年報 2022 2 4 5 7 25 50 71 113 121 128 130 132 134 137 242 246 2 15 20 2010 1 2206-19 979 27 3 2022 1386 23 5 33 19 1901 506 H 183 17 1712-1716 320 A (86) 021-52293555 (86) 021-52293558 www.3healthcare.com 166 H 6826 H 36,330,000 H H 1.00 688366 A 137,800,000 A A 1.00 4 2,103,438 1,750,116 1,324,427 1,595,498 1,545,824 1,446,923 1,259,746 990,423 1,231,499 1,211,538 235,726 382,649 257,026 434,349 525,185 180,470 352,234 230,072 370,779 414,540 68.8% 72.0% 74.8% 77.2% 78.4% 9.0% 19.8% 17.1% 23.2% 26.8% 1 1.04 2.00 1.30 2.27 2.59 6,892,399 6,950,356 6,298,705 6,151,871 4,436,352 990,016 890,070 564,460 498,518 600,905 5,514,609 5,713,461 5,490,751 5,454,780 3,611,511 14.4% 12.8% 9.0% 8.1% 13.5% 1 5 2022 2,103.44 180.47 158.75 Contamac myOK Hiline OK 6 100 100 100 100 7 2022 Bioxis 2,103.44 353.32 20.19% (%) (%) (%) 765,969 36.42 670,969 38.34 14.16 744,342 35.39 460,985 26.34 61.47 386,477 18.37 400,001 22.86 -3.38 176,272 8.38 191,928 10.97 -8.16 30,378 1.44 26,233 1.49 15.80 2,103,438 100.00 1,750,116 100.00 20.19 68.79% 71.98% 1) 2.49% 2) 1.42% 8 182.19 14.59 8.71% 8.66% 9.58% 180.47 158.75 48.76% 51.60% 1 37.35 2 Aaren Scientific, Inc. Aaren Aaren Aaren 18.82 Aaren Aaren 46.07 3 30.23 4 1 56.22 6,892.39 5,514.61 9 2022 50.83% 45.24% Contamac Holdings 70 765.97 95.00 14.16% (%) (%) (%) 366,000 47.78 437,820 65.25 -16.40 277,149 36.18 330,968 49.33 -16.26 88,851 11.60 106,852 15.92 -16.85 377,006 49.22 216,239 32.23 74.35 179,460 23.43 161,336 24.05 11.23 197,546 25.79 54,903 8.18 259.81 22,963 3.00 16,910 2.52 35.80 765,969 100.00 670,969 100.00 14.16 10 366.00 71.82 16.40% 277.15 16.26% Aaren Aaren 4.87 36.86 Lenstec 88.85 16.85% 377.01 160.77 74.35% 179.46 18.12 11.23% Contamac Holdings 197.55 142.64 22.96 11 2022 Contamac Holdings Aaren 1 2 3 3+11 32.5% 44.2% 14 6 12 Contamac myOK Hiline RGP 40 myOK DK 141 7 Hiline PRL -10.00D~-30.00D PRL 1,800 PRL 13 2022 hEGF 2021 2020 23.84% 25.95% 14 744.34 283.36 61.47% (%) (%) (%) 306,164 41.13 239,351 51.93 27.91 149,816 20.13 127,249 27.60 17.73 288,362 38.74 94,385 20.47 205.52 744,342 100.00 460,985 100.00 61.47 1,436 3.6% 15% 2,300 306.16 66.81 27.91% Bioxis 30% 15 2022 hEGF 149.82 22.57 17.73% hEGF 288.36 EndyMed Ltd. 94.39 386.48 3.38% (%) (%) (%) 258,435 66.87 263,502 65.88 -1.92 128,042 33.13 136,499 34.12 -6.20 386,477 100.00 400,001 100.00 -3.38 65 58% 65%-67% 75 80% 1 2ml 2.5ml 3ml 16 43.30% 45.49% 28.85% 176.27 15.66 8.16% (%) (%) (%) 73,203 41.53 94,222 49.09 -22.31 82,613 46.87 76,272 39.74 8.31 20,456 11.60 21,434 11.17 -4.56 176,272 100.00 191,928 100.00 -8.16 17 2022 myOK Hiline 18 2,103.44 1,750.12 353.32 20.19% 123.97 236.18 68.79% 71.98% 147.85 198.43 50.58 25.49% 1 56.22 679.53 612.34 67.19 10.97% 44.84 8.34 5.77 19 2022 405.30 286.09 119.21 41.67% 1 50.79 2 16.18 3 23.17 4 9.87 182.19 167.60 14.59 8.71% 8.66% 9.58% 72.41 9.91 62.50 630.68% 1 Aaren Aaren Aaren Aaren 46.07 2 8.17 3 7.78 100 Recros Medica 6.38 Bioxis 1.40 20 45.40 35.37 19.26% 10.02 25% 180.47 352.23 171.76 48.76% (1) 37.35 2 30.23 3 54.24 7.78 4 1 1 56.22 1.04 2.00 3,532.12 180.47 4.86% H 511.28 24.01 4.93% 6.91 7.62 21 2022 1,990 701 344 599 86 260 1,990 533.22 414.38 118.84 1 96.36 (2) A A H 1,800,000 22 0.61 1.84 0.62 65.00 990.02 14.36% 12.81% 1.55 75.94 41.75 34.44 559.20 1,283.89 724.69 681.82 288.35 231.30 23 2022 Bioxis 41.75 5.31 0.72 5.35 Bioxis 25.18 0.68 4.91 47 24 A H H 1,692,100 H 89,803,495 H 174,130,000 A H H 2,859,000 H 83,897,235 H 171,271,000 25 2022 5 7 24 63 65 46 23 47 4 71 17 128 241 7 24 26 0.40 68,508,400 I. A [2015]101 1 1 1 1 1 1 50% 20% 1 1 5 A QFII QFII 2009[47] 10% QFII 27 2022 [2014]81 A 10% 10% II. H 10% 10% H [2011]348 H 10% 10% 28 [2014]81 H H 20% H H 12 [2016]127 H H 20% H H 12 29 2022 (1) (2) (3) (4) (5) (6) (7) 1. 2. 