robust growth. In addition, the sales revenues of APIs segment grew noticeably with an obvious increase of gross profit margin as the Company taken measures to integrate resources, adjust product portfolio, reinforce international certification while actively using advanced technologies including synthetic biology and continuous production to ensure green production. (2). Analysis of production and sales √Applicable □N/A 36 Joincare Pharmaceutical Group Annual Report 2022 YoY YoY YoY change in Main Inventory change in Unit Production Sales change in Inventory products level production sales (%) (%) (%) Ilaprazole Ten sodium for thousand 1,866.33 1,956.16 225.38 29.94 57.12 -28.71 injection boxes Leuprorelin Ten Acetate thousand 151.98 151.94 - -2.39 10.47 - Microspheres ampules for Injection Ilaprazole Ten Enteric- thousand 2,502.09 2,257.23 482.82 28.25 9.82 101.71 Coated boxes Tablets Ten Meropenem thousand 1,873.59 2,011.01 13.32 2.59 1.71 -91.16 for Injection ampules 7-ACA (including D- Ton 3,065.58 3,018.95 102.50 5.57 1.07 83.43 7ACA) Explanations on production and sales In 2022, the Company actively implemented sales planning, stepped up efforts in marketing, and enhanced specialized and fine sale management, thus leading to significant increase in the output and sales volume of our major product, Ilaprazole sodium for injection. The change in inventory was mainly due to the supply and demand at the end of the year and the stock preparation for the new year. (3). Performance of major procurement contracts and major sales contracts □Applicable √N/A (4). Cost analysis Unit: Yuan As a As a percentage percentage Amount incurred of total Amount incurred YoY Cost of total in the same costs in By industry in the current change components costs in period of the same period (%) the current previous year period of period (%) previous year (%) Costs of 3,908,782,585.27 62.52 3,426,827,118.77 59.95 14.06 materials Labor costs 809,277,538.94 12.94 619,622,563.47 10.84 30.61 Pharmaceutical Manufacturing manufacturing 1,684,532,284.52 26.94 1,487,278,456.52 26.02 13.26 costs Industry Depreciation 406,107,662.76 6.50 322,761,251.80 5.65 25.82 Others -559,185,005.37 -8.94 -141,969,567.28 -2.48 N/A Subtotal 6,249,515,066.13 99.96 5,714,519,823.28 99.97 9.36 Service Costs of 512,284.05 0.01 408,782.66 0.01 25.32 37 Joincare Pharmaceutical Group Annual Report 2022 industry materials Labor costs 1,757,712.56 0.03 1,022,280.28 0.02 71.94 Manufacturing 327,719.99 0.01 223,280.63 0.00 46.77 costs Depreciation 152,525.67 0.00 119,720.73 0.00 27.40 Subtotal 2,750,242.27 0.04 1,774,064.30 0.03 55.02 Costs of 3,909,294,869.32 62.53 3,427,235,901.43 59.96 14.07 materials Labor costs 811,035,251.51 12.97 620,644,843.75 10.86 30.68 Manufacturing Total 1,684,860,004.51 26.95 1,487,501,737.14 26.02 13.27 costs Depreciation 406,260,188.43 6.50 322,880,972.53 5.65 25.82 Others -559,185,005.37 -8.94 -141,969,567.28 -2.48 N/A Subtotal 6,252,265,308.40 100.00 5,716,293,887.58 100.00 9.38 As a As a percentage percentage Amount incurred of total Amount incurred YoY Cost of total in the same costs in By product in the current change components costs in period of the same period (%) the current previous year period of period (%) previous year (%) Costs of 36,089,962.70 0.58 26,560,959.72 0.46 35.88 materials Labor costs 11,329,854.63 0.18 6,336,694.50 0.11 78.80 Health care Manufacturing 9,444,348.04 0.15 2,677,541.36 0.05 252.72 products costs Depreciation 5,463,682.37 0.09 2,564,510.61 0.04 113.05 Others -16,104,826.72 -0.26 -4,487,206.18 -0.08 N/A Subtotal 46,223,021.02 0.74 33,652,500.02 0.59 37.35 Costs of 3,841,254,506.51 61.44 3,359,165,272.77 58.76 14.35 materials Labor costs 795,400,898.83 12.72 611,624,924.03 10.70 30.05 Pharmaceutical Manufacturing 1,620,338,814.98 25.92 1,435,952,937.90 25.12 12.84 Products costs Depreciation 400,238,957.27 6.40 320,084,243.85 5.60 25.04 Others -546,139,386.60 -8.74 -157,879,982.96 -2.76 N/A Subtotal 6,111,093,791.00 97.74 5,568,947,395.59 97.42 9.74 Other information on cost analysis Cost and variety of main medicinal herbs used in main TCMs Variety of main Procurement Main TCMs Supply and demand Influence of price fluctuation medicinal herb model The supply of Livzon Limin’s codonopsis root and astragalus root is Codonopsis Root: the supply relatively stable. Both medicinal price fall compared with the Shenqi herbs are supplied by plantation bases Supplied by same period last year; Fuzheng and external suppliers. Plantation Livzon Limin Astragalus Root: the supply Codonopsis Root Injection(参芪 Base of Livzon Limin Pharmaceutical Base and maintained relatively stable, and Astragalus Root 扶正注 Manufacturing Factory (“Livzon external and the supply price edged up 射液) Limin Base”) maintains safety stock suppliers due to the increase in of medicinal herbs, which ensures the processing costs, labor costs supply quantity and stabilizes the and other expenses. supply price. Meanwhile, Limin 38 Joincare Pharmaceutical Group Annual Report 2022 signed annual demand-based supply agreements with external suppliers who are obligated to stock up according to Limin's quality requirements, so as to ensure sufficient supply of herbs with stable quality. For main raw medicinal herbs used in Anti-Viral Granules, compared with the same period of the previous year, price of Rehmanniae Radix fell largely as the plantation area was supplemented stimulated by the high price at There is sufficient supply of main raw the earlier stage; price of Indigowoad Root, medicinal herbs used in Anti-Viral Radix Curcumae decreased as Fructus Forsythiae, Granules. Indigowoad Root, Acori Anti-Viral results of expansion of the Anemarrhena, Acori Graminei Rhizome, Anemarrhena, Tendering Granules, plantation area; the prices of graminei Rhizoma, Patchouli, Rehmanniae Radix and procurement, Anti-Viral some medicinal herbs such as Gypsum, Rhizoma Radix Curcumae are supplied by supplied by Granules Indigowoad Root, Fructus Phragmitis, plantation bases and external plantation base (Sugar-free), Forsythiae, Rhizoma Patchouli, suppliers; some wild medicinal herbs and external Anti-Viral Phragmitis, Patchouli, Rehmanniae Radix, such as Fructus Forsythiae and Acori suppliers Syrup, Anti- Anemarrhena, Acori graminei Radix Curcumae, Graminei Rhizome have a certain Viral Tablets Rhizoma stayed relatively the Dahurian Angelica amount of safety stock to ensure same. However, as the Root basically stable supply and price. demand for certain varieties of medicinal herbs such as Indigowoad Root, Fructus Forsythiae, Rhizoma Phragmitis and Patchouli increased significantly in the market at the end of 2022, their prices rose to varying degrees. (5). Changes in consolidation scope due to equity change of major subsidiaries during the Reporting Period □Applicable √N/A (6). Material changes or adjustments in business, products or services during the Reporting Period □Applicable √N/A (7). Major customers of sales and major suppliers A. Major customers of sales √Applicable □N/A Sales to the top 5 customers were RMB1,524.4901 million, representing 8.89% of the total annual sales; of which the sales to related parties were RMB0 million, representing 0.00% of the total annual sales. Sales to any individual customer in excess of 50% of the total, any new customer in the top 5 customers or heavy dependence on a few customers during the Reporting Period □Applicable √N/A 39 Joincare Pharmaceutical Group Annual Report 2022 B. Information on major suppliers √Applicable □ N/A Purchases from top 5 suppliers were RMB835.906 million, representing 17.24% of the total annual purchase cost, of which the purchases from related parties were RMB268.667 million, representing 5.54 % of the total annual purchase cost. Purchases from any individual supplier in excess of 50% of the total, any new supplier in top 5 suppliers or heavy dependence on a few suppliers during the Reporting Period. □Applicable √N/A 3. Expenses √Applicable □ N/A Unit: Yuan YOY Item 2022 2021 Explanations Change(%) Selling expenses 4,950,802,456.16 5,026,812,145.41 -1.51 No material change Administrative 992,483,591.51 939,253,444.33 5.67 No material change expenses Mainly due to the increase in interest income and the increase Financial expenses -352,447,424.62 -92,894,751.72 N/A in foreign exchange gains as a result of exchange rate changes during the Period. R&D expenses 1,742,088,079.94 1,397,131,273.33 24.69 No material change 4. Investment in R&D (1). Investment in R&D √Applicable □ N/A Unit: Yuan Current expensed R&D expenditure 1,583,502,138.74 Current capitalized R&D expenditure 175,159,872.18 Total R&D expenditure 1,758,662,010.92 Total amount R&D expenditure as a percentage of Revenues (%) 10.26 Ratio of capitalized R&D expenditure (%) 9.96 (2). R&D Staff √Applicable □ N/A Number of R&D staff 1,717 Proportion of R&D staff to the total employees (%) 12.20 Education background of R&D staff Education composition Number PhD 58 Postgraduate 417 Bachelor 774 Junior college graduate 350 40 Joincare Pharmaceutical Group Annual Report 2022 High school and below 118 Age composition of R&D staff Age composition Number Under 30 years old (exclusive) 842 30-40 years old (including 30 years old, excluding 40 years old) 640 40-50 years old (including 40 years old, excluding 50 years old) 187 50-60 years old (including 50 years old, excluding 60 years old) 48 Over 60 years old 0 (3). Explanations □Applicable √ N/A (4). Reasons for and impact of the material change in the composition of R&D staff personnel on future development of the Company □Applicable √ N/A 5. Cash flows √Applicable □ N/A YOY Change Item 2022 2021 Explanations (%) Mainly due to the combined effect of an increase in sales Net cash flow from 3,977,499,939.73 2,563,089,045.24 55.19 receipts and a decrease in operating activities payment of marketing expenses during the Reporting Period. Net cash flow from - -2,252,167,188.62 N/A No material change investing activities 1,964,157,731.17 Mainly due to the combined effect of new borrowing and Net cash flow from 566,327,859.36 -974,904,353.44 N/A investment absorption (through financing activities GDR issuance) during the Reporting Period. (II) Statement on material changes in profits arising from non-principal businesses √Applicable □ N/A Unit: Yuan As a percentage Sustainable or Item Amount Cause of total profit not Primarily due to changes in gains or losses Investment income 55,973,114.29 1.62% No of the associates. Gains or losses from Primarily due to fluctuations in market -76,262,989.83 -2.21% No changes in fair value value of the securities investment held. Primarily due to the impairment provision Impairment of assets -142,627,936.44 -4.13% No for inventories. Primarily due to income from disposal of scrap and transfer to non-operating income Non-operating income 8,229,847.57 0.24% No from buying on credit for longer terms and not required to be paid. Primarily due to donation expenses and Non-operating expenses 32,060,686.06 0.93% No loss on retirement of fixed assets. Primarily due to government grants Other income 289,868,006.44 8.39% Yes received. 41 Joincare Pharmaceutical Group Annual Report 2022 (III) Analysis of assets and liabilities √Applicable □ N/A 1. Status of assets and liabilities Unit: Yuan The Proportion proportion of of ending Ending ending Change in Ending balance balance of balance of balance of Item amount Explanations of this period this period previous previous (%) to the total period period to the assets (%) total assets (%) Primarily due to fluctuations in Financial assets market value of the securities 109,015,664.98 0.31 184,638,344.31 0.59 -40.96 held for trading investment held by Livzon Group, a subsidiary of the Company. Primarily due to the collection of Other receivables 52,535,740.14 0.15 88,053,825.12 0.28 -40.34 capital reduction proceeds for the period. Primarily due to the reclassification Non-current of time deposit due within one year assets due within 54,048,611.11 0.15 317,381.23 0.00 16,929.55 to non-current assets due within one one year year. Primarily due to the increase in cash Other current management businessof Livzon 163,539,900.32 0.46 83,986,214.37 0.27 94.72 assets Group, a subsidiary of the Company, for the period. Primarily due to the recovery of Long-term finance lease payments by Livzon 0.00 0.00 266,904.13 0.00 -100.00 receivables Group, a subsidiary of the Company. Primarily due to the fact that the “Recombinant SARS-CoV-2 Fusion Protein Vaccine (重组新型冠状病 毒融合蛋白疫苗)” of Livzon MAB was included in the emergency use Intangible assets 802,115,125.75 2.24 456,782,094.80 1.47 75.60 in sequential booster immunization against a novel coronavirus SARS- CoV-2 in September 2022, and the accumulated development expenditure of this project was transferred to intangible assets. Primarily due to the fact that the “Recombinant SARS-CoV-2 Fusion Protein Vaccine (重组新型冠状病 毒融合蛋白疫苗)” of Livzon MAB was included in the emergency use Development 428,284,884.17 1.20 786,993,435.71 2.53 -45.58 in sequential booster immunization expenditure against a novel coronavirus SARS- CoV-2 in September 2022, and the accumulated development expenditure of this project was transferred to intangible assets. Long-term 277,867,716.95 0.78 200,715,740.93 0.65 38.44 Primarily due to the transfer of 42 Joincare Pharmaceutical Group Annual Report 2022 prepaid expenses completion of plant decoration to long-term prepaid expenses for the period. Primarily due to the reclassification Other non- 1,156,772,182.99 3.24 663,584,003.80 2.13 74.32 of time deposit to other non-current current assets assets. Financial Primarily due to changes in fair liabilities held for 755,634.43 0.00 143,302.24 0.00 427.30 value of foreign currency forward trading contracts. Non-current Primarily due to the repayment of liabilities due 63,077,260.98 0.18 91,576,066.33 0.29 -31.12 long-term loans due within one within one year year. Primarily due to the increase in Other current expected refunds payable of Livzon 101,276,714.35 0.28 15,626,224.29 0.05 548.12 liabilities Group, a subsidiary of the Company, for the period. Primarily due to the newly incurred Long-term loans 3,230,844,042.88 9.04 826,780,252.78 2.66 290.77 long-term bank borrowings of for the period. Primarily due to the increase in Treasury shares 347,176,561.29 0.97 222,644,454.50 0.72 55.93 repurchase of shares to be cancelled. 2. Overseas assets √Applicable □ N/A (1) Asset size Of which: Overseas assets were 42.03 (Unit: 100 million Currency: RMB), representing 11.76 % of the total assets. (2) Statement on high proportion of overseas assets □Applicable √ N/A 3. Restrictions on assets entitlements as at the end of the Reporting Period √Applicable □ N/A Unit: Yuan Carrying value at the Item Cause of restriction end of the period Letters of credit, bank acceptances and forward exchange Other monetary funds 1,392,407.76 settlement deposits, etc. Notes receivable 469,659,266.19 Notes pool business and pledge of notes receivable Total 471,051,673.95 4. Others □Applicable √ N/A (IV) Analysis of industry-related business information √Applicable □N/A According to the Guidelines for the Industry Classification of Listed Companies (2012 Revision) issued by the CSRC, the Company is operating in the pharmaceutical manufacturing industry. Adhering to the mission of “For the health, For the future” and the vision of “diligently make high- quality and innovative drugs”, the Company has been committed to the pharmaceutical business 43 Joincare Pharmaceutical Group Annual Report 2022 and been strengthening R&D, production, marketing and management of medical products, to strive to become a domestic leading integrated pharmaceutical enterprise with capacity for independent innovation and international competitiveness in terms of production, technology and management in the near future. Analysis of business information on pharmaceutical manufacturing industry 1. Basic information on industry and main drugs (products) (1). Basic information on industry √Applicable □N/A I. Influence of industry policies The year of 2022 is the second year of the 14th Five-Year Plan, and the pharmaceutical industry is still magnificent, as opportunities and challenges coexist. Various key programmatic documents and policies on the pharmaceutical industry have been released, and the major policies that had a significant impact on the Company are as follows. ① Release of the 14th Five-Year Plan for the Development of the Pharmaceutical Industry In January 2022, nine departments, including the Ministry of Industry and Information Technology, the National Development and Reform Commission, jointly issued the “14th Five-Year Plan for the Development of the Pharmaceutical Industry” (the “Plan”). The Plan clarifies the development goals for the next five years: by 2025, major economic indicators will achieve medium-high growth, innovation achievements in frontier fields will be prominent, innovation driving force will be strengthened, the modernization level of industrial chain will be significantly improved, the supply and guarantee system of pharmaceutical devices will be further improved, and internationalization will be advanced in an all-round way. The Plan puts forward goals for the pharmaceutical industry in terms of scale efficiency, innovation-driven development transformation, industrial chain and supply chain, drug and equipment supply and international development, it also proposes the specific development direction of chemical pharmaceuticals, traditional Chinese medicine, biological medicine and medical device. The pharmaceutical industry is expected to enter into a new era of sustainable development. ② Routine operation of volume-based procurement In July 2022, the Notice on the Results of National Centralized Drug Procurement (GY-YD2022-1) 《关于公布全国药品集中采购(GY-YD2022- 1)中选结果的通知》 was released by the National Organization Office for Centralized Procurement of Pharmaceuticals. A total of 60 drugs were successfully procured in this round of centralized procurement, with an average price reduction of 48% for the drugs to be selected. In order to better ensure the stable supply of the drugs for centralized procurement, the mechanism of "reserve supply enterprises" was introduced in the procurement documents initially for the seventh batch of centralized drug procurement, to explore the implementation of "double supply in one province", each province not only has a selected 44 Joincare Pharmaceutical Group Annual Report 2022 enterprise, that is, the main supply enterprise, but also has a reserve supply enterprise. ③ Adjustment of the catalog of medicines covered by medical insurance In June 2022, the NHSA issued the 2022 Work Plan of the Adjustment to the Catalogue of Drugs for National Basic Medical Insurance, Work-related Injury Insurance and Maternity Insurance (《2022 年国家基本医疗保险、工伤保险和生育保险药品目录调整工作方案》) and related documents for public comments, marking commencement of a new round of adjustment work for the National Medical Insurance Catalogue. The adjustment work for the Medical Insurance Catalogue has been continuously improved and has entered the era of dynamic adjustment. While continuing to support COVID-19 treatment drugs and innovative drugs, the new medical adjustment plan issued in June 2022 fully reflects the attention to treatment drugs for rare disease and drugs for children. In September 2022, the NHSA issued the 2022 National Medical Insurance Catalogue Adjustment through Initial Review of Drugs and Information (2022 年国家医保药品目录调整通 过初步形式审查药品及信息), with 344 varieties shortlisted. ④ New Notice of reform of DRG/DIP payment method In April 2022, the NHSA issued the Notice on the Convergence of the Use of DRG/DIP Functional Module of the Payment Method Management Subsystem (《关于做好支付方式管理子系统 DRG/DIP功能模块使用衔接工作的通知》), which clarified that the NHSA had developed the basic version of the DRG/DIP functional module based on the nationally unified medical insurance information platform, and would promote the DRG/DIP payment method reform to a deeper level. According to the arrangement, the DRG/DIP functional module would be implemented and applied nationwide by the end of November 2022. ⑤ Promoting innovation in traditional Chinese medicine In March 2022, the General Office of the State Council issued the 14th Five-Year Plan for the Development of Traditional Chinese Medicine (《“十四五”中医药发展规划》) , which specifies the guiding ideology, basic principles and development goals for the development of TCM during the 14th Five-Year Plan period, proposes 10 major tasks and 11 work columns, and specific measures for each of the major tasks. By 2025, the capacity of TCM health services will be significantly enhanced, the policy and system for high-quality development of TCM will be further improved, positive results will be achieved in the revitalization and development of TCM, and its unique advantages in the construction of a healthy China will be given full play. In December 2022, the National Administration of Traditional Chinese Medicine issued the 14th Five-ear Plan for the Development of Traditional Chinese Medicine Informatization (《“十四五” 中医药信息化发展规划》), which clearly proposed the construction of TCM internet hospitals, the development of telemedicine and internet diagnosis and treatment, and providing support for the construction of intelligent hospitals in about 20 Class III TCM hospitals. Meanwhile, governments at various levels actively support the development of TCM informatization through existing funding 45 Joincare Pharmaceutical Group Annual Report 2022 channels, and through guiding social investment to increase investment in TCM informatization and statistics. ⑥ In-depth reform of medical and healthcare system In May 2022, the General Office of the State Council issued the Key Tasks for Deepening the Reform of the Medical and Health System in 2022 (《深化医药卫生体制改革2022年重点工作任 务》)(the "Tasks"), which put forward 21 key tasks from 4 aspects covering accelerating the construction of a new pattern of orderly access to medical diagnosis and treatment, deeply promoting the experience of Sanming's medical reform, making efforts to enhance the capacity of public health services, and promoting the high-quality development of medicine and health. The general requirements of the Tasks are to comprehensively promote the construction of a healthy China, deeply promote the experience of Sanming's medical reform, promote the expansion and balanced layout of high-quality medical resources, deepen the linkage reform of medical care, medical insurance and medicine, continuously promote the shift from focusing on the treatment to focusing on people's health, and continuously promote to solve the difficult problems of the lack of accessibililty to and the high costs of medical treatment. For the pharmaceutical industry, new requirements for development at stages have also been put forward. ⑦ Market exclusivity of new drugs for rare diseases In May 2022, the NMPA conducted a study on the Implementation Rules of the Law of the PRC on the Administration of Drugs (《中华人民共和国药品管理法实施条例》),forming an amended consultation draft for public comments (the “Consultation Draft"). The Consultation Draft proposes for the first time to grant a period of market exclusivity to new drugs such as drugs for rare diseases. The Consultation Draft proposes that the state encourages the development and innovation of drugs for rare diseases, supports the development of drugs for rare diseases by the holders of drug marketing licenses, encourages the development of launched drugs for new indications of rare diseases, and gives priority to the review and approval of drugs for rare diseases that are in urgent clinical need. During drug development and registration filing, communication with sponsors will be strengthened to facilitate the speedy launch of drugs for rare diseases and meet the clinical needs of patients with rare diseases. For new drugs approved for marketing for rare diseases, a period of market exclusivity of up to seven years will be granted under the commitment of the drug's marketing licensee to safeguard the supply of the drug, during which time the same variety will not be approved for marketing. Response measures: The Company will take effective measures to cope with major changes in policies of the pharmaceutical industry through early layout, transformation, and compliance, and constantly improve its core competitive strength. Meanwhile, the Company will actively increase the research, development and innovation of new products, drive development through R&D, continuously optimize and adjust the product structure, strenuously apply for medical insurance 46 Joincare Pharmaceutical Group Annual Report 2022 coverage, and maintain the competitive sales of large varieties while keeping striving for market access and promoting sales to lower-tier markets. The Company will create more competitive advantages of products, improve the production quality management, standardize the safe and environmentally friendly production, operate in compliance with regulations, and establish a more reasonable market-oriented system in order to establish its own advantageous position and core competitiveness. II. Basic information on the sector where the Company operates The Company is primarily engaged in the R&D, production and sale of hundreds of varieties of pharmaceutical products and health care products in areas such as chemical pharmaceuticals, biologics, chemical active pharmaceutical ingredients (APIs), TCM, and health care products. Basic information on the market niches in which the Company operates are follows: Chemical pharmaceuticals: In recent years, influenced by policies regarding medical insurance payment control, volume-based procurement and consistency evaluation, chemical pharmaceuticals have recorded a slower growth in revenues and profit. The market of chemical pharmaceuticals is relatively competitive as there are many domestic manufacturers. However, innovative drugs and high-barrier formulations will become an industry trend and an important source of profits thanks to low competitive pressure and continuous support from national policies. The Company's chemical pharmaceuticals cover many therapeutic fields with competitive strengths in product varieties, sales channels, end user groups and brand awareness. In the future, the Company will speed up research and development, introduce new technologies, and accelerate the product structure optimization and strategic planning to cope with the increasingly fierce market competition. Biologics: Biologics include monoclonal antibodies, vaccines, recombinant therapeutic proteins and other biological therapies. Globally, the development of biologics has been relatively late compared to chemical pharmaceuticals products, and it is only in the last 40 years that they have entered the large-scale industrialization stage. However, due to the safety, efficacy, and other clinical needs met by biologics that chemical pharmaceuticals could not satisfy, the biologics industry has grown rapidly in recent years, especially in emerging markets such as China, where the biologics industry is growing at a much faster rate than the general pharmaceutical industry. China's biologics market is still in a period of unstable segment structure, continued increase in unmet clinical needs, more frequent technology iteration, and rapid growth of emerging segments such as monoclonal antibodies. LivzonBio is the primary biopharmaceutical R&D platform of the Company and principally engages in the independent innovative R&D and commercialization of biopharmaceuticals, including innovative mAbs (monoclonal antibodies), mAb biosimilars, bispecific antibodies, antibody drug conjugates, CAR-T cell therapies, etc., with its products covering multiple fields such as tumor, autoimmune disease, vaccine, etc. Chemical APIs: At present, the Company has the following chemical APIs: cephalosporin series, 47 Joincare Pharmaceutical Group Annual Report 2022 statin series, and carbapenem series among others. Restricted by heavy investment, long construction period, high technical threshold and strict environmental protection requirements, the bulk API market in China is relatively concentrated. However, overcapacity causes fierce competition. To adapt to future competition, the Company gradually completed the transformation and upgrading from bulk APIs to high-end characteristic APIs, from nonstandard market to standardized market and from domestic market to international market. Meanwhile, in an effort to further implement the Implementation Plan to Promote the High-quality Development of the API Industry issued by the National Development and Reform Commission and the Ministry of Industry and Information Technology in November 2021, the Company strengthened forward-looking research layout to accelerate high-quality development of APIs under new background. Since October 2020, the Company has focused on building a research and development platform in synthetic biology with AI integrated to promote green, low-carbon transformation of the industry, to give more added value to pharmaceutical intermediates and APIs, and to accelerate integration into the global industrial chain and value chain. TCM: In recent years, encouraged by many favorable national policies, the TCM industry has gained abundant opportunities to grow. Since 2021, the state has successively issued several policies, including the Several Policies and Measures on Accelerating the Characteristic Development of Traditional Chinese Medicine, the Notice on Updating the Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine (Covered by Medical Insurance) and the14th Five-Year Plan for the Development of Traditional Chinese Medicine. These policies emphasize the need to optimize the TCM evaluation and approval management, to improve the classification and registration management, to implement suitable payment policies, to strengthen the price management, to adopt integrative medicine approach, and to promote the development of TCM industry. In the fight against the epidemic, ‘three drugs and three prescriptions’ of TCM play an important role in clinic treatment, highlighting the importance of TCM. Shenqi Fuzheng Injection, Anti-Viral Granules and other products from Livzon Group, a holding subsidiary of the Company, are representatives of the Company's TCM products. In the future, the Company will continue to intensify R&D and technological innovation to drive sustainable profitability. Diagnostic reagents and equipment: As China's healthcare industry develops gradually, in vitro diagnostic reagents industry is seeing a bigger market but remains in primary stage compared with developed countries such as European countries and America. With more product varieties and more advanced technologies, in vitro diagnostic reagents are used in more scenarios, from traditional hospital laboratories to third-party medical diagnostic institutions, physical examination centers, families, and other primary healthcare institutions. More application scenarios make the demand for different kinds of in vitro diagnostic reagents fully released, promoting rapid development of the industry. Since its establishment, Livzon Diagnostics, controlled by Livzon Group (a holding subsidiary of the Company), has been committed to the R&D, production and sales of diagnostic reagents and equipment. After years of efforts and development, it has built a multi-faceted technical 48 Joincare Pharmaceutical Group Annual Report 2022 platform that supports ELISA test, colloidal gold rapid test, chemiluminescence assay, multiplex liquid-chip assay, and nucleic acid assay. It has strong market influence in such fields as respiratory infection, infectious diseases, and drug concentration monitoring. Some of its products hold big market shares in China. Health care products: Driven by increasing public awareness of wellness, aging, consumption upgrading and promotion of direct sales, health care industry has developed rapidly in recent years. However, due to low technical threshold and high gross profit, the domestic market is highly competitive with serious product homogeneity issues and low market concentration. The Company’s well-known health care foods brands such as “Taita” (太太),“ Jingxin” (静心) and “Eagle's” (鹰牌) deeply rooted in people's minds and have high market awareness. Faced with intense market competition, while staying committed to traditional pharmaceutical chain channels, the Company also actively expands online channels through strategic cooperation with new social e-commerce sales platforms to drive sales growth. In addition, the Company actively prepares to access to fields of functional food by leveraging its R&D and market strengths to enrich product pipelines and enhance core competitiveness. (2). Basic information on main drugs (products) √Applicable □N/A Basic information on main drugs (products) by segment and therapeutic areas √Applicable □N/A Included New drug Effective and in the (product) Protected expiration Catalog Included Main Name of launched Registration Prescription TCM date of patent of in Segment therapeutic drug Indications during the Category drug or not or not (if right for National NRDL area (product) Reporting applicable) invention (if Essential or not Period or applicable) Drugs or not not From 23 Ilaprazole Chemical Chemical Peptic ulcer October Gastroenterology Sodium for drugs Class Yes No No No No pharmaceuticals bleeding 2009 to 23 Injection 2 October 2029 From 23 Leuprorelin Endometriosis, Chemical December Chemical Gonadotropic Acetate hysteromyoma, drugs Class Yes No 2010 to 23 No No Yes pharmaceuticals hormones Microspheres breast cancer, 6 December for Injection etc. 2030 Ilaprazole From 24 Chemical Duodenal ulcer Chemical Enteric- March 2006 to Gastroenterology drugs and reflux Yes No No No Yes pharmaceuticals Coated 24 March Class 1.1 esophagitis Tablets 2026 Used to treat infection caused From 6 June Chemical by one 2006 to 6 June Chemical Meropenem Anti-infection drugs Class bacterium Yes No 2026 From 31 No No Yes pharmaceuticals for Injection 4 or more bacteria July 2012 to sensitive to 31 July 2032 meropenem. Note: The starting and expiration dates listed above refer to the corresponding term of patents of core products in each product category. 49 Joincare Pharmaceutical Group Annual Report 2022 Main drugs (products) newly added into and exited from the National Reimbursement Drug List during the Reporting Period √Applicable □N/A Catalog of National Essential National Reimbursement Drug Name of main products Drugs List Ilaprazole Sodium for Injection Not included Included Leuprorelin Acetate Microspheres Not included Included for Injection Ilaprazole Enteric-Coated Tablets Not included Included Meropenem for Injection Not included Included Winning bids for main drugs in centralized drug procurement during the Reporting Period √Applicable □N/A Total actual procurement Name of main drugs Bid-winning price range volume by Unit medical institutions Ilaprazole Sodium for Injection RMB71.00 1,697.62 Ten thousand boxes Leuprorelin Acetate Microspheres for RMB1,272.58-1,275.90 153.70 Ten thousand ampules Injection Ilaprazole Enteric-Coated Tablets (6 tablets) RMB78.34-99.58 1,490.93 Ten thousand boxes Ilaprazole Enteric-Coated Tablets (10 tablets) RMB156.30-158.12 118.60 Ten thousand boxes Meropenem for Injection 0.25g RMB6.30-54.66 638.23 Ten thousand ampules Meropenem for Injection 0.5g RMB10.71-86.53 1,178.07 Ten thousand ampules Meropenem for Injection 1g RMB18.21-167 73.49 Ten thousand ampules Explanations √Applicable □N/A ① Data regarding total actual procurement volume by medical institutions are from IQVIA; ② The information disclosed is the bid-winning price of the issuer province and newly implemented winning prices during the Reporting Period. ③ Meropenem for Injection was included in the seventh batch of national volume-based drug procurement in July 2022, with a significant price adjustment. Operating data by therapeutic areas or main drug (products) √Applicable □N/A Unit: 10,000 Yuan Currency: RMB YoY YoY YoY Gross profit Gross change change change margin of Operating Operating profit in in gross Therapeutic area in products in the income costs margin operating profit operating same field in the (%) income margin costs (%) same industry (%) (%) Gastroenterology 343,589.84 47,011.06 86.32 -6.48 5.00 -1.50 79.23 Gonadotropic 259,068.36 82,191.10 68.27 5.64 -4.66 3.43 - hormones Anti-infection 130,468.34 24,765.24 81.02 -16.44 -2.24 -2.76 58.39 Respiratory 117,364.29 20,014.56 82.95 103.37 87.69 1.43 84.95 Psychiatry 54,484.55 2,845.42 94.78 32.19 44.07 -0.43 82.92 50 Joincare Pharmaceutical Group Annual Report 2022 Explanations √Applicable □N/A ① The gross profit margin of products in the field of gastroenterology is derived from that of the relevant industry in “Major products of metabolism and alimentary system” in Fosun Pharma's 2021 Annual Report. ② No comparable data on gross profit margin in the field of gonadotropic hormones has been found. ③ The data on the gross profit margin of products in the field of anti-infection comes from that of “anti-infection category” in the 2021 Annual Report of Tianyao Co., Ltd. ④ The gross profit margin data of products in the field of the respiratory comes from that of “respiratory system category” in Luoxin Pharmaceutical's 2021 Annual Report. ⑤ The gross profit margin data of products in the psychiatric field comes from that of “psychiatric category” in Nhwa Pharmaceutical 's 2021 Annual Report. 2. Drug (product) R&D of the Company (1). Overview of R&D of the Company √Applicable □N/A (1)Chemical pharmaceuticals ① High-barrier complex formulations: There were a total of 45 projects under research, of which, 4 had been launched to the market, 6 had been applied for production, 11 were under the clinical/BE study and 2 received clinical trial approvals. The progress of the major projects was as follows: Inhalation formulations: Terbutaline Sulfate Nebulizer Solution (硫酸特布他林雾化吸入用溶 液) and Levosalbutamol Hydrochloride Nebulizer Solution (盐酸左沙丁胺醇雾化吸入溶液) (3ml:1.25mg), Acetylcysteine solution for inhalation(吸入用乙酰半胱氨酸溶液) and Tobramycin Inhalation Solution (妥布霉素吸入溶液) had been launched for market. Fluticasone Propionate Inhalation Suspension (丙酸氟替卡松雾化吸入用混悬液) had been applied for production; The clinical trial of Indacaterol Maleate Powder for Inhalation (马来酸茚达特罗吸入粉雾剂) had been completed and the drug had been applied for production; The registration application of Salmeterol Xinafoate -Fluticasone Propionate Powder for Inhalation (沙美特罗替卡松吸入粉雾剂) was submitted after the completed PK-BE study, the notice of clinical trial approval was received, and the phase III clinical study was quickly started; Phase I clinical trials of Levosalbutamol Hydrochloride and Ipratropium Bromide Inhalation Solution (盐酸左沙丁胺醇异丙托吸入溶液) and Formoterol Fumarate Inhalation Aerosol (富马酸福莫特罗吸入气雾剂) were completed; For class 2 new drug XYP-001, the Company had received the notice of the clinical trial approval and started phase I clinical trials; Sustained-release microspheres: The project of Triptorelin Acetate Microspheres for Injection (注 射 用 醋 酸 曲 普 瑞 林 微 球 ) (1-month sustained release) for treatment of prostate cancer had completed all registration verification, GMP compliance checks, the first registration inspection, 51 Joincare Pharmaceutical Group Annual Report 2022 and the supplementary data studywhich was submitted to CDE; the project of Triptorelin Acetate Microspheres for Injection (注射用醋酸曲普瑞林微球) (1-month sustained release) for treatment of endometriosis has completed patient enrollment, the follow-up period close to end; Aripiprazole Microspheres for Injection (注射用阿立哌唑微球) (1-month sustained release) completed phase I multiple-dosing clinical trial; Octreotide Acetate Microspheres for Injection (注射用醋酸奥曲肽 微球) (1-month sustained release) and Leuprorelin Acetate Microspheres for Injection (注射用醋 酸亮丙瑞林微球) (3-month sustained release) were undergoing BE trials; Alarelin Microspheres for Injection (注射用丙氨瑞林微球) (1-month sustained release) was undergoing phase I clinical trial; Triptorelin Pamoate Microspheres for Injection (注射用双羟萘酸曲普瑞林微球) (3-month sustained release) was in phase I clinical trial; Triptorelin microspheres of dihydroxynaphthoate for injection (3-month sustained release) was prepared for phase I clinical trial; Goserelin Acetate Sustained-release Implant (醋酸戈舍瑞林缓释植入剂) (1-month sustained-release) had carried out the bridging study of pilot-scale and full-scale production. ②Conventional formulations: There were a total of 42 projects under research, of which, 6 projects had applied for production, 5 projects were under the clinical/BE study and 3 projects received clinical trial approval. The progress of the major projects was as follows: New indications of Ilaprazole Sodium for injection (注射用艾普拉唑钠), Blonanserin Tablets(布南色林片) and Lurasidone Hydrochloride Tablets (盐酸鲁拉西酮片) had been applied for production; LZ001 and Ilaprazole Enteric-coated Tablets(艾普拉唑微丸肠溶片) have been approved for phase I clinical trials; and Progesterone Injection(黄体酮注射液) was undergoing BE trial. ③Consistency evaluation: There were a total of 16 projects under research, of which, 6 projects have been approved for launching and 3 projects applied for review. 6 varieties such as Clarithromycin Tablets(克拉霉素片), Valsartan Capsules(缬沙坦胶囊), and Cefodizime Sodium for Injection (注射用头孢地嗪钠) had been approved for launching; Supplemental information had been submitted for Imipenem and Cilastatin Sodium( 亚 胺 培 南 西 司 他 丁 钠 ), Cyclosporine Softgels(环孢素软胶囊) (50 mg), Vancomycin Hydrochloride for Injection and Bismuth Potassium Citrate Capsule (枸橼酸铋钾胶囊). (2)Biologics There were a total of 8 projects under research, of which, 1 was approved for launching, 1 in the conditional marketing application stage; 1 in the marketing application (BLA) stage (approved for marketing in January 2023), 1 in the phase III clinical trial, 2 in the phase Ib or phase II clinical trial and 2 in the phase I clinical trial. Therapeutic biological products: Recombinant Human Choriogonadotropin Alfa for injection was approved for launching in China in 2021 and overseas registration is underway; the BLA application of Tocilizumab injection (托珠单抗注射液) has been accepted by CDE and approved for launching in China in January 2023; phase II clinical trials of Recombinant Anti-human IL-17A/F Humanized 52 Joincare Pharmaceutical Group Annual Report 2022 Monoclonal Antibody for Injection (重组抗人 IL-17A/F 人源化单克隆抗体注射液)were completed; Recombinant Humanized Anti-PD-1 Monoclonal Antibody for Injection (注射用重组人源化抗 PD-1 单 克 隆 抗 体 ) is undergoing phase Ib/II clinical trials; Recombinant Human Follicle Stimulating Hormone for Injection (重组人促卵泡激素注射液) completed Phase I clinical trials; and Recombinant Tumor Enzyme Specific Interferon α-2bFc Fusion Protein for Injection (注射用重组肿瘤酶特异性干 扰素 α-2bFc 融合蛋白) was undergoing phase I clinical trials. The diabetic drug Semaglutide injection (司美格鲁肽注射液) was approved for clinical trials, and the first phase III clinical center was launched in December 2022. Preventive biological products: The Recombinant SARS-CoV-2 Fusion Protein Vaccine (Likang V-01) was approved for emergency use in domestic heterologous booster vaccination in June 2022, and was included in the national immunization program in September 2022. Meanwhile, a conditional marketing application of such vaccine had been submitted to the NMPA, which was under review. (3)APIs and intermediates There were a total of 39 projects under research, of which 23 were new product R&D projects and 16 were tech-upgradation projects of existing products. For new product R&D projects, the API of Fluticasone Furoate ( 糠 酸 氟 替 卡 松 ) had been approved for launching, and the registration application for the API of Biapenem(比阿培南) and the API of Caspofungin Acetate (醋酸卡泊芬 净)were submitted. For technological upgrading projects of existing products, the key project Cephalosporin C-High Producing Mutant Strains (头孢菌素 C 高产突变株) was progressing smoothly. After screening, the scale production verification of the strains had been completed, and the average unit yield had been steadily increased; in the development and selection project of new L-phenylalanine – High Producing Strains (L-苯丙氨酸新型高产菌株) driven by IBT technology, high-value natural product chassis strains such as L-phenylalanine, L-tyrosine and shikimic acid had been screened, strain modification and selection was proceeding and shake-flask cultivation has achieved initial results. (4)Traditional Chinese medicine There were 8 projects under research for new TCM, of which, SXSHL gel, a new improved traditional Chinese medicine, had completed pre-clinical trial experiment research, and its application materials were being prepared and collected. The single-center clinical trial of in- hospital preparations was completed for TGDX Granules, a class 1.1 new traditional Chinese medicine, and initial draft of the clinical trial summary report was obtained. (5)Diagnostic reagents and equipment There were 86 projects under research, of which, 1 was in the clinical stage (including evaluation); there were a total of 15 technological upgradation projects, including 7 projects were filed for change of registration. In March 2022, Livzon Diagnostics actively responded to the national pandemic prevention and control policy, and promptly initiated the registration of Livzon Rapid Test for 2019-nCoV Antigen 53 Joincare Pharmaceutical Group Annual Report 2022 (Lateral Flow) (新型冠状病毒 (2019-nCoV)抗原检测试剂盒(乳胶法)), which was successfully approved for launching on April 9, 2022. Diagnostic Kit for Immunoglobulin G4 (Chemiluminescence Immunoassay) (免疫球蛋白 G4 测定试剂盒(化学发光法)) and its supporting calibrators and quality control products obtained registration certificates in June 2022; mycoplasma pneumoniae IgM antibody detection kit (chemiluminescence) and four diabetes specific autoantibodies were registered successively in November 2022; three items of chromatography platform blood type card were registered in August 2022. In addition, 6 projects, including Livzon Rapid Test for 2019-nCoV Antigen (Lateral Flow) (新型 冠状病毒(2019-nCoV)抗原检测试剂盒(乳胶法)) and Nucleic Acid Test Kit for Monkeypox Virus (Real-time PCR) ( 猴 痘 病 毒 核 酸 检 测 试 剂 盒 (PCR- 荧 光 探 针 法 )), and full automated chemiluminescence analyzer successively obtained CE certificates. (2). Basic information on main R&D projects √Applicable □N/A Protected R&D projects Name of drug Registration Prescription TCM or not R&D stage (including projects Indications (product) Category drug or not (if (registration) subject to GCE) applicable) It is suitable for maintenance therapy of bronchiectasis to Indacaterol Maleate Indacaterol Maleate Chemical relieve symptoms in adults with Application Powder for Powder for drugs Class chronic obstructive pulmonary Yes No for Inhalation Inhalation 4 disease (COPD), including registration chronic bronchitis and emphysema. Fluticasone Fluticasone Chemical Application Propionate Propionate Treatment of moderate and drugs Class Yes No for Inhalation Inhalation severe persistent asthma. 4 registration Suspension Suspension Suitable for the maintenance treatment of bronchoconstriction Formoterol Formoterol Chemical Application in patients with chronic Fumarate Inhalation Fumarate Inhalation drugs Class Yes No for obstructive pulmonary disease Solution Solution 3 registration (COPD), including chronic bronchitis and emphysema. In combination (bronchodilators Salmeterol Salmeterol and inhaled corticosteroids) for Xinafoate and Xinafoate and Chemical the regular treatment of Fluticasone Fluticasone drugs Class Yes No Clinical trial reversible obstructive airways Propionate Powder Propionate Powder 4 disease, including asthma in for Inhalation for Inhalation adults and children. Chemical drugs Class For the treatment of Idiopathic XYP-001 XYP-001 Yes No Clinical trial 2.2; Class pulmonary fibrosis (IPF) 2.4 Mometasone Mometasone Furoate and Furoate and Chemical Suitable for bronchial asthma Formoterol Formoterol drugs Class and chronic obstructive Yes No Clinical trial Fumarate Dihydrate Fumarate Dihydrate 3 pulmonary disease. Inhalation Aerosol Inhalation Aerosol 54 Joincare Pharmaceutical Group Annual Report 2022 Formoterol Formoterol Chemical Suitable for bronchial asthma Fumarate Inhalation Fumarate drugs Class and chronic obstructive Yes No Clinical trial Aerosol Inhalation Aerosol 2.2 pulmonary disease. Recombinant Novel Preventive Coronavirus Fusion biological Prevention of diseases caused by Launched V-01(COVID-19) Yes No Protein Vaccine product novel coronavirus infection under EUA (Class 1.1) Recombinant Humanized Anti- Therapeutic Application LZM009(PD-1) PD-1 Monoclonal biological Advanced solid tumors Yes No for Antibody For product registration Injection Triptorelin acetate Metastatic prostate cancer, sustained-release Triptorelin Acetate Chemical endometriosis (stage I to IV), Application microspheres for Microspheres for drugs Class female infertility, preoperative Yes No for injection (1 month Injection 2.2 treatment of uterine fibroids, registration release) precocious puberty Recombinant Anti- Human IL-17A/F Therapeutic LZM012 ( IL- Humanized biological Moderate to severe plaque Yes No Clinical trial 17A/F) Monoclonal product psoriasis Antibody for (Class 1) Injection Chemical Application Blonanserin Blonanserin drugs Class Schizophrenia Yes No for 4 registration (3). Drugs (products) filed for regulatory approval and granted approval during the Reporting Period √Applicable □N/A ① Drugs (products) filed for regulatory approval during the Reporting Period Registration Name of drug Approval items Indications Category Fluticasone Propionate Chemical Application for Treatment of mild to moderate acute asthma attacks in Nebulized Suspension drugs Class 4 registration children and adolescents aged 4-16 years. This product is a bronchodilator suitable for maintenance Indacaterol maleate Chemical Application for treatment of adult patients with chronic obstructive inhalation powder drugs Class 4 registration pulmonary disease (COPD). Triptorelin Acetate Chemical Microspheres for Application for drugs Class Prevent stress ulcer bleeding in severe patients. Injection (new registration 2.4 indications) Chemical Application for Blonanserin Tablets Schizophrenia. drugs Class 4 registration Lurasidone Hydrochloride Chemical Application for Schizophrenia. Tablets drugs Class 4 registration Used for routine treatment of reversible obstructive Salmeterol Xinafoate and Chemical Application for airway diseases through combination of drugs Fluticasone Propionate drugs Class 4 Clinical trials (bronchodilators and inhaled corticosteroids), including Powder for Inhalation asthma in adults and children. 55 Joincare Pharmaceutical Group Annual Report 2022 Chemical Application for XYP-001 drugs Class Temporarily used for idiopathic pulmonary fibrosis Clinical trials 2.2 and 2.4 Recombinant Novel Coronavirus Fusion Preventive Protein Bivalent Biological Application for Used for treatment of novel coronavirus infection (prototype strain/Omicron products Clinical trial (COVID-19). strain) Vaccine (CHO Class 1.1 cells) Chemical Application for Luteal function supplementation in infertile women Progesterone Injection drugs Class 3 Clinical trials undergoing assisted reproductive technology. 1. Treat duodenal ulcer and reflux esophagitis.2. Treatment of duodenal ulcer and reflux esophagitis in Chemical Ilaprazole enteric-coated Application for children (12-17 years old).3. Treat non-erosive drugs Class pellets Clinical trials gastroesophageal reflux disease.4. Treat gastric ulcer.5. 2.2 and 2.4 Eradication of helicobacter pylori.6. Prevent gastric ulcer caused by non-steroidal anti-inflammatory drugs. Chemical Application for Treatment of schizophrenia in adults; treatment of manic Asenapine patch drugs Class Clinical trials or mixed episodes of bipolar I disorder. 2.2 Bismuth potassium citrate Chemical Supplemental Used for chronic gastritis and relieving stomach pain, capsules (under drugs application heartburn and acid regurgitation caused by hyperacidity. consistency evaluation) Intravenous infusion of this product is indicated for infections caused by methicillin-resistant staphylococcus aureus and other bacteria: septicemia, infective endocarditis, osteomyelitis, arthritis, burns, surgical Vancomycin trauma and other superficial secondary infections, Chemical Hydrochloride for Supplemental pneumonia, lung abscess, empyema, peritonitis and drugs injection (under application meningitis. It may be administered orally for antibiotic- consistency evaluation) associated pseudomembranous colitis due to clostridium difficile and staphylococcal enterocolitis, while administration by injection has not been shown to be effective for either indication. Oral vancomycin is not effective for other types of infections. 1. Duodenal ulcer. 2.Stomach ulcer. 3.Moderate and Pantoprazole sodium for Chemical Supplemental severe reflux esophagitis. 4.Acute upper gastrointestinal injection (consistency drugs application bleeding caused by duodenal ulcer, gastric ulcer, acute evaluation) gastric mucosal lesion, compound gastric ulcer, etc. ② Drugs (products) granted clinical approval during the Reporting Period Registration Name of drug Indications Category Salmeterol Xinafoate Chemical drugs Asthma: In combination (bronchodilators and inhaled and Fluticasone Class 4 corticosteroids) for the regular treatment of reversible 56 Joincare Pharmaceutical Group Annual Report 2022 Propionate Powder for obstructive airways disease, including asthma in adults and Inhalation children. Chemical drugs XYP-001 Treatment of idiopathic pulmonary fibrosis (tentative) Class 2.2 and 2.4 Therapeutic biological Semaglutide Injection Type II diabetes products Class 3.3 Chemical drugs Advanced solid tumours carrying NTRK1/2/3, ROS1 or ALK LZ001 Class 1 gene fusions 1. treat duodenal ulcer and reflux esophagitis.2. treatment of duodenal ulcer and reflux esophagitis in children (12-17 years Ilaprazole enteric-coated Chemical drugs old).3. Treat non-erosive gastroesophageal reflux disease.4. pellets Class 2.2 and 2.4 treat gastric ulcer.5. eradication of helicobacter pylori. 6. prevent gastric ulcer caused by non-steroidal anti- inflammatory drugs. Chemical drugs Luteal function supplementation in infertile women Progesterone injection Class 3 undergoing assisted reproductive technology. ③ Drugs (products) granted registration approval during the Reporting Period Registration Name of drug Indications classification Levosalbutamol Used for treating respiratory diseases such as bronchial asthma Hydrochloride Nebuliser Supplemental or asthmatic bronchitis accompanied by bronchospasm in Solution application children. (3ml:1.25mg) Terbutaline sulfate Chemical drugs Relieves bronchospasm associated with bronchial asthma, solution for nebulized Class 4 chronic bronchitis, emphysema and other lung diseases. inhalation Used for the treatment of respiratory diseases with excessive Acetylcysteine solution Chemical drugs secretion of thick mucus, such as acute bronchitis, chronic for inhalation Class 4 bronchitis and its exacerbation, emphysema, mucoviscidosis, and bronchiectasis It is indicated for bronchiectasis in adults with pulmonary Tobramycin Solution for Chemical drugs Pseudomonas aeruginosa infection to control infection and Inhalation Class 2.4 improve symptoms. Ilaprazole Sodium for Injection (Application in NDA Peptic ulcer bleeding Indonesia) Preventive Recombinant SARS- biological CoV-2 Fusion Protein Prevention of novel coronavirus infection products Vaccine (EUA) Class 1.1 Clarithromycin is indicated for the treatment of infections caused by pathogens sensitive to clarithromycin, including: 1.Lower respiratory tract infection (bronchitis, pneumonia) Clarithromycin Tablets Chemical drugs 2.Upper respiratory tract infection (pharyngitis, sinusitis) (consistency evaluation) 3.Skin and soft tissue infections (folliculitis, cellulitis, erysipelas) 4.Local or disseminated infection 5.Mixed infection 6.Eradication of Helicobacter pylori 7.Dental infection Valsartan Capsules (consistency Chemical drugs Used for treatment of mild to moderate essential hypertension. evaluation) Long-term treatment of coronary heart disease; prevention of Isosorbide Mononitrate angina pectoris; treatment of persistent angina pectoris after Tablets (consistency Chemical drugs myocardial infarction; treatment of chronic congestive heart evaluation) failure in combination with digitalis and/or diuretics. 57 Joincare Pharmaceutical Group Annual Report 2022 This product is indicated for cefodizine-sensitive streptococcus, streptococcus pneumoniae, neisseria gonorrhoeae, branhamella catarrhalis, escherichia coli, Cefodizime sodium for citrobacter, klebsiella, enterobacter, serratia, roteus, morganella injection (consistency Chemical drugs morganii, providencia, haemophilus influenzae, evaluation) peptostreptococcus, bacteroides, the infections caused by prevotella including upper urinary tract infection, lower urinary tract infection, lower respiratory tract infection and gonorrhea. It is indicated for the following conditions caused by sensitive bacteria: 1.Respiratory tract infection; 2.Ear, nose and throat infections; Cefuroxime sodium for 3.Urinary tract infection; injection (consistency Chemical drugs 4.Skin and soft tissue infections; evaluation) 5.Bone and joint infections; 6.Obstetric and gynaecological infections; 7.Gonorrhea; 8. Other infections; 1.Duodenal ulcer. 2.Stomach ulcer. Pantoprazole sodium for 3.Moderate and severe reflux esophagitis. injection (consistency Chemical drugs 4.Acute upper gastrointestinal bleeding caused by duodenal evaluation) ulcer, gastric ulcer, acute gastric mucosal lesion, compound gastric ulcer, etc. (4). Cancellation of main R&D projects or the failure to obtain approval for drugs (products) during the Reporting Period □Applicable √N/A (5). R&D accounting policy √Applicable □N/A Expenditures on an internal research and development project are classified into expenditures on the research phase and expenditures on the development phase. Expenditures on the research phase shall be recognized in profit or loss for the current period when incurred. Expenditures on the development phase will be capitalized only when all of the following conditions are satisfied: it is technically feasible to finish the development of the intangible asset so that it will be available for use or sale; the Company intends to finish the development of the intangible asset and use or sell it; it can be demonstrated how the intangible asset will generate economic benefits, including proving that the intangible assets or the products produced by it will have markets, or the intangible assets for internal use will be useful; there are adequate technical, financial and other resources to complete the development and the Company is able to use or sell the intangible assets; and expenditures on the development phase attributable to the intangible assets can be reliably measured. The development expenditures that do not satisfy the above conditions shall be recognized in profit or loss for the current period. 58 Joincare Pharmaceutical Group Annual Report 2022 Our research and development projects enter the development stage after meeting the above conditions and forming the project through the technical and economic feasibility studies. Capitalized expenditures on the development phase are shown as development expenditures on the balance sheet and reclassified as intangible assets on the date the project meets the intended purpose. Capitalization conditions for specific research and development projects are as follows: ① For research and development projects that are not required to obtain clinical approvals, the period from the beginning of research and development to before the pilot phase is treated as the research phase, and all expenditures shall be recognized in profit or loss for the current period when incurred; the period from the pilot phase to the obtaining of production approvals is treated as the development phase, and all expenditures shall be recognized as development expenditures and reclassified as intangible assets after the obtaining of production approvals. ② For research and development projects that require clinical approval, the period from the beginning of research and development to the obtaining of clinical approval is treated as the research phase, and all expenditures incurred shall be recognized in profit or loss for the current period when incurred; the period from the obtaining of clinical approval to the obtaining of production approval is treated as the development phase, and the expenditures shall be recognized as development expenditures and reclassified as intangible assets after the obtaining of production approval. ③External technology transfer fees and the cost of purchasing clinical approvals can be recognized directly as development expenditures, and subsequent expenditures are accounted for in accordance with ① and ② above. ④The Company reviews the latest research and development status of each project at the end of each year and if the research and development project no longer qualifies for the development stage, the corresponding development expenditure are recognized in profit or loss for the current period. ⑤Where it is impossible to differentiate the expenditures on the research phase and the expenditures on the development phase, all the research and development expenditures are recognized in profit or loss for the current period. (6). R&D expenditures Horizontal comparison √Applicable □N/A Unit: 10,000 Yuan Currency: RMB Proportion of Ratio of Proportion of R&D capitalized R&D Comparable peer R&D R&D expenditures amount expenditures to expenditures companies expenditures to revenues (%) (%) net assets (%) Fosun Pharma 497,500.00 12.75 10.28 22.93 59 Joincare Pharmaceutical Group Annual Report 2022 Kelun Pharma 179,953.47 10.42 12.99 3.50 CR Double-Crane 63,974.38 7.02 6.11 35.98 Humanwell Healthcare 106,053.87 5.16 8.19 23.58 (Group) North China 50,467.67 4.86 8.29 74.85 Pharmaceutical Average R&D expenditures in the same industry 179,589.88 Proportion of R&D expenditures to revenues during 10.26 the Reporting Period (%) Proportion of R&D expenditures to net assets during 7.99 the Reporting Period (%) Ratio of capitalized R&D expenditures during the 9.96 Reporting Period (%) Notes: 1. The data regarding comparable companies listed above are from each company's 2021 annual report; 2. The average R&D expenditures in the same industry is the arithmetic average of the R&D expenditures of five comparable companies listed above. Statement on material changes in R&D expenditures and rationality of R&D expenditures proportion and capitalization proportion √Applicable □N/A Mainly due to the fact that the “Recombinant SARS-CoV-2 Fusion Protein Vaccine (重组新型冠 状病毒融合蛋白疫苗)” of Livzon MAB was included in the emergency use in sequential booster immunization against a novel coronavirus SARSCoV-2 in September 2022, and the accumulated development expenditure of this project was transferred to intangible assets. Investment in major R&D projects √Applicable □N/A Unit: 10,000 Yuan Currency: RMB Proportion of R&D Expensed Capitalized R&D YoY R&D project expenditures R&D R&D expenditures to change (%) amount expenditures expenditures revenues (%) Indacaterol Maleate 1,318.71 0.02 1,318.69 0.08 206.37 Powder for Inhalation Fluticasone Propionate 646.40 646.40 - 0.04 -32.98 Nebulizable Suspension Formoterol Fumarate 1,116.59 219.48 897.11 0.07 -28.97 Solution for Inhalation Salmeterol Xinafoate and Fluticasone Propionate 3,042.37 577.16 2,465.20 0.18 131.93 Powder for Inhalation XYP-001 2,589.01 479.56 2,109.45 0.15 5,527.28 Mometasone Furoate and Formoterol Fumarate 145.08 145.08 - 0.01 -65.44 Dihydrate Inhalation Aerosol Formoterol Fumarate 432.91 432.91 - 0.03 9.13 Inhalation Aerosol V-01(COVID-19) 39,010.09 32,244.11 6,765.98 2.27 -20.57 LZM009(PD-1) 6,661.86 4,796.98 1,864.88 0.39 31.18 Triptorelin acetate 6,359.08 6,219.99 139.10 0.37 44.42 60 Joincare Pharmaceutical Group Annual Report 2022 sustained-release microspheres for injection (1 month release) LZM012(IL-17A/F) 3,932.42 3,932.42 - 0.23 154.78 Blonanserin 181.04 181.04 - 0.01 -84.84 Notes: 1. The projects listed above are the main R&D projects conducted by the Company, of which project Blonanserin Tablets is a Priority Review & Approval project. 2. The main reason for the quite significant YoY change in our R&D expenditure is that our R&D projects were in different R&D stages during the Reporting Period. 3. Sales of drugs (products) of the Company (1). Analysis of main sales model √Applicable □N/A Please refer to the “Overview on the businesses of the Company during the Reporting Period” in this Chapter. (2). Analysis of selling expenses Components of selling expenses √Applicable □N/A Unit: 10,000 Yuan Currency: RMB Amount incurred in the Proportion of amount incurred in the Item current period current period to total selling expenses (%) Business promotion expenses 437,208.76 88.31 Employee compensation 45,687.52 9.23 Entertainment and travel 5,036.34 1.02 expenses Business meeting expenses 1,369.68 0.28 Others 5,777.95 1.17 Total 495,080.25 100.00 Horizontal comparison √Applicable □N/A Unit: 10,000 Yuan Currency: RMB Proportion of selling expenses to Comparable peer companies Selling expenses revenues (%) Fosun Pharma 909,900.00 23.33 Kelun Pharma 502,233.28 29.07 CR Double-Crane 280,731.43 30.81 Humanwell Healthcare (Group) 400,667.12 19.50 North China Pharmaceutica 216,131.38 20.81 Total selling expenses of the Company during the Reporting Period 495,080.25 Proportion of selling expenses to revenues during the Reporting 28.88 Period (%) Note: The data regarding comparable companies listed above are from each company's 2021 annual report. Statement on material changes in selling expenses and rationality of selling expenses √Applicable □N/A During the Reporting Period, the Company's selling expenses were RMB4,950.8025 million, accounting for 28.88% of revenues, representing a year-on-year decrease of 1.26%. The increase was mainly due to more efforts to promote products and brands, and an increase in selling expenses 61 Joincare Pharmaceutical Group Annual Report 2022 in prescription drugs which recorded significant sales growth during this period. Looking forward, the Company will continue to deepen the reform of the marketing system to optimize sales channels and increase the cost efficiency for high profitability. 4. Others √Applicable □N/A (V) Analysis of investments Overall analysis of equity investments √Applicable □N/A During the Reporting Period, the Company carried out strategic investments in accordance with our development plans as follow: 62 Joincare Pharmaceutical Group Annual Report 2022 1. Major equity investment √Applicable □N/A Unit: 10,000 Yuan Currency: RMB Whether Litig In the Item on the Impact the target is Invest Expect ation Disclos Disclos Consolidation financial Source Status as of of gain Name of primarily Investment Investment Percentage of Partner (if ment ed invol ure ure Principal business scope of the statement of balance sheet or loss investee engaged in method amount shareholding applicable) period return ved date (if index Company or (if funds date for the investment (if any) (if any) or any) (if any) not applicable) period business not Primarily engaged in technology development, technology Shanghai Sheo consulting, Pharma technology transfer Long-term Capital Technology Capital Own Long and technology No 1,700.00 21.70% No equity N/A contribution - 230.92 No N/A N/A Co., Ltd.(上海 injection funds term services in the investment was completed 偕怡医药科技 fields of medical 有限公司) technology, biotechnology and computer technology. Primarily engaged The parties in pharmaceutical have manufacturing; Jiaozuo completed a health care food Jianfeng total capital manufacturing; New Biotech Co., Own Long contribution of food No establishme 3,325.00 66.50% Yes N/A Greenanew - - No N/A N/A Ltd.(焦作健风 funds term RMB10 manufacturing; nt 生物科技有限 million in food additive 公司) proportion to manufacturing; their cosmetics shareholdings manufacturing, etc. 63 Joincare Pharmaceutical Group Annual Report 2022 Primarily engaged in the research and development of Jiangsu Atom human medicine, Bioscience & veterinary Pharmaceutica medicine, Long-term Capital Capital Own Long l Technology pesticides, health No 3,000.00 3.35% No equity N/A contribution - -510.52 No N/A N/A injection funds term Co., Ltd.(江苏 care products and investment was completed 新元素医药科 chemical products, 技有限公司) product technology transfer, technology consulting, project cooperation. Engaged in all the business of manufacturers, producers, importers, exporters, purchasers, vendors, distribution agents and distributors of LIVZON Capital patents, New BIOLOGICS Own Long contribution pharmaceuticals, No establishme 0.0152 60.43% Yes N/A N/A - - No N/A N/A (MALAYSIA) funds term was not yet medicines, nt SDN. BHD completed nutritional supplem ents, health care products, drugs and vaccine products, and all goods, compounds, and substances commonly used in connection therewith. Shenzhen Biochemical Capital Kangti product technology Long-term contribution of Capital Own Long Biomedical research and No 1,000.00 1.42% No equity N/A RMB6 million - No N/A N/A injection funds term Technology development; investment was completed Co., Ltd.(深圳 technology 64 Joincare Pharmaceutical Group Annual Report 2022 康体生物医药 services, 科技有限公 technology 司) development, technical consulting, technology exchange, technology transfer, technology promotion Total / / / 9,025.0152 / / / / / / / -279.60 / / / Note: Jiangsu Atom Bioscience & Pharmaceutical Technology Co., Ltd. completed its Series C financing on 18 March 2022. 2. Major non-equity investment □Applicable √N/A 3. Financial assets measured at fair value √Applicable □N/A Unit: Yuan Currency: RMB Amount at the Gain or loss on Accumulated Impairment Amount of Amount of disposal Amount at the end of Type of assets beginning of the change in fair value change in fair value provision for the purchase during / redemption during Other change the period period for the period included in equity period the period the period Shares 215,317,489.90 - 6,682,661.01 - - 212,384,666.97 - 9,615,483.94 Private Equity 701,277,471.64 - 33,186,359.03 - 884,764.97 48,229,068.96 - 687,119,526.68 Derivatives 7,376,328.32 -1,943,816.75 - - - - - 5,432,511.57 Others 492,287,415.88 - 40,418,396.69 - - 35,481,944.14 - 497,223,868.43 Others 177,262,015.99 -73,706,840.89 - - 27,978.31 - - 103,583,153.41 Total 1,593,520,721.73 -75,650,657.64 80,287,416.73 - 912,743.28 296,095,680.07 - 1,302,974,544.03 Information on investment in securities Unit: Yuan Currency: RMB 65 Joincare Pharmaceutical Group Annual Report 2022 Amount Carrying Gain or loss on Accumulated Profit Carrying Initial of Amount of Type of Securities Securities Source of amount at the change in fair change in fair or loss amount at the Accounting investment purchase disposal during securities code abbreviation fund beginning of value for the value included for the end of the item cost during the the period the period period in equity period period period Other equity Own Shares 601881 China Galaxy 144,915,000.00 212,384,666.97 - - 0.00 212,384,666.97 - - instrument funds investment Financial Kunlun Own Shares 00135 4,243,647.64 5,976,656.00 -1,001,142.10 - 0.00 0.00 - 4,975,513.90 assets held Energy funds for trading Financial Penghua Own Funds 206001 150,000.00 940,162.94 -5,873.00 - 0.00 0.00 - 934,289.94 assets held Fund funds for trading Financial Huadong Own Shares 000963 39,851.86 13,250,402.40 2,175,439.20 - 0.00 0.00 - 15,425,841.60 assets held Medicine funds for trading Beam Financial Own Shares BEAM(US) Therapeutics, 34,209,846.54 157,094,794.65 -74,876,557.68 - 0.00 0.00 - 82,218,236.97 assets held funds Inc. for trading Financial Own Others 27,978.31 - 1,292.69 - 27,978.31 0.00 - 29,271.00 assets held funds for trading Total / / 134,376,477.81 / 389,646,682.96 -73,706,840.89 - 27,978.31 212,384,666.97 - 103,583,153.41 / Information on investment in private equity fund √Applicable □N/A Gain or Amount of loss on Impairment Amount of Amount at the Accumulated change disposal / Amount at the change in provision purchase Other Type of assets beginning of the in fair value included redemption end of the fair value for the during the change period in equity during the period for the period period period period Qianhai Equity Investment Fund(前海股权 264,930,500.00 - -21,551,757.83 - - - - 243,378,742.17 投资基金) 66 Joincare Pharmaceutical Group Annual Report 2022 PANTHEON D,L.P. 3,715,566.69 - 2,238,734.51 - - - - 5,954,301.20 Shanghai Yunfeng Xinchuang Equity Investment Center(上海云锋新创股权投资 94,040,236.88 - 8,210,913.25 - - 34,315,445.77 - 67,935,704.36 中心) Shanghai Jingyi Investment Center(上海经 66,175,062.50 - 7,441,297.41 - - - - 73,616,359.91 颐投资中心) Information on investment in derivatives √Applicable □N/A Unit: 10,000 Yuan Is this a Initial Investment Percentage of Name of the Investment Amount of related Type of investment Amount of amount at investment amount Actual gain or operator of Related Commence Maturity amount disposal Impairment party derivatives amount of purchase during the to the net assets of loss for the derivatives relationship ment date date at the beginning during the provision (if any) transact investment derivatives the period end of the the Company at the period investment of the period period ion investment period end of the period Forward foreign Financial Non-related No exchange contract 2,108.32 2021/8/3 2022/2/8 2,269.07 - 2,071.02 - - 0.00% 58.89 institution party (sell) Forward foreign Financial Non-related No exchange contract 7,708.90 2021/9/2 2022/3/31 7,835.52 - 7,572.32 - - 0.00% 399.98 institution party (sell) Forward foreign Financial Non-related No exchange contract 11,312.51 2021/10/11 2022/4/7 11,589.76 - 11,227.57 - - 0.00% 183.27 institution party (sell) Forward foreign Financial Non-related No exchange contract 18,301.91 2021/11/1 2022/5/9 18,602.45 - 18,387.38 - - 0.00% 40.70 institution party (sell) Forward foreign Financial Non-related No exchange contract 17,268.19 2021/12/10 2022/6/13 17,664.55 - 9,153.79 - - 0.00% -21.70 institution party (sell) Forward foreign Financial Non-related No exchange contract 17,960.93 2022/1/5 2022/7/26 - 17,960.93 18,439.57 - - 0.00% -384.03 institution party (sell) Forward foreign Financial Non-related No exchange contract 8,197.90 2022/2/10 2022/8/8 - 8,197.90 8,582.48 - - 0.00% -345.20 institution party (sell) 67 Joincare Pharmaceutical Group Annual Report 2022 Forward foreign Financial Non-related No exchange contract 18,437.37 2022/3/11 2022/9/1 - 24,878.83 26,386.53 - - 0.00% -1,310.43 institution party (sell) Forward foreign Financial Non-related No exchange contract 12,507.52 2022/4/7 2022/10/10 - 16,323.43 16,845.74 - - 0.00% -769.47 institution party (sell) Forward foreign Financial Non-related No exchange contract 7,037.84 2022/5/5 2022/11/30 - 7,037.84 7,349.49 - - 0.00% -292.77 institution party (sell) Forward foreign Financial Non-related No exchange contract 10,888.09 2022/6/2 2022/12/23 - 14,447.06 15,034.70 - - 0.00% -559.15 institution party (sell) Forward foreign Financial Non-related No exchange contract 9,319.83 2022/7/4 2023/1/30 - 14,702.35 14,645.26 - 607.17 0.03% -519.13 institution party (sell) Forward foreign Financial Non-related No exchange contract 10,632.66 2022/8/2 2023/2/3 - 16,163.56 14,514.10 - 2,183.36 0.10% -480.15 institution party (sell) Forward foreign Financial Non-related No exchange contract 10,560.82 2022/9/5 2023/2/24 - 12,986.49 7,733.99 - 5,376.80 0.24% -142.27 institution party (sell) Forward foreign Financial Non-related No exchange contract 17,297.95 2022/10/8 2023/4/4 - 19,447.09 8,612.85 - 10,392.16 0.47% 214.17 institution party (sell) Forward foreign Financial Non-related No exchange contract 12,377.21 2022/11/1 2023/4/24 - 15,220.85 3,494.34 - 11,361.13 0.52% 0.41 institution party (sell) Forward foreign Financial Non-related No exchange contract 9,034.15 2022/12/2 2023/6/26 - 9,034.15 80.36 - 8,939.17 0.41% 0.80 institution party (sell) Forward foreign Financial Non-related No exchange contract 14,528.73 2022/4/21 2022/8/4 - 14,528.73 14,986.04 - - 0.00% 333.01 institution party (buy) Forward foreign Financial Non-related No exchange contract 925.07 2022/5/10 2022/12/15 - 925.07 893.48 - - 0.00% -38.11 institution party (buy) Financial Non-related Forward foreign No 1,358.88 2022/9/22 2023/3/21 - 1,358.88 - - 1,355.92 0.06% - institution party exchange contract 68 Joincare Pharmaceutical Group Annual Report 2022 (buy) Forward foreign Financial Non-related No exchange contract 831.80 2022/11/14 2023/2/15 - 831.80 386.81 - 461.69 0.02% 1.12 institution party (buy) Forward foreign Financial Non-related No exchange contract 2,402.70 2022/12/2 2023/6/26 - 2,402.70 1,174.90 - 1,257.76 0.06% 1.89 institution party (buy) Forward foreign Financial Non-related No exchange contract - 2022/12/22 2023/1/30 - 2,091.39 - - 2,089.38 0.09% - institution party (buy) Forward foreign Financial Non-related No exchange contract - 2022/12/29 2023/2/3 - 2,093.79 - - 2,089.38 0.09% - institution party (buy) Total 220,999.29 -- -- 57,961.35 200,632.85 207,572.71 - 46,113.94 2.09% -3,786.71 Source of funds for derivatives investment Own funds Litigation involved (if applicable) Not applicable Disclosure date of the announcement in relation to the approval of investment in derivatives by the Board (if 31 March 2022 any) Disclosure date of the announcement in relation to the approval of derivatives investment by the general Not applicable meeting of shareholders (if any) To effectively manage the uncertainty of exchange rate fluctuations on assets denominated in foreign currency of the Company, foreign exchange forward contracts and other financial derivatives are employed to lock relevant exchange rates for the purpose of hedging. The Company has formulated the Management System for Financial Derivatives Trading (《金融衍生品交易业务管理制度》) in relation to the operation and control of foreign exchange derivatives: 1. Market risk: the uncertainty of exchange rate fluctuations in the foreign exchange market has led to higher market risk in foreign exchange forward business. Control measures: The Company’s foreign exchange forward business is entered into for hedging exchange rate risk associated with assets denominated in US dollar and lock the future exchange settlement price of such assets. It is designed to be used as a hedging instrument. Such foreign exchange derivatives shall not be used for speculative trading. The principle of prudence and conservation shall be Risk analysis of derivatives position held during the observed so as to effectively prevent market risk. 2. Operational risk: operational risk arises from imperfect internal process, improper operation, system failure and other Reporting Period and explanation of control measures factors. Control measures: The Company has formulated the corresponding management measures, clearly defined the responsibilities of all parties, improved the review and (including but not limited to market risk, liquidity risk, approval process and established supervisory mechanism, so as to effectively reduce operational risk. 3. Legal risk: The Company’s foreign exchange forward business is credit risk, operational risk, legal risk, etc.) subject to applicable laws and regulations, and shall clearly stipulate the relationship of rights and obligations with financial institutions. Control measures: In addition to strengthening the knowledge of laws and regulations and market rules in the Company’s responsible department, the Company’s legal department shall also strictly review various business contracts, agreements and other documents, specify the rights and obligations, and strengthen compliance inspection, so as to ensure that the Company’s investment and operation in derivatives have met the requirements of applicable laws and regulations as well as the Company’s internal systems. In order to manage the uncertainty risk caused by price fluctuations of bulk commodities on the purchase cost of raw materials of the Company, financial derivatives such as commodity futures contracts are employed to hedge raw materials. The Company has formulated the Internal Control System for Commodity Futures Hedging Business (《商 69 Joincare Pharmaceutical Group Annual Report 2022 品期货套期保值业务内部控制制度》) to standardize the management and risk control of commodity futures derivatives: 1. Market risk: the uncertainty of price changes of bulk commodities has led to greater market risk in futures business. Control measures: The Company’s futures hedging business shall not carry out speculative trading, the operation principle of prudence and conservation shall be observed, the number of hedging transactions shall be strictly limited, such that it does not exceed the actual number of spot transactions, and the futures position shall not exceed the spot volume for hedging purpose. 2. Operational risk: operational risk arises from imperfect internal process, improper operation, system failure and other factors. Control measures: The Company has formulated the corresponding management system, clearly defined the division of responsibilities and approval process, and established an improved supervisory mechanism, so as to effectively reduce operational risk through risk control of business process, decision-making process and transaction process. 3. Legal risk: The Company’s commodity futures hedging business is subject to applicable laws and regulations, and shall clearly stipulate the relationship of rights and obligations with financial institutions. Control measures: In addition to strengthening the knowledge of laws and regulations and market rules in the Company’s responsible department, the Company’s legal department shall also strictly review various business contracts, agreements and other documents, specify the rights and obligations, and strengthen compliance inspection, so as to ensure that the Company’s investment and operation in derivatives have met the requirements of applicable laws and regulations as well as the Company’s internal systems. Change in market price or fair value of the derivatives invested during the Reporting Period, the specific Gains and losses arising from change in fair value of the forward foreign exchange contracts, option contracts and commodity futures contracts during the Reporting Period method, related assumptions and parameters used in the were RMB-2.5561 million. analysis of the fair value of derivatives shall be disclosed Explanation as to whether there has been a material change in the accounting policy and accounting principles for the Company’s derivatives during the No Reporting Period as compared with the previous reporting period Due to the growing import and export business of the Company, a large amount of foreign exchange transactions are required. To avoid and prevent foreign exchange risk, we are of the view that the forward foreign exchange derivatives trading business carried out by the Company and its subsidiaries are in line with the actual development Specific opinion of independent Directors on needs of the Company. When the Board reviewed this proposal, the relevant investment in derivatives and risk control of the decision-making procedures were in compliance with the Company Law, the Securities Law, the Rules Governing the Listing of Stocks on the Shanghai Stock Exchange and Company other relevant laws and regulations and the provisions in the Articles of Association of the Company. In view of above, we concurred that the Company conducted foreign exchange derivatives trading business with its own funds within the limit approved by the Board. 70 Joincare Pharmaceutical Group Annual Report 2022 4. Progress of Material Asset Restructurings of the Company during the Reporting Period □Applicable √N/A (VI) Sale of major assets and equity □Applicable √N/A (VII) Analysis of major controlled and invested companies √Applicable □N/A Unit: 10,000 Yuan Nature of Main products and Registered Operating Company Asset size Net assets Revenues Net profit business services capital profit R&D, production and sale of oral liquids, tablets (hormone- containing), aerosols (including hormone- Taitai containing aerosols), Industry 10,000 48,195.86 35,935.68 26,623.31 9,040.71 8,470.05 Pharmaceutical inhalation formulations (solution for inhalation) (hormone-containing), nasal sprays (hormone- containing), and dietary supplements Wholesale and retail of skincare products, cosmetics, and other Taitai Industry daily necessities; 500 462.49 59.47 293.69 -56.39 -64.87 Biotechnology domestic trading business, and R&D of dietary supplements Powders for injection (including penicillin- containing powders), tablets, hard capsules, APIs, sterile APIs, inhalation formulations Haibin Pharma Industry (solution for inhalation), 70,000 270,567.22 157,802.84 176,563.89 39,159.15 33,810.82 powders for inhalation, pharmaceutical excipients, R&D technical services, and testing technical services Manufacturing and sale of pharmaceutical intermediates and APIs Xinxiang (excluding proprietary Industry 17,000 157,414.92 38,007.93 76,236.57 7,717.10 6,803.30 Haibin Chinese medicine or TCM decoction pieces) (excluding hazardous chemicals) Production and sale of self-produced dietary Health Industry supplements, TCM HKD7,317 13,541.87 9,352.64 3,113.88 -552.83 -498.57 Pharmaceutical decoction pieces, and drug products R&D of new pharmaceutical products, dietary supplements, medical devices, diagnostic Shanghai reagents, and Industry 5,000 16,314.32 11,460.04 9,813.17 2,808.70 2,666.34 Frontier pharmaceutical intermediates, and provision of relevant technical consulting, technical services and technology transfer 71 Joincare Pharmaceutical Group Annual Report 2022 Technology development of biologics; investment in industry, domestic trading and economic information consulting. Hiyeah Industry Commerce Production of beverages 17,800 617.63 566.30 6.25 -41.55 -41.55 and solid beverages; whole sale of pre- packaged food (excluding reheatable food) Wholesale and retail of skincare products, cosmetics, and other Joincare Daily- Commerce daily necessities; 2,500 3,858.95 3,852.62 - -0.08 -1.46 Use domestic trading business, and R&D of dietary supplements Screening of human disease-specific genes, R&D, production, sale and technical consulting service for genetic engineering drugs and Taitai Industry diagnostic reagents, 5,000 3,635.48 3,635.48 0.17 5.81 5.81 Genomics wholesale of medical devices, and in vitro diagnostic reagents (except for diagnostic reagents under special management) Forensic evidence identification; forensic Appraisal toxicology identification Commerce (limited to ethanol - 964.40 888.16 153.10 -54.39 -57.01 institution detection and drug detection)。 Investment in power and industry; domestic Fenglei Electric Investment commerce, and material 10,000 29,278.31 14,282.70 - 91.86 91.86 Power supply and marketing industry Hong Kong Investment Investment and trading HKD1 35,457.68 835.04 - 131.87 120.99 Pharmaceutical R&D, production and sale of pharmaceuticals, chemical APIs, Jiaozuo Industry biological APIs, 50,000 185,715.54 88,087.38 159,030.74 29,330.87 25,470.94 Joincare pharmaceutical intermediates, and biological products Topsino Commerce Investment and trading HKD89,693 185,901.35 128,993.00 - 44,136.90 44,080.67 According to the laws Health Investment where it was USD5 2,834.63 2,834.63 - - - Investment incorporated R&D, production, storage, transportation and sale of chemical APIs (including intermediates) and Joincare Haibin Industry pharmaceuticals. Import 50,000 98,129.06 82,133.68 68,579.14 42,109.14 36,773.72 and export business and domestic trading (excluding State controlled or franchised goods) R&D, production and sale of formula food, Joincare Special Industry dietary products and 2,000 1,720.47 4.46 - -311.98 -228.08 Medicine Food food for special medical use Drug R&D, production, Livzon Group Industry 93,555 2,486,482.54 1,493,625.16 1,262,957.90 235,055.56 195,554.02 manufacturing and sale (VIII) Structured entities controlled by the Company 72 Joincare Pharmaceutical Group Annual Report 2022 □ Applicable √N/A VI. Discussion and analysis of the Company's future development (I) Industry landscape and trend For details, please refer to the “Basic information on industry” in this chapter. (II) Company's strategies for business development √Applicable □N/A Taking scientific and technological innovation as a strategic priority and executing our dual-drive strategy of developing platforms of both innovative medicines and high-barrier complex formulation, we have been evolving into a world-wide influential innovative pharmaceutical enterprise paying great attention to people's livelihood and actively undertaking social responsibilities. Over the years, the Company has been committed to developing itself in the pharmaceutical field, and has grown into an integrated pharmaceutical enterprise covering multiple areas including chemical pharmaceuticals, biologics, chemical APIs and intermediates, traditional Chinese medicine, diagnostic reagents and equipment. In the future, the Company will continue to increase R&D expenditures to improve its research and innovation capacity, accelerate the optimization and adjustment of its product structure, fully leverage its existing market advantages, and actively deepen the reform of the marketing system, to promote its sustainable and steady business growth. (III) Business plan √Applicable □N/A The year of 2023 is crucial for the transformation of the Chinese market to the “post-pandemic” era, as well as an important window period for the reshaping of the pharmaceutical industry and the transformation and upgrading of enterprises. The main business plans for each business segment of the Company in 2023 are set as follows: 1.R&D Center R&D and innovation are the hard power of the Company to maintain sustainable development. The Company will, on one hand, define the direction of research and development strategy, and screen and evaluate key high- barrier varieties, to enrich and diversify the pipelines; and will, on the other hand, promote product transformation, and effectively advance the research and clinical development of existing core products, to accelerate the launching process. (1) Strategic plannings of R&D and innovation: In recent years, focusing on inhalation formulations, the Group has conducted in-depth research on a few of carefully selected new products with high clinical value and promising market potential, and has achieved good performance. In the future, under the existing R&D pipeline, the Group will focus on the following R&D areas: 1) Inhalation formulations: continue to enrich the pipeline and portfolio of inhalation formulations; 2) Complex injections: Complex injections are mainly microcrystals and liposome injections, with broad clinical application prospect and high technical barrier, and will be added to the Company’s R&D platforms of high-barrier complex formulation ; 3) New drug delivery devices: drugs for respiratory treatment are usually delivered through combined medical instruments with a complex structure, thus posing high requirements on the structural design, performance and quality control. The Group will develop supporting drug delivery devices based on the progress of R&D of drugs for respiratory diseases, improve the industrial chain of inhalation formulations, and enhance the added value and core competitive strengths of products to be launched. (2) Accelerating the commercialization of existing drugs candidates under R&D: Currently, the Company has 244 drug candidates under R&D, including 45 high-barrier complex formulations. In 2023, the Company will focus on promoting the marketing application of indacaterol maleate powder for inhalation, salmeterol xinafoate - fluticasone propionate powder for inhalation, triptorelin acetate microspheres for injection (1-month 73 Joincare Pharmaceutical Group Annual Report 2022 sustained release) and clinical research of XYP-001, Recombinant Anti-Human IL-17A/F Humanized Monoclonal Antibody Injection and other key varieties, while actively promoting the establishment and research of innovative high-barrier complex formulations. (3) In addition to independent research and development, the Company will continue to focus on cutting- edge technologies, enhance external cooperation, proactively carry out innovative business cooperation in the global market, and actively seek opportunities for international expansion of cutting-edge technologies and products through licensing-in, cooperative development and other means. By focusing on its advantageous fields, the Company will also strive to realize product iteration, build its technology platform, and improve the construction of product portfolio in its core and advantageous fields, thus achieving long- term sustainable development. 2. Sales Center The key work deployments in marketing of prescription drugs are as follows: 1. Strengthen team building and improve comprehensive quality through expanding and reinforcing the sales team of hospital channels and the sales team of OTC channels, attracting excellent talents to join the sales team, making brand building a goal, and enhancing the practical capability and comprehensive quality of marketing teams nationwide; 2. Continue to strengthen integration of terminal resources, focus on establishing national benchmark areas, benchmark hospitals and benchmark sales teams, include key hospitals above grade II in appraisal system, and comprehensively enhance the coverage and fulfillment rate of evaluation indicators; 3. Make continuous efforts in commerce, production, end-users and other links, rapidly increase market share and raise brand awareness in all aspects; 4. Continue to advance construction of digital marketing platform and support for end-user market activities, effectively combine online and offline methods, and enhance in-depth brand recognition among doctors and patients; 5. Follow up in real time national medical reform-related policies, strengthen clinical and pharmacoeconomic research of launched products , and actively respond to medical insurance policy adjustments and volume-based procurement. In terms of marketing and promotion of APIs and intermediates, the Company will further strengthen construction of sales team, make full use of OKR and strengthen management by objectives, to build a vigorous and highly efficient sales team; continue to deepen cooperation with global strategic customers, pursue further development in segments, actively develop customer resources, maintain partnership, give full play to the strength of the company brand, and establish a long-term, stable and win-win cooperation model with strategic partners. Moreover, the Company will build good brand reputation in global market through close cooperation with world-class enterprises. In addition, the Company will pay close attention to changes in exchange rates and market conditions and promptly adjust sales strategies. The Company’s pet formulation product, imidacloprid moxidectin drops, was launched in 2022. Considering the characteristics and promising development prospects of animal health products-related business, the Company and our controlled subsidiary Livzon Group jointly invested in the establishment of a joint venture, aiming at integrating the advantages of both sides in the fields of R&D, production, brand promotion, online and offline omni-channel marketing, and further accelerating the business plannings and enhancing efforts of promotion in the field of animal health care. It is conducive to reinforce and enhance the Company’s inherent advantages in the field of animal health care APIs and comprehensive competitiveness of business, and enter the rapidly developing consumer market of animal health care formulations. Health care products, as the Company’s first business segment developed, are attached great importance to the Company's entire marketing strategies. In the future, the Group will implement digital marketing system for increasing the on-line sale; meanwhile, strengthening the “online + offline” synergy to upgrade the offline marketing model. We will continue to promote organizational structure reform of offline channels, channel in- depth distribution and integration of key chains, and strengthen the sales empowerment of offline channels through market resources empowerment, “Menopause Experts’ Views” and chain live-streaming. We will continue to promote digital marketing system, attract off-site drainage and enhance on-site linkage, while we deeply conduct big sales events and deliver festival gift boxes to drive online sales. In terms of content marketing, we expand the KOL cooperation, continue to break through audience boundaries from vertical KOL 74 Joincare Pharmaceutical Group Annual Report 2022 to non-vertical KOL, constantly expanding brand exposure. In terms of brand marketing and building, we will continue to deepen the cooperation with industry associations and professional forums, strengthen the professional building of brands, and carry out corresponding joint cooperation in platform promotion and festival marketing to expand brand exposure and enhance brand sales. In addition, we will continue to increase investment in user operations, and have established a special user operation team to attract, activate and operate users with Wecom as the carrier, improve the WeChat digital mall, loyalty points and content operation system, cultivate original users through user operation, and develop loyal fans belonging to the brand. 