SHANGHAI JUNSHI BIOSCIENCES CO., LTD.*


                                          1877




                 2020       8    19

                                                   50%   50%




14.04(9)        5%          25%
                                          14

                 2020   8       19

                                                 50%   50%




                                      1
2020   8    19

(1)

(2)




                        200,000,000




                     100,000,000
           50%




                 2
                       IMP4297
100,000,000                           50%


IMP4297

                  IMP4297
100,000,000
  IMP4297                      300,000,000


50%   50%




                     200,000,000




                                   I M P4297

                   CMC
       CMO




(i)




              3
(ii)

        IMP4297

(iii)


                         2021   12   31




                                      IMP4297
                            IMP4297
                   IMP4297
                    IMP4297




                   II III
                  IMP4297




           IMP4297




                     4
                     IMP4297

IMP4297


           IMP4297




 IMP4297
    5




             5
                                               PARP




                                                           30




                     DNA                 DDR




   IMP4297

IMP4297 Senaparib                             -ADP          PARP
                                         Senaparib     I
2019 ASCO             I             Senaparib
                    PARP                              Senaparib
     II                   BRCA
                      Senaparib
             III




                                         H
   1877)    A                     688180)




                            6
                                               PARP

                                   IMP4297




    14.04(9)   5%   25%
                              14




A                                   1.00




                                       IMP4297




                                   A       H




                          7
H                1.00




IMP4297
                     IMP4297




IMP4297
                               PARP




              2020   8   19




                 IMP4297




          8
                                                1.00
                              H   A




                                      IMP4297




    %




              2020   8   20




        Roy Steven Herbst

*




                              9