3. (1) (2) 4. (1) 80% (2) 40% (3) 20% 5. (1) (2) (3) 30 4 137 138 A [2019] 1793 89.23 17,800,000 A 1,588.294 1,529.268758 I. II. A 31 A 2022 152,926.88 20,863.79 – 88,254.50 – (%) (1) (2) (3) (2)-(1) (4) (2)/(1) 1 2 – 128,413.00 128,413.00 128,413.00 20,863.79 63,369.15 -65,043.85 49.35 – 3 – 20,000.00 20,000.00 20,000.00 – 20,135.79 135.79 100.68 – 148,413.00 148,413.00 148,413.00 20,863.79 83,504.94 -64,908.06 56.27 – – – – 4 – 1,300.00 – – – – – – – – 4,552.22 4,552.22 – 4,749.56 197.34 104.34 – – 1,300.00 4,552.22 4,552.22 – 4,749.56 197.34 104.34 – – – – – 149,713.00 152,965.22 152,965.22 20,863.79 88,254.50 -64,710.72 57.70 – – – – 32 208 208 208 208 208 208 208 208 33 2022 98,000 12 87,000 12 770,000,000.00 1 2 3 20,135.79 20,000.00 135.79 4 4,749.56 4,552.22 197.34 34 A 137,800,000 79.136% H 36,330,000 20.864% H (1) 1,601,700 56.00 49.70 85,262,530.00 2,819,900 30.90 27.30 82,839,215.00 39,100 28.40 26.55 1,058,020.00 4,460,700 169,159,765.00 (1) 53.21% 19.08% 35 2022 9.94% 3.72% 5% 13 904,838,000 29 36 3.13 13.51B(1) 37 2022 38 (a) (b) (c) (d) 8 9 39 2022 500,000 1,000,000 3 1,000,001 1,500,000 1 1,990 6 6 40 352 XV 7 8 XV H A H A (1) (%) (%) (%) 5,982,000 (L) 50,000(L) 4.38 3.46 6,000,000 (L) 70,000(L) 4.40 3.49 400,000 (L) 50,000(L) 0.33 0.26 7,000 (L) 0.02 50,000(L) 0.04 0.03 (2) 28,800,000 (L) 20.90 16.54 50,920,000 (L) 36.95 29.24 2,000,000 (L) 1.45 1.15 2,000,000 (L) 1.45 1.15 (3) 2,000(L) 0.001 0.001 L 1. A 1,800,000 2. 28,800,000 A 44,449,000 A 6,471,000 A 3. A 2,000 2,000 352 XV 7 8 41 2022 XV 2 3 336 A A A (%) (%) (1) 44,449,000 (L) 32.26 25.53 28,800,000 (L) 20.90 16.54 6,471,000 (L) 4.70 3.72 (2) 6,471,000 (L) 4.70 3.72 6,471,000 (L) 4.70 3.72 (2) 7,125,075 (L) 5.17 4.09 L 1. 44,449,000 A 28,800,000 A 6,471,000 A 2. 42 H H H (%) (%) Morgan Stanley (1) 2,220,542(L) 6.11 1.28 826 (S) 0.002 0.0005 Prudence Investment 1,969,600(L) 5.42 1.13 Management (Hong Kong) Limited L S 1. Morgan Stanley 2,220,542 H 826 H Morgan Stanley Morgan Stanley & Co. International plc Morgan Stanley & Co. LLC 2,220,542 H 826 H 2. (www.hkexnews.com.hk) XV 2 3 336 43 2022 A A A H I. II. A III. 1,800,000 1.05% IV. 5% 1.00% V. 95.00 94.30 44 VI. 36 22.5 30.5 12 12 50% 24 24 50% 36 12 50% 24 24 50% 36 45 2022 VII. A 50,000 0 50,000 92.25 0 70,000 0 70,000 92.25 0 50,000 0 50,000 92.25 0 50,000 0 50,000 92.25 0 2,000 0 2,000 92.25 0 94.3 20.33 26.96 46 A 25% I. 49% 51% 14A 14.07 0.1% 5% 14A 3,790,325 9,500,000 (1) (2) (3) 47 2022 (1) (2) (3) 3000 740 14A.56 II. A A A H A A 95.00 Robert John McGregor David Simon Wyatt Mak Cheung Kwai Anthony Robert Edward Lewis 14A 345,000 95.00 94.30 A 14A . A 48 14A 14A 42 42(b) 14A.76 14A 14A 14A 42 14A 131,500 49 2022 13.20 13.21 13.22 50 51 2022 (1) (1) (1) 3.10(1) (2) 3.13 3.13 113 117 52 1/2 12/12 12/12 12/12 12/12 12/12 12/12 (1) 6/6 (1) 6/6 12/12 12/12 12/12 12/12 (1) 53 2022 C.1.4 C.2.1 54 I. 55 2022 II. 56 113 117 12 61及以上 10 8 51-60 6 4 2 41-50 0 4 2 1,990 1,052 938 57 2022 (1) (2) (3) (4) (5) ESG 3.10(2) 58 ESG 6/6 (1) 2/2 (1) 4/4 6/6 6/6 6/6 (1) E.1.2(c) 59 2022 1/1 1/1 (1) 1/1 (1) 0/0 1/1 1/1 (1) 60 3/3 3/3 (1) 2/2 (1) 1/1 3/3 3/3 (1) 61 2022 H A H A 2/2 2/2 2/2 2/2 2/2 A A 62 2.78 0.15 121 127 63 2022 D.2 64 I. II. 65 2022 III. IV. H 4,551,100 H 66 Vistra Corporate Services (HK) Limited 3.29 I. 10% 1. 10% 10 2. 5 3. 10 67 2022 4. 5 5. 