3.Production Center On the production side, the Company will continue to strengthen internal operation management, enhance the linkage of production, supply and sales plans and improve the operational efficiency of the supply chain; continue to strengthen quality management throughout the life cycle, attach great importance to the quality control of products and the effective operation of the quality system to prevent major quality and safety incidents; further deepen the promotion of lean production, promote the construction of green energy projects and continue to enhance production efficiency and the domestic driver of energy saving, emission reduction and green environment protection; actively adopt intelligent technology to optimize the production process, achieve cost reduction and efficiency enhancement, and further enhance the competitive edge of core products. 4.Functions and strategies In 2023, in respect of function management, the major tasks are as follows: firstly, we will further improve the Company’s organizational structure and its set-up, and comprehensively promote lean management to reduce costs and improve efficiency; secondly, we will continue to promote the construction of corporate culture, strengthen the publicizing and following of the corporate culture among the Group and its subsidiaries, and enhance corporate cohesion and centripetal force; thirdly, we will continue to strengthen the construction of talents and systems, and improve the objective management system of OKR and KPI in parallel; fourthly, we will actively practice corporate social responsibility, strive to improve corporate governance and promote high-quality and sustainable development of the Company; fifthly, we will actively leverage on our the advantages of internal and external resources to enhance the Group’s brand influence. (IV) Potential risks √ Applicable □ N/A 1. Risks of changes in industrial policies The pharmaceutical manufacturing industry is significantly affected by changes in industrial policies. The pharmaceutical industry will face great challenge in development in the future with continuous deepening of medical reform, advancement of supply-side structural reform in the industry, revision of Drug Administration Law, acceleration of consistency evaluation of generic drugs, adjustment of the new edition of Medical Insurance Catalogue, expansion of volume-based procurement, and other industrial policies that have been successively launched. In July 2022, the Company’s key product Meropenem for Injection (注射用美罗培南) was selected in the seventh batch of volume-based procurement organized by the PRC Government. This volume-based procurement was implemented in November 2022 and will have a great impact on the sales price and market share of this product. Response measures: The Company will pay close attention to industry dynamics and reform, cope with major changes in policies of the pharmaceutical industry through early layout, transformation, and compliance, and actively strengthen new product R&D and innovation and constantly improve its core competitive strengths. Meanwhile, the Company is actively engaged in the access to the national 75 Joincare Pharmaceutical Group Annual Report 2022 reimbursement drug list and negotiation and continue to increase the coverage of hospitals and sales, to realize the objective of “price for quantity”, so as to reduce the impact of price adjustment on the Company’s steady growth. Moreover, the volume-based drug procurement is becoming a regular practice. In the face of the seventh batch of volume-based drug procurement and the possible impact on the business performance of the Company, the Company will continue to strengthen innovation and improve its competitiveness, to ensure sound operation. With the Company’s new high-barrier complex formulation, represented by inhalation formulations appearing on the market one after another, commercialization will gradually enter a stable contribution period. The Company’s product structure will be further optimized, and the reliance on a single product will also gradually reduce. The Company will make continued efforts to innovate and develop innovative medicines and high-barrier complex formulation with high added value that are urgently needed for clinical research, explore the types of existing products with market potential and technical barriers, actively reevaluate key medicines after their marketing and assess the consistency of relevant medicines, continuously optimize the product structure, and actively explore and expand overseas markets. 2. Market risk With advancement of supply-side structural reform in the pharmaceutical manufacturing industry and two invoice policy in circulation domain, pharmaceutical market structure is deeply changed. With the gradual standardization and centralization of the market, competition in the pharmaceutical industry becomes increasingly fierce. Affected by increasingly stricter drug regulation, policy-based drug price reduction, price cutting during bidding, medical insurance premium control, and minimum procurement commitment of the pharmaceutical industry in current stage, bid winning price of drugs will be further lowered, competition among enterprises in the industry will be intensified, and price war will occur frequently, thus the Company will be at the risk of drug price reduction. Response measures: The Company will establish a more reasonable market system through strict compliance operation so as to maintain its dominant position and core competitive strengths, and ensure that it can achieve sustainable and steady development and improve its profitability by reinforcing marketing. Meanwhile, the Company will offset the impact of product price reduction by means of price supplement based on quantity, and optimize technical process and reduce production costs through internal exploration and transformation. Moreover, the Company will speed up the R&D and marketing of new products, spread risks of the Company while expanding the range of existing products in segment markets, improve sales and form new profit growth point by increasing product varieties in the future. 3. Risk of safety and environmental protection The Company is an integrated pharmaceutical manufacturing enterprise. During production, it implements relevant chemical synthesis process and uses a large number of acid and alkali and other chemical components, which are inflammable, explosive, toxic, irritant and corrosive, and have hidden hazards of fire, explosion and poisoning, posing certain risks to the production and operation of the Company. As environmental protection policies and regulations have been constantly issued in recent years, environmental protection standards have become more stringent, and the state has strengthened its control over pollutants, risks of environmental protection of the Company are increasing. Response measures: The Company has always obeyed the safety work concept of “Putting People First” and the guideline of “Safety First, Precaution Crucial and Comprehensive Treatment”. It will strengthen the construction of safe production infrastructure and ensure a sound environment for safe production of the Company through regular internal audit of safety and environment systems as well as employee safety education and training. The Company will carry out discharge after treatment and reaching standards in accordance with environmental protection provisions, actively accept supervision and inspection of environmental protection authorities, and try to reduce emission and increase expenditures in 76 Joincare Pharmaceutical Group Annual Report 2022 environmental protection by improving production process and promptly updating environmental protection technology. 4. Risk in price and supply of raw materials There is a larger fluctuation in the supply price of some raw materials of the Company due to changes in material prices, especially the materials of traditional Chinese medicine, causing greater volatility or rise in production costs of the Company. Meanwhile, the quantity and category of raw material suppliers of the Company are various, thus quality of final products of the Company will be directly affected by the selection of raw material suppliers and the guarantee and control of quality of raw materials. Response measures: In terms of selection of suppliers, the Company will conduct an open tendering and bidding based on the principle of selecting qualified suppliers, strengthen audit of suppliers, and eliminate the adulteration of adverse suppliers. The Quality Assurance Department and Supply Department of the Company will directly conduct process control of products provided by suppliers of key raw materials and carry out quality inspection and control of final products 5. Risk of R&D for new drugs New drug R&D is characterized by high input, high risk and long period. The State has frequently issued drug R&D related policies in recent years to further enhance approval work requirements of new drugs for marketing, thus bringing certain risks for new drug R&D of the Company. Meanwhile, promotion of drugs after marketing is affected by national regulations, industry policies, market environment and competitive intensity, causing that income obtained after marketing of new drugs cannot reach the expected income, making the Company at risk of product R&D. Response measures: The Company will focus on innovative medicines and high-barrier complex formulation, pay attention to unmet clinical needs, and continuously invest in innovative research and development. The Company will further improve the R&D and innovation systems, introduce and develop high-end talents, proactively carry out cooperation and introduction of overseas innovative medicines, strengthen market research and evaluation of varieties, reinforce the process regulation and risk management of the initiation of R&D projects, and concentrate efforts and make key breakthroughs in the R&D of core products. At the same time, the Group’s advantages in APIs will be fully utilized to reinforce the integration of API and drug formulations to ensure the long-term sustainable development of the Company. (V) Others □Applicable √N/A VII. Information not disclosed according to guidelines due to inapplicability of the standard, involving state secrets or trade secrets or other reasons, and notes on relevant reasons □Applicable √N/A 77 Joincare Pharmaceutical Group Annual Report 2022 Chapter 4 Corporate Governance I. Corporate Governance √Applicable □N/A The Company is in compliance with the corporate governance requirements applicable to it as a PRC public company listed on the Shanghai Stock Exchange in all material aspects, including but not limited to the Company Law, the Securities Law, the Guidelines for Corporate Governance of Listed Companies, and the Rules Governing the Listing of Stocks on Shanghai Stock Exchange. During the Reporting Period, the Company continued to improve its corporate governance structure, strengthen information disclosure management and enhance investor relations management and internal control to standardize the operation of the Company. 1. Shareholders and General Meetings During the Reporting Period, 1 annual general meeting and 4 extraordinary general meetings were held by the Company. The Company convened and held general meetings in strict compliance with the Articles of Association, Rules of Procedure for the General Meetings and other relevant regulations to ensure that resolutions can be made at general meetings based on fairness and openness, thereby safeguarding the rights and interests of shareholders. In addition, the Company made full use of modern information technology such as online voting to ensure that all shareholders, particularly minority shareholders, can attend general meetings and exercise their rights to know and participate in decision making in the most convenient and fastest way. 2. Controlling shareholders and the listed company The Company is able to carry on its business and operations independently. In terms of business, personnel, assets, organizations and finance, the Company performed management and accounting independently from the controlling shareholders of the Company. The controlling shareholders of the Company have exercised their rights and assumed their obligations in strict compliance with the laws and regulations, and have never directly or indirectly interfered with the decision-making or business activities of the Company without authorization of the general meeting. The Company has formulated the Management Policy of Joincare Pharmaceutical Group Industry Co., Ltd. for Preventing the Controlling Shareholders or De Facto Controller and Other Related Parties from Appropriating Funds of the Company, and has established a long-term mechanism to prevent the controlling shareholders or de facto controller and their related parties from using funds of the listed company or damaging the interests of the listed company. During the Reporting Period, there was no circumstance where the Company's controlling shareholders, de facto controller, and their related parties embezzled assets of the Company or damaged the interests of the Company and minority shareholders. 3. Directors and the Board During the Reporting Period, the Company held 14 Board meetings in multiple ways, including on-site meeting, voting through electronic means and the combination of on-site meeting and electronic means, providing convenience for the attending directors. During the Reporting Period, the Board of the Company performed its duties actively and effectively in strict compliance with the relevant regulations, including the Company Law, the Articles of Association, and the Rules of Procedure for the Board Meetings. The Board of the Company comprises a total of 9 directors, including 4 independent directors who are legal and financial professionals and provide constructive advice for the effective, standard governance and decision-making on major policies of the Company. Besides, five special committees are set up under the Board of the Company, namely the Audit Committee, the Remuneration Committee, the Strategy Committee, the Nomination Committee, and the Corporate Social Responsibility Committee. These committees assist the Board in performing its decision-making and supervision functions and give full 78 Joincare Pharmaceutical Group Annual Report 2022 play to their expertise, so as to ensure the legality, scientificity, and correctness of decisions made by the Board. During the Reporting Period, the Company convened, held and voted at the board meetings in accordance with the Rules of Procedure for the Board Meetings, and all directors of the Company have attended meetings including the board meetings and general meetings in a conscientious, responsible and honest manner, actively participated in relevant business training, familiarized themselves with relevant laws and regulations, and clarified the rights, obligations and responsibilities of directors. 4. Supervisors and the Supervisory Committee During the Reporting Period, the Company held 12 meetings of the Supervisory Committee for review of the periodic report, option exercise, special report on fund raising, and other matters of the Company. The Supervisory Committee of the Company is comprised of three supervisors, including one employee's representative. During the Reporting Period, the Supervisory Committee of the Company performed its duties in accordance with the law, supervised the duty performance of directors and senior management of the Company, carried out regular inspections on the financial position of the Company, and focused on significant investments of the Company, fully protecting the interests of the Company and all shareholders. 5. Performance evaluation and incentive restraint mechanism for senior management The appointment and dismissal of and reward and punishment for senior management of the Company are performed in strict accordance with the relevant laws, regulations, and the Articles of Association. The Company has established the selection, appointment and performance assessment criteria and the remuneration decision-making procedure for the senior management. The Nomination Committee of the Company provided appropriate candidates for directors and senior management in accordance with the law, and submitted the list of candidates to the Board of the Company for review. The Remuneration Committee of the Company, pursuant to the regulations such as the Management Policy on the Remuneration and Performance Assessment of Senior Management, determined the result of performance assessment of senior management based on the completion of business objectives of the Company and work objectives of the senior management in 2022. Based on the result of performance assessment, the performance bonus and remuneration of senior management in 2022 were determined and submitted to the Board of the Company for review and resolution. 6. Investor relations The Company has always attached great importance to communication and exchange with investors. The Board designated departments and personnel to manage information disclosure and investor relations, enhance communication with minority shareholders, answer questions from shareholders on the production, management and operation of the Company, and listen earnestly to the suggestions and advice of shareholders on the strategy and development of the Company. Without violating regulations, the Company satisfied to the maximum extent the information needs of investors for the sustainable and healthy development of the Company. 7. Information disclosure and transparency The Company disclosed information in a timely, accurate, authentic and complete manner in strict compliance with the relevant regulations, including the Company Law, the Rules Governing the Listing of Stocks on Shanghai Stock Exchange, the Articles of Association, and the Information Disclosure Management Bylaws. The Company designated the Board Secretary to manage information disclosure, receive visitors, answer questions consulted, contact shareholders, and provide investors with the information publicly disclosed by the Company. The Company is able to disclose information in an authentic, accurate, complete and timely manner in accordance with the laws, regulations, and the Articles of Association, and is able to ensure equal access to information for all shareholders. 79 Joincare Pharmaceutical Group Annual Report 2022 8. Stakeholders The Company has fully respected the legitimate rights and interests of stakeholders, including banks, other creditors, employees, consumers, suppliers and communities, and has extended communication and cooperation with such stakeholders based on mutual benefit, so as to jointly promote the sustained and healthy development of the Company and protect the interests of public shareholders. During the Reporting Period, the Company did not provide undisclosed information to its substantial shareholders or de facto controller, and the substantial shareholders and de facto controller of the Company did not interfere with the production, operation and management of the listed company. Overall, no corporate governance irregularities were found. The corporate governance of the Company complies with the Company Law and relevant regulations issued by the CSRC. Achieving good corporate governance is a long journey, which requires continuous improvement. The Company will continue to timely update and improve its internal governance system in accordance with relevant regulations, discover and solve problems in a timely manner, and strengthen internal management, so as to promote standard operation and corporate governance as well as advance the steady and healthy development of the Company. 9. Establishment and implementation of insider registration management system for insider information The Resolution relating to Amendment of the Insider Registration Management System for Inside Information of Joincare Pharmaceutical Group Industry Co., Ltd. was revised and approved at the 8th meeting of the 8th session of the Board of the Company, with a view to strengthening the confidentiality of inside information, maintaining the principles of openness, fairness and justice for the Company's information disclosure, and protecting the legitimate rights and interests of investors. During the Reporting Period, the Board Office of the Company was responsible for the management of inside information of the Company. It is stipulated that the documents and data reported and transmitted externally and other information involving inside information and information disclosure shall be reviewed and approved by the Board or the Board Secretary. When preparing periodic reports and planning significant matters, the Company performed inside information registration timely, and reminded the insiders by mail or phone not to deal with shares of the Company during the sensitive period. Through self-inspection, it was found that there was no circumstance where the insiders dealt with shares and derivatives using inside information of the Company during the Reporting Period. Whether there are any material deviations of the Company's corporate governance from laws, administrative regulations and CSRC regulations on the governance of listed companies; If any, give the reasons. □Applicable √N/A II. Measures taken by the controlling shareholder and de facto controllers to ensure the independence of the Company's assets, personnel, finance, organization, business, in addition to solutions, work schedules and follow-up work plans adopted to enhance the independence of the Company □Applicable √N/A Engagement in the same or similar business as the Company by controlling shareholders, de facto controllers and other units under their control, and the influence of horizontal competition or major changes in horizontal competition on the Company, countermeasures taken, progress and follow-up plan □Applicable √N/A III. Introduction of General Meetings 80 Joincare Pharmaceutical Group Annual Report 2022 Query index of the designated Date of Disclosure Meeting session website for Meeting resolution meeting date publishing the resolution Eight (8) resolutions were considered and approved, including the Resolution on Changing Certain Projects Invested with Proceeds, the Resolution on Revision of Certain Clauses of Articles of Association and 2022 First 11 February 12 February the Resolution on Revision of Certain Clauses Extraordinary www.sse.com.cn 2022 2022 of the Rules of Procedure for the Board General Meeting Meetings. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 2022 First Extraordinary General Meeting (Lin 2022- 014) for details Fourteen (14) resolutions were considered and approved, including the 2021 Annual Work Report of the Supervisory Committee, the Resolution on Election of Mr. Xing Zhiwei as 2021 Annual 19 May Supervisor of the Company and 2021 Annual 18 May 2022 www.sse.com.cn General Meeting 2022 Work Report of the Board of Directors. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 2021 Annual General Meeting (Lin 2022-051) for details Ten (10) resolutions were considered and approved, including the Resolution on the Company’s Issuance of GDRs, listing on the SIX Swiss Exchange and Conversion into a Joint Stock Limited Company Offering Shares Overseas, the Resolution on the Plan for the 2022 Second Company’s Issuance of GDRs and Listing on Extraordinary 8 July 2022 www.sse.com.cn 9 July 2022 the SIX Swiss Exchange and the Resolution on General Meeting Report on the Utilization of the Proceeds Previously Raised by the Company. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 2022 Second Extraordinary General Meeting (Lin 2022-077) for details The Resolution on 2022 Share Options Incentive Scheme (Draft) and its Summary, the Resolution on the Administrative Measures for Appraisal System of the 2022 Share Options Incentive Scheme of the Company and the Resolution on the General 2022 Third 29 August 30 August Meeting for Granting Mandate to the Board to Extraordinary www.sse.com.cn 2022 2022 Deal with Matters Regarding the Share General Meeting Options Incentive Scheme were considered and approved. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 2022 Third Extraordinary General Meeting (Lin 2022- 095) for details Four (4) resolutions were considered and approved, including the Resolution on Repurchase of Shares of the Company through Centralized Bidding Transactions, the Resolution on the General Meeting for 2022 Fourth 19 Granting Mandate to the Board to Deal with 18 November Extraordinary www.sse.com.cn November Matters Regarding the Repurchase and the 2022 General Meeting 2022 Resolution on Change in Registered Capital of the Company. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 2022 Fourth Extraordinary General Meeting (Lin 2022- 134) for details 81 Joincare Pharmaceutical Group Annual Report 2022 Holders of preferred shares with resumed voting rights requesting to hold extraordinary general meeting □ Applicable √ N/A Explanations of General Meetings □ Applicable √ N/A IV. Information on directors, supervisors and senior management (I) Changes in shareholding and remuneration of current directors, supervisors, and senior management and those left the Company during the Reporting Period √Applicable □N/A Unit: shares Total pre-tax remuneration Receive any received Number Number remuneration Change in from the Start date of shares of shares from any End date of shareholding Reason for Company Name Position (Note) Gender Age of the held at the held at the related party the tenure during the change during the tenure beginning end of the of the year Reporting of the year year Company or Period not (RMB Ten thousand) Zhu 28 August 27 August Chairman Male 61 334.09 No Baoguo 2021 2024 Liu 28 August 27 August Vice Chairman Female 54 347.98 No Guangxia 2021 2024 28 August 27 August Equity Yu Xiong Director, President Male 62 660,000 800,000 140,000 360.00 No 2021 2024 incentive Director, Vice Qiu 28 August 27 August Equity President, Chief Male 52 537,409 717,409 180,000 224.93 Yes Qingfeng 2021 2024 incentive Financial Officer Director, Vice 28 August 27 August Equity Lin Nanqi Male 41 1,051,040 1,291,040 240,000 224.93 Yes President 2021 2024 incentive 28 August 27 August Cui Liguo Independent Director Male 53 11.54 No 2021 2024 28 August 27 August Huo Jing Independent Director Female 47 11.54 No 2021 2024 28 August 27 August Qin Yezhi Independent Director Male 49 11.54 No 2021 2024 28 August 27 August Peng Juan Independent Director Female 59 11.54 No 2021 2024 Chairman of Yu 28 August 27 August the Supervisory Male 55 70.13 No Xiaoyun 2021 2024 Committee Peng 28 August 27 August Supervisor Female 61 38,043 38,043 0 4.80 No Jinhua 2021 2024 Purchase Xing 18 May 27 August from the Supervisor Male 37 61,100 0 -61,100 168.88 No Zhiwei 2022 2024 secondary market Xie 28 August 18 May Supervisor(resigned) Male 66 75,442 75,442 0 38.75 No Youguo 2021 2022 Vice President, Zhao 28 August 27 August Equity Secretary to the Male 48 588,000 768,000 180,000 2,010.58 No Fengguang 2021 2024 incentive Board Total / / / / / 2,949,934 3,689,934 740,000 / / Notes: 1. Mr. Zhu Baoguo serves as the chairman of Livzon Group, a controlled subsidiary of the Company; and Mr. Yu Xiong and Mr. Qiu Qingfeng serve as non-executive directors of Livzon Group. The remuneration listed above does not include the part paid by Livzon Group. Please refer to Livzon Group's 2022 Annual Report for details. 2.Upon the consideration and approval at the 2021 annual general meeting of the Company, Mr. Xing Zhiwei has been a Supervisor of the Company with effect from 18 May 2022, after that there was not any change in shareholding. Name Main work experience Male, born in 1962, with a bachelor's degree. He was the director of Henan Xinxiang Waterborne Resin Research Institute, vice chairman and general manager of Henan Feilong Fine Chemical Products Co., Zhu Baoguo Ltd., and had been the general manager and vice chairman of the Company since 1992. He is currently the chairman of the Company and the chairman of Livzon Pharmaceutical Group Inc. Mr. Zhu Baoguo 82 Joincare Pharmaceutical Group Annual Report 2022 is a shareholder of Shenzhen Baiyeyuan Investment Co., Ltd., a controlling shareholder of the Company, and is the de facto controller of the Company. Female, born in 1969, with a college degree. She was the manager of the Advertising Department of CCTV International Corporation Shenzhen, deputy general manager and director of the Company, and Liu Guangxia the vice chairman of Livzon Group. She is currently the vice chairman of the Company. Ms. Liu Guangxia is a shareholder of Shenzhen Baiyeyuan Investment Co., Ltd., a controlling shareholder of the Company, and is the spouse of Mr. Zhu Baoguo, the de facto controller of the Company. Male, born in 1961, researcher. He graduated from the Department of Chemistry of Fudan University with a bachelor of science degree in July 1984. In 1999, he received the special government allowance from the State Council. In 2004, he studied at KU Leuven in Modern Enterprise Management. From July 2005 to January 2006, he worked as a senior visiting scholar at California State University, Northridge. Since 2016, he had been the vice president of the Company. He serves currently as director and president of the Company, director of Livzon Group, chairman of Shanghai Frontier and Haibin Pharma, independent director of Tianjin Tianyao Pharmaceuticals Co., Ltd. and Sichuan Biokin Pharmaceutical Co., Ltd., director of Shanghai Huatai Investment Development Co., Ltd., honorary director of Chinese Pharmaceutical Association, honorary chairman of Pharmaceutical Engineering Yu Xiong Specialized Committee, honorary director of Shanghai Society of Chemistry and Chemical Industry, and adjunct professor of East China University of Science and Technology. He was formerly the vice president of China State Institute of Pharmaceutical Industry, chemistry department director and vice president of Shanghai Institute of Pharmaceutical Industry, chairman of Shanghai Techwell Biopharmaceutical Co., Ltd., legal person of National Shanghai Center for New Drug Safety Evaluation and Research, and general manager and chairman of Sinopharm Yangzhou VAC Biological Engineering Co., Ltd. He was also the person in charge of the comprehensive new drug research and development platform under the national key project of “new drug creation”(Shanghai Institute of Pharmaceutical Industry) and the technical chief of rolling projects under the 12th Five-Year Plan. Male, born in 1971, with an executive master of business administration degree from China Europe International Business School, member of Chinese Institute of Certified Public Accountants (non- practicing). He worked at Tianjin No.1 Machine Tool Works. Since 1996, he had served successively Qiu Qingfeng as the finance personnel, finance supervisor, finance manager, deputy general manager of the Company, and the general manager, board secretary, and president of the Company. He is currently the director, vice president and chief financial officer of the Company and a non-executive director of Livzon Pharmaceutical Group Inc. Male, born in 1982, with a bachelor of engineering degree. He was formerly the workshop supervisor of Chongqing Daxin Pharmaceutical Co., Ltd., the workshop manager, production director and deputy Lin Nanqi general manager of Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc., and the general manager of Jiaozuo Joincare Bio Technological Co., Ltd., a wholly-owned subsidiary of the Company. He is currently the director and vice president of the Company. Male, born in 1970, with a master of laws degree. He is the founding partner and director of Management Committee of Beijing Guantao Law Firm. He is currently an independent director of the Cui Liguo Company, APT Satellite Holdings Limited (security code: 01045), CNNC International Ltd. (security code: 02302), Frontier Services Group Ltd. (security code: 00500), China Coal Xinji Energy Co., Ltd. (security code: 601918) and Beijing Life Insurance Co., Ltd. Female, born in 1976, with a bachelor's degree. She is a member of All China Lawyers Association and Tencent Guangdong Real Estate Think Tank. She was a specially invited lawyer by chinacourt.org, 9ask. cn, 66law.cn, Southern Metropolis Daily, and Shenzhen Evening News. Since 2007, she has been the lawyer and partner of Guangdong Sun Law Firm. She was a member of Real Estate Specialized Huo Jing Committee of Shenzhen Lawyers Association, and served successively as permanent legal adviser to many companies, fully responsible for the review of corporate legal affairs, drafting and amendment of economic contracts, and issuance of legal opinions, with extensive litigation experience for various types of cases. She is currently an independent director of the Company. Male, born in 1974, with a bachelor's degree, a practicing member of Chinese Institute of Certified Public Accountants and China Certified Tax Agents Association, and a non-practicing member of China Certified Public Valuers Association. He successively served as auditor of Shenzhen Zhengfeng Lifu Qin Yezhi Accounting Firm, partner of Shenzhen Jinzheng Accounting Firm, and partner of Asia Pacific (Group) CPAs (Special General Partnership). From 2014 to date, he has served as partner of China Shu Lun Pan Certified Public Accountants LLP. He is currently an independent director of the Company. Female, born in 1964, doctor and doctoral supervisor. From 1997 to date, she has been an associate professor at the Department of Accounting of Antai College of Economics and Management in Shanghai Jiao Tong University, covering research areas of digital finance, green finance, marketing audit, and corporate governance. She is currently an independent director of the Company. She successively served as instructor at the Department of Accounting of School of Economics and Peng Juan Management in Shanghai Maritime University, and director of Executive Education Center of Antai College of Economics and Management in Shanghai Jiao Tong University. She is currently the president and training supervisor of Shanghai Cost Research Society of Shanghai Jiao Tong University, adviser of China Financial Cloud Institute, a member of Behavioral Science Council, a member of Finance and Accounting Association of Shanghai Jiao Tong University, and a member of Green Finance Center of 83 Joincare Pharmaceutical Group Annual Report 2022 Shanghai Environment and Energy Exchange. She served concurrently as independent director of Shanghai Sunglow Packaging Technology Co., Ltd. (stock code: 603499), Dynamiker Biotechnology (Tianjin) Co., Ltd. and Shanghai Sunmi Technology Co., Ltd. Male, born in 1968, with a bachelor's degree, and an MBA degree from University of Greenwich. He is a senior engineer and high-level professional talent of Shenzhen. He worked for Henan Institute of Traditional Chinese Medicine. From December 1992 to date, he has served successively as technical Yu Xiaoyun manager of the Company, government affairs manager of Institute of Traditional Chinese Medicine, and vice president of the Institute. He is currently the adviser of the Institute and chairman of the Supervisory Committee of the Company, and also a standing member of China Healthcare Association. Female, born in 1962, with a college degree. She served as technical data processor at State-owned 272nd Plant of Ministry of Nuclear Industry and accountant of the staff hospital of the Plant, teacher of Hengyang Radio & TV University, and finance manager of Shenzhen New Era Industrial City Industrial Peng Jinhua Co., Ltd. She joined the Company in March 1994, and served successively as finance supervisor, manager of planning and finance department, manager of finance department, manager of tax department, administration manager, and general manager assistant. She is currently a supervisor of the Company. Male, born in 1986. He graduated from Sichuan University majoring in light industry biotechnology with a bachelor's degree. He currently serves as the deputy director of the Center of the Production Management and a supervisor of the Company, the general manager and vice president of the Company’s subsidiary Jiaozuo Joincare Bio Technological Co., Ltd. and a director and the general Xing Zhiwei manager of the Company’s subsidiary Henan Province Joincare Biopharmaceutical Research Institute Co., Ltd. He served successively as workshop supervisor and workshop manager of Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc., and workshop manager, production director and deputy general manager of Jiaozuo Joincare Bio Technological Co., Ltd. Male, born in 1975, with a bachelor of economics degree and master of science degree, member of Jiusan Society. He was formerly the secretary to president of Shenyang Pharmaceutical University, council secretary and office director of Shenzhen Research Center of Traditional Chinese Medicine and Zhao Natural Products, and assistant to director of Chinese Medicine Laboratory of Research Institute of Fengguang Tsinghua University in Shenzhen. Since August 2011, he served successively as manager of project research and management department of the institute of the Company, deputy head and project research director of the institute of the Group, and director of the controlling subsidiary Shanghai Frontier. He is currently the vice president and board secretary of the Company Explanations of other relevant information √Applicable □N/A On 22 April 2022, the Company held the ninth meeting of the eighth session of the Supervisory Committee to consider and approve the Resolution on Nominating Mr. Xing Zhiwei as a Candidate for Supervisor of the Supervisory Committee, and the Supervisory Committee agreed to nominate Mr. Xing Zhiwei as a candidate for Supervisor of the eighth session of the Supervisory Committee of the Company, and submitted this resolution to the general meeting for consideration. On 18 May 2022, the Resolution on Election of Mr. Xing Zhiwei as Supervisor of the Company was considered and approved at the 2021 Annual General Meeting of the Company, pursuant to which Xing Zhiwei serves as the supervisor of the Company for a term commencing from the date of consideration and approval at the General Meeting to the date of expiry of the term of the eighth session of the Supervisory Committee. (II) Posts held by current directors, supervisors, and senior management and those resigned during the Reporting Period 1. Posts held at corporate shareholders of the Company √Applicable □N/A End date Start date of the Name Corporate shareholder Posts held of the tenure tenure Zhu Baoguo Baiyeyuan Chairman, General Manager 11 March 2014 / Liu Guangxia Baiyeyuan Director 21 January 1999 / Mr. Zhu Baoguo, Chairman of the Company, directly holds 90% of shares in Baiyeyuan, and Ms. Liu Guangxia, Vice Chairman of the Company, directly holds 10% of shares in Note Baiyeyuan. Both of them are directors of Baiyeyuan, and Mr. Zhu Baoguo is the spouse of Ms. Liu Guangxia. 84 Joincare Pharmaceutical Group Annual Report 2022 2. Posts held at other entities √Applicable □N/A End date Start date of the Name Other entities Posts held of the tenure tenure Shenzhen Federation of Industry and Honorary Vice November 2014 / Commerce President Federation of Shenzhen Commerce Director April 2015 / Council Member, Zhu TNC Greater China Council of Advisors December 2012 / Secretary General Baoguo The Paradise International Foundation Director April 2015 / China Entrepreneur Club Council Member April 2017 / Central China Management Company Independent Director May 2021 / Limited Shanghai Society of Chemistry and Honorary Director October 2016 / Chemical Industry Tianjin Tianyao Pharmaceuticals Co., Ltd. Independent Director December 2016 / Shanghai Huatai Investment Development Director May 2018 / Co., Ltd. East China University of Science and Yu Xiong Adjunct Professor July 2019 / Technology Sichuan Biokin Pharmaceutical Co., Ltd. Independent Director September 2019 / Pharmaceutical Engineering Specialized Committee of Chinese Pharmaceutical Honorary Chairman November 2019 / Association Chinese Pharmaceutical Association Honorary Director January 2022 / Jiaozuo Jinguan Jiahua Electric Power Co., Director November 2015 / Qiu Ltd. Qingfeng Jiangsu Baining Yingchuang Medical Director November 2020 / Technology Co., Ltd. Jiaozuo Jinguan Jiahua Electric Power Co., Lin Nanqi Director January 2022 / Ltd. Founding Partner, Director of Beijing Guantao Law Firm February 1994 / Management Committee APT Satellite Holdings Limited (listed Independent non- July 2007 / overseas) executive director Independent non- CNNC International Ltd. (listed overseas) November 2008 / executive director Frontier Services Group Ltd.(listed Independent non- Cui Liguo June 2020 / overseas) executive director China Electronics Information Service Co., External Director July 2016 / Ltd. December Essence Securities Co., Ltd. Independent Director November 2016 2022 Beijing Life Insurance Co., Ltd. Independent Director March 2018 / CEC Xinze (Beijing) Investment External Director May 2018 / Management Co., Ltd. China Coal Xinji Energy Co., Ltd. Independent Director May 2019 / Huo Jing Guangdong Sun Law Firm Lawyer, Partner June 2007 / China Shu Lun Pan Certified Public Accountants LLP (Special General Partner July 2014 / Qin Yezhi Partnership) Shenzhen Yongpeng CTA Firm (Special Partner September 2013 / General Partnership) Associate Professor of Antai College of Economics and Department of Peng Juan Management of Shanghai Jiao Tong September 1997 / Accounting, Doctoral University Supervisor 85 Joincare Pharmaceutical Group Annual Report 2022 Kexin Development Co., Ltd., Shanxi Independent Director July 2016 June 2022 August Zhejiang Dibay Electric Co., Ltd. Independent Director August 2016 2022 Jiangsu Pizhou Rural Commercial Bank Independent Director September 2016 July 2022 Dynamiker Biotechnology (Tianjin) Co., Independent Director July 2020 / Ltd. Shanghai Sunglow Packaging Technology Independent Director March 2022 / Co., Ltd. Shanghai Sunmi Technology Co., Ltd. Independent Director May 2022 / Shanghai Jiaopeng Technology Co., Ltd. Supervisor July 2019 / Shanghai Jiaoshang Digital Technology General Manager December 2022 / Co., Ltd. Yu Shenzhen Science and Technology Review Expert November 2022 / Xiaoyun Innovation Commission Shenzhen Nanbei Shengying Industrial Director July 2017 Development Co., Ltd. Peng Jinhua Shenzhen Xinfengfan Technology Supervisor August 2005 Development Co., Ltd. Note Not applicable (III) Remuneration of directors, supervisors and senior management √Applicable □N/A The emolument of chairman and vice chairman of the Company shall follow the Resolutions of the 2018 Second Extraordinary General Meeting of the Company, which is RMB3.25 million per year, with the individual income tax withheld and remitted by the Company in accordance with the relevant provisions of the tax laws. On 29 March 2022 and 18 May 2022, the Company convened the ninth meeting of the eighth session of the Board of Directors and the 2021 Annual General Meeting, respectively, at which the Resolution on Adjusting the Emolument of Independent Directors of the Company(《关于调整公司独立董事津贴的议 案》) was considered and approved, the emolument of each independent director shall be adjusted to RMB10,000 (before tax) from RMB9,000 (before tax) per month, with the individual income tax withheld and remitted by the Company in accordance with the relevant provisions of the tax laws. On 10 August 2021 and 28 August 2021, the Company convened the 39th meeting of the seventh session of the Supervisory Committee and the 2021 Third Extraordinary General Meeting, respectively, at which Resolution on Adjusting the Emolument of the Supervisors of the Company( 《 关于调 整公 司监事津 贴的议 案》 ) was considered and approved, the emolument of each supervisor shall be adjusted to RMB4,000 (before tax) per month from Decision-making RMB3,000 (before tax) per month, with the individual income tax withheld and remitted by procedure regarding the Company in accordance with the relevant provisions of the tax laws. During the Reporting remuneration of Period, the remuneration received by supervisors is the wage based on the wage system of the directors, supervisors Company plus the emolument paid to them. and senior management The remuneration of senior management of the Company shall follow the resolution of the 52th meeting of the 6th session of the Board of the Company. The annual basic remuneration of the president, vice president and other senior management members during the term of office is RMB2.60 million, RMB1.35 million and RMB1.20 million, respectively. In addition to the basic remuneration, pursuant to the regulations such as the Management Policy on the Remuneration and Performance Assessment of Senior Management (《高级管理人员薪酬及 绩效考核管理制度》), individual assessment shall be performed and performance-based bonuses shall be paid according to the assessment result. In case of holding concurrent positions, the highest remuneration among all positions shall prevail. For the Company's directors who serve concurrently as a senior management member of the Company, the remuneration received by them is equal to the wage paid according to their position as a senior management member, and no directors’ emoluments are paid by the Company. On 16 January 2023, the Remuneration Committee under the Board of the Company convened the 8th meeting of the 8th session of the Board, at which the Resolution on the 2022 Annual Performance Assessment Result and Remuneration Distribution of Senior Management of the Company (《关于公司高级管理人员 2022 年度绩效考核结果及薪酬分配的议案》) was 86 Joincare Pharmaceutical Group Annual Report 2022 considered and approved. It was agreed that the Company, pursuant to the regulations such as the Management Policy on the Remuneration and Performance Assessment of Senior Management, determined the 2022 annual performance assessment result and annual remuneration of senior management based on the completion of business objectives of the Company and work objectives of the senior management in 2022. On 16 January 2023, the Board of the Company convened the 22th meeting of the 8th session of the Board, at which the Resolution on Remuneration Distribution of Senior Management for the year 2022 was considered and approved. Except for fulfilling the job responsibilities of being directors, supervisors and senior management of the Company, other remuneration paid for positions held in subsidiaries shall be implemented according to the relevant remuneration system of the corresponding subsidiaries. Pursuant to the regulations such as the Management Policy on the Remuneration and Basis for determining Performance Assessment of Senior Management, the result of performance assessment of remuneration of senior management is determined based on the completion of business objectives of the directors, supervisors Company and work objectives of the senior management in 2022. Based on the result of and senior performance assessment, the performance bonus and remuneration of senior management in management 2022 were determined and submitted to be reviewed by the Remuneration Committee under the Board who shall then submit it to the Board for review and resolution. Remuneration actually paid to As at the date of the Report, remuneration of directors, supervisors and senior management has directors, supervisors been fully paid. and senior management Total remuneration paid to all directors, supervisors and senior RMB20.1058 million. management as of the end of the Reporting Period (IV) Changes in directors, supervisors and senior management √Applicable □N/A Name Position Change Reason for change Xie Youguo Supervisor Resigned Resigned Xing Zhiwei Supervisor Elected Nominated by the Supervisory Committee and elected at the general meeting (V) Statement on punishments imposed by securities regulatory authorities in the last three years □Applicable √N/A (VI) Others □Applicable √N/A V. Board meetings held during the Reporting Period Meeting Date of Meeting resolution session meeting Eighteen (18) resolutions were considered and approved, including the Resolution on Changing Certain Projects Invested with Proceeds, the Resolution on the Opening a New 8th meeting of Special Account Designated for Proceeds and Proposed Signing the Proceeds Escrow the 8th session 2022-01-24 Agreement by the Company and the Resolution on the 2021 Annual Performance of the Board Assessment Result and Remuneration Distribution of Senior Management of the Company. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 8th meeting of the 8th session of the Board (Lin 2022-006) for details Nineteen (19) resolutions were considered and approved, including the 2021 Annual Work Report of the President, 2021 Annual Work Report of the Board of Directors, 2021 Final 9th meeting of Account Report, 2021 Annual Profit Distribution Plan and 2021 Annual Report of Joincare the 8th session 2022-03-29 Pharmaceutical Group Industry Co., Ltd. (Full Text and Abstract). See the Announcement of the Board on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 9th Meeting the 8th Session of the Board of (Lin 2022-026) disclosed on 31 March 2022 for details 87 Joincare Pharmaceutical Group Annual Report 2022 The 2022 Q1 Report of Joincare Pharmaceutical Group Industry Co., Ltd., the Resolution on the Second Phase Ownership Scheme under Medium to Long-term Business Partner Share Ownership Scheme of the Company (Draft) and its Summary, the Resolution on the 10th meeting of General Meeting for Granting Mandate to the Board to Deal with Matters Related to the the 8th session 2022-04-22 Second Phase Ownership Scheme under Medium to Long-term Business Partner Share of the Board Ownership Scheme of the Company and the Resolution on Convening the 2021 Annual General Meeting of the Company were considered and approved. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 10th Meeting of the 8th Session of the Board (Lin 2022-047) disclosed on 25 April 2022 for details The Resolution on the Amendment to the Second Phase Ownership Scheme under Medium to Long-term Business Partner Share Ownership Scheme of the Company (Draft) and its 11th meeting of Summary was considered and approved. See the Announcement of Joincare Pharmaceutical the 8th session 2022-05-31 Group Industry Co., Ltd. on the Amendment to the Second Phase Ownership Scheme under of the Board Medium to Long-term Business Partner Share Ownership Scheme of the Company (Draft) and its Summary (Lin 2022-053) disclosed on 1 June 2022 for details The Resolution on Planning to Issue Global Depository Receipts Overseas and Listing on 12th meeting of the SIX Stock Exchange was considered and approved. See the Indicative Announcement of the 8th session 2022-06-15 Joincare Pharmaceutical Group Industry Co., Ltd. on Planning to Issue Global Depository of the Board Receipts Overseas and List on the SIX Stock Exchange (Lin 2022-061) disclosed on 16 June 2022 for details Twenty (12) resolutions were considered and approved, including the Resolution on the Company’s Issuance of GDRs and Listing on the SIX Stock Exchange and Conversion into a Joint Stock Limited Company Offering Shares Overseas, the Resolution on the Plan for 13th meeting of the Company’s Issuance of GDRs and Listing on the SIX Swiss Exchange and the the 8th session 2022-06-22 Resolution on Report on the Utilization of the Proceeds Previously Raised by the Company. of the Board See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 13th Meeting of the 8th Session of the Board (Lin 2022-063) disclosed on 23 June 2022 for details The Resolution on Adjusting the Exercise Price of the 2018 Share Options Incentive Scheme 14th meeting of of the Company was considered and approved. See the Announcement of Joincare the 8th session 2022-06-30 Pharmaceutical Group Industry Co., Ltd. on Adjusting the Exercise Price of the 2018 Share of the Board Options Incentive Scheme of the Company (Lin 2022-069) disclosed on 1 July 2022 for details Six (6) resolutions were considered and approved, including the 2022 Interim Report of Joincare Pharmaceutical Group Industry Co., Ltd. and its Summary, the Special Report of 15th meeting of Joincare Pharmaceutical Group Industry Co., Ltd. on Deposit and Actual Use of Proceeds the 8th session 2022-08-10 for the half year of 2022 and the Resolution on the 2022 Share Options Incentive Scheme of the Board (Draft) and its Summary. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 15th Meeting of the 8th Session of the Board (Lin 2022-083) disclosed on 11 August 2022 for details The Resolution on Matters Related to the Adjustment of the 2022 Share Options Incentive 16th meeting of Scheme and the Resolution on the First Grant of Share Options to Incentive Participants the 8th session 2022-09-05 were considered and approved. See the Announcement on Resolutions of Joincare of the Board Pharmaceutical Group Industry Co., Ltd. at the 16th Meeting of the 8th Session of the Board (Lin 2022-100) disclosed on 6 September 2022 for details The Resolution on the Cancellation of Certain Share Options Granted but Not Yet Exercised under the 2018 Share Options Incentive Scheme, the Resolution on Repurchase of Shares 17th meeting of through Centralized Bidding Transactions and the Resolution on the General Meeting for the 8th session 2022-10-14 Granting Mandate to the Board to Deal with Matters Regarding the Repurchase. See the of the Board Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 17th Meeting of the 8th Session of the Board (Lin 2022-119) disclosed on 17 October 2022 for details The 2022 Q3 Report of Joincare Pharmaceutical Group Industry Co., Ltd., the Resolution on Change in Registered Capital of the Company, the Resolution on the 18th meeting of Amendment to Certain Clauses of the Articles of Association and the Resolution on the 8th session 2022-10-26 Convening the 2022 Fourth Extraordinary General Meeting of the Company were of the Board considered and approved. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 18th Meeting of the 8th Session of the Board (Lin 2022-124) disclosed on 17 October 2022 for details The Resolution on Co-investment with Controlling Subsidiary Livzon Group was considered 19th meeting of and approved. See the Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. the 8th session 2022-11-28 on Co-investment with Controlling Subsidiary Livzon Group (Lin 2022-136) disclosed on of the Board 29 November 2022 for details 20th meeting of The Resolution on the Establishment of a Joint Venture with Controlling Subsidiary Livzon the 8th session 2022-12-12 Group and the Resolution relating to the Adjustment to Projected Daily Connected of the Board Transactions between Controlling Subsidiaries Jiaozuo Joincare and Jinguan Electric Power 88 Joincare Pharmaceutical Group Annual Report 2022 were considered and approved. See the Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 20th Meeting of the 8th Session of the Board (Lin 2022-141) disclosed on 13 December 2022 for details The Resolution on the Temporary Replenishment of Working Capital with Idle Proceeds was 21th meeting of considered and approved. See the Announcement of Joincare Pharmaceutical Group the 8th session 2022-12-29 Industry Co., Ltd. on the Temporary Replenishment of Working Capital with Idle Proceeds of the Board (Lin 2022-146) disclosed on 30 December 2022 for details VI. Performance of duties by directors (1) Attendance by directors of the Board meetings and general meetings Attendance Attendance of the Board meetings at general meetings Whether Number Whether the indepen of Number director Number of Name Number of Number of Numb dent meetings of has been attendances meetings the meetings er of director attended meetings absent from at the director should attended Absen through attended two general attend for the year in person ces electronic by proxy consecutive meetings means meetings Zhu Baoguo No 14 14 8 0 0 No 4 Liu No 14 14 8 0 0 No 3 Guangxia Yu Xiong No 14 14 8 0 0 No 5 Qiu No 14 14 8 0 0 No 5 Qingfeng Lin Nanqi No 14 14 8 0 0 No 5 Cui Liguo Yes 14 14 8 0 0 No 5 Huo Jing Yes 14 14 8 0 0 No 5 Qin Yezhi Yes 14 14 8 0 0 No 5 Peng Juan Yes 14 14 8 0 0 No 4 Statement on absence from two consecutive meetings □Applicable √N/A Board meetings held during the year 14 In which: On-site meetings 6 Meetings held through electronic means 8 Meetings held both in the form of on-site meeting and through electronic means 0 (2) Objections raised by directors to affairs of the Company □Applicable √N/A (3) Others □Applicable √N/A VII. Board committees √Applicable □N/A (1). Members of the Board committees Committee name Member Audit Committee Qin Yezhi, Huo Jing, Peng Juan Nomination Committee Cui Liguo, Qiu Qingfeng, Huo Jing Remuneration Committee Huo Jing, Qin Yezhi, Peng Juan Strategy Committee Zhu Baoguo, Yu Xiong, Qin Yezhi, Cui Liguo, Peng Juan Corporate Social Responsibility Zhu Baoguo, Lin Nanqi, Cui Liguo (CSR) Committee 89 Joincare Pharmaceutical Group Annual Report 2022 (2). 7 meetings were held by the Audit Committee during the Reporting Period Important opinion Date of meeting Content and suggestion Review of the 2021 Annual Financial Statements of Joincare harmaceutical Group 21 January 2022 Approved Industry Co., Ltd. (Unaudited) Review of the Draft Audit Opinions for the 2021 Annual Financial Statements of 21 March 2022 Approved Joincare Pharmaceutical Group Industry Co., Ltd. Review of the Audit Report for the 2021 Annual Financial Statements of the Approved Company (Final) Review of the Audit Report for the 2021 Annual Internal Control of the Company Approved (Final) Review of the Summary Report on Audit Work for the Year 2021 from Grant Thornton Approved (Special General Partnership) Review of the Self-Assessment Report of Joincare Pharmaceutical Group Industry Co., 29 March 2022 Approved Ltd. on Risk Management and Internal Control for the Year 2021 Review of the Resolution on Appointment of Grant Thornton (Special General Approved Partnership) as the Auditor of the Company for the Year 2022 Review of the Resolution on Daily Connected Transactions between the Controlling Approved Subsidiaries Jiaozuo Joincare and Jinguan Electric Power Review of the Resolution on Providing Loan Guarantee for Jinguan Electric Power by Approved the Company and its Controlling Subsidiary Jiaozuo Joincare 22 April 2022 Review of the 2022 Q1 Report of Joincare Pharmaceutical Group Industry Co., Ltd. Approved 26 October 2022 Review of the 2022 Q3 Report of Joincare Pharmaceutical Group Industry Co., Ltd. Approved 28 November Review of the 2022 Financial Statements and Internal Control Audit Proposal of Approved 2022 Joincare Pharmaceutical Group Industry Co., Ltd. 12 December the Resolution relating to the Adjustment to Projected Daily Connected Transactions Approved 2022 between Controlling Subsidiaries Jiaozuo Joincare and Jinguan Electric Power (3). 4 meetings were held by the Remuneration Committee during the Reporting Period Important Date of Content opinion and meeting suggestion 24 January Review of the Resolution on the 2021 Annual Performance Assessment Result and Approved 2022 Remuneration Distribution of Senior Management of the Company Review of the Review of the Resolution on the 2022 Share Options Incentive Scheme Approved 10 August (Draft) and its Summary 2022 Resolution on the Administrative Measures for Appraisal System of the 2022 Share Approved Options Incentive Scheme of the Company Review of the Resolution on Matters Related to the Adjustment of the 2022 Share Options 5 September Approved Incentive Scheme 2022 Review of the Resolution on the First Grant of Share Options to Incentive Participants Approved 14 October Review of the Resolution relating to Cancellation of Certain Share Options of the Approved 2022 Company Granted but Not Yet Exercised under the 2018 Share Options Incentive Scheme (4). 4 meetings were held by the Strategy Committee during the Reporting Period Date of Important opinion Content meeting and suggestion Review of the Resolution on Planning to Issue Global Depository Receipts 15 June 2022 Approved Overseas and Listing on the SIX Stock Exchange Review of the Resolution on the Company’s Issuance of GDRs and Listing on the SIX Stock Exchange and Conversion into a Joint Stock Limited Company Offering Approved Shares Overseas 22 June 2022 Review of the Resolution on the Plan for the Company’s Issuance of GDRs and Approved Listing on the SIX Swiss Exchange Review of the Resolution on the Plan for the Use of Proceeds Raised by the Approved Issuance of GDRs 28 November Review of the Resolution on Co-investment with Controlling Subsidiary Livzon Approved 2022 Group 90 Joincare Pharmaceutical Group Annual Report 2022 12 December Review of the Resolution on the Establishment of a Joint Venture with Controlling Approved 2022 Subsidiary Livzon Group (5). 2 meetings were held by the Corporate Responsibility Committee during the Reporting Period Important opinion Date of meeting Content and suggestion Review of the 2021 Corporate Social Responsibility Report of Joincare Approved Pharmaceutical Group Industry Co., Ltd. Review of the Resolution on the Set-up of Environmental Management Approved 29 March 2022 Targets for Carbon Emissions of Joincare Group Review of the Resolution on the Introduction of ESG Indicator Assessment Mechanism into Individual Performance of the Corporate Responsibility Work Approved Group of Joincare Pharmaceutical Group Review of the Resolution on the Establishment of 2022 Corporate 23 November Responsibility Work Group of Joincare Pharmaceutical Group Industry Co., Approved 2022 Ltd. (6). Affairs subject to objection □Applicable √N/A VIII. Statement on risks of the Company identified by the Board of Supervisors □Applicable √N/A The Supervisory Committee had no objection to the matters under their supervision within the reporting period. IX. Employees of the parent company and major subsidiaries (I) Employees Number of active employees of the parent company 517 Number of active employees of major subsidiaries 13,599 Total number of employees 14,116 Number of retired employees for whom the parent company and major 669 subsidiaries need to pay certain expenses Profession Category Number Production staff 8,312 Sales staff 2,635 Technical staff 2,181 Financial staff 258 Administrative staff 730 Total 14,116 Education background Education background Number PhD 64 Postgraduate 620 Undergraduate 3,730 Junior college diploma 4,021 Others 5,681 Total 14,116 (II) Compensation policy √Applicable □N/A The Company implements scientific, reasonable and incentive-based compensation strategies. Based on scientific analysis and assessment of the organizational structure and job responsibilities, the Company determines the relative value of each position, and by combining the external market compensation data and the ability of the Company to pay, the Company provides a reasonable employee compensation package. Employee compensation consists of two parts: fixed income and variable income. Variable income is linked to business results of the Company and individual performance of employees. In this 91 Joincare Pharmaceutical Group Annual Report 2022 way, employees are encouraged to increase their enthusiasm and motivation at work. Competitive compensation policies are adopted for talents in key positions and those urgently needed in the market, so as to prevent loss of key talents and provide a talent pool for the development of the Company. (III) Training programs √Applicable □N/A In 2022, the Company continued to attach great importance to internal talent training. With multi-level, diversified training systems and a combination of online and offline learning, the Company organized and carried out new employee orientation training, employee on-the-job training, career-based study for a master's or doctor's degree, training and team building. Meanwhile, the Company encouraged employees to actively participate in external learning activities related to work, facilitated the improvement of employee competence and team cohesion, and built talent teams. (IV) Outsourced workers □Applicable √N/A X. Profit distribution proposal or proposal for capitalization of capital reserve (I) Formulation, implementation or adjustment of cash dividend distribution policy √Applicable □N/A 1. Cash dividend distribution policy and its formulation To establish a scientific, consistent and stable decision-making and supervision mechanism for dividends, and fully protect and safeguard the rights and interests of the majority of shareholders, the Company formulated this cash dividend policy in accordance with the Regulatory Guidelines for Listed Companies No. 3 - Distribution of Cash Dividends of Listed Companies released by the CSRC (CSRC announcement [2022] No. 3) and the Regulatory Guideline for Self-regulation of Listed Companies No. 1 - Standardized Operation released by Shanghai Stock Exchange and other relevant documents and requirements, and in light of the reality of the Company, clarified the formulation, decision-making and adjustment procedures for the policy in the Articles of Association: If the Company is in a sound operating condition and its cash flow can meet the needs of normal operation and long-term development, the Company shall actively implement the profit distribution policy to provide reasonable returns to investors while taking into account the sustainable development of the Company, in order to maintain the continuity and stability of the policy. The profits may be distributed in cash, stocks, or combination thereof or in any other way permitted by laws and regulations. Cash dividends are superior to stock dividends in the distribution of profits, and shall be adopted whenever the conditions are met. Unless otherwise provided for in the Articles of Association, the profits distributed in cash shall not be less than 10% of the distributable profits realized in the current year. The specific amount and proportion of cash dividends for each year shall be determined by the Board of Directors of the Company in accordance with relevant provisions and in light of the Company's current operating situation, and shall be reported to the annual general meeting for deliberation and decision. 2. Implementation of cash dividend distribution policy in 2022 On 18 May 2022, the Company convened the 2021 Annual General Meeting, at which the Company's Profit Distribution Plan for 2021 was considered and approved: a cash dividend of RMB1.50 (tax inclusive) will be distributed to all shareholders for every 10 shares, based on the total share capital of the Company on the equity registration date as determined for implementation of the Company's profit distribution plan for 2021, minus the total number of shares in the Company's special securities account for repurchase, with the remaining undistributed profits to be carried forward to the following year. As of the end of this Reporting Period, the above cash dividends have been fully distributed. 92 Joincare Pharmaceutical Group Annual Report 2022 3. Profit distribution scheme for 2022 Based on the audit conducted by Grant Thornton (Special General Partnership), in 2022, the Parent Company generated net profit of RMB849,731,957.95, 10% of which was contributed to the statutory surplus reserve, namely RMB84,973,195.80, the remainder of which, together with undistributed profits for the last year of RMB1,400,174,178.18 and gain on disposal of other equity investments of RMB80,749,859.60, subtracting cash dividends for the last year of RMB277,557,631.65, is the profits available for distribution to shareholders for the year of RMB1,968,125,168.28.The Company plans to distribute cash dividends for the fiscal year 2022, based on the total number of shares for dividend distribution, which is defined by the total shares of Company, minus the shares in the Share Repurchase Account, on the equity registration date designated by the annual profit distribution plan. The Company plans to distribute cash dividend of RMB1.80 (tax inclusive) for every 10 shares of to all shareholders of the Company, and the remaining undistributed profits will be carried forward to the following year. 4. Modification and adjustment of the cash dividend distribution policy during the Reporting Period The Company's cash dividend policy was not modified or adjusted during the Reporting Period. (II) Special statement on cash dividend distribution policy √Applicable □N/A Whether it meets the requirements of the articles of association or the resolution of the general meeting √Yes □No Are there defined and clear distribution qualifications and proportions √Yes □No Are there well-designed decision-making procedures and system √Yes □No Have independent directors performed their duties and role properly √Yes □No Whether the minority shareholders have the chance to fully express their opinions and demands and √Yes □No whether their legitimate rights and interests have been well protected (III) If the Company made a profit during the Reporting Period and there's profit distributable by the parent company to shareholders, but the Company does not propose to distribute profits in cash, the Company shall explain the reason in detail, usage of the undistributed profit and usage plan □Applicable √N/A (IV) Profit distribution and conversion of capital reserve into share capital for the Reporting Period √Applicable □N/A Unit: Yuan Currency: RMB Number of bonus shares to be distributed for every ten shares (share) 0 Amount to be distributed for every ten shares (RMB) (tax inclusive) 1.80 Number of shares to be converted into share capital for every ten shares (share) 0 Amount of cash dividend (tax inclusive) 342,139,018.68 Net profit attributable to ordinary shareholders of the listed company in the consolidated 1,502,595,840.48 financial statement during the year of distribution Percentage of the net profit attributable to ordinary shareholders of the listed company 22.77 in the consolidated financial statement (%) Amount of repurchase of shares under cash offer included in cash dividend 724,513,822.62 Total amount of dividend (tax inclusive) 1,066,652,841.30 Total amount of dividend as a percentage of the net profit attributable to ordinary 70.99 shareholders of the listed company in the consolidated financial statement (%) Note: The Company proposes to distribute cash dividend of RMB1.80 (tax inclusive) for every 10 shares to all shareholders of the Company (except for those in the Share Repurchase Account of the Company). The cash dividends proposed to be distributed for 2022 will be RMB342,139,018.68 (tax inclusive) based on the total share capital of 1,929,189,374 shares less the 28,417,048 shares in the Share Repurchase Account of the Company as of 31 December 2022. The final and actual total distribution amount is calculated based on the total shares entitled to participate in the equity distribution on the equity registration date for the implementation of equity distribution. 93 Joincare Pharmaceutical Group Annual Report 2022 XI Share incentive plan, employee share ownership scheme and other employee incentives of the Company and their effect (1) Matters related to equity incentive scheme have been disclosed have been disclosed in the provisional announcements without progress or change in subsequent implementation √Applicable □N/A Overview Query index The number of share options exercised was 4,005,170 from 1 See the Announcement on 2022 Q1 Independent Exercise January 2022 to 31 March 2022. As of 31 March 2022, the Results of the 2018 Share Options Incentive Scheme of number of options cumulatively exercised and completing share Joincare Pharmaceutical Group Industry Co., Ltd. & transfer registration during the exercise period of the first grant Changes in Shares (Lin 2022-038) disclosed by the and reserved grant under the 2018 Share Options Incentive Company on 2 April 2022 for details. Scheme of the Company was 28,835,036. The Resolution on the Second Phase Share Ownership Scheme under Medium to Long-term Business Partner Share Ownership See the relevant Announcements on the Second Phase Scheme of the Company (Draft) and its Summary and the Share Ownership Scheme under Medium to Long-term Resolution on the General Meeting for Granting Mandate to the Business Partner Share Ownership Scheme of Joincare Board to Deal with Matters Related to the Second Phase Share Pharmaceutical Group Industry Co., Ltd. (Draft) and its Ownership Scheme under Medium to Long-term Business Summary disclosed by the Company on 25 April 2022 for Partner Share Ownership Scheme of the Company were details; considered and approved at the Congress of Workers and Staff, See the Announcement on Resolutions of Joincare the 10th Meeting of the 8th Session of the Board, and the 9th Pharmaceutical Group Industry Co., Ltd. at the 2021 Meeting of the 8th Session of the Supervisory Committee on 22 Annual General Meeting (Lin 2022-051) disclosed by the April 2022. Company on 19 May 2022 for details. The said resolutions were considered and approved at the 2021 Annual General Meeting on 18 May 2022. See the Announcement on Resolution in Relation to Revision of the Second Phase Share Ownership Scheme The Resolution on Revision of the Second Phase Share under Medium to Long-term Business Partner Share Ownership Scheme under Medium to Long-term Business Ownership Scheme of Joincare Pharmaceutical Group Partner Share Ownership Scheme of Joincare Pharmaceutical Industry Co., Ltd. (Draft) and its Summary (Lin 2022- Group Industry Co., Ltd. (Draft) and its Summary was 053), and the Second Phase Share Ownership Scheme considered and approved at the 11th Meeting of the 8th Session under Medium to Long-term Business Partner Share of the Board and at the 10th Meeting of the 8th Session of the Ownership Scheme of Joincare Pharmaceutical Group Supervisory Committee on 31 May 2022. Industry Co., Ltd. (Revised Draft) and its Summary disclosed by the Company on 1 June 2022 for details. On 1 June 2022, the First Holders’ Meeting of the Second Phase Share Ownership Scheme of Medium to Long-term Business Partners was held by the Company, at which the Resolution on See the Announcement on Resolutions of Joincare Establishing the Management Committee of the Second Phase Pharmaceutical Group Industry Co., Ltd. at the First Share Ownership Scheme of the Company, the Resolution on Holders’ Electing Members of the Management Committee of the Second Meeting of the Second Phase Share Ownership Scheme of Phase Share Ownership Scheme and the Resolution on Medium to Long-term Business Partners (Lin 2022-056) Authorizing the Management Committee of the Second Phase disclosed by the Company on 2 June 2022 for details. Share Ownership Scheme of the Company to Handle Matters Related to the Employee Share Ownership Scheme were considered and approved. As of 7 June 2022, the Second Phase Share Ownership Scheme of the Company has purchased a total of 6,275,372 shares by See the Announcement of Joincare Pharmaceutical Group way of secondary market centralized bidding trading, Industry Co., Ltd. on Completing the Purchase of Shares representing 0.33% of the total share capital of the Company at for the Second Phase Share Ownership Scheme under that time, with a total turnover of RMB75,740,661.60 and an Medium to Long-term Business Partner Share Ownership average transaction price of approximately RMB12.07 per share. Scheme (Lin 2022-059) disclosed by the Company on 8 Then the Company has completed the purchase of the underlying June 2022 for details. shares for the Second Phase Share Ownership Scheme. The Resolution on Adjusting the Exercise Price of the 2018 Share Options Incentive Scheme of the Company was See the Announcement on Adjusting the Exercise Price of considered and approved at the 14th Meeting of the 8th Session the 2018 Share Options Incentive Scheme of the Company of the Board and at the 12th Meeting of the 8th Session of the by Joincare Pharmaceutical Group Industry Co., Ltd. (Lin Supervisory Committee on 30 June 2022. Due to profit 2022-069) disclosed by the Company on 1 July 2022 for distribution, the exercise price under the first grant was adjusted details. to RMB7.59 per share, while that under the reserved grant was adjusted to RMB10.01 per share. 94 Joincare Pharmaceutical Group Annual Report 2022 The number of options exercised in total was 807,589 from 1 See the Announcement on 2022 Q2 Independent Exercise April 2022 to 30 June 2022. As at 30 June 2022, the number of Results of the 2018 Share Options Incentive Scheme of options cumulatively exercised and completing share transfer Joincare Pharmaceutical Group Industry Co., Ltd. & registration under the first grant and reserved grant of the 2018 Changes Share Options Incentive Scheme of the Company was in Shares (Lin 2022-071) disclosed by the Company on 2 29,642,625. July 2022 for details. See the Announcement on the 2022 Share Options The Resolution on the 2022 Share Options Incentive Scheme Incentive Scheme (Draft) and its Summary of Joincare (Draft) and its Summary of the Company and other relevant Pharmaceutical Group Industry Co., Ltd. (Lin 2022-087) resolutions were considered and approved at the 15th Meeting and relevant announcements disclosed by the Company on of the 8th Session of the Board and at the 13th Meeting of the 11 August 2022 for details; 8th Session of the Supervisory Committee on 10 August 2022. See the Announcement on Resolutions of Joincare The above resolutions were considered and approved at the 2022 Pharmaceutical Group Industry Co., Ltd. at the 2022 third third extraordinary general meeting on 29 August 2022. extraordinary general meeting (Lin 2022-095) disclosed by the Company on 30 August 2022 for details. The Resolution on the Matters Related to the Adjustment of the 2022 Share Options Incentive Scheme and the Resolution on the See the Announcement on the Matters Related to the First Grant of Share Options to Incentive Participants were Adjustment of the 2022 Share Options Incentive Scheme considered and approved at the 16th Meeting of the 8th Session of Joincare Pharmaceutical Group Industry Co., Ltd. (Lin of the Board and at the 14th Meeting of the 8th Session of the 2022-101), the Announcement on the First Grant of Share Supervisory Committee on 5 September 2022. The number of Options to Incentive Participants of Joincare incentive participants under this incentive scheme was adjusted Pharmaceutical Group Industry Co., Ltd. (Lin 2022-102) from 430 to 423, while the number of share options granted was and other relevant announcements disclosed by the adjusted from 55,000,000 to 54,950,000. The first grant date was Company on 6 September 2022 for details. 5 September 2022, and 49,450,000 share options were granted to 423 incentive participants. The number of options exercised was 2,249,270 from 1 July See the Announcement on 2022 Q3 Independent Exercise 2022 to 30 September 2022. As at 30 September 2022, the Results of the 2018 Share Options Incentive Scheme of number of options cumulatively exercised and completing share Joincare Pharmaceutical Group Industry Co., Ltd. & transfer registration under the first grant and reserved grant of Changes in Shares (Lin 2022-115) disclosed by the the 2018 Share Options Incentive Scheme of the Company was Company on 11 October 2022 for details. 31,891,895. The Resolution relating to the Cancellation of Certain Share Options of the Company Granted but Not Yet Exercised under the 2018 Share Option Incentive Plan was considered and approved at the 17th meeting of the 8th session of the Board and the 15th meeting of the 8th session of the Supervisory See the Announcement on the Cancellation of Certain Committee of the Company on 14 October 2022, 26,000 share Share Options of the Company Granted but Not Yet options under the reserved grant that have been granted but not Exercised under the 2018 Share Option Incentive Plan of yet exercised by certain incentive participants were cancelled Joincare Pharmaceutical Group Industry Co., Ltd. (Lin due to not being exercised by them within the validity period of 2022-120) disclosed by the Company on 17 October 2022 the options. for details. Upon review and confirmation by the Shanghai Branch of China Securities Depository and Clearing Corporation Limited, the said cancellation of 26,000 share options was completed on 24 October 2022. The number of options exercised was 1,534,105 from 1 October See the Announcement on 2022 Q4 Independent Exercise 2022 to 31 December 2022. As at 31 December 2022, the Results of the 2018 Share Options Incentive Scheme of number of options cumulatively exercised and completing share Joincare Pharmaceutical Group Industry Co., Ltd. & transfer registration under the first grant and reserved grant of Changes in Shares (Lin 2023-001) disclosed by the the 2018 Share Options Incentive Scheme of the Company was Company on 4 January 2023 for details 33,426,000. (2) Incentives not disclosed in the provisional announcements or with subsequent progress Equity incentives □Applicable √N/A Others □Applicable √N/A Employee share ownership scheme □Applicable √N/A 95 Joincare Pharmaceutical Group Annual Report 2022 Other incentive program □Applicable √N/A (3) Equity incentives granted to directors and senior management during the Reporting Period √Applicable □N/A Unit: 10,000 shares Number Number of Number Number Market of share newly Number of of of share price at options granted exercisable exercised Exercise price options the end of held at share options options Name Title of share held at the the options during the during options(RMB) the end Reporting beginning during the Reporting the of the Period of the Reporting Period Reporting period (RMB) year Period Period Director, Yu Xiong 14 80 14 14 7.74 80 11.29 President Director, Vice Lin Nanqi 24 80 24 24 7.74 80 11.29 President Director, Vice Qiu President, Chief 18 60 18 18 7.74 60 11.29 Qingfeng Financial Officer Zhao Vice President, 18 60 18 18 7.59 60 11.29 Fengguang Board Secretary Total / 74 280 74 74 / 280 / (4) Performance assessment mechanism for senior management during the Reporting Period, and the development and implementation of incentive scheme √Applicable □N/A According to the relevant provisions of the Company such as the Remuneration and Performance Appraisal Management System for Senior Management, the plans on performance appraisal results and remuneration of senior management for the year 2022 are set based on the completion of the operation targets of the Company and the corresponding personal performance of each senior management for the year 2022. The plans shall be submitted to the Board for review and approval. During the Reporting Period, senior management of the Company faithfully performed their duties in strict accordance with the Company Law, the Articles of Association and other relevant regulations, actively implemented the relevant resolutions of the Company's General meetings and the Board meetings, actively adjusted business plans under the guidance of the Board, continuously strengthened internal control management, and strived to improve the Company's core competitiveness. XII. Development and implementation of internal controls during the Reporting Period √Applicable □N/A During the Reporting Period, the Company carried out standard operation and risk control in strict accordance with the laws and regulations in China and the internal control system of the Company. The Company established a rigorous internal control management system, continued to optimize and improve the internal control system by combining the industry characteristics and the actual operation of the Company, enhanced its decision-making efficiency, and ensured the legal compliance of business management and the security of corporate assets, facilitating the steady implementation of strategies of the Company. Thanks to an effective internal control mechanism, the Company can prevent, timely identify and correct any deviation in the operation and management, and can reasonably ensure the security and integrity of corporate assets, as well as the authenticity, accuracy and completeness of accounting information, safeguarding the interests of the Company and all shareholders. 96 Joincare Pharmaceutical Group Annual Report 2022 Based on the identification of material deficiencies of internal control of the Company, there was no material deficiency or significant deficiency of internal control over financial reporting and non-financial reporting in the Company for the year 2022. Through operation, analysis and evaluation of the internal control system, the Company effectively prevented business management risks, and promoted the achievement of internal control objectives. Looking ahead, the Company will continue to improve the internal control system, standardize its implementation, strengthen the supervision and inspection over internal control, and promote the healthy and sustainable development of the Company. See the Risk Management and Internal Control Self-Assessment Report 2022 of Joincare Pharmaceutical Industry Group Co., Ltd. disclosed by the Company on 11 April 2023 for details. Statement on material loopholes in internal controls during the Reporting Period □Applicable √N/A XIII. Management and control of subsidiaries during the Reporting Period √Applicable □N/A The Company formulated relevant subsidiary management rules, such as the Detailed Rules for Standardized Operation and Management of Subsidiaries, to strengthen internal control of wholly-owned and majority-owned subsidiaries by specifying their governance structure, the management of the Board, the general meetings and the Supervisory Committee, special transactions, legal person's authorization and relevant issues, to improve the Company's overall operating efficiency and risk control capability. During the Reporting Period, the Company exercised management and control over its subsidiaries in accordance with the Company Law, the Articles of Association and other relevant laws and regulations. First, it provided guidance for the subsidiaries as to how to improve the corporate governance structure, and how to revise and improve the Articles of Association and other relevant systems in accordance with relevant laws and regulations; second, through internal training such as training on connected transactions, the Company urged subsidiaries to report to the Company on connected transactions, external guarantee and other major matters in advance; third, the Company updated the internal control manual and related materials, to improve the internal control system, and strengthen implementation and enhance the effectiveness of internal control. XIV. Related information on internal control audit report √Applicable □N/A In accordance with relevant standards, guidelines and regulatory documents, and upon the approval by the audit committee of the Board of Directors, the Board of Directors and the general meeting, the Company engaged Grant Thornton China (special general partnership) to conduct internal control audit in 2022. In accordance with the Basic Standards for Enterprise Internal Control and the Application Guidelines for Enterprise Internal Control, Grant Thornton China conducted audit of the effectiveness of internal control over financial reporting of the Company and its subsidiaries as of 31 December 2022, and issued a standard internal control audit report with unqualified opinion. See the Internal Control Audit Report 2022 of Joincare Pharmaceutical Industry Group Co., Ltd. disclosed by the Company on 11 April 2023 for details. Disclosure of internal control auditor's report: Yes Types of internal control auditor's opinion: Standard unqualified opinion XV. Rectification of self-examined deviations in the Special Action for Governance of Listed Companies 1. Optimization of the meeting convening methods of the Board of Directors and Special Committees of the Board Description: At present, the Board of Directors and the special committees mostly hold meetings through electric means which is not conducive to full expression of opinions by directors. 