90 10% 10% 6. II. III. 3% 68 3% (10) (2) IV. 1386 24 1386 A 24 1386 H 24 1386 24 1386 A 24 1386 H 24 69 2022 (1) 3/6 6/6 6/6 6/6 6/6 6/6 (2) 3/3 (2) 3/3 6/6 6/6 6/6 6/6 (1) A H (2) 70 e 71 2022 ESG ESG ESG ESG ESG 72 ( www.hkexnews.hk) ( www.sse.com.cn) ( www.3healthcare.com) 2022 73 2022 2022 100 100 100 100 A ESG AA 30 2022 GMP PH FDA(510)K 74 1.1 75 2022 8 76 IT T3+ 77 2022 1.2 ESG -ESG ESG ESG ESG ESG ESG ESG ESG ESG ESG ESG ESG ESG ESG ESG ESG ESG 78 ESG ESG ESG 79 2022 ESG 27 16 5.8 5.7 5.6 5.5 5.4 5.3 5.2 5.2 5.3 5.4 5.5 5.6 5.7 5.8 80 2.1 182.19 8.71% 8.66% 8 81 2022 344 17.29% 24 78 67 37 348 100 82 R3 83 2022 84 2.2 GMP GMP 85 2022 341 281 60 86 87 2022 2.3 1 CRM CRM CRM CRM 88 3.1 EHS ISO 14001 3.2 TCFD 89 2022 90 91 2022 ESG 92 3.3 93 2022 94 95 2022 274,515 320,552 229,074 5 1.56 2.30 2.07 668.08 564.58 474.25 5 3.80 4.04 4.28 26.07 26.52 19.77 40.21 62.42 111.90 0 0 2.90 11,163.60 9,872.26 10,589.63 1,848,339 2,014,772 1,555,197 1 6,824.17 6,836.81 5,748.83 3 38.81 48.92 51.90 2 3 4,119 4,546 3,712 4 18,174 21,314 16,939 22,293 25,860 20,651 5 0.13 0.19 0.19 1 (GBT2589-2020) 2 3 4 2022 [2021]111 5 96 3.4 VOCs VOCs VOCs VOCs VOCs 97 2022 100% 98 238.08 317.05 25.42 (SO2) 0.07 0.32 0.05 (NOx) 0.88 1.28 0.94 (VOCs) 0.53 0.71 0.22 0.19 0.20 0.17 (COD) 5.99 8.46 15.31 0.07 0.29 0.15 379.67 356.144 305.60 3 2.16 2.55 4 2.76 1 37.27 20.86 11.41 2 81.38 71.99 95.77 261.02 263.29 198.42 59.88 59.21 55.92 3 0.34 0.42 0.50 1 2 3 4 99 2022 1,990 213 287 386 11% 15% 19% 938 1,052 47% 53% 1,777 1,317 89% 66% 100 4.1 A 204 144.00 93 36.00 285 14.32% 101 2022 14.64% 14.64% 14.64% 13.97% 13.97% 13.97% 5.23% 50 50 5.23% 5.23% 11.47% 30~49 11.47% 11.47% 30.83% 30 30 30.83% 30.83% 15.76% 15.76% 15.76% 2.35% 2.35% 2.35% 102 1,525 20,951 13.74 240 16% 761 764 50% 50% 1,285 84% 13.86 13.11 16.29 11.19 103 2022 4.2 104 ISO 45001 0 0 105 2022 106 131,500 107 2022 ESG (KPI) A1 (a) (b) A1.1 A1.2 A1.3 A1.4 A1.5 A1.6 108 (KPI) A2 A2.1 A2.2 A2.3 A2.4 A2.5 A3 A3.1 A4 A4.1 109 2022 (KPI) B1 B1.1 B1.2 B2 B2.1 B2.2 B2.3 110 (KPI) B3 B3.1 B3.2 B4 B4.1 B4.2 B5 B5.1 B5.2 B5.3 B5.4 111 2022 (KPI) B6 B6.1 B6.2 B6.3 B6.4 B6.5 B7: B7.1 B7.2 B7.3 112 (KPI) B8: B8.1 B8.2 113 2022 61 RNA 114 59 Haohai Healthcare Holdings (Cayman) Co., Ltd. Haohai Healthcare Holdings (BVI) Co., Ltd. Contamac Holdings Haohai Aesthetic Holdings (BVI) Co., Ltd. 41 115 2022 47 Contamac Holdings 60 47 Contamac Holdings China Ocean Group Limted 116 46 603617 000096 601156 600009 48 300363 600874 1065 000671 600021 000863 600816 601336 1336 54 117 2022 45 6199 872632 601328 3328 300597 59 49 600712 000166 6806 118 54 51 (University of Illinois at Urbana-Champaign) Freeman Fellows 44 MBA EMBA 43 119 2022 39 41 65 56 49 120 33 33 45 Vistra Corporate Services (HK) Limited Vistra Corporate Services (HK) Limited TMF Hong Kong Limited 121 2022 Ernst & Young Tel : +852 2846 9888 27/F, One Taikoo Place 979 Fax : +852 2868 4432 979 King’s Road 27 ey.com Quarry Bay, Hong Kong 128 241 122 2,103 2.4 5 123 2022 4.11 0.97 2.4 3 15 16 124 51.00% 70 14 102 2.4 38 125 2022 126 127 2022 128 5 2,103,438 1,750,116 (656,515) (490,370) 1,446,923 1,259,746 5 147,852 198,429 (679,532) (612,341) (405,304) (286,093) (15,516) 3,182 (182,192) (167,597) (72,407) (9,907) 7 (7,603) (4,963) 3,204 2,100 301 93 6 235,726 382,649 10 (45,395) (35,366) 190,331 347,283 18,401 (16,824) 18,401 (16,824) 129 2022 2022 2021 (112,896) 124,199 4,865 (10,309) (108,031) 113,890 (108,031) 113,890 (89,630) 97,066 100,701 444,349 180,470 352,234 9,861 (4,951) 190,331 347,283 86,778 452,424 13,923 (8,075) 100,701 444,349 12 RMB1.04 RMB2.00 130 13 1,286,396 1,197,037 14 222,441 214,800 15 620,416 613,397 16 411,199 406,901 17 – 47,964 18 3,028 3,448 19 668,412 573,935 30 59,323 49,356 20 89,068 130,932 3,360,283 3,237,770 21 485,239 354,765 22 388,275 375,206 23 104,851 74,837 24 – 6,376 25 9,159 – 26 2,877 614 26 2,541,715 2,900,788 3,532,116 3,712,586 27 54,533 46,264 28 397,710 397,329 29 34,378 42,421 24,654 1,258 511,275 487,272 3,020,841 3,225,314 6,381,124 6,463,084 131 2022 29 83,880 39,493 28 4,500 8,110 30 163,508 157,910 31 5,500 9,402 32 793 1,765 33 220,560 186,118 478,741 402,798 5,902,383 6,060,286 34 174,130 175,822 34 (74,042) – 36 5,414,521 5,537,639 5,514,609 5,713,461 387,774 346,825 5,902,383 6,060,286 132 * * * * * * 175,822 – 3,091,122 61,243 88,923 (13,110) (264) 2,309,725 5,713,461 346,825 6,060,286 – – – – – – – 180,470 180,470 9,861 190,331 – – – (108,031) – – – – (108,031) – (108,031) – – – – – 14,339 – – 14,339 4,062 18,401 – – – (108,031) – 14,339 – 180,470 86,778 13,923 100,701 H – (147,672) – – – – – – (147,672) – (147,672) H (1,692) 73,630 (71,938) – – – – – – – – 38 – – – – – – – – – 54,130 54,130 – – – – – – – – – (12,000) (12,000) – – – – – – – (121,891) (121,891) – (121,891) – – – – – – – – – 761 761 – – (10,720) – – – – – (10,720) 10,720 – – – (29,439) – – – – – (29,439) (5,003) (34,442) – – 26,725 – – – – – 26,725 3,504 30,229 – – (2,633) – – – – – (2,633) 2,707 74 39 – – – – – – – – – (27,793) (27,793) – – – (1,197) – – – 1,197 – – – 174,130 (74,042) 3,003,117 (47,985) 88,923 1,229 (264) 2,369,501 5,514,609 387,774 5,902,383 133 2022 * * * * * * 177,207 (28,263) 3,259,803 35,606 88,923 590 (264) 1,957,149 5,490,751 243,494 5,734,245 – – – – – – – 352,234 352,234 (4,951) 347,283 – – – 113,890 – – – – 113,890 – 113,890 – – – – – (13,700) – – (13,700) (3,124) (16,824) – – – 113,890 – (13,700) – 352,234 452,424 (8,075) 444,349 H – (44,908) – – – – – – (44,908) – (44,908) H (1,385) 73,171 (71,786) – – – – – – – – 38 – – – – – – – – – 264,570 264,570 – – – – – – – – – (15,000) (15,000) – – – – – – – (87,911) (87,911) – (87,911) – – – – – – – – – 5,000 5,000 – – (20,836) – – – – – (20,836) (33,106) (53,942) – – (76,059) – – – – – (76,059) (110,058) (186,117) – – – (88,253) – – – 88,253 – – – 175,822 – 3,091,122 61,243 88,923 (13,110) (264) 2,309,725 5,713,461 346,825 6,060,286 * 5,414,521,000 5,537,639,000 134 235,726 382,649 7 7,603 4,963 17 (3,204) (2,100) 18 (301) (93) 39 90 – 5 (86,446) (96,318) (278) (548) 7,784 (24) 5 (678) (57,538) 5 (1,437) (1,892) 6 417 373 6 112,111 91,800 6 22,262 24,819 6 69,844 46,218 15,516 (3,182) 6 9,574 – 6 6,936 – 6 29,561 – 6 8,168 (687) 31 (7,652) (3,742) 2,684 3,875 6 30,229 – 458,509 388,573 (138,859) (28,627) (52,330) (41,923) 7,454 7,248 (2,263) 349 (1,005) (296) 35,442 32,347 (33,357) 54,830 1,426 – 275,017 412,501 (43,721) (70,215) 231,296 342,286 135 2022 5 86,446 96,318 1,718 547 (309,207) (270,881) (6,335) – (1,606) (1,216) 390 213 9,068 283,292 – 318,165 (2,936) (48,276) 51,168 – (163,162) (387,293) – (309,318) – (35,000) (365,623) 147,821 39 17,586 – 5 678 57,538 (681,815) (148,090) (21,788) (23,962) (10,800) (15,000) 65,943 38,010 (47,911) (95,538) H (147,672) (44,908) – 50,000 – (53,942) 761 5,000 (4,992) (3,000) 11 (121,891) (87,911) (288,350) (231,251) 136 (738,869) (37,055) 1,283,893 1,327,887 14,173 (6,939) 26 559,197 1,283,893 26 2,544,592 2,901,402 26 (1,982,518) (1,616,895) 562,074 1,284,507 26 2,456 614 26 421 – 559,197 1,283,893 137 2022 1. 5 40,000,000 H 45,300 H H 17,800,000 A A A A 177,845,300 40,045,300 H 137,800,000 A 1,692,100 H 2,859,000 H % % 100 – 160,000,000 100 – 150,000,000 138 1. % % – 100 9,923,200 – 60 11,000,000 Contamac Limited 1,000 – 79 62.80 – 126,500,000 EndyMed Ltd. 2,749,248 – 30.76 * * 139 2022 2.1 (a) (b) (c) 140 2.1 (i) (ii) (iii) (i) (ii) (iii) 2.2 3 16 37 1 9 16 41 141 2022 2.2 (a) 3 3 37 21 3 37 21 (b) 16 2 (c) 37 37 142 2.2 (d) 1 9 16 41 9 2.3 10 3 28 16 2 17 1 17 1 5 17 17 9 6 1 2 4 1 2 1 1 2 8 1 12 1 2 3 4 5 17 4 39 9 6 17 143 2022 2.3 10 28 10 28 10 28 16 16 1 12 12 144 2.3 1 2 1 2 8 12 12 145 2022 2.4 20% 5 146 2.4 147 2022 2.4 148 2.4 149 2022 2.4 (a) (i) (ii) (iii) (b) (i) (ii) (iii) (iv) (v) (vi) (a) 150 2.4 (b) (vii) (a)(i) (viii) 2.4% 5.0% 9.0% 33.3% 9.5% 33.3% 9.5% 33.3% 10.0% 20.0% 151 2022 2.4 152 2.4 5 15 36 120 3 15 10 153 2022 2.4 PMMA Contamac Holdings limited Contamac Holdings Contamac Bioxis Pharmaceuticals Bioxis Bioxis 10 154 2.4 (a) 2 10 15 50 (b) 155 2022 2.4 (c) 12 15 156 2.4 32 157 2022 2.4 (a) (b) 158 2.4 12 12 30 159 2022 2.4 12 160 2.4 9 161 2022 2.4 162 2.4 163 2022 2.4 (a) (b) 164 2.4 15 165 2022 2.4 35 166 2.4 167 2022 2.4 11 168 2.4 169 2022 3. 