97 Joincare Pharmaceutical Group Annual Report 2022 Rectification measures: In order to ensure that directors can fully express their opinions, the Company will increase the number of on-site meetings of the Board of Directors and its special committees. In particular, on-site meetings or on-site + virtual means will be held for matters related to major asset purchase or sale or major connected transactions in the future. In 2022, the Company held 6 meeting through a combination of on-site + virtual means, accounted for 42.86% of the number of all meetings, representing an increase of 38.51% over 2021 2. Improvement of the audit institution selection and engagement review process Description: The special self-inspection found that the Company engaged the audit institution based on inquiry into public available information on its professional competence and integrity, without consulting the record of integrity of the audit institution in the securities and futures market through the China Securities Regulatory Commission in advance. Rectification measures: From 2021, in addition to the inquiry into public available information, the Company would, before selecting and engaging an audit institution, consult the records of integrity of the audit institution and relevant certified public accountants to be engaged in the securities and futures market as maintained by Shenzhen Securities Regulatory Bureau, to fully learn about its practicing experience, professional competence and integrity XVI. Others □Applicable √N/A 98 Joincare Pharmaceutical Group Annual Report 2022 Chapter 5 Environmental and Social Responsibility I. Environmental information If the environment protection mechanism was Yes established Amount of funds invested in environment protection 12,273.48 during the Reporting Period (Unit: RMB0’000) (I) Environmental issues of companies and their major subsidiaries belonging to key pollutant discharging units as announced by the environmental protection department √ Applicable □ N/A 1. Pollution discharge information √ Applicable □ N/A ⅰJiaozuo Joincare Pollutant Total Number Total Name of Name of major Number of Discharge discharge amount of Mode of of amount of Excessive company or pollutants and discharge concentratio standards discharge discharge discharge discharge discharge subsidiary specific pollutants outlets n (mg/L) implemented approved outlets (t/a) (mg/L) (t/a) Chemical oxygen Master outlet in Continuous 119 220 757 942.1 Nil Jiaozuo demand sewage 1 Joincare Ammonia treatment Continuous 14 35 91 105.3 Nil nitrogen workshop ⅱTaitai Pharmaceutical Pollutant Total Name of major Number Total Name of Number of Discharge discharge amount of pollutants and Mode of of amount of Excessive company or discharge concentratio standards discharge specific discharge discharge discharge discharge subsidiary outlets n (mg/L) implemented approved pollutants outlets (t/a) (mg/L) (t/a) Chemical 39.44 345 0.35 19.34 Nil oxygen demand Biochemical Master outlet in sewage 3.05 150 0.021 / Nil oxygen demand Intermittent 1 treatment Suspended Taitai workshop 4 250 0.034 / Nil solids Pharmaceutical pH value 7.66 6~9 / / Nil Sulfur dioxide 1.69 50 0.20 / Nil Discharge Nitrogen oxide 13.92 150 0.16 / Nil Intermittent 1 outlet of boiler Particulate exhaust gas 14.26 20 0.15 / Nil matter iii Haibin Pharma Pollutant Total Name of major Number Total Name of Discharge discharge amount of pollutants and Mode of of Number of discharge amount of Excessive company or concentratio standards discharge specific discharge discharge outlets discharge discharge subsidiary n (mg/L) implemented approved pollutants outlets (t/a) (mg/L) (t/a) Chemical 54.8 500 3.2 41.65 Nil oxygen demand Master outlet in Ammonia 1 sewage treatment 0.99 45 0.06 3.75 Nil nitrogen workshop Total nitrogen 6.09 70 0.3374 5.83 Nil Haibin Total volatile Intermittent Pharma Discharge outlet of organic 1 0.42 100 0.0013 0.50 Nil process exhaust gas compounds Discharge outlet of Non-methane 1 exhaust gas in 11.27 60 0.87 5.04 Nil hydrocarbon sewage station 99 Joincare Pharmaceutical Group Annual Report 2022 iv Xinxiang Haibin Name of Pollutant Total Number Total Name of major Discharge discharge amount of Mode of of Number of amount of Excessive company or pollutants and concentration standards discharge discharge discharge discharge outlets discharge discharge subsidiary specific (mg/L) implemented approved outlets (t/a) pollutants (mg/L) (t/a) Chemical oxygen Master outlet in 66.01 220 9.8 14.81 Nil Xinxiang demand Continuous 1 sewage treatment Haibin Ammonia workshop 5.22 35 0.78 1.66 Nil nitrogen v Fuzhou Fuxing Name of Pollutant Total Number Name of major Discharge discharge Total amount of Mode of of Number of discharge Excessive company or pollutants concentration standards amount of discharge discharge discharge outlets discharge subsidiary and specific (mg/L) implemente discharge (t) approved outlets pollutants d (mg/L) (t/a) Chemical oxygen demand 16.59 100 19.41 102.19 Nil Fuzhou The northwest side Intermittent 1 Fuxing (COD) of the factory Ammonia 0.22 15 0.255 10.22 Nil nitrogen Note: The discharge concentration represents the actual discharge concentration. The standards implemented represent the standards for discharge to the environment by Jiangyin sewage plant (江阴污水处理厂) (i.e. COD ≤100mg/L, ammonia nitrogen ≤15mg/L), and the agreed standard for discharge of COD and ammonia nitrogen from the company to Jiangyin sewage plant shall be ≤500mg/L and ≤60mg/L, respectively. The data was obtained from Fuqing Environmental Protection Bureau. vi Livzon Xinbeijiang Name of Pollutant Total Number Total Name of major Discharge discharge amount of Mode of of Number of discharge amount of Excessive company or pollutants and concentration standards discharge discharge discharge outlets discharge discharge subsidiary specific (mg/L) implemente approved outlets (t) pollutants d (mg/L) (t/a) Chemical oxygen 88.3 240 70.95 213.6 Nil Livzon Sewage treatment demand Intermittent 1 Xinbeijiang workshop Ammonia 3.3 70 2.69 24.5 Nil nitrogen Note: The discharge concentration represents the concentration of discharge into Qingyuan Henghe Sewage Treatment Plant (清远横荷污水处理厂), while the standard adopted for discharge represents the standard stipulated in the pollutant discharge license of the company, i.e. COD ≤240mg/L, ammonia nitrogen ≤70mg/L. The data was obtained from Qingyuan Environmental Protection Bureau. vii Livzon Hecheng Pollutant Name of Total Number Discharge discharge Total Name of major Number of amount of Mode of of concentration standards amount of Excessive company or pollutants and discharge discharge discharge discharg (mg/L)/(mg/ implemented discharge discharge subsidiary specific outlets approved e outlets m3) (mg/L)/(mg/ (t) pollutants (t/a) m3) Chemical oxygen 120 192 15.37 26.68 Nil Wastewater demand Intermittent 1 treatment Ammonia station nitrogen 1.78 40 1.38 5.48 Nil (NH3-N) Sulfur 3 Boiler room 3 50 0.125 / Nil Livzon dioxide Hecheng Nitrogen 3 Boiler room 74.85 150 2.051 / Nil oxide Organized Particulate continuous 3 Boiler room 1.43 20 0.034 / Nil matter emission Hydrogen 7 Workshop 2.29 100 0.829 / Nil chloride Non-methane 7 Workshop 11.41 60 7.551 77.76 Nil hydrocarbon 100 Joincare Pharmaceutical Group Annual Report 2022 Non-methane 1 RTO 5.25 60 0.815 Nil hydrocarbon Nitrogen 1 RTO 30 200 2.278 / Nil oxide Sulfur 1 RTO 3 200 0.467 / Nil dioxide Notes: 1. The discharge concentration of pollutants in waste water represents the average concentration by online monitoring from the master discharge outlet by the company into South District Sewage Treatment Plant, while the standard adopted for discharge represents the standard stipulated in the pollutant discharge license of the company, i.e. COD ≤192mg/L, ammonia nitrogen ≤40mg/L. 2. The discharge concentration of pollutants in the discharge outlet of waste gas represents the average concentration detected by a qualified third party engaged, of which the boiler exhaust adopted the Emission Standard for Boiler Atmospheric Pollutants in Guangdong Province (DB 44/765-2019) (《广东省锅炉大气污染物排放标准》(DB 44/765-2019)). The workshop and wastewater treatment station emission complied with the “Air Pollutant Discharge Standards for Pharmaceutical Industry” (《制药工业大气污染物排放标准》) (GB 37823-2019). viii Gutian Fuxing Name of Pollutant Total Number Name of major Number of Discharge discharge Total amount amount of Mode of of Excessive company or pollutants discharge concentration standards of discharge discharge discharge discharge discharge subsidiary and specific outlets (mg/L) implemented (t) approved outlets pollutants (mg/L) (t/a) Chemical oxygen Southeastern 46.37 120 11.274 108 Nil Gutian demand Continuous 1 part of the Fuxing Ammonia factory zone 9.80 35 2.381 31.5 Nil nitrogen Note: The discharge concentration represents the concentration of ultimate discharge into the environment, while the standard adopted for discharge represents the standard stipulated in the pollutant discharge license of the company, i.e. COD ≤120mg/L, ammonia nitrogen ≤35mg/L. ix Livzon Limin Name of Pollutant Total Number Name of major Number of Discharge discharge Total amount amount of Mode of of Excessive company or pollutants and discharge concentratio standards of discharge discharge discharge discharge discharge subsidiary specific outlets n (mg/L) implemented (t) approved outlets pollutants (mg/L) (t/a) Chemical oxygen Wastewater 19.00 110 4.86 Nil Nil Livzon demand Intermittent 1 treatment Limin Ammonia station 0.51 15 0.14 Nil Nil nitrogen Note: The wastewater of Livzon Limin was discharged into Shaoguan Second Sewage Treatment Plant (韶关市第 二污水处理厂) and the standard adopted for pollutant discharge represented the standard stipulated in the pollutant discharge license of the company, i.e. COD ≤110mg/L, ammonia nitrogen ≤15mg/L, while the data detected by third party inspection was adopted as the discharge concentration. x Livzon Pharmaceutical Factory Name of Pollutant Total Number Name of major Number of Discharge discharge Total amount of Mode of of Excessive company or pollutants discharge concentration standards amount of discharge discharge discharge discharge subsidiary and specific outlets (mg/L) implemented discharge (t) approved outlets pollutants (mg/L) (t/a) Chemical Wastewater oxygen 1 treatment 17.65 120 2.22 Nil Nil Livzon demand station Pharmaceutical Intermittent Wastewater Factory Ammonia 1 treatment 0.10 20 0.012 Nil Nil nitrogen station Note: The discharge concentration of pollutants in the wastewater discharge outlet represents the average concentration detected by a qualified third party engaged, by implementing the strictest of Schedule 2 Water Pollutant Discharge Concentration Limits for Newly-Built Enterprises (表 2 新建企业水污染物排放浓度限值) of the Emission Standard for Pharmaceutical Industrial Water Pollutants from Mixing and Formulation Category (《混 装制剂类制药工业水污染物排放标准》) (GB 21908-2008), Schedule 2 Water Pollutant Discharge Concentration Limits for Newly-Built Enterprises ( 表 2 新建企业水污染 物 排放浓度 限值 ) of “Discharge Standards for Biopharmaceutical Industrial Wastewater” (《生物工程类制药工业水污染物排放标准》) (GB 21907-2008), and 101 Joincare Pharmaceutical Group Annual Report 2022 the level 1 of phase II standard of “Guangdong Provincial Capping on Polluted Effluents Discharge” (《广东省水 污染物排放限值》) (DB44/26–2001). xi Ningxia Pharmaceutical Pollutant Total Name of Total Number discharge amount Name of major Number of Discharge amount Mode of of standards of Excessive company or pollutants and discharge concentration of discharge discharge implemented discharge discharge subsidiary specific outlets (mg/L)/(mg/m3) discharge outlets (mg/L)/(mg/ approved pollutants (t) m3) (t/a) Chemical Sewage oxygen treatment 108 200 110.47 Nil Nil demand workshop on 1 the north side Ammonia of the factory 0.6 25 0.74 Nil Nil nitrogen zone Sulfur 92 200 24.46 156.816 Nil dioxide Boiler Ningxia Nitrogen workshop on Continuous 1 138 200 72.72 156.816 Nil Pharmaceutical oxide north side of Particulate factory zone 14 30 6.11 23.522 Nil matter 4 outlets for fermentation, 3 Volatile outlets for organic 9 2.2 100 5.38 79.535 Nil refinery and 2 compounds outlets for sewage Notes: 1. The discharge concentration of wastewater represents the concentration of ultimate discharge to the environmental protection control center of Ningxia Xin'an Technology Co., Ltd. (宁夏新安科技有限公司) (“Xin'an Company”). The standard adopted for pollutant discharge was the standard stipulated in the pollutant discharge license of the company and the amount of discharge was calculated by the amount received by Xin'an Company. In respect of the total amount of approved discharge, since Ningxia Pharmaceutical adopted indirect discharge, the local government of Ningxia cancelled the limitation of total discharge of chemical oxygen demand and ammonia nitrogen of all indirect discharge enterprises, and the total amount index was directly allocated to sewage treatment plants in the pharmaceutical industrial park established by the government after the renewal of the pollution discharge license. 2. The emission concentration of boiler exhaust gas represents the self-monitoring average concentration throughout the year, the standard adopted for discharge was the standard stipulated in the pollutant discharge license of the company and the amount of discharge was calculated by the amount indicated by online monitoring. The concentration of volatile organic compounds (VOCs) represents the concentration of ultimate discharge to the environment (self-monitoring concentration). The adopted standard was the standard limits stipulated in Schedule I of the “Air Pollutant Discharge Standards for Pharmaceutical Industry” (《制药工业大气污染物排放标准》) (GB37823-2019) and the amount of discharge was calculated by the amount of exhaust gas emissions and the discharge concentration recorded by the monitoring report. xii Jiaozuo Hecheng Name of Pollutant Total Number Name of major Number of Discharge discharge Total amount of Mode of of Excessive company or pollutants and discharge concentratio standards amount of discharge discharge discharge discharge subsidiary specific outlets n (mg/L) implemented discharge (t) approved outlets pollutants (mg/L) (t/a) Chemical Master outlet in oxygen 99.213 220 8.037 60.8 Nil Jiaozuo industrial demand Continuous 1 Hecheng wastewater Ammonia workshop 3.483 35 0.281 8.8 Nil nitrogen Note: The discharge concentration and the total amount of discharge represent the concentration and total amount of ultimate discharge into the downstream sewage treatment plant, and the source is online monitoring data. xiii Shanghai Livzon Name of Pollutant Total Number Discharge Name of major Number of discharge Total amount amount of Mode of of concentration Excessive company or pollutants discharge standards of discharge discharge discharge discharge (mg/L)/(mg/ discharge subsidiary and specific outlets implemented (t) approved outlets m3) pollutants (mg/L)/(mg/m3) (t/a) Chemical Shanghai Master outlet oxygen Intermittent 1 39.92 50 3.30 6.291 Nil Livzon in the park demand 102 Joincare Pharmaceutical Group Annual Report 2022 Ammonia 4.72 5-8 0.38 0.923 Nil nitrogen No. 5 and 6 Particulate 2 outlets on the - - 0.008 0.054 Nil matter Organized roof intermittent No.1, 2, 3, 4, Volatile discharge 7, 8, 9 and 10 organic 8 1.35 60 0.03 0.82 Nil outlets on the compounds roof Note: The discharge concentration was the average of monthly third-party monitoring data, and the amount of discharge was the cumulative sum of monthly discharge. The discharge of VOCs and particulate were in accordance with the “Air Pollutant Discharge Standards for Pharmaceutical Industry” (《制药工业大气污染物排放标准》) (GB37823-2019), and the discharge of COD and Ammonia nitrogen were implemented in accordance with the comprehensive sewage discharge standard DB31/199-2018. Shanghai Livzon was among other key pollutant discharge units, but not among the key pollutant discharge units of water environment and atmospheric environment. xiv Livzon MAB Name of Pollutant Total Number Name of major Number of Discharge discharge Total amount of Mode of of Excessive company or pollutants and discharge concentratio standards amount of discharge discharge discharge discharge subsidiary specific outlets n (mg/L) implemented discharge (t) approved outlets pollutants (mg/L) (t/a) Chemical Wastewater oxygen 1 treatment 17.65 120 2.88 Nil Nil Livzon demand station Intermittent MAB Wastewater Ammonia 1 treatment 0.10 20 0.016 Nil Nil nitrogen station Note: The discharge concentration of pollutants in the wastewater discharge outlet represents the average concentration detected by a qualified third party engaged, by implementing the strictest of Schedule 2 Water Pollutant Discharge Concentration Limits for Newly-Built Enterprises (表 2 新建企业水污染物排放浓度限值) of the “Emission Standard for Pharmaceutical Industrial Water Pollutants from Mixing and Formulation Category” (《混装制剂类制药 工业水污 染物排放标准》) (GB 21908-2008), Schedule 2 Water Pollutant Discharge Concentration Limits for Newly-Built Enterprises (表 2 新建企业水污染物排放浓度限值) of “Discharge Standards for Biopharmaceutical Industrial Wastewater” (《生物工程类制药工业水污染物排放标准》) (GB 21907-2008), and the level 1 of phase II standard of “Guangdong Provincial Capping on Polluted Effluents Discharge” (《广东省 水污染物排放限值》) (DB44/26–2001). xv Sichuan Guangda Name of Pollutant Total Number Total Name of major Number of Discharge discharge amount of Mode of of amount of Excessive company or pollutants and discharge concentratio standards discharge discharge discharge discharge discharge subsidiary specific outlets n (mg/L) implemented approved outlets (t) pollutants (mg/L) (t/a) Chemical oxygen Wastewater 35.85 500 3.26 Nil Nil Sichuan demand Intermittent 1 treatment Guangda Ammonia station 1.61 45 0.15 Nil Nil nitrogen Note: The wastewater of Sichuan Guangda was discharged into Pengzhou First Sewage Treatment Plant (彭州市第 一污水处理厂) and the standard adopted for pollutant discharge represented the standard stipulated in the pollutant discharge license of the company, i.e. COD ≤500mg/L, ammonia nitrogen ≤45mg/L, while the discharge concentration of pollutants in the wastewater discharge outlet represents the average concentration detected by a qualified third party engaged. 2. Construction and operation of pollution preventive facilities √ Applicable □ N/A Name of company or Construction and operation of pollution preventive facilities subsidiary Exhaust gas: The treatment process of “water spray + acid spray + alkali spray + mist eliminator + dry filter + adsorption concentrator + RCO” + “secondary alkali spray” Jiaozuo Joincare was adopted for fermentation exhaust gas. The treatment process of “bag type dust collector” was adopted for proportioning process dust-laden exhaust gas. The treatment process of “secondary alkali spray” was adopted for exhaust gas treatment 103 Joincare Pharmaceutical Group Annual Report 2022 facilities in wastewater treatment station. The treatment process of “alkali adsorption” was adopted for process acid waste gas. The treatment process of “tertiary finned condenser + bag type dust collector + secondary alkali spray + RTO”/“-20 ℃ condensation + activated carbon adsorption device (including regenerating device) + RTO”/“adsorption device (including regenerating device) Jiaozuo Joincare + secondary alkali spray + biological uptake + secondary alkali spray”/“secondary alkali spray + biological uptake + secondary alkali spray” was adopted for process organic exhaust gas. 15 discharge outlets were constructed. All of them enable stable and up- to-standard discharge through self-monitoring in 2022. Wastewater: The treatment process of “regulating pool + hydrolysis acidification pool + UASB + (CASS + air flotation) / modified A/O + secondary settling tank + coagulating sedimentation” was primarily adopted. Standard wastewater outlets were set; online automatic monitoring control system was installed at outlets for real-time monitoring of COD, ammonia nitrogen, total nitrogen, pH, fluorion and flow. Wastewater treatment process sections can be stably operated. Moreover, wastewater control factors can be stably emitted in compliance with the required standard. Pollution preventive facilities functioned properly and ensured up-to-standard Taitai Pharmaceutical discharge. A set of laboratory exhaust gas treatment system was set up and functioned properly. Haibin Pharma Pollution preventive facilities functioned properly and ensured up-to-standard discharge. Wastewater: The wastewater treatment system with daily processing capacity of 600 tonnes through patented H/O process designed by East China University of Science and Technology started operation in April 2016 and functioned properly in 2022. In March 2022, a set of lift aerator system and a set of magnetic levitation blower were added in the biochemical system, and they have been put into operation and functioning properly at present. A new sewage anaerobic treatment system had been building and is under debugging. The H/O biochemical system increased two nitrification reflux pumps of 100m3/h through upgrading and constantly functioned properly. Exhaust gas: The 40000m/h regenerative oxidation exhaust gas treatment system Xinxiang Haibin designed by Jiangsu Ruiding started operation on 2 November 2019, functioned properly throughout 2022 and was emitted in compliance with the required standard. After reconstruction of dry tail gas self-circulating process, the activated carbon adsorption device designed by Beijing Rixin Daneng Technology Co., Ltd. functioned properly in 2022. After UV photolysis+two-level alkali spray and one-level water spray treatment, the waste gas from biochemical aerobic process of wastewater treatment was emitted in compliance with the required standard. The organic waste gas from the workshop process was recycled by membrane and then by resin, and finally delivered into the RTO waste gas treatment system, it ran normally in 2022. The resin recovery organic waste gas pretreatment facilities were completed and run normally. The company strictly complies with the “Three-Simultaneous” system of environmental protection by collecting and treating “Three Wastes (waste water, exhaust gas and solid waste)” according to requirements, and employs an advanced wastewater treatment process known as “Regulating pool + Hydrolysis acidification tank + Sequencing Batch Reactor Activated Sludge Process (SBR) + Air float”. After the wastewater from production has gone through the above treatment process, all Fuzhou Fuxing indicators are stable and satisfy the discharge standard. After meeting the discharge standards, the wastewater is discharged to Jiangyin sewage treatment plant operated by Fujian Huadong Water Treatment Co., Ltd. (福建华东水务有限公司) via sewage pipe network at the industrial park area for further treatment. In 2022, the waste gas treatment facilities for Fenton pool and regulating pool have been added, and the waste gas was treated by secondary spraying. The “Three Wastes” were collected and treated effectively in strict compliance with the “Three Simultaneous” system. The sewage treatment facilities with an investment amount of over RMB30 million have a designed processing capacity of 3,000t/d and adopt the treatment process of “Pre-treatment + Aerobic pool + Hydrolysis acidification tank + SBR + Catalytic oxidation + Air float”. In the first half of 2022, the third round of environmental protection improvement has been carried out, Livzon Xinbeijiang including replacing biological deodorization boxes of the sewage station, adding spray towers and reinstalling pretreatment waste gas collection pipeline to reduce the fugitive emission of waste gas, which has greatly eliminated the peculiar smell around the sewage station. Mufflers were installed at the air emission outlets of the sewage station and the second fermentation division to reduce the airflow sound of air emissions. Sound-absorbing cotton panels have been used to surround the circulating 104 Joincare Pharmaceutical Group Annual Report 2022 pump and steam compressor of the MVR, which have greatly reduced the noise transmitted by the MVR. Meanwhile, equipment with loud noises has been surrounded by sound-absorbing cotton panels to reduce noise and control the generation and transmission of noise from the source. The “Three Wastes” were treated in a centralized and effective manner in strict compliance with the “Three Simultaneous” system and the maintenance and management of pollution preventive facilities were enhanced to ensure that pollutant discharge was stable and in compliance with the required standard. The treatment process of “pre-treatment of drainage from the production process + hydrolytic Livzon Hecheng acidification + Upflow Anaerobic Sludge Bed (UASB) + advanced oxidation + Cyclic Activated Sludge System (CASS) process + air floatation/ozonation advanced treatment” was adopted. Treated sewage was discharged through the municipal sewage pipeline network into Zhuhai Leaguer Environmental Protection Co., Ltd. (珠海力合 环保有限公司) (water purification plant in the South District). At the same time when the enterprise started production, the “Three Wastes” were collected and treated effectively in accordance with the requirements of the “Three Simultaneous” system of environmental protection. This involves a designed sewage treatment capacity of 1,200 t/d, adoption of the advanced “Anarerobic-Oxic activated sludge process (A/O) + SBR + nitrogen removal by denitrification + Fenton decolorizing + air flotation” wastewater treatment process, 6,000 m3 of effective reservoir capacity of the treatment system and more than 20 sets of treatment Gutian Fuxing equipment with 350 KW installed capacity to improve the water treatment process, thus ensuring that all wastewater treatment indicators are stable and satisfy the discharge standard. Treated sewage that reaches the grade II discharge standard is directly discharged into Minjiang River. The hazardous waste of the company is entrusted to qualified companies for compliant disposal according to the requirements of environmental impact assessment and acceptance inspection opinions. In 2022, boiler air pollutant treatment facilities were upgraded and reconstructed. The “Three Simultaneous” system was strictly implemented by the company for the treatment of “Three Wastes” by collecting and treating the “Three Wastes” effectively. The original sewage treatment plant with an investment amount of over RMB13 million has a designed processing capacity of 1,500t/d and adopts the treatment process of “Pre-treatment + Hydrolysis acidification tank + Facultative tank + Aerobic pool + Secondary sedimentation”, and the sewage after treatment was discharged Livzon Limin through the municipal pipeline network into Shaoguan Second Sewage Treatment Plant (韶关市第二污水处理厂). In respect of waste gas treatment, biomass boilers were all replaced by gas boilers. The technical transformation project of the R&D center has installed waste gas treatment facilities such as activated carbon adsorption and acid mist spray tower. In respect of control of noise pollution, investment was made to construct noise segregation wall to reduce noise pollution. The “Three Simultaneous” system was strictly implemented by the company for the treatment of “Three Wastes” by collecting and treating the “Three Wastes” effectively. For wastewater: an investment of over RMB10 million was made for phase I and phase II sewage treatment station with a designed processing capacity of 1,000t/d, which Livzon adopted the CASS process for phase I and the A/O process for phase II, and the sewage Pharmaceutical after treatment was discharged through the municipal pipeline network into sewage Factory treatment plants. For waste gas: currently, the company uses purchased steam and takes the boilers as backups, greatly reducing air emissions. The waste gas of the wastewater treatment stations is treated by a combination of first-level spray towers, Ultra Violet (UV) photoion equipment and second-level spray towers. Through strict enforcement of the “Three Simultaneous” system, the “Three Wastes” were collected and treated effectively. The designed total processing capacity of sewage treatment was 7,500 m3/d (including one plant with capacity of 5,000 m3/d and one plant with capacity of 2,500 m3/d), and the actual total treatment amount was 3,100 m3/d. Treated sewage that reaches the standard stipulated in the pollutant discharge license is discharged to Xin’an Company through the sewage pipeline network in the industrial park. In 2021, the installation and use of waste gas collection and treatment Ningxia facilities for hazardous waste stations were completed, and doramectin fermentation Pharmaceutical waste gas of fermentation workshop 101 was introduced into the specific waste gas treatment facilities for doramectin fermentation waste gas of fermentation workshop 102, and a primary sedimentation tank was added to the sewage treatment station to lead out waste gas for treatment. In 2022, the construction of the following pollution prevention and control facilities was mainly completed: 1. Construction of the exhaust sampling port and sampling platform of the waste gas collection and treatment facility in the hazardous waste storage vault; 2. Renovation of the fresh air supply facility in the bacteria residue crushing room. The original fresh air supply fan installed in the 105 Joincare Pharmaceutical Group Annual Report 2022 middle of the wall was moved to the bottom of the wall, and installation of a new fresh air supply fan; 3. Upgrade and improvement of the original waste gas treatment facilities in 103-2 fermentation workshop, mainly including a new set of "sodium hypochlorite spray absorption + water spray absorption + biphasic superoxide water + micro-nano bubbles" process treatment facilities; 4. Construction of anti-leakage facilities in the emergency pool of hazardous chemicals warehouse; 5. Replacement of damaged cover plate of sludge storage tank; 6. reseal the cover plate of the sewage treatment pre-aeration tank and seal and repair of the water-sealing groove of the cover plate of the sedimentation tank, sealing the original cover plate of the pre-aeration tank integrally with glass fiber cloth and epoxy resin, applying paint on the rusted pipeline, and welding and plugging the damaged part of the water-seal groove of the cover plates of original sedimentation tank; 7. the construction of rainwater and sewage diversion facilities in the plant area, and laying and installing rainwater collection pipe network facilities with a total length of about 1,000 meters. The “Three Wastes” were collected and treated effectively in strict compliance with the “Three Simultaneous” system. The designed sewage treatment capacity was 3,000t/d, the treatment process of “hydrolytic acidification tank + UASB + aerobic pool + materialized treatment” was adopted, the treated wastewater would be discharged through the municipal pipeline network into the sewage treatment plant of Xiuwu Branch of Kangda Water Co., Ltd. (康达水务有限公司修武分公司). The sewage treatment facilities were under normal operation with compliant discharge. For waste gas: in 2021, the three-stage sewage spraying was replaced, and a set of waste gas treatment facilities was added in the UV photolysis sewage station. Waste gas would be discharged after standard was met. Waste gas generated from technical process in the production zone would be collected and treated by adopting two sets of processes of “water spray + activated carbon and -20℃ condensation + water spray + activated carbon” and then discharged after reaching the required standard. Solid waste and hazardous waste would be stored in the hazardous waste station constructed in compliance with the requirements of “Three Protections” (protection against leaks, erosion and rain) according to the requirements under the (Pilot) Guidelines for Standardized Management of Hazardous Waste in Henan Province (《河南省危险废 Jiaozuo Hecheng 物规范化管理工作指南(试行)》) for hazardous waste. In January 2022, a self- monitoring and automatic monitoring equipment comparison contract was signed with Henan Zhongfang Quality Inspection Technology Co., Ltd. (河南中方质量检测技术 有限公司) to monitor the company’s discharge outlets on a regular basis; in January 2022, an operation and maintenance contract in relation to online continuous monitoring system for water quality was signed with Jiaozuo Lansheng Environmental Technology Service Co., Ltd. (焦作市蓝晟环保技术服务有限公司) to maintain the water quality by the company’s online continuous monitoring system. In April 2022, the company entered into a hazardous waste disposal agreement with Henan Zhonghuanxin Environmental Technology Co., Ltd. (河南中环信环保科技有限公 司) for disposal of hazardous waste on regular basis. Other general solid waste would be disposed of in compliance with the relevant requirements. In March 2022, we signed a wastewater discharge water quality standard agreement with Kangda Environmental Protection Water Co., Ltd. (康达环保水务有限公司) Xiuwu Branch, and in the same month, we signed an LDAR test agreement with Shandong Xianglong Environmental Testing Co., Ltd. In July 2022, we signed a gas online operation and maintenance contract with Jiaozuo City Kailin Environmental Protection Technology Co., Ltd. (焦作市凯霖环保科技有限公司). The company designed and built a sewage treatment station with a processing capacity of 200 m3/d in 2018. The company’s wastewater was treated by such sewage treatment station and then entered the park’s sewage treatment station for secondary treatment, and finally discharged into the municipal pipeline network. The company had the hazardous waste station in compliance with the requirements of “Three Preventions” to store hazardous waste and appointed a qualified company for compliant disposal. Shanghai Livzon The company’s main discharge outlets were treated with activated carbon adsorption and filtration, and the activated carbon was replaced every half a year to ensure that the air emissions met the standards. In January 2022, the company demolished the solid preparation workshop on the third floor and transformed it into a microsphere workshop, and there is no particulate matter emission from the No. 5 and No.6 discharge outlets accordingly. The “Three Simultaneous” system was strictly implemented by the company for the treatment of “Three Wastes” by collecting and treating the “Three Wastes” effectively. Livzon MAB For wastewater (relying on the wastewater treatment of Pharmaceutical Factory in the park): an investment of over RMB10 million was made for phase I and phase II sewage 106 Joincare Pharmaceutical Group Annual Report 2022 treatment station with designed processing capacity of 1,000t/d, which adopted the CASS process for phase I and the A/O process for phase II, and the sewage after treatment was discharged through the municipal pipeline network into sewage treatment plants. For waste gas: currently, the company uses purchased steam and takes the boilers as backups, greatly reducing air emissions. The waste gas of the wastewater treatment stations is treated by a combination of first-level spray towers, Ultra Violet (UV) photoion equipment and second-level spray towers. The “Three Simultaneous” system was strictly implemented by the company for the treatment of “Three Wastes” by collecting and treating the “Three Wastes” effectively. For wastewater (relying on the wastewater treatment station with an investment of over RMB5 million and designed processing capacity of 400t/d, which adopted the process of “Regulating pool+Anaerobic pool+Aerobic pool+Air float” forsewage treatment, Sichuan Guangda the sewage after treatment was discharged through the municipal pipeline network into Pengzhou No.1 Sewage Treatment Plant (彭州市第一污水处理厂). For waste gas: currently, the company adopts biomass boiler with "cyclone + cloth bag +SNCR+SCR" to treat the waste gas produced. The waste gas of sewage station is treated by alkali washing spray. 3. Environmental impact assessment of construction projects and other environmental protection administrative licensing √Applicable □N/A Name of company or Environmental impact assessment of construction projects and other subsidiary environmental protection administrative licensing The Approval of Environmental Impact Report on New 12T Natural Gas Boiler Project for Jiaozuo Joincare Pharmaceutical Industry Co., Ltd. (Jiao Huan Shen Ma [2022] No. Jiaozuo Joincare 2) was granted on 11 May 2022. The environmental protection inspection for the new boiler project was carried out on 26 October 2022. The environmental impact assessment report of new products was under the stage of Taitai Pharmaceutical preparation and approval. No environmental impact assessment project was required in 2022; with strict enforcement of the “Three Simultaneous” system in the production process and implementation of the environmental protection measures required under the Haibin Pharma environmental impact assessment, the environmental protection facilities have been functioning properly; the change of pollutant discharge license was applied for and obtained approval in November 2022. Approval of Environmental Impact Report on 20 Tonnes/Year Meropenem Pharmaceutical Intermediate Project (Yu Huan Jian [2005] No. 84), Opinions on Environmental Protection Inspection and Acceptance for 20 Tonnes/Year Meropenem Pharmaceutical Intermediate F9 Project (Yu Huan Bao Yan [2008] No. 89), Approval of Environmental Impact Report on 100 Tonnes/Year Meropenem Pharmaceutical Intermediate Expansion Project (Yu Huan Shen [2014] No. 564), Independent acceptance of Approval of Environmental Impact Report on 100 Tonnes/Year Xinxiang Haibin Meropenem Pharmaceutical Intermediate Expansion Project on 24 March 2019, and Opinions of Comprehensive Supervision and Enforcement Bureau of High-tech Zone on Approval of Environmental Impact Report on Technical Center Expansion Project of Xinxiang Haibin Pharmaceutical Co., Ltd. (Xin Gao Zong Jian Zi [2020] No. 26). The reply to the Environmental Impact Assessment Report for the Peinan Series API Development Project of Xinxiang Haibin Pharmaceutical Co., Ltd (Xin Huan Shu Shen [2021] No. 24) was received. The Environmental Impact Report on the Phase III High-end Antibiotics Project of Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd. was approved on 23 August 2021. The company strictly implements the “Three Simultaneous” system and takes environmental protection measures required for environmental assessment, with the environmental protection facilities under normal operation. Approval was granted for Fuzhou Fuxing the application of a new national pollutant discharge license on 27 December 2017 and the renewal of the national pollutant discharge license was completed in December 2020. The company has been discharging pollutants in strict compliance with the licensing and administrative requirements. The Environmental Impact Report on the Phase IV High- end Antibiotics Project of Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd. was approved on 12 October 2022. The “Environmental Impact Report on Current Status of Projects of Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.” (《(丽珠集团新北江制药股份有限 Livzon Xinbeijiang 公司项目现状环境影响报告书》) was approved and filed on 6 December 2016. With strict enforcement of the “Three Simultaneous” system and implementation of the 107 Joincare Pharmaceutical Group Annual Report 2022 environmental protection measures required under the environmental impact assessment, the environmental protection facilities have been functioning properly. On 29 December 2017, an approval was granted for the application of a new national pollutant discharge license. The environmental protection policies were strictly enforced. On 28 April 2022, the company completed the application for the pollutant discharge license for Shijiao New Factory. On 16 June 2022, the company completed the environmental impact assessment of the new plant for the addition of mixed compound veterinary drugs and obtained the environmental assessment approval (Qingcheng Shen Pi Huan Biao [2022] No. 12). The work for changing and renewing the pollutant discharge license was completed in December 2022. The “Environmental Impact Assessment Report on Current Status of the Product Structure and Production Capacity Adjustment Project of Zhuhai FTZ Livzon Hecheng Pharmaceutical Manufacturing Co., Ltd.” (《珠海保税区丽珠合成制药有限公司产品 结构及产能调整项目现状环境影响评价报告》) was approved in December 2016. In 2021, the environmental impact assessment of 14 new products including paliperidone palmitate (棕榈酸帕利呱酮), aripiprazole (阿立哌唑), bismuth potassium citrate (枸橼 酸 铋 钾 ), i.e. the “Environmental Impact Assessment Report on Technological Livzon Hecheng Renovation and Expansion Project of Livzon Synthetic Pharmaceutical Co., Ltd. in Zhuhai Free Trade Zone” (《 珠海保税区丽珠合成制药有限公司技改扩建项目环境 影响评价报告》), passed expert review and was approved on 20 January 2022. The company strictly enforced the “Three Simultaneous” system and implemented environmental protection measures as required under environmental impact assessment with normal operation of the environmental protection facilities. In 2022, it was awarded the green card enterprise of environmental credit rating by Zhuhai Municipal Ecology and Environment Bureau. In March 2022, the company completed the filing of the revised environmental emergency contingency plan. The company passed the environmental impact assessment on 30 June 1999 and the inspection and acceptance upon completion of construction carried out by Environmental Protection Bureau of Fujian Province on 5 June 2000. The company re- prepared its post-environmental impact assessment report in 2019 and passed the inspection and acceptance carried out by experts on 11 June 2019. The company strictly Gutian Fuxing enforced the “Three Simultaneous” system and implemented environmental protection measures as required under environmental impact assessment with normal operation of the environmental protection facilities. The clean production passed the on-site audit and acceptance by the Bureau of Ecology and Environment in September 2022, and the audit and inspection opinion of the Ningde Environmental Science Institute was obtained in October 2022. The “Environmental Impact Report on the Technological Reform Project for the R&D Center of Livzon Group Limin Pharmaceutical Manufacturing Factory” (《丽珠集团利 民制药厂研发中心技改项目环境影响报告表》) was approved on 6 December 2019. The expert meeting of acceptance was held on 24 April 2021, in which the independent acceptance was completed. The “Environmental Impact Report for Workshop II of Small capacity Injection” (《小容量注射剂二车间项目环境影响报告表》) was approved on 23 November 2020. On 15 September 2021, the expert meeting of acceptance was held, in which the independent review was completed. The National Sewage Permit was Livzon Limin updated on 22 October 2021. The “Three Simultaneous” system was strictly enforced to implement the environmental protection measures required under the environmental impact assessment, and the environmental protection facilities were under normal operation. In September 2022, Limin Pharmaceutical Manufacturing Factory passed the on-site audit of cleaner production by the expert group. In the future, it will continue to tap the potential of energy conservation and emission reduction, establish and improve the cleaner production mechanism, and continuously improve the level of cleaner production. From 2019 to 2022, it was consecutively rated as a green card enterprise by Shaoguan Ecology and Environment Bureau. The Environmental Impact Assessment Report on Expansion Project for Production Line of Recombinant Human Chorionic Gonadotropin for Injection of Livzon Group Livzon Pharmaceutical Factory (丽珠集团丽珠制药厂) was approved in March 2018. The Environmental Impact Assessment Report on Expansion Project for Sewage Treatment Stations of Livzon Group Livzon Pharmaceutical Factory was approved in Livzon Pharmaceutical April 2019. The Environmental Impact Assessment Report on Expansion Project for Factory Production Line of lyophilized Powder Injection of Livzon Group Livzon Pharmaceutical Factory was approved in November 2020. The Environmental Impact Report Form of P07 New Wet Granulation Line Project of Livzon Group Livzon Pharmaceutical Factory was approved on 18 May 2022. The pharmaceutical factory obtained an updated sewage permit in June 2022. The Environmental Impact Report on 108 Joincare Pharmaceutical Group Annual Report 2022 the Project of New Boiler and Low Nitrogen Transformation of Boiler was approved on 19 August 2022. The company will strictly enforce the “Three-simultaneous” system to implement the environmental protection measures as required by environmental assessment. The environmental protection inspection for completion of doramectin expansion project was completed in March 2021. In September 2021, expert review and government filing were completed for the environmental impact evaluation of project work upon optimized disposal of the company’s solid waste. The company applied to change its pollutant discharge permit and passed the review of the Pingluo Branch of Shizuishan Municipal Ecology and Environment Bureau in December 2021. In December 2022, the company passed the certification of Shizuishan municipal green plant and prepared the environmental impact assessment report on the increase in production capacity of Ningxia Pharmaceutical phenylalanine (currently under review by experts). The company reported to the national pollution discharge license management information platform (pollution discharge implementation report) and the ecological environment statistics business system (enterprise environment statistics report) quarterly. In 2022, the second round of rectification of central environmental protection supervision issues, independent acceptance by enterprises and government acceptance were also completed. The company strictly enforced the “Three Simultaneous” system to implement the environmental protection measures as required by environmental assessment, while the environmental protection facilities were under normal operation. The “Environmental Impact Assessment Report on Current Status of Jiaozuo Livzon Hecheng Pharmaceutical Manufacturing Co., Ltd.” (《焦作丽珠合成制药有限公司现 状环境影响评估报告》) was approved and filed on 15 December 2016. The “Three Simultaneous” system was strictly enforced, the environmental protection measures as required by environmental assessment were implemented and the environmental protection facilities were under normal operation. The application for the national Jiaozuo Hecheng pollutant discharge license was completed in December 2020, the environmental protection policies were strictly enforced and various management measures were implemented. According to the spirit of the document “Notice of the Office of the Leading Group of Jiaozuo City’s Pollution Prevention and Control Battle on Doing a Good Job in the Key Work of Air Pollution Prevention and Control in May 2022”, the company formulated the “one policy for one enterprise” plan for Jiaozuo Hecheng VOCs emission enterprise in 2022. In May 2022, the letter of commitment for environmental protection and law-abiding operation of enterprises for 2022 was formulated. The company passed the environmental assessment review of the “Leuprorelin Acetate Microspheres for Injection Industrialization Project” (《注射用醋酸亮丙瑞林微球产 业化项目》) on 11 October 2010, obtained the approval for the “Environmental Impact Report on Supporting Engineering and Laboratory Projects of Shanghai Livzon Shanghai Livzon Pharmaceutical Manufacturing Co., Ltd.” (《上海丽珠制药有限公司配套工程及实验 室项目环境影响报告》 on 10 January 2020, and completed the construction and passed the acceptance inspection in September 2020. The company strictly implemented the “Three Simultaneous” system and took environmental protection measures required for environmental assessment, while the environmental protection facilities were under normal operation. The “Environmental Impact Assessment Report on V-01 Industrialization Project of Livzon Group Livzon Pharmaceutical Factory” (《关于丽珠集团丽珠制药厂 V-01 产 业 化 项 目 环 境 影 响 报 告 书 》 ) was approved in April 2021. The Third Line Environmental Impact Report of the Expanded Preparation of the Large-scale Livzon MAB Production Capacity Construction Project of Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) was approved in March 2022. The company obtained an updated sewage permit in November 2022. The company strictly implemented the “Three Simultaneous” system and took environmental protection measures required for environmental assessment. The “Filing Report of Environmental Impact on the Technical Upgrading Project of Production Line for Chinese Patent Medicine of Sichuan Guangda Pharmaceutical Manufacturing Co., Ltd.” (《四川光大制药有限公司中成药生产线技术改造项目环 Sichuan Guangda 境影响备案报告》) was approved and filed on 27 May 2016, and was granted a national pollutant discharge license on 23 July 2020. The company strictly implemented the “Three Simultaneous” system and took environmental protection measures required for environmental assessment, and the environmental protection facilities were under normal operation. 109 Joincare Pharmaceutical Group Annual Report 2022 4. Environmental emergency contingency plan √ Applicable □ N/A Name of company or Environmental emergency contingency plan subsidiary Revision of the environmental emergency contingency plan of Jiaozuo Joincare was completed in May 2022 and was filed in the Macun Branch of Ecology and Environment Bureau of Jiaozuo City on 19 May 2022. Jiaozuo Joincare Revision of the environmental emergency contingency plan for hazardous waste pollution accident of Jiaozuo Joincare was completed in December 2020, which currently is in effect. Taitai Pharmaceutical Review and filing was completed in July 2020, which currently is in effect. The Environmental Emergency Contingency Plan was filed (File No. 440308-2020- 0029M). Trainings and drills on emergency responses were provided for employees to Haibin Pharma improve the capability of the Company for dealing with environmental emergencies. In 2022, four emergency drills for environmental emergencies were held. Environmental Emergency Contingency Plan of Xinxiiang Haibin Pharmaceutical Co., Xinxiang Haibin Ltd. was filed with the Ecology and Environment Bureau on 23 August 2022 with the file reference number 410771-2022-006-M. Pursuant to relevant provisions and requirements, the “Environmental Emergency Contingency Plan of Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.” (《(丽珠 集团福州福兴医药有限公司突发环境事件应急预案》) was prepared based on the principles of “prevention-oriented, self-help-oriented, unified command, and division of responsibility”, which has been filed on 15 April 2022 (File No. 350181-2022-024-M). After environmental emergencies occur, immediate, quick, effective and orderly Fuzhou Fuxing emergency rescue actions shall be taken to control and prevent the spread of accident and contamination, protect the surrounding environment and safeguard life and property of all employees, the company and nearby communities. In accordance with the contents and requirements of the plan, the company provides trainings and drills for its employees to get them well-prepared for environmental emergencies, so that timely rescue can be taken and the accident can be controlled in a short period of time in case of any environmental emergencies. In May 2022, the second comprehensive emergency drill for four leakage accidents in the workshop was conducted. Based on the principles of “prevention-oriented, on-alert all the time; classified management, level-by-level response; cross-department cooperation, responsibility by levels; scientific prevention and efficient handling”, Livzon Xinbeijiang re-signed and issued the “Environmental Emergency Contingency Plan of Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.” (《(丽珠集团新北江制药股份有限公司突发环境 Livzon Xinbeijiang 事件应急预案》) (File No. 441802-2021-0162-H) on 30 September 2021, which has been approved and filed by Qingyuan Municipal Ecology and Environment Bureau on 22 October 2021. Livzon Xinbeijiang conducted exercises regularly to identify environmental factors and sources of hazards, as well as drills on the emergency contingency plan. An environmental emergency contingency drill was conducted in June 2022 to improve the operability thereof, and enhance the performance of the emergency rescue staff and the responsiveness and coordination ability of the rescue team. Pursuant to relevant provisions and requirements, the “Environmental Emergency Contingency Plan of Zhuhai FTZ Livzon Hecheng Pharmaceutical Manufacturing Co., Ltd.” (《(珠海保税区丽珠合成制药有限公司突发环境事件应急预案》) was prepared based on the principles of “Focus on Prevention, Aim at Self-rescue, Centralized Command, and Division of Responsibility”, which has been approved, filed and issued Livzon Hecheng (File No. 440462-2019-001-M). Trainings on emergency response and handling measures were held regularly for employees to enable implementation of safety measures in a timely, fast, effective and orderly manner to control and prevent the spread of accident and contamination when encountering any environmental emergencies, so as to alleviate or eliminate the impact of the accident and resume production as soon as possible. Pursuant to relevant provisions and requirements, the “Environmental Emergency Contingency Plan of Gutian Fuxing Pharmaceutical Co., Ltd.” (《古田福兴医药有限公 司突发环 境事 件应急 预案》 ) was prepared based on the principles of “Focus on Prevention, Aim at Self-rescue, Centralized Command, and Division of Responsibility”. Gutian Fuxing The contingency plan was approved in May 2017 (File No. 352200-2017-005-L) and amended in June 2020, and has passed expert review and completed filing (File No. 350922-2020-002-M). According to the plan, the company conducted emergency drill for sudden hydrochloric acid leakage in September 2022. After environmental emergencies occur, immediate, quick, effective and orderly emergency rescue actions shall be taken to control and prevent 110 Joincare Pharmaceutical Group Annual Report 2022 the spread of accident and contamination, and to protect the surrounding environment and safeguard life and property of all employees, the company and nearby communities. In accordance with the content and requirements of the plan, the company provides trainings for its employees to get them well-prepared for environmental emergencies, so that timely rescue can be taken and the accident can be controlled in a short period of time in case of any environmental emergencies. The principles of occupational health and safe environment administrative system were followed, including occupational protection to ensure health, risk control to ensure safety, prevention and control of pollution to protect the environment, and compliance with discipline and law for continuous improvement. Identification of environmental factors was performed seriously and preventive measures were adopted for significant environmental factors, while the governance of the “Three Wastes” was strengthened to enhance the ability of control over the “Three Wastes” and ensure that the discharge of the “Three Wastes” had reached the discharge standards. The “Environmental Emergency Contingency Plan of Livzon Group Limin Pharmaceutical Manufacturing Factory” (《丽 Livzon Limin 珠集团利民制药厂突发环境事件应急预案》) was prepared in accordance with the criteria of the environmental management system and the occupational health and safety administrative system. The plan was issued in May 2021 (File No. 440203-2021-009-L). According to the contingency plan, an environmental accident emergency drill was conducted on 24 September 2021, and a specific drill summary was made. Identification of environmental factors and sources of hazards and drills for emergency were conducted internally in the company on a regular basis to improve the operability of the contingency plan, and enhance the performance of the emergency rescue staff and the responsiveness and coordination ability of the rescue team. Pursuant to relevant provisions, the “Environmental Emergency Contingency Plan of Livzon Group Livzon Pharmaceutical Factory” (《丽珠集团丽珠制药厂突发环境事件 应急预案》) was reformulated by the company in 2021, and has been approved, filed and issued (File No. 440404-2021-0212-L). The company conducted a fire emergency evacuation drill in the P10 workshop in April 2022 to improve employees’ emergency Livzon Pharmaceutical handling ability and to alleviate or eliminate the impact of the accident. On 21 October Factory 2022, the special emergency drill for alcohol leakage (causing fire and explosion) was carried out to provide training to the emergency response team, thus enhancing the emergency execution and disposal ability of the emergency drill participants, further clarifing the responsibilities and tasks of relevant personnel, and improving the emergency linkage mechanism. The company improved the awareness of risk prevention and the ability of self-rescue and mutual-rescue. The “Environmental Emergency Contingency Plan of Livzon Group (Ningxia) Pharmaceutical Manufacturing Co., Ltd.” (《丽珠集团(宁夏)制药有限公司突发环境事 件应急预案》) was approved filed and issued in May 2019 (File No. 640221-2019-005- II). Identification of environmental factors and sources of hazards and drills for emergency Ningxia Pharmaceutical were conducted internally in the company on a regular basis to improve the operability of the contingency plan, and enhance the performance of the emergency rescue staff and the responsiveness and comprehensive coordination ability of the rescue team. The Environmental Emergency Contingency Plan was amended in May 2021, and has passed expert review and the review by and the filing with government environmental department in August 2021. The “Environmental Emergency Contingency Plan of Jiaozuo Livzon Hecheng Pharmaceutical Manufacturing Co., Ltd.” ( 《焦作丽珠合成制药有限公司突发环境事 件应急预案》) was prepared in accordance with the relevant provisions and requirements and based on the principles of “prevention-oriented, on-alert all the time; classified management, level-by-level response; cross-department cooperation, responsibility by levels; scientific prevention and efficient handling”. The contingency plan was approved, issued and filed in April 2021 (File No. 4108042018005L). The “Hazardous Waste Environmental Pollution Emergency Contingency Plan of Jiaozuo Livzon Hecheng Pharmaceutical Manufacturing Co., Ltd.” (《焦作丽珠合成制药有限公司危险废物环境 Jiaozuo Hecheng 污染事故应急预案》) was prepared under the above provisions, requirements and principles as well, which was approved and filed in January 2018. Identification of environmental factors and sources of hazards and drills for emergency were conducted internally in the company on a regular basis to improve the operability of the contingency plan, and enhance the performance of the emergency rescue staff and the responsiveness and coordination ability of the rescue team. The company carried out trainings on the Standard Operating Procedure for Acid Mist Purification Towers and the Standard Operating Procedure for Hazardous Waste Storage Pollutants in April 2021 and June 2021, respectively. According to the relevant requirements of the Hazardous Waste Environmental Pollution Emergency Contingency Plan of Jiaozuo Livzon Hecheng 111 Joincare Pharmaceutical Group Annual Report 2022 Pharmaceutical Manufacturing Co., Ltd. In November 2021, the “Operation Regulations for Exhaust Gas UV Photolysis Equipment” was added and the “Spray Towers Operation Regulations” was amended, and relevant trainings were conducted to increase the environmental protection knowledge of staff. In March 2022, the company amended some environmental protection documents, including the “Enterprise Environmental Information Disclosure System”, “Discharge Permit System” and “Operating Procedures for Sewage Treatment”. In March 2022, the company issued and filed the “Environmental Emergency Contingency Plan of Shanghai Livzon Pharmaceutical Manufacturing Co., Ltd.” (《上海丽珠制药有 Shanghai Livzon 限公司突发环境事件应急预案》) (File No. 02-310115-2022-108-L). The company conducts drills and reviews of the plan every year to improve its emergency response capabilities through such regular trainings. Pursuant to relevant provisions, the “Environmental Emergency Contingency Plan of Livzon MAB” (《丽珠单抗突发环境事件应急预案》) was prepared by the company in Livzon MAB 2022. The company conducted an emergency response drill for hazardous chemical leakage in the dangerous goods warehouse in June 2022 to improve employees’ emergency handling ability and alleviate or eliminate the impact of the accident. The principles of occupational health and safe environment administrative system were followed, including occupational protection to ensure health, risk control to ensure safety, prevention and control of pollution to protect the environment, and compliance with discipline and law for continuous improvement. Identification of environmental factors was performed seriously and preventive measures were adopted for significant environmental factors, while the governance of the “Three Wastes” was strengthened to Sichuan Guangda enhance the ability of control over the “Three Wastes” and ensure that the discharge of the “Three Wastes” had reached the discharge standards. The “Environmental Emergency Contingency Plan of Livzon Group Limin Pharmaceutical Manufacturing Factory” (《(四 川光大製藥有限公司突发环境事件应急预案》 ) was prepared and issued on 23 December 2022. Identification of environmental factors and sources of hazards and drills for emergency were conducted internally in the company on a regular basis. 5. Environmental self-monitoring program √ Applicable □N/A Name of company or Environmental self-monitoring program subsidiary As required by the self-monitoring program for pollutant discharge licenses, Jiaozuo Joincare developed the 2022 self-monitoring program for wastewater and waste gas and carried out self-monitoring according to the program. Up to the end of December, Jiaozuo Joincare has completed the self-monitoring for wastewater and waste gas for the year of 2022. Jiaozuo Joincare The company is a key enterprise in terms of soil monitoring, and should carry out self- monitoring of soil once a year as required. In August 2022, the company has completed the preparation, on-site sampling and review of self-monitoring program and published on the website of the Group on 26 August 2022. Wastewater was monitored once a quarter; boiler exhaust gas and plant boundary noise were monitored once a year; exhaust gases generated from technical process was monitored once Taitai Pharmaceutical half a year; online monitoring facilities of wastewater and boiler exhaust gas were additionally installed and functioning well. A third party is entrusted to conduct regular monitoring strictly in compliance with the relevant national laws and regulations and local requirements and ensure the accuracy, validity and authenticity of the monitoring data. Online wastewater monitoring equipment was installed Haibin Pharma and connected to environmental monitoring stations at municipal and district levels in accordance with environmental monitoring technical standards. Data was promptly uploaded on the national monitoring platform. A self-monitoring program was prepared, the annual self-monitoring of exhaust gas, Xinxiang Haibin wastewater and soil has been completed throughout the year in accordance with the pollutant discharge license. According to the relevant requirements of the “Measures for Self-Monitoring and Information Disclosure by Enterprises subject to Intensive Monitoring and Control of the State (Trial Implementation)” (《国家重点监控企业自行监测及信息公开办法 (试行)》) and the Fuzhou Fuxing “Technical Guidelines for Self-Monitoring by Pollution Discharge Enterprises in the Fermentation Pharmaceutical Industry (HJ882-2017)” (《排污单位自行监测技术指南发酵 类制药工业(HJ882-2017)》), the company has completed the establishment of the self- monitoring program based on its own situation in a timely manner and made the program 112 Joincare Pharmaceutical Group Annual Report 2022 available to the public after being examined by and filed with Fuqing Environment Protection Bureau and Fuzhou Environment Protection Bureau. The analysis methods of the monitoring program comply with the national environmental monitoring technical standards and methods; the monitoring and analysis instruments have been examined and calibrated in strict compliance with the relevant national requirements; the automated monitoring equipment has been installed in accordance with the requirements of environmental assessment technical standards, connected to the network of competent environmental protection authorities and passed the acceptance inspection conducted by the competent environmental protection authorities. The automated monitoring equipment was sound, and the monitoring information was accurate, valid and authentic. In June 2022, the volatile organic matters (VOCs) leak detection and repair (LDAR) work in the first half of the year was finished. In November 2022, the volatile organic matters (VOCs) leak detection and repair (LDAR) work in the second half of the year was finished. Information publicity website: http://wryfb.fjemc.org.cn According to the relevant requirements of the “Measures for Self-Monitoring and Information Disclosure by Enterprises subject to Intensive Monitoring and Control of the State (Trial Implementation)” (《国家重点监控企业自行监测及信息公开办法(试行)》), the company has completed the establishment of the self-monitoring program based on its own situation in a timely manner and made the program available to the public after being examined by and filed with Qingyuan Environment Protection Bureau. The analysis methods of the monitoring program comply with the national environmental monitoring technical standards and methods; the monitoring and analysis instruments have been examined and calibrated in strict compliance with the relevant national requirements. The automated monitoring equipment for Livzon Xinbeijiang wastewater (COD, ammonia nitrogen, pH, flow) and waste gas (non-methane hydrocarbons) has been installed in accordance with the requirement of environmental assessment technical standards, while online monitoring equipment has passed the inspection and acceptance of the relevant environmental protection authorities and the connection between online information and national development platform and Qingyuan municipal platform has been completed. The automated monitoring equipment was sound, and the monitoring information was accurate, valid and authentic. A third party is entrusted to conduct LDAR detection and repair every half year in the workshop using VOCs in compliance with the specification requirements. The fugitive volatile organic compounds around the workshop of the first refinery division were monitored every half year, and the monitoring results met the standard in 2022. Through self-monitoring, the requirements under the “Technical Standards for Application and Issuance of Pollutant Discharge License for the Pharmaceutical Industry – Active Pharmaceutical Ingredient Manufacturing (HJ858.1-2017)” (《排污许可证申请与核发技术 规 范 制 药 工 业 - 原 料 药 制 造 ( HJ858.1-2017 ) 》 ) were strictly implemented, and the Livzon Hecheng verification and calibration of monitoring analyzing devices were carried out in strict compliance with relevant provisions and connected with the national development platform as required. In 2022, a third party was entrusted to carry out regular LDAR testing, emission port testing, boundary noise monitoring and soil testing, and the test results were in line with the requirements. According to the relevant requirements of the “Measures for Self-Monitoring and Information Disclosure by Enterprises subject to Intensive Monitoring and Control of the State (Trial Implementation)” (《国家重点监控企业自行监测及信息公开办法(试行)》), the company has completed the establishment of the self-monitoring program based on its own situation in a timely manner and made the program available to the public after being examined by and filed with Ningde Bureau of Ecology and Environment and Ningde Gutian Bureau of Ecology and Environment. The analysis methods of the monitoring program comply with the national environmental monitoring technical standards and methods; the monitoring and analysis Gutian Fuxing instruments have been examined and calibrated in strict compliance with the relevant national requirements; the automated monitoring equipment has been installed in accordance with the requirements of environmental assessment technical standards, connected to the network of competent environmental protection authorities and passed the acceptance inspection conducted by the competent environmental protection authorities. The automated monitoring equipment was sound, and the monitoring information was accurate, valid and authentic. In June and December 2022, a qualified third party was engaged to complete volatile organic matter leak detection and repair (LDAR) and a report was obtained. Information publicity website: http://wryfb.fjemc.org.cn An entity with national qualification on inspection was engaged to conduct monitoring strictly in compliance with the relevant national laws and regulations and standards. In view of its own specific conditions, the company appointed the inspection party to carry out water pollutant detection monitoring every quarter, boiler exhaust gas monitoring every month and VOCs Livzon Limin exhaust gas monitoring in R&D center every half year, with every monitoring strictly in compliance with the relevant national requirements to ensure the accuracy, validity and authenticity of the monitoring data. The inspection acceptance of the online monitoring equipment for COD, ammonia nitrogen water quality was completed and it was put into use in 113 Joincare Pharmaceutical Group Annual Report 2022 January 2021, and the equipment was monitored every 2 hours. The pollution source sharing data were completed and filed to the Shaoguan Ecology and Environment Bureau on a timely basis, and the relevant data were announced to the public after being reviewed by Shaoguan Municipal Bureau Ecology and Environment. An entity with national qualification on inspection was engaged to conduct monitoring strictly in compliance with the relevant national laws and regulations and standards. In view of its own specific conditions, the company appointed the inspection party to carry out monitoring on Livzon Pharmaceutical sewage and waste gas every month, with every monitoring strictly in compliance with the Factory relevant national requirements to ensure the accuracy, validity and authenticity of the monitoring data. The installation and commissioning of the online sewage monitoring equipment was completed and it was put into use at the beginning of 2021. The company formulated the self-monitoring program for 2022, which was reviewed by and filed with the Ecology and Environment Bureau of Shizuishan City. Monthly and quarterly monitoring was carried out strictly in accordance with the requirements of the program, which focused primarily on organized exhaust gas emission, exhaust gas emission from boiler, waste water discharge, underground water, soil, unorganized environmental air monitoring above plant boundary, noise and recycled water TOC. The monitoring results would be announced to the public through the “System of National Pollution Sources Monitoring Information Ningxia Pharmaceutical Management and Sharing Platform” (《全国污染源监测信息管理与共享平台系统》) and the “System of Self-monitoring Information Open Platform for Enterprises in Shizuishan” (《石嘴山市企业自行监测信息公开平台系统》). Volatile organic matter leak detection and repair (LDAR) work was carried out. The automated monitoring equipment passed the inspection conducted by the competent environmental protection authority and was connected to the network of the competent environmental protection authority. The automated monitoring equipment was sound, and the monitoring information was accurate, valid and authentic. According to the relevant requirements of the “Measures for Self-Monitoring and Information Disclosure by the Enterprises subject to Intensive Monitoring and Control of the State (Trial Implementation)” (《国家重点监控企业自行监测及信息公开办法(试行)》) , the company implemented and completed the self-monitoring program based on its own specific conditions in a timely manner and made the program available to the public after being examined by and filed with relevant competent environmental protection authorities. The analysis methods of the monitoring program comply with the national environmental monitoring technical standards and methods; the monitoring and analysis instruments have been examined and calibrated in strict compliance with the relevant national requirements. Volatile organic matter Jiaozuo Hecheng leakage detection and repair (LDAR) was completed in June 2022. Equipment and facilities such as solvent pipelines and flanges in the workshop were detected, and places with leakage were repaired and rectified. The automated monitoring equipment for sewage has been installed online in accordance with the requirement of environmental assessment technical standards. The online monitoring equipment of COD, ammonia nitrogen, pH, flow and total nitrogen was installed, which has been connected to the national development platform as required. Monthly and quarterly monitoring was carried out strictly in accordance with the requirements of the self-monitoring program, which focused primarily on organized exhaust gas emission, waste water discharge, plant boundary unorganized environmental air and noise. In accordance with the “General Rules for the Self-Monitoring Technical Guidelines for Pollutant Discharge Units” (《排污单位自行监测技术指南总则》) (HJ819-2017) and the relevant requirements (including those on pollution discharge license), the company organized self-monitoring and information disclosure of the pollutants it has discharged, and formulated Shanghai Livzon the Self-monitoring Program. In 2022, the company monitored main exhaust gas outlets once a month, common discharge outlets once half year, noise once every quarter and sewage once a month. The monitoring items and frequency meet the requirements of the pollutant discharge license. Entities with national qualification on inspection were engaged to conduct monitoring strictly in compliance with the relevant national laws and regulations and standards. By considering its own specific conditions, the Company appointed the inspection party to carry out regular Livzon MAB monitoring on sewage and waste gas according to the requirements of the implementation plan of the pollutant discharge permit, each time the monitoring would be conducted strictly in compliance with the relevant national requirements to ensure the accuracy, validity and authenticity of the monitoring data. Entities with national qualification on inspection were engaged to conduct monitoring strictly in compliance with the relevant national laws and regulations and standards. By considering its own specific conditions, the Company appointed the third-party inspection party to carry Sichuan Guangda out regular monitoring on sewage and waste gas according to the requirements of the implementation plan of the pollutant discharge permit. COD water quality online monitoring equipment was installed at the main sewage outlet of the company, which was monitored every 114 Joincare Pharmaceutical Group Annual Report 2022 2 hours, and the data were automatically uploaded to the platform of the government regulatory department. 6. Administrative penalties imposed for environmental issues during the Reporting Period □ Applicable √ N/A 7. Other environmental information to be disclosed □ Applicable √ N/A (II) Statement on environmental protection measures of companies except for key pollutant discharge units √ Applicable □N/A The rest subsidiaries of the Company strictly implemented and obeyed the Environmental Protection Law of the People’s Republic of China, Cleaner Production Law of the People’s Republic of China and other environmental protection and safe production laws and regulations. They constantly increased investment in environmental protection, continuously invested in energy conservation and consumption reduction projects, actively promoted cleaner production, improved comprehensive utilization efficiency of resources, and reduced and avoided pollutants so as to ensure mental and physical health of employees and the coordinated and sustainable development of economic, environmental and social benefits. 1. Administrative penalties imposed for environmental issues □ Applicable √ N/A 2. Refer to other environmental information disclosed by key pollutant discharge units □ Applicable √ N/A 3. Reason for non-disclosure of other relavant environmental information □ Applicable √ N/A (III) Relevant information contributing to ecological protection, pollution prevention and control, and fulfillment of environmental responsibilities √ Applicable □N/A Name of company Relevant information contributing to ecological protection, pollution prevention and or subsidiary control, and fulfillment of environmental responsibilities Jiaozuo Joincare LDAR leak detection and repair was conducted twice in 2022. Creation of environmental safety standardization, management of hazardous waste standardization, onsite inspection, cooperation with the Department of Ecology and Taitai Environment or its entrusted third-party evaluation agency to carry out the safety evaluation and Pharmaceutical inspection of corporate environmental facilities, operating systems and online inspection systems, prompt rectification of hidden hazards proposed were carried out as required by the Municipal Department of Ecology and Environment. The company completed LDAR detection in 2022, to timely repair leakage points and reduce Haibin Pharma unorganized emission of VOCs. Laboratory exhaust gas treatment system was newly built to reduce emission of VOCs. The company completed LDAR detection in 2022, submit environmental protection Xinxiang Haibin commitment to the management department and purchased environmental pollution liability insurance for the company. All waste water from production was collected and sent to the waste water treatment station for Joincare Haibin treatment, and then sent back to the cooling tower for reuse, so as to realize“ zero” discharge of waste water. LDAR leak detection and repair was completed; the amendment and filing of the Environmental Fuzhou Fuxing Emergency Contingency Plan was completed; preparation and inspection of “one policy for one enterprise 2.0” was completed; the preparation of the “Environmental Impact Assessment Report 115 Joincare Pharmaceutical Group Annual Report 2022 on the Phase IV High-end Antibiotics” was in process; in the environmental credit evaluation completed, the company was rated as an environmentally credible enterprise. The monthly and quarterly self-monitoring on waste water, waste gas and noise was completed as required. Self- monitoring of soil and groundwater in 2022 was completed. The construction of 3000m3/d sewage treatment facilities was completed. The installation of waste gas collection and treatment pipeline between the sludge and bacterial residue plate and frame workshop was completed to improve the air quality of the plate and frame workshop. Two rounds of LDAR leak detection and repair was completed as required; unorganized emission of VOCs was reduced; a series of exhaust gas and noise control and improvement measures, such as connecting the exhaust gas fan of Workshop II of Refining I to the exhaust gas treatment equipment, were made to reduce unorganized emission of VOCs; the old biological deodorization tank in the sewage treatment station was replaced, and 2 new exhaust gas spray towers were introduced; exhaust gas collection and treatment in the sewage treatment station was upgraded; pollutants in exhaust gas were degraded efficiently; silencers were installed in the sewage treatment station and on the exhaust gas vent of Fermentation II to reduce air-flow Livzon Xinbeijiang noise; fermentation II and the first floor of power freezer room were enclosed with brick wall to diminish the impact of noise on the surrounding environment; 3 energy-saving silent cooling towers newly purchased were installed on the south side of the freezer to reduce noise generation and effectively use the freezer building to block noise transmission to the community. Other equipment with much noise in the plant was enclosed with sound-absorbing cotton board to reduce noise. The self-monitoring plan of the year was completed and the results of wastewater, exhaust gas and noise met the emission standards. A qualified third party is entrusted to dispose of the waste in compliance with laws and regulations. LDAR leak detection and repair was completed in the year with a reduction of 1.11 tonnes as compared with that befor repair; the equipment for RTO exhaust was maintained regularly to ensure its safe operation and the emission of exhaust gas within the emission standards; items were washed after the completion of RTO process to reduce sulfur dioxide emissions and smell; the trichloromethane liquid nitrogen cryogenic equipment in Workshop 102 was put into use to Livzon Hecheng increase the reuse of trichloromethane to reduce emissions. Qualified units were entrusted to treat hazardous waste with a compliance treatment rate of 100%; and tail gas treatment facilities were added at gas collection station by the QC Testing and Technical Development Department. The self-monitoring program was completed and environmental responsibilities were fulfilled as required. LDAR leak detection and repair was completed; cover and sealing were added to sewage treatment regulating pool; waste gas was collected and treated so as to avoid odor emit; HV frame was replaced in the sewage treatment workshop; water content of sludge was reduced; total volume of sludge was reduced; sludge generated was entrusted to qualified units for treatment; the collection, recovery, treatment of VOCs were completed and online monitoring Gutian Fuxing facilities was installed and put into operation to reduce the random emission of VOCs; and the entrusted testing of waste water, waste gas, soil and groundwater in 2022 was completed, with the results showing they all met standards. the upgrading and reconstruction of boiler tail gas treatment facilities were completed. Hazardous waste was entrusted to qualified companies for compliant treatment to reduce the risk of environmental pollution. Pollutants was discharged according to the standards in the pollution discharge license and the annual self-monitoring of pollution discharge was completed; the measures on energy conservation and emission reduction were formulated according to ESG objectives; solid preparations and steam equipment in high-capacity workshop were renovated; steam usage was Livzon Limin reduced effectively; locations of different drugs in the overhead cabin and TCM cabin were adjusted; storage energy consumption of the two cabins was reduced; three idle water pumps of the factory were used; post-treated waste water was used for watering flowers, trees and grass in the factory in three lines. Installation and debugging of online monitoring equipment were completed; the monthly and quarterly self-monitoring was completed as required; a qualified third party was entrusted to detect waste water and waste gas; compliant treatment of hazardous wastes was made to reduce Livzon the risk of environmental pollution. Environmental impact assessment was conducted for new Pharmaceutical workshops and acceptance of environmental protection project of the newly-built workshop was Factory completed as required. The facilities at the waste water treatment station were renovated to ensure the sewage treatment meets the national standards, and at the same time, improve the treatment efficiency. In 2022, the exhaust sampling port and sampling platform of the hazardous waste storage and waste gas collection and treatment facility was constructed; the fresh air supply facility of the fungus residue crushing room was reconstructed, the original fresh air supply fan installed in Ningxia the middle of the wall was moved to the bottom of the wall, and a new fresh air supply fan was Pharmaceutical installed; the original waste gas treatment facilities of the fermentation workshop of 103-2 were upgraded and improved, and a set of "sodium hypochlorite spray absorption + water spray absorption + dual-phase superoxygen water + micro-nano bubbles" process governance facilities were added; the emergency pool leakage prevention facilities of hazardous chemicals warehouse 116 Joincare Pharmaceutical Group Annual Report 2022 were built; the damaged cover plate of sludge storage tank was replaced;the cover plate of the pre-aeration tank for sewage treatment and the water seal tank of the cover plate of the primary sedimentation tank were repaired and sealed. The original cover plate for the pre-aeration tank was sealed with glass fiber cloth and epoxy resin, and the rusted pipes were painted. The rainwater and sewage collection pipe network facilities with a total length of about 1,000 meters were laid and installed. In December 2022, it was recognized as a city-level green factory in Shizuishan. The monthly and quarterly enterprise self-monitoring work was completed as required. Carried out automation construction; completed the repair and inspection of LDAR; completed the green development evaluation of the pharmaceutical industry in Henan Province; replaced the waste gas treatment part to ensure that the treatment effect of hazardous waste was entrusted to a qualified unit for disposal, and the compliance disposal rate reached 100%; entrusted a qualified third party to detect the waste gas; entrusted a qualified third party to provide operation and maintenance services for wastewater system equipment; completed the implementation of “one policy for one plant” for emergency emission reduction in heavily polluted weather by the Jiaozuo Hecheng Municipal Environmental Protection Bureau; the RTO incinerator equipment operated normally this year, and modified the environmental protection documents such as “Enterprise Environmental Information Disclosure System”, “Pollutant Discharge Permit System and Sewage Treatment Process Operating Procedures”, “Enterprise Environmental Information Disclosure System” 《企业环境信息公开制度》), the “Sewage Discharge Permit System” 《排 污许可证制度》) and the “Sewage Treatment Process Operation Regulations’ (《污水处理工 艺操作规程》). The company has completed the Filing and Registration of the Contingenvy Plan for Emergenty Environmental Incidents; completed the VOCs emission reduction milestone of " one plan for one factory " in accordance with the plan; discharged pollutants in strict accordance with the the Sewage Discharge Permit System obtained, formulated the annual emission self-monitoring programme at the beginning of the year and implemented emission self-monitoring according to the programme, and completed the annual implementation report of the emission permits without Shanghai Livzon any violations of laws or regulations. Meanwhile, we strengthened the daily supervision of the operation of the waste gas treatment facilities and sewage treatment stations, and entrusted a third party to test the emissions of waste gas and sewage every month to ensure the effective operation of the equipment and facilities. The safety facilities, occupational disease protection facilities and pollution prevention facilities of the "Preparation Line 3 and Assembly Line 2 Purification Plant and Utility System" project were designed, constructed and put into production and use at the same time as the workshop renovation project. Entrusted a qualified third party CTI to test the waste water and waste gas according to the requirements of the pollutant discharge license, and entrusted a qualified entity, Dongjiang Environmental-protection Doumen Yongxingsheng Environmental-protection, Co., Ltd. of Dongjiang Environmental Protection (东江环保斗门永兴盛环保公司), to dispose of hazardous wastes in accordance with the regulations, so as to reduce the risk of environmental pollution. Livzon MAB Carried out the environmental impact assessment of the new workshop according to the requirements of "Three Simultaneities" for construction of wotkshops newly built, rebuilt and expanded. The production and R&D sewage was uniformly discharged into the sewage station of Livzon Pharmaceutical Factory in Livzon Industrial Park for treatment and discharge up to the standard. According to the requirements, the company has formulated an annual self-monitoring plan for sewage discharge, entrusted a qualified third party to carry out regular testing of waste water, waste gas and noise at the factory boundary, and the testing results were all qualified; entrusted a qualified unit to carry out compliance disposal of hazardous wastes to reduce the risk of Sichuan Guangda environmental pollution; completed the preparation and filing of the Contingency Plan for Environmental Emergent Incidents of the Company; the environmental protection credit evaluation has been completed, and the preliminary evaluation result was: the entity with good environmental protection credit; the annual implementation report of pollutant discharge permit has been completed. (IV) Measures Taken and Effects on Reducing Carbon Emissions During the Reporting Period Whether to take carbon reduction measures Yes Equivalent of carbon emission reduction (unit: ton) 2,171 Types of carbon emission reduction measures (e.g. Use of "clean energy for power use of clean energy for power generation, use of generation", adopt carbon emission carbon reduction technologies in production, reduction technologies in production" and research and development of new products that other measures, as detailed in "Specific contribute to carbon reduction, etc.) descriptions" below. 117 Joincare Pharmaceutical Group Annual Report 2022 Specific descriptions √ Applicable □N/A Name of company or Measures taken and effects on reducing carbon emissions during the Reporting Period subsidiary 1. by upgrading the preheater of the No. 1 rectification tower in the solvent storage, saved about 2,000 tons of steam and reducing about 600 tons of carbon emissions annually; 2. by changing the structure of isopropyl alcohol distillation tower and the number of distillation, Jiaozuo Joincare saved about 100 tons of steam annually, reduce carbon emissions about 30 tons; 3. by upgrading and replacing an air suspension aeration fan, saved 120,000 kWh of electricity and reduce carbon emissions by about 60 tons per year. 1. in response to the call of the municipal government, the lighting in the park was replaced with energy-saving lamps, obtaining remarkable power-saving effect; 2. in accordance with the energy-saving requirements of the municipal government, we Taitai Pharmaceutical organized to replace the high-power motor in the factory with a high-efficiency energy-saving motor and installed a frequency conversion device to maximize energy saving; 3. upgraded 4T boilers with low nitrogen burners; 4. chose public transport for daily traffic, low-carbon travel, and turned off lights and machines. Carried out carbon verification and energy saving diagnosis, sorted out key energy-use Haibin Pharma equipment, and implemented targeted energy saving transformation to reduce carbon emissions. 1. by using diaphragm pump to replace centrifugal pump, saved 27,000 kWh of electricity per year, reduced carbon emissions about 14 tons; 2. adding preheater for solvent recovery and using steam condensate to preheat mother liquor raw materials can save about 3,600 tons of steam and reduce carbon emissions about 1,080 tons Xinxiang Haibin per year; 3. the existing chemical pump was replaced by high efficiency and energy saving pump in the circulating water system, which is expected to save 774,000 kWh of electricity and reduce carbon emissions of about 387 tons per year; 4. chose public transport for daily traffic and low-carbon travel. Purchased new standard energy-saving equipment, developed the habit and thinking of saving electricity, saved natural gas and carried out multiple maintenance in daily use of boiler, and Joincare Haibin frequemt;y inspected pipelines, took good insulation measures, and used pure electric cars to save fuel when going out. Adopted solar water heater in the dormitory. Used photovoltaic power generation to reduce power consumption; renovated high- energyconsuming pumps for energy conservation to effectively reduce energy consumption; replaced with high-efficiency motor water pumps to save energy consumption; vigorously Fuzhou Fuxing promoted energy conservation and consumption reduction, and called on employees to realize the concept of “turning off lights, air conditioners and computers before leaving office” during their daily work. Introduced photovoltaic power generation to reduce power consumption; used water kinetic energy instead of electric motors to drive the cooling tower fans to reduce the electric energy consumption while ensuring the cooling effect; pre-heated the soft water of the boiler by the heat generated from the operation of the air compressor to raise the temperature of the inlet water of the boiler and effectively reduce the consumption of natural gas; regularly cleaned the inner wall Livzon Xinbeijiang of the MVR equipment to increase the evaporation rate of sugar water of the MVR equipment by about 40%, hence effectively reducing the running time of the MVR equipment and greatly reducing electricity onsumption; replaced old boilers of high energy consumption and high maintenance cost with new boilers. Accordingly, the average natural gas consumption reduced by 1.06 m3 per tonne of steam generated. Maintained and updated chiller units to make more rational use of energy and saved electricity consumption for production through more reasonable production scheduling by the production department; used natural gas as fuel for canteens and boilers; replaced sewage treatment Roots blowers in the environmental protection center with magnetic levitation blowers with an energy Livzon Hecheng saving rate of about 30%, saving about 107,000 kWh of electricity consumption per year; called on all employees of the factory to respond to electricity conservation, turn off lights and air conditioners before leaving office, and limited the minimum temperature of air conditioners; promoted green travel, encouraged the use of public transportation when going out to work, and set up shuttle buses to transport employees to and from work. Installed 4 air compressors with a capacity of 130m3/min to replace the original air compressor with high power consumption to reduce power consumption; replaced one chiller unit to reduce Gutian Fuxing electricity consumption; called on all employees to “save every drop of water, save every kilowatt of electricity”, so that the lights are turned off and the equipment is powered off before leaving office. Appropriately adjusted the temperature and humidity settings of the air conditioning system Livzon Limin (within the standard range) in the solid workshop to keep it as close to the outside temperature 118 Joincare Pharmaceutical Group Annual Report 2022 and humidity as possible, thus reducing steam consumption; reduced energy consumption by controlling the number of running compressors in the air conditioning units and setting parameters by the Quality Control Department, and by implementing intermittent use mode for the bioassay lab; used hot tailwater from the water distiller in the production workshop to heat the boiler soft water, thus reducing the consumption of natural gas; renovated the air conditioning ventilation system at the R&D Centre to save electricity. Reduced electricity consumption by replacing incandescent lamps with LED lamps; refurbished photovoltaic inverter cabinets and roof-mounted photovoltaic modules, improving the photovoltaic power generation efficiency after refurbishment, saving about 600,000 kWh of Livzon electricity per year; introduced purchased steam to reduce boiler combustion and save energy; Pharmaceutical further strengthened the energy conservation management of functional departments, turned off Factory lights during the lunch break, encouraged employees to turn off lights and computers to save electricity before leaving seats or office; set up shuttle buses to transport employees to and from work. Renovated the phenylalanine concentration system and adopted MVR concentration to replace the original triple-effect concentration system, thus reducing energy consumption by about 50%. Ningxia Regularly overhauled and maintained the boiler system to ensure the efficient operation of the Pharmaceutical boiler body and the desulfurization and dust removal facilities. Increased the consumption of steam from external supply to cut the use of coal and reduce carbon emissions. Collected and reused steam condense to reduce steam consumption, so as to reduce carbon emissions; changed the packaging equipment to automatic packaging to improve production efficiency; vigorously promoted energy saving and consumption reduction internally, called on all employees to “save every drop of water, save every kilowatt of electricity”, and uniformly managed the paint in the workshop to eliminate waste; installed additional mirrors behind the Jiaozuo Hecheng steam pipeline drainage valves to observe whether there is steam loss; led the steam condense to the production auxiliary system of the hot water tank and the crystallization tank to reduce the use of steam; changed the lighting in the common areas of the workshop, corridors, etc. to sound- or light-controlled switches and gradually replaced the workshop lighting with LED lights; gradually replaced high energy consuming equipment and facilities in workshops with low energy consuming or automated interlocking devices. Further strengthened the daily energy-saving management according to the established energy- saving plan, effectively improved the energy-saving awareness of employees through inspection, publicity and other means, and cultivated good habit of saving water and electricity among employees; optimized the peptide splicing process, increased the peptide splicing yield by more Shanghai Livzon than 10%, thus reducing the power consumption per unit of product; transformed the solid preparation workshop into the powder injection workshop which produces less waste and conserves electricity; while comfortable air conditioning unit (cooling) utilized the chilled water unit in the power room, the multi-expansion air conditioning unit was placed outdoors to use air cooling, saving cooling capacity and reducing energy consumption. Introduced purchased steam to save energy. Effectively improved the energy-saving awareness of employees through inspection, publicity and other means, and cultivated good habit of saving Livzon MAB water and electricity among employees; used LED lights to reduce electricity consumption, and encouraged employees to turn off lights and computers to save electricity before leaving office. Set up shuttle buses to transport employees to and from work. Clean energy was used, energy use efficiency was improved and outdated equipment was eliminated. For example, Class 1 energy-efficient motors and related power products was used Sichuan Guangda for all new plant construction, and the highly efficient, energy-saving and low-cost MVR concentration technology was used for concentration equipment. In addition, the energy-saving awareness among staff is effectively raised by strengthening daily management. II.Work on Corporate Social Responsibility (I) Whether to disclose separate corporate social responsibility report, sustainable development report or ESG report √Applicable □N/A The Company has separately disclosed its corporate social responsibility report. For details, please refer to the 2022 Corporate Social Responsibility Report of Joincare Pharmaceutical Industry Group Co., Ltd. disclosed by the Company on the website of Shanghai Stock Exchange (www.sse.com.cn) on 11 April 2023 for details. (II)Specific situation of work on corporate social responsibilities √Applicable □N/A 119 Joincare Pharmaceutical Group Annual Report 2022 External donation, public Quantity/content Description welfare Mainly include investment in public welfare projects for chronic diseases, industrial Total investment (RMB’0,000) 1,211.7 assistance, community health, and nature conservation. Mainly include investment in nature Including: Funds (RMB’0,000) 569.9 conservation project. Cash converted from materials Mainly include investment in public welfare 641.8 (RMB’0,000) projects for chronic diseases. Mainly include projects of low-income Number of beneficiary (person) 1,485 chronic disease patients and industrial revitalization. Specific description √Applicable □N/A The Company is striving to be an explorer in the healthcare industry and insisting on creating a healthy life driven by technology. The Group pays great attention to its sustainable development, and actively focuses on the internal regulatory environment and external policy guidance. Considering China's 14th Five-Year Plan and the local government's development plan, the Group has formulated a CSR strategy and goals adapting to its current business situation. Focusing on“ health”, the Group's CSR strategy aims to provide the whole society with high-quality, safe, accessible and affordable medical products and services through the development of its principal businesses, while improving the overall strength of the health industry. Meanwhile, the strategy is committed to empowering employees and communities, emphasizing environmental protection and promoting the overall health development in society. The development of enterprises relies on society. Over the years, the Company has conscientiously fulfilled its social responsibility, paid taxes according to law, supported social public welfare projects, and actively assumed its social responsibility for building a harmonious society. At the same time, the Group was actively creating social value. It generated tax revenues for the government of RMB1,668 million, paid RMB2,261million in salary to employees, distributed dividends and paid interest worth RMB1,351 million to banks and other creditors, donated funds and goods totaling RMB12.217 million to the society, and achieved a social contribution per share of approximately RMB3.52 for the society in 2022. For our performance of social responsibility, see the 2022 Corporate Social Responsibility Report of Joincare Pharmaceutical Industry Group Co., Ltd. disclosed by the Company on the website of Shanghai Stock Exchange (www.sse.com.cn) on 11 April 2023 for details. III.Consolidation and expansion of achievements in poverty alleviation and rural revitalization Targeted Poverty Alleviation and Rural Quantity/content Description Revitalization Project Public welfare projects for chronic Total investment (RMB’0,000) 300 diseases to help rural revitalization Including: Funds (RMB’0,000) Cash converted from materials (RMB’0,000) 300 Donation of drugs for chronic diseases Low-income patients with chronic Number of beneficiary (person) 1,400 diseases Forms of assistance (such as industrial Poverty alleviation poverty alleviation, vocational poverty through industrial alleviation, educational poverty alleviation, development etc. ) 120 Joincare Pharmaceutical Group Annual Report 2022 Specific description √Applicable □N/A 1. Industrial revitalization The Company follows important guiding principles of the CPC Central Committee and the General Secretary. In accordance with the relevant requirements, we establish and implement the plan of “Revitalization of Astragalus Root (黄芪) Industry” and adopt the model of “Company + Base” and “Company + Professional Cooperative”, encouraging locals to cultivate and process astragalus root and develop the astragalus root industry based on the local conditions. Making it a pillar industry for local economy in the long-term and a new path to improve the lives of the people, the Company explores the development of the featured astragalus root industry to promote the construction of the “Chinese Medicine Ecological Base”. The “Revitalization of Astragalus Root Industry” program was initiated in 2017 and is still in operation today. Datong Livzon Qiyuan Medicine Co., Ltd. (大同丽珠芪源药材有限公司 ) (“Datong Livzon”), a subsidiary of the Company’s controlled subsidiary Livzon Group, built cultivation bases independently in Hunyuan County of Datong City in Shanxi Province and Zizhou County of Yulin City in Shaanxi Province. And Datong Livzon cooperated with 12 cooperatives and 3 individuals to jointly build cultivation bases for astragalus root in Tianzhen County of Datong City and Ying County of Shuozhou City in Shanxi Province and Yulin City of Shaanxi Province. The total area of the self-built bases and jointly constructed bases is about 33,000 mu and a total of 265 people have been assisted. This program has effectively boosted the economy of corresponding areas in Shanxi and Shaanxi. During the Reporting Period, the planting area of the self-built base in Hunyuan County of Datong City in Shanxi Province increased by 300 mu, and the number of newly hired local workers reached 55. In addition, in line with the country's "rural revitalization strategy," Datong Livzon cooperated with the village committee of Mazhuang Village, Guaner Township, Hunyuan County, Datong City, Shanxi Province to initiate the “Joint Construction by Villages and Enterprises” program to construct the initial processing plant for cultivation bases for astragalus root, which has been completed and put into use. In addition, the Company provided training on the new version of "Good Agricultural Practice of Medicinal Plants and Animals" for management staff of joint construction bases and about 30 growers in Zizhou County, Yulin District, Shaanxi Province, and provided technical guidance and practical training on the traceability system of Chinese medicinal materials. At the same time, meteorological observation stations were set up in the joint-built base in Tianzhen County of Datong City, Shanxi Province and the joint-built base in Zizhou County of Yulin City, Shaanxi Province, and environmental inspection was carried out for all the joint-built bases, providing data support for their field operations. This year, Shanxi and Shaanxi joint-built bases employed 85 local workers, harvesting a total of 184.50 tons of fresh astragalus root. 2. Access to public welfare for rural revitalization chronic diseases prevention and treatment In supporting consolidation and expansion of achievements in poverty alleviation and rural revitalization and In order to respond positively to the call of national policy, Joincare have launched “Access to Public Welfare for Chronic Diseases Prevention and Treatment (普惠慢病防治公益项 目)” program by combining our own industrial advantages. The program targets at common chronic diseases such as hypertension, hyperlipidemia, cardiovascular and cerebrovascular diseases, and treatment drugs have been donated to remote areas, including Pravastatin Capsules (普伐他汀钠胶 囊), Amlodipine Besylate Capsules (苯磺酸氨氯地平胶囊), Valsartan Capsules (缬沙坦胶囊), and Isosorbide Bononitrate Tablets ( 单硝酸异山梨酯片), which could be worth millions of RMB. These drugs can really help families in remote areas, make it convenient for patients in the regions 121 Joincare Pharmaceutical Group Annual Report 2022 to take drugs nearby, help the families with patients to alleviate medical pressures, and provide timely assistance. Based on actual conditions, the project regularly makes continuous drug donations to remote areas and helps the families with patients in such regions. The project also helps to promote local development of rural revitalization and contributes to the state strategic goal of common prosperity. Since late 2018 onwards, with the support of local government agencies and relevant authorities at all levels, we carried out the “Inclusive Chronic Disease Prevention and Control Public Welfare Project” successively in areas including Chaotian District of Guangyuan City, Songpan County, Jiange County and Pingwu County of the Autonomous Prefecture of Aba Zangs and Qiangs in Sichuan Province, Hunyuan County, Guangling County and Lingqiu County of Datong City in Shanxi Province, Dongxiang County, Tianzhu County, Linze County and Shandan County in Gansu Province, Xianghai national nature reserve in Jilin Province, Chayu County in Tibet Autonomous Region, Macun District of Jiaozuo City in Henan Province, Huangshan District of Huangshan City in Anhui Province, Suining County of Hunan Province, and Fenyi County of Jiangxi Province, bringing benefits to many patients. Joincare won the awards of “19th Shenzhen Care Action Top 100 Projects of Residents Satisfaction (第十九届深圳关爱行动百佳市民满意项目)” and “Pioneering Enterprise Award in Social Responsibility (社会责任先锋企业奖)” for its excellent projects supporting urban revitalization. As at 31 December 2022, the project covered 8 provinces and one autonomous region, among which 17 were remote areas in need of help and one was natural reserve at state level, which helped more than 6,400 low-income patients. In 2023, it is expected to donate drugs to areas including Hubei, Gansu, Anhui and Sichuan. 122 Joincare Pharmaceutical Group Annual Report 2022 Chapter 6 Major Events I. Fulfillment of undertakings (I) Undertakings fulfilled during the Reporting Period or not yet fulfilled as of the Reporting Period by the parties to the commitment such as de facto controllers, shareholders, related parties, acquirers of the Company and the Company √Applicable □N/A Specific Next plan Whether Whether reasons for should be Time and time there is a Commitment Commitment Commitment commitment is failure in stated in case of Subject limit of time limit background type content strictly fulfilled timely failure in commitment for in time fulfillment timely fulfillment shall be given fulfillment Shenzhen Baiyeyuan Investment Co., Ltd., the controlling shareholder of the Company, undertook that it would not be directly or indirectly engaged in or cause subsidiaries and branches under its control to be engaged in any business Settlement of or activity constituting horizontal competition with the Company after the 30 April 2001, horizontal Baiyeyuan founding of the Company, including but not limited to the research, production No Yes - - long-term competition and sales of any products that were the same as or similar to products under research, production and sales of the Company, and was willing to undertake compensation responsibility for economic losses to the Company arising from violation of the said commitment. Whereas the domestically listed foreign shares of Livzon Group, a controlled subsidiary of the Company, sought listing on the Main Board of the Stock Exchange of Hong Kong Limited, in order to fully ensure smooth completion of the said event and in compliance with relevant requirements of the Stock Exchange of Hong Kong Limited, the controlling shareholders, de facto Commitment controller of the Company and the Company entered into relevant undertakings related to initial with Livzon Group as follows: 1. The controlling shareholders, de facto public offering controller and persons acting-in-concert of the Company, the Company and its controlled subsidiaries except for Livzon Group did not or would not be, Baiyeyuan, de directly or indirectly, engaged in any business that constituted competitive Settlement of facto controllers 10 January relation or potential competitive relation with drug research, development, horizon and persons 2014, long- No Yes - - production and sale businesses (“Restricted Businesses”) of Livzon Group competition acting-in concert, term from time to time. For the avoidance of doubt, the scope of Restricted and the Company Businesses did not cover products that were researched, developed, manufactured and sold on the date of relevant letter of undertaking by the controlling shareholders and de facto controller of the Company, the Company and its controlled subsidiaries except for Livzon Group; 2. If any new business opportunity was found to constitute competitive relation with Restricted Businesses, the controlling shareholders, de facto controllers and persons acting-in-concert of the Company, the Company and its controlling subsidiaries except for Livzon Group would inform Livzon Group in written form immediately and firstly provide Livzon Group with the business opportunity in 123 Joincare Pharmaceutical Group Annual Report 2022 accordance with reasonable and fair terms and conditions. If Livzon Group gave up the business opportunity, the controlling shareholders and de facto controllers of the Company, the Company and its controlled subsidiaries except for Livzon Group may accept the business opportunity in accordance with the terms and conditions that were not superior to those offered to Livzon Group; 3. If assets and businesses that directly or indirectly constituted competitive relation and potential competitive relation with Restricted Businesses were intended to be transferred, sold, leased, licensed to use or otherwise transferred or allowed to use (these Sales and Transfers), the controlling shareholders and de facto controllers of the Company, the Company and its controlled subsidiaries except for Livzon Group would provide the right of first refusal for Livzon Group under the same condition. If Livzon Group gave up the right of first refusal, the controlling shareholders, de facto controllers and persons acting-in-concert of the Company, the Company and its controlled subsidiaries except for Livzon Group would carry out these Sales and Transfers to a third party in accordance with main terms that were not superior to those offered to Livzon Group; 4. The controlling shareholders, de facto controllers and persons acting-in-concert of the Company, the Company and its controlled subsidiaries except for Livzon Group would not be engaged in or involved in any business that might damage the interests of Livzon Group and other shareholders through the relation with shareholders of Livzon Group or the identity of shareholders of Livzon Group; 5. The controlling shareholders, de facto controllers and persons acting-in-concert of the Company, the Company and its controlled subsidiaries except for Livzon Group would not or cause its contact persons (except for Livzon Group) to directly or indirectly: (1) induce or attempt to induce any director, senior management or consultant of any member of Livzon Group to terminate his/her employment with or to be an employee or consultant of Livzon Group at any time (whichever is applicable), no matter if relevant acts of the person were against the Employment Contract or Consultancy Agreement (if applicable); (2) Within three years after any person terminated to be the director, senior management or consultant of any member of Livzon Group, employ the person who had or might have any confidentiality information or business secret in relation to Restricted Businesses (except for the director, senior management or consultant of the Company and/or its controlling subsidiaries except for Livzon Group on the date of issuance of relevant letter of undertaking); (3) Recruit or lobby any person carrying out business in any member of Livzon Group, accept orders, or carry out business separately, through any other person or as any person, firm, or manager, advisor, consultant, employee, agent or shareholder of any company (competitor of any member of Livzon Group), or lobby or persuade the person making transaction with Livzon Group or negotiating with Livzon Group on Restricted Businesses to terminate its transaction with Livzon Group or reduce its normal business volume with Livzon Group, or ask for more favorable transaction terms to any member of Livzon Group. 6. The controlling shareholders, de facto controllers and persons acting-in-concert of the Company, the Company and its controlled subsidiaries except for Livzon Group further undertook that: (1) They would allow and cause relevant contact persons (except for Livzon Group) to allow independent directors of Livzon Group to review if the Company and its controlled subsidiaries except for Livzon Group obeyed the Letter of Undertaking at least once a year; (2) They would provide all the data required for annual review and implementation of the Letter of 124 Joincare Pharmaceutical Group Annual Report 2022 Undertaking for independent directors of Livzon Group; (3) They would allow Livzon Group to disclose the decision on whether the controlling shareholders and de facto controllers of the Company, the Company and its controlled subsidiaries except for Livzon Group obeyed and implemented the Letter of Undertaking reviewed by independent directors of Livzon Group through the annual report or announcement; (4) The controlling shareholders, de facto controllers and persons acting-in-concert of the Company, the Company (and its controlled subsidiaries except for Livzon Group) would provide Livzon Group with the Letter of Confirmation in relation to compliance with clauses of the Letter of Undertaking every year so as to be included in the annual report of Livzon Group. 7. The controlling shareholders, de facto controllers and persons acting-in-concert of the Company, and the Company undertake that they would bear corresponding legal responsibility and consequence arising from violation of any clause relevant letter of undertaking from the date of issuance thereof by the Company (or the Company's controlled subsidiaries except for Livzon Group or its contact persons). 8. The said undertakings would terminate in case of the following circumstances (whichever is earlier): (1) The controlling shareholders, de facto controllers and persons acting-in-concert of the Company, the Company and any of its controlled subsidiaries were not the controlling shareholders of Livzon Group anymore; (2) Livzon Group terminated the listing of its shares on the Hong Kong Stock Exchange and other overseas stock exchanges (except that shares of Livzon Group stopped to be traded temporarily for any reason). From 8 March 2016 to the date of completion of The Company remedial Do not interfere in the operation and management activities of Livzon Group Others and de facto measures in Yes Yes - - or encroach on the interests of Livzon Group controllers connection with the non- public offering of Livzon Group Pursuant to the Guiding Opinions on Matters Relating to the Dilution of Current Commitment Returns As a Result of Initial Public Offering, Refinancing and Major Asset related to seasoned Restructuring (Announcement of CSRC [2015] No. 31), the company shall offerings undertake to adopt specific remedial measures relating to dilution of current From 11 May returns as a result of the company's initial public offering, refinancing of the 2017 to the listed company, or major asset restructuring and shall fulfill such undertaking. date of Pursuant to relevant provisions of CSRC, Zhu Baoguo, the de facto controller completion of Baiyeyuan and of Shenzhen Baiyeyuan Investment Co., Ltd., a controlling shareholder:1. Do remedial Others the de facto Yes Yes - - not intervene in the operation and management activities or encroach on the measures in controller interests of the company; 2. If CSRC issued other new regulatory provisions on connection the remedial measures in relation to returns and the relevant undertakings and with rights the aforesaid undertakings did not conform to such provisions from the date of issue of issuance of the undertaking to the completion of IPO share allotment, the Joincare Company/the de facto controller would undertake to issue a supplemental undertaking in accordance with the latest provisions of CSRC; 3. The Company/the de facto controller undertook to practically take the remedial 125 Joincare Pharmaceutical Group Annual Report 2022 measures in relation to returns formulated by the company and fulfill the undertaking concerning the remedial measures. In case of violation of the undertaking, causing losses to the company or investors, the Company/the de facto controller was willing to assume compensation responsibilities to the company or investors in accordance with law. In case of violation of the said undertakings or rejection to fulfill the said undertakings, as one of the liability subjects relating to the remedial measures concerning returns, it was agreed that relevant punishment shall be imposed on or relevant management measures shall be taken against the Company/the de facto controller by CSRC, the Shanghai Stock Exchange and other securities regulators in accordance with relevant provisions and rules set or issued by them. After the proceeds for issuance of allotment were in place, the Company would use them according to the disclosure in the announcement, and carry out the From the date policies, including deposit in special account, approval by specially-assigned of proceeds person, and special use of special funds in accordance with management for issuance of measures for proceeds of the Company. The Board of the Company would the Rights Others The Company regularly check the progress of projects invested with proceeds, issue a special issue in place No Yes - - report on deposit and use of proceeds, engage an accounting firm during the to the date of annual audit to issue an verification report on deposit and use of proceeds, completion of would be supervised by regulators and sponsors at any time, and would not use of make major investment, asset purchase or similar financial investment though proceeds proceeds in disguise. 1. While transferring tradable shares subject to selling restrictions held by the company in Livzon Group, the company shall strict obey relevant provisions of Other commitments Guidelines of Listed Companies on Transfer of Stock Shares Subject to made to the Selling Restrictions ([2008] No. 15); 2. If the Company had shares subject to 17 December medium and small Others The Company selling restrictions held by it in Livzon Group that were planned to be sold 2008, long- No Yes - - shareholders of the through the bid trading system of Shenzhen Stock Exchange and reduced more term company than 5% shares within six months from the first share reduction, the Company would pass the Announcement on Sales disclosed by Livzon Group within two trading days before the first share reduction. 126 Joincare Pharmaceutical Group Annual Report 2022 (II) If the Company has made profit forecast on its assets or projects and the Reporting Period is still within the profit forecast period, the Company shall give an explanation on why its assets or projects achieved its profit forecast □Realized □Unrealized √N/A (III) Fulfillment of performance covenant and its influence on goodwill impairment test □Applicable √N/A II. Information on Non-operating use of funds by controlling shareholders and other related parties during the Reporting Period □Applicable √N/A III. Information on illegal guarantees □Applicable √N/A IV. The Board's statement on the “non-standard opinion auditor's report” issued by the appointed accounting firm □Applicable √N/A V. Analysis and explanation from the Company on the reasons and impact of the change of accounting policies, accounting estimates or correction on material accounting errors (I) Analysis and explanation from the Company on the reasons and impact of the change of accounting policies or accounting estimates □Applicable √N/A (II) Analysis and explanation from the Company on the reasons and impact of the correction on material accounting errors □Applicable √N/A (III) Communication with former appointed accounting firm □Applicable √N/A (IV) Others □Applicable √N/A 127 Joincare Pharmaceutical Group Annual Report 2022 VI. Appointment and termination of appointment of accounting firm Unit: 10,000 Yuan Currency: RMB Current accounting firm Name of domestic accounting firm Grant Thornton (Special General Partnership) Remuneration for domestic accounting firm 128 Continuous years of auditing services provided by domestic 4 accounting firm Name of certified public accountant (“CPA”) of domestic Wang Yuan(王远) and Wang Qilai(王其来) accounting firm Continuous years of CPA audit services of domestic accounting 1 and 4 firms Name Fee Accounting firm for internal control audit Grant Thornton (Special General Partnership) 32 Statement on appointment and termination of appointment of accounting firm □Applicable √N/A Statement on re-engagement of accounting firm during the audit period □Applicable √N/A VII. Risk of delisting (1) Reasons for delisting risk warning □Applicable √N/A (2) Countermeasures to be taken by the Company □Applicable √N/A (3) Risk of delisting and the reasons □Applicable √N/A VIII. Matters related to bankruptcy and reorganization □Applicable √N/A IX. Material litigation and arbitration □The Company was involved in material litigation or arbitration in current year √The Company was not involved in material litigation or arbitration in current year 128 Joincare Pharmaceutical Group Annual Report 2022 X. Violations committed by the listed company and its directors, supervisors, senior management, controlling shareholders and de facto controllers, punishments imposed and rectifications □Applicable √N/A XI. Credit standing of the Company and its controlling shareholders and de facto controllers during the Reporting Period □Applicable √N/A XII. Material related-party transactions (I) Related-party transactions in connection with day-to-day operation 1. Matters already disclosed in interim announcements about which no new information is available √Applicable □N/A Overview Query index Pursuant to the “Resolution on Connected Transactions in the See the “Announcement on Resolutions Ordinary Course of Business of the Majority-owned Subsidiaries Considered and Approved at the 9th Meeting of of Jiaozuo Joincare and Jinguan Electric Power” considered and the 8th Session of the Board of Joincare approved at the 9th Meeting of the 8th Session of the Board on 29 Pharmaceutical Group Industry Co., Ltd.” (Lin March 2022, Jiaozuo Joincare intended to purchase no more than 2022-026) and the “Announcement of Joincare RMB270 million (inclusive) of steam and power from Jinguan Pharmaceutical Group Industry Co., Ltd. on the Electric Power in 2022 so as to satisfy the demands of Jiaozuo Connected Transactions in the Ordinary Course of Joincare for steam and power in the process of production and Business of the Majority-owned Subsidiaries of operation. The independent directors of the Company gave prior Jiaozuo Joincare and Jinguan Electric Power” (Lin approval opinions on the Resolution and gave opinions on the 2022-032) disclosed by the Company on 31 March approval of the independent directors at the Board meeting. 2022 for details. The “Resolution on the Adjustment of Connected Transactions in the Ordinary Course of Business of the Majority-owned Subsidiary Jiaozuo Joincare and Jinguan Electric Power” was considered and approved at the 20th Meeting of the 8th Session of the Board on 12 December 2022: given that the actual power See the “Announcement on Resolutions consumption of Jiaozuo Joincare was higher than forecast at the Considered and Approved at the 20th Meeting of beginning of the year, the annual transaction amount estimated at the 8th Session of the Board of Joincare the beginning of the year between Jiaozuo Joincare and Jinguan Pharmaceutical Group Industry Co., Ltd.” (Lin Electric Power is not sufficient to cover Jiaozuo Joincare's actual 2022-141) and the “Announcement of Joincare production requirements in 2022, to satisfy the demands of Jiaozuo Pharmaceutical Group Industry Co., Ltd. on the Joincare for steam and power in the process of production and Adjustment of Connected Transactions in the operation, purchase from Jinguan Electric Power, was changed Ordinary Course of Business of the Majority- from RMB270 million (inclusive) to RMB280 million (inclusive) owned Subsidiaries of Jiaozuo Joincare and in 2022. The independent directors of the Company gave prior Jinguan Electric Power” (Lin 2022-143) disclosed approval opinions on the Resolution and gave opinions on the by the Company on 13 December 2022 for details. approval at the Board meeting.Both parties referred to the market price to fix a price of the said connected transactions. During the Reporting Period, the actual amount of the said connected transactions was RMB268.6670 million. 2. Matters already disclosed in interim announcements about which new information is available □Applicable √N/A 129 Joincare Pharmaceutical Group Annual Report 2022 3. Matters not disclosed in interim announcements □Applicable √N/A (II) Related-party transactions involving acquisition or sale of assets or equity 1. Matters already disclosed in interim announcements about which no new information is available □Applicable √N/A 2. Matters already disclosed in interim announcements about which new information is available □Applicable √N/A 3. Matters not disclosed in interim announcements □Applicable √N/A 4. Fulfillment of performance covenants (if any) during the Reporting Period □Applicable √N/A (III) Material related-party transactions involving joint external investment 1. Matters already disclosed in interim announcements about which no new information is available □Applicable √N/A 2. Matters already disclosed in interim announcements about which new information is available □Applicable √N/A 3. Matters not disclosed in interim announcements □Applicable √N/A (IV) Claims and debts with related parties 1. Matters already disclosed in interim announcements about which no new information is available □Applicable √N/A 2. Matters already disclosed in interim announcements about which new information is available □Applicable √N/A 3. Matters not disclosed in interim announcements √Applicable □N/A Unit: Yuan Currency: RMB Offer funds to related parties Receive funds from related parties Related party Relationship Amount Amount Opening Closing Opening Closing incurred in the incurred in the balance balance balance balance current period current period Guangdong Blue Treasure Pharmaceutical Co., Ltd.* Others 25,653,956.55 -16,371,152.26 9,282,804.29 379,960.00 -379,960.00 0.00 (广东蓝宝制药有限公司) 130 Joincare Pharmaceutical Group Annual Report 2022 Zhuhai Sanmed Gene Diagnostics Ltd.* (珠海市圣 Others 229,288.83 -127,761.85 101,526.98 美基因检测科技有限公司) Subsidiaries of Sichuan Healthy Deer Hospital Management Co., Ltd. (四川 Others 337,395.02 160,433.28 497,828.30 8,936.17 12,011.72 20,947.89 健康阿鹿医院管理有限公司 之子公司) Zhuhai Sanmed Biotech Inc.* (珠海圣美生物诊断技术有 Others 211,200.00 0.00 211,200.00 限公司) Shenzhen Youbao Technology Co., Ltd. (深圳 Others 154,500.00 33,600.00 188,100.00 市有宝科技有限公司) Zhongshan Renhe Health Product Co., Ltd. (中山市仁 Others 469,895.78 0.00 469,895.78 和保健品有限公司) Shenzhen Jiekang Health Care Co., Ltd.* (深圳市捷康 Others 18,577,246.63 -18,577,246.63 0.00 保健有限公司) Shenzhen Health Deer Technology Co., Ltd.(深圳 Others 4,680.00 0.00 4,680.00 市健康阿鹿信息科技有限公 司) Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. * Associated 8,240,517.56 67,484,396.01 75,724,913.57 (焦作金冠嘉华电力有限公 company 司) Total 53,878,680.37 32,602,268.55 86,480,948.92 388,896.17 -367,948.28 20,947.89 During the Reporting Period, the Company had normal operating fund transactions with connected Cause for claims and debts with related parties parties. Impact of claims and debts with related parties The said credits and debts with connected persons are operating fund transactions; there was no non- on the Company operating use of funds of the Company by shareholders and connected part. (V) Financial business among the Company, related financial companies, financial companies controlled by the Company, and related parties □Applicable √N/A (VI) Others □Applicable √N/A XIII. Material contracts and their fulfilments (I) Trusteeship, contracting and lease 1. Trusteeship □Applicable √N/A 2. Contracting □Applicable √N/A 131 Joincare Pharmaceutical Group Annual Report 2022 3. Lease □Applicable √N/A (II) Guarantees √Applicable □N/A Unit: 10,000 Yuan Currency: RMB Date of Relation-ship guarantee Whether Guaranteed between the Guaranteed Guaranteed (signing Effective Expiration Guarantee Fulfilled Overdue Overdue there's a for a Guarantor guarantor and Relationship party amount date of date date type or not or not amount counter- related the listed agreement guarantee party or not company ) Headquarter Jinguan Joint Joincare of the Electric 3,840.00 2022/2/14 2022/2/14 2022/11/30 liability Yes No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 4,960.00 2022/2/24 2022/2/24 2022/12/26 liability Yes No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 3,000.00 2022/6/8 2022/6/8 2023/6/8 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 3,000.00 2022/6/22 2022/6/22 2023/6/23 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 4,000.00 2022/7/11 2022/7/11 2023/7/11 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 3,000.00 2022/7/11 2022/7/11 2023/7/11 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 2,000.00 2022/7/15 2022/7/15 2023/7/15 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 3,000.00 2022/8/8 2022/8/8 2023/8/8 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 3,200.00 2022/9/16 2022/9/16 2023/9/16 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 3,800.00 2022/10/9 2022/10/9 2023/10/9 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 3,200.00 2022/10/12 2022/10/12 2023/10/12 liability No No 0 Yes Yes Assoiate Company Power guarantee 132 Joincare Pharmaceutical Group Annual Report 2022 Headquarter Jinguan Joint Joincare of the Electric 3,000.00 2022/11/24 2022/11/24 2023/11/24 liability No No 0 Yes Yes Assoiate Company Power guarantee Headquarter Jinguan Joint Joincare of the Electric 4,640.00 2022/12/19 2022/12/19 2023/12/19 liability No No 0 Yes Yes Assoiate Company Power guarantee Wholly- Jinguan Joint Jiaozuo owned Electric 2,000.00 2022/3/28 2022/3/28 2022/12/13 liability Yes No 0 Yes Yes Assoiate Joincare subsidiary Power guarantee Wholly- Jinguan Joint Jiaozuo owned Electric 2,000.00 2022/12/14 2022/12/14 2023/12/14 liability No No 0 Yes Yes Assoiate Joincare subsidiary Power guarantee Total guaranteed amount occurred during the Reporting Period 48,640.00 (excluding guarantees to subsidiaries) Total guaranteed amount as of the End of the Reporting Period (A) 37,840.00 (excluding guarantees to subsidiaries) Guarantee provided by the Company and its subsidiaries to subsidiaries Total amount of guarantees to subsidiaries during the Reporting Period 346,492.65 Total amount of guarantees to subsidiaries as of the End of the Reporting 250,888.69 Period (B) Total guaranteed amount of the Company (including guarantees to subsidiaries) Total guaranteed amount (A+B) 288,728.69 Percentage of total guaranteed amount in the Company's net assets (%) 13.11 In which: Amount of guarantees provided to shareholders, de facto controllers and 0.00 their related parties (C) Amount of debt guarantee directly or indirectly provided to a guaranteed 194,335.71 party with an asset-liability ratio exceeding 70% (D) Portion of total guaranteed amount exceeding 50% of net assets (E) 0.00 Total guaranteed amount of the above three items (C+D+E) 194,335.71 Statement on the contingent joint liability that might be assumed in N/A connection with outstanding guarantee The above connected guarantees are detailed in Note X 5(4) to the Financial Statements of Statement on guarantees this report. (III) Entrusted cash asset management 1. Entrusted wealth management (1) Overall situation of entrusted wealth management □Applicable √N/A Other information □Applicable √N/A (2) Single entrusted wealth management □Applicable √N/A 133 Joincare Pharmaceutical Group Annual Report 2022 Other information □Applicable √N/A (3) Provision for impairment of entrusted wealth management products □Applicable √N/A 2. Entrusted loans (1) Overall situation of entrusted loans □Applicable √N/A Other information □Applicable √N/A (2) Single entrusted loans □Applicable √N/A Other information □Applicable √N/A (3) Provision for impairment of entrusted loans □Applicable √N/A 3. Other information □Applicable √N/A (IV) Other material contracts □Applicable √N/A XIV. Other significant matters having significant influence on the value judgment and decisions of investors √Applicable □N/A 1. Use of proceeds Pursuant to the Reply to the Approval of Share Allotment of Joincare Pharmaceutical Group Industry Co., Ltd. issued by CSRC (Zheng Jian Xu Ke [2018] No. 1284), the Company allotted 365,105,066 shares to original shareholders. The planned proceeds from the share allotment amounted to RMB2,000 million; the total actual proceeds amounted to RMB1,715.9938 million; after deducting distribution expenses of RMB46.2536 million, the net proceeds amounted to RMB1,669.7402 million. As at 16 October 2018, the said proceeds were in place and validated by the Capital Verification Report of Joincare Pharmaceutical Group Industry Co., Ltd. issued by Ruihua Certified Public Accountants (Rui Hua Yan Zi [2018] No. 40060006). 134 Joincare Pharmaceutical Group Annual Report 2022 (1) Temporary replenishment of working capital by use of proceed Pursuant to the Resolution on the Temporary Replenishment of Working Capital with Idle Proceeds considered and approved at the 7th Meeting of the 8th Session of the Board of the Company on 30 December 2021, it was agreed that the Company temporarily replenished the working capital with no more than RMB700 million of idle proceeds from 1 January 2022 to 31 December 2022 so as to improve the use efficiency of proceeds and reduce financial expenses of the Company. For details, please refer to the Announcement on the Temporary Replenishment of Working Capital with Certain Idle Proceeds of Joincare Pharmaceutical Group Industry Co., Ltd. (Lin 2021-159). On 21 December 2022, the Company returned the temporary replenishment of working capital of RMB700 million to the special account, and the period of use did not exceed 12 months. Pursuant to the Resolution on the Temporary Replenishment of Working Capital with Idle Proceeds considered and approved at the 21st Meeting of the 8th Session of the Board and the 18th Meeting of the 8th Session of the Supervisory Committee of the Company on 29 December 2022, it was agreed that the Company temporarily replenished the working capital with no more than RMB500 million of idle proceeds from 1 January 2023 to 31 December 2023 so as to improve the use efficiency of proceeds and reduce financial expenses of the Company. For details, please refer to the “Announcement on the Temporary Replenishment of Working Capital with Certain Idle Proceeds of Joincare Pharmaceutical Group Industry Co., Ltd.” (Lin 2022-146). (2) Change of projects invested with proceeds Pursuant to the Resolution on Change of Certain Projects Invested with Proceeds considered and approved at the 8th Meeting of the 8th Session of the Board of the Company on 24 January 2022, it was agreed that Zhuhai Health Industry Base Construction Project was changed to the New Product R&D Project, Haibin Pharma Pingshan Pharmaceutical Industrialization Base Expansion Project and the Information Platform Construction Project. The resolution was approved at the 2022 1st extraordinary general meeting of the Company on 11 February 2022. For details of the aforesaid change of projects invested with proceeds, see the “Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on Change of Certain Projects Invested with Proceeds” (Lin 2022-007). Meanwhile, based on the aforesaid change of projects invested with proceeds, the Company, Taitai Pharmaceutical, a wholly-owned subsidiary of the Company, Haibin Pharma and Joincare Haibin, together with Minsheng Securities Co., Ltd., signed the “Three-party Supervision Agreement for Deposit into the Special Account for the Proceeds” 《募集资金专户存储三方监管协议》 with China Merchants Bank Co., Ltd. (Shenzhen Branch), Industrial Bank Co., Ltd. (Shenzhen Bagualing Sub-branch), Industrial and Commercial Bank of China Limited (Shenzhen Hongwei Sub-branch) and China Everbright Bank Co., Ltd. (University Town of Shenzhen Sub-branch), respectively. For details, please refer to the “Announcement on the Signing of the Three-party Supervision Agreement for Deposit into the Special Account for the Proceeds of Joincare Pharmaceutical Group Industry Co., Ltd.” (《健康元 135 Joincare Pharmaceutical Group Annual Report 2022 药业集团股份有限公司关于签订募集资金专户存储三方监管协议的公告》) (Lin 2022-015). For details about deposit and actual use of proceeds in 2022, please refer to the Special Report of Joincare Pharmaceutical Group Industry Co., Ltd. on Deposit and Actual Use of Proceeds in 2022 disclosed by the Company on 11 April 2023. 2. Matters about share repurchase (1) First share repurchases in 2022 Pursuant to the Resolution on Share Repurchase Scheme by Way of Centralized Bidding Transactions and other resolutions considered and approved at the 6th Meeting of the 8th Session of the Board and the 2021 Fifth Extraordinary General Meeting of the Company on 6 December 2021 and 23 December 2021, it was approved that the Company repurchased company shares by way of centralized bidding transactions with its own funds, and the repurchased shares will be used to reduce the registered capital; the total amount of repurchase funds should be no less than RMB300 million (inclusive) and no more than RMB600 million (inclusive); the repurchase price should be no more than RMB15/share (inclusive); the repurchase term should be no more than 12 months from the date when the repurchase scheme was approved by the General Meeting of the Company. For details, please refer to the “Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on the Share Repurchase Scheme by Way of Centralized Bidding Transactions (Lin 2021- 145)” and the “Repurchase Report of Joincare Pharmaceutical Group Industry Co., Ltd. on Share Repurchase by Way of Centralized Bidding Transactions” (Lin 2022-002). On 7 July 2022, the Company completed the repurchase and has repurchased a total of 50,959,668 shares by way of centralized bidding transactions, representing 2.66% of total share capital (1,912,540,667 shares) of the Company. The highest purchase price was RMB13.02/share, the lowest, RMB10.02/share, and the average, RMB11.77/share. The total amount paid was RMB599,981,715.83 (including handling fee), and 50,959,668 shares repurchased were cancelled on 11 July 2022. For details, please refer to the “Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on Implementation Results of Share Repurchase and Share Changes” (Lin 2022-076). (2) Second share repurchases in 2022 Pursuant to the Resolution on Share Repurchase Scheme by Way of Centralized Bidding Transactions and other resolutions considered and approved at the 17th Meeting of the 8th Session of the Board and the 2022 Fourth Extraordinary General Meeting of the Company on 14 October 2022 and 18 November 2021, it was approved that the Company repurchased company shares by way of centralized bidding transactions with its own funds, and the repurchased shares will be used to reduce the registered capital; the total amount of repurchase funds should be no less than RMB300 million (inclusive) and no more than RMB600 million (inclusive); the repurchase price should be no more than RMB16/share (inclusive); the repurchase term should be from 18 November 2022 to 17 November 2023. For details, please refer to the “Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on the Share Repurchase Scheme by Way of Centralized 136 Joincare Pharmaceutical Group Annual Report 2022 Bidding Transactions” (Lin 2022- 121) and the “Repurchase Report of Joincare Pharmaceutical Group Industry Co., Ltd. on Share Repurchase by Way of Centralized Bidding Transactions” (Lin 2022-137). On 14 December 2022, the Company initially repurchased 348,400 shares by way of centralized bidding transactions, representing 0.02% of the total share capital of the Company. For details, please refer to the “Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on Initial Share Repurchase by Way of Centralized Bidding Transactions” (Lin 2022-144). As of 31 March 2023, the Company has repurchased a total number of 40,662,579 shares by way of centralized bidding transactions, representing 2.11% of the total share capital (1,929,189,374) of the Company. The total amount paid was RMB494.4911 million (including handling fee). For details, please refer to the Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on the Progress of Share Repurchase by Way of Centralized Bidding Transactions (Lin 2023-027). 3. GDRs of the Company was issued and listed on the SIX Swiss Exchange Pursuant to the “Resolution on the Planning of Overseas Issuance of GDRs and Listing on the SIX Swiss Exchange of the Company” (《关于公司筹划境外发行全球存托凭证并在瑞士证券交易所上市的议 案》) considered and approved at the 12th Meeting of the 8th Session of the Board of the Company on 15 June 2022. In order to broaden the Company’s international financing channels and enhance its international brand and image, the Company intends to plan to issue Global Depositary Receipts (“GDRs”) overseas and list on the SIX Swiss Exchange. For details, please refer to the “Reminder Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on the Planning of Overseas Issuance of GDRs and Listing on the SIX Swiss Exchange” (《健康元药业集团股份有限公司关于筹划境外发行全球存托凭 证并在瑞士证券交易所上市的提示性公告》) (Lin 2022-061). Pursuant to the “Resolution on the Issuance of GDRs and Listing on the SIX Swiss Exchange and the Conversion of the Company into a Company Limited by Shares that Issues and Lists Its Shares Abroad” (《关于公司发行 GDR 并在瑞士证券交易所上市及转为境外募集股份有限公司的议案》), the “Resolution on the Company’s Plan of the Issuance of GDRs and Listing on the SIX Swiss Exchange” (《关于公司发行 GDR 并在瑞士证券交易所上市方案的议案》) and other relevant resolutions considered and approved at the 13th Meeting of the 8th Session of the Board of the Company on 22 June 2022, the Company intends to issue GDRs representing newly issued RMB ordinary A Shares as underlying securities. The additional underlying A Shares represented by the GDRs to be issued shall be no more than 191,254,066 Shares (including securities issued upon the exercise of any overallotment option, if any) and shall not account for more than 10% of the Shares capital (1,912,540,667 Shares) of the Company prior to the issuance. The number of the additional underlying A Shares represented by the GDRs to be issued shall be adjusted according to relevant regulations if the share capital of the Company increases or decreases as a result of bonus issue, capitalization issue or rights issue, share repurchase etc. during the period from the date of approval of the issuance by the Board to the issuance date. The Company has simultaneously formulated the “Confidentiality and Records Management System for Overseas Issuance of Securities and 137 Joincare Pharmaceutical Group Annual Report 2022 Listing of Joincare Pharmaceutical Group Industry Co., Ltd.” (《健康元药业集团股份有限公司境外发 行证券与上市相关保密和档案管理工作制度》) and amended the “Articles of Association”, the “Rules of Procedure for the Shareholders’ General Meetings” and other relevant company rules and regulations in relation to GDRs. For details, please refer to the “Announcement on Resolutions Considered and Approved at the 13th Meeting of the 8th Session of the Board of Joincare Pharmaceutical Group Industry Co., Ltd.” ( 《 健 康 元药 业 集团 股 份有 限 公 司八 届 董事 会 十三 次 会 议决 议 公告 》 ) (Lin 2022-063), the “Confidentiality and Records Management System for Overseas Issuance of Securities and Listing of Joincare Pharmaceutical Group Industry Co., Ltd.” (《健康元药业集团股份有限公司境外发行证券与 上市相关保密和档案管理工作制度》) and the “Announcement on the Formulation of the Articles of Association and its Annexes Applicable to the Company upon the Listing of GDRs of Joincare Pharmaceutical Group Industry Co., Ltd.” (《健康元药业集团股份有限公司关于制定公司 GDR 上市 后适用的《公司章程》及其附件的公告》(Lin 2022-064). On 8 July 2022, the Company held the 2022 Second Extraordinary General Meeting to consider and approve the aforesaid resolutions for the issuance of GDRs and listing in Switzerland and to request the general meeting of the Company to authorize the Board and its authorized persons to deal with matters relating to the issuance of GDRs and listing in full, as detailed in the “Announcement on Resolutions of Joincare Pharmaceutical Group Industry Co., Ltd. at the 2022 Second Extraordinary General Meeting” (Lin 2022- 077). On 19 August 2022, the Company obtained the conditional approval for the issuance and listing of GDRs on the SIX Swiss Exchange from SIX Exchange Regulation AG, and the SIX Swiss Exchange Regulation AG agreed to the listing of the Company’s GDRs on the SIX Swiss Exchange subject to the satisfaction of customary conditions. On 2 September 2022, the Company received the “Approval for the Initial Public Offering and Listing of Global Depositary Receipts on the SIX Swiss Exchange by Joincare Pharmaceutical Group Industry Co., Ltd.” (《关于核准健康元药业集团股份有限公司首次公开发行全球存托凭证并在瑞士证券交 易所上市的批复》) (Zheng Jian Xu Ke [2022] No. 1960) granted by the CSRC. On 26 September 2022, the Company’s GDRs were listed on the SIX Swiss Exchange in an offering of 6,382,500 GDRs representing 63,825,000 underlying A shares, representing 3.31% of the Company’s total share capital at that time, at an issue price of USD$14.42 per GDR, with the final gross proceeds of approximately USD$92.04 million. The lock-up restriction period for the redemption of the GDRs issued by the Company is from 26 September 2022 (Swiss time) to 23 January 2023 (Swiss time). As 23 January 2023 falls in the Chinese New Year holiday, the transfer and settlement of A shares in relation to the cross-border conversion of GDRs cannot proceed during the period from 23 January to 27 January 2023. In accordance with the relevant regulations on stock connect, the GDRs with the expiry of the lock-up restriction period for the redemption can be converted into A shares of the Company from 30 January 2023 (Beijing time). As of 138 Joincare Pharmaceutical Group Annual Report 2022 the closing of the Shanghai Stock Exchange on 30 January 2023, the number of A shares of the Company represented by the outstanding GDRs was less than 50% of the number of underlying A shares represented by the GDRs actually issued by the Company as approved by the CSRC. The proceeds from the Company’s issuance of GDRs, after deducting the issuance fees, are intended for the business development and strategic investment of the Company, aimed at improving the Company's capabilities of global research and development, industrialization and commercialization, thus further deepening the international business presence and replenishing the working capital of the Company. As of the end of this Reporting Period, the proceeds from the Company’s issuance of GDRs have not been used. 4. Overall relocation and expansion project of Sichuan Guangda On 6 March 2019, the board of directors of Livzon Group, the controlling subsidiary of the Company, considered and approved that Livzon Group entered into the Investment Agreement for the “Overall Relocation and Expansion Project of Sichuan Guangda Pharmaceutical Manufacturing” (《四川光大制药 整体搬迁调迁扩建项目投资协议书》) (the “Investment Agreement”) and the “Supplemental Agreement I with Sichuan Chengdu Pengzhou Municipal People's Government” (四川省成都市彭州市人民政府). Pursuant to the Investment Agreement, the Company will inject capital of RMB646 million for investment in construction of the overall relocation and expansion project (the “Project”) of Sichuan Guangda, a wholly-owned subsidiary of the Company. Pursuant to the Supplemental Agreement I, Pengzhou Municipal People's Government has agreed to pay a compensation for demolition of RMB90 million and grant total incentive of not more than RMB125.8 million for the construction of new plants to the Company. As at 31 December 2022, the total investment of the Project under specific contracts amounted to RMB542.2556 million, and subsidies received from governments at all levels totaled RMB138.9817 million. After the QC decoration and renovation, equipment installation and warehousing system establishment, the equipment was put into running for commissioning and the storage system was delivered for acceptance; after the decoration, renovation and equipment installation of the extraction workshop and after the pre- treatment workshop were completed, the equipment was put into running for commissioning and the remaining work of local decoration was completed. The construction of the granulation workshop, the integrated preparation workshop and the packaging workshop commenced, the remaining work of the decoration and renovation of the alcohol extraction workshop was completed, and the pipeline equipment had not installed for commissioning. The overall project went smoothly. 5. Progress of the initial public offering and listing of shares of Tianjin Tongrentang, a non- controlling invested company The Shenzhen Stock Exchange has suspended the review of listing of Tianjin Tongrentang on 26 January 2022, as CSRC has initiated an investigation against ShineWing Certified Public Accountants (Special General Partnership), the audit institution engaged by Tianjin Tongrentang for the initial public offering of its shares and listing on the ChiNext Board. 139 Joincare Pharmaceutical Group Annual Report 2022 Considering that ShineWing Certified Public Accountants (Special General Partnership), the auditor appointed by Tianjin Tongrentang, has issued a review report, the Shenzhen Stock Exchange has resumed the review of the listing of Tianjin Tongrentang on 30 March 2022. In addition to the above disclosure, details of the non-controlling invesmtnet in Tianjin Tongrentang are set out in the Company’s annual report for 2021. 6. Progress of Livzon Group's plan to spin off Livzon Diagnostics for A-share listing On 7 August 2020, the board of directors of Livzon Group, a majority-controlled subsidiary of the Company, considered and approved the proposal to spin off its subsidiary Zhuhai Livzon Diagnostics Inc. for A-share listing (hereinafter referred to as spin-off listing). Livzon Diagnostics is mainly engaged in the R&D, production and sale of diagnostic reagents and equipment. As at the End of the Reporting Period, Livzon Group held approximately 39.425% of shares of Livzon Diagnostics. After completion of this spin-off, the shareholding structure of Livzon Group will remain unchanged, and Livzon Group will still maintain control over Livzon Diagnostics. For details, see the “Suggestive Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on Livzon Group's Planned Spin-off of Its Subsidiary Livzon Diagnostics for A-share Listing” (Lin 2020-106). On 16 October 2020, the Stock Exchange of Hong Kong Limited agreed to Livzon Group's spin-off listing, and agreed to exempt the group from the applicable regulations concerning the assured entitlement related to the spin-off listing. For details, see the “Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on the Progress of Livzon Group's Planned Spin-off of Its Subsidiary Livzon Diagnostics for A-share Listing” (Lin 2020-131). Livzon Diagnostics would go spin-off listing on the ChiNext Board of Shenzhen Stock Exchange pursuant to the Resolution on the Spin-off of the Subsidiary Zhuhai Livzon Diagnostics Inc. to Go Listing on the ChiNext Board of Shenzhen Stock Exchange considered and approved at the board meeting of Livzon Group on 23 October 2020. For details, see the “Announcement of Joincare Pharmaceutical Group Industry Co., Ltd. on the Progress of Livzon Group's Planned Spin-off of Its Subsidiary Livzon Diagnostics for A- share Listing” (Lin 2020-134). The spin-off listing of Livzon Diagnostics was approved at the 2020 4th extraordinary general meeting of Livzon Group on 20 November 2020, and was registered with Guangdong Securities Regulatory Bureau for pre-listing tutoring in November 2020. As of the disclosure date of this report, Livzon Diagnostics has submitted the nine issues of reports on progress of the tutoring. As of the disclosure date of this report, Livzon Diagnostics has not submitted any application to or registered with Shenzhen Stock Exchange or any relevant Chinese regulatory authorities other than those progresses listed above. 140 Joincare Pharmaceutical Group Annual Report 2022 Chapter 7 Changes in Equity and Shareholders I. Changes in Share Capital (I) Table of changes in shares 1. Table of changes in shares Unit: shares Before the current change Increase/decrease (+, -) due to the current change After the current change Conversion Issuance Percentage Issuance of of capital Percentage Number of bonus Others Subtotal Number (%) new shares reserve to (%) shares share capital I. Shares subject to 0 0 0 0 0 0 0 0 0 selling restrictions 1. Shares held by state government 2. Shares held by state-owned entities 3. Shares held by other domestic holders Of which: Shares held by domestic non-state-owned entities Shares held by domestic natural persons 4. Shares held by foreign holders Including: Shares held by foreign entities Shares held by foreign natural persons II. Shares without 1,907,727,908 100 72,421,134 0 0 -50,959,668 21,461,466 1,929,189,374 100 selling restrictions 1. Ordinary shares denominated in 1,907,727,908 100 72,421,134 0 0 -50,959,668 21,461,466 1,929,189,374 100 Renminbi 2. Domestically listed foreign shares 3. Overseas listed foreign shares 4. Others III. Total number 1,907,727,908 100 72,421,134 0 0 -50,959,668 21,461,466 1,929,189,374 100 of shares 2.Explanations on changes in shares √Applicable □N/A (1) Share repurchase for cancellation From 24 December 2021 to 23 December 2022, the Company expected to repurchase shares at a price of no more than RMB15 per share (inclusive) and the total amount of repurchase funds shall be not less than 141 Joincare Pharmaceutical Group Annual Report 2022 RMB300 million (inclusive) and not more than RMB600 million (inclusive). The repurchased shares will be used to reduce the Company's registered capital. The Company has repurchased a total of 50,959,668 shares as of 7 July 2022, and cancelled such shares with the Shanghai Branch of China Securities Depository and Clearing Corporation Limited on 11 July 2022. (2) Issuance of GDRs The Company held the 2022 second extraordinary general meeting on 8 July 2022, at which it reviewed and approved the Resolution on the Company’s Issuance of GDRs, Listing on the SIX Swiss Exchange and Conversion into a Joint Stock Limited Company Offering Shares Overseas (《关于公司发行 GDR 并在瑞士证券交易所上市及转为境外募集股份有限公司的议案》) and other relevant resolutions. 6,382,500 GDRs were issued by the Company, representing 63,825,000 underlying A shares, with one GDR represents 10 A Shares of the Company, and were listed on the SIX Swiss Exchange on 26 September 2022. The total share capital of the Company increased by 63,825,000 shares as a result of the issuance and listing of the GDRs mentioned above. (3) Exercise of the 2018 share options The third exercise period for the options first granted under the Company's 2018 Share Options Incentive Plan commenced on 21 December 2021, namely from 21 December 2021 to 20 December 2022. The second exercise period for the reserve options commenced on 23 September 2021, namely from 23 September 2021 to 22 September 2022. During the Reporting Period, the cumulative number of share options exercised and completing share transfer registration was 8,596,134. 3.The influence of changes in shares on financial indicators such as earnings per share and net assets per share in the most recent year and the most recent Reporting Period (if applicable) □Applicable √N/A 4.Other information disclosed as the Company deems necessary or required by the securities regulatory authority □Applicable √N/A (II) Changes in shares subject to selling restrictions □Applicable √N/A II. Issuance and Listing of Securities (I) Securities issued during the Reporting Period □Applicable √N/A Explanations on securities issuance during the Reporting Period (list separately bonds with different interest rates during the duration): □Applicable √N/A 142 Joincare Pharmaceutical Group Annual Report 2022 (II) Changes in total number of shares, shareholding structure, and structure of assets and liabilities of the Company □Applicable √N/A (III) Outstanding shares granted under the employee share ownership scheme □Applicable √N/A III. Information on Shareholders and the De Facto Controller (I) Total number of shareholders Total number of shareholders of ordinary shares as of the End of the 93,510 Reporting Period Total number of shareholders of ordinary shares as of the end of the 87,173 month immediately prior to the publish date of this annual report (II) Shares held by top 10 shareholders and top 10 holders of tradable shares (or shares without selling restrictions) as of the End of the Reporting Period Unit: shares Shareholdings of the Top 10 shareholders Number of Pledge, mark or lock-up Change Number of shares Name of shareholder (Full during the shares held at Percentage held Nature of name) Reporting the end of the (%) subject to Share status Number shareholder Period Period selling restrictions Shenzhen Baiyeyuan Domestic Investment Co., Ltd.* (深圳市 -17,380,900 878,272,753 45.53 0 Pledge 95,679,725 non-state- 百业源投资有限公司) owned entity Hong Kong Securities Clearing 21,294,741 113,256,167 5.87 0 Unknown Unknown Company Limited Foreign Citibank, National Association 63,825,000 63,825,000 3.31 0 Unknown entity Foreign Might Seasons Limited -14,371,900 57,487,434 2.98 0 Unknown entity Huaxia Life Insurance Co., Ltd. 163,100 9,275,718 0.48 0 Unknown Unknown - Equity fund Agricultural Bank of China Limited - CSI 500 Exchange 2,663,000 8,060,294 0.42 0 Unknown Unknown Traded Index Securities Investment Fund Domestic He Zhong -50,000 7,800,024 0.40 0 Unknown natural person Joincare Pharmaceutical Group Industry Co., Ltd. — the Second Phase Ownership 6,275,372 6,275,372 0.33 0 Unknown Others Scheme under Medium to Long-term Business Partner Share Ownership Scheme Abu Dhabi Investment Foreign 4,808,605 5,920,342 0.31 0 Unknown Authority entity 143 Joincare Pharmaceutical Group Annual Report 2022 Bosera Funds Management Co., Ltd. - 419 portfolio of -3,696,377 5,036,569 0.26 0 Unknown Unknown social security funds Shareholdings of the Top 10 shareholders without selling restrictions Number of tradable shares held Class and number of shares Name of shareholder without selling restrictions Class Number Shenzhen Baiyeyuan Investment Co., Ltd.* (深圳 878,272,753 Ordinary shares denominated in Renminbi 878,272,753 市百业源投资有限公司) Hong Kong Securities Clearing Company Limited 113,256,167 Ordinary shares denominated in Renminbi 113,256,167 Citibank, National Association 63,825,000 Ordinary shares denominated in Renminbi 63,825,000 Might Seasons Limited 57,487,434 Ordinary shares denominated in Renminbi 57,487,434 Huaxia Life Insurance Co., Ltd. - Equity fund 9,275,718 Ordinary shares denominated in Renminbi 9,275,718 Agricultural Bank of China Limited - CSI 500 Exchange Traded Index Securities Investment 8,060,294 Ordinary shares denominated in Renminbi 8,060,294 Fund He Zhong 7,800,024 Ordinary shares denominated in Renminbi 7,800,024 Joincare Pharmaceutical Group Industry Co., Ltd. — the Second Phase Ownership Scheme under 6,275,372 Ordinary shares denominated in Renminbi 6,275,372 Medium to Long-term Business Partner Share Ownership Scheme Abu Dhabi Investment Authority 5,920,342 Ordinary shares denominated in Renminbi 5,920,342 Bosera Funds Management Co., Ltd. - 419 5,036,569 Ordinary shares denominated in Renminbi 5,036,569 portfolio of social security funds As at the End of the Reporting Period, the special repurchase account of the Company (special Notes on the special repurchase account among securities repurchase account of Joincare Pharmaceutical Group Industry Co., Ltd.) owned 28,417,048 the Top 10 shareholders shares in total, accounting for 1.47%. Description of the above shareholders involved in entrustment/entrusted voting right and waiver of Not applicable voting right There was no connection or acting-in-concert relationship between Shenzhen Baiyeyuan Investment Description of connection or acting-in-concert Co., Ltd., a controlling shareholder of the Company, and other shareholders; whether there is connection relationship of the above shareholders or acting-in-concert relationship among other shareholders is unknown. Notes: 1. As of the End of the Reporting Period, the balance of shares lent by Shenzhen Baiyeyuan Investment Co., Ltd. * (深圳市百业源投资有限公司), a controlling shareholder of the Company, by participating in the refinancing business was 17,380,900, and the ownership transfer of such shares does not take place. 2. Citibank, National Association is the depositary for GDRs of the Company, and the underlying domestic A shares represented by the GDRs are registered in its name according to law. The GDRs issued by the Company may not be converted into A shares from 26 September 2022 (Swiss time) to 23 January 2023 (Swiss time). Number of shares held by the Top 10 shareholders with selling restrictions and the description of the selling restrictions □Applicable √N/A (III) Strategic investors or general legal persons who became top 10 shareholders as a result of allotment of new shares □Applicable √N/A 144 Joincare Pharmaceutical Group Annual Report 2022 IV. Information on the Controlling Shareholder and the De Facto Controller (I) Information on the Controlling shareholder 1. Legal person √Applicable □N/A Name Shenzhen Baiyeyuan Investment Co., Ltd.* (深圳市百业源投资有限公司) Person in charge of the unit or legal Zhu Baoguo representative Date of incorporation 21 January 1999 Investment in industry, domestic commerce, and material supply and Principal business marketing industry Equity held in other domestic and Except for the daily trading of securities assets in the secondary market, overseas listed companies during the Baiyeyuan did not hold or participate in the equity of other domestic and Reporting Period overseas listed companies during the Reporting Period. Others Not applicable 2.Natural person □Applicable √N/A 3.Special statement if the Company does not have a controlling shareholder □Applicable √N/A 4.Statement on changes in controlling shareholders during the Reporting Period □Applicable √N/A 5.Block diagram describing controlling shareholders' ownership of and control over the Company √Applicable □N/A Note: As of the End of the Reporting Period, the balance of shares lent by Shenzhen Baiyeyuan Investment Co., Ltd. * (深 圳市百业源投资有限公司), a controlling shareholder of the Company, by participating in the refinancing business was 17,380,900, and the ownership transfer of such shares does not take place. (II) Information on the de facto controller 1.Legal person □Applicable √N/A 145 Joincare Pharmaceutical Group Annual Report 2022 2.Natural person √Applicable □N/A Name Zhu Baoguo Nationality China Hold the right of residence in other countries No or regions or not Main occupation and position Chairman of the Company and Livzon Group Domestic and overseas listed companies Except for the Company and Livzon Group, Mr. Zhu Baoguo has never controlled in the past 10 years controlled any other domestic and overseas listed companies 3.Special statement if the Company does not have a de facto controller □Applicable √N/A 4.Statement on change of control of the Company during the Reporting Period □Applicable √N/A 5.Block diagram describing de facto controllers' ownership of and control over the Company √Applicable □N/A Note: As of the End of the Reporting Period, the balance of shares lent by Shenzhen Baiyeyuan Investment Co., Ltd. * (深 圳市百业源投资有限公司), a controlling shareholder of the Company, by participating in the refinancing business was 17,380,900, and the ownership transfer of such shares does not take place. 6.De facto controller controls the Company through trust or other asset management methods □Applicable √N/A (III) Other information on the controlling shareholder and the de facto controllers □Applicable √N/A V. Cumulative Number of Shares Pledged by Controlling Shareholders or the Largest Shareholder of the Company and Their Persons Acting in Concert Accounts for More Than 80% of the Shares Held by Them in the Company □Applicable √N/A 146 Joincare Pharmaceutical Group Annual Report 2022 VI. Other Corporate Shareholders Holding More Than 10% Shares □Applicable √N/A VII. Explanation on Restrictions on Share Selling □Applicable √N/A VIII. Information on Implementation of Share Repurchases Plans during the Reporting Period √Applicable □N/A Unit: 10,000 Yuan Currency: RMB Name of share repurchase plan Plan on share repurchase by centralized bidding Disclosure date of share repurchase plan 7 December 2021 Number of shares to be repurchased and its 1.05~2.10 percentage in total share capital (%) Proposed repurchase amount 30,000~60,000 12 months after the date when the share repurchase plan is Proposed repurchase period approved at the general meeting Purpose of repurchase To reduce registered capital of the Company Repurchased number (shares) 50,959,668 Percentage of repurchased shares in the target shares Not applicable under share incentive scheme (%) (if any) The progress of the Company's reduction of Not applicable repurchased shares by centralized bidding Remarks On 11 July 2022, 50,959,668 repurchased shares were cancelled. Name of share repurchase plan Plan on share repurchase by centralized bidding Disclosure date of share repurchase plan 17 October 2022 Number of shares to be repurchased and its 0.97~1.95 percentage in total share capital (%) Proposed repurchase amount 30,000~60,000 12 months after the date when the share repurchase plan is Proposed repurchase period approved at the general meeting Purpose of repurchase To reduce registered capital of the Company Repurchased number (shares) 10,957,235 Percentage of repurchased shares in the target shares Not applicable under share incentive scheme (%) (if any) The progress of the Company's reduction of Not applicable repurchased shares by centralized bidding 147 Joincare Pharmaceutical Group Annual Report 2022 Chapter 8 Information on Preferred Shares □Applicable √N/A 148 Joincare Pharmaceutical Group Annual Report 2022 Chapter 9 Information on Bonds I. Corporate Bonds, Debentures and Debt Financing Instruments Issued by Non-Financial Entities □Applicable √N/A II. Convertible Corporate Bonds □Applicable √N/A 149 Joincare Pharmaceutical Group Annual Report 2022 Chapter 10 Financial Statements I Auditor’s report √Applicable □N/A GTCNSZ(2023)NO.442A008607 To all shareholders of Joincare Pharmaceutical Group Industry Co., Ltd.: I. Auditor's Opinion We have audited the financial statements of Joincare Pharmaceutical Group Industry Co., Ltd. (健康元药业集团股份有限公司) (the “Group”), which comprise the Consolidated and Company balance sheets as at 31 December 2022, and the Consolidated and Company income statements, the Consolidated and Company cash flow statements, the Consolidated and Company statements of changes in shareholders' equity for the year ended 2022, and notes to the financial statements. In our opinion, the accompanying financial statements present fairly, in all material respects, the Consolidated and Company financial positions as at 31 December 2022, and their financial performance and their cash flows for the year then ended in accordance with the requirements of Accounting Standards for Business Enterprises. II. Basis for Opinion We conducted our audit in accordance with China Standards on Auditing. Our responsibilities under those standards are further described in the Auditor's Responsibilities for the Audit of the Financial Statements section of our report. We are independent of the Company and have fulfilled our other ethical responsibilities in accordance with the China Code of Ethics for Certified Public Accountants. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion. III. Key Audit Matters Key audit matters are those matters that, in our professional judgment, were of most significance in our audit of the financial statements for the current year. These matters were addressed in the context of our audit of the financial statements as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters. (I) Revenue recognition For relevant disclosure, please refer to Note III. 28 and Note V. 43 to the financial statements. 1. Description of the matter The Group generated revenue from primary operation in year ended 31 December 2022 were RMB 17,036.97 million. We identified revenue recognition as a key audit matter due 150 Joincare Pharmaceutical Group Annual Report 2022 to the materiality of revenue to the financial statements as a whole and the risk of material misstatement as to the occurrence and accuracy for in the appropriate accounting period. 2. Addressed in the context of our audit (1) We obtained an understanding of and assessed the Company management's design and operating effectiveness of key internal controls over revenue recognition. (2) We obtained the contracts signed between the Company and its customers and verified the key terms of the contracts, such as shipment and acceptance, payment and settlement, exchange and return policies. (3) We inquired about the business registration information of the Company's customers and asked relevant personnel of the Company in order to confirm whether there was an affiliated relationship between the Company and its customers; obtained an understanding of the reasons for customer changes and contract performance among others; counted and analyzed end sales of products purchased by selected customers from the Company based on the business system of the Company's directly connected customers. (4) We obtained records of returns and exchanges in the Company's business system and checked them to confirm whether there were significant abnormalities that affected revenue recognition. (5) For revenue transactions recorded in the year ended 31 December 2022, we selected samples to check contracts, purchase orders, shipping documents, transportation documents, bookkeeping vouchers, payback documents, periodic reconciliation letters and other supporting documents; and selected samples to perform external confirmation procedures on major customer sales and accounts receivable. (6) We performed analytical procedures for the reasonableness on changes in revenue by considering the product type and factors such as market trends, industry trends, business expansion plan as well as market data collected by third-party consultants. (7) We selected samples of revenue transactions around the balance sheet date, reviewed sales contracts, purchase orders, shipping documents, transportation documents, and bookkeeping vouchers, and evaluated whether revenues were recorded in the appropriate accounting period. (II) Allowance for bad debts on accounts receivable For relevant disclosure, please refer to Note III. 10 and Note V. 4 to the financial statements 1. Description of the matter As of 31 December 2022, the Group's closing balance of accounts receivable as reported in the consolidated balance sheet was RMB 3,176.23 million and the allowance for bad debts was RMB 72.48 million which were material to the financial statements as a whole. The management is required to apply significant accounting estimates and judgments in assessing the expected recoverable amount of accounts receivable, which could have a material impact on the financial statements if they were not collected on time or were not recovered resulting in a bad debt loss. Therefore, we identified allowance for bad debts of accounts receivable as a key audit matter. 2. Addressed in the context of our audit 151 Joincare Pharmaceutical Group Annual Report 2022 (1) We obtained an understanding of and assessed the management's design and operating effectiveness of key internal controls over the management of accounts receivable (2) We obtained an understanding of the methodology and process of recognizing the expected credit loss ratio and the key parameters and assumptions applied in the expected credit loss model, including the method of assessing the customers' credit risk characteristics for the grouping accounts receivable and the historical migration rate data used in the expected loss ratio; evaluated whether the expected credit loss ratio was set by taking into account and was appropriately adjusted for current economic conditions and forward-looking information, and assessed the reasonableness of the estimate of the allowance for bad debts. (3) We obtained a schedule of allowance for bad debts on accounts receivable and checked whether the calculation method was implemented in accordance with the policy for bad debts; and recalculated the amount of allowance for bad debts to ensure its accuracy. (4) We analysed the ratio of the closing balance of allowance for bad debts to accounts receivable and compared the allowance for bad debts in the previous period to the actual amount, and analyzed whether the allowance for bad debts on accounts receivable was adequate. (5) We evaluated the reasonableness of the allowance for bad debts by analyzing the aging of accounts receivable and the reputation of customers, and performing audit procedures such as audit confirmation and subsequent collection of receivables. IV. Other Information Management of the Company is responsible for the other information. The other information comprises the information included in the Company’s 2022 annual report, but does not include the financial statements and our auditor's report thereon. Our opinion on the financial statements does not cover the other information and we do not express any form of assurance conclusion thereon. In connection with our audit of the financial statements, our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact. We have nothing to report in this regard. V. Responsibilities of Management and Those Charged with Governance for the Financial Statements Management of the Company is responsible for the preparation of the financial statements to achieve fair presentation in accordance with Accounting Standards for Business Enterprises, and for the design, implementation and maintenance of such internal control as management determine is necessary to enable the preparation of the financial statements that are free from material misstatement, whether due to fraud or error. 152 Joincare Pharmaceutical Group Annual Report 2022 In preparing the financial statements, management is responsible for assessing the Company's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless management either intend to liquidate the Company or to cease operations, or have no realistic alternative but to do so. Those charged with governance are responsible for overseeing the Company's financial reporting process. VI. Auditor's Responsibilities for the Audit of the Financial Statements Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor's report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with auditing standards will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements. As part of an audit in accordance with auditing standards, we exercise professional judgment and maintain professional skepticism throughout the audit. We also: (1) Identify and assess the risks of material misstatement of the financial statements, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override of internal control. (2) Obtain an understanding of internal control relevant to the audit in order to design audit procedures that are appropriate in the circumstances. (3) Evaluate the appropriateness of accounting policies used and the reasonableness of accounting estimates and related disclosures made by management. (4) Conclude on the appropriateness of the management’s use of the going concern basis of accounting and, based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Company's ability to continue as a going concern. If we conclude that a material uncertainty exists, the auditing standards require us to draw attention to users of the financial statements in our auditor's report to the related disclosures in the financial statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor's report. However, future events or conditions may cause the Company to cease to continue as a going concern. (5) Evaluate the overall presentation, structure and content of the financial statements, including the disclosures, and whether the financial statements represent the underlying transactions and events in a manner that achieves fair presentation. (6) Obtain sufficient appropriate audit evidence regarding the financial information of the entities or business activities within the Company to express an opinion on the financial 153 Joincare Pharmaceutical Group Annual Report 2022 statements. We are responsible for the direction, supervision and performance of the group audit. We remain solely responsible for our audit opinion. We communicate with those charged with governance regarding, among other matters, the planned scope and timing of the audit and significant audit findings, including any significant deficiencies in internal control that we identify during our audit. We also provide those charged with governance with a statement that we have complied with relevant ethical requirements regarding independence, and to communicate with them all relationships and other matters that may reasonably be thought to bear on our independence, and where applicable, related safeguards. From the matters communicated with those charged with governance, we determine those matters that were of most significance in the audit of the financial statements of the current period and are therefore the key audit matters. We describe these matters in our auditor's report unless law or regulation precludes public disclosure about the matter or when, in extremely rare circumstances, we determine that a matter should not be communicated in our report because the adverse consequences of doing so would reasonably be expected to outweigh the public interest benefits of such communication. Grant Thornton(Special General Certified Public Accountants Wang Yuan Partnership) (The partner in charge of the auditing service project) Certified Public Accountants Wang Qilai Beijing, China 7 April 2023 154 Joincare Pharmaceutical Group Annual Report 2022 II Financial statements Consolidated Balance Sheet December 31, 2022 Prepared by: Joincare Pharmaceutical Group Industry Co., Ltd. Unit: Yuan Currency: RMB Item Note December 31, 2022 December 31, 2021 Current assets: Cash and bank balances V.1 14,808,488,110.96 11,729,230,390.98 Financial assets held for trading V.2 109,015,664.98 184,638,344.31 Notes receivable V.3 1,959,985,016.85 1,977,286,022.02 Accounts receivable V.4 3,103,758,850.15 2,853,655,551.54 Receivables financing Prepayments V.5 364,265,142.57 369,232,546.29 Other receivables V.6 52,535,740.14 88,053,825.12 In which: Interests receivable 365,873.64 Dividends receivable Inventories V.7 2,561,869,999.57 2,078,944,387.68 Contract assets Assets held-for-sale Non-current assets due within one year V.8 54,048,611.11 317,381.23 Other current assets V.9 163,539,900.32 83,986,214.37 Total current assets 23,177,507,036.65 19,365,344,663.54 Non-current assets: Debt investment Other debt investment Long-term receivables V.10 266,904.13 Long-term equity investment V.11 1,419,882,594.59 1,419,349,454.84 Other equity instrument investment V.12 1,193,958,879.05 1,408,882,377.42 Other non-current financial assets Investment properties V.13 6,191,475.43 6,191,475.43 Fixed assets V.14 5,265,200,110.91 4,839,005,169.81 Construction in progress V.15 811,300,068.96 742,998,743.75 Productive biological assets Oil and gas assets Right-of-use assets V.16 41,843,133.97 46,774,759.69 Intangible assets V.17 802,115,125.75 456,782,094.80 Development cost V.18 428,284,884.17 786,993,435.71 Goodwill V.19 614,468,698.73 614,468,698.73 Long-term prepaid expenses V.20 277,867,716.95 200,715,740.93 Deferred tax assets V.21 533,861,743.26 552,542,866.71 Other non-current assets V.22 1,156,772,182.99 663,584,003.80 Total non-current assets 12,551,746,614.76 11,738,555,725.75 Total assets 35,729,253,651.41 31,103,900,389.29 Current liabilities: Short-term loans V.23 2,126,050,615.06 2,518,484,835.09 Financial liabilities held for trading V.24 755,634.43 143,302.24 Notes payable V.25 1,635,906,989.22 1,582,386,767.93 Accounts payable V.26 943,905,580.91 871,553,210.51 Receipts in advance Contract liabilities V.27 292,977,730.74 234,140,702.29 Employee benefits payable V.28 573,010,571.46 475,430,823.20 Taxes payable V.29 337,702,273.73 270,618,183.41 Other payables V.30 3,680,334,360.88 3,292,407,989.79 155 Joincare Pharmaceutical Group Annual Report 2022 In which: Interests payable Dividends payable 12,252,074.84 6,951,984.46 Liabilities held-for-sale Non-current liabilities due within one year V.31 63,077,260.98 91,576,066.33 Other current liabilities V.32 101,276,714.35 15,626,224.29 Total current liabilities 9,754,997,731.76 9,352,368,105.08 Non-current liabilities: Long-term loans V.33 3,230,844,042.88 826,780,252.78 Bonds payable Lease liabilities V.34 23,482,486.07 25,071,794.32 Long-term payables Long-term payroll payable Estimated liabilities Deferred income V.35 384,537,267.55 433,543,352.40 Deferred tax liabilities V.21 231,164,425.48 208,525,905.39 Other non-current liabilities V.36 84,000,000.00 78,000,000.00 Total non-current liabilities 3,954,028,221.98 1,571,921,304.89 Total liabilities 13,709,025,953.74 10,924,289,409.97 Owner's equity (or shareholder's equity): Share capital V.37 1,929,189,374.00 1,907,727,908.00 Other equity instruments In which: Preferred shares Perpetual debts Capital reserve V.38 2,343,693,215.99 2,265,357,311.92 Less: Treasury shares V.39 347,176,561.29 222,644,454.50 Other comprehensive income V.40 4,704,473.53 5,387,545.97 Special reserve Surplus reserve V.41 734,766,581.50 640,821,179.08 Undistributed profits V.42 8,456,643,326.82 7,223,644,166.22 Total shareholders' equity attributable to the parent 13,121,820,410.55 11,820,293,656.69 Minority shareholder's equity 8,898,407,287.12 8,359,317,322.63 Total owner's equity (or shareholder's equity) 22,020,227,697.67 20,179,610,979.32 Total liabilities and owner's equity (or 35,729,253,651.41 31,103,900,389.29 shareholder's equity) Person-in-charge of the Company: Person-in-charge of the Company’s Person-in-charge of the accounting Zhu Baoguo accounting work: Qiu Qingfeng department: Qiu Qingfeng 156 Joincare Pharmaceutical Group Annual Report 2022 Balance Sheet of the Parent Company December 31, 2022 Prepared by: Joincare Pharmaceutical Group Industry Co., Ltd. Unit: Yuan Currency: RMB Item Note December 31, 2022 December 31, 2021 Current assets: Cash and bank balances 3,148,933,185.29 1,370,906,734.13 Financial assets held for trading Notes receivable 249,617,024.89 374,296,302.21 Accounts receivable 291,630,857.74 535,543,070.24 Receivable financing Prepayments 542,966,676.99 201,605,530.55 Other receivables 785,307,024.78 1,136,237,811.25 In which: Interest receivable Dividends receivable 544,999,500.00 814,041,000.00 Inventories 63,656,837.97 Contract assets Assets held-for-sale Non-current assets due within one year 54,048,611.11 Other current assets 9,379,100.23 Total current assets 5,136,160,218.77 3,627,968,548.61 Non-current assets: Debt investment Other debt investment Long-term receivables Long-term equity investment 3,524,184,512.63 3,530,939,152.29 Other equity instrument investment 141,562,064.27 372,609,966.35 Other non-current financial assets Investment properties 6,191,475.43 6,191,475.43 Fixed assets 46,410,672.12 45,139,232.27 Construction in progress 15,330,867.65 7,890,737.14 Productive biological assets Oil and gas assets Right-of-use assets 7,570,096.21 12,470,703.77 Intangible assets 20,154,211.97 15,316,963.24 Development cost 92,797,615.87 21,304,063.68 Goodwill Long-term prepaid expenses 552,795.74 900,737.50 Deferred tax assets 88,792,276.83 134,711,371.96 Other non-current assets 815,024,705.98 54,866,150.94 Total non-current assets 4,758,571,294.70 4,202,340,554.57 Total assets 9,894,731,513.47 7,830,309,103.18 Current liabilities: Short-term loans 100,091,666.67 450,436,811.38 Financial liabilities held for trading Notes payable 924,199,480.81 358,526,972.01 Accounts payable 257,832,649.19 461,763,867.32 Receipts in advance Contract liabilities 53,648,681.36 31,637,971.91 Employee benefits payable 139,895,738.09 95,624,280.17 Taxes payable 10,549,309.54 17,190,533.60 Other payables 1,303,649,356.48 810,207,330.35 157 Joincare Pharmaceutical Group Annual Report 2022 In which: Interests payable Dividends payable Liabilities held-for-sale Non-current liabilities due within one 47,152,440.47 44,954,632.42 year Other current liabilities 3,007,795.91 2,140,860.88 Total current liabilities 2,840,027,118.52 2,272,483,260.04 Non-current liabilities: Long-term loans 1,154,000,000.00 160,000,000.00 Bonds payable Lease liabilities 3,729,020.22 7,683,561.03 Long-term payables Long-term payroll payable Estimated liabilities Deferred income 20,534,000.00 40,796,000.00 Deferred tax liabilities 997,675.94 29,371,338.01 Other non-current liabilities Total non-current liabilities 1,179,260,696.16 237,850,899.04 Total liabilities 4,019,287,814.68 2,510,334,159.08 Owner's equity (or shareholder's equity): Paid-in capital 1,929,189,374.00 1,907,727,908.00 Other equity instruments In which: Preferred shares Perpetual debts Capital reserve 1,678,414,507.96 1,605,482,128.64 Less: Treasury shares 347,176,561.29 222,644,454.50 Other comprehensive income 726,576.72 77,015,953.08 Special reserve Surplus reserve 646,164,633.12 552,219,230.70 Undistributed profits 1,968,125,168.28 1,400,174,178.18 Total owner's equity (or shareholder's 5,875,443,698.79 5,319,974,944.10 equity) Total liabilities and owner's equity 9,894,731,513.47 7,830,309,103.18 (or shareholder's equity) Person-in-charge of the Company: Person-in-charge of the Company’s Person-in-charge of the accounting Zhu Baoguo accounting work: Qiu Qingfeng department: Qiu Qingfeng 158 Joincare Pharmaceutical Group Annual Report 2022 Consolidated Income Statement From January to December, 2022 Unit: Yuan Currency: RMB Item Note 2022 2021 I. Total revenues V.43 17,142,753,068.82 15,903,688,266.59 In which: Operating revenues 17,142,753,068.82 15,903,688,266.59 II. Total operating costs 13,784,938,368.95 13,169,412,648.95 In which: Operating costs V.43 6,252,265,308.40 5,716,293,887.58 Operating tax and surcharges V.44 199,746,357.56 182,816,650.02 Selling expenses V.45 4,950,802,456.16 5,026,812,145.41 Administrative expenses V.46 992,483,591.51 939,253,444.33 R&D expenses V.47 1,742,088,079.94 1,397,131,273.33 Financial expenses V.48 -352,447,424.62 -92,894,751.72 In which: Interest expenses 139,016,104.44 90,278,042.69 Interest income 395,476,309.66 191,964,051.82 Add: Other income V.49 289,868,006.44 247,346,934.96 Income from investments (loss is V.50 55,973,114.29 71,881,264.65 indicated by “-”) In which: Income from investments 70,577,657.04 10,281,021.59 in associates and joint ventures Gains from derecognition of financial assets at amortized cost Gains from net exposure hedges (loss is indicated by “-”) Gains from changes in fair values V.51 -76,262,989.83 -23,506,126.09 (loss is indicated by “-”) Losses of credit impairment (loss is V.52 -4,123,743.37 -8,024,112.20 indicated by “-”) Impairment loss of assets (loss is V.53 -142,627,936.44 -62,950,978.72 indicated by “-”) Gains from disposal of assets (loss V.54 -705,357.30 24,044,186.55 is indicated by “-”) III. Operating profit (loss is indicated by 3,479,935,793.66 2,983,066,786.79 “-”) Add: Non-operating income V.55 8,229,847.57 8,641,830.86 Less: Non-operating expenses V.56 32,060,686.06 39,379,273.69 IV. Total profit (loss is indicated by “-”) 3,456,104,955.17 2,952,329,343.96 Less: Income tax expenses V.57 562,008,858.69 339,480,305.29 V. Net profit (loss is indicated by “-”) 2,894,096,096.48 2,612,849,038.67 (I) Classified by business continuity 1. Net profit from ongoing operation (loss 2,894,096,096.48 2,612,849,038.67 is indicated by “-”) 2. Net profit from discontinuing operation (loss is indicated by “-”) (II) Classified by ownership 1.Net profit attributable to shareholders of the parent company (loss is indicated by 1,502,595,840.48 1,328,499,432.05 “-”) 2.Profit and loss of minority shareholders 1,391,500,256.00 1,284,349,606.62 (loss is indicated by “-”) VI. Other comprehensive income, net of tax 74,606,735.39 -177,686,201.25 159 Joincare Pharmaceutical Group Annual Report 2022 (I) Other comprehensive income attributable to owners of the parent -683,072.44 -110,913,013.31 company, net of tax 1. Other comprehensive income that cannot -85,577,350.31 -78,059,481.21 be reclassified into profit or loss (1) Changes from remeasurement of defined benefit plans (2) Other comprehensive income that cannot be reclassified into profit or loss 2,116,352.61 6,658,847.65 under the equity method (3) Changes in fair value of investments in -87,693,702.91 -84,718,328.85 other equity instruments (4) Changes in fair value of the enterprise's own credit risks 2. Other comprehensive income that will be 84,894,277.87 -32,853,532.10 reclassified into profit or loss (1) Other comprehensive income that can be reclassified into profit or loss under the 236,421.59 -13,599.80 equity method (2) Changes in fair value of other debt investments (3) Amount of financial assets reclassified into other comprehensive income (4) Provision for credit impairment of other debt investments (5) Reserve for cash flow hedges (6) Exchange differences on translation of financial statements denominated in foreign 84,657,856.28 -32,839,932.30 currencies (7) Others (II) Other comprehensive income attributable to minority shareholders, net of 75,289,807.82 -66,773,187.94 tax VII. Total comprehensive income 2,968,702,831.87 2,435,162,837.42 (I) Total comprehensive income attributable 1,501,912,768.04 1,217,586,418.74 to owners of the parent company (II) Total comprehensive income 1,466,790,063.82 1,217,576,418.68 attributable to minority shareholders VIII. Earnings per share: (I) Basic earnings per share (RMB/share) 0.7933 0.6864 (II) Diluted earnings per share (RMB/share) 0.7921 0.6858 Person-in-charge of the Company: Person-in-charge of the Company’s Person-in-charge of the accounting Zhu Baoguo accounting work: Qiu Qingfeng department: Qiu Qingfeng 160 Joincare Pharmaceutical Group Annual Report 2022 Income Statement of the Parent Company From January to December, 2022 Unit: Yuan Currency: RMB Item Note 2022 2021 I. Operating revenues 2,373,887,564.78 2,021,173,825.62 Less: Operating costs 1,612,899,011.80 1,356,825,036.11 Operating tax and surcharges 14,203,470.53 12,392,762.31 Selling expenses 645,474,076.69 509,217,536.91 Administrative expenses 195,475,435.39 152,344,869.22 R&D expenses 66,705,404.14 99,273,556.14 Financial expenses -38,112,993.67 -18,244,358.04 In which: Interest expenses 25,257,639.51 4,032,165.84 Interest income 70,313,743.55 22,710,793.68 Add: Other income 23,934,298.39 1,551,111.38 Income from investments (loss is indicated by “-”) 991,369,051.76 1,293,747,303.58 In which: Income from investments in associates and joint 1,326,243.55 -2,005,822.14 ventures Gains from derecognition of financial assets at amortized cost Gains from net exposure hedges (loss is indicated by “-”) Gains from changes in fair values (loss is indicated by “-”) Losses of credit impairment (loss is indicated by “-”) 1,856,898.77 -203,993.20 Impairment loss of assets (loss is indicated by “-”) -154,249.81 -41,007.68 Gains from disposal of assets (loss is indicated by “-”) II. Operating profit (loss is indicated by “-”) 894,249,159.01 1,204,417,837.05 Add: Non-operating income 232,093.51 75,665.33 Less: Non-operating expenses 1,660,096.56 13,762,938.68 III. Total profit (loss is indicated by “-”) 892,821,155.96 1,190,730,563.70 Less: Income tax expenses 43,089,198.01 -58,066,575.23 IV. Net profit (loss is indicated by “-”) 849,731,957.95 1,248,797,138.93 (1) Net profit from ongoing operation (loss is indicated by “-”) 849,731,957.95 1,248,797,138.93 (II) Net profit from discontinuing operation (loss is indicated by “-”) V. Other comprehensive income, net of tax -76,289,376.36 -33,565,798.21 (I) Other comprehensive income not to be reclassified into -76,289,376.36 -33,565,798.21 profit and loss 1. Changes from remeasurement of defined benefit plans 2. Other comprehensive income that cannot be reclassified into profit or loss under the equity method 3. Changes in fair value of investments in other equity -76,289,376.36 -33,565,798.21 instruments 4. Changes in fair value of the enterprise's own credit risks (II). Other comprehensive income that will be reclassified into profit and loss 