170 3. 171 2022 3. 420,773,000 406,901,000 101,988,000 100,652,000 16 15 620,269,000 506,042,000 19 172 3. 4. (a) 1,699,078 1,542,592 140,814 66,965 103,717 82,918 159,829 57,641 2,103,438 1,750,116 173 2022 4. (b) 2,152,373 2,079,074 256,350 260,989 33,587 81,608 190,238 192,808 2,632,548 2,614,479 10% 5. 2,103,438 1,750,116 174 5. (a) 765,969 670,969 744,342 460,985 386,477 400,001 176,272 191,928 30,378 26,233 2,103,438 1,750,116 2,096,764 1,746,329 6,674 3,787 2,103,438 1,750,116 (b) 175 2022 5. 86,446 96,318 40,276 33,880 678 57,538 1,437 1,892 185 – 18,830 8,801 147,852 198,429 176 6. 656,515 490,370 13 112,111 91,800 22,262 24,819 15 69,844 46,218 2,780 2,980 182,192 167,597 14 4,562 3,746 8 495,058 386,222 38,157 28,153 30,229 – 2,684 3,875 14,795 (2,302) 721 (880) 6,936 – 29,561 – 9,574 – 8,168 (687) (86,446) (96,318) (1,437) (1,892) 90 – 417 373 7. 5,288 3,385 2,315 1,578 7,603 4,963 177 2022 8. 383(1)(a) (b) (c) (f) 1,023 672 4,257 4,003 2,787 1,921 368 341 7,412 6,265 8,435 6,937 (a) * * 63 84 * 63 – * 126 84 * 126 84 * 126 84 * 141 84 645 420 * 178 8. (a) (b) – 795 800 63 1,658 – 855 800 63 1,718 – 795 477 63 1,335 – 675 396 63 1,134 – – – – – 126 – – – 126 – – – – – 126 – – – 126 126 – – – 126 – 741 181 63 985 – 177 – 29 206 – 219 133 24 376 378 4,257 2,787 368 7,790 179 2022 8. (b) – 785 494 57 1,336 – 845 565 57 1,467 – 795 370 57 1,222 – 665 370 57 1,092 – – – – – 84 – – – 84 – – – – – – 561 122 57 740 84 – – – 84 84 – – – 84 – 352 – 56 408 252 4,003 1,921 341 6,517 1 180 9. 8 615 605 800 273 63 57 1,478 935 0-1,000,000 – – 1,000,001-1,500,000 2 3 1,500,001-2,000,000 3 2 5 5 10. 15% 15% 15% 181 2022 10. 25% 25% 16.5% 16.5% 2,000,000 8.25% 8.25% 16.5% 16.5% 21% 21% 19% 19% 25% 28% 23% 23% 66,521 50,719 596 (326) 30 (21,722) (15,027) 45,395 35,366 182 10. % % 235,726 382,649 57,654 24.4 92,470 24.1 596 0.3 (326) (0.1) (57) – (18) – (32,201) (13.7) (32,657) (8.5) 5,913 2.5 3,733 1.0 38,107 16.2 10,579 2.8 (1,126) (0.5) (1,751) (0.5) (4,296) (1.8) (10,135) (2.6) 2,729 1.2 (2,145) (0.6) (233) (0.1) – – (21,691) (9.2) (24,384) (6.4) 45,395 19.3 35,366 9.2 19.3% 9.2% 11. 0.40 68,508 – 0.70 – 123,075 68,508 123,075 183 2022 11. 0.40 68,508,400 0.70 123,075,000 12. 173,562,775 176,125,208 180,470 352,234 173,562,775 176,125,208 184 13. 359,382 646,336 22,973 81,548 369,565 139,825 1,619,629 (67,643) (228,514) (13,221) (45,973) – (67,241) (422,592) 291,739 417,822 9,752 35,575 369,565 72,584 1,197,037 291,739 417,822 9,752 35,575 369,565 72,584 1,197,037 3,376 9,613 – 4,687 218,517 7,067 243,260 38 – 110 824 324 – – 1,258 – (462) (105) (240) – – (807) 39 (13,904) (7,362) (38) (1,046) (12,029) – (34,379) (17,002) (63,795) (3,885) (9,284) – (18,145) (112,111) * – (5,456) (13) (153) (1,242) (72) (6,936) – 48,458 3,919 2,266 (55,898) 1,255 – (1,217) 346 (169) 50 68 (4) (926) 262,992 399,274 10,285 32,179 518,981 62,685 1,286,396 346,247 695,972 27,401 84,410 520,223 110,034 1,784,287 (83,255) (296,698) (17,116) (52,231) (1,242) (47,349) (497,891) 262,992 399,274 10,285 32,179 518,981 62,685 1,286,396 185 2022 13. * * 273,191 437,219 14,210 65,896 441,012 88,478 1,320,006 (53,782) (178,862) (11,452) (38,940) – (58,953) (341,989) 219,409 258,357 2,758 26,956 441,012 29,525 978,017 219,409 258,357 2,758 26,956 441,012 29,525 978,017 – 11,847 8,787 2,936 237,284 8,940 269,794 13,935 12,447 424 2,024 14,464 1,799 45,093 – (403) (158) (25) – – (586) (14,436) (52,389) (2,053) (8,069) – (14,853) (91,800) 74,921 189,170 – 11,880 (323,195) 47,224 – (2,090) (1,207) (6) (127) – (51) (3,481) 291,739 417,822 9,752 35,575 369,565 72,584 1,197,037 359,382 646,336 22,973 81,548 369,565 139,825 1,619,629 (67,643) (228,514) (13,221) (45,973) – (67,241) (422,592) 291,739 417,822 9,752 35,575 369,565 72,584 1,197,037 16 186 14. 