1. Other comprehensive income that can be reclassified into profit or loss under the equity method 2. Changes in fair value of other debt investments (3) Amount of financial assets reclassified into other comprehensive income (4) Provision for credit impairment of other debt investments (5) Reserve for cash flow hedges (6) Exchange differences on translation of financial statements denominated in foreign currencies 161 Joincare Pharmaceutical Group Annual Report 2022 (7) Others VI. Total comprehensive income 773,442,581.59 1,215,231,340.72 VII. Earnings per share: (1) Basic earnings per share (RMB/share) (2) Diluted earnings per share (RMB/share) Person-in-charge of the Company: Person-in-charge of the Company’s Person-in-charge of the accounting Zhu Baoguo accounting work: Qiu Qingfeng department: Qiu Qingfeng 162 Joincare Pharmaceutical Group Annual Report 2022 Consolidated Cash Flow Statement From January to December, 2022 Unit: Yuan Currency: RMB Item Note 2022 2021 I. Cash flow from operating activities: Cash received from sales of goods and rendering of services 18,615,546,255.83 16,302,075,867.93 Tax refunds received 247,896,245.67 142,987,224.70 Other cash received related to operating activities V.58 683,645,734.39 545,037,436.64 Subtotal of cash inflow from operating activities 19,547,088,235.89 16,990,100,529.27 Cash paid for goods and services 5,728,697,037.48 4,536,979,552.07 Cash paid to and on behalf of employees 2,260,612,483.52 1,950,726,146.40 Payments of all types of taxes 1,668,389,310.43 1,653,421,224.28 Other cash paid related to operating activities V.58 5,911,684,265.17 6,285,884,561.28 Subtotal of cash outflow in operating activities 15,569,383,096.60 14,427,011,484.03 Net cash flow from operating activities 3,977,705,139.29 2,563,089,045.24 II. Cash flow from investing activities: Cash received from disposal of investment 270,997,751.54 155,208,882.44 Cash received from returns on investments 144,358,825.55 114,833,282.84 Net cash received from disposal of fixed assets, intangible 3,096,825.59 9,404,128.73 assets and other long-term assets Net cash received from disposal of subsidiaries and other 3,311,220.53 business units Other cash received related to investing activities V.58 13,563,902.59 113,574,087.21 Subtotal of cash inflow from investing activities 432,017,305.27 396,331,601.75 Cash paid for purchase and construction of fixed assets, 1,147,832,255.23 1,521,419,292.51 intangible assets and other long-term assets Cash paid for investment 416,183,775.89 786,000,000.00 Net cash paid for acquisition of subsidiaries and other business units Other cash paid related to investing activities V.58 1,120,168,462.77 53,070,040.41 Subtotal of cash outflow in investing activities 2,684,184,493.89 2,360,489,332.92 Net cash flow from investing activities -2,252,167,188.62 -1,964,157,731.17 III. Cash flow from financing activities: Cash received from capital contribution 746,673,937.95 609,358,382.32 In which: Cash received from investment by minority 45,595,924.92 526,782,825.73 interests of subsidiaries Cash received from borrowings 5,339,517,086.47 3,534,880,943.19 Other cash received related to financing activities V.58 381,066,270.61 37,852,177.42 Subtotal of cash inflow from financing activities 6,467,257,295.03 4,182,091,502.93 Cash repayments of amounts borrowed 3,718,797,777.63 2,593,581,286.53 Cash payments for interest expenses and distribution of 1,350,994,668.54 1,271,374,383.55 dividends or profits In which: Dividend paid to minority interests of subsidiaries 961,951,199.52 888,900,577.12 Other cash payments related to financing activities V.58 831,342,189.06 1,292,040,186.29 Subtotal of cash outflow in financing activities 5,901,134,635.23 5,156,995,856.37 Net cash flow from financing activities 566,122,659.80 -974,904,353.44 IV. Effect of foreign exchange rate changes on cash 189,286,934.75 -49,290,130.94 V. Net increase in cash and cash equivalents 2,480,947,545.22 -425,263,170.31 Add: Opening balance of cash and cash equivalents 11,697,518,141.18 12,122,781,311.49 VI. Closing balance of cash and cash equivalents 14,178,465,686.40 11,697,518,141.18 Person-in-charge of the Company: Person-in-charge of the Company’s Person-in-charge of the accounting Zhu Baoguo accounting work: Qiu Qingfeng department: Qiu Qingfeng 163 Joincare Pharmaceutical Group Annual Report 2022 Cash Flow Statement of Parent Company From January to December, 2022 Unit: Yuan Currency: RMB Item Note 2022 2021 I. Cash flow from operating activities: Cash received from sales of goods and 3,146,093,806.02 2,029,373,201.42 rendering of services Tax refunds 82,831.63 Other cash received related to operating 2,960,613,006.52 606,516,829.33 activities Subtotal of cash inflow from operating 6,106,789,644.17 2,635,890,030.75 activities Cash paid for goods and services 1,901,562,593.41 983,814,721.63 Cash paid to and on behalf of employees 246,881,656.93 181,261,857.67 Payments of all types of taxes 103,904,304.93 107,046,894.42 Other cash paid related to operating 3,109,052,257.96 1,062,779,580.04 activities Subtotal of cash outflow in operating 5,361,400,813.23 2,334,903,053.76 activities Net cash flow from operating activities 745,388,830.94 300,986,976.99 II. Cash flow from investing activities: Cash received from disposal of 270,997,751.54 68,268,656.05 investment Cash received from returns on 1,276,079,344.80 632,000,814.98 investments Net cash received from disposal of fixed assets, intangible assets and other long- 21,000.00 81,400.00 term assets Net cash received from disposal of subsidiaries and other business units Other cash received related to investing 158,470.77 101,013,650.67 activities Subtotal of cash inflow from investing 1,547,256,567.11 801,364,521.70 activities Cash paid for purchase and construction of fixed assets, intangible assets and other 11,869,023.45 8,127,874.33 long-term assets Cash paid for investment 10,000,000.00 319,037,191.00 Net cash paid for acquisition of subsidiaries and other business units Other cash paid related to investing 1,084,392,104.38 50,000,000.00 activities Subtotal of cash outflow in investing 1,106,261,127.83 377,165,065.33 activities Net cash flow from investing activities 440,995,439.28 424,199,456.37 III. Cash flow from financing activities: Cash received from capital contribution 701,078,013.03 82,575,556.59 Cash received from borrowings 1,500,000,000.00 650,000,000.00 Other cash received related to financing 36,583,025.57 activities Subtotal of cash inflow from financing 2,201,078,013.03 769,158,582.16 activities Cash repayments of amounts borrowed 854,000,000.00 500,000,000.00 164 Joincare Pharmaceutical Group Annual Report 2022 Cash payments for interest expenses and 299,984,479.95 292,289,892.43 distribution of dividends or profits Other cash payments related to financing 740,517,545.44 701,265,930.75 activities Subtotal of cash outflow in financing 1,894,502,025.39 1,493,555,823.18 activities Net cash flow from financing activities 306,575,987.64 -724,397,241.02 IV. Effect of foreign exchange rate -5,804,971.77 296,539.18 changes on cash V. Net increase in cash and cash 1,487,155,286.09 1,085,731.52 equivalents Add: Opening balance of cash and cash 1,370,906,734.13 1,369,821,002.61 equivalents VI. Closing balance of cash and cash 2,858,062,020.22 1,370,906,734.13 equivalents Person-in-charge of the Company: Person-in-charge of the Company’s Person-in-charge of the accounting Zhu Baoguo accounting work: Qiu Qingfeng department: Qiu Qingfeng 165 Joincare Pharmaceutical Group Annual Report 2022 Consolidated Statement of Changes in Owner's Equity From January to December, 2022 Unit: Yuan Currency: RMB 2022 Owner's equity attributable to the parent company Item Minority Total owner's Other equity instruments Other General shareholder's equity equity Less: Treasury Special Paid-up capital Capital reserve comprehensive Surplus reserve risk Undistributed profits Subtotal Preferred Perpetual shares reserve Others income provision share debts I. Balance at the end of previous 1,907,727,908.00 2,265,357,311.92 222,644,454.50 5,387,545.97 640,821,179.08 7,223,644,166.22 11,820,293,656.69 8,359,317,322.63 20,179,610,979.32 year Add: Change of accounting policies Correction to errors of the previous period Business combination involving enterprises under common control Others II. Balance in 1,907,727,908.00 2,265,357,311.92 222,644,454.50 5,387,545.97 640,821,179.08 7,223,644,166.22 11,820,293,656.69 8,359,317,322.63 20,179,610,979.32 beginning of year III. Increase and decrease of the 21,461,466.00 78,335,904.07 124,532,106.79 -683,072.44 93,945,402.42 1,232,999,160.60 1,301,526,753.86 539,089,964.49 1,840,616,718.35 current year (enter “-” for decrease) (I) Total comprehensive -683,072.44 1,502,595,840.48 1,501,912,768.04 1,466,790,063.82 2,968,702,831.87 income (II). Capital contribution or 21,461,466.00 72,932,379.32 124,532,106.79 -30,138,261.47 -9,149,286.66 -39,287,548.13 reduction from shareholders 1. Capital contribution from 72,421,134.00 612,201,980.48 724,513,822.62 -39,890,708.14 22,487,013.47 -17,403,694.67 shareholders 2. Capitals invested by other equity instrument holders 3. Amount of share-based 9,752,446.67 9,752,446.67 9,752,446.67 payment included in owner's equity 4. Others -50,959,668.00 -549,022,047.83 -599,981,715.83 -31,636,300.13 -31,636,300.13 166 Joincare Pharmaceutical Group Annual Report 2022 (III). Profit 84,973,195.80 -362,530,827.45 -277,557,631.65 -967,251,289.90 -1,244,808,921.55 distribution 1. Accrual of 84,973,195.80 -84,973,195.80 surplus reserve 2. Accrual of general risk provision 3. Amount distributed to -277,557,631.65 -277,557,631.65 -967,251,289.90 -1,244,808,921.55 owners (or shareholders) 4. Others (IV) Internal carrying forward of 8,972,206.62 92,934,147.57 101,906,354.19 15,012,358.44 116,918,712.63 owner's equity 1. Capital reserve transferred to increase capital (or share capital) 2. Surplus reserve transferred to increase capital (or share capital) 3. Surplus reserve compensating losses 4. Retained earnings carried over from changes in the defined benefit plan 5. Retained earnings carried over from other 8,972,206.62 92,934,147.57 101,906,354.19 15,012,358.44 116,918,712.63 comprehensive income 6. Others (V) . Special reserve 1. Accrual of the current year 2. Amount utilized in the current period (VI) . Others 5,403,524.75 5,403,524.75 33,688,118.79 39,091,643.54 IV. Balance at end 1,929,189,374.00 2,343,693,215.99 347,176,561.29 4,704,473.53 734,766,581.50 8,456,643,326.82 13,121,820,410.55 8,898,407,287.12 22,020,227,697.67 of year 167 Joincare Pharmaceutical Group Annual Report 2022 2021 Owner's equity attributable to the parent company Item Other equity instruments Other General Minority Less: Treasury Special Undistributed Total owner's equity Paid-up capital Preferred Perpetual Capital reserve comprehensive Surplus reserve risk Subtotal shareholder's equity Others shares reserve profits share debts income provision I. Balance at the end of previous 1,952,780,764.00 2,533,288,674.28 253,637,154.50 116,300,559.28 515,941,465.19 6,231,451,582.26 11,096,125,890.51 8,140,772,186.49 19,236,898,077.00 year Add: Change of accounting policies Correction to errors of the previous period Business combination involving enterprises under common control Others II. Balance in 1,952,780,764.00 2,533,288,674.28 253,637,154.50 116,300,559.28 515,941,465.19 6,231,451,582.26 11,096,125,890.51 8,140,772,186.49 19,236,898,077.00 beginning of year III. Increase and decrease of the -45,052,856.00 -267,931,362.36 -30,992,700.00 -110,913,013.31 124,879,713.89 992,192,583.96 724,167,766.18 218,545,136.13 942,712,902.32 current year (enter “-” for decrease) (I). Total comprehensive -110,913,013.31 1,328,499,432.05 1,217,586,418.74 1,217,576,418.68 2,435,162,837.42 income (II). Capital contribution or -45,052,856.00 -570,478,635.27 -30,992,700.00 -584,538,791.27 -21,931,055.41 -606,469,846.68 reduction from shareholders 1. Capital contribution from 10,082,440.00 72,493,116.59 699,900,526.87 -617,324,970.28 437,967,405.33 -179,357,564.95 shareholders 2. Capitals invested by other equity instrument holders 3. Amount of share- based payment 1,793,479.01 1,793,479.01 1,793,479.01 included in owner's equity 4. Others -55,135,296.00 -644,765,230.87 -730,893,226.87 30,992,700.00 -459,898,460.74 -428,905,760.74 (III). Profit 124,879,713.89 -413,555,101.94 -288,675,388.05 -887,433,971.08 -1,176,109,359.13 distribution 1. Accrual of 124,879,713.89 -124,879,713.89 surplus reserve 168 Joincare Pharmaceutical Group Annual Report 2022 2. Accrual of general risk provision 3. Amount distributed to -288,675,388.05 -288,675,388.05 -887,433,971.08 -1,176,109,359.13 owners (or shareholders) 4. Others (IV) . Internal carrying forward of 77,248,253.85 77,248,253.85 94,678,535.62 171,926,789.47 owner's equity 1. Capital reserve transferred to increase capital (or share capital) 2. Surplus reserve transferred to increase capital (or share capital) 3. Surplus reserve compensating losses 4. Retained earnings carried over from changes in the defined benefit plan 5. Retained earnings carried over from other 77,248,253.85 77,248,253.85 94,678,535.62 171,926,789.47 comprehensive income 6. Others (V) . Special reserve 1. Accrual of the current year 2. Amount utilized in the current period (VI) . Others 302,547,272.91 302,547,272.91 -184,344,791.68 118,202,481.23 IV. Balance at end 1,907,727,908.00 2,265,357,311.92 222,644,454.50 5,387,545.97 640,821,179.08 7,223,644,166.22 11,820,293,656.69 8,359,317,322.63 20,179,610,979.32 of year Person-in-charge of the Company: Person-in-charge of the Company’s accounting work: Person-in-charge of the accounting department: Zhu Baoguo Qiu Qingfeng Qiu Qingfeng 169 Joincare Pharmaceutical Group Annual Report 2022 Statement of Changes in Owner's Equity of the Parent Company From January to December, 2022 Unit: Yuan Currency: RMB 2022 Other equity instruments Other Item Less: Treasury Special Undistributed Total owner's Paid-up capital Preferre Perpetual Capital reserve comprehensive Surplus reserve Others shares reserve profits equity d share debts income I. Balance at the end of previous year 1,907,727,908.00 1,605,482,128.64 222,644,454.50 77,015,953.08 552,219,230.70 1,400,174,178.18 5,319,974,944.10 Add: Change of accounting policies Correction to errors of the previous period Others II. Balance in beginning of year 1,907,727,908.00 1,605,482,128.64 222,644,454.50 77,015,953.080 552,219,230.70 1,400,174,178.18 5,319,974,944.10 III. Increase and decrease of the current year 21,461,466.00 72,932,379.32 124,532,106.79 -76,289,376.362 93,945,402.42 567,950,990.10 555,468,754.69 (enter “-” for decrease) (I). Total comprehensive income -76,289,376.362 849,731,957.95 773,442,581.59 (II) Capital contribution or reduction from 21,461,466.00 72,932,379.32 124,532,106.79 -30,138,261.47 shareholders 1. Capital contribution from shareholders 72,421,134.00 612,201,980.48 724,513,822.62 -39,890,708.14 2. Capitals invested by other equity instrument holders 3. Amount of share-based payment included in 9,752,446.67 9,752,446.67 owner's equity 4. Others -50,959,668.00 -549,022,047.83 -599,981,715.83 (III). Profit distribution 84,973,195.80 -362,530,827.45 -277,557,631.65 1. Accrual of surplus reserve 84,973,195.80 -84,973,195.80 2. Amount distributed to owners (or shareholders) -277,557,631.65 -277,557,631.65 3. Others (IV) . Internal carrying forward of owner's 8,972,206.62 80,749,859.60 89,722,066.22 equity 1. Capital reserve transferred to increase capital (or share capital) 2. Surplus reserve transferred to increase capital (or share capital) 3. Surplus reserve compensating losses 4. Retained earnings carried over from changes in the defined benefit plan 5. Retained earnings carried over from other 8,972,206.62 80,749,859.60 89,722,066.22 comprehensive income 6. Others (V) . Special reserve 1. Accrual of the current year 2. Amount utilized in the current period (VI) . Others IV. Balance at end of year 1,929,189,374.00 1,678,414,507.96 347,176,561.29 726,576.72 646,164,633.12 1,968,125,168.28 5,875,443,698.79 170 Joincare Pharmaceutical Group Annual Report 2022 2021 Other equity instruments Other Item Less: Treasury Special Undistributed Paid-up capital Preferred Perpetual Capital reserve comprehensive Surplus reserve Total owner's equity Others shares reserve profits share debts income I. Balance at the end of previous year 1,952,780,764.00 2,169,622,381.22 253,637,154.50 110,581,751.29 427,339,516.81 564,932,141.19 4,971,619,400.01 Add: Change of accounting policies Correction to errors of the previous period Others II. Opening balance of the current year 1,952,780,764.00 2,169,622,381.22 253,637,154.50 110,581,751.29 427,339,516.81 564,932,141.19 4,971,619,400.01 III. Increase and decrease of the current year -45,052,856.00 -564,140,252.58 -30,992,700.00 -33,565,798.21 124,879,713.89 835,242,036.99 348,355,544.09 (enter “-” for decrease) (I). Total comprehensive income -33,565,798.21 1,248,797,138.93 1,215,231,340.72 (II). Capital contribution or reduction from -45,052,856.00 -570,478,635.27 -30,992,700.00 -584,538,791.27 shareholders 1. Capital contribution from shareholders 10,082,440.00 72,493,116.59 699,900,526.87 -617,324,970.28 2. Capitals invested by other equity instrument holders 3. Amount of share-based payment included in 1,793,479.01 1,793,479.01 owner's equity 4. Others -55,135,296.00 -644,765,230.87 -730,893,226.87 30,992,700.00 (III). Profit distribution 124,879,713.89 -413,555,101.94 -288,675,388.05 1. Accrual of surplus reserve 124,879,713.89 -124,879,713.89 2. Amount distributed to owners (or -288,675,388.05 -288,675,388.05 shareholders) 3. Others (IV) . Internal carrying forward of owner's equity 1. Capital reserve transferred to increase capital (or share capital) 2. Surplus reserve transferred to increase capital (or share capital) 3. Surplus reserve compensating losses 4. Retained earnings carried over from changes in the defined benefit plan 5. Retained earnings carried over from other comprehensive income 6. Others (V) Special reserve 1. Accrual of the current year 2. Amount utilized in the current period (VI) Others 6,338,382.69 6,338,382.69 IV. Balance at end of year 1,907,727,908.00 1,605,482,128.64 222,644,454.50 77,015,953.08 552,219,230.70 1,400,174,178.18 5,319,974,944.10 Person-in-charge of the Company: Zhu Baoguo Person-in-charge of the Company’s accounting work: Person-in-charge of the accounting department: Qiu Qingfeng Qiu Qingfeng 171 Joincare Pharmaceutical Group Annual Report 2022 Joincare Pharmaceutical Group Industry Co., Ltd Notes to the financial statements (All amounts in RMB Yuan unless otherwise stated) I. Company Profile 1. Company Overview The Company is formerly known as Shenzhen Aimier Food Co., Ltd. (深圳爱迷尔食品有限公司), was a Sino-foreign joint venture officially established on 18 December 1992 with the approval from Shenzhen Administration for Industry and Commerce. On 24 November 1999, the Company was reorganized as a joint stock limited company. On 6 February 2001, the Company was approved by the China Securities Regulatory Commission to issue domestically listed shares (A shares) to the public. On 8 June 2001, shares of the Company were listed and traded on Shanghai Stock Exchange. As of 31 December 2022, the total share capital of the Company was RMB1,929,189,374 for a total number of shares of 1,929,189,374 shares. The controlling shareholder of the Company is Shenzhen Baiyeyuan Investment Co., Ltd. (深圳市百业源投资有限公司), and the ultimate controlling party is Zhu Baoguo (朱 保国). The Company is engaged in the pharmaceutical industry. The Company and its subsidiaries primarily engaged in the R&D, production and sale of pharmaceutical products and healthcare products, which covered drug preparation products, active pharmaceutical ingredients (“APIs”) and intermediates, diagnostic reagents and equipment as well as healthcare products. 2. Scope of consolidated financial statements The information of subsidiaries included in the scope of consolidation for the year ended 31 December 2022 refer to Note VII “Equity in other entities” and the information of the changes in scope of consolidation during the period refer to Note VI “Changes in scope of consolidation”. II. Basis of Preparation for the Financial Statements The financial statements have been prepared in accordance with the Accounting Standards for Business Enterprises issued by the MOF and its application guidance, interpretations and the other related provisions (collectively, the “Accounting Standards for Business Enterprises”). In addition, the Company also discloses relevant financial information in accordance with the Information Disclosure and Presentation Rules for Companies Offering Securities to the Public No. 15 – General Provisions on Financial Reporting (2014 Revision) issued by the China Securities Regulatory Commission. The financial statements have been prepared on the going-concern basis. The Company's accounting is measured on an accrual basis. Except for certain financial instruments, the financial statements are generally measured at historical cost. Non-current assets held for sale are stated at the lower of fair value less estimated selling costs and their original carrying amount if they qualify as held for sale. In case of asset impairment, the Company shall make provisions for impairment in accordance with applicable provisions. III. Significant Accounting Policies and Accounting Estimates 172 Joincare Pharmaceutical Group Annual Report 2022 The Company determines the depreciation of fixed assets, amortisation of intangible assets, capitalisation condition of R&D expenses and revenue recognition policies on the basis of its production and operation characteristics. Details of accounting policies are set out in Note III.16, Note III.20, Note III.21 and Note III.28. 1. Statement of compliance with the Accounting Standards for Business Enterprises The financial statements comply with the Accounting Standards for Business Enterprises, which gave a true and complete view of the consolidated and the Company's financial positions as at 31 December 2022, and the consolidated and the Company’s operating results and the consolidated and the Company’s cash flows and other relevant information for the year ended 31 December 2022. 2. Accounting period The fiscal year of the Company is from 1 January to 31 December in each calendar year. 3. Operating cycle The Company’s operating cycle is 12 months. 4. Functional currency The functional currency of the Company and its domestic subsidiaries is Renminbi (“RMB”). Overseas subsidiaries of the Company usually recognise HK dollar, Macau dollar and US dollar as their functional currencies according to the primary economic environment of which these subsidiaries operate. The Company prepares its financial statements in RMB. 5. Accounting treatment for business combinations involving enterprises under common control and business combinations involving enterprises not under common control (1) Business combinations involving enterprises under common control For the business combination involving entities under common control, the assets acquired and liabilities assumed are measured based on their carrying amounts in the consolidated financial statements of the ultimate controlling party as at the combination date. The difference between the carrying amount of the consideration paid for the combination and the net assets acquired is adjusted against share premium in the capital reserve, with any excess adjusted against retained earnings. Business combination involving enterprises under common control and achieved in a number of transactions In the separate financial statements, the initial investment cost will be recognised at the carrying amount of the Company's share in the combined party's net assets in the consolidated financial statements of the ultimate controlling party on the date of combination. The difference between the initial investment cost and the sum of the carrying amount of the investment held and the carrying amount of consideration paid for the combination at the combination date is adjusted against share premium in the capital reserve, with any excess adjusted against retained earnings. In the consolidated financial statements, the assets acquired and liabilities assumed are measured based on their carrying amounts in the consolidated financial statements of the ultimate controlling party as at the combination date. The difference between sum of the carrying amount of the investment held and the carrying amount of the consideration paid for the combination and the carrying amount of the net assets acquired is adjusted against share premium in the capital reserve, with any excess adjusted against retained earnings. For long-term equity investment held before the control over the combined party is obtained, profit or loss, other comprehensive income and other changes to equity interest attributable to the owners recognised from the later of the acquisition of the original equity interest and the date when the combing party and the combined party are placed under common control until the date of combination shall be offset against retained profit at the beginning of the period of the comparative financial statements or profit or loss of the period respectively. (2) Business combinations involving enterprises not under common control 173 Joincare Pharmaceutical Group Annual Report 2022 For the business combinations involving enterprises not under common control, the combination cost shall be the fair value of the assets transferred, liabilities incurred or assumed, and equity securities issued by the acquirer for acquisition of control in the acquiree on the acquisition date. The assets, liabilities and contingent liabilities acquired or assumed on the date of acquisition are recognised at fair value. Where the combination cost exceeds the fair value of the acquiree's identifiable net assets in the business combination, the difference is recognised as goodwill and is subsequently measured at cost less accumulated impairment provisions. Where the combination cost is less than the fair value of the acquiree's identifiable net assets in the business combination, the difference shall be included in profit or loss for the period after review. Business combination involving enterprises not under common control and achieved in a number of transactions In the separate financial statements, the initial cost of the investment is the sum of the carrying amount of the acquiree's equity investment held before the acquisition date and the additional investment cost on the acquisition date. In respect of the equity investment held prior to the acquisition date, other comprehensive income will not be recognised using equity method on the acquisition date, and such investment will be accounted for on the same accounting treatment as direct disposal of relevant asset or liability by the investee at the time of disposal. Shareholder's equity recognised due to the changes of other shareholder's equity other than the changes of net loss and profit, other comprehensive income and profit distribution shall be transferred to profit or loss for current period when disposed. If the equity investment held prior to the acquisition date is measured at fair value, the cumulative changes in fair value recognised in other comprehensive income shall be transferred to retained earnings when accounted for using cost method. In the consolidated financial statements, the combination cost is the sum of consideration paid on the acquisition date and fair value of the acquiree's equity held prior to the acquisition date. The equity of the acquirees held before the acquisition date is re-measured at the fair value of the equity on the acquisition date and the differences between the fair value and the carrying amount are recognised in the income for the current period; in respect of any other comprehensive income attributable to the equity interest in the acquiree held prior to the acquisition date and any changes of other shareholder's equity shall be transferred to investment profit or loss for current period on the acquisition date, except for the other comprehensive income incurred due to the changes arising from remeasuring net assets or net liabilities of defined benefit plan attributable to the acquiree. (3) Transaction fees attribution during the combination The intermediary and other relevant administrative expenses such as audit, legal and valuation advisory for business combinations are recognised in profit or loss when incurred. Transaction costs of equity or debt securities issued as the considerations of business combination are included in the initial recognition amounts. 6. Preparation of consolidated financial statements (1) Scope of consolidation The scope of consolidated financial statements is determined based on control. Control means the Company has exposures or rights to variable returns from its involvement with the investee and the ability to affect those returns through power over such investee. Subsidiaries are the entities controlled by the Company (including enterprises, a dividable part of investees and structured entities). (2) Method for preparation of the consolidated financial statements The consolidated financial statements are based on the financial statements of the Company and its subsidiaries, and are prepared by the Company in accordance with other relevant information. In preparing the consolidation financial statements, the Company and its subsidiaries are required to apply consistent accounting policy and accounting period, intra-group transactions and balances shall be offset. A subsidiary or a business acquired through a business combination involving entities under common control 174 Joincare Pharmaceutical Group Annual Report 2022 in the reporting period shall be included in the scope of the consolidation of the Company from the date when it is under control of the ultimate controlling party, and then its operating results and cash flows will be included in the consolidated income statement and the consolidated cash flow statement, respectively. For a subsidiary or a business acquired through a business combination involving entities not under common control in the reporting period, its income, expenses and profits are included in the consolidated income statement, and its cash flows are included in the consolidated cash flow statement from the acquisition date to the end of the reporting date. The shareholders' equity of the subsidiaries that are not attributable to the Company shall be presented under shareholders' equity in the consolidated balance sheet as minority interests. The portion of net profit or loss of subsidiaries for the period attributable to minority interest is presented in the consolidated income statement under the “profit or loss of minority interest”. When the amount of loss attributable to the minority shareholders of a subsidiary exceeds the minority shareholders' portion of the opening balance of owners' equity of the subsidiary, the excess amount shall be allocated against minority interest. (3) Purchase of the minority stake in the subsidiary The difference between the long-term equity investments costs acquired by the purchase of minority interests and the share of the net assets that the subsidiaries have to continue to calculate from the date of purchase or the date of consolidation in proportion to the new shareholding ratio, and the difference between the disposal of the equity investment without losing control over its subsidiary and the disposal of the long-term equity investment corresponding to the share of the net assets of the subsidiaries from the date of purchase or the date of consolidation, shall be adjusted to the capital reserve (or share premium), if the capital reserve is not sufficient, any excess will be adjusted to retained earnings. (4) Treatment of loss of control of subsidiaries Where the Company loses its control over the original subsidiary due to the disposal of some equity investment or other reasons, the remaining equity is re-measured at its fair value on the date when the Company loses its control. The difference between the sum of the consideration acquired due to the disposal of the equity and the fair value of the remaining equity, and the Company's share in the sum of carrying value of net assets of the original subsidiary and goodwill calculated on an ongoing basis from the acquisition date based on the original shareholding proportion is recognised in the investment income for the current period when the control is lost. Other comprehensive income in relation to the original subsidiary's equity investment are transferred to profit or loss for the current period when control ceases, except for those arising from re-measuring net assets or net liabilities of defined benefit plan by the investee. (5) Treatment of disposal through several transactions until the loss of control of subsidiaries Where the Company disposes of the equity interests in the subsidiary through several transactions until it loses control, and the transaction terms, conditions and economic effects satisfy one or several of the following circumstances, such several transactions shall be deemed as a basket of transactions in accounting treatment: ① Such transactions are entered into simultaneously or upon the consideration of the mutual impacts; ② No complete commercial result will be realised without such transactions as a whole; ③ The occurrence of one transaction depends on the occurrence of at least another transaction; ④ The result of an individual transaction is not economical, but it would be economical after taken into account of other transactions in the series. In the separate financial statements, where the Company disposes of the equity investment in the subsidiary through several transactions until the loss of control, and such transactions are not regarded as “a basket of 175 Joincare Pharmaceutical Group Annual Report 2022 transactions”, the carrying amount of the long-term equity investment involving each disposal will be carried forward, with the difference between the disposal price and the carrying amount of the long-term equity investment involving the disposal being accounted into the investment incomes for the current period; where the transactions constitute “a basket of transactions”, the difference between the consideration of each disposal and the carrying amount of the long-term equity investment involving the disposal before the loss of the control, is recognised as the other comprehensive income and will be carried forward to the profit or loss for the current period when the control is lost. In the consolidated financial statements, where the Company disposes of the equity investment in the subsidiary through several transactions until the loss of control, the measurement of the remaining equity interest and the accounting treatment of the losses and gains of the disposal will be made with reference to the “Treatment of loss of control of subsidiaries” as described above. For the difference between the consideration of each disposal before the loss of the control and the carrying amount of the Company's share in the net assets involving the disposal of such subsidiary calculated on an on-going basis from the acquisition date, the treatment will be made as follows: ① In case the transactions are “a basket of transactions”, such difference is recognised as the other comprehensive income and will be carried forward to the profit or loss for the current period when the control is lost. ② In case the transactions are not “a basket of transactions”, such difference is accounted into the capital reserve (or share premium) as equity, and shall not be carried forward to the profit or loss for the current period when the control is lost. 7. Classification of joint arrangement and accounting treatment for joint operation A joint arrangement is an arrangement jointly controlled by two or more parties. The Company's joint arrangement is classified into the joint operation and the joint venture. (1) Joint operation A joint operation is a joint arrangement whereby the Company have rights and obligations to the relevant assets and liabilities. The Company recognises the following items in relation to its interest in a joint operation, and makes corresponding accounting treatment in accordance with relevant accounting standards: A. The solely-held assets, and the share of any assets held jointly; B. The solely-assumed liabilities, and its share of any liabilities incurred jointly; C. Its revenue from the sale of its share of the output arising from the joint operation; D. Its share of the revenue from the sale of the output by the joint operation; E. The solely-incurred expenses, including its share of any expenses incurred jointly. (2) Joint ventures A joint venture is a joint arrangement whereby the Company only entitled to the net assets of the arrangements. The Company's investment in joint ventures is accounted for using the equity method according to the rules of the long-term equity investment. 8. Determination of cash and cash equivalents Cash and cash equivalents of the Company include cash on hand, bank deposit readily available for payment and those investments held by the Company that are short-term (normally due in three months since the acquisition date), highly liquid, readily convertible into known amounts of cash and subject to an insignificant 176 Joincare Pharmaceutical Group Annual Report 2022 risk of change in value. 9. Foreign currency transactions and translation of financial statements in foreign currency (1) Foreign currency transactions Foreign currency transactions incurred by the Company are translated to the functional currency at the spot exchange rates on the date of the transactions upon initial recognition. Monetary items denominated in foreign currencies are translated to functional currency at the spot exchange rate on the balance sheet date. Exchange differences arising from the differences between the spot exchange rate prevailing at the balance sheet date and those spot rates used on initial recognition or at the previous balance sheet date are recognised in profit or loss for the current period; non-monetary items denominated in foreign currencies that are measured at historical cost are translated using the spot exchange rate on the transaction date. Non-monetary items denominated in foreign currencies that are measured at fair value are translated using the spot exchange rate on the date the fair value is determined; the resulting exchange differences between the amounts in functional currency upon translation and in original functional currency are recognised in profit or loss for the current period. (2) Translation of financial statements in foreign currency At the balance sheet date, when translating the foreign currency financial statements of overseas subsidiaries, the assets and liabilities in the balance sheet are translated at the spot exchange rate at the balance sheet date; all items except for “Retained earnings” of the shareholders' equity are translated at the spot exchange rate on the transaction date. The revenue and expenses in profit or loss are translated at the spot exchange rate on the transaction date. All items in the statement of cash flows are translated at the spot exchange rate on the transaction date. The effect of exchange difference on cash is adjusted and separately presented as “Effect of changes in foreign exchange rates on cash and cash equivalents” in the cash flow statement. The exchange differences arising from translation of the financial statements are presented as the “other comprehensive income” in the shareholders' equity of the balance sheet. When the Company disposes of the overseas operation and loses control, the differences arising from the translation of the financial statements in foreign currency that have been presented under the shareholders' equity in the balance sheet and involving such overseas operation are carried forward to the profit or loss for the current period in whole or in the proportion of the disposal of the overseas operation. 10. Financial instruments Financial instruments are contracts creating financial assets of a party and financial liabilities or equity instruments of other parties. (1) Recognition and Derecognition of financial instruments A financial asset or financial liability is recognised when the Company becomes one of the parties under a financial instrument contract. The financial assets will be derecognised if any of the following conditions is satisfied: ① The contractual right to receive the cash flow of the financial assets is terminated; ② The financial assets have been transferred and the transferred financial asset satisfies the following conditions of derecognition. If the current obligation of a financial liability (or a part thereof) has been discharged, the financial liability (or that part of the financial liability) will be derecognised. When the Company (as the debtor) and the lender 177 Joincare Pharmaceutical Group Annual Report 2022 have signed an agreement which uses a new financial liability to replace the existing financial liability, and the contract terms of the new financial liability are substantially different with the original financial liability, the original financial liability shall be de-recognised, and the new financial liability shall be recognised at the same time. The regular transactions of the financial assets are recognised and derecognised at the transaction date. (2) Classification and measurement of financial assets The Company classifies financial assets into three categories: financial assets at amortised cost; financial assets at fair value through other comprehensive income; and financial assets at fair value through profit or loss based on the business model for managing financial assets and their contractual cash flow characteristics upon initial recognition. Financial assets at amortised cost The Company shall classify financial assets that meet the following conditions and are not designated as financial assets at fair value through profit or loss for the current period as financial assets measured at amortised cost: The Company's business model for managing the financial assets is to collect contractual cash flow; The terms of the financial asset contract stipulate that the cash flow generated on a specific date is only the payment for principal and interest accrued on the outstanding principal. After initial recognition, these financial assets are measured at amortised cost using the effective interest method. Gains or losses arising from financial assets which are measured at amortised cost and not part of any hedging relationship are included in the profit and loss of the current period upon de-recognition, amortisation using the effective interest method, or impairments recognition. Financial assets at fair value through other comprehensive income The Company shall classify financial assets that meet the following conditions and are not designated as financial assets measured at fair value through profit or loss for the current period as financial assets measured at fair value through other comprehensive income The Company's business model for managing the financial assets is both to collect contractual cash flows and to sell the financial assets; The terms of the financial asset contract stipulate that the cash flow generated on a specific date is only the payment for principal and interest accrued on the outstanding principal. After initial recognition, these financial assets are subsequently measured at fair value. Interest, impairment losses or gains and exchange losses and gains calculated using the effective interest method are recognised in profit or loss for the current period, while other gains or losses are recognised in other comprehensive income. The cumulative profit or loss previously included in other comprehensive income will be transferred to the profit or loss for the current period upon derecognition of the financial assets. Financial assets at fair value through profit or loss for the current period In addition to the above financial assets which are measured at amortised cost or at fair value a through other comprehensive income, the Company classifies all other financial assets as financial assets measured at fair value through profit or loss for the current period. When initial recognition, in order to eliminate or significantly reduce accounting mismatches, the Company irrevocably designates some financial assets that should have been measured at amortised cost or at fair value through other comprehensive income as financial assets at fair value through profit or loss for the current period. After initial recognition, these financial assets are subsequently measured at fair value, and the profits or losses (including interest and dividend income) generated from which are recognised in profit or loss for the 178 Joincare Pharmaceutical Group Annual Report 2022 current period, unless the financial assets are part of the hedging relationship. However, with respect to non-trading equity instrument investments, the Company may irrevocably designate them as financial assets measured at fair value through other comprehensive income at initial recognition. The designation is made on the basis of individual investment, and the relevant investment conforms to the definition of equity instruments from the issuer's point of view. After initial confirmation, financial assets are subsequently measured at fair value. Dividend income that meets the requirements is recognised in profit and loss, and other gains or losses and changes in fair value are recognised in other comprehensive gains. When derecognised, the accumulated gains or losses previously recognised in other comprehensive gains are transferred from other comprehensive gains to retained earnings. The business model of managing financial assets refers to how the Company manages financial assets to generate cash flow. The business model decides whether the source of cash flow of financial assets managed by the Company is to collect contract cash flow, sell financial assets or both of them. Based on objective facts and the specific business objectives of financial assets management decided by key managers, the Company determines the business model of financial assets management. The Company evaluates the characteristics of the contract cash flow of financial assets to determine whether the contract cash flow generated by the relevant financial assets on a specific date is only to pay principal and interest based on the amount of unpaid principal. Among them, principal refers to the fair value of financial assets at the time of initial confirmation; interest includes the consideration of time value of money, credit risk related to the amount of unpaid principal in a specific period, and other basic borrowing risks, costs and profits. In addition, the Company evaluates the terms and conditions of the contracts that may lead to changes in the time distribution or amount of cash flow in financial asset contracts to determine whether they meet the requirements of the above contract cash flow's characteristics. Only when the Company changes its business model of managing financial assets, all the financial assets affected shall be reclassified on the first day of the first reporting period after the business model changes, otherwise, financial assets shall not be reclassified after initial confirmation. Financial assets are measured at fair value on initial recognition. The relevant transaction cost of financial assets at fair value through profit or loss is directly recognised in profit or loss for the current period, and that of other types of financial assets is included in the initially recognised amount. Trade receivables or notes receivable arising from sales of goods or rendering services, without significant financing component, are initially recognised based on the transaction price expected to be entitled by the Company. (3) Classification and measurement of financial liabilities On initial recognition, the Company's financial liabilities are classified into financial liabilities at fair value through profit or loss and financial liabilities at amortised cost. For financial liabilities not classified as financial liabilities at fair value through profit or loss, the relevant transaction costs are included in the initially recognised amount. Financial liabilities at fair value through profit or loss Financial liabilities at fair value through profit or loss include financial liabilities held for trading and financial liabilities designated at fair value through profit or loss upon initial recognition. Such financial liabilities are subsequently measured at fair value, all gains and losses arising from changes in fair value and dividend and interest expense relative to the financial liabilities are recognised in profit or loss for the current period. Financial liabilities at amortised cost Other financial liabilities are subsequently measured at amortised cost using the effective interest method; gains and losses arising from derecognition or amortisation is recognised in profit or loss for the current period. 179 Joincare Pharmaceutical Group Annual Report 2022 Distinction between financial liabilities and equity instruments The financial liability is the liability that meets one of following criteria: ① Contractual obligation to deliver cash or other financial instruments to another entity. ② Under potential adverse condition, contractual obligation to exchange financial assets or financial liabilities with other parties. ③ A contract that will or may be settled in the entity's own equity instruments and is a non-derivative for which the entity is or may be obliged to deliver a variable number of the entity's own equity instruments. ④ A derivative that will or may be settled other than by the exchange of a fixed amount of cash or another financial asset for a fixed number of the entity's own equity instruments. An equity instrument is any contract that evidences a residual interest in the assets of an entity after deducting all of its liabilities. If the Company cannot unconditionally avoid fulfilling a contractual obligation by delivering cash or other financial assets, the contractual obligation meets the definition of financial liability. If a financial instrument must or are able to be settled by the Company's own equity instrument, the Company should consider whether the Company's equity instrument as the settlement instrument is a substitute of cash or other financial assets or the residual interest in the assets of the Company after deducting all of its liabilities. If the former, the tool is the Company's financial liability; if the latter, the tool is the equity instrument of the Company. (4) Derivative financial instruments and embedded derivatives The Company's derivative financial instruments include forward foreign exchange contracts, and are initially measured at fair value on the date of the derivative contract signed and are subsequently measured at fair value. A derivative with positive fair value shall be recognised as an asset, otherwise that with negative fair value shall be recognised as a liability. Any profit or loss arising from changes of fair value and not compliance with the accounting provision of hedge shall be recognised as profit or loss for current period. For the hybrid instrument which includes embedded derivatives, where the host contract is a financial asset, requirements in relation to the classification of financial assets shall apply to the hybrid instrument as a whole. Where the host contract is not a financial asset, and the hybrid instrument is not measured at fair value and its changes are included in the profit and loss for the current period for accounting purposes, there is no close relation between the embedded derivatives and the host contract in terms of economic features and risks, and the instrument that has the same condition with the embedded derivatives and exists independently meets the definition of derivatives, the embedded derivatives shall be separated from the hybrid instrument and treated as a separate derivative financial instrument. If it is unable to separately measure the embedded derivatives upon acquisition or on the subsequent balance sheet date, the hybrid instrument shall be entirely designated as the financial assets or financial liabilities measured at fair value and whose movements are included in the profit and loss of the current period. (5) Fair value of the financial instrument The methods for determining the fair value of the financial assets or financial liabilities are set out in Note III.11. (6) Impairment of financial assets The following items are subject to impairment accounting and recognition of loss allowances based on expected credit losses: A. Financial assets measured at amortised cost; 180 Joincare Pharmaceutical Group Annual Report 2022 B. Receivables and debt investments that are measured at fair value through other comprehensive income; C. Contract assets as defined in the Accounting Standard for Business Enterprises No. 14 – Revenue; D. Lease receivables; E. Financial guarantee contracts, except for those carried at fair value through profit or loss, those which the transfer of financial assets does not satisfy the derecognition condition or those formed as a result of continued involvement of the transferred financial assets. Measurement of expected credit loss (ECLs) The ECL is a weighted average of credit losses on financial instruments weighted at the risk of default. Credit loss is the difference between all receivable contractual cash flows according to the contract and all cash flows expected to be received by the Company discounted to present value at the original effective interest rate, i.e. the present value of all cash shortfalls. The Company takes into account reasonable and valid information on past events, current conditions and forecasts of future economic conditions, with the risk of default as the weight, to calculate the probabilistic weighted amount of the present value of the difference between the cash flow receivable from contract and the expected cash flow to be received and recognise the expected credit loss. The Company respectively measures the expected credit losses of financial instruments by different stages. If the credit risk of the financial instrument does not increase significantly since the initial recognition, it would be classified in Stage 1, the Company would measure loss allowance according to the future 12-month expected credit losses. If the credit risk of a financial instrument has significantly increased since the initial recognition but not yet credit-impaired, it would be classified in Stage 2, the Company would measure loss allowance according to the lifetime expected credit losses of that instrument. If the financial instrument has credit-impaired since the initial recognition, it would be classified in Stage 3, and the Company would measure loss allowance according to the lifetime expected credit losses of that instrument. For financial instruments with lower credit risk on the balance sheet date, the Company assumes that its credit risk has not increased significantly since the initial recognition, and measures loss allowance according to the 12-month expected credit losses. Lifetime ECLs are the ECLs that result from all possible default event over the expected life of a financial instrument. Future 12-month ECLs are the portion of ECL that results from default events on a financial instrument that are possible within the 12 months after the balance sheet date (or the expected life of the instrument, if it is less than 12 months). The maximum period considered when estimating ECLs is the maximum contractual period over which the Company are exposed to credit risk (including the option to renew). For the financial instruments classified in Stage 1 and Stage 2 and those with lower credit risk, the Company would measure the interest income by the book balance (that is, without deduction for credit allowance) and the effective interest rate. For financial instruments classified in Stage 3, the Company would measure the interest income by the amortised cost (that is, book balance less impairment allowance) and the effective interest rate. For notes receivable, trade receivables and contract assets, regardless whether it has significant financing components or not, the Company has always measured its loss allowance at an amount equal to lifetime expected credit losses. If the expected credit losses of one individual financial asset cannot be estimated at a reasonable cost, the Company classifies notes receivable and trade receivables into portfolios based on credit risk characteristics, and measures expected credit losses on portfolios basis to determine portfolios by the following basis: A. Notes receivable 181 Joincare Pharmaceutical Group Annual Report 2022 Bills receivable portfolio 1: Bank acceptance bills Bills receivable portfolio 2: Commercial acceptance bills B. Accounts receivables Accounts receivables portfolio 1: Amount due from domestic customers Accounts receivables portfolio 2: Amount due from overseas customers Accounts receivables portfolio 3: Receivables of consolidated companies Contract assets Contract assets portfolio: Sale of products For bills receivable classified as portfolio, the Company measures expected credit losses based on the risk exposures of default and lifetime expected credit losses rate with reference to the historical credit loss experience, current situation and forecasts of future economic conditions. For accounts receivables classified as portfolio, the Company measures expected credit losses through preparing a table of concordance between the aging of trade receivables and lifetime expected credit losses rate with reference to the historical credit loss experience, current situation and forecasts of future economic conditions. Other receivables The Company classifies other receivables into certain portfolios based on credit risk characteristics, and measures expected credit losses on portfolios basis to determine portfolios by the following basis: Other receivables portfolio 1: Receivables of export tax refund Other receivables portfolio 2: Receivables of deposits under guarantee and security deposits and lease expenses Other receivables portfolio 3: Other receivables Other receivables portfolio 4: Receivables of consolidated companies For other receivables classified as portfolio, the Company measures expected credit losses based on the risk exposures of default and future 12-month or lifetime expected credit losses rate. Long-term receivables The Company's long-term receivables include finance lease receivables and equity transfer receivables. The Company classifies finance lease receivables and equity transfer receivables into certain portfolios based on credit risk characteristics, and measures expected credit losses on portfolios basis to determine portfolios by the following basis: A. Finance lease receivables Portfolio of finance lease receivables: other receivables B. Other long-term receivables Portfolio of other long-term receivables: equity transfer receivables For finance lease receivables and equity transfer receivables, the Company measures expected credit losses based on the risk exposures of default and lifetime expected credit losses rate with reference to the historical 182 Joincare Pharmaceutical Group Annual Report 2022 credit loss experience, current situation and forecasts of future economic conditions. For other receivables and long-term receivables other than finance lease receivables and equity transfer receivables that are classified as portfolio, the Company measures expected credit losses based on the risk exposures of default and future 12-month or lifetime expected credit losses rate. Debt investments and other debt investments For debt investments and other debt investments, the Company measures expected credit losses based on the nature of investments, counterparties and various types of risk exposures and the risk exposures of default and future 12-month or lifetime expected credit losses rate. Assessment of significant increase in credit risk By comparing the risk of default of financial instruments occurring on the balance sheet date and on the initial recognition date, the Company determines the relative changes in risk of default over the expected life of financial instruments and assesses whether the credit risk of financial instruments have increased significantly since the initial recognition. When determine whether credit risks have significantly increased since the initial recognition, the Company considers information that is reasonable and supportable, including forward-looking information that is available without undue cost or effort. The information considered by the Company includes: Failure to make payments of principal or interest on debtors' contractually due dates; An actual or expected significant deterioration in a financial instrument's external or internal credit rating (if any); An actual or expected significant deterioration in the operating results of debtors; Existing or forecast changes in the technological, market, economic or legal environment that have significant adverse effect on the debtors' abilities to repay to the Company. Depending on the nature of the financial instruments, the Company assesses whether credit risks have significantly increased on either an individual financial instrument basis or a collective financial instrument basis. When the assessment is performed on a collective financial instrument basis, the Company can classify the financial instruments based on the shared credit risk characteristics, such as past due information and credit risk ratings. The Company determines that the credit risk on a financial instrument has increased significantly if it is more than 30 days past due. Credit-impaired financial assets The Company assesses whether financial assets at amortised cost and debt investments measured at fair value through other comprehensive income are credit-impaired at balance sheet date. A financial asset is “credit- impaired” when one or more events that have an adverse impact on the estimated future cash flows of the financial asset have occurred. Evidence that a financial asset is credit-impaired includes the following observable information: Significant financial difficulty of the issuer or debtor; A breach of contract by debtor, such as a default or delinquency in interest or principal payments; For economic or contractual reasons relating to the borrower's financial difficulty, the Company having granted to the borrower a concession that would not otherwise consider; It is probable that the borrower will enter bankruptcy or other financial reorganization; 183 Joincare Pharmaceutical Group Annual Report 2022 The disappearance of an active market for that financial asset because of financial difficulties. Presentation of allowance for ECL The Company re-measures the ECLs on each balance sheet date to reflect changes in the financial instruments' credit risk since initial recognition, and the increase or reversal of the loss provision resulted therefrom is recognised as an impairment gain or loss in profit or loss. For financial assets measured at amortised cost, the loss provision is offset against their carrying amounts in the balance sheet. For debt investments at FVOCI, the Company recognises the loss provision in other comprehensive income and does not deduct the carrying amount of the financial assets. Write-off The gross carrying amount of a financial asset is written off (either partially or in full) to the extent that there is no realistic prospect of recovery. A write-off constitutes a derecognition event. This is generally the case the Company determines that the debtor does not have assets or sources of income that could generate sufficient cash flows to repay the amounts subject to the write-off. However, financial assets that are written off could still be subject to enforcement activities in order to comply with the Company's procedures for recovery of amounts due. Subsequent recoveries of an asset that was previously written off are recognised as a reversal of impairment in profit or loss in the period in which the recovery occurs. (7) Transfer of financial assets Transfer of financial assets refers to the transfer or delivery of financial assets to the other party (the transferee) other than the issuer of financial assets. The Company derecognises a financial asset only if it transfers substantially all the risks and rewards of ownership of the financial asset to the transferee; the Company should not derecognise a financial asset if it retains substantially all the risks and rewards of ownership of the financial asset. The Company neither transfers nor retains substantially all the risks and rewards of ownership, shows as the following circumstances: if the Company has forgone control over the financial assets, derecognise the financial assets and verify the assets and liabilities; if the Company retains its control of the financial asset, the financial asset is recognised to the extent of its continuing involvement in the transferred financial asset and recognise an associated liability is recognised. (8) Offsetting financial assets and financial liabilities When the Company has the legal right to offset recognised financial assets and financial liabilities, and the legal right can be executed at present, and the Company has a plan to settle the financial assets and financial liabilities at the same time or at net amount, the financial assets and financial liabilities can be presented on the balance sheet after offsetting. Except for the above circumstances, financial assets and financial liabilities cannot be offset and shall be presented separately on the balance sheet. 11. Fair value measurement The fair value is defined as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The Company measures the relevant assets or liability at fair value supposing the orderly transaction of asset selling or liability transferring incurring in a principal market of relevant assets or liabilities. In the absence of a principal market for the asset or liability, the Company assumes that the transaction takes place at the most advantageous market of relevant asset or liability. A principal market (or the most advantageous market) is the transaction market that the Company can enter into at measurement date. The Company implements the hypothesis used by the market participants to realise the maximum economic benefit in assets or liabilities pricing. 184 Joincare Pharmaceutical Group Annual Report 2022 If there exists an active market for the financial assets or financial liabilities, the Company uses the quotation on the active market as its fair value. For those in the absence of active market, the Company uses valuation technique to recognise its fair value. However, under limited circumstances, the Company may use all information about the results and operation of the investee obtained after the date of initial recognition to determine whether cost represents fair value. Cost may represent the best estimate of fair value of the relevant financial asset within the scope of distribution, and such cost represents the appropriate estimate of fair value within the scope of distribution. For non-financial assets measured at fair value, the Company should consider the capacity of the market participants to put the assets into optimal use thus generating the economic benefit, or the capacity to sell assets to other market participants who can put the assets into optimal use and generate economic benefit. The Company implements the valuation technique suitable for the current condition and supported by enough available data and other information, gives priority in use of relevant observable inputs, only the observable inputs cannot be obtained or impracticable before using unobservable inputs. For the assets and liabilities measured or disclosed at fair value on financial statements, fair value hierarchies are categorized into three levels as the lowest level input that is significant to the entire fair value measurement: Level 1: inputs are quoted prices (unadjusted) in active markets for identical assets and liabilities. Level 2: inputs are inputs other than quoted prices included within Level 1 that are observable for the asset or liability, either directly or indirectly. Level 3: inputs are unobservable inputs for the asset or liability. At each balance sheet date, the Company re-evaluates the assets and liabilities recognised to be measured at fair value on the financial statements to make sure whether conversion occurs between fair value hierarchies. 12. Inventories (1) Classification of inventories The Company's inventories include raw materials, packaging materials, finished goods, work-in-progress, low-value consumables, subcontracting materials, inventory goods, expendable biological assets and goods in transit. (2) Method of costing The method of costing of the Company's inventories: Cost of finished goods are measured at planned cost, and material cost differences are carried forward at the end of the period to adjust planned cost to actual cost; other inventories are measured at actual cost on acquisition and raw materials received are accounted for by the weighted-average method; low-value consumables and packaging materials are amortised in full upon the use. (3) Method in the determination and the basis of provision for diminution in net realisable value of inventories On the balance sheet date, the inventories are calculated at the lower of cost and the net realisable value. When the net realisable value is lower than the cost, the provision for diminution in value of inventories is made on an item-by-item basis at the excess of the cost of the inventory over its net realisable value. For large volume inventories with low unit price, the provision for diminution in the value of inventories is made by categories. Inventories that are related to a product line manufactured and sold in the same region, have the same or similar end use or purpose, and are difficult to measure separately from other items are consolidated the provision for diminution in the value of inventories. (4) Inventory system The Company maintains a perpetual inventory system. (5) Amortisation methods of consumables and packaging materials Low-value consumables and packaging materials of the Company are amortised in full when used. 185 Joincare Pharmaceutical Group Annual Report 2022 13. Held for sale and discontinued operations (1) Category and measurement of non-current assets or the disposal group held for sale Non-current assets and disposal groups are classified as held for sale if the Company recovers its book value mainly by selling (including the exchange of nonmonetary assets with commercial substance) rather than continuing to use it. The aforesaid non-current assets do not include investment property measured with the basis of fair value; the biological assets measured with the basis of fair value less selling costs; the assets formed by employee benefits; financial assets and the right arising from deferred income tax assets and insurance contracts. A disposal group is a group of assets to be disposed through sale or other means as a whole in a single transaction, and liabilities directly associated with those assets that will be transferred in the transaction. In certain circumstance, disposal groups include the goodwill obtained through business combination. Non-current assets and disposal groups that meet the following conditions are classified as held for sale: according to the practice of disposing of this type of assets or disposal groups in a similar transaction, a non- current asset or disposal group is available for immediate sale at its present condition; the sale is likely to occur, that is, a decision has been made on a sale plan and a determined purchase commitment is made, and the sale is expected to be completed within one year. Where the loss of control over the subsidiaries is due to the sales of investment in subsidiaries, no matter whether the Company retains part of the equity investment after selling or not, the investment in subsidiaries shall be classified as held for sale in the separate financial statements when it satisfies the conditions for category of held for sale; all assets and liabilities of subsidiaries shall be classified as held for sale in the consolidated financial statements. The difference between carrying amount of non-current assets or disposal groups classified as held for sale and the net amount of fair value less selling costs shall be recognised as impairment loss on assets upon initial measurement or when such non-current assets or disposal groups are remeasured at the balance sheet date. For the amount of impairment loss on assets recognised in disposal groups, the carrying amount of disposal groups' goodwill shall be offset against first, and then offset against the carrying amount of non-current assets according to the proportion of carrying amount of the individual non-current assets in the disposal groups. If on a subsequent balance sheet date, the net amount of the fair value of a held-for-sale disposal group less its selling costs increases, the amount reduced previously shall be recovered, and reversed in the asset impairment loss recognised on the noncurrent asset which is applicable to the measurement requirements of Held-For-Sale Standards after the non-current asset is classified into held-for-sale category. The reversed amount is credited to current profit or loss. The carrying value of goodwill which has been offset cannot be reversed. No depreciation or amortisation is provided for the non-current assets in the held-for-sale and the assets in the disposal group held for sale. The interest on the liabilities and other costs in the disposal group held for sale is recognised continuously. As far as all or part of investment in the associates and joint ventures is concerned, for the part classified into the held-for-sale category, the accounting with equity method shall be stopped, while the remaining part (which is not classified into the held for- sale category) shall still be accounted for using the equity method. When the Company loses the significant influence on the associates and joint venture due to the sale, the use of equity method shall be ceased. When certain non-current asset or disposal group classified into the held-for-sale category no longer meets the classification criteria for held-for-sale category, the Company shall stop classifying it into the held-for- sale category and measure it according to the lower of the following two amounts: ① The carrying amount of the asset of disposal group before it was classified into the held-for-sale category after being adjusted with the depreciation, amortisation or impairment that could have been be recognised if it was not classified into the held-for-sale category; ② The recoverable amount. 186 Joincare Pharmaceutical Group Annual Report 2022 (2) Discontinued operation Discontinued operation refers to the component meeting one of the following conditions that has been disposed of by the Company or classified by the Company into the held-for-sale type and can be identified separately: ① The component represents an independent principal business or a separate principal business place. ② The component is a part of the related plan for the contemplated disposal of an independent principal business or a separate principal business place. ③ The component is a subsidiary acquired exclusively for the purpose of resale. (3) Presentation The Company presents the non-current assets held for sale and the assets in the disposal group held for sale under “assets classified as held for sale”, and the liabilities in the disposal group held for sale under “liabilities classified as held for sale” in the balance sheet. The Company presents the profit and loss for continuing operation and profit and loss for discontinued operation in the income statement, respectively. The impairment loss and reversal amount and disposal profit and loss of the non-current assets held for sale or disposal group not meeting the definition of discontinued operation will be presented as the profit and loss of continuing operation. The operating profit and loss (such as impairment loss and reversal amount) and disposal profit and loss of the discontinued operation will be presented as the profit and loss of the discontinued operation. The disposal group proposed for retirement rather than sale and meeting the condition about the relevant component in the definition of the discontinued operation will be presented as discontinued operation from the date of retirement. For the discontinued operation reported in the current period, the information formerly presented as profit and loss of continuing operation will be presented as the profit and loss of discontinued operation for the comparable accounting period in the financial statement of the current period. If the discontinued operation no longer meets the classification criteria for held-for-sale category, the information formerly presented as profit and loss of discontinued operation will be presented as the profit and loss of continuing operation for the comparable accounting period in the financial statement of the current period. 14. Long-term equity investment The long-term equity investment includes the equity investment in the subsidiary, joint ventures and associates. The investee over which the Company has significant influence is the associates of the Company. (1) Determination of initial investment cost The long-term equity investment resulting from corporate merger: For the long-term equity investment resulting from merger of companies under the same control, the carrying amount of the ownership equity of the merged party obtained on the merger date presented in the consolidated financial statement of the final controlling party will be used as the investment cost. For the long-term equity investment resulting from merger of companies under different controls, the merger cost will be used as the investment cost of the long- term equity investment. The long-term equity investment obtained by other means: For the long-term equity investment obtained by paying cash, the actually paid purchase price will be used as the initial investment cost. For the long term equity investment obtained by issuing equity securities, the fair value of the issued equity securities will be used as the initial investment cost. (2) Subsequent measurement and recognition method of profit or loss 187 Joincare Pharmaceutical Group Annual Report 2022 The investment in subsidiary will be accounted for using cost method, unless the investment meets the criteria of held-for-sale category. The investment in associates and joint venture will be accounted with equity method. For the long-term equity investment accounted for using cost method, except for the price actually paid upon the investment or the cash dividend or profit in the consideration that has been declared but not released, the cash dividend or profit declared and distributed by the investee is recognised as the investment income and recorded into the profit and loss for the current period. For the long-term equity investment accounted for using equity method, the investment cost of the long-term equity investment shall not be adjusted if the initial investment cost of the long-term equity investment is higher than the Company's share in the fair value of the identifiable net value of the investee at the time of investment; if the initial investment cost of the long-term equity investment is lower than the Company's share in the fair value of the identifiable net value of the investee at the time of investment, the carrying amount of the long-term equity investment will be adjusted, with the difference recorded into the profit and loss for the current period of investment. When accounted for using the equity method, return on investment and other comprehensive income are recognised according to the share in the investee's realised net profit or loss and other comprehensive income respectively, and the carrying amount of the long-term equity investment is adjusted. The carrying amount of the long-term equity investment will be deducted according to the profit distribution declared by the investee or cash dividend attributable to the Company. The carrying amount of long term equity investment will be adjusted for changes to equity interest attributable to the owners of the investee other than net profit or loss, other comprehensive income and profit distribution, and recorded into capital reserve (other capital reserve). The Company's share of the net profit or loss of the investees will be recognised after adjustment of the net profit of the investees according to the accounting policy and accounting period of the Company on the basis of fair value of all identifiable assets of the investee on acquisition. If the Company is able to exert significant influence or implement joint control (which does not constitute control) on the investee through additional investment or other reason, the sum of the fair value of the original equity plus the additional investment cost will be used as the initial investment cost, which will be accounted for with equity method, on the conversion date. The difference between the fair value of the original equity on the conversion date and its carrying amount, and the accumulated change of fair value recorded into other comprehensive income will be transferred into the profit and loss for the current period, which will be accounted for using equity method. If an entity loses joint control or has no significant influence over investees due to the elimination of parts of the equity investment, the surplus equity after disposal shall be recognised in accordance with “Accounting Standards for Business Enterprises No. 22 – Recognition and Measurement of Financial Instruments”, and the difference between fair value and carrying amount should be recognised as profit or loss for current period. Other comprehensive income of original equity investment recognised under equity method shall be recognised in accordance with the same foundation used by the investees when dispose the relevant assets or liabilities directly in the termination of equity method. Other changes of owners' equity related to the original equity investment shall be transferred into profit or loss for current period. If an entity loses control over investees due to the elimination of parts of the equity investment, the surplus owners' equity that is able to implement joint control or have significant influence over investees shall be measured at equity method and are deemed to be recognised under equity method since the acquisition date. The surplus owners' equity that are unable to implement joint control or have no significant influence over investees shall be processed in accordance with “Accounting Standards for Business Enterprises No. 22 – Recognition and Measurement of Financial Instruments”, and the difference between fair value and carrying amount at the day of loss of control shall be recognised as profit or loss for current period. If the shareholding ratio of the Company is reduced due to the increase of capital of other investors, and thus the control is lost, but the joint control or significant influence can be exerted on the invested entity, the Company should recognise net asset according to the new shareholding ratio. The difference between the original book value of the long-term equity investment corresponding to the decrease in the shareholding ratio should be included in the current profit and loss; then, according to the new shareholding ratio, the 188 Joincare Pharmaceutical Group Annual Report 2022 equity method is used to adjust the investment. The Company recognises the unrealised profit or loss of intra-transaction between the joint ventures or associates that belongs to itself according to the proportion of the shares and recognises the investment income or loss after offset. However, the loss arising from the unrealised intra-transaction between the Company and investees, which belongs to the impairment loss of assets transferred, cannot be offset. (3) Basis of determining common control and significant influence on the investee Joint control is the contractually agreed sharing of control over an arrangement under which the decisions relating to any activity require the unanimous consent of the parties sharing control. In determining whether there is a joint control, the first judge is to determine whether the relevant arrangement is controlled collectively by all the parties involved or the group of the parties involved. Secondly, and then determine whether the decisions related to the basic operating activities should require the unanimous consent of the parties involved. If the parties involved or the group of the parties involved must act consistently to determine the relevant arrangement, it is considered that the parties involved or the group of the parties involved control the arrangement. If two or more parties involve in the collectively control of certain arrangement, it shall not be considered as joint control. Protection of rights shall not be considered in determining whether there is joint control. Significant influence refers to the power to participate in the decision making process for financial and operational policies of the investees without control or common control over the formulation of such policies. When determining whether it has significant influence over the investee, the influence of the voting shares of the investee held by the investor directly and indirectly and the potential voting rights held by the investor and other parties which are exercisable in the current period and converted to the equity of the investee, including the warrants, stock options and convertible bonds that are issued by the investee and can be converted in the current period, shall be taken into account. When the Company owns directly or indirectly through its subsidiaries more than 20% (including 20%) but less than 50% of the voting shares of the investee, it is generally considered to have significant influence over the investee, unless there is clear evidence that it cannot participate in the production and operation decisions of the investee and does not have a significant influence under such circumstances. When the Company owns less than 20% (excluding) of the voting shares of the investee, it is generally not considered to have significant influence on the investee unless there is clear evidence that it can participate in the production and operation decisions of the investee and have significant influence under such circumstances. (4) Held-for-sale equity investment Refer to Note III. 13 for the relevant accounting treatment of the equity investment to joint ventures or associates all or partially classified as assets held for sale. The surplus equity investments that are not classified as assets held for sale shall be accounted for using equity method. The equity investment to joint ventures or associates already classified as held for sale no longer meets the conditions of assets held for sale shall be adjusted retroactively using equity method from the date of being classified as assets held for sale. (5) Impairment test and impairment provision Refer to note III. 22 for investment to subsidiaries, associates and joint ventures and the impairment provision of assets. 15. Investment properties Investment properties are properties held to earn rental or capital appreciation or both. The investment properties of the Company include land use rights that have already been leased out, land use rights that are held for the purpose of sale after capital appreciation, buildings that have already been leased out, etc. 189 Joincare Pharmaceutical Group Annual Report 2022 Investment properties of the Company are measured initially at cost upon acquisition, and subject to depreciation or amortisation in the relevant periods according to the relevant provisions on fixed assets or intangible assets. The Company adopts the cost model for subsequent measurement of the investment properties. The method for asset impairment provision is set out in note III. 22. The balance after the disposal income from the disposal, transfer, scrapping or destruction of the investment properties deducts the book value and the relevant taxes shall be recorded into the profit and loss for the current period. 16. Fixed asset (1) Conditions for recognition of fixed assets The Company's fixed assets represent the tangible assets held by the Company using in the production of goods, rendering of services, rent and for operation and administrative purposes with useful life over one year. The fixed asset can be recognised only when the economic benefit related to the fixed asset is probable to flow into the company and the cost of the fixed asset can be reliably measured. The Company's fixed assets are initially measured at the actual cost at the time of acquisition. (2) Method of depreciation The Company adopts the straight-line method to provision for depreciation. Depreciation of fixed assets begins when they reach the status of intended use, and ceases to be depreciated when they are derecognized or classified as non-current assets held for sale. Without taking into account the provision for impairment, the Company determines the annual depreciation rates of various types of fixed assets according to the type of fixed assets, estimated useful life and estimated residual value as follows: Category Useful years (year) Annual depreciation Residual rate % Properties and Buildings 20 4.5%-4.75% 5%-10% Machine and equipment 10 9%-9.5% 5%-10% Transportation equipment 5 18%-19% 5%-10% Electric equipment and others 5-10 18%-19% 5%-10% Where, for the fixed assets for which depreciation provision is made, to determine the depreciation rate, the accumulated amount of the fixed asset depreciation provision that has been made shall be deducted. (3) Refer to note III. 22 for the impairment testing and the impairment provision of fixed assets. (4) Recognition basis, valuation and depreciation method of financial leased fixed assets When the Company's leased fixed assets meet one or more of the following criteria, it is recognized as finance leased fixed assets: ① At the expiration of the lease term, the ownership of the leased assets is transferred to the Company. ② The Company has the option to purchase leased assets. The agreed purchase price is expected to be much lower than the fair value of the leased asset when the option is exercised. Therefore, it can be reasonably determined that the Company will exercise this option on the lease start date. ③ Even if the ownership of the asset is not transferred, the lease term occupies most of the useful life of the leased asset. 190 Joincare Pharmaceutical Group Annual Report 2022 ④ The present value of the Company's minimum lease payment on the lease start date is almost equivalent to the fair value of the leased assets on the lease start date. ⑤The leased assets are of special nature, and only our company can use them if they don't undergo major transformation. For fixed assets leased by finance leases, the lower of the fair value of the leased assets on the lease start date and the present value of the minimum lease payment shall be the entry value. The minimum lease payment is taken as the entry value of the long-term payable, and the difference is taken as the unrecognized financing expense. In the process of lease negotiation and signing of the lease contract, the initial direct costs attributable to the lease item, such as handling fees, attorney fees, travel expenses, stamp duty, etc., are included in the value of the leased asset. The unrecognized financing costs shall be amortized by the effective interest method during each period of the lease term. The fixed assets acquired by finance lease adopt the same policy as self-owned fixed assets to calculate the depreciation of leased assets. If it can be reasonably determined that the ownership of the leased asset will be obtained at the end of the lease term, depreciation shall be accrued on the useful life of the leased asset; if it cannot be reasonably determined that the ownership of the leased asset will be obtained at the end of the lease term, depreciation is accrued in the shorter of the lease period and the useful life of the leased asset. (5) The Company reviews the useful life and estimated net residual value of fixed asset and the depreciation method applied annually at each of the period end. The useful lives of fixed asset are adjusted if their expected useful lives are different from the original estimates; the estimated net residual values are adjusted if they are different from the original estimates. (6) Overhaul costs The overhaul costs occurred in regular inspection of f are recognised in the cost of property, plant and equipment if there is undoubted evidence to confirm that they meet the recognition criteria of fixed assets, otherwise, the overhaul costs are recognised in profit or loss for the current period. Property, plant and equipment are depreciated during the intervals of the regular overhaul. 17. Construction in progress Construction in progress is measured at actual cost. Actual cost comprises necessary project expenditure incurred during construction, borrowing cost that are eligible for capitalisation and other necessary cost incurred to bring the fixed assets ready for their intended use. Construction in progress is transferred to fixed assets when the assets are ready for their intended use. For provision for impairment of construction in progress, refer to note III. 22. In the balance sheet, the ending balance of construction materials is presented under “construction in progress”. 18. Borrowing costs (1) Recognition principle of capitalisation of borrowing costs For borrowing costs that are directly attributable to the acquisition, construction or production of a qualifying asset, they shall be capitalised and included in the cost of related assets; other borrowing costs are recognised as expenses and included in profit or loss when incurred. Capitalisation of such borrowing costs can commence only when all of the following conditions are satisfied: ① Expenditures for the asset incurred, capital expenditure includes the expenditure in the form of cash payment, transfer of non-cash assets or the interest bearing liabilities for the purpose of acquiring or constructing assets eligible for capitalisation; 191 Joincare Pharmaceutical Group Annual Report 2022 ② Borrowing costs incurred; ③ Activities relating to the acquisition, construction or production of the asset that are necessary to prepare the asset for its intended use or sale have commenced. (2) Capitalisation period of borrowing costs Capitalisation of such borrowing costs ceases when the qualifying assets being acquired, constructed or produced become ready for their intended use or sale. The borrowing cost incurred after that is recognised as an expense in the period in which they are incurred and included in profit or loss for the current period. Capitalisation of borrowing costs is suspended during periods in which the acquisition, construction or production of a qualifying asset is interrupted abnormally and when the interruption is for a continuous period of more than 3 months; the borrowing costs in the normally interrupted period continue to capitalise. (3) Calculation of the capitalisation rate and amount of borrowing costs The interest expense of the specific borrowings incurred at the current period, deducting any interest income earned from depositing the unused specific borrowings in bank or the investment income arising from temporary investment, shall be capitalised. The capitalisation rate of the general borrowing is determined by applying the weighted average effective interest rate of general borrowings, to the weighted average of the excess amount of cumulative expenditures on the asset over the amount of specific borrowings. During the capitalisation period, exchange differences on foreign currency special borrowings shall be capitalised; exchange differences on foreign currency special borrowings shall be recognised as current profits or losses. 19. Biological assets (1) Determination of biological assets Biological assets refer to assets comprising living animals and plants. No biological asset shall be recognised unless it meets the conditions as follows simultaneously: ① An enterprise possesses or controls the biological asset as a result of past transaction or event; ② The economic benefits or service potential concerning this biological asset are likely to flow into the enterprise; ③ The cost of this biological asset can be measured reliably. (2) Classification of biological assets The Company’s biological assets are consumable biological assets which include traditional Chinese medical herbal plant species. The consumable biological assets refer to the biological assets held for sale, or biological assets to be harvested as agricultural products in the future, consisting of growing traditional Chinese medical herbal plant species. The consumable biological asset is initially measured at cost. The cost of any consumable biological assets by way of self-planting, self-cultivating, self-breading is the necessary cost directly attributable to this asset prior to the harvest, consisting of borrowing costs that meet the conditions of capitalisation. The subsequent expenses for the maintenance, protection and cultivation of a consumable biological asset after the harvest shall be included in the current profits or loss. The cost of a consumable biological asset shall, at the time of harvest or sale, be carried over at its book value by the weighted average method. (3) Impairment of biological assets 192 Joincare Pharmaceutical Group Annual Report 2022 If the net realisable value of the consumable biological assets is lower than their carrying amount, provision of impairment loss is made and recognised in the profit or loss for the current period as the excess of the carrying amount over the net realisable value. If the factors affecting the impairment of consumable biological assets no longer exist, the amount of write-down shall be resumed and shall be reversed from the original provision for the impairment loss before being recognised in the profit or loss for the current period. 20. Intangible assets An intangible asset is an identifiable non-monetary asset without physical substance owned or controlled by the Company. An intangible asset is recognised only when all of the following conditions are satisfied: It is probable that the economic benefits associated with the intangible assets will flow to the enterprise; The cost of the intangible asset can be reliably measured. Intangible assets are initially measured at actual cost. The Company's intangible assets include land use rights, patents and proprietary technologies, software, trademark rights, etc. Intangible assets are initially measured at historical cost, and the Company shall make judgement to determine the useful life of intangible assets upon acquisition. Intangible assets with finite useful life are amortised in the profit or loss over the estimated useful life, using the method that reflects the expected realisation of economic benefits associated with the asset, and if the expected realisation cannot be reliably determined, it is amortised using the straight-line method. Intangible assets with indefinite useful life is not amortised. Amortisation of intangible assets with finite useful life is as follows: Category Expected useful life Amortization method Note Land use rights 30-50 years Straight-line Patent and technical know-how 1-10 years Straight-line Software 2-10 years Straight-line Trademark rights 5 years Straight-line Others 10 years Straight-line The useful life for an intangible asset with a finite useful life and the method of amortisation are reviewed at least once at the end of each financial year. If the useful life and amortisation method for the intangible assets are different from the previous estimate, the change of amortisation is recognised prospectively as the change of accounting estimate. When the Company estimates an intangible asset can no longer bring future economic benefits to the Company at the end of a period, the carrying amount in which should be reversed to profit or loss for the current period. Please refer to note III. 22 for the provision of impairment of intangible assets. 21. Research and development expenditures Expenditures on an internal research and development project are classified into expenditures on the research phase and expenditures on the development phase. Expenditures on the research phase shall be recognised in profit or loss for the current period when incurred. Expenditures on the development phase will be capitalised only when all of the following conditions are satisfied: it is technically feasible to complete the intangible asset so that it will be available for use or sale; the Company intends to complete the intangible asset and use or sell it; it can be demonstrated how the 193 Joincare Pharmaceutical Group Annual Report 2022 intangible asset will generate economic benefits, including proving that the intangible assets or the products produced by it will have markets, or the intangible assets for internal use will be useful; there are adequate technical, financial and other resources to complete the development and the Company is able to use or sell the intangible assets; and expenditures on the development phase attributable to the intangible assets can be reliably measured. The development expenditures that do not satisfy the above conditions shall be recognised in profit or loss for the current period. Our research and development projects enter the development stage after meeting the above conditions and forming the project through the technical and economic feasibility studies. Capitalised expenditures on the development phase are shown as development expenditures on the balance sheet and reclassified as intangible assets on the date the project meets the intended purpose. Capitalisation conditions for specific research and development projects are as follows: ① For research and development projects that are not required to obtain clinical approvals, the period from the beginning of research and development to the pilot phase is treated as the research phase, and all expenditures shall be recognised in profit or loss for the current period when incurred; the period from the pilot phase to the obtaining of production approvals is treated as the development phase, and all expenditures shall be recognised as development expenditures and reclassified as intangible assets after the obtaining of production approvals. ② For research and development projects that require clinical approval, the period from the beginning of research and development to the obtaining of clinical approval is treated as the research phase, and all expenditures incurred shall be recognised in profit or loss for the current period when incurred; the period from the obtaining of clinical approval to the obtaining of production approval is treated as the development phase, and the expenditures shall be recognised as development expenditures and reclassified as intangible assets after the obtaining of production approval. ③ External technology transfer fees and the cost of purchasing clinical approvals can be recognised directly as development expenditures, and subsequent expenditures are accounted for in accordance with ① and ② above. ④ The Company reviews the latest research and development status of each project at the end of each year and if the research and development project no longer qualifies for the development stage, the corresponding development expenditure are recognised in profit or loss for the current period. ⑤ Where it is impossible to differentiate the expenditures on the research phase and the expenditures on the development phase, all the research and development expenditures are recognised in profit or loss for the current period. Please refer to note III.22 for the impairment testing methodology and impairment provision for intangible assets. 22. Impairment of assets The impairment of subsidiaries, associates and joint ventures in the long-term equity investments, investment properties subsequently measured at cost, fixed assets, construction in progress, right-of-use assets, intangible assets, etc. (Excluding inventories, deferred income tax assets and financial assets) are determined as follows: At the balance sheet date, the Company determines whether there may be evidence of impairment, if there is any, the Company will estimate the recoverable amount for impairment, and then test for impairment. For goodwill arising from a business combination, intangible assets with indefinite useful life and the intangible assets that have not yet ready for use are tested for impairment annually regardless of whether such evidence exists. The recoverable amount of an asset is determined by the higher amount of fair value deducting disposal costs 194 Joincare Pharmaceutical Group Annual Report 2022 and net present value of future cash flows expected from the assets. The Company estimates the recoverable amount based on individual asset; for individual asset which is difficult to estimate the recoverable amount, the recoverable amount of the asset group is determined based on the asset group involving the asset. The identification of the asset group is based on whether the cash flow generated from the asset group is independent of the major cash inflows from other assets or asset groups. When the asset or asset group’s recoverable amount is lower than its carrying amount, the Company reduces its carrying amount to its recoverable amount, the reduced amount is included in profit or loss, while the provision for impairment of assets is recognised. In terms of impairment test of the goodwill, the carrying amount of the goodwill, arising from business combination, shall be allocated to the related asset group in accordance with a reasonable basis at acquisition date. Those that are difficult to be allocated to related assets shall be allocated to related asset group. Related assets or assets group refer to those that can benefit from the synergies of business combination and are not larger than the Company’s recognised reporting segment. When there is an indication that the asset and asset group are prone to impair, the Company should test for impairment for asset and asset group excluding goodwill and calculate the recoverable amount and recognise the impairment loss accordingly. The Company should test for impairment for asset or the asset group including goodwill and compare the asset or asset group’s recoverable amount with its carrying amount, provision for impairment of assets shall be recognised when the recoverable amount of assets is lower than its carrying amount. Once impairment loss is recognised, it cannot be reversed in subsequent accounting periods. 23. Long-term deferred expenses The Company’s long-term deferred expenses measured at cost actually incurred and evenly amortised on straight-line basis over the expected beneficial period. For the long-term deferred expense items that cannot benefit in subsequent accounting period, their amortised value is recognised through profit or loss. 24. Employee compensation (1) The scope of employee compensation Employee compensation are all forms of remuneration and compensation given by the Company in exchange for service rendered by employees or the termination of employment. Employee compensation include short- term employee compensation, post-employment benefits, termination benefits and other long-term employee benefits. Employee compensation include benefits provided to employees’ spouses, children, other dependants, survivors of the deceased employees or to other beneficiaries. According to liquidity, employment compensations are presented separately as “accrued payroll” item and “long-term employment compensation payable” item in the balance sheet. (2) Short-term employee compensation During the accounting period in which the employees render the related services, wages, bonuses, social security contributions (including medical insurance, injury insurance, maternity insurance, etc.) and house funding are recognised as liability and included in the profit or loss for the current period or related asset costs. (3) Post-employment benefits Post-employment benefit plans mainly includes defined contribution plans. Defined contribution plans are post-employment benefit plans under which an enterprise pays fixed contributions into a separate fund and will have no future obligations to pay the contributions. Defined contribution plans include the basic pension insurance, unemployment insurance, etc. The Company shall recognise, in the accounting period in which an employee provides service, the 195 Joincare Pharmaceutical Group Annual Report 2022 contribution payable to a defined contribution plan as a liability, with a corresponding charge to the profit or loss for the current period or the cost of a relevant asset. (4) Termination benefits The liability of employee compensation arising from termination benefits is recognised and included in profit or loss for the current period in the earlier date of the followings: The Company cannot unilaterally withdraw the offer of termination benefits because of an employment termination plan or a curtailment proposal; the Company recognises costs or expenses related to the restructuring that involves the payment of termination benefits. For the implementation of the internal retirement plan for employees, the economic compensation before the official retirement date is a termination benefit. The wage of and social insurance contributions for the internally retired employee which would have incurred from the date on which the employee cease rendering services to the Company to the scheduled retirement date will be included in the profit or loss for the current period. Economic compensation after the official retirement date (such as normal pension) should be treated as post-employment benefits. (5) Other long-term employee benefits When other long-term employee benefits provided to the employees by the Company are satisfied the conditions of a defined contribution plan, those benefits shall be accounted for in accordance with the relevant provisions of the above defined contribution plans. When the benefits are satisfied the conditions of a defined benefit plan, those benefits shall be accounted for in accordance with the relevant provisions of the above defined benefit plans, except that the “change in remeasurement of the net liability or net assets of the defined benefit plans” in the cost of the related employee compensation shall be included in profit or loss for the current period or related asset costs. 25. Provision for liabilities An obligation related to a contingency is recognised as a provision when all of the following conditions are satisfied: (1) The obligation is a present obligation of the Company; (2) It is probable that an outflow of economic benefits will be required to settle the obligation; (3) The amount of the obligation can be measured reliably. Provisions are initially measured at the best estimate of the payment to settle the associated obligations and consider the relevant risk, uncertainty and time value of money. If the impact of time value of money is significant, the best estimate is determined as its present value of future cash outflow. The Company reviews the carrying amount of provisions at the balance sheet date and adjusts the carrying amount to reflect the best estimate. If the expenses for clearing of provisions is fully or partially compensated by a third party, and the compensated amount can be definitely received, it is recognised separately as asset. The compensated amount recognised shall not be greater than the carrying amount of the liability recognised. 26. Share-based payment and equity instruments (1) Accounting treatment of share-based payment Share-based payments are transactions in which equity instruments are granted or liabilities are assumed on the basis of equity instruments in order to obtain services from employees or other parties. Share-based payment is classified into equity-settled share-based payment and cash-settled share-based payment. ① Equity-settled share-based payment 196 Joincare Pharmaceutical Group Annual Report 2022 Equity-settled share-based payment is measured at the fair value of the equity instruments granted to employees. If vesting is conditional upon completion of services in the pending period or fulfilment of performance conditions, at each balance sheet date during the pending period, based on the best estimates of the number of vested equity instruments, the services received for the period are recognised as the costs or expenses on a straight-line basis. Instruments which are vested immediately upon the grant are included in relevant costs or expenses at the fair value of equity instruments on the date of grant and capital reserves are increased accordingly. At each balance sheet date during the pending period, the Company makes the best estimate and revises the number of equity instruments expected to be exercisable based on subsequent information such as changes in the number of exercisable employees obtained from the latest available information. The effect of the above estimates is recognised as the relevant cost or expense in the current period, and capital surplus is adjusted accordingly. For the equity instruments granted under an equity-settled share-based payment for services from other parties, if the fair value of services received from other parties can be measured reliably, the fair value of the equity instruments is measured at the fair value of services from other parties on the grant date; if the fair value of services received from other parties cannot be measured reliably but the fair value of the equity instruments can be measured reliably, the fair value of the equity instruments on the date on which services are received shall be recognised as related costs or expenses, with a corresponding increase in owners' equity. ② Cash-settled share-based payment Cash-settled share-based payments are measured at the fair value of the liabilities (share-based or other equity instrument-based) assumed by the Company. Instruments which are vested immediately upon the grant are included in relevant costs or expenses at the fair value of liabilities assumed by the Company on the date of grant and liabilities are increased accordingly. If vesting is conditional upon completion of services in the pending period or fulfilment of performance conditions, at each balance sheet date during the pending period, based on the best estimates of the vesting situation, the services received for the period are recognised as the costs or expenses and corresponding liabilities at fair value of the liabilities assumed by the Company. At each balance sheet date and settlement date before the relevant liabilities are settled, the fair value of liabilities is re-measured and the resulting changes are included in the profit and loss for the current period. (2) Accounting treatment for amendment and termination of share-based payments When the Company modifies the share-based payment plan, and if such modification increases the fair value of the equity instruments granted, the increase in services received will be recognised accordingly following the increase in fair value of the equity instruments; if such modification increases the number of equity instruments granted, the increase in fair value of the equity instruments is recognised as a corresponding increase in service achieved. The increase in fair value of the equity instruments refers to the difference in fair value on the date of modification before and after the modification in respect of the equity instruments. If the modification reduces the total fair value of the share-based payments or adopts any form that is unfavorable to employees to modify the terms and conditions of the share-based payment plan, accounting treatment will be continued to be conducted in respect of the services received and the modification will be deemed to have never occurred, unless the Company had cancelled part or all of the equity instruments granted. During the pending period, if the equity instruments granted are cancelled (except for failure to meet the non- market conditions of the vesting conditions), the Company will undertake an accelerated vesting in respect of the cancelled equity instruments that had been granted, include the remaining amount that shall be recognised during the pending period in the current profit and loss immediately and recognise capital reserve accordingly. Where employees or other parties are permitted to choose to fulfil non-vesting conditions but have not fulfilled during the pending period, the Company will treat the granted equity instruments as cancelled. (3) Accounting treatment for share-based payments involving the Company and the shareholders or the de facto controller of the Company 197 Joincare Pharmaceutical Group Annual Report 2022 For share-based payment transactions involving the Company and the shareholders or the de facto controller of the Company, the settlement enterprise and the enterprise receiving services (one under the Company while another external to the Company) shall follow the requirements below to conduct accounting treatment in the Company’s consolidated financial statements: ① For settlement enterprises settling through their own equity instruments, such share-based payment transaction will be treated as equity-settled share-based payment; except for this, such share-based payment transaction will be treated as cash-settled share-based payment. Where a settlement enterprise is an investor of an enterprise receiving services, the fair value of the equity instruments on the date of grant or the fair value of the liabilities that shall be assumed are recognised as long-term equity investment in the enterprise receiving services, at the same time, capital reserve (other capital reserve) or liabilities are recognised. ② Where an enterprise receiving services has no settlement obligations or grants its own equity instruments to employees, such share-based payment transaction will be treated as equity-settled share-based payment; where an enterprise receiving services has settlement obligations and grants equity instruments (other than its own) to employees, such share-based payment transaction will be treated as cash-settled share-based payment. For a share-based payment transaction occurring among enterprises under the Company where the enterprise receiving services and the settlement enterprise are not the same enterprise, such share-based payment transaction shall be recognised and measured in each of the respective financial statements of the enterprise receiving services and the settlement enterprise by reference to the above principles. 27. Preferred shares, perpetual bonds and other financial instruments (1) Classification of financial liabilities and equity instruments The Company classifies the financial instrument or its components as financial assets, financial liabilities or equity instruments at the initial recognition based on the contract terms of the issued financial instrument and the economic substance it reflects, instead of only in legal form, and combine the definition of financial assets, financial liabilities and equity instruments. (2) Accounting treatment of preferred shares, perpetual bonds and other financial instruments The financial instruments issued by the Company are initially recognised and measured in accordance with the financial instrument standards; thereafter, interest or dividends are accrued or distributed on each balance sheet date and processed in accordance with relevant specific accounting standards for enterprises. That is, on the basis of the classification of the financial instrument issued, the accounting treatment of interest expenses or dividend distributions of the instrument is determined. For financial instruments classified as equity instruments, interest expenses or dividend distributions are treated as profit distribution of the Company, and repurchases and cancellations are treated as changes in equity; for financial instruments classified as financial liabilities, interest expenses or dividend distributions are in principle treated according to borrowing costs, and gains or losses arising from repurchase or redemption are credited to profit or loss for the current period. The transaction costs such as charges and commissions incurred by the Company when issuing financial instruments, if classified as debt instruments and measured at amortised cost, are included in the initial measurement amount of the issued instrument; if classified as equity instruments, are deducted from equity. 28. Revenue The Company shall recognise revenue when the Company satisfies the performance obligation of the contract, that is, the customer obtains control of relevant goods or services. When the contract contains two or more performance obligations, on the effective date of the contract, the Company allocates the transaction price to each performance obligation based on the percentage of respective 198 Joincare Pharmaceutical Group Annual Report 2022 unit price of a good or service guaranteed by each performance obligation, and the revenue is measured according to the transaction price allocated to each performance obligation. If one of the following conditions is fulfilled, the Company satisfies a performance obligation over time; otherwise, it satisfies a performance obligation at a point in time: ① When the customer simultaneously receives and consumes the benefits provided by the Company when the Company performs its obligations under the contract. ② When the customer is able to control the commodity in progress in the course of performance by the Company under the contract. ③ The product produced by the Company under the contract is irreplaceable and the Company has the right to payment for performance completed to date during the term of the contract. For a performance obligation satisfied over time, the Company shall recognise revenue over time by measuring the process towards complete satisfaction of the performance obligation. When the progress of performance cannot be reasonably determined, if the costs incurred by the Company are expected to be recoverable, the revenue will be recognised to the extent of the costs incurred until the progress of performance can be reasonably determined. For a performance obligation satisfied at a point in time, the Company shall recognise revenue when the customer obtains control of relevant goods or services. When determining whether the customer has obtained control of the goods and services, the Company will consider the following indications: ① The Company has the current right to receive payment for the goods or services, which is when the customers have the current payment obligations for the goods. ② The Company has transferred the legal title of the goods to the client, which is when the client possesses the legal title of the goods. ③ The Company has transferred the physical possession of goods to the customer, which is when the customer obtains physical possession of the goods. ④ The Company has transferred all of the substantial risks and rewards of ownership of the goods to the customer, which is when the client obtains all of the substantial risks and rewards of ownership of the goods to the customer. ⑤ When the customer has accepted the goods or services. ⑥ When other information indicates that the customer has obtained control of the goods. A contract asset represents the Company’s right to consideration in exchange for goods or services that it has transferred to a customer when that right is conditioned on factors other than passage of time, for which the loss allowances for expected credit loss is recognised (see Note III.10(6)). The Company shall present any unconditional (i.e. if only the passage of time is required) rights to consideration separately as a receivable. A contract liability is the Company’s obligation to transfer goods or services to a customer for which the Company has received consideration (or the amount is due) from the customer. The contract assets and liabilities under the same contract shall be shown on a net basis. If the net amount stated in debit balance, it will be presented under the items of “Contract assets” or “Other non-current assets” according to its mobility; If the net amount stated in credit balance, it will be presented under the items of “Contract liabilities” or “Other non-current liabilities” according to its mobility. The Company enters into sales contracts with customers. Revenue from sales is recognised according to the invoiced amount upon the delivery of goods to the designated carrier or purchaser according to the orders received from customers; revenue from export sales is recognised mainly by adopting FOB mode according 199 Joincare Pharmaceutical Group Annual Report 2022 to custom declaration upon making declaration for goods and completing the export procedures. 29. Contract costs Contract costs are either the incremental costs of obtaining a contract with a customer or the costs to fulfil a contract with a customer. Incremental costs of obtaining a contract are those costs that the Company incurs to obtain a contract with a customer that it would not have incurred if the contract had not been obtained e.g. an incremental sales commission. The Company recognises as an asset the incremental costs of obtaining a contract with a customer if it expects to recover those costs. Other costs of obtaining a contract are expensed when incurred. If the costs to fulfil a contract with a customer are not within the scope of inventories or other accounting standards, the Company recognises an asset from the costs incurred to fulfil a contract only if those costs meet all of the following criteria: ① The costs relate directly to an existing contract or to a specifically identifiable anticipated contract, including direct labour, direct materials, allocations of overheads (or similar costs), costs that are explicitly chargeable to the customer and other costs that are incurred only because the Company entered into the contract; ② The costs generate or enhance resources of the Company that will be used in satisfying (or in continuing to satisfy) performance obligations in the future; ③ The costs are expected to be recovered. Assets recognised for the incremental costs of obtaining a contract and assets recognised for the costs to fulfil a contract (the “assets related to contract costs”) are amortised on a systematic basis that is consistent with the transfer to the customer of the goods or services to which the assets relate and recognised in profit or loss for the current period. The Company recognises an impairment loss in profit or loss to the extent that the carrying amount of an asset related to contract costs exceeds: ① Remaining amount of consideration that the Company expects to receive in exchange for the goods or services to which the asset relates; ② The cost estimated to be happened for the transfer of related goods or services. The costs of contract performance recognised as assets, if the amortisation period is less than one year or a normal operating cycle upon the initial recognition, are presented as “Inventories” item, and if the amortisation period is more than one year or a normal operating cycle upon the initial recognition, are presented as “Other non-current assets” item. The contract obtaining costs recognised as assets, if the amortisation period is less than one year or a normal operating cycle upon the initial recognition, are presented as “Other current assets” item, and if the amortisation period is more than one year or a normal operating cycle upon the initial recognition, are presented as “Other non-current assets” item. 30. Government grants A government grant shall be recognised only when the enterprise can comply with the conditions attaching to the grant and the enterprise can receive the grant. If a government grant is in the form of a transfer of a monetary asset, the item is measured at the amount received. If a government grant is in the form of a transfer of a non-monetary asset, the item is measured at fair value, when fair value is not reliably determinable, the item is measured at a nominal amount of RMB1. 200 Joincare Pharmaceutical Group Annual Report 2022 Government grant related to assets represents the government grant received for acquisition and construction of long term assets, or forming long term assets in other ways. Except for these, all are government grant related to income. Regarding to the government grant not clearly defined in the official documents and can form long term assets, the part of government grant which can be referred to the value of the assets is classified as government grant related to assets and the remaining part is government grant related to income. For the government grant that is difficult to distinguish, the entire government grant is classified as government grant related to income. The government grant related to assets is recognised as deferred income and would be transferred to profit or loss in reasonable and systematic manner within the period of use of the relevant assets. The government grant related to income which is used to compensate the relevant costs or losses incurred should be recognised in the profit or loss for the current period; the government grant related to income which is used to compensate the relevant costs or losses for the subsequent period is recognised as deferred income and shall be recognised in profit or loss during the relevant cost or loss confirmation period. Government grants measured in nominal terms are directly included in the profit or loss for the current period. The Company has adopted a consistent approach to the same or similar government grant business. The government grants related to daily activities are recognised as other gains in accordance with the substance of economic business. Government grants that are not related to daily activities are recognised as non-operating income. If the recognised government grants need to be refunded, adjust the carrying amount of assets when the carrying amount of assets is offset at the time of initial recognition; the balance of deferred income is offset against the carrying amount of the balance of deferred income and the excess is recognised in the profit or loss for the current period. Other circumstances, it is directly recognised in the profit or loss for the current period. 31. Deferred tax assets and deferred tax liabilities (1) Current tax At the balance sheet date, for the current tax liabilities (or assets) arising from the current period and the previous period, should be measured by the tax of the estimated payable (returnable) amount which be calculated according to the regulations of the tax law. The amount of the tax payable which is based by the calculation of the current tax expenses, are according to the result measured from the corresponding adjustment of the pre-tax accounting profit of the current period which in accord to the relevant regulations of the tax law. (2) Deferred tax assets and deferred tax liabilities The difference between the carrying amount of an asset or liability and its tax basis, as well as the temporary differences arising from differences between the carrying amount and tax basis of items that are not recognised as assets and liabilities but in accordance with the tax law, can be recognised as deferred tax assets and deferred tax liabilities by adopting the balance sheet liability method. No deferred tax liability is recognised for a temporary difference arising from the initial recognition of goodwill the initial recognition of assets or liabilities due to a transaction other than a business combination, which affects neither accounting profit nor taxable profit (or deductible loss). Besides, no deferred tax assets well be recognised for the taxable temporary differences related to the investments in subsidiaries, associates and joint ventures, if the Company can control the time of the reverse of temporary differences as well as the temporary differences are unlikely to be reversed in the foreseeable future. Except for the above exceptions, the Company recognises all deferred income tax liabilities arising from other taxable temporary differences. The deductible temporary differences the initial recognition of assets or liabilities arising from transactions that are neither a business combination, nor do they affect accounting profits and taxable income (or deductible losses), will not be recognised as related deferred income tax assets. In addition, as for the taxable 201 Joincare Pharmaceutical Group Annual Report 2022 temporary differences associated with investments in subsidiaries, associates and joint ventures, if the Company is able to control the timing of the reversal of the temporary differences, and the temporary differences may not be reversed in the foreseeable future, the related deferred income tax assets will also not be recognised. Except for the above exceptions, the Company recognises a deferred tax asset arising from other deductible temporary differences, to the extent that it is probable that taxable income will be available against which the deductible temporary differences. The Company recognises a deferred tax asset for the carry-forward of deductible losses and tax credits to subsequent periods, to the extent that it is probable that future taxable profits will be available against which deductible losses and tax credits can be utilised. At the balance sheet date, deferred tax assets and deferred tax liabilities are measured at the tax rates that are expected to apply to the period when the asset is realised or the liability is settled in accordance with the provisions of the tax law. At the balance sheet date, the Company reviews the carrying amount of a deferred tax asset. If it is probable that sufficient taxable profits will not be available in future periods to allow the benefit of the deferred tax asset to be utilised, the carrying amount of the deferred tax asset is reduced. Any such reduction in amount is reversed when it becomes probable that sufficient taxable profits will be available. (3) Tax expenses The tax expenses comprise current tax and deferred tax. The rest current tax and deferred tax expenses or revenue should be included into current gains and losses expect for the current tax and the deferred tax related to the transaction and events that be confirmed as other comprehensive income or be directly included in the shareholders’ equity which should be included in other comprehensive income or shareholders’ equity as well as the book value for adjusting the goodwill of the deferred income tax occurs from the business combination. (4) Offset of tax The current tax assets and liabilities of the Company should be listed by the written-off net amount which intend to execute the net amount settlement as well as the assets acquiring and liabilities liquidation at the same time while owns the legal rights of settling the net amount. The deferred tax assets and liabilities of the Company should be listed as written-off net amount when having the legal rights of settling the current tax assets and liabilities by net amount and the deferred tax and liabilities is relevant to the tax which be collected from the same taxpaying bodies by the same tax collection and administration department or is relevant to the different taxpaying bodies but during each period which there is significant reverse of the deferred income assets and liabilities in the future and among which the involved taxpaying bodies intend to settle the current income tax and liabilities by net amount or are at the same time acquire the asset as well as liquidate the liabilities. 32. Leases (1) Identification of leases At the inception of a contract, the Company, as a lessee or lessor, assesses if the customer in a contract has the right to obtain substantially all the economic benefits from use of the identified assets and the right to direct the use of the identified assets in the period of use. The Company would identify that a contract is a lease, or contains a lease if a party of the contract transfers the right to control the use of one or more identified assets for a period of time in exchange for consideration. (2) The Company as the lessee At the inception of a lease, the Company recognises all its leases as the right-of-use assets and lease liabilities, except for the short-term leases and the leases of low-value assets which are treated with a simplified approach. 202 Joincare Pharmaceutical Group Annual Report 2022 For the accounting policies on the right-of-use assets, please refer to Note III. 33. Lease liabilities are initially measured based on the present value of outstanding lease payment at the inception of a lease, discounted using the interest rate implicit in the lease or the incremental borrowing rate. Lease payment include: fixed payments and in-substance fixed payments, less any lease incentives (if there is a lease incentive); variable lease payment that are based on an index or a rate; the exercise price of a purchase option if the lessee is reasonably certain to exercise that option; payments of penalties for terminating the lease option, if the lease term reflects that the lessee will exercise that option; and amounts expected to be payable under the guaranteed residual value provided by the lessee. The Company shall subsequently calculate the interest expenses of lease liabilities over the lease term at the fixed periodic interest rate, and include it into the profit or loss for the current period. Variable lease payments not included in the measurement of lease liabilities are charged to profit or loss in the period in which they actually arise. Short-term lease Short-term lease refers to the lease that the lease term does not exceed 12 months from the inception of a lease, and the lease that includes the option of purchase is not a short-term lease. The Company recognises the amount of lease payments of short-term lease in the cost of the related asset or the profit or loss for the current period, on a straight-line method over each period of the lease term. Leases of low-value assets For the Leases of low-value assets, the Company chooses to adopt the above simplified treatment method in accordance with the specific conditions of each lease. The Company recognised the lease payments for the leases of low-value assets in the relevant asset cost or the profit or loss for the current period on a straight-line basis over each period of the lease term. (3) The Company as the lessor When the Company is the lessor, the lease that substantially transfers all the risks and rewards related to the ownership of assets is recognised as a finance lease, and leases other than finance leases are recognised as operating leases. Finance leases In a financial lease, the Company uses the net investment in leases as the carrying amount of finance lease receivables at the inception of a lease. The net investment in leases is the sum of the unguaranteed residual value and the present value of the outstanding lease payment at the inception of a lease, discounted using the interest rate implicit in the lease. The Company, as the lessor, calculates and recognises the interest income over each period of the lease term at a fixed periodic interest rate. Variable lease payments not included in the measurement of the lease liability, which are obtained by the Company as a lessor, are recognised in profit or loss as incurred. The termination of recognition and impairment of financial lease receivables is accounted for in accordance with the provisions of “Accounting Standards for Business Enterprises No. 22 – Recognition and Measurement of Financial Instrument” and “Accounting Standards for Business Enterprises No. 23 – Transfer of Financial Assets”. Operating leases For the rental of operating leases, the Company recognises it in the profit or loss for the current period on a straight- line basis over each period of the lease term. The initial direct cost incurred in connection with an operating lease shall be capitalised and amortised on the same basis for recognition of rental income during the lease term, and shall be included in instalments in the profit or loss for the current period. The variable lease payment, which is obtained in connection with an operating lease and not included in the lease receivables, shall be included in the profit and loss for the current period when they actually occur. 203 Joincare Pharmaceutical Group Annual Report 2022 33. Right-of-use assets (1) Recognition condition of right-of-use assets The right-of-use assets of the Company are defined as the right of underlying assets in the lease term for the Company as a lessee. Right-of-use assets are initially measured at cost as at the commencement date of the lease, which consists of: the amount of the initial measurement of the lease liability; any lease payments made at or before the commencement date of the lease less any lease incentives received if any; initial direct expenses incurred by the Company as a lessee; costs to be incurred by the Company as a lessee in dismantling and removing a leased asset, restoring the site on which it is located or restoring the leased assets to the condition required by the terms and conditions of the lease. The Company as a lessee recognises and measures the costs of demolition and restoration according to “Accounting Standards for Business Enterprises No.13 – Contingencies”, and subsequently adjusts for any remeasurement of lease liability. (2) Depreciation method of right-of-use assets The Company calculates depreciation on a straight-line basis. Right-of-use assets in which the Company as a lessee is reasonably certain to obtain ownership of the underlying leased assets at the end of the lease term are depreciated over the remaining useful life. Otherwise, right-of-use assets are depreciated over the shorter of the lease term and its remaining useful life. (3) For methods of impairment testing and provision for impairment for right-of-use assets, please refer to note III. 22. 34. Repurchase of shares Prior to cancellation or transfer of shares repurchased, the Company recognises all expenditures arising from share repurchase as cost of treasury shares in the treasury share account. Considerations and transaction fee incurred from the repurchase of shares shall lead to the elimination of owners’ equity and does not recognise profit or loss when shares of the Company are repurchased, transferred or cancelled. The difference between the actual amount received and the carrying amount of the treasury stock are recognised as capital reserve when the treasury stocks are transferred, if the capital reserve is not sufficient to be offset, the excess amount shall be recognised to offset surplus reserve and undistributed profit. When the treasury stocks are cancelled, the capital shall be eliminated according to the number of shares and par value of cancellation shares, the difference between the actual amount received and the carrying amount of the treasury stock are recognised as capital reserve, if the capital reserve is not sufficient to be offset, the excess amount shall be recognised to offset surplus reserve and undistributed profit. 35. Restricted shares If the Company grants the restricted shares to incentive participants under the Share Options Incentive Scheme, the incentive participants subscribe for the shares first. If the unlocking conditions stipulated in the Share Options Incentive Scheme cannot be fulfilled subsequently, the Company repurchases the shares at the predetermined price. If the registration and other capital increase procedures for the restricted shares issued to employees are completed in accordance with relevant regulations, the Company recognises share capital and capital reserve (or capital premium) based on the subscription money received from the employees on the grant date; and recognises treasury shares and other payables for repurchase obligation. 36. Significant accounting judgements and estimates Significant accounting estimates and critical assumptions adopted by the Company are continually evaluated based on historical experience and other factors, including expectations of future events that are believed to be reasonable. The significant accounting estimates and critical assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities within the next accounting year are set out below: 204 Joincare Pharmaceutical Group Annual Report 2022 (1) Classification of financial assets Significant judgements involved in determining the classification of financial assets include analysis of business mode and characteristics of the contractual cash flows. Factors considered by the Company in determining the business model of financial assets management for a group of financial assets include past experience on how financial asset’s performance is evaluated and reported to key management personnel, how risks affecting the performance of financial asset are assessed and managed and how managers of related businesses are compensated. When assessing whether the contractual cash flows of financial assets are consistent with basic lending arrangement, the Company adopts the following significant judgements: whether the time distribution or amounts of the principal within the duration may change due to early repayment and other reasons; whether the interest includes only the time value of money, credit risk, other basic lending risks and the consideration for cost and profit. For example, the amounts of early repayment only reflect principal unpaid, the interest based on principal unpaid and reasonable compensation paid for early termination of a contract. (2) Measurement of ECL for accounts receivables The Company calculates ECL of accounts receivables according to their exposure at default and ECL rate, and determines ECL rate based on probability of default and loss given default. When determining ECL rate, the Company adopts data like historical credit loss experience in combination with current situation and forward-looking information to adjust historical data. When considering forward-looking information, the Company uses indicators including the risk of economic downturn, external market environment, technology environment and changes on customer situation. The Company periodically monitors and reviews assumptions relevant to the measurement of ECL. (3) Impairment of non-current assets other than financial assets (other than goodwill) The Company determines at the balance sheet date whether there are signs of possible impairment of non- current assets other than financial assets. For intangible assets that have not yet reached usable condition, in addition to the annual impairment test, when there are signs of impairment, the impairment test is also carried out. Other non-current assets, other than financial assets, are tested for impairment when there are indications that their carrying amount is not recoverable. An impairment occurs when the carrying amount of an asset or group of assets is higher than the recoverable amount, which is the present value of the fair value net of disposal costs and projected future cash flows. The net amount of fair value less disposal costs, is determined by referencing to the agreed sale price or observable market value of a similar asset in an arm's length transaction, less incremental costs directly attributable to the disposal of that asset. When projecting the present value of future cash flows, management must estimate the projected future cash flows of the asset or group of assets and select an appropriate discount rate to determine the present value of future cash flows. (4) Impairment of goodwill The Company evaluates whether goodwill is impaired at least once a year. This requires an estimate of the value in use of the asset groups to which the goodwill is allocated. In estimating the value in use, the Company needs to estimate the future cash flows generated from the asset groups and also to choose an appropriate discount rate in order to calculate the present value of the future cash flows. (5) Development costs Determining the amounts to be capitalised requires the management to make assumptions regarding the expected future cash flows generated from the relevant assets, discount rates to be applied and the expected period of benefits. (6) Deferred tax assets The deferred income tax assets will be recognised for all unused tax losses to the extent that it is probable that there will be sufficient taxable profits against which the loss is utilised. This requires the management to 205 Joincare Pharmaceutical Group Annual Report 2022 exert numerous judgments to estimate the timing and amount of the future taxable profits so as to determine the amount of deferred income tax assets to be recognised with reference to the tax planning strategy. (7) Revenue recognition As stated in note III. 28, the Company makes the following significant accounting judgements and estimates in terms of revenue recognition: identifying customer contracts; estimating the recoverability of the considerations that are entitled to be obtained by transferring goods to customers; identifying the performance obligation in the contract; estimating the variable consideration in the contract and cumulative revenue recognised where it is highly probable that a significant reversal therein will not occur when the relevant uncertainty is resolved; assessing whether there is a significant financing component in the contract; estimating the individual selling price of the individual performance obligation in the contract, etc. The Company makes judgments primarily based on historical experiences and works. Changes in these significant judgments and estimates may have significant impacts on the operating income, operating costs, and profit or loss of the current or subsequent periods. (8) Determination of the fair value of unlisted equity investment The fair value of unlisted equity investments represents the expected future cash flows discounted at the prevailing discount rate of items with similar terms and risk characteristics. It requires the Company to estimate the expected future cash flows and discount rates, and therefore there is uncertainty. Under limited circumstances, if the information used to determine the fair value is insufficient, or the possible estimated amount of fair value is widely distributed, and cost represents the best estimate of the fair value within such scope, the cost may represent an appropriate estimate of the fair value within such distribution scope. 37. Changes in significant accounting policies and accounting estimates and correction to accounting errors (1) Changes in significant accounting policies ① Interpretation No. 15 of Accounting Standards for Business Enterprises The Ministry of Finance issued the Interpretation No. 15 of Accounting Standards for Business Enterprises (Cai Kuai [2021] No. 35, hereinafter referred to as “Interpretation No. 15”) in December 2021. Interpretation No. 15 stipulates that when the Company sells the products or by-products produced before the fixed assets reach the status of intended use or during the research and development process (hereinafter collectively referred to as “revenue in trial operation”), in accordance with the “Accounting Standards for Business Enterprises No. 14 - Revenue", "Accounting Standards for Business Enterprises No. 1 - Inventories" and other regulations, the revenue and costs relevant to the trial operation shall be accounted for separately and included in the profit or loss for the current period, rather than the net amount of sale revenue after offsetting relevant costs of the trial operation sales write-off against the cost of fixed assets or research and development expenditures. When the relevant products or by-products produced by the trial operation are sold externally, those that meet the requirements of the "Accounting Standards for Business Enterprises No. 1 - Inventory" should be recognized as inventories, and those that meet the relevant asset recognition conditions in other relevant Accounting Standards for Business Enterprises should be recognized as related assets. The Company implemented Interpretation No. 15 “Accounting treatment for the sale of products or by- products produced by the enterprise before the fixed assets reach the intended usable state or during the research and development process” from 1 January 2022. Interpretation No. 15 stipulates that in onerous contracts, "costs that will inevitably occur in performing contractual obligations" should reflect the minimum net cost of exiting the contract, i.e. the lower of the cost of performing the contract and the compensation or penalty for failure to perform the contract. The cost for the Company to perform the contract includes the incremental cost of performing the contract and the apportioned amount of other costs directly related to the performance of the contract, of which the incremental cost of fulfilling the contract includes direct labor, direct materials, etc.; the apportioned amount of other costs directly related to the performance of the contract includes the apportioned amount of the 206 Joincare Pharmaceutical Group Annual Report 2022 depreciation expense of the fixed assets used to perform the contract. The Company implemented Interpretation No. 15 “Judgment on Onerous Contracts” from 1 January 2022. The adoption of Interpretation No. 15 did not have any significant impact on the financial position and operating results of the Company. ② Interpretation No. 16 of Accounting Standards for Business Enterprises The Ministry of Finance issued the Interpretation No. 16 of Accounting Standards for Business Enterprises (Cai Kuai [2022] No. 31, hereinafter referred to as “Interpretation No. 16”) in November 2022. Interpretation No. 16 stipulates that for financial instruments such as perpetual bonds classified as equity instruments, the Company shall recognize the income tax impact related to dividends when confirming dividends payable. For the distributed profit comes from the transaction or event that generated profit or loss in the past, the income tax effect of the dividend should be included in the profit or loss for the current period; For the profit distributed from the transactions or event previously recognized in the owner’s equity, the income tax effect of the dividend should be included in the owner’s equity item. Interpretation No. 16 stipulates that if the Company modifies the terms and conditions of a cash-settled share- based payment agreement to make it an equity-settled share-based payment, on the date of modification, the Company shall measure the equity-settled share-based payment according to the fair value of the equity instrument granted on the day, include the services obtained in the capital reserve, and at the same time derecognize the liabilities of the cash-settled share-based payment recognized on the date of modification, the difference between the two is included in the profit or loss for the current period. If the vesting period is extended or shortened due to the revision, the Company shall perform the above accounting treatment according to the revised vesting period (without considering the relevant accounting treatment provisions of adverse revisions). The adoption of Interpretation No. 16 did not have any significant impact on the financial position and operating results of the Company. (2) Changes in significant accounting estimates None. IV. Taxation 1. Major taxes and their tax rates Tax category Tax basis Statutory tax rate % Value-added tax Taxable revenue 3, 6, 13 Urban maintenance and construction tax Turnover tax paid 1, 5, 7 Education surcharge Turnover tax paid 3 Local education surcharge Turnover tax paid Note 1 Enterprise income tax Taxable profit Note 2 Note 1. The Company and its subsidiaries that are incorporated in Shenzhen and Zhuhai shall pay local education surcharges that are charged as 2% of the turnover tax payable. Other subsidiaries shall pay local education surcharges according to the tax rate as specified at their places of incorporation on the basis of turnover tax payable. Note 2. Enterprise income tax rate implementation is as follows: 207 Joincare Pharmaceutical Group Annual Report 2022 Entity Income tax rate % Hong Kong Health Pharmaceutical Industry Company Limited (香港健康药业有限公 司), Livzon Pharmaceutical Biotechnology Co., Ltd. (丽珠医药生物科技有限公司), 16.5 Lian (Hong Kong) Co., Ltd. (丽安香港有限公司), Livzon Biologics Hong Kong Limited (丽珠生物科技香港有限公司) 0 or 12 (Tax rate is 12% where the taxable income is MOP600,000 or more; for Companhia de Macau Carason Limitada (澳门嘉安信有限公司), Li Zhu (Macau) those with taxable income Limitada (丽珠(澳门) 有限公司) less than MOP600,000, they are exempted from income taxes.) The Company and Shenzhen Taitai Pharmaceutical Industry Co., Ltd. (深圳太太药业 有限公司), Shenzhen Haibin Pharmaceutical Co., Ltd. (深圳市海滨制药有限公司), Xinxiang Haibin Pharmaceutical Co., Ltd. (新乡海滨药业有限公司), Jiaozuo Joincare Bio Technological Co., Ltd. (焦作健康元生物制品有限公司), Shanghai Frontier Health Pharmaceutical Technology Co., Ltd. (上海方予健康医药科技有限 公司), Guangzhou Joincare Respiratory Medicine Engineering Technology Co., Ltd. (广州健康元呼吸药物工程技术有限公司), Joincare Haibin Pharmaceutical Co., Ltd. (健康元海滨药业有限公司);Livzon Group and subsidiaries of Livzon Group, Livzon Group Limin Pharmaceutical Manufacturing Factory (丽珠集团利民制药厂) . Livzon Group Livzon Pharmaceutical Manufacturing Factory (丽珠集团丽珠制药厂) . Zhuhai FTZ Livzon Hecheng Pharmaceutical Manufacturing Co., Ltd. (珠海保税区丽 15 珠合成制药有限公司), Shanghai Livzon Pharmaceutical Manufacturing Co., Ltd. (上 海丽珠制药有限公司), Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc. (丽珠集团新北江制药股份有限公司). Sichuan Guangda Pharmaceutical Manufacturing Co., Ltd. (四川光大制药有限公司), Zhuhai Livzon Diagnostics Inc. (珠海丽珠试剂股份有限公司), Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd. (丽珠集团福州福兴医药有限公司), Shanghai Livzon Biotechnology Co., Ltd. (上海丽珠生物科技有限公司), Livzon Group (Ningxia) Pharmaceutical Manufacturing Co., Ltd. (丽珠集团(宁夏) 制药有限公司), Livzon MABPharm Inc. (珠海市丽珠单抗生物技术有限公司), Zhuhai Lihe Medical Diagnostic Products Co., Ltd. (珠海丽禾医疗诊断产品有限公司), Zhuhai Livzon Chinese Medicine Modern Technology Co., Ltd. (珠海市丽珠中药现代化科技有限公司) Livzon MAB Pharm (US) Inc. (丽珠单抗生物技术(美国) 有限公司) 21 17 or 24 (registered capital of less than MYR 2.5 million, the tax rate is 17% on the first profit less than MYR LIVZON BIOLOGICS (MALAYSIA) SDN. BHD. 600,000; the registered capital exceeds MYR 2.5 million or the profit exceeds MYR 600,000, the tax rate is 24%) Health Investment Holdings Ltd, Joincare Pharmaceutical Group Industry Co.,Ltd., Livzon International Ventures, Livzon International Ventures I, 0 (Note1) Livzon International Ventures II Other subsidiaries 25 Note 1. Companies registered in the British Virgin Islands and the Cayman Islands are not subject to enterprise income tax. 2. Tax incentives and approval documents (1) Preferential value added tax In accordance with the Announcement on Value Added Tax on Biological Products Sold by Pharmaceutical Operation Enterprises issued by the State Administration of Taxation (Announcement of State Administration of Taxation 2012 No. 20) and the Notice of the Ministry of Finance, the General Administration of Customs, 208 Joincare Pharmaceutical Group Annual Report 2022 the State Administration of Taxation and the State Drug Administration on the Value-Added Tax Policies for Anti-Cancer Drugs (Caishui [2018] No. 47), the biological products sold by the Company are subject to value added tax at 3% by the simple approach. (2) Preferential enterprise income tax The Company enjoys the preferential income tax policy for high-tech enterprises for the 3 years from 2022; The Company's subsidiaries, Shenzhen Taitai Pharmaceutical Co., Ltd. (深圳太太药业有限公司), Shenzhen Haibin Pharmaceutical Co., Ltd (深圳市海滨制药有限公司), Xinxiang Haibin Pharmaceutical Co., Ltd. (新 乡海滨药业有限公司) and Shanghai Frontier Health Medicine Technology Co., Ltd. (上海方予健康医药 科技有限公司) are entitled to enjoy preferential income tax policies applicable to high and new technology enterprises for 3 years with effective from 2020. Joincare Haibin Pharmaceutical Co., Ltd. (健康元海滨药 业有限公司) entitled to enjoy preferential income tax policies applicable to high and new technology enterprises for 3 years with effective from 2020. Jiaozuo Joincare Bio Technological Co., Ltd. (焦作健康元 生物制品有限公司), Guangzhou Joincare Respiratory Drug Engineering Technology Co., Ltd. (广州健康 元呼吸药物工程技术有限公司) have re-applied for high-tech enterprise certification in this period. Livzon Group and its subsidiaries— Livzon Group Limin Pharmaceutical Manufacturing Factory (丽珠集团利民 制药厂), Livzon Group Livzon Pharmaceutical Factory (丽珠集团丽珠制药厂), Zhuhai FTZ Livzon Hecheng Pharmaceutical Manufacturing Co., Ltd. (珠海保税区丽珠合成制药有限公司), Shanghai Livzon Pharmaceutical Manufacturing Co., Ltd. ( 上 海 丽 珠 制 药 有 限 公 司 ), Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd. (丽珠集团福州福兴医药有限公司 ) and Sichuan Guangda Pharmaceutical Manufacturing Co., Ltd. (四川光大制药有限公司) are entitled to enjoy preferential income tax policies applicable to high and new technology enterprises for 3 years with effective from 2020. Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc. (丽珠集团新北江制药股份有限公司), Zhuhai Livzon Diagnostics Inc. (珠海丽珠试剂股份有限公司) and Livzon MABPharm Inc. (珠海市丽珠单抗生物技术 有限公司) have re-applied for high-tech enterprise certification in this period, and has been announced to be identified as a high-tech enterprise. Shanghai Livzon Biotechnology Co., Ltd. (上海丽珠生物科技有限公 司) are entitled to preferential income tax policies applicable to high and new technology enterprises for 3 years with effective from 2021. Livzon Group (Ningxia) Pharmaceutical Manufacturing Co., Ltd. (丽珠集 团(宁夏) 制药有限公司) was approved to enjoy the enterprise taxation preference of the Encouraged Industries in Western China. The above companies were subject to enterprise income tax rate of 15% for the period. In accordance with Article 27 of the Enterprise Income Tax Law of the People's Republic of China and Article 86 of the Regulations for the Implementation of the Enterprise Income Tax Law of the People's Republic of China, the business of planting Chinese herbal medicines engaged by the subsidiaries of the Livzon, Datong Livzon Qiyuan Medicine Co., Ltd. (大同丽珠芪源药材有限公司) and Longxi Livzon Shenyuan Medicine Co., Ltd. (陇西丽珠参源药材有限公司) are exempted from enterprise income tax. According to the "Notice of the Ministry of Finance and the State Administration of Taxation on the Preferential Policies for Enterprise Income Tax in the Hengqin Guangdong-Macao Deep Cooperation Zone" (Cai Shui [2022] No. 19), enterprise income tax is levied at a reduced rate of 15% for qualified industrial enterprises located in the Hengqin Guangdong-Macao Deep Cooperation Zone. The Livzon Grou’s subsidiaries, Zhuhai Lihe Medical Diagnostic Products Co., Ltd. (珠海丽禾医疗诊断产品有限公司) and Zhuhai Livzon Chinese Medicine Modern Technology Co., Ltd. (珠海市丽珠中药现代化科技有限公司) meet the relevant conditions and are subjected to 15% enterprise income tax rate for the current period. According to the preferential tax policies for small low-profit enterprises, the portion of annual taxable income of a small low profit enterprise which does not exceed RMB1 million is subject to enterprise income tax at a tax rate of 2.5%; the portion over RMB1 million but not exceeding RMB3 million is subject to enterprise income tax at a tax rate of 5%. V. Notes to the items of consolidated financial statements 1. Cash and bank balances 209 Joincare Pharmaceutical Group Annual Report 2022 Item 2022.12.31 2021.12.31 Cash on hand 231,883.95 225,179.98 Cash at bank 14,792,867,005.08 11,554,754,721.43 Other monetary funds 15,389,221.93 174,250,489.57 Total 14,808,488,110.96 11,729,230,390.98 Including: Total amount of money deposited 1,491,900,539.35 1,309,853,620.27 abroad ① Other monetary funds are mainly deposits for investments, deposits under guarantee of letter of guarantee, issuing letters of credit and foreign exchange forward contracts, etc. ② Restricted funds relating to issuing letters of credit, bank acceptance bills and foreign exchange forward contracts, etc. in other monetary funds were deducted from cash and cash equivalents in the cash flow statement. Apart from these restricted funds, there is no other charge, pledge or lock up on the cash at bank balance that may limit its use, is kept outside China and may have probable risks in its collection. Below are the details of the use of restricted monetary funds: Item 2022.12.31 2021.12.31 Deposits for letter of credit 444,032.37 1,788,607.74 Deposits for bank acceptance bills 947,255.39 6,004,457.37 Deposits for other business 1,120.00 3,949,531.92 Total 1,392,407.76 11,742,597.03 2. Financial assets held for trading (1) Classification Item 2022.12.31 2021.12.31 Financial assets held for trading 109,015,664.98 184,638,344.31 Including: Debt instruments investment 934,289.94 940,162.94 Equity instruments investment 102,648,863.47 176,321,853.05 Derivative financial assets 5,432,511.57 7,376,328.32 Total 109,015,664.98 184,638,344.31 ① The Company's investments in equity instruments and debt instruments for financial assets held for trading at period end were listed for trading on Shenzhen Stock Exchange, Hong Kong Stock Exchange and NASQAQ. The fair value was determined based on the closing price on the last trading day in the Reporting Period. ② Derivative financial assets represent foreign currency forward contracts, futures contracts and gains from unexpired contracts measured at fair value which were recognised as financial assets as at the balance sheet date. (2) No restrictive financial asset measured at fair value through profit or loss was included in the closing balance. (3) No hedging instruments in the closing balance and no hedging transactions have occurred during the period. 3. Notes receivable 210 Joincare Pharmaceutical Group Annual Report 2022 2022.12.31 2021.12.31 Category Provision Provision Book balance for bad Carrying amount Book balance for bad Carrying amount debts debts Bank acceptance 1,959,985,016.85 0.00 1,959,985,016.85 1,977,767,022.02 481,000.00 1,977,286,022.02 bills (1) Notes receivable pledged at year end Category Amount pledged at year end Bank acceptance bills 469,659,266.19 As at 31 December 2022, bank acceptance bills with carrying amount of RMB469,659,266.19 (31 December 2021: RMB870,153,979.75) have been used as pledge for opening of bills. (2) Bills endorsed or discounted to other parties but not yet expired at balance sheet date Amount derecognized at Amount not derecognized at year Category year end end Bank acceptance bills not yet mature but 542,620,475.62 0.00 already endorsed Bank acceptance bills not yet mature but 422,899,944.56 0.00 already discounted Total 965,520,420.18 0.00 In the current period, the Company discounted bank acceptance bills of RMB1,089,259,970 (previous year: RMB76,908,320). Since the major risks and rewards such as interest rate risk related to these bank acceptance bills have been transferred to the bank, the Company derecognizes the discounted unexpired bank acceptance bills. Factoring expenses incurred was RMB6,363,470 (previous year: RMB506,780). (3) There was no bills transferred into account receivables for non-performance by the issuer at balance sheet date of the period (4) Disclosure by method of provision for bad debts 2022.12.31 2021.12.31 Category Book balance Provision for bad debts Book balance Provision for bad debts Expected Carrying value Expected Carrying value Ratio Amount Amount credit loss Amount Ratio (%) Amount credit loss (%) rate (%) rate (%) Provision for bad debts on 0.00 0.00 0.00 0.00 0.00 481,000.00 0.02 481,000.00 100.00 0.00 individual item Including: Bank acceptance 0.00 0.00 0.00 0.00 0.00 481,000.00 0.02 481,000.00 100.00 0.00 bills Provision for bad debts on 1,959,985,016.85 100.00 0.00 0.00 1,959,985,016.85 1,977,286,022.02 99.98 0.00 0.00 1,977,286,022.02 portfolio basis Including: Bank acceptance 1,959,985,016.85 100.00 0.00 0.00 1,959,985,016.85 1,977,286,022.02 99.98 0.00 0.00 1,977,286,022.02 bills Total 1,959,985,016.85 100.00 0.00 0.00 1,959,985,016.85 1,977,767,022.02 100.00 481,000.00 0.02 1,977,286,022.02 (5) Provision for bad debts on individual item: 211 Joincare Pharmaceutical Group Annual Report 2022 2022.12.31 2021.12.31 Name Provision Expected Provision Expected Book Reason of Book Reason of for bad credit loss for bad credit loss balance provision balance provision debts rate (%) debts rate (%) Henan Jiuzhoutong Expected to be 0.00 0.00 0.00 431,000.00 431,000.00 100.00 Pharmaceutical uncollectible Co., Ltd. Expected to be Other customers 0.00 0.00 0.00 50,000.00 50,000.00 100.00 uncollectible Total 0.00 0.00 0.00 481,000.00 481,000.00 100.00 (6) Accrual, recovery or reversal of bad debt provision during the year Item Amount of provision for bad debts Beginning balance 481,000.00 Provision for the year 0.00 Recovered or reversal in the 0.00 year Write-off in the year 481,000.00 Closing balance 0.00 (7) Actual write-off of notes receivable during the year Item Written-off amount Actual write-off of notes receivable 481,000.00 4. Accounts receivable (1) Disclosure by ageing Ageing 2022.12.31 2021.12.31 Within one year 3,120,189,972.55 2,872,710,981.81 1 to 2 years (inclusive of 2 years) 23,444,432.08 18,541,236.06 2 to 3 years (inclusive of 3 years) 3,734,160.84 12,869,985.75 3 to 4 years (inclusive of 4 years) 12,774,996.94 7,835,031.26 4 to 5 years (inclusive of 5 years) 2,294,804.48 1,332,259.38 Over 5 years 13,796,669.97 12,807,886.92 Subtotal 3,176,235,036.86 2,926,097,381.18 Less: Provision for bad debts 72,476,186.71 72,441,829.64 Total 3,103,758,850.15 2,853,655,551.54 According to the credit policy of the Company, the Company usually grants a credit period ranging from 30 to 90 days to its customers. (2) Disclosure by method of provision for bad debts 2022.12.31 2021.12.31 Book balance Provision for bad debts Book balance Provision for bad debts Category Expected Expected Carrying value Carrying value Ratio Ratio credit Amount Amount credit loss Amount Amount (%) (%) loss rate rate (%) (%) Provision for 10,454,599.67 0.33 6,257,914.47 59.86 4,196,685.20 9,709,854.02 0.33 5,513,168.82 56.78 4,196,685.20 bad debts on 212 Joincare Pharmaceutical Group Annual Report 2022 individual item Including: Receivables from domestic 10,454,599.67 0.33 6,257,914.47 59.86 4,196,685.20 9,709,854.02 0.33 5,513,168.82 56.78 4,196,685.20 customers Receivables from overseas 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 customers Provision for bad debts on 3,165,780,437.19 99.67 66,218,272.24 2.09 3,099,562,164.95 2,916,387,527.16 99.67 66,928,660.82 2.29 2,849,458,866.34 portfolio basis Including: Receivables from domestic 2,659,276,844.47 83.72 60,180,304.43 2.26 2,599,096,540.04 2,333,938,533.50 79.76 58,705,544.56 2.52 2,275,232,988.94 customers Receivables from overseas 506,503,592.72 15.95 6,037,967.81 1.19 500,465,624.91 582,448,993.66 19.91 8,223,116.26 1.41 574,225,877.40 customers Total 3,176,235,036.86 100.00 72,476,186.71 2.28 3,103,758,850.15 2,926,097,381.18 100.00 72,441,829.64 2.48 2,853,655,551.54 Provision for bad debts on individual item: Closing balance Name Provision for Expected credit Book balance Reason of provision bad debts loss rate (%) Full amount is unlikely to be Purchase of goods 10,454,599.67 6,257,914.47 59.86 recovered Provision for bad debts on portfolio basis: Provision for bad debts on portfolio basis: Receivables from domestic customers 2022.12.31 2021.12.31 Ageing Expected Accounts Provision for Accounts Provision for Expected credit credit loss receivable bad debts receivable bad debts loss rate (%) rate (%) Within one year 2,618,111,979.83 35,631,686.09 1.36 2,290,261,988.15 32,953,674.70 1.44 1 to 2 years (inclusive 18,418,832.08 3,486,917.81 18.93 18,541,236.06 2,450,973.15 13.22 of 2 years) 2 to 3 years (inclusive 3,589,415.19 2,144,629.72 59.75 4,476,615.34 2,960,042.15 66.12 of 3 years) 3 to 4 years (inclusive 4,381,626.53 4,171,620.14 95.21 7,550,258.06 7,277,583.42 96.39 of 4 years) 4 to 5 years (inclusive 1,667,403.89 1,637,863.72 98.23 1,271,992.78 1,226,828.03 96.45 of 5 years) Over 5 years 13,107,586.95 13,107,586.95 100.00 11,836,443.11 11,836,443.11 100.00 Total 2,659,276,844.47 60,180,304.43 2.26 2,333,938,533.50 58,705,544.56 2.52 Provision for bad debts on portfolio basis: Receivables from overseas customers 2022.12.31 2021.12.31 Ageing Expected Accounts Provision for Expected credit Accounts Provision for bad credit loss receivable bad debts loss rate (%) receivable debts rate (%) Within one year 506,503,592.72 6,037,967.81 1.19 582,448,993.66 8,223,116.26 1.41 Total 506,503,592.72 6,037,967.81 1.19 582,448,993.66 8,223,116.26 1.41 (3) Accrual, recovery or reversal of bad debt provision during the year Item Amount of provision for bad debts Beginning balance 72,441,829.64 213 Joincare Pharmaceutical Group Annual Report 2022 Provision for the year 2,978,050.82 Recovered or reversal in the year 0.00 Write-off in the year 2,971,670.00 Others 27,976.25 Closing balance 72,476,186.71 At 31 December 2022 and 31 December 2021, the Company had no overdue but not impaired accounts receivable. (4) Accounts receivable written-off during the year Item Written-off amount Actual written-off of accounts receivable 2,971,670.00 (5) Accounts receivable due from the top five debtors As of 31 December 2022, the total amount of the top five debtors in closing balance is RMB380,564,636.45, accounting for 11.98% of the total amount of closing balance of accounts receivable, and the corresponding closing balance of provision for bad debts is total RMB3,048,053.17. (6) There were no accounts receivable derecognized due to the transfer of financial assets in each reporting period. (7) There were no assets or liabilities formed by the continuing involvement of transferred accounts receivables in each reporting period. 5. Prepayments (1) Prepayments by ageing 2022.12.31 2021.12.31 Ageing Amount Ratio % Amount Ratio % Within one year 343,457,382.98 94.29 354,340,559.20 95.97 1 to 2 years 16,867,695.41 4.63 8,031,100.50 2.17 2 to 3 years 948,519.54 0.26 6,323,201.42 1.71 Over 3 years 2,991,544.64 0.82 537,685.17 0.15 Total 364,265,142.57 100.00 369,232,546.29 100.00 (2) Prepayments due from the top five debtors: As of 31 December 2022, the total amount of the top five prepayments in closing balance is RMB127,433,641.24, accounting for 34.98% of the total amount of closing balance of prepayments. 6. Other receivables Item 2022.12.31 2021.12.31 Interest receivable 0.00 365,873.64 Other receivables 52,535,740.14 87,687,951.48 Total 52,535,740.14 88,053,825.12 (1) Other receivables ① by ageing 214 Joincare Pharmaceutical Group Annual Report 2022 Ageing 2022.12.31 2021.12.31 Within one year 46,704,835.62 53,953,012.32 1 to 2 years 6,086,106.11 33,803,432.35 2 to 3 years 2,206,852.09 1,821,553.83 3 to 4 years 1,821,553.83 2,532,015.23 4 to 5 years 1,816,535.04 807,025.60 Over 5 years 32,171,819.98 50,248,098.81 Subtotal 90,807,702.67 143,165,138.14 Less: Provision for bad debts 38,271,962.53 55,477,186.66 Total 52,535,740.14 87,687,951.48 ② Disclosure by nature 2022.12.31 2021.12.31 Item Provision for Carrying Provision for Carrying Book balance Book balance bad debts amount bad debts amount Security deposits, 11,003,281.04 2,897,272.69 8,106,008.35 12,668,692.36 3,613,600.49 9,055,091.87 deposits and rental fees Reserved fund 17,870,245.40 2,259,346.33 15,610,899.07 25,494,468.62 2,952,756.24 22,541,712.38 and advances Related party 20,328,583.96 19,068,538.71 1,260,045.25 1,097,855.07 477,066.07 620,789.00 balances External entities 13,226,352.58 11,966,700.69 1,259,651.89 22,417,100.76 11,924,828.60 10,492,272.16 balances Tax refund on 17,708,111.60 198,927.69 17,509,183.91 16,539,609.68 290,344.77 16,249,264.91 exports Treasury bonds and 17,968,386.04 17,968,386.04 0.00 17,968,386.04 17,968,386.04 0.00 security deposits Capital 24,078,925.22 0.00 24,078,925.22 0.00 0.00 0.00 reduction Amounts of exercised 0.00 0.00 0.00 8,463,240.98 0.00 8,463,240.98 options Others 3,812,338.32 1,003,108.23 2,809,230.09 3,327,263.14 1,159,886.60 2,167,376.54 Total 90,807,702.67 38,271,962.53 52,535,740.14 143,165,138.14 55,477,186.66 87,687,951.48 ③Information of provision for bad debts At 31 December 2022, there is no provision for bad debts on those in first stage. At year end, provision for bad debts on those in second stage: Expected credit Provision for bad Carrying Category Book balance loss rate for the Reason debts amount lifetime(%) Provision for bad debts on 0.00 0.00 0.00 0.00 -- individual item Provision for bad debts on 62,329,598.16 15.71 9,793,858.02 52,535,740.14 portfolio basis Export tax refund receivable 16,539,609.68 1.76 290,344.77 16,249,264.91 Security deposits, deposits 12,668,692.36 28.52 3,613,600.49 9,055,091.87 215 Joincare Pharmaceutical Group Annual Report 2022 and rental receivable Other receivables 33,121,296.12 17.78 5,889,912.76 27,231,383.36 Total 62,329,598.16 15.71 9,793,858.02 52,535,740.14 At year end, provision for bad debts on those in third stage: Expected credit Provision for Carrying Category Book balance loss rate for the Reason bad debts amount lifetime(%) Provision for bad debts on 28,478,104.51 100.00 28,478,104.51 0.00 individual item Not expected to Other receivables 28,478,104.51 100.00 28,478,104.51 0.00 be recoverable Provision for bad debts on 0.00 0.00 0.00 0.00 -- portfolio basis Total 28,478,104.51 100.00 28,478,104.51 0.00 As of 31 December 2021, information of provision for bad debts: As of 31 December 2021, Provision for bad debts on those in first stage: Expected credit loss rate Provision for Carrying Category Book balance Reason in the next 12 bad debts amount months (%) Provision for bad debts on 32,542,166.20 0.00 0.00 32,542,166.20 individual item Amounts of exercised options 8,463,240.98 0.00 0.00 8,463,240.98 Expected to be recovered Capital reduction 24,078,925.22 0.00 0.00 24,078,925.22 Expected to be recovered Provision for bad debts on 0.00 0.00 0.00 0.00 -- portfolio basis Total 32,542,166.20 0.00 0.00 32,542,166.20 As of 31 December 2021, Provision for bad debts on those in second stage: Expected credit Provision for bad Carrying Category Book balance loss rate for the Reason debts amount lifetime(%) Provision for bad debts on 0.00 0.00 0.00 0.00 -- individual item Provision for bad debts on 63,594,020.80 13.28 8,448,235.52 55,145,785.28 portfolio basis Export tax refund receivable 17,708,111.60 1.12 198,927.69 17,509,183.91 Security deposits, deposits 11,003,281.04 26.33 2,897,272.69 8,106,008.35 and rental receivable Other receivables 34,882,628.16 15.34 5,352,035.14 29,530,593.02 Total 63,594,020.80 13.28 8,448,235.52 55,145,785.28 As of 31 December 2021, Provision for bad debts on those in third stage: Expected credit Provision for Carrying Category Book balance loss rate for the Reason bad debts amount lifetime(%) Provision for bad debts on 47,028,951.14 100.00 47,028,951.14 0.00 individual item Not expected to Other receivables 47,028,951.14 100.00 47,028,951.14 0.00 be recoverable 216 Joincare Pharmaceutical Group Annual Report 2022 Provision for bad debts on 0.00 0.00 0.00 0.00 -- portfolio basis Total 47,028,951.14 100.00 47,028,951.14 0.00 ④Accrual, recovery or reversal of bad debt provision during the year First stage Second stage Third stage Expected credit Provision for bad debts Expected credit Expected credit loss loss for lifetime Total loss within next for lifetime (no credit (credit 12 months impairment occurred) impairment has occurred) Beginning balance 0.00 8,448,235.52 47,028,951.14 55,477,186.66 Movement of beginning balance during the period --transfer to second stage 0.00 0.00 0.00 0.00 --transfer to third stage 0.00 -42,585.00 42,585.00 0.00 --Reverse to second stage 0.00 0.00 0.00 0.00 --Reverse to first stage 0.00 0.00 0.00 0.00 Provision for the year 0.00 1,304,163.32 0.00 1,304,163.32 Reversal in the year 0.00 0.00 -158,470.77 -158,470.77 Transfer in the year 0.00 0.00 0.00 0.00 Write-off in the year 0.00 138,045.77 18,434,960.86 18,573,006.63 Other movement 0.00 222,089.95 0.00 222,089.95 Closing balance 0.00 9,793,858.02 28,478,104.51 38,271,962.53 ⑤Actual written-off of other receivables in the year Item Written-off amount Actual written-off of other receivables 18,573,006.63 ⑥Other receivables due from the top five debtors Other Provision for Proportion to receivables bad debts Name of entity Nature Ageing total other Closing Closing receivables (%) balance balance Treasury Hua Xia Securities Co., Ltd. bonds and 17,968,386.04 Over 5 years 19.79 17,968,386.04 (华夏证券股份有限公司) security deposits Export tax Within one Tax refund on exports 16,539,609.68 18.21 290,344.77 rebate year Guangzhou Yinhe Sunshine Biological Products Co., Ltd. (广州银河阳光生物制品有限 Loan 5,000,000.00 Over 5 years 5.51 5,000,000.00 公司) People's Republic of China Wanchai Customs (中华人民共 Security Within one 1,271,801.36 1.40 12,718.01 deposits year 和国湾仔海关) Suzhou Sino Promise Import & Export Co., Ltd. (苏州中诺进 Security 1,200,000.00 1-2 years 1.32 60,000.00 deposits 出口有限公司) Total 41,979,797.08 46.23 23,331,448.82 217 Joincare Pharmaceutical Group Annual Report 2022 ⑦ There were no other receivables derecognised due to the transfer of financial assets in each reporting period. ⑧ There were no assets or liabilities formed by the continuing involvement of transferred other receivables in the period. 7. Inventories (1) Inventories by category 2022.12.31 2021.12.31 Item Provision for Provision for Book balance Carrying amount Book balance Carrying amount decline in value decline in value Raw materials 642,893,858.16 37,543,320.41 605,350,537.75 553,234,567.88 16,068,254.74 537,166,313.14 Packaging materials 137,488,629.87 11,191,692.58 126,296,937.29 125,197,237.91 7,099,883.19 118,097,354.72 Goods in process and Proprietary 649,362,917.78 65,482,989.52 583,879,928.26 538,151,968.97 2,891,675.04 535,260,293.93 semi-finished goods Low-value 80,473,347.95 495,743.41 79,977,604.54 61,806,078.47 217,760.90 61,588,317.57 consumables Finished goods and 1,138,363,946.23 22,354,857.60 1,116,009,088.63 834,035,538.26 30,182,179.43 803,853,358.83 stock goods Sub-contracting 2,318,531.50 0.00 2,318,531.50 2,251,074.26 0.00 2,251,074.26 materials Consumptive 13,692,837.04 0.00 13,692,837.04 12,342,303.96 0.00 12,342,303.96 biological assets Goods in transit 34,344,534.56 0.00 34,344,534.56 8,385,371.27 0.00 8,385,371.27 Total 2,698,938,603.09 137,068,603.52 2,561,869,999.57 2,135,404,140.98 56,459,753.30 2,078,944,387.68 (2) Provision for decline in value of inventories Increase Decrease Item 2021.12.31 2022.12.31 Reversal or Provision Others Others written-off Raw materials 16,068,254.74 23,631,216.36 0.00 2,156,150.69 0.00 37,543,320.41 Packaging materials 7,099,883.19 8,764,054.20 0.00 4,672,244.81 0.00 11,191,692.58 Goods in process and Proprietary semi-finished 2,891,675.04 63,112,373.68 0.00 521,059.20 0.00 65,482,989.52 goods Low-value consumables 217,760.90 289,387.02 0.00 11,404.51 0.00 495,743.41 Finished goods and stock 30,182,179.43 24,913,820.98 0.00 32,741,142.81 0.00 22,354,857.60 goods Total 56,459,753.30 120,710,852.24 0.00 40,102,002.02 0.00 137,068,603.52 Provision for decline in value of inventories (Continued) Reason for reversal or written-off of Basis in determination of net recoverable provision for decline in value of inventories/ Item amount/residual value and cost to be incurred Provision for impairment of contract performance cost The estimated selling price less the estimated costs of Raw materials Processing, sale of finished goods and discard completion, selling expenses and related taxes The estimated selling price less the estimated costs of Packaging materials Processing, sale of finished goods and discard completion, selling expenses and related taxes Goods in process and The estimated selling price less the estimated costs of Processing of finished goods and discard Proprietary semi-finished goods completion, selling expenses and related taxes Low-value consumables The estimated selling price less the related taxes Used or discard The estimated selling price less the estimated selling Finished goods and stock goods Sale and discard expenses and related taxes (3) There was no capitalization of borrowing costs in the balance of inventories at the end of the period. 8. Non-current assets due within one year 218 Joincare Pharmaceutical Group Annual Report 2022 Item 2022.12.31 2021.12.31 Long-term receivables due within one year 0.00 317,381.23 Fixed deposits due within 1 year 54,048,611.11 0.00 Total 54,048,611.11 317,381.23 9. Other current assets Item 2022.12.31 2021.12.31 Input VAT pending deduction /Input tax 35,679,462.66 53,179,328.86 pending for verification Prepaid income tax 17,665,709.39 30,667,849.83 Cash management 92,815,738.44 0.00 Return cost receivable 12,043,428.52 0.00 Others 5,335,561.31 139,035.68 Total 163,539,900.32 83,986,214.37 10. Long-term receivables (1) Long-term receivables by nature 2022.12.31 2021.12.31 Range of Item Provision Provision discount Book Carrying Carrying for bad Book balance for bad rate balance amount amount debts debts Financing lease 0.00 0.00 0.00 584,285.36 0.00 584,285.36 4.75% payments Less: Long-term receivables due 0.00 0.00 0.00 317,381.23 0.00 317,381.23 within one year Total 0.00 0.00 0.00 266,904.13 0.00 266,904.13 (2) There was no situation of overdue of long-term receivables in the period. (3) There was no long-term receivables derecognized due to the transfer of financial assets in the period. (4) There was no assets or liabilities formed by the continuing involvement of transferred long-term receivables in the period. 219 Joincare Pharmaceutical Group Annual Report 2022 11. Long-term equity investment Movement in the year Closing balance of Investee 2021.12.31 Announced 2022.12.31 provision for Investment gain or Provision Additions in Decrease in Adjustment in other Changes of other distribution of impairment loss under equity for Others investment investment comprehensive income equity cash dividend or method impairment profit ①Subsidiaries Zhongshan Renhe Health Products Co., Ltd. (中山市仁和保健品有限 6,337,823.35 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 6,337,823.35 6,337,823.35 公司) Guangzhou Hiyeah Industry Co., 1,949,893.45 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1,949,893.45 1,949,893.45 Ltd. (广州市喜悦实业有限公司) Subtotal 8,287,716.80 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 8,287,716.80 8,287,716.80 ②Associates Livzon Medical Electronic Equipment (Plant) Co., Ltd. (丽珠 1,200,000.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1,200,000.00 1,200,000.00 集团丽珠医用电子设备有限公 司) Guangdong Blue Treasure Pharmaceutical Co. Ltd. (广东蓝 78,029,592.18 0.00 0.00 15,055,174.10 0.00 0.00 0.00 0.00 0.00 93,084,766.28 0.00 宝制药有限公司) Shenzhen City Youbao Technology Co., Ltd. (深圳市有 1,222,398.89 0.00 0.00 274,196.51 0.00 0.00 0.00 0.00 0.00 1,496,595.40 0.00 宝科技有限公司) AbCyte Therapeutics Inc. 15,154,709.96 0.00 0.00 -1,387,449.90 0.00 0.00 0.00 0.00 0.00 13,767,260.06 0.00 L&L Biopharma, Co. Ltd. (上海健 14,886,838.46 0.00 0.00 -983,161.97 0.00 0.00 0.00 0.00 0.00 13,903,676.49 0.00 信生物医药科技有限公司) Zhuhai Sanmed Biotech Inc. (珠海 83,155,557.16 0.00 0.00 -22,889,193.47 527,718.52 497,687.40 0.00 0.00 0.00 61,291,769.61 0.00 圣美生物诊断技术有限公司) Aetio Biotheraphy, Inc. 16,028,488.48 0.00 0.00 5,826.20 0.00 0.00 0.00 0.00 0.00 16,034,314.68 0.00 Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd. (江苏新 67,908,607.98 30,000,000.00 0.00 -5,105,198.56 0.00 0.00 0.00 0.00 0.00 92,803,409.42 0.00 元素医药科技有限公司) Tianjin Tongrentang Group Co., Ltd. (天津同仁堂集团股份有限 751,549,763.92 0.00 0.00 82,286,589.62 4,723,927.54 0.00 111,980,000.00 0.00 0.00 726,580,281.08 0.00 公司) Infinite Intelligence Pharmaceutical Co. Ltd. (北京英 19,937,909.64 0.00 0.00 -1,080,182.56 0.00 0.00 0.00 0.00 0.00 18,857,727.08 0.00 飞智药科技有限公司) Shenzhen Kangti Biomedical Technology Co., Ltd. (深圳康体生 0.00 6,000,000.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 6,000,000.00 0.00 物医药科技有限公司)(Note 1) Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. (焦作金冠嘉华电 284,619,909.01 0.00 0.00 918,586.51 0.00 0.00 0.00 0.00 0.00 285,538,495.52 0.00 力有限公司) 220 Joincare Pharmaceutical Group Annual Report 2022 Movement in the year Closing balance of Investee 2021.12.31 Announced 2022.12.31 provision for Investment gain or Provision Additions in Decrease in Adjustment in other Changes of other distribution of impairment loss under equity for Others investment investment comprehensive income equity cash dividend or method impairment profit Ningbo Ningrong Biomedical Co., Ltd. (宁波宁融生物医药有限公 27,464,098.71 0.00 0.00 -284,889.20 0.00 0.00 0.00 0.00 0.00 27,179,209.51 0.00 司) Feellife Health Inc. (深圳来福士 12,734,373.22 0.00 0.00 2,569,122.52 0.00 0.00 0.00 0.00 0.00 15,303,495.74 0.00 雾化医学有限公司) Novastage Pharmaceuticals (Shenzhen) , Ltd. (新领医药技术 18,080,883.21 0.00 18,080,883.21 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 (深圳) 有限公司) Jiangsu Baining Yingchuang Medical Technology Co., Ltd. (江 28,576,324.02 0.00 0.00 156,057.09 0.00 0.00 0.00 0.00 0.00 28,732,381.11 0.00 苏百宁盈创医疗科技有限公司) Shanghai Sheo Pharmaceutical Technology Co., Ltd. (上海偕怡 0.00 17,000,000.00 0.00 2,309,212.61 0.00 0.00 0.00 0.00 0.00 19,309,212.61 0.00 医药科技有限公司)(Note 2) Subtotal 1,420,549,454.84 53,000,000.00 18,080,883.21 71,844,689.50 5,251,646.06 497,687.40 111,980,000.00 0.00 0.00 1,421,082,594.59 1,200,000.00 Total 1,428,837,171.64 53,000,000.00 18,080,883.21 71,844,689.50 5,251,646.06 497,687.40 111,980,000.00 0.00 0.00 1,429,370,311.39 9,487,716.80 Note 1: On 30 September 2022, the Company's subsidiary, Zhuhai Livzon Pharmaceutical Equity Investment Management Co., Ltd. (珠海市丽珠医药股权投资管理有限公司) ("Equity Investment Company") and Shenzhen Kangti Biomedical Technology Co., Ltd. (深圳康体生物医药科技有限公司) (“Kangti Biomedical”) signed a shareholder agreement. Equity Investment Company invested RMB10 million to hold a 3.1746% shareholding in Kangti Biomedical (including the first phase of investment of RMB6 million). According to the shareholder agreement and the articles of association, Equity Investment Company appointed a director to Kangti Biomedical. Since Equity Investment Company is able to exercise significant influence over Kangti Biomedical, the investment in Kangti Biomedical is accounted for as a long-term equity investment. Note 2: On April 22, 2022, Shanghai Frontier Health Pharmaceutical Technology Co., Ltd. (上海方予健康医药科技有限公司) ("Shanghai Frontier") ,a subsidiary of the Company, acquired 20% of the equity of Shanghai Sheo Pharmaceutical Technology Co., Ltd. (上海偕怡医药科技有限公司) (“Shanghai Sheo”) from the original shareholders for RMB7 million; On October 28, 2022, the Company signed a capital increase agreement with Shanghai Sheo, investing RMB10 million to hold 10% of the equity of Shanghai Sheo. After the company's investment, the stake of the Shanghai Frontier will be reduced to 17.999%. 