15 50 2 10 (a) 174,555 27,823 202,378 – 22,582 22,582 4,083 17,595 21,678 – (504) (504) (8,891) (22,443) (31,334) 169,747 45,053 214,800 6,335 31,983 38,318 38 – 2,470 2,470 – 465 465 – (847) (847) 39 (3,987) – (3,987) (8,979) (19,799) (28,778) 163,116 59,325 222,441 187 2022 14. (b) 46,715 28,657 31,983 22,582 2,315 1,578 38 2,126 18,354 755 (494) (847) – (21,788) (23,962) 61,259 46,715 21,359 17,107 39,900 29,608 46 (c) 2,315 1,578 28,778 31,334 4,562 3,746 35,655 36,658 188 15. * 510 278,922 6,358 182,921 109,835 34,851 613,397 – – 1,606 – – – 1,606 (289) (24,085) (3,332) (28,980) (950) (12,208) (69,844) 38 – – – 27,000 – 75,050 102,050 – (23,630) (659) – (5,272) – (29,561) 39 (95) – – – – – (95) (6) 1,465 68 – 1,336 – 2,863 120 232,672 4,041 180,941 104,949 97,693 620,416 12,381 339,470 15,304 304,961 111,488 112,480 896,084 (12,261) (106,798) (11,263) (124,020) (6,539) (14,787) (275,668) 120 232,672 4,041 180,941 104,949 97,693 620,416 16 189 2022 15. * 723 144,410 7,737 147,803 103,659 – 404,332 – – 1,216 – – – 1,216 (302) (17,688) (2,890) (22,442) (317) (2,579) (46,218) 106 157,816 475 57,560 9,500 37,430 262,887 (17) (5,616) (180) – (3,007) – (8,820) 510 278,922 6,358 182,921 109,835 34,851 613,397 12,507 337,648 13,664 277,961 110,152 37,430 789,362 (11,997) (58,726) (7,306) (95,040) (317) (2,579) (175,965) 510 278,922 6,358 182,921 109,835 34,851 613,397 * PMMA 30,374,000 32,632,000 Contamac 66,342,000 68,020,000 5,272,000 12.5% 12% 2.2% 2% Contamac 12% 12% Contamac 2.2% 2% 190 15. 16. 406,901 385,490 38 13,660 22,415 (9,574) – 212 (1,004) 411,199 406,901 191 2022 16. Contamac 1 2 3 Bioxis 3 4 1 2 55.00% 3 63.64% Bioxis 65.61% 4 51.00% 16% 12% 2.3% 2.3% 14% 12% 2.2% 2% 192 16. 46,071,000 9,574,000 6,936,000 29,561,000 Contamac Contamac 13% 12% 2% 2% 14% 14% 2.3% 2.3% 16% 16% 2.3% 2.3% 21% 21% 2.3% 2.3% 193 2022 16. Bioxis Bioxis 23% 17% 2% 2% 27% 2.3% 266,026 266,026 53,349 53,349 32,115 32,115 Contamac 23,634 24,232 Bioxis 19,730 19,730 13,660 – 2,685 2,685 – 8,764 411,199 406,901 194 16. 195 2022 17. – 47,964 47,964,000 51,168,000 5,304,000 45,864,000 12 31 12 31 3,204,000 2,100,000 3,204 2,100 3,204 2,100 – 47,964 196 18. 2,783 2,549 245 899 3,028 3,448 22 Lifeline Medical Devices Private Limited Lifeline 301 93 301 93 3,028 3,448 197 2022 19. 38,885 50,286 7,012 12,060 2,246 5,547 48,143 67,893 1 268,156 290,329 Eirion Therapeutics, Inc. 167,150 – 76,129 80,000 52,800 12,000 ArcScan, Inc. 39,218 46,347 Ornovi, Inc. 6,965 – 5,000 – 4,851 10,000 Recros Medica, Inc. Recros Media – 51,006 – 8,360 – 8,000 620,269 506,042 668,412 573,935 198 19. 8,360,000 760,000 708,000 437,000 1 147,387,000 2,613,000 135,905,000 90,866,000 20. 63,830 6,831 – 97,437 * 25,238 26,664 89,068 130,932 * 199 2022 21. 134,479 129,310 80,728 49,123 167,746 134,466 113,296 45,006 496,249 357,905 11,010 3,140 485,239 354,765 22. 6,749 4,702 420,390 397,237 (38,864) (26,733) 388,275 375,206 1,960,000 2,179,000 200 22. 380,116 370,085 8,159 5,010 – 111 388,275 375,206 26,733 33,409 14,795 (2,302) (319) (3,699) (2,920) – 575 (675) 38,864 26,733 46 201 2022 23. 58,636 55,656 34,054 – 13,323 14,490 2,000 7,000 (3,162) (2,309) 104,851 74,837 2,309 3,193 721 (880) 132 (4) 3,162 2,309 46 202 24. – 6,376 Recros Medica 25. 9,159 – 203 2022 26. 2,544,592 2,901,402 (1,982,518) (1,616,895) 562,074 1,284,507 2,456 614 421 – 559,197 1,283,893 85% 91% 204 27. 54,533 46,264 36,752 38,726 15,966 1,062 1,815 6,476 54,533 46,264 90 30 90 205 2022 28. 