221 Joincare Pharmaceutical Group Annual Report 2022 12. Other equity instruments investment Reason for Item 2022.12.31 2021.12.31 designation China Galaxy Securities Co., Ltd. (中国银河证券 0.00 212,384,666.97 Non-trading 股份有限公司) Shanghai Yunfeng Xinchuang Equity Investment 67,935,704.36 94,040,236.88 Non-trading Center (上海云锋新创股权投资中心) Shanghai JingYi Investment Center (上海经颐投 73,616,359.91 66,175,062.50 Non-trading 资中心) Qianhai Equity Investment Fund (前海股权投资 243,378,742.17 264,930,500.00 Non-trading 基金) Apricot Forest, Inc (杏树林) 120,788,500.00 137,711,800.01 Non-trading PANTHEON D ,L.P. 5,954,301.20 3,715,566.69 Non-trading Zhuhai China Resources Bank Co., Ltd. (珠海华 158,400,000.00 164,395,200.00 Non-trading 润银行股份有限公司) GLOBAL HEALTH SCIENCE 271,980,388.15 235,133,216.46 Non-trading Nextech V Oncology S.C.S., SICAV-SIF 23,996,121.32 30,667,263.04 Non-trading Yizun Biopharmaceutics (Shanghai) Co., Ltd. (羿 30,513,209.27 59,999,953.41 Non-trading 尊生物医药(上海) 有限公司) ELICIO THERAPEUTICS, INC. 34,823,014.36 31,878,510.16 Non-trading CARIAMA THER APEUTICS INC. 34,821,295.50 31,876,936.63 Non-trading Beijing Luzhu Biotechnology Co., Ltd. (北京绿竹 53,654,738.60 41,944,015.67 Non-trading 生物技术股份有限公司) Shanghai Keentai Biotechnology Co., Ltd. (上海 12,000,000.00 12,000,000.00 Non-trading 科恩泰生物医药科技有限公司) Others 62,096,504.21 22,029,449.00 Non-trading Total 1,193,958,879.05 1,408,882,377.42 Continued: Amount transferred from Dividend income Cumulative other Reason of Item recognised in the Cumulative gain loss comprehensive transfer year income to retained earnings China Galaxy Securities Co., Ltd. 0.00 0.00 0.00 94,089,666.09 Disposal (中国银河证券股份有限公司) Shanghai Yunfeng Xinchuang Equity Investment Center (上海云 0.00 0.00 0.00 -4,367,599.87 Disposal- 锋新创股权投资中心) Shanghai JingYi Investment 512,350.35 0.00 0.00 0.00 -- Center (上海经颐投资中心) Qianhai Equity Investment Fund 13,160,623.21 0.00 0.00 0.00 -- (前海股权投资基金) Apricot Forest, Inc (杏树林) 0.00 0.00 0.00 0.00 -- PANTHEON D ,L.P. 0.00 0.00 0.00 0.00 -- Zhuhai China Resources Bank Co., Ltd. (珠海华润银行股份有 0.00 0.00 0.00 0.00 -- 限公司) GLOBAL HEALTH SCIENCE 3,956,817.66 0.00 0.00 0.00 -- Nextech V Oncology S.C.S., 1,053,846.01 0.00 0.00 0.00 -- SICAV-SIF 222 Joincare Pharmaceutical Group Annual Report 2022 Amount transferred from Dividend income Cumulative other Reason of Item recognised in the Cumulative gain loss comprehensive transfer year income to retained earnings Yizun Biopharmaceutics (Shanghai) Co., Ltd. (羿尊生物医 0.00 0.00 0.00 0.00 -- 药(上海) 有限公司) ELICIO THERAPEUTICS, INC. 0.00 0.00 0.00 0.00 -- CARIAMA THER APEUTICS 0.00 0.00 0.00 0.00 -- INC. Beijing Luzhu Biotechnology Co., Ltd. (北京绿竹生物技术股份有 0.00 0.00 0.00 0.00 -- 限公司) Shanghai Keentai Biotechnology Co., Ltd. (上海科恩泰生物医药 0.00 0.00 0.00 0.00 -- 科技有限公司) Others 30,000.00 0.00 0.00 0.00 -- Total 18,713,637.23 0.00 0.00 89,722,066.22 -- 13. Investment properties Housing and Item Total buildings I. Book value 1. Beginning balance 61,914,754.28 61,914,754.28 2.Increase 0.00 0.00 3.Decrease 0.00 0.00 4.Closing balance 61,914,754.28 61,914,754.28 II. Accumulated depreciation and amortisation 1.Beginning balance 55,723,278.85 55,723,278.85 2.Increase 0.00 0.00 (1) Amortisation for the year 0.00 0.00 3.Decrease 0.00 0.00 (1) Disposal 0.00 0.00 4. Closing balance 55,723,278.85 55,723,278.85 III. Provision for impairment 0.00 0.00 1.Beginning balance 0.00 0.00 2.Increase 0.00 0.00 (1) Provision 0.00 0.00 3. Decrease 0.00 0.00 (1) Disposal 0.00 0.00 4.Closing balance 0.00 0.00 IV. Carrying amount 1.Carrying value at year end 6,191,475.43 6,191,475.43 2.Carrying value at beginning of year 6,191,475.43 6,191,475.43 223 Joincare Pharmaceutical Group Annual Report 2022 14. Fixed assets Item 2022.12.31 2021.12.31 Fixed assets 5,265,200,110.91 4,839,005,169.81 Fixed assets for disposal 0.00 0.00 Total 5,265,200,110.91 4,839,005,169.81 (1) Fixed assets ①Details of fixed assets Electronic Housing and Machinery and Item Motor vehicles equipment and Total buildings equipment others I. Book value: 1.Beginning balance 3,976,199,210.91 5,119,816,758.02 108,015,330.21 783,366,162.98 9,987,397,462.12 2.Increase 342,127,376.83 628,876,021.14 6,461,652.11 97,012,190.24 1,074,477,240.32 (1) Purchase 65,441,049.18 147,389,281.70 5,280,741.59 58,931,934.55 277,043,007.02 (2) Transfer from 276,686,327.65 481,486,739.44 0.00 15,719,395.68 773,892,462.77 construction in progress (3) Others 0.00 0.00 1,180,910.52 22,360,860.01 23,541,770.53 3.Decrease 13,272,568.72 111,148,294.43 8,185,405.44 23,825,880.16 156,432,148.75 (1) Disposal or scrap 13,272,568.72 111,148,294.43 8,185,405.44 23,825,880.16 156,432,148.75 4.Closing balance 4,305,054,019.02 5,637,544,484.73 106,291,576.88 856,552,473.06 10,905,442,553.69 II. Accumulated - - - - - depreciation 1.Beginning balance 1,633,263,266.38 2,850,461,052.50 76,499,140.97 478,176,262.36 5,038,399,722.21 2.Increase 181,477,081.95 346,324,779.03 10,462,940.46 81,920,529.52 620,185,330.96 (1) Provision 181,477,081.95 346,324,779.03 9,296,030.33 81,920,529.52 619,018,420.83 (2) Other increase 0.00 0.00 1,166,910.13 0.00 1,166,910.13 3.Decrease 7,852,119.16 86,818,439.43 4,791,950.88 21,842,549.49 121,305,058.96 (1) Disposal or scrap 7,852,119.16 86,818,439.43 4,791,950.88 21,842,549.49 121,305,058.96 4.Closing balance 1,806,888,229.17 3,109,967,392.10 82,170,130.55 538,254,242.39 5,537,279,994.21 III. Provision for - - - - - impairment 1.Beginning balance 26,564,784.45 64,186,228.26 41,578.65 19,199,978.74 109,992,570.10 2.Increase 0.00 161,670.35 0.00 24,878.03 186,548.38 (1) Provision 0.00 161,670.35 0.00 24,878.03 186,548.38 3.Decrease 90,292.62 6,798,397.52 41,578.65 286,401.12 7,216,669.91 (1) Disposal or scrap 90,292.62 6,798,397.52 41,578.65 286,401.12 7,216,669.91 4.Closing balance 26,474,491.83 57,549,501.09 0.00 18,938,455.65 102,962,448.57 IV. Carrying amount - - - - - 1. Carrying value at 2,471,691,298.02 2,470,027,591.54 24,121,446.33 299,359,775.02 5,265,200,110.91 period end 2. Carrying value at 2,316,371,160.08 2,205,169,477.26 31,474,610.59 285,989,921.88 4,839,005,169.81 beginning of year 224 Joincare Pharmaceutical Group Annual Report 2022 ②Fixed assets with temporary idle Accumulated Provision for Item Book value Carrying amount Note depreciation impairment Housing and buildings 23,926,279.99 14,490,518.30 5,155,770.80 4,279,990.89 Machinery and 169,656,887.40 117,171,435.61 35,728,561.41 16,756,890.38 equipment Electronic equipment 3,119,826.93 2,533,159.51 180,534.90 406,132.52 and others Total 196,702,994.32 134,195,113.42 41,064,867.11 21,443,013.79 ③Fixed assets held under finance leases Item Carrying amount Housing and buildings 1,753,301.29 ④Fixed assets without property certificate Item Carrying amount Reasons for pending title certificate Housing and buildings 182,318,779.85 Application in progress 15. Construction in progress Item 2022.12.31 2021.12.31 Construction in progress 810,835,273.97 742,533,534.23 Construction materials 464,794.99 465,209.52 Total 811,300,068.96 742,998,743.75 ① Information of construction in progress 2022.12.31 2021.12.31 Item Provision for Provision for Book balance Net book value Book balance Net book value impairment impairment Haibin Pharma Pingshang New 133,771,969.05 11,068,266.54 122,703,702.51 144,364,877.42 0.00 144,364,877.42 Factory (深圳海滨坪山新厂) Guangda New Factory Project 360,963,893.27 0.00 360,963,893.27 179,745,064.48 0.00 179,745,064.48 Fuxing Company Phase I & II Projects and others (福兴公司I. 38,842,449.73 0.00 38,842,449.73 36,580,114.83 0.00 36,580,114.83 二期项目及其他) Project of Shijiao New Factory 12,409,895.73 0.00 12,409,895.73 61,845,397.73 0.00 61,845,397.73 (石角新厂项目) Transformation Project of Pharmaceutical Factory 70,972,186.23 0.00 70,972,186.23 19,579,452.17 0.00 19,579,452.17 Workshop (药厂车间建设项目) Construction Project for Microsphere Workshop (including Gose) of Livzon Group Livzon Pharmaceutical 39,976,590.91 0.00 39,976,590.91 15,616,651.12 0.00 15,616,651.12 Factory (丽珠制药厂) 微球车间 (含戈舍) 建设项目) P06 Construction Project of Livzon Group Livzon 180,053.79 0.00 180,053.79 83,020,966.01 0.00 83,020,966.01 Pharmaceutical Factory (丽珠制 药厂) P06建设项目) Project of lyophilized powder injection workshop (冻干粉针车 1,157,559.47 0.00 1,157,559.47 70,673,332.62 0.00 70,673,332.62 间项目) P09 Construction Project of 0.00 0.00 0.00 54,924,595.61 0.00 54,924,595.61 Livzon Group Livzon 225 Joincare Pharmaceutical Group Annual Report 2022 2022.12.31 2021.12.31 Item Provision for Provision for Book balance Net book value Book balance Net book value impairment impairment Pharmaceutical Factory (丽珠制 药厂) P09建设项目) P04/P05 Construction Project of Livzon Group Livzon 1,560,960.52 0.00 1,560,960.52 257,441.66 0.00 257,441.66 Pharmaceutical Factory (丽珠制 药厂) P04/P05建设项目) Shanghai Livzon-Microsphere Phase II Technical 34,677,843.69 0.00 34,677,843.69 10,123,776.54 0.00 10,123,776.54 Transformation Project (上海丽 珠-微球二期技改项目) Others 127,559,478.58 169,340.46 127,390,138.12 65,971,204.50 169,340.46 65,801,864.04 Total 822,072,880.97 11,237,607.00 810,835,273.97 742,702,874.69 169,340.46 742,533,534.23 ②Changes in significant construction in progress Including: Interest Cumulativ interest capitalisati Transfer to fixed e amount Name of Project 2021.12.31 Increase Other decrease capitalise on rate for 2022.12.31 assets of interest d in the the year capitalised year (%) Haibin Pharma Pingshang New Factory 144,364,877.42 218,228,529.86 164,393,809.16 64,427,629.07 0.00 0.00 0.00 133,771,969.05 (深圳海滨坪山新厂) Guangda New Factory 179,745,064.48 181,218,828.79 0.00 0.00 0.00 0.00 0.00 360,963,893.27 Project (光大新厂项目) Fuxing Company Phase I & II Projects and 36,580,114.83 77,051,711.32 74,789,376.42 0.00 0.00 0.00 0.00 38,842,449.73 others (福兴公司一、 二期项目及其他) Project of Shijiao New Factory (石角新厂项 61,845,397.73 30,318,359.71 79,753,861.71 0.00 0.00 0.00 0.00 12,409,895.73 目) Transformation Project of Pharmaceutical Factory Workshop (药 19,579,452.17 70,984,195.20 19,591,461.14 0.00 0.00 0.00 0.00 70,972,186.23 厂车间建设项目) Construction Project for Microsphere Workshop (including Gose) of Livzon Group Livzon Pharmaceutical Factory 15,616,651.12 29,308,744.91 4,948,805.12 0.00 0.00 0.00 0.00 39,976,590.91 (丽珠集团丽珠制药厂 微球车间(含戈舍) 建 设项目) P06 Construction Project of Livzon Group Livzon Pharmaceutical 83,020,966.01 7,323,839.40 90,164,751.62 0.00 0.00 0.00 0.00 180,053.79 Factory (丽珠集团丽珠 制药厂 P06 建设项目) Project of lyophilized powder injection 70,673,332.62 49,803,364.24 119,319,137.39 0.00 0.00 0.00 0.00 1,157,559.47 workshop 冻干粉针车 间项目) P09 Construction Project of Livzon Group Livzon Pharmaceutical 54,924,595.61 99,318,116.09 154,242,711.70 0.00 0.00 0.00 0.00 0.00 Factory (丽珠集团丽珠 制药厂 P09 建设项目) P04/P05 Construction Project of Livzon Group Livzon Pharmaceutical Factory (丽珠集团丽珠 257,441.66 1,303,518.86 0.00 0.00 0.00 0.00 0.00 1,560,960.52 制药厂 P04/P05 建设项 目) Technology transformation project 10,123,776.54 24,554,067.15 0.00 0.00 0.00 0.00 0.00 34,677,843.69 for Microsphere Phase II of Shanghai Livzon 226 Joincare Pharmaceutical Group Annual Report 2022 Including: Interest Cumulativ interest capitalisati Transfer to fixed e amount Name of Project 2021.12.31 Increase Other decrease capitalise on rate for 2022.12.31 assets of interest d in the the year capitalised year (%) (上海丽珠微球二期技 改项目) Others 65,971,204.50 151,152,406.67 66,688,548.51 22,875,584.08 0.00 0.00 0.00 127,559,478.58 Total 742,702,874.69 940,565,682.20 773,892,462.77 87,303,213.15 0.00 0.00 0.00 822,072,880.97 Changes in significant construction in progress (Continued) : Proportion of Name of Project Budget cumulative input Progress % Source of fund to budget % Haibin Pharma Pingshang New Completion of Self-funding and funds 1,037,000,000.00 78.1 some projects raised Factory (深圳海滨坪山新厂) Guangda New Factory Project (光大 646,000,000.00 55.88 Under construction Self-funding 新厂项目) Fuxing Company Phase I & II Projects Completion of and others (福兴公司一、二期项目 378,090,800.00 87.45 Self-funding some projects 及其他) Project of Shijiao New Factory (石角 Completion of Self-funding and funds 377,005,000.00 89.92 新厂项目) some projects raised Transformation Project of Completion of Pharmaceutical Factory Workshop (药 306,558,388.48 61.17 Self-funding some projects 厂车间建设项目) Construction Project for Microsphere Workshop (including Gose) of Livzon Group Livzon Pharmaceutical Factory 262,445,000.00 Completion of Self-funding and funds 65.12 some projects raised (丽珠集团丽珠制药厂微球车间(含 戈舍) 建设项目) P06 Construction Project of Livzon Group Livzon Pharmaceutical Factory Completion of 117,710,000.00 95.02 Self-funding (丽珠集团丽珠制药厂 P06 建设项 some projects 目) Project of lyophilized powder Completion of Self-funding and funds injection workshop (冻干粉针车间项 143,500,000.00 95.11 some projects raised 目) P09 Construction Project of Livzon Group Livzon Pharmaceutical Factory 296,580,000.00 100.00 Completed Self-funding (丽珠丽珠制药厂 P09 建设项目) P04/P05 Construction Project of Livzon Group Livzon Pharmaceutical Factory (丽珠集团丽珠制药厂 126,880,000.00 1.23 Under construction Self-funding P04/P05 建设项目) Technology transformation project for Microsphere Phase II of Shanghai Livzon (上海丽珠微球二期技改项 40,500,000.00 85.62 Under construction Self-funding 目) Others -- -- -- Self-funding Total 3,732,269,188.48 -- -- -- Other decrease is mainly transferred to long-term deferred expenses. 16. Right-of-use assets Item Housing and buildings Total I. Book value: 227 Joincare Pharmaceutical Group Annual Report 2022 Item Housing and buildings Total 1.Beginning balance 69,960,518.27 69,960,518.27 2.Increase 29,002,437.68 29,002,437.68 (1) Leasing 29,002,437.68 29,002,437.68 3.Decrease 20,627,100.42 20,627,100.42 4. Closing balance 78,335,855.53 78,335,855.53 II. Accumulated depreciation 1.Beginning balance 23,185,758.58 23,185,758.58 2.Increase 32,367,074.98 32,367,074.98 (1) Provision 32,367,074.98 32,367,074.98 3.Decrease 19,060,112.00 19,060,112.00 4.Closing balance 36,492,721.56 36,492,721.56 III. Provision for impairment 1.Beginning balance 0.00 0.00 2.Increase 0.00 0.00 3.Decrease 0.00 0.00 4.Closing balance 0.00 0.00 IV. Carrying amount 1.Carrying value at year 41,843,133.97 41,843,133.97 end 2.Carrying value at 46,774,759.69 46,774,759.69 beginning of year As of 31 December 2022, the Company recognised lease expenses related to short-term leases and the leases of low value assets of RMB239,280. 17. Intangible assets (1) Details of intangible assets Patent and Trademark Item Land use rights Software Others Total technical know-how rights I. Book value 1.Beginning balance 413,762,737.87 519,813,876.67 79,232,390.69 62,769,716.98 10,985,294.53 1,086,564,016.74 2.Increase 28,488,823.32 496,141,693.87 14,020,493.45 0.00 0.00 538,651,010.64 (1) Purchase 28,488,823.32 1,100,000.00 14,020,493.45 0.00 0.00 43,609,316.77 (2) Internal R&D 0.00 495,041,693.87 0.00 0.00 0.00 495,041,693.87 3.Decrease 0.00 0.00 0.00 0.00 0.00 0.00 Disposal 0.00 0.00 0.00 0.00 0.00 0.00 4.Closing balance 442,251,561.19 1,015,955,570.54 93,252,884.14 62,769,716.98 10,985,294.53 1,625,215,027.38 II. Accumulated amortisation 1.Beginning balance 122,997,170.29 369,635,517.03 56,287,892.35 62,765,196.55 5,584,191.37 617,269,967.59 2.Increase 9,122,311.45 172,774,379.26 7,114,468.80 471.72 1,098,529.45 190,110,160.68 Provision 9,122,311.45 172,774,379.26 7,114,468.80 471.72 1,098,529.45 190,110,160.68 3.Decrease 0.00 0.00 0.00 0.00 0.00 0.00 228 Joincare Pharmaceutical Group Annual Report 2022 Patent and Trademark Item Land use rights Software Others Total technical know-how rights Disposal 0.00 0.00 0.00 0.00 0.00 0.00 4.Closing balance 132,119,481.74 542,409,896.29 63,402,361.15 62,765,668.27 6,682,720.82 807,380,128.27 III. Provision for impairment 1.Beginning balance 981,826.94 11,530,127.41 0.00 0.00 0.00 12,511,954.35 2.Increase 0.00 3,207,819.01 0.00 0.00 0.00 3,207,819.01 Provision 0.00 3,207,819.01 0.00 0.00 0.00 3,207,819.01 3.Decrease 0.00 0.00 0.00 0.00 0.00 0.00 4.Closing balance 981,826.94 14,737,946.42 0.00 0.00 0.00 15,719,773.36 IV. Carrying amount 1.Carrying value at 309,150,252.51 458,807,727.83 29,850,522.99 4,048.71 4,302,573.71 802,115,125.75 year end 2.Carrying value at 289,783,740.64 138,648,232.23 22,944,498.34 4,520.43 5,401,103.16 456,782,094.80 beginning of year As of 31 December 2022, intangible assets formed through internal research and development of the company account for 39.03% of the balance of intangible assets. At the balance sheet date, the Company engaged an appraiser to test the impairment of biopharmaceutical technologies of the current period carry-over intangible assets, using the biotechnology-related asset group to estimate the present value of future cash flows in anticipation of the recoverable amount of input costs. The asset group was tested as not impaired. The projected future cash flows of the asset group are determined on the basis of the financial budget for the next five years established by management, and the cash flow for the years beyond which the five-year financial budget is zero. The main assumptions of discounted future cash flows in the impairment test are as follows: The calculation of the projected present future cash flow value of the asset group related to this biotechnology uses a gross margin of 84.50%-91.50% and an operating income growth rate of -93%~71%, and a discount cash flow rate of 15.00% as key assumptions. Management determines these assumptions based on historical conditions prior to the budget period and projections of market developments. (2) Intangible assets pending for certificates of ownership Item Carrying amount Reasons for pending title certificate Land use rights 4,012,089.17 Application in progress (3) Intangible assets The land use rights represent the state-owned land use rights obtained by the Company in accordance with PRC laws in China, and the term of grant will be 50 years commencing from the date of obtaining the land use rights 18. Development costs Increase Decrease Item 2021.12.31 Internal Recognized as Recognised in 2022.12.31 Other development intangible profit or loss in increase costs assets the year Chemical 179,411,666.34 99,354,717.46 0.00 75,078,369.10 66,830,198.83 136,857,815.87 pharmaceuticals Biologics 527,275,067.73 92,785,310.25 0.00 381,832,741.41 0.00 238,227,636.57 229 Joincare Pharmaceutical Group Annual Report 2022 APIs and others 80,306,701.64 11,023,313.45 0.00 38,130,583.36 0.00 53,199,431.73 Total 786,993,435.71 203,163,341.16 0.00 495,041,693.87 66,830,198.83 428,284,884.17 Continued: Time for commencement Progress of research and Item Specific basis of capitalisation of capitalisation development at year end Chemical Clinical trial Obtain approval for clinical trial Clinical stage pharmaceuticals Biologics Clinical trial Obtain approval for clinical trial Clinical stage APIs and others Pilot stage Pilot related information Post-pilot stage 19. Goodwill (1) Book value of goodwill Increase Decrease Name of investee or matter from which goodwill 2021.12.31 Formation by 2022.12.31 arose Disp business Others Others osal combination Shanghai Livzon Pharmaceutical Manufacturing 2,045,990.12 0.00 0.00 0.00 0.00 2,045,990.12 Co., Ltd. (上海丽珠制药有限公司) Zhuhai FTZ Livzon Hecheng Pharmaceutical Manufacturing Co., Ltd. (珠海保税区丽珠合成制 3,492,752.58 0.00 0.00 0.00 0.00 3,492,752.58 药有限公司) Sichuan Guangda Pharmaceutical Manufacturing 13,863,330.24 0.00 0.00 0.00 0.00 13,863,330.24 Co., Ltd. (四川光大制药有限公司) Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc. (丽珠集团新北江制药股份有 7,271,307.03 0.00 0.00 0.00 0.00 7,271,307.03 限公司) Livzon Group Fuzhou Fuxing Pharmaceutical Co., 46,926,155.25 0.00 0.00 0.00 0.00 46,926,155.25 Ltd. (丽珠集团福州福兴医药有限公司) Livzon Group Livzon Pharmaceutical Factory (丽珠 47,912,269.66 0.00 0.00 0.00 0.00 47,912,269.66 制药厂) Livzon Group 395,306,126.41 0.00 0.00 0.00 0.00 395,306,126.41 Shenzhen Haibin Pharmaceutical Co., Ltd. (深圳市 91,878,068.72 0.00 0.00 0.00 0.00 91,878,068.72 海滨制药有限公司) Joincare Daily-Use & Health Care Co., Ltd. (健康 1,610,047.91 0.00 0.00 0.00 0.00 1,610,047.91 元日用保健品有限公司) Shenzhen Taitai Pharmaceutical Co., Ltd. (深圳太 635,417.23 0.00 0.00 0.00 0.00 635,417.23 太药业有限公司) Health Pharmaceuticals (China) Limited (健康药业 23,516,552.65 0.00 0.00 0.00 0.00 23,516,552.65 (中国) 有限公司) Shenzhen Hiyeah Industry Co., Ltd (深圳市喜悦实 6,000,000.00 0.00 0.00 0.00 0.00 6,000,000.00 业有限公司) Jiaozuo Joincare Bio Technological Co., Ltd. (焦作 92,035.87 0.00 0.00 0.00 0.00 92,035.87 健康元生物制品有限公司) Total 640,550,053.67 0.00 0.00 0.00 0.00 640,550,053.67 (2) Provision for impairment of goodwill Increase Decrease Name of investee or matter from which goodwill 2021.12.31 2022.12.31 arose Dispos Provision Others Others al Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc. (丽珠集团新北江制药股份有限 7,271,307.03 0.00 0.00 0.00 0.00 7,271,307.03 公司) Livzon Group Fuzhou Fuxing Pharmaceutical Co., 11,200,000.00 0.00 0.00 0.00 0.00 11,200,000.00 Ltd. (丽珠集团福州福兴医药有限公司) Shenzhen Hiyeah Industry Co., Ltd (深圳市喜悦实 6,000,000.00 0.00 0.00 0.00 0.00 6,000,000.00 业有限公司) Joincare Daily-Use & Health Care Co., Ltd. (健康元 1,610,047.91 0.00 0.00 0.00 0.00 1,610,047.91 日用保健品有限公司) Total 26,081,354.94 0.00 0.00 0.00 0.00 26,081,354.94 230 Joincare Pharmaceutical Group Annual Report 2022 Goodwill of the Company arose from its business combination involving enterprises not under common control in previous years. On the balance sheet date, the Company conducts an impairment test on goodwill. When estimating the recoverable amount of input costs, it uses a assets group related to goodwill to estimate the present value of future cash flows. The estimated future cash flow of asset groups is calculated according to the five-year financial budget plan made by the management, the cash flows in the years beyond the five-year budget plan remain stable. Key assumptions of discounted future cash flow for goodwill impairment test are as follows: For the calculation of estimated present value of future cash flow of the asset groups related to goodwill of Livzon Group, key assumptions are a gross margin of 63.27%-63.46% and a business revenue growth rate of 0-9.08% as well as a cash flow discount rate of 12.21%. The management took into account historical conditions and predictions for future market development in making the above assumptions. For the calculation of estimated present value of future cash flow of the asset groups related to goodwill of Shenzhen Haibin Pharmaceutical Co., Ltd. (深圳市海滨制药有限公司), key assumptions are a gross margin of 38.91%-40.11% and a business revenue growth rate of -9.19~2.79% as well as a cash flow discount rate of 11.78%. The management took into account historical conditions and predictions for future market development in making the above assumptions. The calculation of the estimated future present value of the goodwill-related asset portfolio of Livzon Group Livzon Pharmaceutical Manufacturing Factory uses a gross profit margin of 82.19%-83.33% and an operating income growth rate of 0~7.83%, and a discount cash flow rate of 14.72% as key assumptions. Management determines these assumptions based on historical conditions prior to the budget period and projections of market developments. The calculation of the expected future present value of goodwill-related asset portfolio of Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd. uses a gross profit margin of 63.43%-64.44% and an operating income growth rate of 0~11.80%, and a discount cash flow rate of 15.04% as key assumptions. Management determines these assumptions based on historical conditions prior to the budget period and projections of market developments. As tested, the management of the Company expects that no impairment provision is needed during the period. 20. Long-term deferred expenses Decrease Item 2021.12.31 Increase Other 2022.12.31 Amortization decrease Renovation costs of 26,940,700.02 9,114,501.74 3,437,654.72 212,648.78 32,404,898.26 offices Renovation costs of 138,705,258.94 70,216,911.41 31,651,658.96 0.00 177,270,511.39 plants Certification costs of 311,654.79 0.00 120,640.56 0.00 191,014.23 GMP project Others 34,758,127.18 56,097,158.72 22,844,892.83 9,100.00 68,001,293.07 Total 200,715,740.93 135,428,571.87 58,054,847.07 221,748.78 277,867,716.95 21. Deferred tax assets and deferred tax liabilities (1) Deferred tax assets and deferred tax liabilities before offsetting 231 Joincare Pharmaceutical Group Annual Report 2022 2022.12.31 2021.12.31 Item Deductible or Deductible or Deferred tax Deferred tax taxable timing taxable timing assets or assets or liabilities differences differences liabilities Deferred tax assets: Provision for impairment of assets 336,502,793.26 51,790,732.85 323,372,877.26 54,704,601.96 Deductible difference arising from 965,912,234.46 145,014,131.32 945,774,497.50 166,481,490.01 accrued expenses Deductible difference arising from tax 399,128,528.63 61,021,514.54 497,850,865.29 84,167,365.69 loss Deferred income 329,970,021.95 49,511,503.29 375,321,674.10 60,145,851.14 Unrealised gains from intra-company 694,726,037.62 104,182,311.29 560,934,298.63 84,185,529.66 transactions Changes in fair value of other equity 146,540,719.40 36,635,179.85 146,653,568.40 36,663,392.10 instruments Deductible difference arising from 107,474,309.53 16,149,104.44 77,872,943.63 11,933,224.52 share incentive expenses Changes in fair value of financial 7,298,819.37 1,234,418.76 6,918,505.67 1,158,336.82 assets held for trading Other deductible temporary difference 455,485,646.11 68,322,846.92 282,821,670.90 53,103,074.81 Total 3,443,039,110.33 533,861,743.26 3,217,520,901.38 552,542,866.71 Deferred tax liabilities: Changes in fair value of financial 20,269,315.67 3,216,065.39 19,970,547.94 3,215,329.05 assets held for trading Accelerated depreciation of fixed 1,094,571,545.41 167,757,444.03 752,180,706.08 114,114,492.09 assets Changes in fair value of other equity 242,925,303.81 39,399,916.06 359,110,036.65 70,405,084.25 instruments Unrealised gains from intra-company 105,940,000.00 20,791,000.00 105,940,000.00 20,791,000.00 transactions Total 1,463,706,164.89 231,164,425.48 1,237,201,290.67 208,525,905.39 (2) Deductible temporary differences and deductible tax losses of unrecognized deferred tax assets Item 2022.12.31 2021.12.31 Deductible temporary differences 239,109,485.46 175,707,417.84 Deductible tax loss 2,804,958,759.64 1,365,909,940.62 Total 3,044,068,245.10 1,541,617,358.46 (3) Expiry of deductible tax losses in subsequent period Year 2022.12.31 2021.12.31 Note 2022 0.00 129,386,282.40 2023 182,300,762.40 182,300,761.96 2024 385,139,111.62 385,138,859.92 2025 253,044,280.36 254,360,863.53 2026 390,203,263.39 389,994,598.37 2027 1,485,158,186.92 0.00 Non-expiry 109,113,154.95 24,728,574.44 Total 2,804,958,759.64 1,365,909,940.62 22. Other non-current assets 232 Joincare Pharmaceutical Group Annual Report 2022 Item 2022.12.31 2021.12.31 Term deposit and interests 812,562,286.58 52,127,500.00 VAT carry forward 3,338,552.19 56,384,552.60 Prepayment for acquisition of project 340,456,344.22 491,703,933.59 and equipment Prepayment for acquisition of technical 415,000.00 63,368,017.61 know-how Total 1,156,772,182.99 663,584,003.80 23. Short-term loans (1) Short-term loans by category Item 2022.12.31 2021.12.31 Unsecured loans 2,089,585,755.20 1,666,838,964.15 Guaranteed loans 36,464,859.86 851,645,870.94 Total 2,126,050,615.06 2,518,484,835.09 (2) The Company has no overdue short-term loans. 24. Financial liabilities held for trading Item 2022.12.31 2021.12.31 Financial liabilities held for trading 755,634.43 143,302.24 Including: Derivative financial liabilities 755,634.43 143,302.24 Total 755,634.43 143,302.24 Derivative financial liabilities represent foreign currency forward contracts. The loss from unexpired onerous contracts measured at fair value on balance sheet date was recognised as financial liabilities held for trading. 25. Notes payable Category 2022.12.31 2021.12.31 Bank acceptance bills 1,635,906,989.22 1,582,386,767.93 The Company has no overdue notes payable. 26. Accounts payable Item 2022.12.31 2021.12.31 Within one year 815,158,453.21 809,539,858.35 Over 1 year 128,747,127.70 62,013,352.16 Total 943,905,580.91 871,553,210.51 No significant accounts payable aging over 1 year at the end of the period. 27. Contract liabilities Item 2022.12.31 2021.12.31 Within one year 260,935,024.18 208,025,612.34 233 Joincare Pharmaceutical Group Annual Report 2022 Over 1 year 32,042,706.56 26,115,089.95 Total 292,977,730.74 234,140,702.29 No significant contract liabilities with ageing for more than 1 year at the end of the period. The amount of contract liabilities at beginning of the period recognised as revenue during the period is RMB188,045,099.86. 28. Employee benefits payables Item 2021.12.31 Increase Decrease 2022.12.31 Short-term employee benefits 473,806,357.40 2,179,864,994.17 2,082,528,146.47 571,143,205.10 Post-employment benefits - 341,723.80 146,280,117.93 146,037,217.37 584,624.36 Defined contribution plans Termination benefits 1,282,742.00 1,880,944.59 1,880,944.59 1,282,742.00 Total 475,430,823.20 2,328,026,056.69 2,230,446,308.43 573,010,571.46 (1) Short-term employee benefits Item 2021.12.31 Increase Decrease 2022.12.31 Salaries, bonus and allowances 325,123,978.13 1,788,026,844.16 1,738,082,893.10 375,067,929.19 Staff welfare 5,352,134.66 79,667,401.75 79,225,055.24 5,794,481.17 Social insurances 569,488.75 59,195,181.10 58,520,239.41 1,244,430.44 Including: 1. Medical insurance 467,562.91 54,244,259.70 53,558,791.79 1,153,030.82 2. Work injury insurance 62,711.37 3,046,821.43 3,058,209.96 51,322.84 3. Maternity insurance 39,214.47 1,904,099.97 1,903,237.66 40,076.78 Housing fund 1,493,719.88 60,105,695.76 59,375,841.16 2,223,574.48 Union funds and staff education 541,564.60 6,475,988.92 6,598,647.56 418,905.96 Stock Ownership Plan Special 140,725,471.38 186,393,882.48 140,725,470.00 186,393,883.86 Fund Total 473,806,357.40 2,179,864,994.17 2,082,528,146.47 571,143,205.10 (2) Defined contribution plans Item 2021.12.31 Increase Decrease 2022.12.31 Post-employment benefits 341,723.80 146,280,117.93 146,037,217.37 584,624.36 Including: 1. Basic pension 303,582.07 142,280,070.58 142,038,057.53 545,595.12 insurance 2. Unemployment insurance 38,141.73 4,000,047.35 3,999,159.84 39,029.24 Total 341,723.80 146,280,117.93 146,037,217.37 584,624.36 The Company participates in pension insurance and unemployment insurance plans established by the government in accordance with relevant requirements. According to the plans, the Company makes contributions to these plans in accordance with relevant requirements of the local government. Save for the above contributions, the Company no longer undertakes further payment obligation. The corresponding cost is charged to the profit or loss for the current period or the cost of relevant assets when it occurs. 29. Taxes payable Taxation 2022.12.31 2021.12.31 Value-added tax 166,151,353.61 91,860,518.74 234 Joincare Pharmaceutical Group Annual Report 2022 Taxation 2022.12.31 2021.12.31 Urban maintenance and construction tax 14,374,197.97 10,047,715.71 Enterprise income tax 124,039,899.44 145,106,168.70 Property tax 7,992,927.81 2,178,644.31 Land use tax 2,847,286.45 1,716,626.70 Individual income Tax 7,524,584.67 9,991,974.56 Stamp duty 2,904,260.39 676,792.62 Education surcharge 9,613,697.69 6,594,414.24 Others 2,254,065.70 2,445,327.83 Total 337,702,273.73 270,618,183.41 30. Other payables Item 2022.12.31 2021.12.31 Dividends payable 12,252,074.84 6,951,984.46 Other payables 3,668,082,286.04 3,285,456,005.33 Total 3,680,334,360.88 3,292,407,989.79 (1) Dividends payable Item 2022.12.31 2021.12.31 Common shares dividend 20,174.46 20,174.46 Qingyuan Xinbeijiang Enterprise (Group) Co., Ltd. 1,200,710.00 1,200,710.00 Other legal persons and individual shareholder of 6,682,964.50 3,311,300.00 subsidiaries Internal staff shareholders of subsidiaries 4,348,225.88 2,419,800.00 Total 12,252,074.84 6,951,984.46 (2) Other payables Item 2022.12.31 2021.12.31 Office expenses 69,513,003.38 66,603,733.56 Security deposits 89,750,329.22 85,316,947.15 Business promotion expenses 1,722,993,407.82 1,385,121,675.36 Technology transfer fee 10,000,000.00 10,000,000.00 Accrued expenses 1,714,076,189.32 1,696,272,218.54 Others 61,749,356.30 42,141,430.72 Total 3,668,082,286.04 3,285,456,005.33 The obligations of repurchasing restricted shares held by the directors, the senior management and their spouses amounted RMB0.00 at period end. Including, details of accrued expenses are as follow: Reason of Item 2022.12.31 2021.12.31 outstanding at year end 235 Joincare Pharmaceutical Group Annual Report 2022 Utility bill 28,378,759.70 23,611,733.95 Unpaid Research expenses 61,153,064.06 122,637,625.45 Unpaid Business development and 1,517,084,251.92 1,459,695,485.76 Unpaid promotion expenses Audit and information 4,775,560.70 4,893,299.88 Unpaid disclosure expenses Others 102,684,552.94 85,434,073.50 Unpaid Total 1,714,076,189.32 1,696,272,218.54 31. Non-current liabilities due within one year Item 2022.12.31 2021.12.31 Lease liabilities due within one year 19,415,779.34 21,295,233.00 Long-term loans and interest due within one year 43,661,481.64 70,280,833.33 Total 63,077,260.98 91,576,066.33 32. Other current liabilities Item 2022.12.31 2021.12.31 Output VAT pending for transfer 17,734,822.42 15,626,224.29 Payables for goods return 83,440,368.95 0.00 Others 101,522.98 0.00 Total 101,276,714.35 15,626,224.29 33. Long term loans Range of Range of Item 2022.12.31 2021.12.31 interest rate interest rate Unsecured loans 1,475,974,398.32 2.45%-3.20% 897,061,086.11 3.45%-3.70% Guaranteed loans 1,798,531,126.20 2.70%-3.60% 0.00 Subtotal 3,274,505,524.52 897,061,086.11 Less: Long-term loans due within one 43,661,481.64 70,280,833.33 year Total 3,230,844,042.88 826,780,252.78 34. Lease liabilities Item 2022.12.31 2021.12.31 Lease payments payable 42,898,265.42 46,367,027.32 Less: Lease liabilities due within one year 19,415,779.35 21,295,233.00 Total 23,482,486.07 25,071,794.32 Interest expenses accrued on lease liabilities within 2022 was RMB3.54 million, which was recorded in financial expenses-Interest expense. 35. Deferred income Reason of Item 2021.12.31 Increase Decrease 2022.12.31 formation Government grants 433,543,352.40 91,591,736.00 140,597,820.85 384,537,267.55 236 Joincare Pharmaceutical Group Annual Report 2022 Government grants recorded as deferred income refer to Note 62. Government grants. 36. Other non-current liabilities Item 2022.12.31 2021.12.31 The overall relocation and expansion project of 84,000,000.00 78,000,000.00 Sichuan Guangda Pharmaceutical Manufacturing 37. Share capital In year 2022 Movement in the year (+ or -) Item 2021.12.31 2022.12.31 Issue of new Conversion from Others Subtotal shares capital reserve I. Tradable shares subject to selling restrictions 1. Domestic legal person shares 0 0 0 0 0 0 2. Domestic natural person shares 0 0 0 0 0 0 3. Overseas legal person shares 0 0 0 0 0 0 Tradable shares subject to selling 0 0 0 0 0 0 restrictions in aggregate II. Tradable shares 0 0 1. Ordinary shares denominated in 1,907,727,908 72,421,134 0 -50,959,668 21,461,466 1,929,189,374 RMB 2. Domestically listed foreign shares 0 0 0 0 0 0 Tradable shares in aggregate 1,907,727,908 72,421,134 0 -50,959,668 21,461,466 1,929,189,374 III. Total number of shares 1,907,727,908 72,421,134 0 -50,959,668 21,461,466 1,929,189,374 The increase in the year: 1. The company issued 6,382,500 GDRs on the Swiss Stock Exchange, representing 63,825,000 A shares; 2. An increase of 8,596,134 shares due to the exercise of stock options The reduction of share capital in this period is cancellation of repurchased shares. In year 2021 Movement in the year (+ or -) Item 2020.12.31 Conversion 2021.12.31 Issue of new from capital Others Subtotal shares reserve I. Tradable shares subject to selling restrictions 1. Domestic legal person shares 0 0 0 0 0 0 2. Domestic natural person shares 0 0 0 0 0 0 3. Overseas legal person shares 0 0 0 0 0 0 Tradable shares subject to selling 0 0 0 0 0 0 restrictions in aggregate II. Tradable shares 1. Ordinary shares denominated in 1,952,780,764 10,082,440 0 -55,135,296 -45,052,856 1,907,727,908 RMB 2.Domestically listed foreign shares 0 0 0 0 0 0 Tradable shares in aggregate 1,952,780,764 10,082,440 0 -55,135,296 -45,052,856 1,907,727,908 III. Total number of shares 1,952,780,764 10,082,440 0 -55,135,296 -45,052,856 1,907,727,908 The increase in share capital in this period was due to issue of new shares and the decrease in share capital in this period was due to cancellation of repurchased shares. 237 Joincare Pharmaceutical Group Annual Report 2022 38. Capital reserve In year 2022 Item 2021.12.31 Increase Decrease 2022.12.31 Capital premium 2,152,860,227.84 642,189,404.23 573,367,347.30 2,221,682,284.77 Other capital reserve 112,497,084.08 30,762,735.61 21,248,888.47 122,010,931.22 Total 2,265,357,311.92 672,952,139.84 594,616,235.77 2,343,693,215.99 The increase in capital premium was due to: 1. The Company's stock options were exercised for 8,596,134 shares, increasing the capital premium by RMB62,519,504.79, and correspondingly accrued share incentive expenses of RMB4,975,185 which were transferred from other capital reserve to capital premium. 2. The exercise of share options of the Company’s subsidiary, Livzon Group, increasing the capital premium of RMB14,645,670.47 according to shareholding held by the Company, and correspondingly accrued share incentive expenses of RMB9,019,288.61 which were transferred from other capital reserve to capital premium. 3. After the stock options are exercised, the difference between the tax deductible expenses according to tax regulations and the accrued expenses reduces the income tax payable by RMB1,347,279.67, which increased the share premium accordingly. 4. The Company issues GDRs on the Swiss Stock Exchange, increasing the capital reserve by RMB549,682,475.69. The decrease in capital premium was due to: The Company and its subsidiary, Livzon Group, cancelled the repurchased shares, the capital premium is reduced by RMB573,367,347.30. The increase in other capital reserve was due to: 1. The Company and its subsidiary, Livzon Group, accrued share incentive expenses RMB24,733,974.70. 2. The Company’s subsidiary, Livzon Group, made non- proportional capital contribution to an investee under equity accounting method that led to change in shareholding ratio and other equity, the capital reserve is increased by RMB6,028,760.91. The decrease in other capital reserve was due to: 1. The exercise of share incentive by the Company’s subsidiary, Livzon Group, caused the changes in the shareholding held by the Company and led to the change in other equity, the capital reserve is decreased by RMB7,254,414.86. 2. Transfer of share incentive expenses to capital premium of RMB13,994,473.61. In year 2021 Item 2020.12.31 Increase Decrease 2021.12.31 Capital premium 2,531,019,936.35 369,115,622.89 747,275,331.40 2,152,860,227.84 Other capital reserve 2,268,737.93 114,769,391.67 4,541,045.52 112,497,084.08 Total 2,533,288,674.28 483,885,014.56 751,816,376.92 2,265,357,311.92 Reasons for increase in capital premium: 1) 10,082,440 shares of the Company's stock options were exercised, increasing the capital premium by RMB72,493,116.59, and the corresponding accrued share incentive fee of RMB1,457,178.93 was transferred from other capital reserves to the capital premium; 2) The Company's subsidiary Livzon's stock options are exercised, according to the shareholding ratio of the Company, the corresponding increase in the share capital premium of RMB88,109,304.98, and the corresponding accrued equity incentive expenses of RMB3,083,866.59 are transferred from other capital reserves to the share capital premium; 3) After the exercise of stock options, the difference between the tax deductible expenses and the previous accrued expenses resulted in a reduction of income tax payable by RMB13,609,184.27, and the share capital premium was increased accordingly; 4) Since the overseas financing of the subsidiary Livzon is transferred into the Mainland China and thus the reduction of capital of the subsidiaries are not in the same proportion, the difference between the share of net assets of the subsidiaries owned by the Company before and after the reduction of capital caused the increase in capital premium by RMB190,362,971.53. The decrease in share capital premium of RMB747,275,331.40 for the period was due to the cancellation of shares repurchased by the Company and the subsidiary Livzon Group. 238 Joincare Pharmaceutical Group Annual Report 2022 Reasons for increase in other capital reserves: 1) Share incentive expenses accrued by the Company and the subsidiary Livzon Group was RMB11,652,295.42; 2) The subsidiary Livzon Group's equity method accounting investment increased capital in different proportions, resulting in changes in the shareholding ratio held by the Company and changes in other equity instrument investment, so this caused the capital reserve increased by RMB35,846,098.47. 3) The exercise of the stock options of the incentive plan and repurchase of shares of the subsidiary Livzon Group lead to changes in the Company's shareholding ratio and changes in other equity instrument investment, so this caused the capital reserve decreased by RMB55,295,829.27; 4) As the Company disposed of subsidiaries, the capital reserve of RMB11,975,168.51 transferred to profit or loss for this period. Other capital reserves decreased as the equity incentive expenses of RMB4,541,045.52 was transferred to the capital premium. 39. Treasury shares In year 2022 Item 2021.12.31 Increase Decrease 2022.12.31 Repurchase of shares due to Share Ownership Scheme and Share Options 222,644,454.50 0.00 0.00 222,644,454.50 Incentive Scheme Repurchase of shares to be cancelled 0.00 724,513,822.62 599,981,715.83 124,532,106.79 Total 222,644,454.50 724,513,822.62 599,981,715.83 347,176,561.29 The increase in treasury shares in the period is the total amount of funds used by the Company to repurchase 61,916,903 shares of the Company through centralized bidding transactions. The reduction of treasury shares in this period is: Cancellation of repurchased shares. In year 2021 Item 2020.12.31 Increase Decrease 2021.12.31 Repurchase of shares due to Share Ownership Scheme and Share Options 253,637,154.50 0.00 30,992,700.00 222,644,454.50 Incentive Scheme Repurchase of shares to be cancelled 0.00 699,900,526.87 699,900,526.87 0.00 Total 253,637,154.50 699,900,526.87 730,893,226.87 222,644,454.50 The decrease was due to the transfer to the stock ownership plan account for the current employee stock ownership plan and shares incentive. The change of repurchase of shares to be cancelled: The increase in treasury shares in this period is the total amount of funds used by the Company to repurchase 55,135,296 shares of the Company through centralized bidding transactions. The decrease in treasury shares was the cancellation of repurchase shares. 40. Other comprehensive income In year 2022 Current year Less: 2021.12.31 transferred to Amount Amount 2022.12.31 Item profit or loss attributable attributable (1) Amount before Less: Income (3) =(1) +(2) in current to parent to minority tax tax expenses year or company interests after retained after tax(2) tax earnings I. Other comprehensive income not reclassified into 102,556,982.18 37,438,265.00 89,722,066.22 -1,303,488.43 -85,577,350.31 34,597,037.52 16,979,631.87 profit or loss subsequently 1.Other comprehensive income not reclassified to profit or loss 6,658,847.65 4,723,927.54 0.00 0.00 2,116,352.61 2,607,574.93 8,775,200.25 under equity method 239 Joincare Pharmaceutical Group Annual Report 2022 2.Changes in fair value of other equity instrument 95,898,134.53 32,714,337.46 89,722,066.22 -1,303,488.43 -87,693,702.91 31,989,462.58 8,204,431.61 investments II. Other comprehensive income that will be -97,169,436.20 125,587,048.18 0.00 0.00 84,894,277.87 40,692,770.31 -12,275,158.33 reclassified into profit or loss subsequently 1.Other comprehensive income that will be transferred 37,989.91 527,718.52 0.00 0.00 236,421.59 291,296.93 274,411.50 to profit or loss under equity method 2.Translation difference of foreign currency financial -97,207,426.12 125,059,329.66 0.00 0.00 84,657,856.28 40,401,473.38 -12,549,569.84 statements Total other comprehensive 5,387,545.97 163,025,313.18 89,722,066.22 -1,303,488.43 -683,072.44 75,289,807.82 4,704,473.53 income In year 2021 Current year Less: 2020.12.31 transferred to Amount Amount 2021.12.31 Item profit or loss attributable to attributable to (1) Amount Less: Income (3) =(1) +(2) in current parent minority before tax tax expenses year or company after interests after retained tax(2) tax earnings I. Other comprehensive income not reclassified into 180,616,463.38 43,382,751.21 171,926,789.47 2,196,770.08 -78,059,481.21 -52,681,327.13 102,556,982.18 profit or loss subsequently 1.Other comprehensive income not reclassified to profit or loss 0.00 14,820,196.44 0.00 0.00 6,658,847.65 8,161,348.794 6,658,847.65 under equity method 2.Changes in fair value of other 180,616,463.38 28,562,554.77 171,926,789.47 2,196,770.08 -84,718,328.85 -60,842,675.92 95,898,134.53 equity instrument investments II. Other comprehensive income that will be -64,315,904.10 -46,945,392.92 0.00 0.00 -32,853,532.10 -14,091,860.81 -97,169,436.20 reclassified into profit or loss subsequently 1.Other comprehensive income that will be transferred 51,589.71 -30,268.270 0.00 0.00 -13,599.80 -16,668.468 37,989.91 to profit or loss under equity method 2.Translation difference of - - foreign currency financial -64,367,493.82 0.00 0.00 -32,839,932.30 -97,207,426.12 46,915,124.650 14,075,192.346 statements Total other comprehensive - - 116,300,559.28 -3,562,641.71 171,926,789.47 2,196,770.08 5,387,545.97 income 110,913,013.31 66,773,187.941 41. Surplus reserve In year 2022 Item 2021.12.31 Increase Decrease 2022.12.31 Statutory surplus 599,506,581.71 93,945,402.42 0.00 693,451,984.13 reserve Discretionary surplus 40,210,642.44 0.00 0.00 40,210,642.44 reserve Reserve funds 1,103,954.93 0.00 0.00 1,103,954.93 Total 640,821,179.08 93,945,402.42 0.00 734,766,581.50 In year 2021 Item 2020.12.31 Increase Decrease 2021.12.31 Statutory surplus 474,626,867.82 124,879,713.89 0.00 599,506,581.71 reserve Discretionary surplus 40,210,642.44 0.00 0.00 40,210,642.44 reserve Reserve funds 1,103,954.93 0.00 0.00 1,103,954.93 Total 515,941,465.19 124,879,713.89 0.00 640,821,179.08 42. Undistributed profits 240 Joincare Pharmaceutical Group Annual Report 2022 (1) Movement of undistributed profits 2022 2021 Appropriat Item ion ratio Retained earnings in previous period before 7,223,644,166.22 6,231,451,582.26 -- adjustments Adjustments to opening balance of retained earnings 0.00 0.00 -- (increase +, decrease -) Opening balance of retained earnings after adjustments 7,223,644,166.22 6,231,451,582.26 Add: Net profit attributable to parent company for the 1,502,595,840.48 1,328,499,432.05 -- current year Gains from disposal of other equity instruments 101,906,354.19 77,248,253.85 -- investment Less: Appropriation of statutory surplus reserve 93,945,402.42 124,879,713.89 10% Appropriation of discretionary surplus reserve 0.00 0.00 Appropriation for dividends to ordinary shares 277,557,631.65 288,675,388.05 Dividend to ordinary shares converted to share 0.00 0.00 capital Closing balance of undistributed profits 8,456,643,326.82 7,223,644,166.22 (2) Profit distributions Unit: RMB Item 2022 2021 Dividends: 2021 year-end dividend (Note 2) 277,557,631.65 0.00 2020 year-end dividend (Note 3) -- 288,675,388.05 Dividends proposed after the balance sheet date: 2022 year-end dividend (Note 1) 0.00 0.00 2021 year-end dividend (Note 2) 277,557,631.65 Note 1: On 27 April 2023, the twenty-third meeting of the eighth board of directors of the Company passed the 2022 annual profit distribution plan. A cash dividend of RMB1.80 (tax inclusive) for every 10 shares would be distributed to all shareholders based on the Company's total share capital, deducted by the repurchased shares held in the Company's special securities account, on the equity registration date determined by the implementation of the Company's 2022 annual profit distribution plan. The remaining undistributed profits are carried forward for distribution in future years. Note 2: On 29 March 2022, the ninth meeting of the eighth board of directors of the Company passed the 2021 annual profit distribution plan. A cash dividend of RMB1.50 (tax inclusive) for every 10 shares would be distributed to all shareholders based on the Company's total share capital, deducted by the repurchased shares held in the Company's special securities account, on the equity registration date determined by the implementation of the Company's 2021 annual profit distribution plan. The remaining undistributed profits are carried forward for distribution in future years. Note 3: According to the "Profit Distribution Plan for 2020 of the Company" approved by the Company's 2020 Annual General Meeting of Shareholders on 21 May 2021, the Company distributed cash dividends to all shareholders, RMB0.15 per share, based on the 1,924,502,587 shares, which was calculated by the 1,958,593,217 issued shares registered in China Securities Depository and Clearing Corporation Limited (Shenzhen Branch) on 24 June 2020 with deduction of 34,090,630 repurchased shares held in repurchased account, the total amount was RMB288,675,388.05. 43. Operating income and operating cost 241 Joincare Pharmaceutical Group Annual Report 2022 (1) Operating income and operating cost 2022 2021 Item Revenue Cost Revenue Cost Primary operations 17,012,733,738.86 6,160,330,584.19 15,746,624,848.53 5,604,702,296.12 Other operations 130,019,329.96 91,934,724.21 157,063,418.06 111,591,591.46 Total 17,142,753,068.82 6,252,265,308.40 15,903,688,266.59 5,716,293,887.58 (2) Primary Disaggregate information of operating income ① Segregation by products 2022 2021 Item Revenue Cost Revenue Cost chemical active pharmaceutical ingredients (APIs) and 5,229,641,907.04 3,409,781,896.55 4,690,255,375.73 3,184,889,165.53 intermediates (化学原 料药及中间体) Chemical pharmaceuticals (化学 9,226,385,569.43 1,813,969,087.68 8,876,919,296.64 1,753,573,833.73 药物) Traditional Chinese 1,296,583,761.24 427,894,665.07 1,109,344,037.45 295,328,306.33 medicine (中药制剂) Biological products (生 408,488,131.90 106,811,638.64 225,756,503.31 15,987,958.28 物制品) Health care products 121,235,545.22 46,223,021.02 115,164,422.30 33,652,500.02 (保健食品) Diagnostic reagents and equipment (诊断试剂及 723,535,115.00 352,636,503.06 723,917,736.81 319,168,131.72 设备) Others 102,352.31 263,529.90 254,849.67 328,336.21 Subtotal of 17,005,972,382.14 6,157,580,341.92 15,741,612,221.92 5,602,928,231.82 pharmaceutical industry Service industry 6,761,356.72 2,750,242.27 5,012,626.61 1,774,064.30 Total 17,012,733,738.86 6,160,330,584.19 15,746,624,848.53 5,604,702,296.12 ② Segregation by operating location 2022 2021 Item Revenue Cost Revenue Cost Domestic 14,170,771,017.92 4,326,229,111.25 13,175,044,906.28 3,837,751,076.40 Overseas 2,841,962,720.94 1,834,101,472.94 2,571,579,942.25 1,766,951,219.72 Total 17,012,733,738.86 6,160,330,584.19 15,746,624,848.53 5,604,702,296.12 ③ Segregation by timing of revenue recognition 2022 2021 Item Revenue Cost Revenue Cost Commodities (Recognized at a point 17,012,733,738.86 6,160,330,584.19 15,746,624,848.53 5,604,702,296.12 in time) 242 Joincare Pharmaceutical Group Annual Report 2022 ④ Information of top five customers of business revenue Total operating revenue from top five Proportion to primary operating income in Period customers the period (%) 2022 1,524,490,064.48 8.96 2021 1,372,032,796.69 8.71 ⑤ Segregation by other operations 2022 2021 Item Revenue Cost Revenue Cost Sale of raw materials 47,190,775.25 31,174,586.16 50,440,716.79 40,772,550.07 Processing fee 5,995,904.44 2,546,785.48 6,794,908.37 1,660,944.94 Rental fees 10,731,614.42 405,023.12 9,381,937.42 112,497.34 Power fee 11,028,103.39 10,220,631.76 11,855,332.16 11,464,416.78 Others 55,072,932.46 47,587,697.69 78,590,523.32 57,581,182.33 Total 130,019,329.96 91,934,724.21 157,063,418.06 111,591,591.46 44. Taxes and surcharges Item 2022 2021 Urban construction tax 86,745,317.20 78,915,243.23 Education surcharge 64,105,649.70 57,919,345.89 Land use tax 10,656,172.45 9,853,262.81 Property tax 24,496,501.64 22,448,547.60 Stamp duty and others 13,742,716.57 13,680,250.49 Total 199,746,357.56 182,816,650.02 Note: The bases of calculations for major taxes and surcharges are set out in Note IV. Taxation. 45. Selling expenses Item 2022 2021 Marketing and promotional expenses 4,372,087,623.70 4,477,764,584.15 Staff salaries 456,875,210.86 397,170,070.40 Entertainment and travel expenses 50,363,363.02 65,297,664.11 Conference fees 13,696,783.94 23,554,731.43 Others 57,779,474.64 63,025,095.32 Total 4,950,802,456.16 5,026,812,145.41 46. Administrative expenses Item 2022 2021 Staff salaries 570,458,570.31 458,139,486.90 Depreciation and amortisation 113,223,517.86 118,237,699.36 Loss on suspension of operations 0.00 67,730,993.25 243 Joincare Pharmaceutical Group Annual Report 2022 Share incentive expenses 56,241,342.12 27,642,491.39 Advisory, consultancy and information disclosure fees 22,074,505.08 28,176,640.22 Quality project expenses 29,400,960.89 46,075,518.11 Office, entertainment and travelling expenses 59,419,007.80 60,231,705.78 Repair of utilities, transportation and miscellaneous expenses 32,266,815.31 41,571,843.51 Recruitment and staff training expenses 10,962,130.33 10,648,299.29 Others 98,436,741.81 80,798,766.52 Total 992,483,591.51 939,253,444.33 47. Research and development expenses Item 2022 2021 Material costs 290,480,597.96 289,853,404.42 Staff salaries 429,267,039.97 399,459,964.18 Share incentive expenses 835,636.96 6,884,591.21 Testing fees 597,331,039.56 434,694,547.02 Depreciation and amortisation 274,454,884.02 130,493,088.54 Acquired Technology 0.00 7,318,927.47 Others 149,718,881.47 128,426,750.49 Total 1,742,088,079.94 1,397,131,273.33 48. Financial expenses Item 2022 2021 Interest expense 139,016,104.44 90,278,042.69 Less: Interest income 395,476,309.66 191,964,051.82 Exchange gain or loss -104,462,941.41 2,737,152.59 Bank charges and others 8,475,722.01 6,054,104.82 Total -352,447,424.62 -92,894,751.72 49. Other income Related to assets/ Item 2022 2021 Related to income Government grants 132,272,375.37 59,110,913.13 Related to assets Government grants 154,570,556.96 186,224,227.56 Related to income Handling fees for tax withholding 3,025,074.11 2,011,794.27 Total 289,868,006.44 247,346,934.96 For specific information on government grants, please refer to Note V. 62. Government grants for details. 50. Investment income Item 2022 2021 Long-term equity investments income under equity method 70,577,657.04 10,281,021.59 244 Joincare Pharmaceutical Group Annual Report 2022 Investment income from disposal of long-term equity investments 4,242,404.46 -9,552,139.31 Investment income from financial assets held for trading during the 2,421,216.08 306,526.30 holding period Dividend income from other equity instrument investments 18,713,637.23 37,114,395.95 Investment income from disposal of financial assets held for 31,616,770.34 -37,867,110.74 trading Total 55,973,114.29 71,881,264.65 51. Gains from changes in fair value Source of gains from changes in fair value 2022 2021 Financial assets held for trading -75,650,657.64 -23,363,035.92 Including: Debt instruments investment -5,873.00 30,410.89 Equity instruments investment -73,700,967.89 -17,702,179.18 Derivative financial assets -1,943,816.75 -5,691,267.63 Financial liabilities held for trading -612,332.19 -143,090.17 Including: Derivative financial liabilities -612,332.19 -143,090.17 Total -76,262,989.83 -23,506,126.09 52. Credit impairment loss (“-” for loss) Item 2022 2021 Bad debts of accounts receivable -2,978,050.82 -9,189,454.14 Bad debts of other receivables -1,145,692.55 1,165,341.94 Total -4,123,743.37 -8,024,112.20 53. Assets impairment loss (“-” for loss) Item 2022 2021 Decline in value of inventories -120,646,933.39 -61,759,256.42 Impairment loss of fixed assets -186,548.38 -1,191,722.30 Impairment loss of intangible assets -3,207,819.01 0.00 Impairment loss of construction in progress -11,068,266.54 0.00 Impairment loss of development costs -7,518,369.12 0.00 Total -142,627,936.44 -62,950,978.72 54. Gains from disposal of assets Item 2022 2021 Gain from disposal of fixed assets (“-” for Loss) -705,357.30 6,780,989.95 Gain from disposal of intangible assets (“-” for Loss) 0.00 17,263,196.60 Total -705,357.30 24,044,186.55 55. Non-operating income 245 Joincare Pharmaceutical Group Annual Report 2022 Amount included in Item 2022 2021 non-recurring gains and losses Gains on destruction or retirement of non- 520,860.40 631,652.20 520,860.40 current assets Income from scraps 2,478,956.98 3,106,514.85 2,478,956.98 Compensation income 542,762.41 890,504.89 542,762.41 Waiver of payables 2,671,703.10 891,816.68 2,671,703.10 Others 2,015,564.68 3,121,342.24 2,015,564.68 Total 8,229,847.57 8,641,830.86 8,229,847.57 56. Non-operating expenses Amount included in non- Item 2022 2021 recurring gains and losses Donation expenses 12,116,987.32 29,101,247.20 12,116,987.32 Loss on retirement of non-current assets 17,045,450.21 7,057,428.39 17,045,450.21 Others 2,898,248.53 3,220,598.10 2,898,248.53 Total 32,060,686.06 39,379,273.69 32,060,686.06 57. Income tax expenses (1) Details of income tax expenses Item 2022 2021 Current income tax 489,730,614.81 375,813,164.01 Deferred income tax 72,278,243.88 -36,332,858.72 Total 562,008,858.69 339,480,305.29 (2) Reconciliation between income tax expenses and accounting profits: Item 2022 2021 Profit before tax 3,456,104,955.17 2,952,329,343.96 Income tax expenses calculated at legal/applicable tax rate 864,026,238.79 738,082,335.99 Effect of different tax rates applicable to subsidiaries 7,219,165.25 -157,284.13 Effect of tax reduction and exemption -608,357,224.56 -461,501,254.72 Effect of non-deductible costs, expenses and losses -1,338,352.12 11,222,334.85 Effect of deductible tax losses for which no deferred tax assets -1,400,449.92 -1,262,016.75 were recognised in prior periods Effect of deductible tax losses or deductible temporary differences for which no deferred tax asset was recognised in the current 237,204,163.65 91,064,540.85 period Others 64,655,317.60 -37,968,350.80 Income tax expenses 562,008,858.69 339,480,305.29 58. Notes to cash flows statement (1) Other cash received relating to operating activities Item 2022 2021 246 Joincare Pharmaceutical Group Annual Report 2022 Government grants 239,196,300.96 231,492,540.63 Interest income 324,250,238.72 177,822,721.68 Recovery of employee loans 7,299,222.31 8,237,323.25 Security deposits 67,623,532.89 75,737,734.89 Compensation received 1,175,630.74 83,043.02 Current accounts and others 44,100,808.77 51,664,073.17 Total 683,645,734.39 545,037,436.64 (2) Other cash paid relating to operating activities Item 2022 2021 Office Expenses 97,503,048.97 98,749,129.18 Travel expenses 30,372,654.60 69,905,127.66 Business entertainment expenses 69,811,587.72 84,266,002.56 Freight expenses 50,691,409.60 107,473,996.66 advertising fee 630,941.00 3,789,481.18 Conference fees 17,972,567.21 34,011,851.22 Agency and consulting services fees 35,039,742.74 43,892,772.99 R&D expenses 808,023,085.72 756,535,241.25 Bank charges 7,927,848.89 5,874,566.03 Petty cash 510,948.05 1,008,235.84 Business promotion expenses 4,634,065,689.94 4,832,518,720.60 Letter of credit and bank acceptance deposit 1,676,708.15 33,459,360.54 Other expenses paid and current accounts 157,458,032.58 214,400,075.57 Total 5,911,684,265.17 6,285,884,561.28 (3) Other cash received relating to investing activities Item 2022 2021 Structured Deposits and Term Deposits 0.00 100,000,000.00 Security deposits 7,405,431.82 12,557,736.54 Compensation for demolition 6,000,000.00 0.00 Withdrawal of Treasury bonds and margin 158,470.77 1,013,650.67 Others 0.00 2,700.00 Total 13,563,902.59 113,574,087.21 (4) Other cash paid relating to investing activities Item 2022 2021 Fixed deposits 1,084,392,104.38 50,000,000.00 Security deposits 5,755,128.00 235,000.00 Foreign exchange forward contract losses 30,021,080.39 2,831,260.72 Others 150.00 3,779.69 Total 1,120,168,462.77 53,070,040.41 247 Joincare Pharmaceutical Group Annual Report 2022 (5) Other cash received relating to financing activities Item 2022 2021 Equity Transfer fee paid to Guosen Securities Employee 0.00 30,992,700.00 Stock Ownership Plan Account Collection and advance payment of individual income 6,859,477.42 347,182.11 tax Discount of acceptance bills 380,719,088.50 0.00 Total 381,066,270.61 37,852,177.42 (6) Other cash paid relating to financing activities Item 2022 2021 Repurchase of shares 780,551,259.85 938,084,088.14 Capital reduction in minority interests in subsidiary 0.00 324,225,000.00 Rental payments 32,925,995.59 27,862,261.10 Collection and advance payment of individual income 1,237,210.80 1,716,145.57 tax Dividend handling fee 0.00 152,691.48 GDRs issuance fees 16,003,722.82 0.00 Others 624,000.00 0.00 Total 831,342,189.06 1,292,040,186.29 59. Supplement to cash flow statement (1) Supplement to cash flow statement Supplement information 2022 2021 1. Reconciliation of net profit to cash flow from operating activities: Net profit 2,894,096,096.48 2,612,849,038.67 Add: Assets impairment loss 142,627,936.44 62,950,978.72 Credit impairment loss 4,123,743.37 8,024,112.20 Depreciation of fixed assets 615,224,869.47 540,627,410.92 Amortisation of right-of-use assets 32,367,074.98 26,000,791.57 Amortization of intangible assets 190,110,160.68 53,826,067.53 Long-term prepaid expenses amortization 58,054,847.07 43,989,121.05 Losses on disposal of fixed assets, intangible assets and other long- -24,044,186.55 705,357.30 term assets (Gain as in “-”) Loss on retirement of fixed assets (Gain as in “-”) 16,524,589.81 6,425,776.19 Losses on changes in fair value (Gain as in “-”) 76,262,989.83 23,506,126.09 Financial expenses (Gain as in “-”) 28,611,954.30 100,946,504.76 Investment losses (Gain as in “-”) -55,973,114.29 -71,881,264.65 Decrease in deferred tax assets (Increase as in “-”) 18,519,526.08 -75,082,337.68 Increase in deferred tax liabilities (Decrease as in “-”) 53,643,688.28 28,755,973.72 248 Joincare Pharmaceutical Group Annual Report 2022 Supplement information 2022 2021 Decrease in inventories (Increase as in “-”) -604,732,283.55 -306,334,662.14 Decrease in operating receivables (Increase as in “-”) 2,380,941,083.00 -1,593,686,129.41 Increase in operating payables (Decrease as in “-”) -1,924,536,232.01 1,036,581,635.58 Others 51,132,852.05 89,634,088.67 Net cash flows from operating activities 3,977,705,139.29 2,563,089,045.24 2. Significant investment or finance activities not involving cash: Conversion of debt into capital 0.00 0.00 Convertible bonds mature within one year 0.00 0.00 Fixed assets acquired under finance leases 0.00 0.00 3. Net increase / (decrease) in cash and cash equivalents: Cash and bank balance as at end of year 14,178,465,686.40 11,697,518,141.18 Less: cash and bank balance at beginning of year 11,697,518,141.18 12,122,781,311.49 Add: cash equivalents at end of year 0.00 0.00 Less: cash equivalents at beginning of year 0.00 0.00 Net increase in cash and cash equivalents 2,480,947,545.22 -425,263,170.31 (2) Net cash paid for acquisition of subsidiaries during the year None. (3) Net cash received from disposal of subsidiaries during the year None. (4) Details of cash and cash equivalents Item 2022 2021 I. Cash 14,178,465,686.40 11,697,518,141.18 Including: Cash on hand 231,883.95 225,179.98 Cash at bank readily available for payment 14,164,236,988.28 11,554,754,721.43 Other monetary fund readily available for payment 13,996,814.17 142,538,239.77 II. Cash equivalents 0.00 0.00 Including: bonds investment mature within 3 months 0.00 0.00 III. Cash and cash equivalents as at closing balance 14,178,465,686.40 11,697,518,141.18 Cash and cash equivalents do not include any cash and cash equivalents that are restricted in use. 60. Ownership or using rights of assets subject to restriction Carrying value at Item Reason of restriction year end Security deposits of letters of credit, bank acceptance bills Other monetary funds 1,392,407.76 and forward settlement Notes receivable 469,659,266.19 Bills pool business, pledge notes receivable Total 471,051,673.95 61. Items in foreign currencies 249 Joincare Pharmaceutical Group Annual Report 2022 Balance in foreign currency Equivalent RMB balance at year Item Conversion rate at year end end Cash and bank balances Including: HKD 771,333,142.89 0.89327 689,008,756.54 Euro 94,684.76 7.4229 702,835.51 USD 257,758,337.95 6.9646 1,795,183,720.46 MOP 4,921,985.97 0.8681 4,272,776.02 JPY 344,798,878.00 0.052358 18,052,979.65 GBP 1,940.10 8.3941 16,285.40 Accounts receivable Including: USD 71,530,369.45 6.9646 498,180,411.07 MOP 1,264,788.45 0.8681 1,097,962.85 Other receivables Including: USD 21.21 6.9646 147.72 HKD 3,189,409.63 0.89327 2,849,003.94 MOP 581,188.00 0.8681 504,529.30 Other current assets Including: USD 13,326,786.67 6.9646 92,815,738.44 Short-term loans Including: USD 1,933,328.53 6.9646 13,464,859.86 Accounts payable Including: USD 512,475.01 6.9646 3,569,183.45 Euro 5,665.41 7.4229 42,053.77 JPY 279,370,752.84 0.052358 14,627,293.88 Swiss Franc 18,810.00 7.5432 141,887.59 Other payables Including: HKD 2,892,127.05 0.89327 2,583,450.33 USD 4,015,670.14 6.9646 27,967,536.26 62. Government grants (1) Government grants recorded as deferred income and measured at gross amount method subsequently Item Related to Additions in the Transfer to profit Other presented in assets/ Projects with grants Category Beginning balance Closing balance year or loss movement income Related to statement income Laboratory project of respiratory system inhalation preparation engineering Financial Related to 3,501,550.00 0.00 1,616,100.00 0.00 1,885,450.00 Other income allocation assets laboratory project (呼吸系统 吸入制剂工程实验室项目) Construction of a recycling production base for carbapenem products (碳青霉 Financial Related to 3,625,000.00 0.00 0.00 0.00 3,625,000.00 Other income allocation assets 烯类系列产品循环化生产基 地建设) 250 Joincare Pharmaceutical Group Annual Report 2022 Item Related to Additions in the Transfer to profit Other presented in assets/ Projects with grants Category Beginning balance Closing balance year or loss movement income Related to statement income Construction of an integrated production line for fully automatic blister-type dry powder inhalant micro-filling Financial Related to 927,666.66 0.00 242,000.04 0.00 685,666.62 Other income and winding (全自动泡罩型 allocation assets 干粉吸入剂微量灌封与卷绕 一体化生产线建设) Change in National Science and Technology Major Project* Research funding for lipid injection * Baiyunshan Financial Related to 150,000.00 0.00 150,000.00 0.00 0.00 Other income Hanfang transfer (国家重大 allocation assets 专项项目变更*注射脂质研 究经费*白云山汉方转入) Research on common key technologies for the large- scale development of new Financial Related to inhalation preparations (新型 365,700.00 0.00 365,700.00 0.00 0.00 Other income allocation assets 吸入制剂规模化发展共性关 键技术研究) 2021 Shenzhen Sponge City Construction Fund Award*Shenzhen Water Financial Related to Affairs Bureau (2021 年度深 0.00 895,232.00 134,284.80 0.00 760,947.20 Other income allocation assets 圳市海绵城市建设资金奖励 *深圳市水务局) Large-scale development subsidy for new inhalation Financial Related to 2,262,600.00 0.00 582,600.00 0.00 1,680,000.00 Other income preparations (新型吸入制剂 allocation assets 规模化发展补助) Project Subsidy of Marine mollusk kinetic protein (海洋 Financial Related to 23,840,000.00 0.00 19,562,000.00 0.00 4,278,000.00 Other income 软体动物动能蛋白项目补 allocation assets 助) New inhalation drug formulation creation project Financial Related to 67,248,400.00 6,349,500.00 52,689,525.12 0.00 20,908,374.88 Other income (新型吸入给药制剂创制项 allocation assets 目) Zhimu total sapogenin project Financial Related to 8,900,000.00 0.00 0.00 0.00 8,900,000.00 Other income (知母总皂甙元项目) allocation assets Glucocorticoid inhalation Financial Related to suspension project (糖皮质混 3,600,000.00 3,600,000.00 0.00 0.00 7,200,000.00 Other income allocation assets 悬液项目) Government funding for small molecule peptide project (政 Financial Related to 319,999.80 0.00 80,000.04 0.00 239,999.76 Other income allocation assets 拨款用于小分子肽项目) Leulu total sterone project (漏 Financial Related to 2,500,000.00 0.00 0.00 0.00 2,500,000.00 Other income 芦总甾酮项目) allocation assets R&D of active substances with bone and joint repair and health care functions(具有 Financial Related to 957,649.92 0.00 119,706.24 0.00 837,943.68 Other income allocation assets (骨关节修复与保健) 功能的 活性物质研发) Key technology research and development of budesonide nebulized inhalation solution Financial Related to 2,508,333.33 0.00 350,000.04 0.00 2,158,333.29 Other income allocation assets (布地奈德雾化吸入溶液关 键技术研发) Return of land holding tax (土 Financial Related to 3,567,661.42 0.00 107,029.80 0.00 3,460,631.62 Other income 地使用税返还) allocation assets Subsidies for the development of pharmaceutical APIs Financial Related to 40,741,354.94 0.00 1,219,192.68 0.00 39,522,162.26 Other income industry (医药原料药行业发 allocation assets 展支持资金补助) Innovation coupon (Jingjin Financial Related to filter press equipment) (创新 233,332.79 0.00 80,000.04 0.00 153,332.75 Other income allocation assets 券(景津压滤设备) ) Xinxiang High-tech Project Financial Related to Fund Support (新乡高新技术 1,861,111.08 0.00 56,397.36 0.00 1,804,713.72 Other income allocation assets 项目资金扶持) 251 Joincare Pharmaceutical Group Annual Report 2022 Item Related to Additions in the Transfer to profit Other presented in assets/ Projects with grants Category Beginning balance Closing balance year or loss movement income Related to statement income Research on Common Co- construction Technology of Pharmaceutical Inhalation Preparations (开发区财政局 Financial Related to 2,800,000.00 2,000,000.00 0.00 0.00 4,800,000.00 Other income allocation assets 拔款创业领军人才项目: 药 品吸入制剂共性共建技术的 研究) Research and development of respiratory system drug and clinical research technology service platform project talent Financial Related to 1,500,000.00 50,000.00 0.00 0.00 1,550,000.00 Other income funding (呼吸系统药物研发 allocation assets 和临床研究技术服务平台项 目人才经费) Science and technology help the economy key special Financial Related to 500,000.00 0.00 0.00 0.00 500,000.00 Other income projects (科技助力经济重点 allocation assets 专项) City Service Development Financial Related to 800,000.00 0.00 0.00 0.00 800,000.00 Other income Special (市服务发展专项) allocation assets Financial Related to Patent funding (专利资助) 200,000.00 0.00 0.00 0.00 200,000.00 Other income allocation assets 2020 Shanghai Professional Technology Platform Capacity Enhancement Financial Related to Project (2020 年度上海市专 1,000,000.00 0.00 0.00 0.00 1,000,000.00 Other income allocation assets 业技术平台能力提升项目立 项) High-growth small and micro Financial Related to innovation enterprises (高成 400,000.00 0.00 0.00 0.00 400,000.00 Other income allocation assets 长小微科创企业) Technology giant (科技小巨 Financial Related to 0.00 1,200,000.00 0.00 0.00 1,200,000.00 Other income 人) allocation assets First application for corporate postdoctoral project research Financial Related to funding (首次申请企业博士 0.00 120,000.00 0.00 0.00 120,000.00 Other income allocation assets 后项目研究资助) Research and development subsidy for ω-3-Fish Oil Medium and Long Chain Fat Financial Related to Emulsion Injection (ω-3 鱼油 350,000.00 0.00 350,000.00 0.00 0.00 Other income allocation assets 中/长链脂肪乳注射液研究 开发补助) Atmospheric environmental quality improvement subsidy funds (Atmospheric Financial Related to environmental quality 0.00 161,504.00 3,588.98 0.00 157,915.02 Other income allocation assets improvement subsidy (大气 环境质量提升补贴)资金) R&D and industrialization of innovative Ilaprazole Series Financial Related to 16,078,166.25 0.00 4,910,000.04 0.00 11,168,166.21 Other income (艾普拉唑系列创新药物研 allocation assets 发及产业化) Research and development funds for new drug for Class I Treatment of Necrosis Factor in Human Tumour from Financial Related to 8,000,000.00 0.00 5,924,000.00 2,076,000.00 0.00 Other income Human Source (I 类治疗用人 allocation income 源化抗人肿瘤坏死因子 α 单 克隆抗体新药研制资金) Strategic emerging industries in 2014 (sustained release Financial Related to 16,700,000.00 0.00 0.00 0.00 16,700,000.00 Other income microspheres) (2014 年战略 allocation assets 性新兴产业 (缓释微球) ) Fund for industrialization of prolonged-action microsphere Financial Related to 12,550,000.00 0.00 0.00 0.00 12,550,000.00 Other income preparation (长效微球制剂的 allocation assets 产业化款项) Construction project for Financial Related to 20,719,505.48 0.00 2,405,309.88 0.00 18,314,195.60 Other income industrialization of allocation assets 252 Joincare Pharmaceutical Group Annual Report 2022 Item Related to Additions in the Transfer to profit Other presented in assets/ Projects with grants Category Beginning balance Closing balance year or loss movement income Related to statement income prolonged-action microsphere preparation (phase I) (长效微 球制剂产业化建设项目 (一 期工程) ) Project subsidy from the Ministry of Industry and Financial Related to 2,400,000.00 0.00 0.00 0.00 2,400,000.00 Other income Information Technology (工 allocation assets 业和信息化部项目补助款) Project subsidy from the Ministry of Industry and Financial Related to 1,366,750.00 0.00 231,000.00 0.00 1,135,750.00 Other income Information Technology (工 allocation assets 业和信息化部项目补助款) Construction of Drug Conformity Evaluation Research Center Platform (药 Financial Related to 1,040,000.14 0.00 159,999.96 0.00 880,000.18 Other income allocation assets 物一致性评价研究中心平台 建设) R&D and Commercialisation of Mouse Nerve Growth Factor for Injection (注射用 Financial Related to 40,045,946.93 0.00 10,560,089.28 0.00 29,485,857.65 Other income allocation assets 鼠神经生长因子研发及产业 化) Demonstration project on the application of solar photovoltaic architecture (太 Financial Related to 2,455,499.43 0.00 1,102,000.08 0.00 1,353,499.35 Other income allocation assets 阳能光电建筑应用示范项 目) Subsidy for the Tender of Technology Upgrade Project for PVC Soft Bag Supported by Provincial Finance Financial Related to 2,703,484.56 0.00 403,699.30 0.00 2,299,785.26 Other income Departments (省财政支持技 allocation assets 改招标项目补助金 PVC 软 袋) Technical transformation project of Shenqi Fuzheng Injection with flexible bag (软 Financial Related to 15,676,470.62 0.00 3,823,529.40 0.00 11,852,941.22 Other income allocation assets 袋(参芪扶正注射液) 技改项 目) Provision for technology transformation funds and Financial Related to 5,459,555.72 0.00 1,129,563.36 0.00 4,329,992.36 Other income subsequent grants (技术改造 allocation assets 资金拨款及事后补奖) Provision for technology transformation funds and Financial Related to 7,359,670.81 0.00 1,783,368.48 0.00 5,576,302.33 Other income subsequent grants (技术改造 allocation assets 资金拨款及事后补奖) Electricity distribution transformer performance enhancement for energy- saving and emission reduction Financial Related to projects (Energy-saving and 380,000.00 0.00 48,000.00 0.00 332,000.00 Other income allocation assets emission reduction projects (节能减排项目) ) 配电变压 器能效提升) R&D and industrialization team of chemical drug liquid Financial Related to 1,534,833.44 234,000.00 57,999.84 0.00 1,710,833.60 Other income preparation (化药液体制剂研 allocation assets 发与产业化团队) Innovation capacity building of technology center (antibody laboratory) (技术中 Financial Related to 4,802,478.80 0.00 514,338.20 0.00 4,288,140.60 Other income allocation assets 心创新能力建设 (抗体药物 实验室) ) Innovation capacity building of technology center (antibody laboratory) (技术中 Financial Related to 166,439.46 0.00 6,747.52 0.00 159,691.94 Other income allocation income 心创新能力建设 (抗体药物 实验室) ) 253 Joincare Pharmaceutical Group Annual Report 2022 Item Related to Additions in the Transfer to profit Other presented in assets/ Projects with grants Category Beginning balance Closing balance year or loss movement income Related to statement income Achievement transfer of blood screening (BCI) nucleic acid detection testing (血液筛 Financial Related to 3,961,282.44 0.00 631,622.73 0.00 3,329,659.71 Other income allocation assets 查 (BCI) 核酸检测试剂成 果转化) Technological upgrading and transformation projects of workshop for acarbose (APIs for α-glucosidase inhibitor) Financial Related to 464,285.80 0.00 107,142.84 0.00 357,142.96 Other income (α-葡萄糖苷酶抑制剂类原料 allocation assets 药阿卡波糖生产车间工艺升 级技术改造项目) R&D and industrialization of Financial Related to Statins (降血脂他汀类药物 30,000.48 0.00 30,000.48 0.00 0.00 Other income allocation assets 的研发与产业化) Scientific technology award and subsidy for technological Financial Related to 28,566.20 0.00 28,566.20 0.00 0.00 Other income innovative project (科学技术 allocation assets 奖及科技创新项目资助) Scientific technology award and subsidy for technological Financial Related to 2,200,000.00 0.00 0.00 0.00 2,200,000.00 Other income innovative project (科学技术 allocation income 奖及科技创新项目资助) Zhuhai industrial enterprise “cloud and platform” service coupons supporting funds (珠 Financial Related to 89,431.86 0.00 25,540.86 0.00 63,891.00 Other income allocation income 海市工业企业 “云上平台” 服务券支持资金) Commissioner workstation Financial Related to 85,000.00 0.00 60,000.00 0.00 25,000.00 Other income (特派员工作站) allocation assets Industrial revitalisation Financial Related to supporting funds (产业振兴 2,445,500.01 0.00 1,158,000.00 0.00 1,287,500.01 Other income allocation assets 扶持资金) Phase IV clinical study of innovative drug Ilaprazole (创 Financial Related to 8,210,800.00 0.00 8,210,800.00 0.00 0.00 Other income 新药物艾普拉唑 IV 期临床 allocation assets 研究) Government grant for Financial Related to industrial transformation (工 308,333.75 0.00 199,999.92 0.00 108,333.83 Other income allocation assets 业转型政府扶持资金) New industrialization Financial Related to development grant (新型工业 3,584,066.38 1,801,800.00 350,000.04 0.00 5,035,866.34 Other income allocation assets 化发展奖金) Policy fund for leading industrial enterprises loan Financial Related to 366,666.57 0.00 200,000.04 0.00 166,666.53 Other income Interests (工业龙头企业贷款 allocation assets 贴息政策资金) Supporting funds for five advantageous industrial clusters and one high-tech Financial Related to 300,000.20 0.00 99,999.96 0.00 200,000.24 Other income allocation assets industry (五优一新扶持资 金) Capital project for innovation and entrepreneurship team Financial Related to 12,500,000.00 0.00 750,000.00 0.00 11,750,000.00 Other income funding program (创新创业 allocation assets 团队资助计划资金项目) 2020 Zhuhai City Innovation and Entrepreneurship Team (Nanocrystalline) (2020 年度 Financial Related to 1,500,000.00 3,500,000.00 0.00 0.00 5,000,000.00 Other income allocation assets 珠海市创新创业团队 (纳米 晶) ) Fund for R&D and industrialization of innovative Ilaprazole series (艾普拉唑系 Financial Related to 5,600,000.00 0.00 5,600,000.00 0.00 0.00 Other income allocation assets 列创新药物研发及产业化) ) 项目资金) Key projects of industrial core and key technologies of Financial Related to 3,000,000.00 0.00 0.00 0.00 3,000,000.00 Other income allocation assets Zhuhai (Ryanodex) (珠海市 254 Joincare Pharmaceutical Group Annual Report 2022 Item Related to Additions in the Transfer to profit Other presented in assets/ Projects with grants Category Beginning balance Closing balance year or loss movement income Related to statement income 产业核心和关键技术攻关方 向项目 (丹曲林钠) ) Data-driven industrial chain collaboration platform demonstration project (数据 Financial Related to 3,650,000.00 0.00 730,000.00 0.00 2,920,000.00 Other income allocation assets 驱动的产业链协同平台示范 项目) Fund for key projects of industrial core and key technologies of Zhuhai (2nd Financial Related to batch) (珠海市产业核心和关 2,000,000.00 0.00 0.00 0.00 2,000,000.00 Other income allocation assets 键技术攻关方向项目资金 (第二批) ) Innovative drug of Ilaprazole Financial Related to sodium for injection (创新药 2,400,000.00 0.00 120,000.00 0.00 2,280,000.00 Other income allocation assets 注射用艾普拉唑钠针剂) Technological transformation projects of new Cefuroxime Financial Related to 1,533,100.00 0.00 0.00 0.00 1,533,100.00 Other income (新型头孢粉针剂技术改造 allocation assets 项目) Advanced Pharmaceutical Manufacturing Internet Financial Related to 675,000.00 0.00 90,000.00 0.00 585,000.00 Other income Benchmarking Project (先进 allocation assets 药品制造互联网标杆项目) Cleaner Production Audit Financial Related to 180,000.08 0.00 9,999.96 0.00 170,000.12 Other income Project (清洁生产审核项目) allocation assets Financial Related to Green factory (绿色工厂) 1,131,666.71 0.00 129,999.96 0.00 1,001,666.75 Other income allocation assets HCG PROJECT CONSTRUCTION (HCG 项 Financial Related to 3,387,835.84 0.00 395,649.96 0.00 2,992,185.88 Other income allocation assets 目建设) Sewage treatment system upgrade project (污水处理系 Financial Related to 64,239.92 0.00 8,030.04 0.00 56,209.88 Other income allocation assets 统升级改造项目) R&D and industrialization of Recombinant Human Chorionic Gonadotropin for Financial Related to 1,137,500.00 0.00 150,000.00 0.00 987,500.00 Other income Injection (注射用重组人绒促 allocation assets 性素研发及产业化) Development and Industrialization of Cyclosporin Self-emulsifying Soft Capsules with High Financial Related to 0.00 800,000.00 14,000.00 0.00 786,000.00 Other income Technology Barriers (高技术 allocation assets 屛障的环孢素自乳化软胶囊 制剂的开发及产业化研究) Guangdong Provincial Key Laboratory of Characteristic Drug R&D Enterprises (广东 Financial Related to 0.00 1,000,000.00 58,333.31 0.00 941,666.69 Other income allocation assets 省特色药物研发企业重点实 验室) Subsidies for online monitoring equipment and installations of coalfired Financial Related to 82,500.00 0.00 22,500.00 0.00 60,000.00 Other income allocation assets boilers (燃煤锅炉在线监控 设备装置补助) ) 资金) Funds for joint R&D and industrialization of integrated platform for molecular Financial Related to diagnostics (集成一体化分子 181,632.12 0.00 127,715.81 0.00 53,916.31 Other income allocation assets 诊断平台的合作研发及产业 化) ) 资金) Project supporting fund for the first batch of special funds for scientific and technological innovation in Financial Related to 600,000.00 0.00 0.00 0.00 600,000.00 Other income 2019 (2019 年度第一批科技 allocation assets 创新专项资金立项配套资 助) 255 Joincare Pharmaceutical Group Annual Report 2022 Item Related to Additions in the Transfer to profit Other presented in assets/ Projects with grants Category Beginning balance Closing balance year or loss movement income Related to statement income Provincial industrial innovation (provincial enterprise technology center) Financial Related to project in 2019 (2019 年度省 1,046,533.33 0.00 967,303.60 0.00 79,229.73 Other income allocation assets 产业创新 (省级企业技术中 心) 项目) China Postdoctoral Science Foundation subsidy funds (中 Financial Related to 80,000.00 0.00 6,283.19 73,716.81 0.00 Other income 国博士后科学基金会资助经 allocation income 费) Pre-appropriation of special grants for industrialization of diagnostic reagents for Financial Related to COVID-19 (新型冠状病毒检 4,116,415.65 0.00 26,694.08 0.00 4,089,721.57 Other income allocation assets 测试剂产业化项目补助金预 拨) Xiangzhou District equipment purchase subsidy supporting funds (Special funds for epidemic prevention and Financial Related to 11,467.25 0.00 2,317.04 0.00 9,150.21 Other income control) (香洲区采购设备补 allocation assets 贴扶持资金 (疫情防控专项 资金) Zhuhai innovation and enterprising team and high- level talent enterprising Financial Related to project Phase I funds (珠海市 12,000,000.00 0.00 0.00 0.00 12,000,000.00 Other income allocation assets 创新创业团队和高层次人才 创业项目首期资金) Overall relocation and deployment expansion project Financial Related to 20,000,000.00 30,000,000.00 0.00 0.00 50,000,000.00 Other income allocation assets (整体搬迁调迁扩建项目) Environmental protection bureau RTO project special Financial Related to 179,999.96 0.00 20,000.04 0.00 159,999.92 Other income funds (环保局 RTO 项目资 allocation assets 金) Structure-efficiency optimization of marine microorganisms and Financial Related to evaluation of antitumor 312,366.27 0.00 213,157.10 0.00 99,209.17 Other income allocation income activity (海洋微生物构效优 化与抗肿瘤活性评价) R&D and demonstration of key technologies for the development and utilization of swim bladder (golden oyster) marine traditional Financial Related to 0.00 750,000.00 0.00 0.00 750,000.00 Other income Chinese medicine resources allocation income (鱼鳔(黄金鮸) 海洋中药资 源开发与利用关键技术研发 与示范) 2022 Special funds for the reconstruction of the industrial base and the high- quality development of the manufacturing industry from Financial Related to 0.00 32,740,000.00 4,774,583.31 0.00 27,965,416.69 Other income the central finance (2022 年 allocation assets 中央财政产业基础再造和制 造业高质量发展专项资金) 示范) National Science and Technology Major Special Project Subsidy Fund Financial Related to 0.00 4,744,900.00 2,362,093.09 0.00 2,382,806.91 Other income LZM009 (国家科技重大专 allocation assets 项项目后补助资金 LZM009) Xiangzhou District actively responds to the impact of the Financial Related to epidemic and maintains 0.00 1,644,800.00 0.00 0.00 1,644,800.00 Other income allocation income stability, innovation drives technology industry project 256 Joincare Pharmaceutical Group Annual Report 2022 Item Related to Additions in the Transfer to profit Other presented in assets/ Projects with grants Category Beginning balance Closing balance year or loss movement income Related to statement income (香洲区积极应对和疫情影 响保稳创新驱动科技工业分 项) Total 433,543,352.40 91,591,736.00 138,448,104.04 2,149,716.81 384,537,267.55 (2) Government grants recognized in income for the year by gross method Amount Amount recognised Presented in Related to recognised in Projects with grants Category in profit or loss in income assets/ Related profit or loss in prior year statement to income the year Financial Related to Social security subsidy (社保补助) 72,684.89 226,308.66 Other income allocation income Financial Related to Patent grant (专利补助) 300,000.00 2,500.00 Other income allocation income Financial Related to Job stabilization subsidy (稳岗补贴) 122,853.35 1,075,941.53 Other income allocation income Financial Related to Electricity subsidy (用电补助) 1,245,193.22 570,533.30 Other income allocation income Financial Related to Maternity benefits (生育津贴) 298,510.00 404,108.83 Other income allocation income Financial Related to Export credit insurance subsidy (出口信保补贴) 364,900.00 1,126,400.00 Other income allocation income New inhalation drug formulation creation project (新型 Financial 0.00 53,637,825.12 Other income Related to assets 吸入给药制剂创制项目) allocation Budesonide project acceptance transferred to other Financial 1,991,666.67 350,000.04 Other income Related to assets income (布地奈德项目验收转其他收益) allocation Financial Related to Enterprise R&D investment plan (企业研发投入计划) 2,000,000.00 0.00 Other income allocation income Financial Related to Job training subsidy (适岗培训补贴 ) 236,835.00 0.00 Other income allocation income Construction of an integrated production line for fully automatic blister-type dry powder inhalant micro-filling Financial 1,492,333.34 0.00 Other income Related to assets and winding (全自动泡罩型干粉吸入剂微量灌封与卷 allocation 绕一体化生产线建设) Study on the technology of antifungal drug caspofungin Financial 1,500,000.00 0.00 Other income Related to assets (抗真菌药卡泊芬净工艺研究) allocation Laboratory project of respiratory system inhalation preparation engineering laboratory project (呼吸系统吸 Financial 1,346,750.00 0.00 Other income Related to assets allocation 入制剂工程实验室项目) Laboratory project of respiratory system inhalation preparation engineering laboratory project (呼吸系统吸 Financial 0.00 1,616,100.00 Other income Related to assets allocation 入制剂工程实验室项目) The 9th batch of job training subsidies for enterprises in Financial Related to Yantian District in 2020 (2020 年盐田区企业适岗培训 2,880,000.00 0.00 Other income allocation income 补贴第 9 批次) The first batch of funding support for the development of Financial Related to science and technology industries in 2021 (2021 年第一 3,000,000.00 0.00 Other income allocation income 批科技类产业发展资金扶持资助) 2015 Pilot Project of United Development of Emerging Strategic Industrial Regions in Guangdong Province Financial 9,500,002.00 0.00 Other income Related to assets (2015 年广东省战略性新兴产业区域集聚发展试点项 allocation 目) Funds allocated by the Ministry of Finance (财政局拨付 Financial 1,219,192.66 1,219,192.68 Other income Related to assets 补助资金) allocation Special funds for corporate R&D financial subsidies in Financial Related to 720,000.00 0.00 Other income 2020 (2020 年企业研发财政补助专项资金) allocation income The third batch of biopharmaceutical industry leader (第 Financial Related to 500,000.00 0.00 Other income 三批次生物医药产业领航) allocation income Compensation for temporary land occupation at Financial Related to Songping Station of Metro Line 13 (地铁 13 号线松坪 0.00 361,614.00 Other income allocation income 站临时占地补偿款) Financial Related to Quarterly property tax relief (减免一个季度房产税) 0.00 583,508.46 Other income allocation income Amortization of Deferred Earnings*Marine Projects (摊 Financial 0.00 19,562,000.00 Other income Related to assets 销递延收益*海洋项目) allocation Quality brand double promotion support plan (质量品牌 Financial Related to 400,000.00 0.00 Other income 双提升扶持计划) allocation income 257 Joincare Pharmaceutical Group Annual Report 2022 The first batch of funding for the 2020 Enterprise Financial Related to Research and Development Funding Program (2020 年企 871,000.00 0.00 Other income allocation income 业研究开发资助计划第一批资助) Deferred income 摊销*国家重大专项项目注射脂质研 Financial 0.00 500,000.00 Other income Related to assets 究经费(已验收) allocation Industrial value-added growth rate projects (工业增加值 Financial Related to 0.00 1,145,100.00 Other income 增速达标项目) allocation income 2021 Annual Industrial Added Value Growth Standard Financial Related to 0.00 946,624.88 Other income Award (2021 年度工业增加值增速达标奖励) allocation income 2022 Industrial Enterprise Expansion and Efficiency Support Program Funding (2022 年工业企业扩产增效 Financial Related to 0.00 1,650,000.00 Other income allocation income 扶持计划资助) 2022 High-tech Enterprise Cultivation Funding First Batch of Grants Shenzhen Science and Technology Financial Related to 0.00 500,000.00 Other income Innovation No. 202225 (2022 年高新技术企业培育资 allocation income 助第一批拨款深科技创新 202225 号) 2022 Industrial "Carbon Peak" Pilot Demonstration Financial Related to Project Funding Fund (2022 年工业“碳达峰”工作试点 0.00 500,000.00 Other income allocation income 示范项目资助款) Freeze-dried raw material production line project funding Financial Related to 0.00 2,045,300.00 Other income (冻干原料生产线项目资助经费) allocation income Funds for Encouraging Industrial Enterprises to Expand Financial Related to Production and Increase Efficiency (鼓励工业企业扩产 0.00 620,000.00 Other income allocation income 增效项目经费) Preclinical study of targeted anti-tumor innovative drug Financial Related to 500,000.00 0.00 Other income JK00265 (靶向抗肿瘤创新药物 JK00265 临床前研究) allocation income Science and Technology Development Fund for Financial Related to Enterprise R&D Institutions in Pudong New District (浦 800,000.00 0.00 Other income allocation income 东新区科技发展基金企业研发机构专项) Special subsidy for research and development expenses Financial Related to 550,000.00 100,000.00 Other income of gazelle enterprises (瞪羚企业研发费专项补助) allocation income 2022 The central government guides local science and technology development funds (2022 年中央引导地方 Financial Related to 0.00 400,000.00 Other income allocation income 科技发展资金 40 万) Funds to support business development (扶持企业发展 Financial Related to 0.00 3,543,000.00 Other income 资金) allocation income Grant Funding for Science and Technology Projects (科 Financial Related to 0.00 1,500,000.00 Other income 技项目补助资金) allocation income Financial Related to Government grants 0.00 1,400,000.00 Other income allocation income 2022 High-tech Cultivation Fund (22 年高新培育资助 Financial Related to 0.00 500,000.00 Other income 款) allocation income 2022 Shenzhen High-tech Zone Special Fund Municipal Financial Related to 0.00 750,000.00 Other income Funding (2022 年度深圳高新区专项资金市级资助款) allocation income In the first half of 2022, subsidies for industrial assistance projects to help enterprises bail out (2022 年上 Financial Related to 0.00 383,300.00 Other income allocation income 半年工业助企纾困项目补助) High-tech Zone Finance Bureau’s 2021 special funds for enterprise R&D financial subsidies (高新区财政局 2021 Financial Related to 0.00 320,000.00 Other income allocation income 年企业研发财政补助专项资金) ) High-tech Zone Finance Bureau 2022 Central Air Financial Related to Pollution Prevention and Control Fund (高新区财政局 0.00 750,000.00 Other income allocation income 2022 年中央大气污染防治资金) The second batch of funding plans for technological Financial Related to transformation investment projects in 2021 (2021 年技术 1,710,000.00 0.00 Other income allocation income 改造投资项目第二批资助计划) 2022 Shenzhen High-tech Zone Development Special Plan Science and Technology Enterprise Cultivation Financial Related to 0.00 500,000.00 Other income Project Subsidy (2022 年度深圳高新区发展专项计划 allocation income 科技企业培育项目补助-深圳市坪山区科技创新局) Financial Related to One-time job training subsidy (一次性留工培训补助) 0.00 311,875.00 Other income allocation income Government Subsidy of Special Fund for Scientific and Technological Innovation-Shenzhen Pingshan District Financial Related to 1,085,794.00 0.00 Other income Science and Technology Innovation Bureau (科技创新 allocation income 专项资金政府补助-深圳市坪山区科技创新局) Financial Related to Export credit insurance subsidy (出口信保补贴) 1,991,489.70 2,087,098.80 Other income allocation income Financial Related to R&D subsidy (研究开发费补助)) 6,267,222.00 1,200,440.00 Other income allocation income Research and development funds for new drug for Class I Financial Related to 0.00 5,924,000.00 Other income Treatment of Necrosis Factor in Human Tumour from allocation income 258 Joincare Pharmaceutical Group Annual Report 2022 Human Source (I 类治疗用人源化抗人肿瘤坏死因子 α 单克隆抗体新药的研制资金) Government Subsidy for Long-acting Microspheres Financial Major New Drug Creation (长效微球重大新药创制政 4,784,320.37 3,155,309.88 Other income Related to assets allocation 府补助) R&D and industrialization of innovative Ilaprazole Series Financial 4,910,000.04 18,720,800.04 Other income Related to assets (艾普拉唑系列创新药物研发及产业化) allocation R&D and industrialization of innovative Ilaprazole Series Financial Related to 560,000.00 0.00 Other income (艾普拉唑系列创新药物研发及产业化) allocation income Financial HCG PROJECT CONSTRUCTION (HCG 项目建设) 395,649.97 395,649.96 Other income Related to assets allocation Fiscal Subsidy and Operating Subsidy (财政补贴及经营 Financial Related to 119,047,484.00 59,063,950.86 Other income 运营补贴) allocation income R&D and Commercialisation of Mouse Nerve Growth Factor for Injection (注射用鼠神经生长因子研发及产 Financial 10,560,089.27 10,560,089.28 Other income Related to assets allocation 业化) Provincial Science and Technology Innovation Strategy Financial 473,166.56 57,999.84 Other income Related to assets Special Fund (省科技创新战略专项资金) allocation Import discount and supporting funds (进口贴息及配套 Financial Related to 0.00 500,000.00 Other income 资金) allocation income Promoting Imports of Foreign Trade Development Financial Related to 50,352.00 1,809,479.00 Other income Special Fund (外贸经济发展专项资金) allocation income Subsidy for the Tender of Technology Upgrade Project for PVC Soft Bag Supported by Provincial Finance Financial 408,365.76 403,699.30 Other income Related to assets Departments (省财政支持技改招标项目补助金 PVC allocation 软袋) Technical transformation project of Shenqi Fuzheng Financial Injection with flexible bag (软袋(参芪扶正注射液) 技 3,823,529.40 3,823,529.40 Other income Related to assets allocation 改项目) Demonstration project on the application of solar Financial photovoltaic architecture (太阳能光电建筑应用示范项 1,102,000.08 1,102,000.08 Other income Related to assets allocation 目) Financial Related to Electricity Incentive Funds (用电奖励资金) 364,257.43 20,000.00 Other income allocation income Subsidies for high and new technology enterprises and high and new technology products (高新技术企业及高 Financial Related to 1,071,346.00 250,000.00 Other income allocation income 新技术产品项目补贴) Grants to high-growth technology companies from Dazhangjiang project A04 (大张江项目 A04 对高增长 Financial Related to 1,500,000.00 1,500,000.00 Other income allocation income 技术企业资助款) Provision for technology transformation funds and Financial Related to 1,576,000.00 2,300,000.00 Other income subsequent grants (技术改造资金拨款及事后补奖) allocation income Provision for technology transformation funds and Financial 4,131,600.00 2,543,679.56 Other income Related to assets subsequent grants (技术改造资金拨款及事后补奖) allocation Technology transformation of recycling system of Financial 397,818.48 397,818.48 Other income Related to assets Acarbose project (阿卡波糖糖回收系统技术改造项目) allocation Special Fund and Encouraging funds for Energy Saving Financial Related to 352,000.00 289,500.00 Other income and Emission Reduction (节能减排专项资金及奖励金) allocation income Scientific technology award and subsidy for Financial Related to technological innovative project (科学技术奖及科技创 7,352,000.00 2,663,400.00 Other income allocation income 新项目资助) Patent (Intellectual Property) Support Fund (专利(知识 Financial Related to 849,370.00 548,500.00 Other income 产权)资助资金) allocation income Reward Fund for Industry Growth and Production Financial Related to 5,050,000.00 667,700.00 Other income Expansion (工业保值增长及增产奖励) allocation income New industrialization development funds (新型工业化 Financial 350,000.04 350,000.04 Other income Related to assets 发展资金) allocation Industrial revitalisation supporting funds (产业振兴扶持 Financial 1,158,000.00 1,158,000.00 Other income Related to assets 资金) allocation Financial Related to Industrial supporting funds (产业扶持资金) 13,000.00 944,100.00 Other income allocation income Employment Assurance and Re-employment and Attraction to Graduates of Tertiary Academic Institutions Financial Related to 5,024,018.69 5,949,048.90 Other income Subsidy (企业稳岗及再就业和吸纳高校毕业生补贴 allocation income 款) New Scientific Research Institution Subsidy (新型科研 Financial 2,000,000.00 0.00 Other income Related to assets 机构补助资金) allocation Enterprise Technology Center Innovation Capacity Financial Development (Antibody Laboratory) (企业技术中心创 445,755.36 514,338.20 Other income Related to assets allocation 新能力建设 (抗体药物试验室) ) 259 Joincare Pharmaceutical Group Annual Report 2022 Supporting subsidy for “Talents Plan” and subsidy for Financial Related to talents introduction and cultivation ( “人才计划”配套补 646,759.03 583,774.23 Other income allocation income 贴及引才育才补贴) Integrating Informatization and Industrialization Rewards Financial Related to 0.00 500,000.00 Other income (两化融合奖励) allocation income Incentive funds for expansion of export scale (扩大出口 Financial Related to 519,700.00 456,300.00 Other income 规模奖励基金) allocation income Special funds for key leading enterprises in the 13th Financial Related to Five-Year Plan (2019) (十三五重点领军企业专项资金 0.00 14,133,300.00 Other income allocation income (2019 年) Financial Related to Subsidies for work-based training (以工代训补贴) 848,400.00 395,000.00 Other income allocation income Financial Related to Subsidies for insurance fees (保险费用补贴) 200,000.00 609,243.30 Other income allocation income Special Funds for Promoting High-quality Economic Financial 357,200.00 5,741,886.91 Other income Related to assets Development (促进经济高质量发展专项资金) allocation Special Funds for Promoting High-quality Economic Financial Related to 3,540,020.00 11,578,756.00 Other income Development (促进经济高质量发展专项资金) allocation income Funds for joint R&D and industrialization of integrated platform for molecular diagnostics (集成一体化分子诊 Financial 1,368,367.87 127,715.81 Other income Related to assets allocation 断平台的合作研发及产业化) Funds for industrial volatile organic pollution control Financial Related to 628,000.00 0.00 Other income projects (工业挥发性有机污染治理项目资金) allocation income Achievement transfer of blood screening BCI nucleic Financial acid detection testing (血液筛查 BCI 核酸检测试剂成 2,038,717.57 631,622.73 Other income Related to assets allocation 果转化) COVID-19 emergency technology special emergency Financial fund and special grants for industrialization (新冠应急科 1,084,784.35 26,694.08 Other income Related to assets allocation 技攻关专项款及产业化项目补助金) Financial Related to “Specialized and new” subsidy ( “专精特新”补贴) 175,000.00 1,200,000.00 Other income allocation income Hengqin Guangdong-Macao Deep Cooperation Zone Financial Related to Factory Rental Subsidy (横琴粤澳深度合作区厂房租金 0.00 690,024.00 Other income allocation income 补贴) Zhuhai Investment Promotion Award (珠海市招商引资 Financial Related to 0.00 600,000.00 Other income 奖) allocation income National Science and Technology Major Special Project Financial Subsidy Fund LZM009 (国家科技重大专项项目后补助 0.00 2,362,093.09 Other income Related to assets allocation 资金 LZM009) Data-driven industrial chain collaboration platform demonstration project (数据驱动的产业链协同平台示 Financial 0.00 730,000.00 Other income Related to assets allocation 范项目) Several Measures for Payment Enterprises to Overcome Difficulties in Response to the Novel Coronavirus Pneumonia Epidemic-Financial Support Project Funds Financial Related to 6,093,000.00 381,000.00 Other income allocation income (应对新型冠状病毒肺炎疫情支付企业共渡难关的若 干措施-金融支持项目资金) Project funds for promoting the development of the biomedical industry (促进生物医药产业发展用途项目 Financial Related to 0.00 7,665,180.00 Other income allocation income 资金) Application of artificial intelligence in triptorelin long- Financial Related to acting microsphere preparation (人工智能在曲普瑞林长 0.00 800,000.00 Other income allocation income 效微球制剂中的应用) Financial Others 2,271,603.34 2,584,330.85 Other income Related to assets allocation Financial Related to Others 4,847,038.25 7,044,647.21 Other income allocation income Financial Total 245,335,140.69 286,842,932.33 allocation (3) Government grants using the net amount method to offset related costs None. (4) Return of government grants Item Amount Reason Research and development funds for new drug for Class I Treatment of Necrosis Factor in Human Tumour from Return the remaining funds 2,076,000.00 Human Source (I 类治疗用人源化抗人肿瘤坏死因子 α 单 after the project is completed 克隆抗体新药研制资金) 260 Joincare Pharmaceutical Group Annual Report 2022 China Postdoctoral Science Foundation subsidy funds (中国 73,716.81 Balance returned 博士后科学基金会资助经费) VI. Changes in the scope of consolidation 1. Disposal of subsidiaries None. 2. Set-up of subsidiaries The Company’s subsidiary, Jiaozuo Joincare Bio Technological Co., Ltd. (焦作健康元生物制品有限公司) together with Fenghuolun (Shanghai) Biotechnology Co., Ltd. (风火轮(上海) 生物科技有限公司) to established Jiaozuo Jianfeng Biotechnology Co., Ltd. on 5 August 2022, with a registered capital of RMB50 million. Jiaozuo Joincare Bio Technological Co., Ltd. (焦作健康元生物制品有限公司) is holding 66.5% shares. 3. Change to scope of consolidation in the subsidiary Livzon Group The Company's subsidiary, Livzon Group's Subsidiaries Livzon Biotechnology Hong Kong Co., Ltd. established LIVZON BIOLOGICS (MALAYSIA) SDN. BHD. on January 12, 2022, with registered capital of Malaysia Ringgit 100, of which the Livzon Group's investment is Malaysia Ringgit 100 and accounts for its registered capital of 100%. VII. Equity in other entities 1. Interests in subsidiaries (1) Group structure Main Shareholding % Type of Corporate Place of Business Acquisition Name of subsidiary operating Registered capital subsidiaries Category registration nature Indire method location Direct ct Topsino Industries Limited Wholly- Limited Set-up by (天诚实业有限公司) owned Hong Kong Hong Kong Business HKD896,933,973.00 100 company investment (Topsino) ) subsidiary Shenzhen Taitai Genomics Wholly- Inc. Co., Ltd. (深圳太太基 Limited Set-up by owned Shenzhen Shenzhen Industry RMB50,000,000.00 75 25 因工程有限公司)(Taitai subsidiary company investment Genomics) ) Shenzhen Taitai Pharmaceutical Industry Wholly- Limited Set-up by Co., Ltd. (深圳太太药业 owned Shenzhen Shenzhen Industry RMB100,000,000.00 100 company investment 有限公司) (Taitai subsidiary Pharmaceutical) Health Investment Wholly- Limited The British The British Set-up by Holdings Ltd. (Health owned Investment USD50,000.00 100 company Virgin Islands Virgin Islands investment Investment) subsidiary Joincare Pharmaceutical Wholly- Limited The British The British Set-up by Group Industry owned Investment USD 50,000.00 100 company Virgin Islands Virgin Islands investment Co.,Ltd.(BVI) * subsidiary Joincare Pharmaceutical Wholly- Group Industry Limited Cayman Cayman Set-up by owned Investment USD 50,000.00 100 Co.,Ltd.(CAYMAN company Islands Islands investment subsidiary ISLANDS) Xinxiang Haibin Wholly- Limited Henan Henan Set-up by Pharmaceutical Co., owned Industry RMB170,000,000.00 100 company Xinxiang Xinxiang investment Ltd.(Xinxiang Haibin) (新 subsidiary 261 Joincare Pharmaceutical Group Annual Report 2022 Main Shareholding % Type of Corporate Place of Business Acquisition Name of subsidiary operating Registered capital subsidiaries Category registration nature Indire method location Direct ct 乡海滨药业有限公司(新 乡海滨) ) Shenzhen Fenglei Electric Power Investment Co., Wholly- Limited Set-up by Ltd. (深圳市风雷电力投 owned Shenzhen Shenzhen Investment RMB100,000,000.00 100 company investment 资有限公司) (Fenglei subsidiary Electric Power) ) Jiaozuo Joincare Bio Technological Co., Ltd. Wholly- Limited Set-up by (焦作健康元生物制品有 owned Henan Jiaozuo Henan Jiaozuo Industry RMB500,000,000.00 75 25 company investment 限公司) (Jiaozuo subsidiary Joincare) ) Shanghai Frontier Health Pharmaceutical Technology Co., Ltd. (上 Limited Set-up by Subsidiaries Shanghai Shanghai Industry RMB50,000,000.00 65 海方予健康医药科技有 company investment 限公司)(Shanghai Frontier) Shenzhen Taitai Biological Wholly- Technology Co., Ltd (深圳 Limited Set-up by owned Shenzhen Shenzhen Industry RMB5,000,000.00 100 太太生物科技有限公司) subsidiary company investment (Taitai Biological) Guangzhou Joincare Respiratory Medicine Engineering Technology Limited Set-up by Co., Ltd. (广州健康元呼 Subsidiaries Guangzhou Guangzhou Industry RMB10,000,000.00 26 company investment 吸药物工程技术有限公 司) (Joincare Respiratory ) Guangdong Taitai Forenstic Test Institute (广 Wholly- Other Set-up by owned Shenzhen Shenzhen Business RMB0.00 100 东太太法医物证司法鉴 organization investment subsidiary 定所(鉴定所) ) Joincare Haibin Pharmaceutical Co., Ltd. Wholly- Limited Set-up by owned Shenzhen Shenzhen Industry RMB500,000,000.00 25 75 (健康元海滨药业有限公 company investment subsidiary 司) (Joincare Haibin) ) Shenzhen Haibin Business Pharmaceutical Co., Ltd. Wholly- combination Limited owned Shenzhen Shenzhen Industry RMB700,000,000.00 97.87 2.13 not under (深圳市海滨制药有限公 company subsidiary common 司) (Haibin Pharma) control Joincare Daily-Use & Business Health Care Co., Ltd. (健 Wholly- combination Limited owned Shenzhen Shenzhen Business RMB25,000,000.00 80 20 not under 康元日用保健品有限公 company subsidiary common 司) (Joincare Daily-Use) control Health Pharmaceuticals Business Wholly- combination (China) Limited (健康药 Limited owned Zhuhai Zhuhai Industry HKD73,170,000.00 100 not under 业(中国) 有限公司) subsidiary company common (Health China) control Livzon Pharmaceutical Business combination Group Inc. (丽珠医药集团 Joint-stock Subsidiaries Zhuhai Zhuhai Industry RMB935,552,687.00 23.66 21.11 not under 股份有限公司) (Livzon company common Group) * Note 1 & 2 control Hong Kong Health Business Pharmaceutical Industry Wholly- combination Limited owned Hong Kong Hong Kong Investment HKD10,000.00 100 not under Company Limited (香港健 company subsidiary common 康药业有限公司) control 262 Joincare Pharmaceutical Group Annual Report 2022 Main Shareholding % Type of Corporate Place of Business Acquisition Name of subsidiary operating Registered capital subsidiaries Category registration nature Indire method location Direct ct Business Health Pharmaceutical Wholly- combination Limited Industry Company Limited owned Hong Kong Hong Kong Investment HKD10,000.00 100 not under company (健康药业有限公司) subsidiary common control Shenzhen Hiyeah Industry Business Wholly- combination Co., Ltd (深圳市喜悦实业 Limited owned Shenzhen Shenzhen Business RMB178,000,000.00 97.58 2.42 not under 有限公司) (Shenzhen subsidiary company common Hiyeah) ) control Business Guangzhou Hiyeah Wholly- combination Limited Industry Co., Ltd. (广州市 owned Guangzhou Guangzhou Industry RMB3,000,000.00 100 not under company 喜悦实业有限公司) subsidiary common control Business Zhongshan Renhe Health Wholly- combination Limited Products Co., Ltd. (中山市 owned Zhongshan Zhongshan Industry RMB500,000.00 100 not under company 仁和保健品有限公司) subsidiary common control Business Shenzhen Jiekang Health Wholly- combination Limited Care Co., Ltd. (深圳市捷 owned Shenzhen Shenzhen Industry RMB4,000,000.00 100 not under company 康保健有限公司 ) subsidiary common control Joincare (Guangdong) Special medicine Food Wholly- Limited Set-up by Co., Ltd. (健康元(广东) owned Shaoguan Shaoguan Industry RMB20,000,000.00 100 company investment 特医食品有限公司) subsidiary (Joincare Special Food) Henan Joincare Biology Limited Set-up by Medical Research Institute Subsidiaries Jiaozuo Jiaozuo Industry RMB100,000,000.0 70.13 company investment Co., Ltd.* Note 3 Jiaozuo Jianfeng Limited Set-up by Biotechnology Co., Ltd. Subsidiaries Jiaozuo Jiaozuo Industry RMB50,000,000.0 66.5 company investment *Note 4 *Note 1: Shanghai Frontier Health Pharmaceutical Technology Co., Ltd. (上海方予健康医药科技有限公司) and the Company's subsidiary Livzon Group established Shanghai Liyu Biomedical Technology Co., Ltd. (上海丽予生物医药技术有限责任公司) on 30 March 2021. Livzon Group holds 55% of the shares and Shanghai Frontier Health Pharmaceutical Technology Co., Ltd holds 45%. *Note 2: Zhuhai Livzon Biotechnology Co., Ltd. (珠海市丽珠生物医药科技有限公司) is a subsidiary within the scope of Livzon Group's consolidation. It was originally 100% indirectly held by Livzon Group. In the current period, due to the restructuring of the shareholding structure of the subsidiary, Livzon Group holds 51% of its shares, the Company holds 33.07% of the shares, YF Pharmab Limited holds 8.43% of the shares, and Hainan Lishengjuyuan Investment Partnership (Limited Partnership) (海南丽生聚源投资合伙企业(有限合伙)) holds 7.50%. *Note 3: Henan Joincare Biomedical Research Institute Co., Ltd. (河南省健康元生物医药研究院有限公司) is a joint venture established on 26 October 2020 by Jiaozuo Joincare Biological Products Co., Ltd. (焦作健康元生物制品有限公司), a subsidiary of the Company, and Livzon Group Xinbeijiang Pharmaceutical Co., Ltd. (丽珠集团新北江制药股份有限公司), a subsidiary of the Company’s Livzon Group. Jiaozuo Joincare Biological Products Co., Ltd. holds 51% of the shares. The investee completed its industrial and commercial registration on 26 October 2020. *Note 4: Jiaozuo Jianfeng Biotechnology Co., Ltd. Is jointed established by the Company’s subsidiary, Jiaozuo Joincare Bio Technological Co., Ltd. (焦 作健康元生物制品有限公司) and Fenghuolun (Shanghai) Biotechnology Co., Ltd. (风火轮(上海) 生物科技有限公司) on 5 August 2022. Jiaozuo Joincare Bio Technological Co., Ltd. (焦作健康元生物制品有限公司) holds 66.5% shares. Subsidiaries not included in the scope of consolidation in the current period: Name of subsidiary Registered capital Actual investment Interest held Guangzhou Hiyeah Industry Co., Ltd. (广州 3,000,000.00 3,000,000.00 100% 市喜悦实业有限公司) Zhongshan Renhe Health Products Co., Ltd. 500,000.00 500,000.00 100% 263 Joincare Pharmaceutical Group Annual Report 2022 (中山市仁和保健品有限公司) Shenzhen Jiekang Health Care Co., Ltd. (深 4,000,000.00 4,000,000.00 100% 圳市捷康保健有限公司 ) Guangzhou Hiyeah Industry Co., Ltd. (广州市喜悦实业有限公司), Zhongshan Renhe Health Products Co., Ltd. (中山市仁和保健品有限公司) are wholly-owned subsidiaries of Shenzhen Hiyeah. They entered the liquidation process in 2008, and has been out of business for many years, and completed the tax cancellation procedures, so they were not included in the scope of the consolidated. Shenzhen Jiekang Health Care Co., Ltd. (深圳市捷康保健有限公司) was wholly-owned subsidiary of Shenzhen Hiyeah. It had entered the liquidation process in 2008, and has been out of business for many years, and completed the tax cancellation procedures, and it was approved and cancelled by Shenzhen Market Supervision and Administration Bureau on May 30, 2022. (2) Significant non-wholly owned subsidiaries Profit or loss Balance of minority Name of Shareholding of Dividend paid to attributable to minority interests at period subsidiary minority interest minority interest interest end Livzon Group 55.2266% 1,053,970,833.13 670,811,289.90 7,663,254,428.90 (3) Principal financial information of significant non-wholly owned subsidiaries Closing balance Name of subsidiary Non-current Non-current Current assets Total assets Current liabilities Total liabilities assets liabilities Livzon 16,987,297,040.38 7,877,528,325.85 24,864,825,366.23 7,396,664,920.29 2,531,908,854.22 9,928,573,774.51 Group Continued (1) : Beginning balance Name of subsidiary Non-current Non-current Current assets Total assets Current liabilities Total liabilities assets liabilities Livzon 14,673,096,594.67 7,698,818,996.15 22,371,915,590.82 6,925,068,067.24 1,135,822,729.96 8,060,890,797.20 Group Continued (2) : Current year Prior year Name of subsidia Total Cash flows from Total ry Cash flows from Operating income Net profit comprehensive operating Operating income Net profit comprehensive operating activities income activities income Livzon 12,629,579,047.66 1,955,540,213.06 2,084,847,720.65 2,772,671,295.03 12,063,863,272.98 1,952,101,168.93 1,834,898,051.39 1,902,328,139.03 Group (4) Changes in share of owners' equity in subsidiaries and still controls the subsidiaries None. 264 Joincare Pharmaceutical Group Annual Report 2022 2. Interests in joint arrangement or associates (1) Significant associates Joint venture or associate Main Shareholding (%) Accounting Place of Business Name of other related operating treatment of registration nature Direct Indirect parties location investment Associates Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. Henan Henan For electricity Jiaozuo 0.00 49 Equity method (焦作金冠嘉华电力有限 Jiaozuo City production City 公司) Tianjin Tongrentang Pharmaceutical Group Co., Ltd. (天津同 Tianjin Tianjin 0.00 40 Equity method manufacturing 仁堂集团股份有限公司) (2) Main financial information of significant associates ①Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. (焦作金冠嘉华电力有限公司) Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. (焦作金冠嘉华电力有限公司) Item Closing balance/ Current Beginning balance/ Prior year year Current assets 1,034,890,763.04 900,929,930.10 Including: Cash and cash equivalents 193,286,823.41 151,817,021.98 Non-current assets 274,836,800.49 295,290,603.34 Total assets 1,309,727,563.53 1,196,220,533.44 Current liabilities 734,194,376.70 621,231,810.54 Non-current liabilities 12,419,097.25 13,660,568.14 Total liabilities 746,613,473.95 634,892,378.68 Net assets 563,114,089.58 561,328,154.76 Including: Minority interests 0.00 0.00 Owners’ equity attributable to parent 563,114,089.58 561,328,154.76 company Net assets share calculated by shareholding 275,925,903.89 275,050,795.83 Adjustments Including: Goodwill Unrealized profit or loss in internal transactions Provision for impairment Others 9,612,591.63 9,569,113.18 Carrying value of equity investment in 285,538,495.52 284,619,909.02 associates Fair value of publicly quoted equity investments Continued: 265 Joincare Pharmaceutical Group Annual Report 2022 Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. (焦作金冠嘉华电力有限公司) Item Closing balance/ Current Beginning balance/ Prior year year Operating income 1,100,595,142.50 702,123,322.31 Financial expenses 16,069,876.59 14,968,954.50 Income tax expenses 15,013.60 -1,540,629.99 Net profit 1,785,934.82 -65,176,444.97 Net profit from discontinued operations Other comprehensive income Total comprehensive income 1,785,934.82 -65,176,444.97 Net cash flows from operating activities 132,858,948.24 -135,982,225.15 Dividends received from joint ventures in the current period ②Tianjin Tongrentang Group Co., Ltd. (天津同仁堂集团股份有限公司) Tianjin Tongrentang Group Co., Ltd. Item (天津同仁堂集团股份有限公司) 2022.12.31 Owners’ equity attributable to parent company 570,306,493.51 Net assets share calculated by shareholding 228,122,597.40 Adjustments Including: Goodwill 498,457,683.68 Carrying value of equity investment in associates 726,580,281.08 Fair value of publicly quoted equity investments Continued: Tianjin Tongrentang Group Co., Ltd. Item (天津同仁堂集团股份有限公司) Current year Operating income 1,086,062,042.02 Dividends received by the company from associates in the current 111,980,000.00 period The Company calculates the share of assets of associate based on the shareholding for the amount attributable to the parent company in the consolidated financial statements. The amounts in the consolidated financial statements of associates take into account the fair value of identifiable net assets and liabilities of associates at the time of acquisition and the impact of unified accounting policies. the above data is the preliminary results announcement of Tianjin Tongrentang. (3) Summary of financial information of other insignificant associates Closing balance/ Beginning balance/ Item Current year Prior year Associates: Total carrying amount of investment 407,763,817.99 1,134,729,545.83 The following amount are calculated on the basis of shareholding ratio Net profit -11,360,486.63 42,217,479.63 266 Joincare Pharmaceutical Group Annual Report 2022 Other comprehensive income 527,718.52 14,789,928.17 Total comprehensive income -10,832,768.11 57,007,407.80 (4) Significant limitations on the ability of joint ventures or associates to transfer funds to the Company None. VIII. Risks Management of Financial Instruments The major financial instruments of the Company include cash, bills receivable and accounts receivable, other receivables, non-current assets due within one year, other current assets, financial assets held for trading, other equity instrument investments, bills payable and accounts payable, other payables, short-term borrowings, financial liabilities held for trading, non-current liabilities due within one year, long-term borrowings and long-term payables. The details of these financial instruments are disclosed in the respective notes. The financial risk of these financial instruments and financial management policies used by the Company to minimize the risk are disclosed as below. The management of the Company manages and monitors the exposure of these risks to ensure the above risks are controlled in the limited range. 1. Management objectives and policies of risks The operation activities of the Company are subject to various financial risks: market risks (mainly including foreign exchange risks and interest rate risks), credit risks and liquidity risks. The Company formulates an overall risk management plan with respect to the unforeseeability of the financial market in order to minimise the potential adverse impacts on the financial performance of the Company. (1) Foreign exchange risks The Company conducts its operation primarily in China. Substantially all of the transactions were denominated and settled in Renminbi. However, the Company still has certain imports and exports businesses regarding APIs and diagnostic reagents that are settled in U.S. dollar and Japanese Yen. The Company’s businesses outside China (mainly in Hong Kong, India, Europe) are settled in Hong Kong dollars, U.S. dollar and Eurodollar. In addition, the Company will have foreign currency loans according to the operating needs. In respect of the above, the Company still exposes to certain foreign exchange risks. Taking into account the foreign exchange risks acceptable by the Company, the Company adopted Derivative instruments to control foreign exchange risk. However, as to the foreign exchange risk in loans, the Company shall closely monitor the trend of the exchange rate of Renminbi, and timely adjust the extent of borrowings, so as to minimise its risks. Financial assets and liabilities in foreign currencies held by the Company expressed in Renminbi are stated below: ① As at 31 December 2022 Unit: RMB 1,000 Item HKD USD EUR JPY GBP MOP CHF Financial assets in foreign currency - Cash and bank balances 689,008.76 1,795,183.72 702.84 18,052.98 16.29 4,272.78 0.00 Financial assets held for 87,193.75 0.00 0.00 0.00 0.00 0.00 0.00 trading Accounts receivable 0.00 498,180.41 0.00 0.00 0.00 1,097.96 0.00 Other receivables 2,849.00 0.15 0.00 0.00 0.00 504.53 0.00 Other current assets 0.00 92,815.74 0.00 0.00 0.00 0.00 0.00 Other equity instruments 524,464.51 0.00 0.00 0.00 0.00 0.00 0.00 investment 267 Joincare Pharmaceutical Group Annual Report 2022 Subtotal: 1,303,516.02 2,386,180.02 702.84 18,052.98 16.29 5,875.27 0.00 Financial liabilities in 0.00 0.00 0.00 0.00 0.00 0.00 0.00 foreign currency - Short-term loans 0.00 13,464.86 0.00 0.00 0.00 0.00 Accounts payable 0.00 3,569.18 42.05 14,627.29 0.00 0.00 141.89 Other payables 2,583.45 27,967.54 0.00 0.00 0.00 0.00 0.00 Subtotal: 2,583.45 45,001.58 42.05 14,627.29 0.00 0.00 141.89 ② As at 31 December 2021 Unit: RMB 1,000 Item HKD USD EUR JPY GBP MOP Financial assets in foreign currency - Cash and bank balances 516,034.78 1,296,568.06 559.42 2,406.62 16.70 1,121.33 Financial assets held for 163,071.45 0.00 0.00 0.00 0.00 0.00 trading Accounts receivable 0.00 579,062.08 4,493.18 0.00 0.00 2,824.85 Other receivables 2,712.73 0.00 0.00 0.00 0.00 461.23 Other equity instruments 480,531.75 0.00 0.00 0.00 0.00 0.00 investment Subtotal: 1,162,350.71 1,875,630.14 5,052.60 2,406.62 16.70 4,407.41 Financial liabilities in 0.00 0.00 0.00 0.00 0.00 0.00 foreign currency - Accounts payable 0.00 213.29 40.90 0.00 0.00 11.01 Other payables 2,503.18 16,034.63 0.00 0.00 0.00 0.00 Subtotal: 2,503.18 16,247.92 40.90 0.00 0.00 11.01 As at 31 December 2022, in respect of the Company’s financial assets and liabilities denominated in foreign currencies such as Hong Kong dollar, U.S. dollar, Euro, Japanese Yen and Macau dollar, should the value of RMB appreciate or depreciate by 5% against foreign currencies such as Hong Kong dollar, U.S. dollar, Euro, Japanese Yen and Macau dollar, and other factors remain unchanged, the Company would be subject to an increase or decrease in profit of approximately RMB182,597.36 (31 December 2021: approximately RMB151,553,060). (2) Interest rate risk The Company’s exposures to interest rate risk are mainly arising from interest-bearing liabilities such as bank borrowings. The interest rates are affected by the macro monetary policies of China, hence the Company will face the risks arising from fluctuation of interest rates in the future. The finance department of the head office of the Company continues to monitor the level of interest rate of the Company. The rise in the interest rate will increase the cost of additional interest-bearing liabilities and the interest expenses of the Company’s outstanding interest-bearing liabilities of which the interests are calculated at floating rates, and impose material adverse impact on the financial results of the Company. The management will make timely adjustment based on the updated market conditions. The directors of the Company consider that the future changes in the interest rate will have no material adverse impact on the operating results of the Company. (3) Credit risk Credit risk is primarily attributable to cash and cash equivalents, restricted funds, accounts receivables and other receivables. In respect of cash at banks, they were placed at several banks with good reputations, for 268 Joincare Pharmaceutical Group Annual Report 2022 which the credit risk was limited. In respect of receivables, the Company shall assess the credit limit granted to customers for credit purpose. Moreover, as the customer base of the Company is large, the credit risk on accounts receivables is not concentrated. In terms of bills receivable settlement, external payments are settled with bills receivable with priority and most of the remaining bills are high-quality bills with maturity within three months; thus none expected major credit risk exits. In addition, the provision made on the impairment of accounts receivables and other receivables are adequate to manage the credit risk. Among the accounts receivables of the Company, the accounts receivable of the top five customers accounted for 11.98% (31 December 2021: 11.60%); among the other receivables of the Company, the other receivables of the top five customers accounted for 46.23% (31 December 2021: 60.63%). (4) Liquidity risk The Company adopts prudent liquidity risk management for the sufficient supply of monetary funds and liquidity. It secures readily available credit loans from banks mainly by maintaining adequate monetary funds and banking facilities. Apart from indirect financing from banks, a number of financing channels were available, such as direct financing by inter-bank market including short-term financing bills and medium- term financing bills, corporate bonds etc. These instruments can effectively reduce the effects of scale of financing and the macro monetary policies of China on indirect bank financing, which shall secure adequate funds in a flexible manner. As at the date of the balance sheet, the contractual cash flows of financial assets and financial liabilities are presented below by term of maturity: ① As at 31 December 2022 Over 5 Item Within a year 1-2 years 2-5 years Total years Financial assets: Cash and bank balances 14,808,488,110.96 0.00 0.00 0.00 14,808,488,110.96 Financial assets held for 109,015,664.98 0.00 0.00 0.00 109,015,664.98 trading Notes receivable 1,959,985,016.85 0.00 0.00 0.00 1,959,985,016.85 Accounts receivable 3,103,758,850.15 0.00 0.00 0.00 3,103,758,850.15 Other receivables 52,535,740.14 0.00 0.00 0.00 52,535,740.14 Other current assets 104,859,166.96 0.00 0.00 0.00 104,859,166.96 Subtotal: 20,138,642,550.04 0.00 0.00 0.00 20,138,642,550.04 Financial liabilities: Short-term loans 2,126,050,615.06 0.00 0.00 0.00 2,126,050,615.06 Financial liabilities held 755,634.43 0.00 0.00 0.00 755,634.43 for trading Notes payable 1,635,906,989.22 0.00 0.00 0.00 1,635,906,989.22 Accounts payable 943,905,580.91 0.00 0.00 0.00 943,905,580.91 Other payables 3,680,334,360.88 0.00 0.00 0.00 3,680,334,360.88 Other current liabilities 83,541,891.93 0.00 0.00 0.00 83,541,891.93 Non-current liabilities due 63,077,260.98 0.00 0.00 0.00 63,077,260.98 within one year Lease liabilities 0.00 14,509,839.81 8,972,646.26 0.00 23,482,486.07 Long term loans 0.00 907,182,927.81 2,323,661,115.07 0.00 3,230,844,042.88 Subtotal: 8,533,572,333.41 921,692,767.62 2,332,633,761.33 0.00 11,787,898,862.36 269 Joincare Pharmaceutical Group Annual Report 2022 ② As at 31 December 2021 Item Within a year 1-2 years 2-5 years Over 5 years Total Financial assets: Cash and bank balances 11,729,230,390.98 0.00 0.00 0.00 11,729,230,390.98 Financial assets held for 184,638,344.31 0.00 0.00 0.00 184,638,344.31 trading Notes receivable 1,977,286,022.02 0.00 0.00 0.00 1,977,286,022.02 Accounts receivable 2,853,655,551.54 0.00 0.00 0.00 2,853,655,551.54 Other receivables 88,053,825.12 0.00 0.00 0.00 88,053,825.12 Non-current assets due 317,381.23 0.00 0.00 0.00 317,381.23 within one year Long-term receivables 0.00 266,904.13 0.00 0.00 266,904.13 Subtotal: 16,833,181,515.20 266,904.13 0.00 0.00 16,833,448,419.33 Financial liabilities: Short-term loans 2,518,484,835.09 0.00 0.00 0.00 2,518,484,835.09 Financial liabilities held 143,302.24 0.00 0.00 0.00 143,302.24 for trading Notes payable 1,582,386,767.93 0.00 0.00 0.00 1,582,386,767.93 Accounts payable 871,553,210.51 0.00 0.00 0.00 871,553,210.51 Other payables 3,292,407,989.79 0.00 0.00 0.00 3,292,407,989.79 Non-current liabilities due 91,576,066.33 0.00 0.00 0.00 91,576,066.33 within one year Lease liabilities 0.00 13,186,526.27 11,885,268.05 0.00 25,071,794.32 Long term loans 0.00 466,780,252.78 360,000,000.00 0.00 826,780,252.78 Subtotal: 8,356,552,171.89 479,966,779.05 371,885,268.05 0.00 9,208,404,218.99 2. Capital management The capital management policies are made to keep the continuous operation of the Company, to enhance the return to shareholders, to benefit other stakeholders and to maintain the best capital structure to minimize the cost of capital. For the maintenance or adjustment of the capital structure, the Company might adjust financing method, the amount of dividends paid to shareholders, return capital to shareholders, issue new shares and other equity instruments or make an asset disposal to reduce the liabilities. The Company monitors the capital structure with gearing ratio (calculated by dividing total liabilities by total assets). On 31 December 2022, the Company’s gearing ratio is 38.37% (31 December 2021: 35.12%). 3. Transfer of financial assets (1) Financial assets which are transferred but have not been derecognised in their entirety None. (2) Financial assets which have been transferred and ceased to be recognised but still have involvement with the transferor As at 31 December 2022, the Company discounted a banker's acceptance bill to the bank of RMB1,190,002,804.98 (previous period: RMB76,908,320.00). Since the principal risks and rewards, such as 270 Joincare Pharmaceutical Group Annual Report 2022 interest rate risks associated with these bankers' acceptances, have been transferred to the banks, the Company derecognizes discounted unmatured bankers' acceptance bills. According to the discount agreement, if the banker's acceptance bill is not accepted when due, the bank has the right to require the Company to pay the outstanding balance. As a result, the Company continued to engage in discounted bankers' acceptances, which amounted to RMB422,899,944.56 (31 December 2021: RMB67,908,033.05) as at 31 December 2022. As at 31 December 2022, the carrying value of the Company's unexpired bankers' acceptance bills endorsed to suppliers for settlement of accounts payable was RMB542,620,475.62 (31 December 2021: RMB186,290,992.91) and no outstanding commercial acceptance bills endorsed to suppliers for settlement of accounts payable (31 December 2021: Nil). In accordance with the Negotiable Instruments Law, the holders of the bills have a right of recourse against the Company if payment is refused by the bank of acceptance (the “Continuing Involvement”). The maturity date is within 1 to 6 months as at 31 December 2022, in the opinion of the Company, the Company has transferred substantially all risks and rewards. Accordingly, their full carrying amounts and the corresponding account payables have been derecognised. The maximum loss and the undiscounted cash flows from the Continuing Involvement and repurchasing is equal to their carrying amounts. In the opinion of the Company, the fair values of the Continuing Involvement are not significant. During the year ended 31 December 2022, no gain or loss was generated by the Company on the date of transfer of the bills. The Company had no current or accumulated gain or loss arising from the continuing involvement in financial assets which had been derecognised. The endorsement was incurred evenly throughout the period. IX. Fair value The level in which fair value measurement is categorised is determined by the level of the fair value hierarchy of the lowest level input that is significant to the entire fair value measurement. The levels are defined as follows: Level 1 inputs: unadjusted quoted prices in active markets that are observable at the measurement date for identical assets or liabilities. Level 2 inputs: inputs other than Level 1 inputs that are either directly or indirectly observable for underlying assets or liabilities. Level 3 inputs: inputs that are unobservable for underlying assets or liabilities. (1) Items and amounts measured at fair value As at 31 December 2022, the assets and liabilities measured at fair value are listed as follows according to the above three levels: Level 1 fair Level 2 fair Level 3 fair value Item value value Total measurement measurement measurement I. Recurring fair value measurement (1) Financial assets held for trading 103,583,153.41 5,432,511.57 0.00 109,015,664.98 1.debt instruments investment 934,289.94 0.00 0.00 934,289.94 2.equity instruments investment 102,648,863.47 0.00 0.00 102,648,863.47 3.Derivative financial assets 0.00 5,432,511.57 0.00 5,432,511.57 (2) Other equity instruments investment 9,615,483.94 0.00 1,184,343,395.11 1,193,958,879.05 Total assets measured at fair value on a 113,198,637.35 5,432,511.57 1,184,343,395.11 1,302,974,544.03 recurring basis (3) Financial liabilities held for trading Derivative financial liabilities 0.00 755,634.43 0.00 755,634.43 Total liabilities measured at fair value on 0.00 755,634.43 0.00 755,634.43 a recurring basis 271 Joincare Pharmaceutical Group Annual Report 2022 Level 1 fair Level 2 fair Level 3 fair value Item value value Total measurement measurement measurement II. Non-recurring fair value measurement Assets held-for-sale 0.00 0.00 0.00 0.00 Total assets measured at fair value on a 0.00 0.00 0.00 0.00 non-recurring basis Total liabilities measured at fair value on 0.00 0.00 0.00 0.00 a non-recurring basis During the year ended 31 December 2022, the Company’s investment LUNGLIFE AI, INC. was listed on the London Stock Exchange, as a result, the fair value measurement of this investment in other equity instruments transferred from level 3 to level 1; except for this investment in other equity instruments, tthere were no transfers of the fair value measurements between level 1 and level 2 and no transfers into or out of level 3. For the items in level 1 fair value measurement which listed on the Shanghai Stock Exchange, Shenzhen Stock Exchange, Hong Kong Stock Exchange or the United States, their fair value is determined based on the closing price on the last trading day of the reporting period. For the items in level 2 fair value measurement which uses valuation techniques and qualitative and quantitative information of important parameters to determine the fair value. For derivative financial instruments such as foreign exchange forward contracts, the fair value is determined based on the quoted forward exchange rate corresponding to the expiring contract. For the items in level 3 fair value measurement uses valuation techniques and qualitative and quantitative information of important parameters to determine the fair value. For some other equity instruments held, the fair value is based on the cost or the present value of the estimated future net cash flow as the best estimate. (2) Relevant information of level 2 fair value measurement Content Fair value as at 2022.12.31 Valuation techniques Calculated and determined based on the quoted forward Derivative financial assets 5,432,511.57 exchange rate corresponding to the expiring contract Derivative financial Calculated and determined based on the quoted forward 755,634.43 liabilities exchange rate corresponding to the expiring contract (3) Quantitative information of important unobservable input values used in level 3 of fair value measurement Fair value as at Content Valuation techniques 2022.12.31 Other equity instrument investments- (Shanghai Yunfeng Xinchuang 67,935,704.36 Net assets Equity Investment Center (上海云锋新创股权投资中心) Other equity instrument investments - Shanghai JingYi Investment 73,616,359.91 Net assets Center (上海经颐投资中心) (L.P.) Other equity instrument investments-Qianhai Equity Investment Fund 243,378,742.17 Net assets (前海股权投资基金) (L.P.) Other equity instrument investments -PANTHEOND,L.P. 5,954,301.20 Net assets Other equity instrument investments –Apricot Forest, Inc 120,788,500.00 Income method Other equity instrument investments –Zhuhai China Resources Bank 158,400,000.00 Market method Co., Ltd. (珠海华润银行股份有限公司) Other equity instrument investments - Yizun Biopharmaceutics 30,513,209.27 Market method (Shanghai) Co., Ltd. (羿尊生物医药(上海) 有限公司) ) Other equity instrument investments - Zhuhai Medpha Biotechnology 32,099,443.70 Recent financing price Co., Ltd. (珠海麦得发生物科技股份有限公司) ) ) Other equity instrument investments- Beijing Luzhu Biotechnology 53,654,738.60 Recent financing price Co., Ltd. (北京绿竹生物技术股份有限公司) Other equity instruments investment- Xiangrong (Shanghai) 19,613,667.00 Recent financing price Biotechnology Co., Ltd. (享融(上海) 生物科技有限公司) 272 Joincare Pharmaceutical Group Annual Report 2022 Fair value as at Content Valuation techniques 2022.12.31 Other equity instrument investments –GLOBAL HEALTH SCIENCE 271,980,388.15 Net assets Other equity instrument investments –SCC VENTURE VI 2018- 257,909.57 Net assets B,L.P. Other equity instrument investments –Nextech V Oncology S.C.S., 23,996,121.32 Net assets SICAV-SIF Other equity instrument investments -Others 82,154,309.86 Cost X. Related party and related party transactions 1. Information of parent company Shareholding ratio Voting right by Name of parent Place of Business nature Registered capital by parent company parent company company registration (%) (%) Shenzhen Investment and Baiyeyuan establishment of industry, Investment Co., Shenzhen domestic commerce, and 80,000,000.00 45.53 45.53 Ltd. (深圳市百业 material supply and 源投资有限公司) marketing The ultimate controller of the Company is Zhu Baoguo (朱保国). (1) Registered capital of parent company and its changes Name of parent company 2021.12.31 Increase Decrease 2022.12.31 Shenzhen Baiyeyuan Investment Co., Ltd. (深圳市百业源投资有限 80,000,000.00 0.00 0.00 80,000,000.00 公司) (2) Shares of the company held by the parent company and its changes Name of other related 2021.12.31 Ratio Increase Decrease 2022.12.31 Ratio parties Shenzhen Baiyeyuan Investment Co., Ltd. 895,653,653.00 46.95% 0.00 17,380,900.00 878,272,753.00 45.53% (深圳市百业源投资有 限公司) On 20 September 2022, Shenzhen Baiyeyuan Investment Co., Ltd. (深圳市百业源投资有限公司) lent 17,380,900 shares due to participating in the refinancing securities lending business, and the ownership of this part of the equity has not been transferred in the current period. 2. Subsidiaries of the Company Details of subsidiaries refer to Note VII. 1 3. Joint venture and associates of the Company Details of significant joint ventures or associates refer to Notes V.11 and VII. 2. Other joint ventures or associates entered into transactions with the Company during the period, or during the prior period with remaining closing balance were as follows: Name of joint ventures and associates Relationship with the Company Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. (焦作金冠 Associates 嘉华电力有限公司) 273 Joincare Pharmaceutical Group Annual Report 2022 Name of joint ventures and associates Relationship with the Company Guangdong Blue Treasure Pharmaceutical Co. Ltd. (广东蓝 Associates 宝制药有限公司) Novastage Pharmaceuticals (Shenzhen) , Ltd. (新领医药技 Associates 术(深圳) 有限公司) Shenzhen City Youbao Technology Co., Ltd. (深圳市有宝科 Associates 技有限公司) AbCyte Therapeutics Inc. Associates L&L Biopharma, Co. Ltd. (上海健信生物医药科技有限公 Associates 司) Zhuhai Sanmed Biotech Inc. (珠海圣美生物诊断技术有限 Associates 公司) Aetio Biotherapy Inc Associates Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd. (江苏 Associates 新元素医药科技有限公司) Tianjin Tongrentang Group Co., Ltd. (天津同仁堂集团股份 Associates 有限公司) Infinite Intelligence Pharmaceutical Co. Ltd. (北京英飞智药 Associates 科技有限公司) Shenzhen Kangti Biomedical Technology Co., Ltd. (深圳康 Associates 体生物医药科技有限公司) Shanghai Sheo Pharmaceutical Technology Co., Ltd. (上海偕 Associates 怡医药科技有限公司) Zhuhai Sanmed Gene Diagnostics Ltd. (珠海市圣美基因检 Entity controlled by an associate 测科技有限公司) Zhuhai Hengqin Weisheng Precision Medicine Technology Entity controlled by an associate Co., Ltd. (珠海横琴维胜精准医学科技有限公司) 4. Other related parties of the Company Name of other related parties Relationship with the Company Shenzhen Taitelixing Investment Development Co., Ltd. (深圳 Subsidiaries of the company’s ultimate actual controller 泰特力兴投资发展有限公司) Zhuozhou Jingnan Yongle Golf Club Co., Ltd. (涿州京南永乐 A company controlled by the Company’s parent company 高尔夫俱乐部有限公司) Shenzhen Healthy Deer Information Technology Co., Ltd. (深 An associate of the Company’s parent company 圳市健康阿鹿信息科技有限公司) Sichuan Healthy Deer Hospital Management Co., Ltd. and its A subsidiary of an associate of the Company’s parent subsidiaries (四川健康阿鹿医院管理有限公司及其子公司) company Zhuhai Medpha Biotechnology Co., Ltd. (珠海麦得发生物科 The supervisor of Livzon Group works as director for t 技股份有限公司) his entity Zhuhai Xianghetai Investment Management Partnership (Limited Partnership) (珠海祥和泰投资管理合伙企业(有限合 The executive of Livzon Group controls this entity 伙) ) Zhuhai Zhong Hui Yuan Investment Partnership (Limited The director of Livzon Group controls this entity Partnership) (珠海中汇源投资合伙企业(有限合伙) Zhuhai Liying Investment Management Partnership (Limited The director of Livzon Group controls this entity Partnership) (珠海丽英投资管理合伙企业(有限合伙) ) Jiangsu One Winner Medical Technology Co., Ltd. (江苏一赢 The director of Livzon Group controls this entity 家医疗科技有限公司) Zhuhai Pu Xiaoying Enterprise Management Co., Ltd. (Zhuhai The close family member of the director of Livzon Group Pu Xiaoying Enterprise Management Co., Ltd. (珠海市蒲小英 controls this entity 企业管理有限公司)) Directors, Supervisors and other senior management personnel Key management personnel 5. Related party transactions (1) Purchase or sale with related parties 274 Joincare Pharmaceutical Group Annual Report 2022 ①Purchase of goods/receiving of services Name of other related parties Nature of transaction Current year Prior year Guangdong Blue Treasure Pharmaceutical Co. Ltd. (广东 Raw materials 2,917,946.91 2,786,053.10 蓝宝制药有限公司) Zhuhai Sanmed Biotech Inc. (珠海圣美生物诊断技术有 Finished goods 0.00 28,558.55 限公司) Sichuan Healthy Deer Hospital Management Co., Ltd. and its subsidiaries (四川健康阿鹿医院管理有限公司及其 Finished goods, 0.00 887,872.67 Business promotion 子公司) Jiangsu One Winner Medical Technology Co., Ltd. (江苏 Business promotion 3,160,667.40 408,427.00 一赢家医疗科技有限公司) Zhuhai Sanmed Gene Diagnostics Ltd. (珠海市圣美基因 Testing 137,358.49 14,377.36 检测科技有限公司) L&L Biopharma, Co. Ltd. (上海健信生物医药科技有限 Research and 0.00 943,396.20 公司) development Shenzhen City Youbao Technology Co., Ltd. (深圳市有 Business promotion 2,083,948.00 1,062,850.00 宝科技有限公司) Zhuozhou Jingnan Yongle Golf Club Co., Ltd. (涿州京南 Member services 0.00 84,037.00 永乐高尔夫俱乐部有限公司) Infinite Intelligence Pharmaceutical Co. Ltd. (北京英飞智 Research and 339,805.83 148,514.85 药科技有限公司) development Zhuhai Pu Xiaoying Enterprise Management Co., Ltd. (珠 Modern services 249,975.00 0.00 海市蒲小英企业管理有限公司) Shanghai Sheo Pharmaceutical Technology Co., Ltd. (上 Research and 18,867,924.60 0.00 海偕怡医药科技有限公司) development Feellife Health Inc. (深圳来福士雾化医学有限公司) Nebulizer 902,115.48 0.00 Jiaozuo Jinguan Jiahua Electric Power Co., Ltd. (焦作金 Electricity, Steam 268,666,999.03 212,585,953.81 冠嘉华电力有限公司) Total 297,326,740.74 218,950,040.54 ②Sales of goods/rendering of services Name of related parties Nature of transaction Current year Prior year Guangdong Blue Treasure Pharmaceutical Co. Ltd. (广 Finished Products, 35,703,972.73 63,972,886.45 东蓝宝制药有限公司) Hydropower and Power Zhuhai Sanmed Biotech Inc. (珠海圣美生物诊断技术 Finished Products, Hydropower, Power and 1,435,666.13 577,453.14 有限公司) others Sichuan Healthy Deer Hospital Management Co., Ltd. and its subsidiaries (四川健康阿鹿医院管理有限公司 Finished Products 3,036,532.62 4,951,551.99 及其子公司) Zhuhai Sanmed Gene Diagnostics Ltd. (珠海市圣美基 Finished Products, Hydropower, Power and 592,356.49 667,998.89 因检测科技有限公司) others Shanghai Sheo Pharmaceutical Technology Co., Ltd. Research and 3,960,000.00 0.00 (上海偕怡医药科技有限公司) development Total 44,728,527.97 70,169,890.47 (2) Rental with related party Type of assets Rental income in current Rental income in prior Name of lessee leased year year Zhuhai Sanmed Biotech Inc. (珠海圣美生 Buildings 2,226,299.00 2,226,299.00 物诊断技术有限公司) Zhuhai Sanmed Gene Diagnostics Ltd. (珠 Buildings 240,000.00 240,000.00 海市圣美基因检测科技有限公司) 275 Joincare Pharmaceutical Group Annual Report 2022 Type of assets Rental income in current Rental income in prior Name of lessee leased year year Shenzhen Baiyeyuan Investment Co., Ltd. Buildings 18,891.76 18,891.76 (深圳市百业源投资有限公司) Novastage Pharmaceuticals (Shenzhen) , Buildings & 468,302.76 315,457.80 Ltd. (新领医药技术(深圳) 有限公司) Equipment Shenzhen Taitelixing Investment Development Co., Ltd. (深圳泰特力兴投 Buildings 18,720.00 18,720.00 资发展有限公司) Shenzhen Healthy Deer Information Technology Co., Ltd. (深圳市健康阿鹿信 Buildings 17,174.32 17,174.32 息科技有限公司) Shenzhen City Youbao Technology Co., Buildings 17,174.32 17,174.32 Ltd. (深圳市有宝科技有限公司) Total 3,006,562.16 2,853,717.20 (3) Guarantee with related parties ① In order to ensure the stable development of production and operation of Jinguan Electric Power, the Company and its controlling subsidiary Jiaozuo Joincare jointly provided a revolving guarantee facility with balance of no more than RMB350 million (inclusive) for Jinguan Electric Power (specific guarantors shall be specified in the guarantee contracts) according to “the Resolution on Providing Loan Guarantee for Jinguan Electric Power by the Company and Its Controlling Subsidiary Jiaozuo Joincare” considered and approved at the First Extraordinary General Meeting of the Company on 6 July 2016, with the guarantee period starting from the date when the resolution was considered and approved to 31 December 2019. Pursuant to “the Resolution on Providing Loan Guarantee for Jinguan Electric Power by the Company and Its Controlling Subsidiary Jiaozuo Joincare” considered and approved at the 2017 Annual General Meeting of the Company on 22 May 2018, the Company and its controlling subsidiary Jiaozuo Joincare jointly provided a revolving guarantee facility with balance of no more than RMB350 million (inclusive) for Jinguan Electric Power (specific guarantors shall be specified in the guarantee contracts), with the guarantee period starting from the date when the resolution was considered and approved to 31 December 2022. In order to ensure the stable development of production and operation of Jinguan Electric Power, the revolving guarantee facility with balance of no more than RMB350 million (inclusive) for Jinguan Electric Power (specific guarantors shall be specified in the guarantee contracts) considered and approved at the 2017 General Meeting of the Company was changed to the revolving guarantee facility with balance of no more than RMB450 million (inclusive) on 10 May 2019 due to the actual business needs of Jinguan Electric Power, with the guarantee period starting from the date when the resolution was considered and approved to 31 December 2022. On 18 May 2022, the "Proposal on the Company and its subsidiary Jiaozuo Joincare in Providing Loan Guarantee for Jinguan Electric Power" was reviewed and approved by the Company's 2021 annual general meeting, the Company and its subsidiary Jiaozuo Joincare jointly provided a guarantee for Jinguan Electric Power on its revolving loans facility with a balance of not more than RMB450 million (including RMB450 million) (the specific guarantor will be specified in each guarantee contract), and the term is from the date of approval of this guarantee proposal at the Company’s annual general meeting to 31 December 2025. As at 31 December 2022, the Company provided Jinguan Electric Power with guarantees for loans of RMB378.40 million; of which RMB222 million in Shenzhen Branch of China Everbright Bank, RMB90 million in Shenzhen Branch of Zheshang Bank, RMB46.40 million in Shenzhen Branch of Nanyang Commercial Bank and RMB20 million in Jiaozuo Branch of China CITIC Bank. In order to ensure the safety of secured loans, Jinguan Electric Power provided counter guarantees for the said guarantees provided by the Company and its subsidiary, Jiaozuo Joincare, based on its owned assets, and undertook that it would unconditionally provide mutual guarantees for the Company or its controlling subsidiary designated with total facility of no more than RMB450 million (inclusive) whenever the Company deemed necessary. ② Another shareholder of Livzon MABPharm Inc. (珠海市丽珠单抗生物技术有限公司) – the Company has issued a "Counter Guarantee Commitment", promising that it will share the joint and several guarantee liability to the extent of 33.07% of the scope of guarantee responsibility in relation to the guarantee provided 276 Joincare Pharmaceutical Group Annual Report 2022 to Livzon MABPharm Inc. (珠海市丽珠单抗生物技术有限公司), and the counter guarantee period will expire on the date when the Company's guarantee responsibility expiry. ③ Zhuhai Zhong Hui Yuan Investment Partnership (Limited Partnership) (珠海中汇源投资合伙企业(有限 合伙), being another shareholder of Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc. (丽珠集 团新北江制药股份有限公司) has issued a "Counter Guarantee Commitment", promising that it will share the joint and several guarantee liability to the extent of 8.44% of the scope of guarantee responsibility incurred by Livzon Group in relation to the guarantee provided to Livzon MABPharm Inc. (珠海市丽珠单抗生物技 术有限公司), and the counter guarantee period will expire on the date when Livzon Group's guarantee responsibility expiry. (4) Asset transfer and debt restructuring between related parties None. (5) Remuneration of key management personnel Unit: RMB ten thousand For the year ended 31 December 2022 Director/ Wages and Social Housing Severance Supervisor Bonus Others Total allowances security fund pay Allowance Directors: Zhu Baoguo 325.00 0.00 6.44 2.66 0.00 0.00 0.00 334.09 (朱保国) Liu Guangxia 325.00 18.48 1.85 2.66 0.00 0.00 0.00 347.98 (刘广霞) Yu Xiong (俞 0.00 260.00 0.00 0.00 100.00 0.00 0.00 360.00 雄) Qiu Qingfeng 0.00 135.00 7.27 2.66 80.00 0.00 0.00 224.93 (邱庆丰) Lin Nanqi (林 0.00 135.00 7.27 2.66 80.00 0.00 0.00 224.93 楠棋) Cui Liguo (崔 11.54 0.00 0.00 0.00 0.00 0.00 0.00 11.54 利国) Huo Jing (霍 11.54 0.00 0.00 0.00 0.00 0.00 0.00 11.54 静) Qin Yezhi (覃 11.54 0.00 0.00 0.00 0.00 0.00 0.00 11.54 业志) Peng Juan (彭 11.54 0.00 0.00 0.00 0.00 0.00 0.00 11.54 娟) Supervisors: Yu Xiaoyun (余 4.80 38.31 6.82 2.25 17.95 0.00 0.00 70.13 孝云) Peng Jinhua (彭 4.80 0.00 0.00 0.00 0.00 0.00 0.00 4.80 金花) Xing Zhiwei 2.97 64.00 6.82 2.09 93.00 0.00 0.00 168.88 (幸志伟) Xie Youguo (谢 1.83 36.92 0.00 0.00 0.00 0.00 0.00 38.75 友国) Other senior management: Zhao Fenguang 0.00 135.00 7.27 2.66 45.00 0.00 0.00 189.93 (赵凤光) Total 710.57 822.71 43.75 17.61 415.95 0.00 0.00 2,010.58 277 Joincare Pharmaceutical Group Annual Report 2022 Note: Mr. Zhu Baoguo (朱保国) serves as the chairman of Livzon Group, a controlled subsidiary of the Company; and Mr. Yu Xiong (俞雄) and Mr. Qiu Qingfeng (邱庆丰) serve as non-executive directors of Livzon Group. Xie Youguo (谢友国) has resigned. The remuneration presented in above does not include the portion paid by Livzon Group. For the year ended 31 December 2021 Director/ Wages and Social Housing Severance Supervisor Bonus Others Total allowances security fund pay Allowance Directors: Zhu Baoguo 330.94 0.00 6.22 2.40 0.00 0.00 0.00 339.56 (朱保国) Liu Guangxia 330.94 17.91 8.01 2.40 0.00 0.00 0.00 359.27 (刘广霞) Yu Xiong 0.00 240.00 0.00 0.00 95.00 0.00 0.00 335.00 (俞雄) Qiu Qingfeng 0.00 135.00 6.22 2.40 30.00 0.00 0.00 173.62 (邱庆丰) Lin Nanqi 0.00 135.00 6.22 2.40 30.00 0.00 0.00 173.62 (林楠棋) Cui Liguo 10.00 0.00 0.00 0.00 0.00 0.00 0.00 10.00 (崔利国) Huo Jing 10.00 0.00 0.00 0.00 0.00 0.00 0.00 10.00 (霍静) Qin Yezhi 10.00 0.00 0.00 0.00 0.00 0.00 0.00 10.00 (覃业志) Peng Juan 3.60 0.00 0.00 0.00 0.00 0.00 0.00 3.60 (彭娟) Supervisors: Yu Xiaoyun (余 4.00 38.16 6.01 2.18 17.95 0.00 0.00 68.29 孝云) Peng Jinhua (彭 4.00 32.73 0.00 1.36 0.00 0.00 0.00 38.09 金花) Xie Youguo 4.00 36.35 0.00 1.17 2.86 0.00 0.00 44.38 (谢友国) Other senior management: Zhao Fenguang 0.00 135.00 6.22 2.40 25.00 0.00 0.00 168.62 (赵凤光) Total 707.48 770.14 38.88 16.74 200.81 0.00 0.00 1,734.05 Note: Mr. Zhu Baoguo (朱保国) serves as the chairman of Livzon Group, a controlled subsidiary of the Company; and Mr. Yu Xiong (俞雄) and Mr. Qiu Qingfeng (邱庆丰) serve as non-executive directors of Livzon Group. The remuneration presented in above does not include the portion paid by Livzon Group. (6) Other related party transactions None. 6. Receivables and payables with related party (1) Receivable from related parties 278 Joincare Pharmaceutical Group Annual Report 2022 2022.12.31 2021.12.31 Item Related party Provision Provision for Book balance Book balance for bad bad debts debts Notes Guangdong Blue Treasure Pharmaceutical Co. 3,893,820.00 0.00 5,492,960.00 0.00 receivable Ltd. (广东蓝宝制药有限公司) Accounts Guangdong Blue Treasure Pharmaceutical Co. 4,781,500.00 47,336.85 18,889,500.00 490,875.00 receivable Ltd. (广东蓝宝制药有限公司) Accounts Zhuhai Sanmed Gene Diagnostics Ltd. (珠海 85,731.98 840.17 224,023.83 8,578.07 receivable 市圣美基因检测科技有限公司) Sichuan Healthy Deer Hospital Management Accounts Co., Ltd. and its subsidiaries (四川健康阿鹿 497,828.30 103,325.48 337,395.02 48,933.97 receivable 医院管理有限公司及其子公司) Zhuhai Sanmed Biotech Inc. (珠海圣美生物 Prepayments 211,200.00 0.00 211,200.00 0.00 诊断技术有限公司) Shenzhen City Youbao Technology Co., Ltd. Prepayments 188,100.00 0.00 154,500.00 0.00 (深圳市有宝科技有限公司) Jiaozuo Jinguan Jiahua Electric Power Co., Prepayments 75,724,913.57 0.00 8,240,517.56 Ltd. (焦作金冠嘉华电力有限公司) Other Zhongshan Renhe Health Products Co., Ltd. 469,895.78 469,895.78 469,895.78 469,895.78 receivables (中山市仁和保健品有限公司) Other Shenzhen Jiekang Health Care Co., Ltd. (深圳 18,577,246.6 0.00 0.00 18,577,246.63 receivables 市捷康保健有限公司 ) 3 Shenzhen Healthy Deer Information Other Technology Co., Ltd. (深圳市健康阿鹿信息 4,680.00 74.38 4,680.00 74.38 receivables 科技有限公司) Other Guangdong Blue Treasure Pharmaceutical Co. 607,484.29 6,925.32 1,271,496.55 21,233.99 receivables Ltd. (广东蓝宝制药有限公司) Other Zhuhai Sanmed Gene Diagnostics Ltd. (珠海 15,795.00 170.59 5,265.00 87.93 receivables 市圣美基因检测科技有限公司) (2) Payables to related party Item Related party 2022.12.31 2021.12.31 Guangdong Blue Treasure Pharmaceutical Co. Ltd. (广东蓝 Notes payable 0.00 379,960.00 宝制药有限公司) Sichuan Healthy Deer Hospital Management Co., Ltd. and its Contract liabilities 12,011.72 0.00 subsidiaries (四川健康阿鹿医院管理有限公司及其子公司) Sichuan Healthy Deer Hospital Management Co., Ltd. and its Other payables 8,936.17 8,936.17 subsidiaries (四川健康阿鹿医院管理有限公司及其子公司) XI. Share-based payments 1. Information about share-based payments (1) The Company Item Related content Total amount of equity instruments granted during the year (shares) 49,450,000 Total amount of equity instruments exercised during the year (shares) 8,596,134 Total amount of equity instruments forfeited during the year (shares) 26,000 Range of exercise price and residual life of outstanding share options at the end of the Note year Range of exercise price and residual life of outstanding other equity instruments at the end — of the year Note: Share Option 279 Joincare Pharmaceutical Group Annual Report 2022 ① On 29 August 2022, the Company held the third extraordinary general meeting of shareholders in 2022, and reviewed and approved the "Proposal on the Company's 2022 Stock Option Incentive Plan (Draft) and its Summary", Proposal on the Company's 2022 Stock Option Incentive Plan Implementation Appraisal Management Measures" and "Proposal on Requesting the Company's Shareholders' Meeting to Authorize the Board of Directors to Handle Matters Related to Shares Incentive". The Company held the 16th meeting of the eighth board of directors on 5 September 2022, and reviewed and passed the "Proposal on First Time Granting Stock Options to Incentive Participants". With 5 September 2022 as the grant date, 49.45 million stock options were granted to 423 incentive participants at a price of RMB11.24 per share. The date of completion and effective date of registration of stock options granted is 16 September 2022. The exercise period of the options granted this time and the exercise time schedule for each period are shown in the following table: Vesting period Vesting date Vesting ratio From the first trading day 12 months after the first grant date to the last First vesting period 40% trading day within 24 months from the first grant date From the first trading day 24 months after the first grant date to the last Second vesting period 30% trading day within 36 months from the first grant date From the first trading day 36 months after the first grant date to the last Third vesting period 30% trading day within 48 months from the first grant date Company-level performance appraisal requirements: The stock options granted by this incentive plan are subject to annual performance appraisal and vesting. To achieve the performance appraisal target as the vesting condition for incentive participants, the annual performance appraisal targets for the first-time grant are shown in the table below: Vesting period Performance appraisal targets Based on the net profit in 2021, the compound growth rate of net profit in 2022 shall not be First vesting period less than 15%; Based on the net profit in 2021, the compound growth rate of net profit in 2023 shall not be Second vesting period less than 15%; Based on the net profit in 2021, the compound growth rate of net profit in 2024 shall not be Third vesting period less than 15%. The calculation of the above "net profit" and "net profit growth rate" indicators is based on the net profit attributable to shareholders of listed company after deducting non-recurring gains and losses, and excluding the impact of share-based payments in this incentive plan. If the Company fails to meet the above-mentioned performance appraisal targets, all incentive participants whose stock options are exercisable in the year corresponding to the appraisal shall not be exercised and shall be canceled by the Company. ② On 13 December 2018, the Company held the third extraordinary general meeting of shareholders in 2018, and reviewed and approved the "Proposal on the Company's 2018 Stock Option Incentive Plan (Draft) and its summary". The stock options granted for the first time was granted on 21 December 2018, with a grant price of RMB8.21 per share, and would expire on 20 December 2022. The reserved stock options were granted on 23 September 2019, with a grant price of RMB10.47 per share, and would expire on 22 September 2022. (2) The Company’s subsidiary, Livzon Group Total amount of equity instruments granted during the year (shares) 17,973,500 Total amount of equity instruments exercised during the year (shares) 1,091,966 Total amount of equity instruments forfeited during the year (shares) 4,905,012 Range of exercise price and residual life of outstanding share options at the end of the year Note 1 Range of exercise price and residual life of outstanding other equity instruments at the end Note 2 of the year Note 1:Share Option ① On 14 October 2022, Livzon Group’s 2022 Second Extraordinary Shareholders’ Meeting, 2022 Second 280 Joincare Pharmaceutical Group Annual Report 2022 A-Share Class Shareholders’ Meeting and 2022 H-Share Class Shareholders’ Meeting reviewed and approved the “Proposal on the Company's 2022 Stock Option Incentive Plan (Revised Draft) and Its Summary", "Proposal on the company's 2022 Stock Option Incentive Plan Implementation Appraisal Management Measures", "Proposal on submitting to the company's general meeting of shareholders to authorize the board of directors to handle matters related to the 2022 stock options incentive plan". On 7 November 2022, the 39th meeting of the 10th Board of Directors of Livzon Group reviewed and approved the "Proposal on Matters Related to the First Time Grant of the 2022 Stock Option Incentive Plan". With 7 November 2022 as the grant date, 17,973,500 stock options were granted to 1,026 incentive participants at a price of RMB31.31 per A share. The date of completion and effective date of registration of stock options granted is 23 November 2022. The exercise period of the options granted this time and the exercise time schedule for each period are shown in the following table: Vesting period Vesting date Vesting ratio First vesting period of From the first trading day 12 months after the completion of the first time stock options granted grant registration to the last trading day within 24 months from the 40% for the first time completion of the first time grant registration Second vesting period From the first trading day 24 months after the completion of the first time of stock options granted grant registration to the last trading day within 36 months from the 30% for the first time completion of the first time grant registration Third vesting period of From the first trading day 36 months after the completion of the first time stock options granted grant registration to the last trading day within 48 months from the 30% for the first time completion of the first time grant registration Livzon Group performance appraisal requirements: The stock options granted by this incentive plan are subject to annual performance appraisal and vesting during the 3 fiscal years of the vesting period. To achieve the performance appraisal target as the vesting condition for incentive participants, the annual performance appraisal targets for the first-time grant are shown in the table below: Vesting period Performance appraisal targets First vesting period of stock options Based on the net profit in 2021, the compound growth rate of net profit in 2022 granted for the first time shall not be less than 15%; Second vesting period of stock options Based on the net profit in 2021, the compound growth rate of net profit in 2023 granted for the first time shall not be less than 15%; Third vesting period of stock options Based on the net profit in 2021, the compound growth rate of net profit in 2024 granted for the first time shall not be less than 15%. The calculation of the above "net profit" and "net profit compound growth rate" indicators is based on the net profit attributable to shareholders of listed company after deducting non-recurring gains and losses, and excluding the impact of share-based payments in this incentive plan. If the Company fails to meet the above- mentioned performance appraisal targets, all incentive participants whose stock options are exercisable in the year corresponding to the appraisal shall not be exercised and shall be canceled by the Company. ② On 5 September 2018, Livzon Group’s 2018 Third Extraordinary Shareholders’ Meeting, the 2018 Third A-Share Class Shareholders’ Meeting and the 2018 H-Share Class Shareholders’ Meeting reviewed and approved the “Proposal on the Company's 2018 Stock Option Incentive Plan (Revised Draft) and its Summary”. The stock options granted for the first time was granted on 11 September 2018, with a grant price of RMB47.01 per share, and would expire on 23 September 2022. The reserved stock options were granted on 28 August 2019, with a grant price of RMB28.87 per A-share, and would expire on 26 October 2022. Note 2: Other equity incentive Pursuant to “ the Resolution on the Disposal of Certain Equity of a Holding Subsidiary and Connected Transaction” considered and approved at the 34th Meeting of the 9th Session of the Board of Livzon Group on 8 November 2019, it was agreed that 9.5% equity interests (totally 8,382,100 shares) in Zhuhai Livzon Diagnostics Inc. (珠海丽珠试剂股份有限公司) held by Livzon Group shall be transferred to Zhuhai Liying Investment Management Partnership (Limited Partnership) (珠海丽英 投资管理合伙企业(有限合伙)) at the consideration of RMB21,122,892. Pursuant to the Assets Appraisal Report on the Valuation of the Shareholders'. According to “Assets evaluation report of all shareholders' equity value project of Zhuhai 281 Joincare Pharmaceutical Group Annual Report 2022 Livzon Diagnostics Inc. (珠海丽珠试剂股份有限公司) involved in the proposed transfer of equity by Livzon Pharmaceutical Group Co., Ltd.”. (Huaya Zhengxin Appraisal Report [2019] No. A02-0011), the valuation of all shareholders’ equity of Zhuhai Livzon Diagnostics Inc. as at 30 June 2019 was RMB647.3075 million, and the above equity transfer price was lower than its fair value, therefore it constitutes a share-based payment. The total share-based payment of the transaction is RMB40.4017 million, which should be amortized within 5 years according to the partnership agreement and share incentive expenses were recognised due to the share- based payment as a result of the change in the shareholding of the shareholders of Zhuhai Liying Investment Management Partnership (Limited Partnership). Pursuant to “the Resolution on the Implementation of Employee Equity Incentive Scheme by a Holding Subsidiary” considered and approved at the 34th Meeting of the 9th Session of the Board of Livzon Group on 8 November 2019, the total number of shares of new issuance by Zhuhai Livzon Diagnostics Inc. for implementation of employee equity incentive scheme shall not be more than 4,643,839 shares, and the scheme participants shall contribute a total of RMB11,702,474.28 to directly subscribe for the above shares or indirectly subscribe for the such shares through the holding of the limited partnership shares of the employee shareholding platform. In December 2019, pursuant to the Capital Increase Agreement of Zhuhai Livzon Diagnostics Inc., the total shares of Zhuhai Livzon Diagnostics Inc. increased from 88,232,932 shares to 92,876,771 shares with par value of RMB1 per share. The increased number of shares were subscribed for by Zhuhai Haoxun Enterprise Management Consulting Partnership (Limited Partnership) (珠海豪汛企业管 理咨询合伙企业(有限合伙)), Zhuhai Yichen Enterprise Management Consulting Partnership (Limited Partnership) (珠海熠臣企业管理咨询合伙企业(有限合伙)) and Zhuhai Qijing Enterprise Management Consulting Partnership (Limited Partnership) (海启靖企业管理咨询合伙企业(有限合伙)) at the consideration of RMB11,702,474. The subscription price is lower than the fair value, therefore it constitutes a share-based payment. The total share-based payment of the transaction is RMB20,709,000, which should be amortized within 5 years according to the Partnership Agreement, and share incentive expenses were recognized due to the share-based payment as a result of the change in the shares/shareholding of the shareholders or employee stock ownership platform of Zhuhai Livzon Diagnostics Inc. On 31 August 2021, the general meeting of Livzon Bio considered and approved the Equity Incentive Scheme of Zhuhai Livzon Biotechnology Co., Ltd. (珠海市麗珠生物醫藥科技有限公司), granting 66,666,667 restricted shares of Livzon Biologics to incentive participants, among which 42 million shares were granted in the first batch and 24,666,667 shares were reserved. Incentive participants indirectly subscribed for the above shares through the holding of the limited partnership shares of the employee shareholding platform. The subscription price is lower than the fair value, therefore it constitutes a share-based payment. The total share-based payment of the transaction is RMB33.6 million, which should be amortized during the lock-up period according to the Equity Incentive Scheme of LivzonBio and the Grant Agreement and RMB16.24 million was amortized in the 6-month period ended 30 June 2022. 2. Equity-settled share-based payments Method in determining the fair value of equity instruments at the date Black-Scholes Model, market price of grant Basis in determining the quantity of exercisable equity instruments — Reason for significant difference of estimation between current year None and prior year Accumulated amount recorded in capital reserve for equity-settled 194,032,737.35 share-based payments Total expenses recognized for equity-settled share-based payments in 57,076,979.08 the year 3. Information on cash-settled share-based payments None. XII. Commitments and contingencies 1. Significant commitments 282 Joincare Pharmaceutical Group Annual Report 2022 (1) Capital commitments Capital commitments entered into but not recognized in the Closing balance Beginning balance financial statements Commitments in relation to acquisition of long-term assets 455,161,816.72 582,336,168.87 Commitments in relation to external investment 12,000,000.00 8,000,000.00 Commitments in relation to research and development 0.00 309,313,880.64 expenditures (2) Other commitments None. (3) Performance of previous commitments The Company has duly performed the capital expenditure commitments and the operating lease commitments and the other commitments as at 31 December 2022. 2. Contingencies As at 31 December 2022, there was no other significant contingency required to be disclosed by the Company. XIII. Event after balance sheet date 1. Profit distribution On 7 April 2023, the twenty-third meeting of the eighth Board of Directors of the Company passed the 2022 profit distribution plan. Based on the Company's total share capital deducted by the repurchased shares held in the Company's special securities account on the registration date determined by the implementation of the Company's 2022 annual profit distribution plan, a cash bonus of RMB1.80 (tax included) for every 10 shares will be distributed to all shareholders. The above profit distribution plan needs to be submitted to the company's 2023 annual general meeting of shareholders for consideration and approval. As of 7 April 2023, the Company has no other events that needed to be disclosed after the balance sheet date. XIV. Other significant events 1. Leases The Company had adopted a simplified approach for short-term leases and leases of low value assets and did not recognize right-of-use assets and lease liabilities. The expense of short-term leases, leases of low value assets and variable lease payments not included in the measurement of lease liabilities are included in the expenses in the current period as follows: Item 2022 Short-term leases 2,583,258.77 As of the balance sheet date, except for the above matters, the Company does not have other important matter to be disclosed. XV. Notes to the significant financial statements item of the Parent Company 1. Notes receivable 283 Joincare Pharmaceutical Group Annual Report 2022 2022.12.31 2021.12.31 Category Provision Provision Carrying Carrying Book balance for bad Book balance for bad amount amount debts debts Bank acceptance 249,617,024.89 0.00 249,617,024.89 374,296,302.21 0.00 374,296,302.21 bills Commercial acceptance 0.00 0.00 0.00 0.00 0.00 0.00 bills Total 249,617,024.89 0.00 249,617,024.89 374,296,302.21 0.00 374,296,302.21 (1) Notes receivable pledged at year end Category Amount pledged at year end Bank acceptance bills 196,148,535.27 (2) Bills endorsed or discounted to other parties but not yet expired at balance sheet date Amount derecognized at year Amount not derecognized at year Category end end Bank acceptance bills not yet mature but 287,052,316.14 -- already endorsed Bank acceptance bills not yet mature but 81,834,471.01 -- already discounted Total 368,886,787.15 (3) There was no bills transferred into account receivables for non-performance by the issuer at balance sheet date of the period. (4) Disclosure by method of provision for bad debts 2022.12.31 2021.12.31 Provision for bad Book balance Provision for bad debts Book balance Category debts Carrying Expecte Carrying Expected value value d credit Amount Ratio (%) Amount credit loss Amount Ratio (%) Amount loss rate rate (%) (%) Provision for bad debts on individual item Provision for bad debts on 249,617,024.89 100.00 0.00 0.00 249,617,024.89 374,296,302.21 100.00 0.00 0.00 374,296,302.21 portfolio basis Including: Bank acceptance bills 249,617,024.89 100.00 0.00 0.00 249,617,024.89 374,296,302.21 100.00 0.00 0.00 374,296,302.21 Total 249,617,024.89 100.00 0.00 0.00 249,617,024.89 374,296,302.21 100.00 0.00 0.00 374,296,302.21 (5) There was no accrual, recovery or reversal of bad debt provision during the period (6) There was no actual write-off of notes receivable in the period 2. Accounts receivable (1) Disclosure by ageing Ageing 2022.12.31 2021.12.31 Within one year 290,962,991.84 538,967,095.90 1 to 2 years (inclusive of 2 years) 2,684,445.48 1,410,787.21 2 to 3 years (inclusive of 3 years) 1,178,173.47 733,293.23 284 Joincare Pharmaceutical Group Annual Report 2022 Ageing 2022.12.31 2021.12.31 3 to 4 years (inclusive of 4 years) 641,804.42 388,712.49 4 to 5 years (inclusive of 5 years) 388,712.49 360,879.34 Over 5 years 7,754,530.87 7,723,623.65 Subtotal 303,610,658.57 549,584,391.82 Less: Provision for bad debts 11,979,800.83 14,041,321.58 Total 291,630,857.74 535,543,070.24 (2) Disclosure by method of provision for bad debts 2022.12.31 2021.12.31 Book balance Provision for bad debts Book balance Provision for bad debts Category Carrying Carrying Expected Expected Ratio value Ratio value Amount Amount credit loss Amount Amount credit loss (%) (%) rate (%) rate (%) Provision for bad debts on 771,300.68 0.25 771,300.68 100.00 0.00 771,300.68 0.14 771,300.68 100.00 0.00 individual item Including: Receivables from domestic 771,300.68 0.25 771,300.68 100.00 0.00 771,300.68 0.14 771,300.68 100.00 0.00 customers Receivables from overseas 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 customers Provision for bad debts on 302,839,357.89 99.75 11,208,500.15 3.70 291,630,857.74 548,813,091.14 99.86 13,270,020.90 2.42 535,543,070.24 portfolio basis Including: Receivables from domestic 302,839,357.89 99.75 11,208,500.15 3.70 291,630,857.74 548,813,091.14 99.86 13,270,020.90 2.42 535,543,070.24 customers Receivables from overseas 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 customers Total 303,610,658.57 100 11,979,800.83 3.95 291,630,857.74 549,584,391.82 100 14,041,321.58 2.55 535,543,070.24 Provision for bad debts on individual item: 2022.12.31 Name Provision for bad Expected credit Book balance Reason of provision debts loss rate (%) Not expected to be Purchase of goods 771,300.68 771,300.68 100.00 recoverable Total 771,300.68 771,300.68 100.00 Provision for bad debts on portfolio basis: Provision for bad debts on portfolio basis:Receivables from domestic customers 2022.12.31 2021.12.31 Expected Expected Accounts Provision for Accounts Provision for credit loss credit loss receivable bad debts receivable bad debts rate (%) rate (%) Within one year 290,962,991.84 2,721,949.54 0.94 538,967,095.90 5,259,670.96 0.98 1 to 2 years (inclusive 2,684,445.48 282,436.48 10.52 1,410,787.21 150,539.36 10.67 of 2 years) 285 Joincare Pharmaceutical Group Annual Report 2022 2 to 3 years (inclusive 1,178,173.47 378,821.59 32.15 733,293.23 239,987.97 32.73 of 3 years) 3 to 4 years (inclusive 641,804.42 474,608.03 73.95 103,939.29 81,969.65 78.86 of 2 years) 4 to 5 years (inclusive 103,939.29 82,681.12 79.55 300,612.74 240,490.19 80.00 of 3 years) Over 5 years 7,268,003.39 7,268,003.39 100.00 7,297,362.77 7,297,362.77 100.00 Subtotal 302,839,357.89 11,208,500.15 3.70 548,813,091.14 13,270,020.90 2.42 (3) Accrual, recovery or reversal of bad debt provision during the period Amount of provision for bad debts Beginning balance 14,041,321.58 Provision for the year -2,061,520.75 Recovered or reversal in the year 0.00 Write-off in the year 0.00 Closing balance 11,979,800.83 At 31 December 2022 and 31 December 2021, the Company had no overdue but not impaired accounts receivable. (4) No actual written-off of accounts receivable in this period. (5) Accounts receivable due from the top five debtors As of 31 December 2022, the total amount of the top five debtors in closing balance is RMB56,820,132.30, accounting for 18.71% of the total amount of closing balance of accounts receivable, and the corresponding closing balance of provision for bad debts is total RMB528,427.24. (6) There were no accounts receivable derecognized due to the transfer of financial assets in each reporting period. (7) There were no assets or liabilities formed by the continuing involvement of transferred accounts receivables in each reporting period. 3. Other receivables Item 2022.12.31 2021.12.31 Dividends receivable 544,999,500.00 814,041,000.00 Other receivables 240,307,524.78 322,196,811.25 Total 785,307,024.78 1,136,237,811.25 (1) Dividends receivable Item 2022.12.31 2021.12.31 Topsino 524,999,500.00 749,999,500.00 Haibin Pharma 0.00 44,041,500.00 Fenglei Electric Power 20,000,000.00 20,000,000.00 Subtotal: 544,999,500.00 814,041,000.00 Less: Provision for bad debts 0.00 0.00 Total 544,999,500.00 814,041,000.00 (2) Other receivables 286 Joincare Pharmaceutical Group Annual Report 2022 ① by ageing Item 2022.12.31 2021.12.31 Within one year 239,838,488.56 321,955,080.06 1 to 2 years 590,397.78 149,812.10 2 to 3 years 149,812.10 206,676.00 3 to 4 years 206,676.00 126,228.36 4 to 5 years 126,228.36 20,000.00 Over 5 years 19,105,586.00 19,085,586.00 Subtotal 260,017,188.80 341,543,382.52 Less: Provision for bad debts 19,709,664.02 19,346,571.27 Total 240,307,524.78 322,196,811.25 ② Disclosure by nature 2022.12.31 2021.12.31 Item Provision for Provision for Carrying Book balance Carrying amount Book balance bad debts bad debts amount Other receivables of each company 238,041,400.41 0.00 238,041,400.41 294,833,504.86 0.00 294,833,504.86 within the scope of combination Capital reduction 0.00 0.00 0.00 24,078,925.22 0.00 24,078,925.22 Treasury bonds and 17,968,386.04 17,968,386.04 0.00 17,968,386.04 17,968,386.04 0.00 security deposits External entities 1,384,240.83 1,253,731.83 130,509.00 3,763,793.73 1,220,062.29 2,543,731.44 balances Security deposits 973,098.11 354,429.35 618,668.76 848,272.56 157,320.34 690,952.22 Others 1,650,063.41 133,116.80 1,516,946.61 50,500.11 802.60 49,697.51 Total 260,017,188.80 19,709,664.02 240,307,524.78 341,543,382.52 19,346,571.27 322,196,811.25 ③Information of provision for bad debts At year end, provision for bad debts on those in first stage: Expected credit loss rate Provision for Carrying Category Book balance Reason in the next 12 bad debts amount months (%) Provision for bad debts on 0.00 0.00 0.00 0.00 individual item Capital reduction 0.00 0.00 0.00 0.00 Provision for bad debts on 238,041,400.41 0.00 0.00 238,041,400.41 portfolio basis Other receivables of each Expected to be company within the scope of 238,041,400.41 0.00 0.00 238,041,400.41 recovered combination Total 238,041,400.41 0.00 0.00 238,041,400.41 At year end, provision for bad debts on those in second stage: Expected credit Provision for Carrying Category Book balance loss rate for the Reason bad debts amount lifetime(%) Provision for bad debts on individual item 287 Joincare Pharmaceutical Group Annual Report 2022 Expected credit Provision for Carrying Category Book balance loss rate for the Reason bad debts amount lifetime(%) Provision for bad debts on portfolio 4,007,402.35 43.45 1,741,277.98 2,266,124.37 basis Security deposits, deposits and rental 973,098.11 36.42 354,429.35 618,668.76 receivable Other receivables 3,034,304.24 45.71 1,386,848.63 1,647,455.61 Total 4,007,402.35 43.45 1,741,277.98 2,266,124.37 At year end, provision for bad debts on those in third stage: Expected credit Provision for Carrying Category Book balance loss rate for the Reason bad debts amount lifetime(%) Provision for bad debts on 17,968,386.04 100.00 17,968,386.04 0.00 individual item Treasury bonds and security 17,968,386.04 100.00 17,968,386.04 0.00 Not expected to deposits be recoverable Provision for bad debts on 0.00 0.00 0.00 0.00 -- portfolio basis Total 17,968,386.04 100.00 17,968,386.04 0.00 As of 31 December 2021, information of provision for bad debts: As of 31 December 2021, Provision for bad debts on those in first stage: Expected credit loss rate Provision for Carrying Category Book balance Reason in the next 12 bad debts amount months (%) Provision for bad debts on 24,078,925.22 0.00 0.00 24,078,925.22 individual item Expected to be Capital reduction 24,078,925.22 0.00 0.00 24,078,925.22 recovered Provision for bad debts on 294,833,504.86 0.00 0.00 294,833,504.86 portfolio basis Other receivables of each Expected to be company within the scope of 294,833,504.86 0.00 0.00 294,833,504.86 recovered combination Total 318,912,430.08 0.00 0.00 318,912,430.08 As of 31 December 2021, provision for bad debts on those in second stage: Expected credit loss Provision for Carrying Category Book balance rate for the Reason bad debts amount lifetime(%) Provision for bad debts on 0.00 0.00 0.00 0.00 individual item Provision for bad debts on 4,662,566.40 29.56 1,378,185.23 3,284,381.17 portfolio basis Security deposits, deposits and 877,102.56 17.99 157,778.54 719,324.02 rental receivable Other receivables 3,785,463.84 32.24 1,220,406.69 2,565,057.15 Total 4,662,566.40 29.56 1,378,185.23 3,284,381.17 As of 31 December 2021, provision for bad debts on those in third stage: Expected credit Provision for Carrying Category Book balance loss rate for the Reason bad debts amount lifetime(%) 288 Joincare Pharmaceutical Group Annual Report 2022 Provision for bad debts on 17,968,386.04 100.00 17,968,386.04 0.00 individual item Treasury bonds and security 17,968,386.04 100.00 17,968,386.04 0.00 Not expected to deposits be recoverable Provision for bad debts on 0.00 0.00 0.00 0.00 -- portfolio basis Total 17,968,386.04 100.00 17,968,386.04 0.00 ④ Accrual, recovery or reversal of bad debt provision during the period First stage Second stage Third stage Expected credit Expected credit Provision for bad debts Expected credit loss for lifetime loss for lifetime Total loss within next 12 (no credit (credit months impairment impairment has occurred) occurred) Beginning balance 0.00 1,378,185.23 17,968,386.04 19,346,571.27 Movement of beginning balance during the period --transfer to second stage 0.00 0.00 0.00 0.00 --transfer to third stage 0.00 0.00 0.00 0.00 --Reverse to second stage 0.00 0.00 0.00 0.00 --Reverse to first stage 0.00 0.00 0.00 0.00 Provision for the year 0.00 363,092.75 0.00 363,092.75 Reversal in the year 0.00 0.00 -158,470.77 -158,470.77 Transfer in the year 0.00 0.00 0.00 0.00 Write-off in the year 0.00 0.00 -158,470.77 -158,470.77 Other movement 0.00 0.00 0.00 0.00 Closing balance 0.00 1,741,277.98 17,968,386.04 19,709,664.02 ⑤ No actual written-off of other receivables in this period ⑥ Other receivables due from the top five debtors Proportion to Closing Closing balance of total other balance of Name of entity Nature Ageing other receivables receivables provision for (%) bad debts Shenzhen Fenglei Electric Other receivables of each company Power Investment Co., Ltd. (深 129,956,104.29 2-3 years 49.98 0.00 within the scope of 圳市风雷电力投资有限公司) combination Joincare Haibin Pharmaceutical Other receivables of each company Within one Co., Ltd. (健康元海滨药业有 45,397,838.87 17.46 0.00 within the scope of year 限公司) combination Hua Xia Securities Co., Ltd. (华 Treasury bonds and Over 5 17,968,386.04 6.91 17,968,386.04 夏证券股份有限公司) security deposits years Joincare (Guangdong) Special Other receivables medicine Food Co., Ltd. (健康 of each company Within 2 15,751,011.27 6.06 0.00 within the scope of years 元(广东) 特医食品有限公司) combination Other receivables Topsino Industries Limited (天 of each company 15,736,384.51 2-3 years 6.05 0.00 诚实业有限公司) within the scope of combination 289 Joincare Pharmaceutical Group Annual Report 2022 Proportion to Closing Closing balance of total other balance of Name of entity Nature Ageing other receivables receivables provision for (%) bad debts Total 224,809,724.98 86.46 17,968,386.04 ⑦ There were no other receivables derecognised due to the transfer of financial assets in each reporting period. ⑧ There were no assets or liabilities formed by the continuing involvement of transferred other receivables in the period. 4. Long-term equity investment 2022.12.31 2021.12.31 Item Provision for Provision for Book balance Carrying amount Book balance Carrying amount impairment impairment Investment in 3,453,138,312.11 7,010,047.91 3,446,128,264.20 3,453,138,312.11 7,010,047.91 3,446,128,264.20 subsidiaries Investment 78,056,248.43 0.00 78,056,248.43 84,810,888.09 0.00 84,810,888.09 in associates Total 3,531,194,560.54 7,010,047.91 3,524,184,512.63 3,537,949,200.20 7,010,047.91 3,530,939,152.29 (1) Investment in subsidiaries Provision Closing for balance of Investee 2021.12.31 Increase Decrease 2022.12.31 impairment provision for in the year impairment Livzon Group 608,741,654.08 0.00 0.00 608,741,654.08 0.00 0.00 Haibin Pharma 783,054,186.38 0.00 0.00 783,054,186.38 0.00 0.00 Joincare Daily- 24,116,498.56 0.00 0.00 24,116,498.56 0.00 1,610,047.91 Use Topsino 813,552,689.31 0.00 0.00 813,552,689.31 0.00 0.00 Taitai Genomics 37,500,000.00 0.00 0.00 37,500,000.00 0.00 0.00 Taitai 105,939,709.72 0.00 0.00 105,939,709.72 0.00 0.00 Pharmaceutical Shenzhen 170,100,000.00 0.00 0.00 170,100,000.00 0.00 5,400,000.00 Hiyeah Fenglei Electric 100,763,433.06 0.00 0.00 100,763,433.06 0.00 0.00 Power Jiaozuo Joincare 375,000,000.00 0.00 0.00 375,000,000.00 0.00 0.00 Shanghai 32,500,000.00 0.00 0.00 32,500,000.00 0.00 0.00 Frontier Taitai Biological 4,832,950.00 0.00 0.00 4,832,950.00 0.00 0.00 Joincare Haibin 100,000,000.00 0.00 0.00 100,000,000.00 0.00 0.00 Joincare Special 3,000,000.00 0.00 0.00 3,000,000.00 0.00 0.00 Food Livzon Biologics 294,037,191.00 0.00 0.00 294,037,191.00 0.00 0.00 Total 3,453,138,312.11 0.00 0.00 3,453,138,312.11 0.00 7,010,047.91 290 Joincare Pharmaceutical Group Annual Report 2022 (2) Investment in associates and joint ventures Movement in the year Closing Investment Adjustment in Announced balance of Investee 2021.12.31 income/loss Changes Provision 2022.12.31 Additions in Decrease in other distribution of provision for recognized of other for Others investment investment comprehensive cash dividend impairment under the equity impairment income or profit equity method Associates Ningbo Ningrong Biomedical Co., Ltd. (宁波宁融生物医药有 27,464,098.71 0.00 0.00 -284,889.20 0.00 0.00 0.00 0.00 0.00 27,179,209.51 0.00 限公司) Feellife Health Inc. (深圳来福 10,689,582.15 0.00 0.00 1,712,742.07 0.00 0.00 0.00 0.00 0.00 12,402,324.22 0.00 士雾化医学有限公司) Novastage Pharmaceuticals (Shenzhen) , Ltd. (新领医药技 18,080,883.21 0.00 18,080,883.21 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 术(深圳) 有限公司) Jiangsu Baining Yingchuang Medical Technology Co., Ltd. 28,576,324.02 0.00 0.00 156,057.09 0.00 0.00 0.00 0.00 0.00 28,732,381.11 0.00 (江苏百宁盈创医疗科技有限 公司) Shanghai Sheo Pharmaceutical Technology Co., Ltd. (上海偕怡 0.00 10,000,000.00 -257,666.41 0.00 0.00 0.00 0.00 0.00 9,742,333.59 医药科技有限公司) Subtotal 84,810,888.09 10,000,000.00 18,080,883.21 1,326,243.55 0.00 0.00 0.00 0.00 0.00 78,056,248.43 0.00 291 Joincare Pharmaceutical Group Annual Report 2022 5. Operating income and operating cost (1) Operating income and operating cost 2022 2021 Item Revenue Cost Revenue Cost Primary 1,997,946,818.28 1,345,944,915.00 2,318,838,433.60 1,570,518,398.66 operations Other 55,049,131.18 42,380,613.14 23,227,007.34 10,880,121.11 operations Total 2,373,887,564.78 1,612,899,011.80 2,021,173,825.62 1,356,825,036.11 (2) Primary Disaggregate information of operating income ① Segregation by products 2022 2021 Item Revenue Cost Revenue Cost Chemical pharmaceuticals 2,156,627,002.13 1,467,215,984.98 1,844,258,573.30 1,249,873,341.86 (化学药物) Traditional Chinese medicine (中药制 42,843,606.38 24,726,803.46 38,481,963.54 22,519,595.22 剂) Health care products (保健食 119,285,823.66 78,384,343.41 115,187,552.33 73,483,571.30 品) Others 82,001.43 191,266.81 18,729.10 68,406.62 Total 2,318,838,433.60 1,570,518,398.66 1,997,946,818.28 1,345,944,915.00 ② Segregation by operating location 2022 2021 Item Revenue Cost Revenue Cost Domestic 2,318,555,876.08 1,570,367,026.33 1,997,946,818.28 1,345,944,915.00 Overseas 282,557.52 151,372.33 0.00 0.00 Total 2,318,838,433.60 1,570,518,398.66 1,997,946,818.28 1,345,944,915.00 ③ Segregation by timing of revenue recognition 2022 2021 Item Revenue Cost Revenue Cost Commodities (Recognized at a 2,318,838,433.60 1,570,518,398.66 1,997,946,818.28 1,345,944,915.00 point in time) a point in time) Total 2,318,838,433.60 1,570,518,398.66 1,997,946,818.28 1,345,944,915.00 (3) Disaggregate information of other operations 2022 2021 Item Revenue Cost Revenue Cost 292 Joincare Pharmaceutical Group Annual Report 2022 Processing fees 4,837,029.47 4,329,387.37 1,403,169.59 1,712,962.53 Rental fees 9,861,266.50 1,445,184.13 13,104,696.50 1,989,089.05 Technical services 27,233,207.55 23,946,403.27 0.00 0.00 Others 13,117,627.66 12,659,638.37 8,719,141.25 7,178,069.53 Total 55,049,131.18 42,380,613.14 23,227,007.34 10,880,121.11 6. Investment income Item 2022 2021 Gain from disposal of long-term equity investment 985,288,053.40 1,351,395,397.50 Investment income from long-term equity investments under equity -2,005,822.14 1,326,243.55 method Investment income from disposal of long-term equity investments 4,242,404.46 -59,868,800.00 Dividend income from other equity instrument investments 512,350.35 4,175,569.86 Investment income from disposal of financial assets held for trading 0.00 50,958.36 Total 991,369,051.76 1,293,747,303.58 XVI. Supplement information 1. Statement of non-recurring profit or loss Item 2022 2021 Gain or loss on disposal of non-current assets -705,357.30 14,492,047.24 Unauthorized approval, or no formal approval documents, or occasional tax 0.00 0.00 refunds, reductions and exemptions Government grants that are included in the profit and loss(except for government grants that are closely related to the company’s normal business 286,842,932.33 245,335,140.69 operations and that meet the national policy requirements and continue to enjoy a certain amount or quantitative basis according to certain standards) Capital occupation fees from non-financial enterprises 0.00 0.00 Gains resulting from the investment cost of the enterprise for the purpose of acquisition of the subsidiaries, joint operation and joint ventures is lower than 0.00 0.00 the fair value of net identifiable assets of the investee as entitled at the time of receipt of the investment Profit or loss from exchange of non-monetary assets 0.00 0.00 Gain or loss from entrusting others to invest or manage assets 0.00 0.00 Provision for impairment of assets accrued due to force majeure factors, such 0.00 0.00 as natural disasters Gain or loss arising from debt restructuring 0.00 0.00 Enterprise restructuring fees, such as the expenses for employees’ settlement 0.00 0.00 and the integration fees Profit or loss exceeding the fair value and generated from the transaction of 0.00 0.00 which the transaction price is obviously unfair Net profit or loss over the current period of the subsidiaries as a result of business combination under common control from the beginning of the year to 0.00 0.00 the date of consolidation Gain or loss arising from contingencies unrelated to the company’s normal 0.00 0.00 operation Except for the efficient hedging related to the Company’s normal business, profit or loss from changes in fair value as generated from financial assets and financial liabilities held for trading and gains from investment as a result of the -109,887,696.11 8,110,644.25 disposal of financial assets and financial liabilities held for trading and debt investments Reversals of provision for impairment of accounts receivable with individual 158,470.77 1,013,650.67 impairment test 293 Joincare Pharmaceutical Group Annual Report 2022 Item 2022 2021 Profit or loss from entrusted loans 0.00 0.00 Gain or loss from fluctuation in fair value of investment property which is 0.00 0.00 measured at fair value Impact of a one-time adjustment on current profit and loss according to the 0.00 0.00 requirements of tax and accounting, laws and regulations Custody fees of entrusted operation 0.00 0.00 Other non-operating income and expenses other than the above -23,830,838.49 -30,737,442.83 Other gain or loss items met the definition of non-recurring item 0.00 0.00 Total amount of non-recurring items 152,577,511.20 238,214,040.02 Less: effects of income tax on non-recurring items 31,919,034.26 39,580,260.30 Less: Non-recurring items attributable to the minority shareholders (after tax) 37,113,548.72 95,131,719.24 Non-recurring items attributable to the shareholders of the Company 83,544,928.22 103,502,060.48 2. Rate of return on net assets and earnings per share For the year ended 31 December 2022 Earnings per share Weighted average Profit in reporting period Basic earnings per Diluted earnings return on equity (%) share per share Net profit attributable to the shareholders of the 12.23 0.7933 0.7921 Company Net profit attributable to ordinary shareholders of the Company after deducting non-recurring 11.55 0.7492 0.7481 gains and losses For the year ended 31 December 2021 Earnings per share Weighted average Profit in reporting period return on equity (%) Basic earnings per Diluted earnings share per share Net profit attributable to the shareholders of the 11.50 0.6864 0.6858 Company Net profit attributable to ordinary shareholders of the Company after deducting non-recurring 10.60 0.6329 0.6324 gains and losses Joincare Pharmaceutical Group Industry Co., Ltd. 7 April 2023 294