103,334 78,698 50,864 60,907 31,575 28,923 20,680 22,447 3,711 – 31,805 40,450 94,465 79,277 32,648 46,509 27,428 16,521 – 23,597 1,200 – 397,710 397,329 4,500 8,110 Bioxis EBITA Bioxis 500,000 3,711,000 4,500,000 (a) 32,648 46,509 206 29. (%) (%) 14(b) 4.24-5.80 21,359 4.24-5.80 17,107 (a) 3.51 5,314 2.36-4.35 25,184 (c) 2.25 1,486 – – – (b) – 219 – 130 (d) 2.85 6,000 – – – 34,378 42,421 14(b) 4.24-5.80 – 39,900 4.24-5.80 – 29,608 (d) 2.85 35,745 – – – (c) 0.73 – 5,354 0.73 – 4,914 (b) – 97 – 282 (c) 2.25 – 2,784 2.25 – 4,689 83,880 39,493 118,258 81,914 207 2022 29. 11,314 25,184 39,270 2,056 1,829 2,858 52,413 30,098 23,064 17,237 18,957 11,692 19,061 17,094 4,763 5,793 65,845 51,816 118,258 81,914 (a) 3.51% 65,000,000 750,000 3,575,520 (b) ODC Industries (c) Bioxis (d) 2.85% 208 30. 6,142 133,634 8,743 9,391 157,910 38 – 25,748 – – 25,748 39 – (1,437) – – (1,437) 393 (21,982) – – (21,589) – – – 1,888 1,888 (130) 442 676 – 988 6,405 136,405 9,419 11,279 163,508 4,213 89,111 8,958 – 102,282 – 62,627 – – 62,627 2,120 (16,064) – – (13,944) – – – 9,391 9,391 (191) (2,040) (215) – (2,446) 6,142 133,634 8,743 9,391 157,910 209 2022 30. 325 – 10,214 10,288 1,740 9,180 17,609 49,356 38 – – 2,069 – – – – 2,069 (172) – (2,254) 890 (915) 1,165 1,419 133 – 6,753 – – – – – 6,753 – – 9 (13) – – 1,016 1,012 153 6,753 10,038 11,165 825 10,345 20,044 59,323 171 918 7,245 7,154 532 6,869 3,297 26,186 – – – 5,139 – 2,264 15,814 23,217 154 – 2,970 (1,991) 1,208 47 (1,305) 1,083 – (918) – – – – – (918) – – (1) (14) – – (197) (212) 325 – 10,214 10,288 1,740 9,180 17,609 49,356 210 30. 193,281,000 127,497,000 7,146,000 6,653,000 Contamac Contamac 103,728,000 68,788,000 31. 9,402 3,544 3,750 9,600 (7,652) (3,742) 5,500 9,402 211 2022 32. 585 1,180 1,765 208 – 208 – 34 34 – (1,214) (1,214) 793 – 793 – – – 38 160 1,968 2,128 425 – 425 – (67) (67) – (721) (721) 585 1,180 1,765 EndyMed Bioxis 1,180,000 33. 220,560 186,118 220,560,000 186,118,000 212 34. 174,130,100 175,822,100 1.00 174,130 175,822 177,206,600 177,207 H 1 (1,384,500) (1,385) 175,822,100 175,822 H 2 (1,692,100) (1,692) 174,130,000 174,130 1 800,000 H 0.4529% 53,702,000 44,908,000 1,384,500 H 584,500 H 2 4,551,100 H 2.5885% 174,546,000 147,672,000 1,692,100 H 2,859,000 H 84,393,000 74,042,000 2,859,000 H 213 2022 35. (a) A A A 206 204 1,450,000 1,440,000 350,000 360,000 1,800,000 204 1,440,000 95.00 0.70 95.00 94.30 93 360,000 94.30 214 35. (a) A 12 50% 24 24 50% 36 215 2022 35. (a) A – 94.30 1,800 1,800 * 720 94.30 720 94.30 180 94.30 180 94.30 1,800 * 95.00 94.30 216 35. (a) A 39,974,000 20,982,000 20.33 26.96 13.36 19.55 (%) 0.64% 0.64% (%) 42.13%/43.59% 42.08%/43.77% (%) 15.30%/18.36% 20.35%/18.38% (%) 2.18%/2.30% 2.29%/2.46% 1.5/2.5 1.5/2.5 95.49 82.70 217 2022 35. (a) A 1,800,000 1,800,000 1,800,000 167,940,000 1,800,000 A 1.31% (b) 25 8,965,000 7.09% 1 2.34% 2.31% 2.34% 2.41% 13,865,000 2.55 9,420,000 218 36. 904,838,000 37. 25% 45% 40% 40% 40% 40% Contamac 21% 21% – 40% 45% 45% 37% 36% 49% – 49% – 219 2022 37. 9,843 10,918 98,894 107,962 4,234 8,922 Contamac 82,747 74,701 – 27,137 14,102 18,656 115,802 98,645 56,235 – (3,414) (3,002) 2,932 5,162 (4,688) (5,284) Contamac 9,288 8,161 656 470 (4,553) (1,799) 1,505 (8,543) 2,105 – 220 38. 51% 70,000,000 35,000,000 35,000,000 13 1,258 15 102,050 14 2,470 30 2,069 4,107 14,594 12,224 32,064 (5,670) (19,343) (5,000) (2,479) (2,126) 30 (25,748) 110,470 (54,130) 56,340 16 13,660 70,000 35,000 35,000 14,594,000 12,224,000 221 2022 38. 35,000 (32,064) 2,936 130,011,000 4,295,000 39. 60% 41,600,000 34,379 27,128 95 100 3,987 4,022 – 38 24,014 31,990 4,265 2,367 9,469 7,650 1,032 1,268 (3,829) (2,403) (2,492) (2,834) (1,437) (1,483) (27,793) (27,137) 41,690 40,706 (90) 41,600 41,600 222 39. 41,600 (24,014) 17,586 40. (a) 35,199 46,715 17,027 (21,788) – 31,983 – 2,315 5,000 2,126 – (847) (227) 755 56,999 61,259 223 2022 40. (a) 79,424 28,657 (56,676) (23,962) – 22,582 – 1,578 13,307 18,354 (856) (494) 35,199 46,715 (b) 4,562 4,358 21,788 23,962 26,350 28,320 224 41. 589,308 470,565 42. (a) 3,790 6,124 Lifeline 3,152 2,025 (i) 3,790,000 6,124,000 (ii) Lifeline 371,000 3,152,000 2,025,000 225 2022 42. (b) 329.77 350,000 350,000 350,000 350,000 (c) 11,077 8,790 573 509 11,650 9,299 8 14A 226 43. – – 668,412 668,412 381,526 6,749 – 388,275 12,161 – – 12,161 2,877 – – 2,877 2,541,715 – – 2,541,715 2,938,279 6,749 668,412 3,613,440 54,533 – 54,533 88,972 4,500 93,472 – 220,560 220,560 118,258 – 118,258 261,763 225,060 486,823 227 2022 43. – – – 573,935 573,935 370,504 – 4,702 – 375,206 – 6,376 – – 6,376 19,181 – – – 19,181 614 – – – 614 2,900,788 – – – 2,900,788 3,291,087 6,376 4,702 573,935 3,876,100 46,264 – 46,264 106,753 8,110 114,863 – 186,118 186,118 81,914 – 81,914 234,931 194,228 429,159 228 44. 43,980 9,885 41,874 9,932 4,500 8,110 4,500 8,110 229 2022 44. – 41,874 – 41,874 – 9,932 – 9,932 230 44. – 6,749 – 6,749 48,143 268,156 352,113 668,412 48,143 274,905 352,113 675,161 – – 6,375 6,375 – 4,702 – 4,702 67,893 290,329 215,713 573,935 67,893 295,031 222,088 585,012 231 2022 44. – – 220,560 220,560 – – 4,500 4,500 – – 225,060 225,060 – – 186,118 186,118 – – 8,110 8,110 – – 194,228 194,228 232 44. 220,560,000 186,118,000 45. 5,668,000 9,123,000 233 2022 46. 82% 88% 78% 88% 5.75% 4.33% 16.68% 14.26% 234 46. – 381,526 381,526 10,161 – 10,161 10,161 381,526 391,687 – 370,504 370,504 12,181 – 12,181 12,181 370,504 382,685 235 2022 46. 1 1-2 2-3 3 4% 59% 100% 100% 390,959 19,913 2,793 6,725 17,592 11,754 2,793 6,725 1 1-2 2-3 3 4% 43% 95% 100% 380,268 8,730 2,406 5,833 14,884 3,720 2,296 5,833 236 46. 1 1-2 2-3 3 6% 9% 50% 100% 6,028 4,082 1,539 1,674 340 382 766 1,674 1 1-2 2-3 3 1% 20% 50% 100% 10,755 1,685 294 1,756 69 337 147 1,756 237 2022 46. 3 3-12 1-5 5 47,987 6,546 – – – 54,533 84,700 3,711 – 4,500 – 92,911 – 6,980 28,646 30,379 5,215 71,220 – – – 272,700 – 272,700 – 6,068 – 46,181 – 52,249 132,687 23,305 28,646 353,760 5,215 543,613 3 3-12 1-5 5 36,703 9,561 – – – 46,264 106,753 – – 8,110 – 114,863 – 24,740 3,409 11,008 – 39,157 – – – 272,700 – 272,700 – 4,576 12,531 25,558 6,681 49,346 143,456 38,877 15,940 317,376 6,681 522,330 238 46. 511,275 487,272 478,741 402,798 990,016 890,070 6,892,399 6,950,356 14.4% 12.8% 239 2022 47. 20% 2.4% 8% 4% 5.6% 140,000,000 H 84,224,000 2,859,000 H 2,859,000 H 240 48. 635,710 491,094 132,181 129,772 217 649 1,586,955 1,580,138 – 47,964 371,110 209,450 6,939 5,641 55,355 1,333 2,788,467 2,466,041 1,671,881 596,802 52,492 51,827 74,759 66,445 (168,584) 19,106 130,000 50,000 9,159 – 1,444 216 975,125 1,787,778 2,746,276 2,572,174 1,101,413 519,038 5,103 4,321 74,745 145,518 12,694 4,089 1,193,955 672,966 1,552,321 1,899,208 4,340,788 4,365,249 43,662 647 11,308 9,151 2,100 4,700 57,070 14,498 4,283,718 4,350,751 174,130 175,822 (74,042) – 4,183,630 4,174,929 4,283,718 4,350,751 241 2022 48. 3,248,866 (5,201) 88,923 747,725 4,080,313 – – – 197,256 197,256 – 57,057 – – 57,057 – 57,057 – 197,256 254,313 H (71,786) – – – (71,786) – – – (87,911) (87,911) 3,177,080 51,856 88,923 857,070 4,174,929 – – – 168,899 168,899 – 12,823 – – 12,823 – 12,823 – 168,899 181,722 H (71,938) – – – (71,938) – – – (121,891) (121,891) – (760) – 760 – 20,808 – – – 20,808 3,125,950 63,919 88,923 904,838 4,183,630 49. 242 A 1.00 A A 17.8 A A A H A 6826 688366 Contamac Contamac Holdings Limited Contamac Holdings Contamac Holdings limited 79% 1,440,000 80% A 95.00 A 94.30 243 2022 74.7993% 60% 55% H 1.00 H H A A H A 244 63.64% 51% 80% 360,000 20% A 70% 571 245 2022 A H A H % 246 EGF OK